Page last updated: 2024-09-27

Peroxisomal Disorders

A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Synonyms(1)

Synonym
Peroxisomal Disorders

Research Excerpts

Overview

ExcerptReference
"Peroxisomal disorders are a newly described group of inherited neurological diseases."( Ghosh, B; Kremser, K; Pai, S; Singh, AK; Singh, I, 1996)
"Peroxisomal disorders are lethal inherited diseases caused by either defects in peroxisome assembly or dysfunction of single or multiple enzymatic function(s)."( Barbosa, E; Khan, M; Pahan, K; Sheikh, FG; Singh, I, 1998)
"Peroxisomal disorders are a group of inherited diseases in man in which either peroxisome biogenesis or one or more peroxisomal functions are impaired."( Wanders, RJ; Waterham, HR, 2006)
"Peroxisomal disorders are subdivided into peroxisome biogenesis disorders (PBDs) and single peroxisomal enzyme deficiency."( Abdel Aziz, H; Abdel Maksoud, SA; Badr El-Deen, R; El-Bassyouni, HT; Salem, FA; Thomas, MM, 2012)
"Peroxisomal disorders are a heterogeneous group of rare genetic diseases."( Englbrecht, JS; Maas, M, 2017)
"Peroxisomal disorders are a heterogeneous group of genetic disorders caused by impaired peroxisomal biogenesis or by defects in single peroxisomal proteins."( De Biase, I; Pasquali, M, 2022)
"Inherited peroxisomal disorders are associated with a wide spectrum of clinical outcomes and are broadly divided into two classes, those impacting peroxisome biogenesis (PBD) and those impacting specific peroxisomal factors."( Bhadane, P; Dahal, R; Jangam, S; Lesko, B; McPheron, M; Miller, MJ; Wangler, MF; Wilson, TE, 2023)

Research

Studies (173)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's58 (33.53)12.5806
2000's65 (37.57)18.1394
2010's42 (24.28)28.8240
2020's8 (4.62)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formic acid0low10
carnitine0low70
choline0low40
creatine0low20
lactic acid0low20
dihydroxyacetone phosphate0low20
glycine0low10
glyoxylic acid0low30
pipecolic acid0low140
inositol0low20
palmitic acid0low10
propylene glycol0low10
sarcosine0low10
urea0low10
1-anilino-8-naphthalenesulfonate0low10
amitrole0low10
busulfan0low10
carbonyl cyanide m-chlorophenyl hydrazone0low10
clofibrate0low10
ether0low20
gentamicin0low10
batyl alcohol0low10
indomethacin0low10
nipecotic acid0low10
4-phenylbutyric acid0low10
propofol0low10
propyl gallate0low10
sevoflurane0low10
carbachol0low10
dehydroepiandrosterone0low30
aspartic acid0low40
glutamine0low10
lysine0low10
tyrosine0low10
methionine0low10
phenylalanine0low10
histidine0low10
valine0low10
tryptophan0low10
isoleucine0low10
arginine0low30
trifluoroacetic acid0low10
deanol0low10
diethylhexyl phthalate0low10
pirinitramide0low10
lithocholic acid0low10
glycocholic acid0low10
kainic acid0low10
malondialdehyde0low20
lignoceric acid0low40
acetylcysteine0low10
dicarbethoxydihydrocollidine0low10
dehydroepiandrosterone sulfate0low10
d-alpha tocopherol0low20
tricosanoic acid0low10
vidarabine0low10
deuterium0medium31
phytanic acid0medium361
tetradecanoylphorbol acetate0low10
iodine0low10
phosphotyrosine0low10
phenyl acetate0low10
cetylpyridinium chloride anhydrous0low10
ursodeoxycholic acid0low10
pyrene0low10
n-methyl-n-(trimethylsilyl)trifluoroacetamide0low10
glutamic acid0low10
s-adenosylmethionine0low70
ng-nitroarginine methyl ester0low10
lovastatin0low20
remifentanil0low10
n-acetylaspartic acid0low30
n-methyl-bis(trifluoroacetamide)0low10
sulfolithocholylglycine0low10
4-phenylbutylamine0low10
coenzyme a0low20
7-ketocholesterol0low10
acetoacetyl coa0low10
gamma-tocopherol0low10
2-hydroxyisovaleric acid0low10
cerebronic acid0low10
3,7,11,15-tetramethyl-1-hexadecanol0low10
1-hexadecyl-2-acetyl-glycero-3-phosphocholine0low10
valerates0low10
12-(1-pyrene)dodecanoic acid0low20
2-methylhexadecanoic acid0low10
3,7,12-trihydroxycholestan-26-oic acid0low30
antibiotic g 4180low10
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone0low10
pristanic acid0medium312
glycerophosphoinositol 4,5-bisphosphate0low10
methotrexate0low10
15-hydroxyeicosatrienoic acid0low10
phytol0low10
naproxen0low10
3,7,12-trihydroxycoprostane0low10
palmitoyl dihydroxyacetone phosphate0low10
lanosterol0low20
mevalonic acid0low10
3,7-dihydroxycholestan-26-oic acid0low20
rocuronium0low10
acetyl coenzyme a0low10
arachidonic acid0low20
oleic acid0low20
farnesyl pyrophosphate0low30
squalene0low10
flavin-adenine dinucleotide0low10
palmitoyl coenzyme a0low10
fludarabine0low10
sesquiterpenes0low30
lithium0low10
3,7,12,24-tetrahydroxycholestanoic acid0low10
