An agonist at the 5-hydroxytryptamine 2B (5-HT2C) receptor.
ChEBI ID: 142185
| Member | Definition | Class |
|---|---|---|
| 5-methoxytryptamine | A member of the class of tryptamines that is the methyl ether derivative of serotonin. | 5-methoxytryptamine |
| ro 60-0175 | A 1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine that has S configuration. A selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. | (2S)-1-(6-chloro-5-fluoroindol-1-yl)-propan-2-amine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 230 (39.45) | 18.7374 |
| 1990's | 163 (27.96) | 18.2507 |
| 2000's | 112 (19.21) | 29.6817 |
| 2010's | 59 (10.12) | 24.3611 |
| 2020's | 19 (3.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 7 (1.01%) | 5.53% |
| Reviews | 28 (4.05%) | 6.00% |
| Case Studies | 9 (1.30%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 648 (93.64%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0107 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 0.3162 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 5 | 5 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0035 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.2015 | 3 | 4 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0752 | 6 | 6 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.5571 | 7 | 7 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0051 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.5571 | 7 | 7 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0154 | 5 | 5 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.5500 | 8 | 8 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.1362 | 2 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0690 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.0035 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| Cholecystokinin receptor type A | Homo sapiens (human) | Ki | 0.3020 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0051 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0269 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gastrin/cholecystokinin type B receptor | Homo sapiens (human) | Ki | 0.3020 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Homo sapiens (human) | IC50 | 12.0000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 0.1425 | 5 | 5 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 0.0031 | 4 | 4 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 0.0230 | 4 | 4 |
| Transporter | Rattus norvegicus (Norway rat) | EC50 | 0.0005 | 1 | 1 |