Poland Anomaly

A syndrome which is characterized by symbrachydactyly and aplasia of the sternal head of pectoralis major.

Synonyms(4)

Synonym
Poland Anomaly
Poland Sequence
Poland Syndrome
Poland Syndactyly

Research Excerpts

Overview

Excerpt	Reference
"Poland syndrome is a rare congenital malformation."	( Algar Algar, J; Arango Tomás, E; Baamonde Laborda, C; Salvatierra Velázquez, A, 2013)
"Poland Syndrome is a rare congenital disease associated with muscle development."	( Díaz-Crespo, J; García-Herrera, F; Vázquez-Mambrilla, Y, 2017)
"Poland syndrome is a rare congenital disease, characterized by agenesis/hypoplasia of the pectoralis major muscle, usually associated with variable thoracic anomalies that needed chest wall reconstruction under general anesthesia."	( Gui, L; Mei, W; Shen, S, 2018)
"Poland syndrome is a rare congenital anomaly characterized by unilateral aplasia of the sternoclavicular head of pectoralis major muscle with varying degree of same side upper limb anomalies."	( Asopa, RV; Loharkar, S; Malhotra, G, 2021)

Context

Excerpt	Reference
"Poland syndrome has been sporadically associated with hematological conditions, primarily acute leukemias."	( Aslan, D; Balci, S, 2004)
"Poland syndrome has been attributed to a process of vascular disruption, and exposure to misoprostol at 6-8 weeks of gestation has been shown to produce defects attributed to vascular disruption."	( Graziadio, C; Kiss, A; Paskulin, GA; Pinto, LL; Rosa, RF; Travi, GM; Valiatti, F; Zen, PR, 2007)

Treatment

Excerpt	Reference
"The authors describe a case of Poland syndrome in a ventilator-dependent premature infant with severe chest wall deformities treated during the neonatal period with a prosthetic titanium mesh."	( Buckner, DM; Lasko, D; Sola, JE; Thompson, WR, 2008)
"Despite various neurologic symptoms of Poland syndrome (PS), parkinsonism was never reported in PS, and the response to the treatment of parkinsonism was not studied before."	( Fasano, A; Gorodetsky, C; Lang, AE; Lozano, AM; Youn, J, 2023)

Research

Studies (49)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	8 (16.33)	23.3326
1990's	17 (34.69)	12.5806
2000's	12 (24.49)	18.1394
2010's	8 (16.33)	28.8240
2020's	4 (8.16)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	4
bupivacaine	low	1
busulfan	low	1
halothane	low	1
midazolam	low	2
propofol	low	2
succinylcholine	low	1
levodopa	low	1
medroxyprogesterone acetate	low	1
isoprene	low	1
methylmethacrylate	low	1
ethamsylate	low	1
titanium	low	3
trolamine salicylate	low	1
sufentanil	low	1
fluorodeoxyglucose f18	low	1
elastin	low	1
inositol 3-phosphate	low	1
rocuronium	low	1
retinol	low	1
misoprostol	low	3
phenylephrine hydrochloride	low	3
silicon	low	2
caesium-137	low	1
menotropins	low	1
ascorbic acid	low	1
chondroitin sulfates	low	1
allopurinol	low	1

Protein Targets (339)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
interleukin 8	4	0	0	4
TDP1 protein	6	0	0	6
AR protein	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
estrogen receptor 2 (ER beta)	2	0	0	2
progesterone receptor	3	0	0	3
glucocorticoid receptor [Homo sapiens]	8	0	0	8
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	13	0	0	13
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
Bloom syndrome protein isoform 1	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	6	0	0	6
ras-related protein Rab-9A	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
geminin	10	0	0	10
survival motor neuron protein isoform d	2	0	0	2
lamin isoform A-delta10	8	0	0	8
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Polyphenol oxidase 2	0	3	0	5
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	6	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	7	0	0	7
Glutamate receptor 2	3	0	0	3
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	0	1	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	2	0	0	2
RAR-related orphan receptor gamma	5	0	0	5
GLI family zinc finger 3	5	0	0	5
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
chromobox protein homolog 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	3	0	0	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
15-lipoxygenase, partial	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
EWS/FLI fusion protein	2	0	0	2
retinoid X nuclear receptor alpha	5	0	0	5
pregnane X nuclear receptor	4	0	0	4
aryl hydrocarbon receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Chain A, Cruzipain	4	0	0	4
Albumin	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Luciferase	1	0	0	1
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	5	0	0	5
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
GLS protein	2	0	0	2
arylsulfatase A	1	0	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
flap endonuclease 1	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	1	0	0	1
peripheral myelin protein 22	6	0	0	6
M-phase phosphoprotein 8	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
Carbonic anhydrase 12	0	1	0	2
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	4
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Carbonic anhydrase 3	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
phosphoglycerate kinase	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
pregnane X receptor	2	0	0	2
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	2	0	0	2
SMAD family member 3	2	0	0	2
PINK1	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
nonstructural protein 1	1	0	0	1
farnesoid X nuclear receptor	2	0	0	2
G	3	0	0	3
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	2	1	6
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Estrogen receptor	0	1	1	2
Glucocorticoid receptor	0	2	1	3
Sex hormone-binding globulin	0	0	1	1
Progesterone receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit delta	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	3	2	1	6
Androgen receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	3	2	1	6
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	3	2	1	6
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H2 receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	3	2	1	6
5-hydroxytryptamine receptor 1B	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	2	1	6
Alpha-synuclein	1	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit beta-3	3	2	1	6
Guanine nucleotide-binding protein G	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	3	2	1	6
Aldo-keto reductase family 1 member C1	0	1	0	1
GABA theta subunit	3	2	1	6
Inositol hexakisphosphate kinase 1	3	0	0	3
Estrogen receptor beta	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	3	2	1	6
cytochrome P450 2C9, partial	3	0	0	3
Solute carrier family 22 member 1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Translocator protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Microtubule-associated protein tau	2	0	0	2
cytochrome P450 2D6	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
DNA polymerase beta	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
glp-1 receptor, partial	1	0	0	1
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
USP1 protein, partial	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
activating transcription factor 6	1	0	0	1
Histone H2A.x	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
heat shock protein beta-1	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

chemdatabank.com

Poland Anomaly

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (49)

Drugs Studied (33)

Protein Targets (339)