Poland Anomaly

A syndrome which is characterized by symbrachydactyly and aplasia of the sternal head of pectoralis major.

Synonym
Poland Anomaly
Poland Sequence
Poland Syndrome
Poland Syndactyly

Excerpt	Reference
"Poland syndrome is a rare congenital malformation."	( Algar Algar, J; Arango Tomás, E; Baamonde Laborda, C; Salvatierra Velázquez, A, 2013)
"Poland Syndrome is a rare congenital disease associated with muscle development."	( Díaz-Crespo, J; García-Herrera, F; Vázquez-Mambrilla, Y, 2017)
"Poland syndrome is a rare congenital disease, characterized by agenesis/hypoplasia of the pectoralis major muscle, usually associated with variable thoracic anomalies that needed chest wall reconstruction under general anesthesia."	( Gui, L; Mei, W; Shen, S, 2018)
"Poland syndrome is a rare congenital anomaly characterized by unilateral aplasia of the sternoclavicular head of pectoralis major muscle with varying degree of same side upper limb anomalies."	( Asopa, RV; Loharkar, S; Malhotra, G, 2021)

Excerpt	Reference
"Poland syndrome has been sporadically associated with hematological conditions, primarily acute leukemias."	( Aslan, D; Balci, S, 2004)
"Poland syndrome has been attributed to a process of vascular disruption, and exposure to misoprostol at 6-8 weeks of gestation has been shown to produce defects attributed to vascular disruption."	( Graziadio, C; Kiss, A; Paskulin, GA; Pinto, LL; Rosa, RF; Travi, GM; Valiatti, F; Zen, PR, 2007)

Excerpt	Reference
"The authors describe a case of Poland syndrome in a ventilator-dependent premature infant with severe chest wall deformities treated during the neonatal period with a prosthetic titanium mesh."	( Buckner, DM; Lasko, D; Sola, JE; Thompson, WR, 2008)
"Despite various neurologic symptoms of Poland syndrome (PS), parkinsonism was never reported in PS, and the response to the treatment of parkinsonism was not studied before."	( Fasano, A; Gorodetsky, C; Lang, AE; Lozano, AM; Youn, J, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	8 (16.33)	23.3326
1990's	17 (34.69)	12.5806
2000's	12 (24.49)	18.1394
2010's	8 (16.33)	28.8240
2020's	4 (8.16)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	4
bupivacaine	low	1
busulfan	low	1
halothane	low	1
midazolam	low	2
propofol	low	2
succinylcholine	low	1
levodopa	low	1
medroxyprogesterone acetate	low	1
isoprene	low	1
methylmethacrylate	low	1
ethamsylate	low	1
titanium	low	3
trolamine salicylate	low	1
sufentanil	low	1
fluorodeoxyglucose f18	low	1
elastin	low	1
inositol 3-phosphate	low	1
rocuronium	low	1
retinol	low	1
misoprostol	low	3
phenylephrine hydrochloride	low	3
silicon	low	2
caesium-137	low	1
menotropins	low	1
ascorbic acid	low	1
chondroitin sulfates	low	1
allopurinol	low	1

Protein Targets (339)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
interleukin 8	4	0	0	4
TDP1 protein	6	0	0	6
AR protein	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
estrogen receptor 2 (ER beta)	2	0	0	2
progesterone receptor	3	0	0	3
glucocorticoid receptor [Homo sapiens]	8	0	0	8
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	13	0	0	13
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
Bloom syndrome protein isoform 1	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	6	0	0	6
ras-related protein Rab-9A	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
geminin	10	0	0	10
survival motor neuron protein isoform d	2	0	0	2
lamin isoform A-delta10	8	0	0	8
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Polyphenol oxidase 2	0	3	0	5
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	6	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	7	0	0	7
Glutamate receptor 2	3	0	0	3
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	0	1	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	2	0	0	2
RAR-related orphan receptor gamma	5	0	0	5
GLI family zinc finger 3	5	0	0	5
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
chromobox protein homolog 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	3	0	0	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
15-lipoxygenase, partial	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
EWS/FLI fusion protein	2	0	0	2
retinoid X nuclear receptor alpha	5	0	0	5
pregnane X nuclear receptor	4	0	0	4
aryl hydrocarbon receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Chain A, Cruzipain	4	0	0	4
Albumin	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Luciferase	1	0	0	1
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	5	0	0	5
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
GLS protein	2	0	0	2
arylsulfatase A	1	0	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
flap endonuclease 1	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	1	0	0	1
peripheral myelin protein 22	6	0	0	6
M-phase phosphoprotein 8	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
Carbonic anhydrase 12	0	1	0	2
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	4
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Carbonic anhydrase 3	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
phosphoglycerate kinase	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
pregnane X receptor	2	0	0	2
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	2	0	0	2
SMAD family member 3	2	0	0	2
PINK1	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
nonstructural protein 1	1	0	0	1
farnesoid X nuclear receptor	2	0	0	2
G	3	0	0	3
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	2	1	6
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Estrogen receptor	0	1	1	2
Glucocorticoid receptor	0	2	1	3
Sex hormone-binding globulin	0	0	1	1
Progesterone receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit delta	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	3	2	1	6
Androgen receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	3	2	1	6
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	3	2	1	6
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H2 receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	3	2	1	6
5-hydroxytryptamine receptor 1B	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	2	1	6
Alpha-synuclein	1	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit beta-3	3	2	1	6
Guanine nucleotide-binding protein G	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	3	2	1	6
Aldo-keto reductase family 1 member C1	0	1	0	1
GABA theta subunit	3	2	1	6
Inositol hexakisphosphate kinase 1	3	0	0	3
Estrogen receptor beta	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	3	2	1	6
cytochrome P450 2C9, partial	3	0	0	3
Solute carrier family 22 member 1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Translocator protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Microtubule-associated protein tau	2	0	0	2
cytochrome P450 2D6	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
DNA polymerase beta	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
glp-1 receptor, partial	1	0	0	1
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
USP1 protein, partial	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
activating transcription factor 6	1	0	0	1
Histone H2A.x	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
heat shock protein beta-1	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (49)

Protein Targets (339)

Poland Anomaly

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (49)

Drugs Studied (33)

Protein Targets (339)