Page last updated: 2024-08-05 12:13:14
purine arabinonucleoside monophosphate
A purine nucleoside monophosphate in which the sugar component is specified as arabinosyl.
ChEBI ID: 37514
Members (1)
| Member | Definition | Role |
|---|---|---|
| fludarabine phosphate | A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. | fludarabine phosphate |
Research
Studies (215)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 41 (19.07) | 18.7374 |
| 1990's | 89 (41.40) | 18.2507 |
| 2000's | 59 (27.44) | 29.6817 |
| 2010's | 21 (9.77) | 24.3611 |
| 2020's | 5 (2.33) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 46 (21.10%) | 5.53% |
| Reviews | 25 (11.47%) | 6.00% |
| Case Studies | 24 (11.01%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 123 (56.42%) | 84.16% |