null
ChEBI ID: 48278
| Member | Definition | Class |
|---|---|---|
| apomorphine | apomorphine | |
| clomipramine | A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias. | clomipramine |
| clomipramine hydrochloride | A hydrochloride resulting from the reaction of equimolar amounts of clomipramine and hydrogen chloride. One of the more sedating tricyclic antidepressants, it is used for the treatment of depression as well as obsessive-compulsive disorder and phobias. | clomipramine hydrochloride |
| roxindole | roxindole | |
| zotepine | zotepine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,869 (50.61) | 18.7374 |
| 1990's | 2,722 (23.47) | 18.2507 |
| 2000's | 1,760 (15.18) | 29.6817 |
| 2010's | 1,045 (9.01) | 24.3611 |
| 2020's | 201 (1.73) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 862 (6.97%) | 5.53% |
| Reviews | 694 (5.61%) | 6.00% |
| Case Studies | 631 (5.10%) | 4.05% |
| Observational | 13 (0.11%) | 0.25% |
| Other | 10,167 (82.21%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 0.0478 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 15.8489 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 31.5536 | 3 | 7 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 4.4223 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 29.6797 | 8 | 27 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 4.3080 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.2133 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 12.0756 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 17.1065 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 10.0789 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 18.5970 | 1 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 3.7933 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 7.3621 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 42.7045 | 1 | 3 |
| caspase-3 | Homo sapiens (human) | Potency | 42.7045 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 31.7639 | 2 | 6 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 22.9253 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 22.3872 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.1189 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.5694 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.2818 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3342 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 25.2002 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.5694 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 237.7810 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 14.9763 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.4124 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 5.7224 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.4634 | 2 | 12 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.0373 | 2 | 6 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 42.8948 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.3478 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 26.1216 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 41.6352 | 8 | 17 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 26.9820 | 2 | 8 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 35.1386 | 6 | 24 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 16.4265 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 1.8294 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.1878 | 2 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 34.7120 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 24.5454 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.4634 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 19.0758 | 2 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.5372 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 48.3747 | 3 | 5 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 40.2364 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 11.8823 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 14.9937 | 2 | 20 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 70.9225 | 2 | 6 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 24.5454 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 0.4467 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 18.5930 | 3 | 5 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 21.5926 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 26.7449 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 11.4239 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 20.8921 | 2 | 6 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.7563 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 9.4562 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 32.9933 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 27.0105 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 26.0918 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 33.8018 | 3 | 10 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 19.8605 | 1 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 9.8527 | 2 | 5 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 24.3027 | 3 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 57.4112 | 2 | 4 |
| polyprotein | Zika virus | Potency | 34.7120 | 1 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 11.9456 | 1 | 7 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.6207 | 1 | 4 |
| PPM1D protein | Homo sapiens (human) | Potency | 11.7086 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 10.1193 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 45.8706 | 2 | 5 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.9336 | 2 | 9 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0947 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.6944 | 3 | 13 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.1635 | 2 | 4 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 20.4054 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 16.7106 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 11.9048 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.9185 | 2 | 16 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 89.1251 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.5099 | 3 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 30.4975 | 6 | 13 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 38.4276 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 64.4679 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 15.1991 | 2 | 9 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 26.0994 | 3 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 19.1498 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 40.2364 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.0008 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 5.0015 | 4 | 4 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.2670 | 5 | 5 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0670 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0239 | 6 | 6 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0083 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.2390 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.1520 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0083 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0340 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0104 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0083 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0340 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0180 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 5.3388 | 4 | 4 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.2450 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.1130 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 20.0500 | 1 | 4 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 6.6683 | 3 | 3 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.1880 | 3 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.0710 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.8750 | 2 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0034 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2025 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 7.7500 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0034 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2025 | 2 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.1800 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 7.7500 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0457 | 2 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2025 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.7070 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0630 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.5567 | 3 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0510 | 1 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0505 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0630 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3953 | 3 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0510 | 1 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.7065 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0630 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.4483 | 3 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0510 | 1 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 130.8167 | 3 | 6 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 3.9465 | 1 | 1 |
| D | Bos taurus (cattle) | IC50 | 0.3385 | 11 | 13 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.4744 | 12 | 12 |
| D | Bos taurus (cattle) | Ki | 0.0037 | 1 | 1 |
| D | Mus musculus (house mouse) | Ki | 0.1010 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.3862 | 8 | 8 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.5690 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.2984 | 11 | 11 |
| D(1B) dopamine receptor | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 0.3385 | 11 | 13 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.1474 | 3 | 3 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0775 | 17 | 20 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.1019 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0590 | 23 | 23 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0268 | 12 | 13 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0820 | 2 | 2 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0134 | 8 | 8 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.0250 | 1 | 1 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1432 | 7 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.0277 | 4 | 4 |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | IC50 | 10.1367 | 3 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0002 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0046 | 3 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.7200 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 2.0490 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 2.0150 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0910 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0220 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.2410 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0860 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.1700 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.0910 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2815 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.0530 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0380 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 5.6810 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.5720 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 2.7615 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.1820 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.0678 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.0353 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0350 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.0002 | 2 | 2 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 20.0500 | 1 | 2 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 37.8000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma brucei brucei | IC50 | 3.4000 | 1 | 1 |
| Trypanothione reductase | Trypanosoma cruzi | IC50 | 13.7500 | 2 | 2 |
| Trypanothione reductase | Trypanosoma cruzi | Ki | 6.6250 | 4 | 4 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2200 | 1 | 1 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 11.2800 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | EC50 | 0.1846 | 4 | 6 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kd | 0.6800 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 0.0502 | 11 | 13 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0171 | 5 | 5 |
| D(2) dopamine receptor | Homo sapiens (human) | Kd | 0.0240 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Kd | 0.7600 | 4 | 5 |
| D(3) dopamine receptor | Homo sapiens (human) | EC50 | 0.0070 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | EC50 | 0.0043 | 2 | 2 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0042 | 3 | 3 |
| Envelope glycoprotein | Ebola virus - Mayinga, Zaire, 1976 | Kd | 118.0000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 11.2800 | 1 | 2 |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | EC50 | 12.4000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 11.2800 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 11.2800 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 11.2800 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 11.2800 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 11.2800 | 1 | 2 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 11.2800 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 11.2800 | 1 | 2 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 11.2800 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| D(1A) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | KL | 0.2060 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | KL | 0.1665 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | ID50 | 0.0390 | 1 | 1 |