dihydroxycoprostane0low10
psychosine0low10
alpha-linolenic acid0low10
amphotericin b0low10
coenzyme q100low20
morphine0medium11
lysophosphatidylcholines0low30
12-hydroxy-5,8,10,14-eicosatetraenoic acid0low10
cysteine0low10
triolein0low40
docosapentaenoic acid0low20
4,7,10,13,16,19-docosahexaenoic acid ethyl ester0low20
phosphocreatine0low10
etomoxir0low10
alpha-synuclein0low20
oxadiazoles0low10
ptc 1240low10
cytochrome c-t0low10
phosphatidylcholines0low30
ubiquinone0low20
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene0low10
ganglioside, gd1a0low10
glycolipids0low30
piperidines0low10
eliglustat tartrate0low10
ascorbic acid0low10
g(m3) ganglioside0low10
deoxyguanosine0low10
ganciclovir0low10
8-hydroxy-2'-deoxyguanosine0low10
eye0low20

Protein Targets (943)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A8008
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase3003
thioredoxin reductase140014
USP1 protein, partial120012
TDP1 protein220022
vitamin D3 receptor isoform VDRA130013
importin subunit beta-1 isoform 17007
flap endonuclease 19009
serine/threonine-protein kinase PLK15005
snurportin-17007
peptidyl-prolyl cis-trans isomerase NIMA-interacting 16006
GTP-binding nuclear protein Ran isoform 13003
DNA polymerase eta isoform 13003
DNA polymerase iota isoform a (long)140014
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
geminin260026
DNA polymerase kappa isoform 1110011
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0022
Fatty acid-binding protein, intestinal0213
Fatty acid-binding protein, adipocyte0639
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20123
Choline O-acetyltransferase0202
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G5005
Fatty acid-binding protein 50426
Fatty acid-binding protein 50022
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE170017
Chain A, Cruzipain8008
regulator of G-protein signaling 46006
Platelet-activating factor receptor1203
Inositol monophosphatase 14004
Solute carrier family 22 member 200404
Solute carrier family 22 member 60404
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Membrane primary amine oxidase0001
Cationic trypsin0101
Amine oxidase [flavin-containing] A0101
Membrane primary amine oxidase0001
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
mitogen-activated protein kinase 14004
survival motor neuron protein isoform d100010
Histone deacetylase 30303
Histone deacetylase 40303
Histone deacetylase 10404
Histone deacetylase 70303
Histone deacetylase 20404
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80303
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60404
Histone deacetylase 90303
Histone deacetylase 50303
Rap guanine nucleotide exchange factor 35005
NPC1-like intracellular cholesterol transporter 10022
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Chain A, 2-ENOYL-COA HYDRATASE0101
Chain B, 2-ENOYL-COA HYDRATASE0101
N-alpha-acetyltransferase 500022
Chain A, 2-oxoglutarate Oxygenase100010
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
acetylcholinesterase110011
dopamine D1 receptor2002
15-lipoxygenase, partial9009
pregnane X receptor4004
phosphopantetheinyl transferase170017
RAR-related orphan receptor gamma190019
NFKB1 protein, partial3003
Microtubule-associated protein tau150015
Thrombopoietin1001
AR protein280028
glucocorticoid receptor [Homo sapiens]210021
retinoic acid nuclear receptor alpha variant 1270027
retinoid X nuclear receptor alpha170017
farnesoid X nuclear receptor150015
estrogen nuclear receptor alpha370037
vitamin D (1,25- dihydroxyvitamin D3) receptor160016
arylsulfatase A7007
euchromatic histone-lysine N-methyltransferase 2230023
Bloom syndrome protein isoform 1150015
D(1A) dopamine receptor3003
thyroid hormone receptor beta isoform a6006
thyroid hormone receptor beta isoform 2230023
heat shock protein beta-1140014
peripheral myelin protein 22100010
muscarinic acetylcholine receptor M15005
Solute carrier family 22 member 60303
Ataxin-25005
ATP-dependent phosphofructokinase120012
interleukin 87007
thyroid stimulating hormone receptor130013
estrogen receptor 2 (ER beta)150015
progesterone receptor120012
estrogen-related nuclear receptor alpha250025
IDH17007
transcriptional regulator ERG isoform 33003
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 1230023
lamin isoform A-delta10210021
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 4012014
Polyphenol oxidase 20203
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump014015
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p53230023
