Page last updated: 2024-09-28

Granulomatosis, Lymphomatoid

An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.

Synonyms(2)

Synonym
Lymphomatoid Granulomatosis
Granulomatosis, Lymphomatoid

Research Excerpts

Overview

ExcerptReference
"Lymphomatoid granulomatosis is an uncommon disorder with features of vasculitis and lymphoma."( Jenkins, TR; Zaloznik, AJ, 1989)
"Lymphomatoid granulomatosis is a systemic disease marked by a polymorphous cellular infiltrate that is both angiocentric and angiodestructive."( Camisa, C, 1989)
"Polyarthritis in lymphomatoid granulomatosis is rare."( Finlay, AY; McVicar, R; Morton, R; Pitkeathly, DA; Ralston, SH, 1988)
"Lymphomatoid granulomatosis is a rare multisystem disease involving the lungs, skin, and nervous system."( Brodell, RT; Eisen, AZ; Miller, CW, 1986)
"Polyarthritis in lymphomatoid granulomatosis is rare."( Bergin, C; Boyko, W; Hogg, J; Schlappner, O; Stein, HB, 1984)
"A patient with lymphomatoid granulomatosis is reported."( Drasga, RE; Einhorn, LH; Roth, LM; Williams, SD; Wills, ER, 1984)
"Angiocentric lymphomatoid granulomatosis is a rare lymphoproliferative disease, mainly associated with pulmonary manifestation."( Gergely, L; Illés, A; Szakáll, S; Váróczy, L, 2002)
"lymphomatoid granulomatosis is a rare, poor-risk, Epstein-Barr virus related, B cell lymphoproliferative disease."( Oosting-Lenstra, SF; van Marwijk Kooy, M, 2007)
"Lymphomatoid granulomatosis is a rare lymphoproliferative disorder involving the lungs, skin and other organs."( Berg, SE; Chong, EA; Downs, LH; Schuster, SJ; Torigian, DA; Tsai, DE; Wasik, MA, 2008)
"Lymphomatoid granulomatosis is a rare disease."( Lamont, D; Raja, R; Solanki, K; Yung, A, 2010)
"Lymphomatoid granulomatosis is a rare lymphoproliferative disorder composed of rare-to-abundant atypical Epstein Barr virus infected B-cells admixed with numerous reactive T-cells."( Boone, JM; Fan, F; Zhang, D, 2013)
"Lymphomatoid granulomatosis is an uncommon Epstein-Barr virus-positive B-cell lymphoma, an angiocentric-destructive process with a predominant T-cell background."( Cargini, P; Civica, M; Cutilli, T; Di Cola, E; Pontecorvi, E; Sollima, L, 2014)
"Lymphomatoid granulomatosis is a rare lymphoproliferative disorder associated with immunosuppressive therapy in inflammatory bowel disease."( Curieses Luengo, M; López Fernández, E; Varela Trastoy, P, 2019)

Treatment

ExcerptReference
"This case demonstrates that lymphomatoid granulomatosis is still a chemotherapy-resistant disease in some patients despite addition of rituximab."( Oosting-Lenstra, SF; van Marwijk Kooy, M, 2007)

Research

Studies (136)

TimeframeStudies, This Condition (%)All Conditions %
pre-199039 (28.68)23.3326
1990's18 (13.24)12.5806
2000's32 (23.53)18.1394
2010's39 (28.68)28.8240
2020's8 (5.88)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
phenytoin0low10
azathioprine0low60
carmustine0low10
chlorambucil0low30
cimetidine0low10
pentetic acid0low10
diphenhydramine0low10
fluconazole0low10
ketoconazole0low10
mechlorethamine0low20
methenamine0low10
methylphenidate0low10
procarbazine0low10
sulfamethoxazole0low10
sulfasalazine0low10
temozolomide0low10
thiotepa0low10
trimethoprim0low10
prednisolone0low180
prednisone0low350
methionine0low10
cytarabine0low40
methylprednisolone0low50
cladribine0low10
gadolinium0low10
gold0low10
trolamine salicylate0low50
glucoheptonate0low10
zidovudine0low10
etoposide0low50
amikacin0low10
propiconazole0low10
itraconazole0low20
fluorodeoxyglucose f180low90
bexarotene0low10
imatinib mesylate0low20
methotrexate0low250
trimethoprim, sulfamethoxazole drug combination0low20
tacrolimus0low10
cocaine0low10
zithromax0low10
calcitriol0low30
pulmicort0low10
phenylephrine hydrochloride0low20
hydromorphone0low10
gallium0low10
heroin0low10
25-hydroxyvitamin d 20low10
carbon-11 methionine0low10
(dtpa-phe(1))-octreotide0low10
ascorbic acid0low10
cyclosporine0low20
muramidase0low20
acyclovir0medium11
levoleucovorin0low10
dacarbazine0low10
ganciclovir0low10