Glutamate receptor 284214
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0303
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0022
TAR DNA-binding protein 437007
Canalicular multispecific organic anion transporter 10808
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE110011
Chain A, Beta-lactamase110011
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Luciferase9009
WRN2002
hypoxia-inducible factor 1 alpha subunit8008
SMAD family member 2120012
GLS protein100010
SMAD family member 3120012
GLI family zinc finger 3190019
thioredoxin glutathione reductase5005
aldehyde dehydrogenase 1 family, member A1130013
pregnane X nuclear receptor130013
peroxisome proliferator-activated receptor delta160016
peroxisome proliferator activated receptor gamma160016
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 6100010
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a9009
v-jun sarcoma virus 17 oncogene homolog (avian)110011
Caspase-73003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
phospholipase A2 precursor0101
caspase-33003
cysteine protease ATG4B isoform a0101
lethal(3)malignant brain tumor-like protein 1 isoform I3003
cytochrome P450 3A4 isoform 1130013
histone acetyltransferase KAT2A isoform 19009
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Gamma-aminobutyric acid receptor subunit pi132116
Free fatty acid receptor 10011
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Prostaglandin G/H synthase 1 0507
Nuclear receptor subfamily 1 group I member 20011
Trypsin0303
Coagulation factor VII0303
Aromatase0404
Tissue factor0303
Gamma-aminobutyric acid receptor subunit beta-1132116
Gamma-aminobutyric acid receptor subunit delta132116
Gamma-aminobutyric acid receptor subunit gamma-2132116
Gamma-aminobutyric acid receptor subunit alpha-5132116
Gamma-aminobutyric acid receptor subunit alpha-3132116
Prostaglandin G/H synthase 10404
Gamma-aminobutyric acid receptor subunit gamma-1132116
Gamma-aminobutyric acid receptor subunit alpha-2132116
Gamma-aminobutyric acid receptor subunit alpha-4132116
Gamma-aminobutyric acid receptor subunit gamma-3132116
Gamma-aminobutyric acid receptor subunit alpha-6132116
Peroxisome proliferator-activated receptor gamma0044
Histamine H2 receptor6006
Gamma-aminobutyric acid receptor subunit alpha-1132116
Gamma-aminobutyric acid receptor subunit beta-3132116
Gamma-aminobutyric acid receptor subunit beta-2132116
Prostaglandin G/H synthase 20607
Free fatty acid receptor 40011
GABA theta subunit132116
Gamma-aminobutyric acid receptor subunit epsilon132116
Integrase 0101
tumor necrosis factor1001
Cytochrome P450 1A20202
Cytochrome P450 3A40315
Cytochrome P450 2D60101
Cytochrome P450 2C9 0202
Cytochrome P450 2C190101
Nuclear receptor ROR-gamma8008
Potassium voltage-gated channel subfamily H member 20303
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20102
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0022
Chain A, SERUM ALBUMIN0022
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
cellular tumor antigen p53 isoform a3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
nuclear receptor ROR-gamma isoform 1100010
caspase-1 isoform alpha precursor2002
Fatty-acid amide hydrolase 10303
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Prostaglandin G/H synthase 20427
Nuclear receptor subfamily 4 group A member 20022
10 kDa heat shock protein, mitochondrial0202
Calmodulin 0001
Disintegrin and metalloproteinase domain-containing protein 174004
Solute carrier organic anion transporter family member 2A10001
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0203
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Solute carrier organic anion transporter family member 1B30507
Cytosolic phospholipase A2 gamma0202
Transient receptor potential cation channel subfamily V member 20303
Solute carrier organic anion transporter family member 1B10607
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
alpha-galactosidase2002
cytochrome P450 2C19 precursor2002
chromobox protein homolog 1150015
lethal factor (plasmid)9009
Nitric oxide synthase, endothelial0103
Nitric oxide synthase, brain0102
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0203
Nitric oxide synthase, inducible0114
Cationic amino acid transporter 30202
Chain A, Hyaluronidase, phage associated0101
cytochrome P450 family 3 subfamily A polypeptide 4160016
nuclear factor erythroid 2-related factor 2 isoform 26006
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein6006
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain8008
Metabotropic glutamate receptor 60135
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 102010
Carbonic anhydrase 202111
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 07314
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 07314
Glutamate receptor ionotropic, NMDA 2B07314
Glutamate receptor ionotropic, NMDA 2C07314
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0007
Glutamate receptor ionotropic, NMDA 2D07314
Glutamate receptor ionotropic, NMDA 3B07314
Carbonic anhydrase 40002
Glutamate receptor ionotropic, NMDA 3A07314
67.9K protein8008
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
apical membrane antigen 1, AMA11001
EWS/FLI fusion protein110011
aryl hydrocarbon receptor7007
Matrix metalloproteinase-90101
GALC protein3003
thyroid stimulating hormone receptor100010
thyrotropin-releasing hormone receptor4004
Neuronal acetylcholine receptor subunit alpha-30202
Muscarinic acetylcholine receptor M20225
Muscarinic acetylcholine receptor M40225
Muscarinic acetylcholine receptor M10327
Muscarinic acetylcholine receptor M30326
Muscarinic acetylcholine receptor M40315
Muscarinic acetylcholine receptor M50315
Muscarinic acetylcholine receptor M50225
Neuronal acetylcholine receptor subunit alpha-40303
Muscarinic acetylcholine receptor M20315
Muscarinic acetylcholine receptor M10225
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20303
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30225
Neuronal acetylcholine receptor subunit alpha-50202
Delta-type opioid receptor0103
Neuronal acetylcholine receptor subunit alpha-60202
Neuronal acetylcholine receptor subunit alpha-90202
Neuronal acetylcholine receptor subunit alpha-70202
Sigma non-opioid intracellular receptor 10112
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100202
Chain A, PAPAIN1001
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
nuclear receptor subfamily 1, group I, member 3130013
Histone H2A.x7007
histone deacetylase 9 isoform 33003
ATPase family AAA domain-containing protein 54004
CDGSH iron-sulfur domain-containing protein 10606
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
caspase 7, apoptosis-related cysteine protease5005
caspase-35005
Caspase-20011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0103
Solute carrier family 22 member 20101
Acetylcholinesterase0101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0102
Solute carrier family 22 member 10102
High affinity choline transporter 10101
Solute carrier family 22 member 20102
Fumarate hydratase3003
polyprotein3003
peripheral myelin protein 22 isoform 14004
potassium voltage-gated channel subfamily H member 2 isoform d6006
M-phase phosphoprotein 84004
5-hydroxytryptamine receptor 40213
Fatty acid-binding protein, liver0415
Peroxisome proliferator-activated receptor alpha0011
Peroxisome proliferator-activated receptor gamma0011
Peroxisome proliferator-activated receptor alpha3047
Histone acetyltransferase p3000101
Histone acetyltransferase KAT2B0101
Histone acetyltransferase KAT50101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10404
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
glp-1 receptor, partial2002
cytochrome P450 2D65005
Sex hormone-binding globulin0011
Beta-glucuronidase0101
Corticosteroid-binding globulin0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
Alpha-synuclein3104
G-protein coupled bile acid receptor 10055
Glucose-6-phosphate 1-dehydrogenase 0101
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50002
Steryl-sulfatase0001
Multidrug resistance-associated protein 1 0204
Solute carrier organic anion transporter family member 1A10002
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30103
ATP-binding cassette sub-family C member 110002
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Thymidine kinase, cytosolic0103
Deoxycytidine kinase0001
AAA family ATPase 0001
Sterol O-acyltransferase 10101
Oligo-1,6-glucosidase IMA10101
Rap guanine nucleotide exchange factor 44004
G7007
bromodomain adjacent to zinc finger domain 2B3003
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 7007
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Chain A, ALDOLASE0011
Geranylgeranyl pyrophosphate synthase0001
Protein farnesyltransferase subunit beta0001
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0001
Squalene synthase0001
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0012
Protein farnesyltransferase subunit beta0012
Squalene synthase0102