Protein Targets (754)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain6006
Thymidine kinase 0202
thioredoxin reductase110011
phosphopantetheinyl transferase9009
GLS protein7007
TDP1 protein240024
Smad33003
thyroid stimulating hormone receptor110011
EWS/FLI fusion protein140014
arylsulfatase A7007
euchromatic histone-lysine N-methyltransferase 2180018
activating transcription factor 6100010
Histone H2A.x100010
Bloom syndrome protein isoform 1110011
hemoglobin subunit beta3003
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
lamin isoform A-delta10210021
Solute carrier family 22 member 1 0508
ATP-binding cassette sub-family C member 3027027
Multidrug resistance-associated protein 4027028
Solute carrier family 22 member 60305
Bile salt export pump0606
Bile salt export pump030030
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0305
POU domain, class 2, transcription factor 20002
Cytochrome P450 2C9 010011
Cytochrome P450 2J20606
Disintegrin and metalloproteinase domain-containing protein 172002
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60206
Thymidine kinase 0101
Solute carrier family 22 member 80307
Canalicular multispecific organic anion transporter 1027028
Thymidine kinase0202
estrogen nuclear receptor alpha330033
peripheral myelin protein 22130013
histone acetyltransferase KAT2A isoform 14004
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase100010
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase100010
RAR-related orphan receptor gamma180018
GLI family zinc finger 3240024
AR protein270027
thioredoxin glutathione reductase5005
cytochrome P450 family 3 subfamily A polypeptide 4130013
glucocorticoid receptor [Homo sapiens]210021
retinoic acid nuclear receptor alpha variant 1230023
estrogen-related nuclear receptor alpha260026
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
IDH18008
chromobox protein homolog 1130013
nuclear factor erythroid 2-related factor 2 isoform 28008
thyroid hormone receptor beta isoform 2210021
nuclear factor erythroid 2-related factor 2 isoform 1210021
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin280028
lethal factor (plasmid)2002
Polyphenol oxidase 20203
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0213
Spike glycoprotein100010
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
interleukin 88008
SMAD family member 28008
ATAD5 protein, partial6006
Fumarate hydratase6006
SMAD family member 38008
Microtubule-associated protein tau8008
nuclear receptor subfamily 1, group I, member 3170017
retinoid X nuclear receptor alpha200020
farnesoid X nuclear receptor120012
pregnane X nuclear receptor190019
G120012
polyprotein6006
P531001
peroxisome proliferator-activated receptor delta120012
peroxisome proliferator activated receptor gamma140014
aryl hydrocarbon receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
thyroid stimulating hormone receptor100010
v-jun sarcoma virus 17 oncogene homolog (avian)100010
peripheral myelin protein 22 isoform 15005
cellular tumor antigen p53 isoform a4004
heat shock protein beta-15005
DNA polymerase iota isoform a (long)110011
survival motor neuron protein isoform d100010
cytochrome P450 3A4 isoform 18008
M-phase phosphoprotein 84004
muscleblind-like protein 1 isoform 16006
muscarinic acetylcholine receptor M17007
Gamma-aminobutyric acid receptor subunit pi8109
Voltage-dependent calcium channel gamma-2 subunit110011
Interferon beta170017
HLA class I histocompatibility antigen, B alpha chain 120012
Cellular tumor antigen p53240024
Gamma-aminobutyric acid receptor subunit beta-18109
Gamma-aminobutyric acid receptor subunit delta8109
Gamma-aminobutyric acid receptor subunit gamma-28109
Glutamate receptor 2110011
Gamma-aminobutyric acid receptor subunit alpha-58109
Gamma-aminobutyric acid receptor subunit alpha-38109
Gamma-aminobutyric acid receptor subunit gamma-18109
Gamma-aminobutyric acid receptor subunit alpha-28109
Gamma-aminobutyric acid receptor subunit alpha-48109
Gamma-aminobutyric acid receptor subunit gamma-38109
Gamma-aminobutyric acid receptor subunit alpha-68109
Nuclear receptor ROR-gamma4004
Gamma-aminobutyric acid receptor subunit alpha-18109
Gamma-aminobutyric acid receptor subunit beta-38109
Gamma-aminobutyric acid receptor subunit beta-28109
GABA theta subunit8109
Inositol hexakisphosphate kinase 1120012
ATPase family AAA domain-containing protein 5140014
Ataxin-2160016
Gamma-aminobutyric acid receptor subunit epsilon8109
Protein-arginine deiminase type-40505
cytochrome P450 2C9, partial120012
Luciferase6006
hypoxia-inducible factor 1 alpha subunit7007
USP1 protein, partial9009
PPM1D protein5005
caspase 7, apoptosis-related cysteine protease4004
estrogen receptor 2 (ER beta)100010
progesterone receptor120012
caspase-34004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
nuclear receptor subfamily 1, group I, member 26006
Caspase-72002
vitamin D3 receptor isoform VDRA8008
caspase-32002
nuclear receptor ROR-gamma isoform 1110011
Cytochrome P450 26A10202
Cytochrome P450 1A20102
Cytochrome P450 3A4012015
Retinoic acid receptor alpha0123
Retinoic acid receptor beta0123
Retinoic acid receptor gamma 0123
Retinoic acid receptor RXR-alpha0236
Retinoic acid receptor RXR-alpha0011
Retinoic acid receptor RXR-beta0112
Retinoic acid receptor RXR-beta0022
Retinoic acid receptor RXR-gamma0022
Type-1 angiotensin II receptor0112
Nuclear receptor subfamily 4 group A member 20011
Retinoic acid receptor RXR-gamma0112
Type-2 angiotensin II receptor0011
Oxysterols receptor LXR-beta0011
Retinoic acid receptor RXR-alpha0011