Geranylgeranyl pyrophosphate synthase0001
Smad34004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
corticotropin-releasing hormone receptor 20112
corticotropin releasing factor-binding protein0112
glycogen synthase kinase-3 beta isoform 10022
5'-nucleotidase0101
Adenosine receptor A30101
Adenosine deaminase 0002
Thymidine kinase 0101
endonuclease IV2002
ClpP2002
POU domain, class 2, transcription factor 20001
Transitional endoplasmic reticulum ATPase0101
Solute carrier family 22 member 60204
cytochrome P450 2C9 precursor2002
muscleblind-like protein 1 isoform 12002
Cytochrome P450 2C80101
Cannabinoid receptor 20011
Guanylate cyclase soluble subunit alpha-10011
Guanylate cyclase soluble subunit beta-10011
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Integrin beta-32013
Integrin alpha-IIb2013
ATP-citrate synthase 0101
Glutamate receptor 10426
Glutamate receptor 30426
Glutamate receptor 40426
Glutamate receptor ionotropic, kainate 10426
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10325
Metabotropic glutamate receptor 50124
Glutamate receptor ionotropic, kainate 20437
Glutamate receptor 10325
Glutamate receptor 20325
Glutamate receptor 30123
Glutamate receptor ionotropic, kainate 30404
Metabotropic glutamate receptor 80011
Glutamate receptor 40314
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate receptor ionotropic, kainate 40404
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20325
Glutamate receptor ionotropic, kainate 30303
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50303
Glutamate receptor ionotropic, kainate 50404
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
histone-lysine N-methyltransferase 2A isoform 2 precursor4004
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent glycine transporter 10202
Large neutral amino acids transporter small subunit 10809
Serine racemase0101
Olfactory receptor 51E20033
Sodium- and chloride-dependent glycine transporter 20101
Sodium/bile acid cotransporter0001
Multidrug resistance associated protein0103
Bile salt export pump0001
4-hydroxy-tetrahydrodipicolinate synthase0101
Chain A, HISTIDINE-BINDING PROTEIN0011
ATAD5 protein, partial3003
Carbonic anhydrase 120004
Plasma kallikrein0004
Carbonic anhydrase 30004
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40105
Carbonic anhydrase 60004
Adenosine receptor A10205
Adenosine receptor A2a0205
Carbonic anhydrase 5A, mitochondrial0004
Carbonic anhydrase0105
Carbonic anhydrase 70004
Carbonic anhydrase0004
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90004
Carbonic anhydrase 0004
Carbonic anhydrase0004
Carbonic anhydrase0004
Carbonic anhydrase 0004
Carbonic anhydrase 130002
Carbonic anhydrase 150105
Carbonic anhydrase 130003
Carbonic anhydrase 140004
Carbonic anhydrase 5B, mitochondrial0004
Chain A, membrane-associated prostaglandin E synthase-20101
glucocerebrosidase1001
Parkin2002
cytochrome P450 2D6 isoform 11001
serine/threonine-protein kinase mTOR isoform 11001
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Albumin0112
Prostaglandin G/H synthase 10304
Procathepsin L0101
ATP-dependent translocase ABCB10303
Interleukin-80101
Androgen receptor0011
Polyunsaturated fatty acid 5-lipoxygenase0205
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40202
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10202
Thromboxane-A synthase 0101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10102
Substance-P receptor0202
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20303
Sodium- and chloride-dependent GABA transporter 30202
Prostaglandin E2 receptor EP4 subtype0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 2 0203
Prostaglandin E2 receptor EP1 subtype0101
Aldo-keto reductase family 1 member C30303
Sodium- and chloride-dependent betaine transporter0202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0202
Prostaglandin D2 receptor 0202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10202
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0202
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0203
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80102
Multidrug and toxin extrusion protein 10101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Prostaglandin D2 receptor 20112
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
Amyloid-beta precursor protein0202
Sodium/myo-inositol cotransporter 20101
Chain A, Glutamate receptor 20011
Chain A, Glutamate receptor 20011
Chain C, Glutamate receptor 20011
Glutamate receptor ionotropic, kainate 40101
Alpha-crystallin B chain0011
Lanosterol 14-alpha demethylase0001
14-alpha sterol demethylase 0001
Chain A, Breast cancer type 1 susceptibility protein1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10101
Ubiquitin carboxyl-terminal hydrolase 20202
Vitamin D3 receptor0235
Tyrosine-protein phosphatase non-receptor type 20101
Tyrosine-protein phosphatase non-receptor type 10303
Ephrin type-A receptor 20101
Caspase-72002
Ephrin type-A receptor 20101
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0101
Bile acid receptor0123
large T antigen0101
Chain A, Antigen Cd11a (p180)0101
PINK11001
isocitrate dehydrogenase 1, partial1001
nuclear receptor subfamily 1, group I, member 23003
bcl-2-related protein A10101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Integrin beta-20101
Intercellular adhesion molecule 10101
Aldo-keto reductase family 1 member B10404
Neutrophil elastase0202
Insulin receptor 0101
Androgen receptor0202
Integrin alpha-L0112
Substance-K receptor0202
Sodium-dependent noradrenaline transporter 0404
Adenosine receptor A10202
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Sodium-dependent dopamine transporter 0202
Acyl-CoA:cholesterol acyltransferase 0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0506
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0112
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Delta-type opioid receptor0315
Mu-type opioid receptor0418
Kappa-type opioid receptor0315
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Proton-coupled folate transporter0101
Protein-arginine deiminase type-40101
tumor susceptibility gene 101 protein1001
Serine racemase0101
Opioid receptor, delta 1b 0101
Acetylcholinesterase0202
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
Alpha-2A adrenergic receptor0011
Translocator protein0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0214
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
Hormone-sensitive lipase0101
Caspase-30101
Caspase-40101
Cytochrome P450 2J20101
Caspase-50101
Caspase-90101
Nitric oxide synthase, endothelial0101
Collagenase 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Sodium- and chloride-dependent GABA transporter 20101
Chain A, Adipocyte Lipid-binding Protein0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, BCL-2-RELATED PROTEIN A10011
putative potassium channel subunit0011
serine-protein kinase ATM isoform a1001
bcl-2-like protein 11 isoform 10011
Sterol O-acyltransferase 10101
Fatty acid-binding protein, liver0112
Seed linoleate 13S-lipoxygenase-10101
DNA topoisomerase 10101
Protein kinase C alpha type0113
Sterol O-acyltransferase 10101
Peroxisome proliferator-activated receptor delta0001
Chain A, Fatty acid-binding protein, adipocyte0101
Toll-like receptor 20101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0202
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0003
Large neutral amino acids transporter small subunit 1 0101
Monocarboxylate transporter 100003
Phospholipase A-2-activating protein0202
Tyrosine-protein kinase Lck0001
Proto-oncogene tyrosine-protein kinase Src0001
Growth factor receptor-bound protein 20001
Tyrosine-protein phosphatase non-receptor type 110001
Peroxisomal sarcosine oxidase0001
Free fatty acid receptor 30011
Free fatty acid receptor 20112
Free fatty acid receptor 20011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Anthrax toxin receptor 20101
Flavin reductase (NADPH)0011
Cytochrome P450 1A10101
Polypeptide N-acetylgalactosaminyltransferase 20101
Cytochrome P450 1B10101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Met repressor 0022
Protein arginine N-methyltransferase 50011
Histone H3K27 methylase0001
Phenylethanolamine N-methyltransferase0012
S-adenosylmethionine decarboxylase proenzyme0102
Protein-L-isoaspartate(D-aspartate) O-methyltransferase0101
Catechol O-methyltransferase0001
Protein arginine N-methyltransferase 10101
Methylosome protein 500011
Squalene monooxygenase 0001
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Luciferin 4-monooxygenase0011
Beta-1 adrenergic receptor0101
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Myeloperoxidase0101
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Urease subunit alpha0101
Urease subunit beta0101
Glucocorticoid receptor0011
Ileal sodium/bile acid cotransporter0101
Sodium/bile acid cotransporter0101
M1-family alanyl aminopeptidase0101
Carbonic anhydrase0101
Chain A, Arginase 10101
Dipeptidyl peptidase 40101
Histamine H1 receptor0011
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]