Oxysterols receptor LXR-alpha0011
Sigma non-opioid intracellular receptor 10101
Cytochrome P450 26B10101
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase3003
Vitamin D3 receptor0011
mitogen-activated protein kinase 11001
Vitamin D-binding protein0011
Androgen receptor0303
Cytochrome P450 2D60404
Vitamin D3 receptor0124
Vitamin D3 receptor0113
Cytochrome P450 2C190101
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0213
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
endonuclease IV6006
aldehyde dehydrogenase 1 family, member A1130013
cytochrome P450 2D68008
thyroid hormone receptor beta isoform a4004
huntingtin isoform 24004
Glutathione reductase, mitochondrial0101
Alpha-synuclein1001
Glutathione reductase0101
NFKB1 protein, partial4004
GALC protein5005
Thrombopoietin3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
bromodomain adjacent to zinc finger domain 2B2002
potassium voltage-gated channel subfamily H member 2 isoform d4004
FAD-linked sulfhydryl oxidase ALR0001
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Carbonic anhydrase 120303
Carbonic anhydrase 10707
Carbonic anhydrase 20718
Carbonic anhydrase 90303
Solute carrier organic anion transporter family member 1B30607
alpha-galactosidase2002
cytochrome P450 2C19 precursor4004
DNA polymerase kappa isoform 14004
Solute carrier family 22 member 10101
Solute carrier family 22 member 20203
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
ATP-dependent translocase ABCB10505
ATP-dependent translocase ABCB10618
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10505
Histamine H2 receptor0404
Histamine H1 receptor0023
Histamine H2 receptor4218
Potassium-transporting ATPase subunit beta0101
Aldehyde oxidase0101
Solute carrier family 22 member 10303
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Histamine H4 receptor0202
Solute carrier family 22 member 110103
Solute carrier family 22 member 20303
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
Chain A, BCL-2-RELATED PROTEIN A10022
glp-1 receptor, partial9009
67.9K protein5005
tyrosine-protein kinase Yes2002
relaxin receptor 1 isoform 11001
bcl-2-like protein 11 isoform 10022
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Integrin beta-33003
Integrin alpha-IIb3003
Deoxycytidine kinase0002
Adenosine receptor A30101
Rap guanine nucleotide exchange factor 41001
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
5-hydroxytryptamine receptor 2C0304
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0606
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
D0101
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10002
Sodium-dependent noradrenaline transporter 010010
Sodium-dependent dopamine transporter0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30202
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0303
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50202
Sodium-dependent serotonin transporter0606
Sodium-dependent serotonin transporter0304
5-hydroxytryptamine receptor 7 0101
Gamma-aminobutyric acid receptor subunit alpha-30202
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0102
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0202
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Sodium-dependent dopamine transporter 0606
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Potassium voltage-gated channel subfamily H member 20606
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60202
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0102
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Glutamate receptor ionotropic, NMDA 3B0102
Sigma non-opioid intracellular receptor 10404
Gamma-aminobutyric acid receptor subunit gamma-30202
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0102
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0202
LMP1 [Human herpesvirus 4]0003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
serine/threonine-protein kinase mTOR isoform 13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
transactivating tegument protein VP16 [Human herpesvirus 1]0303
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
Thymidine kinase0101
Thymidylate synthase0203
Thymidine kinase0101
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Deoxynucleoside kinase0101
Chain A, 2-oxoglutarate Oxygenase5005
Matrix metalloproteinase-90202
Inositol monophosphatase 12002
Isocitrate lyase0101
regulator of G-protein signaling 43003
cytochrome P450 2D6 isoform 11001
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
Muscarinic acetylcholine receptor M30202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Histamine H1 receptor0202
5-hydroxytryptamine receptor 2B0202
Histamine N-methyltransferase0001
Sodium channel protein type 5 subunit alpha0202
Nuclear receptor subfamily 3 group C member 3 0202
Calcium release-activated calcium channel protein 10101
Protein orai-20101
Protein orai-30101
Histamine H3 receptor0001
alternatively spliced Trp40011
histone deacetylase 9 isoform 32002
nuclear factor NF-kappa-B p105 subunit isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Guanine nucleotide-binding protein G2002
Gasdermin-D0101
Gasdermin-D0101
Prothrombin0001
Regulatory protein E20011
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Polyunsaturated fatty acid lipoxygenase ALOX150202
DNA topoisomerase 20001
UDP-glucuronosyltransferase 1A1 0102
Serum paraoxonase/arylesterase 10101
Caspase-30101
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
apical membrane antigen 1, AMA11001
unnamed protein product0101
transcriptional regulator ERG isoform 33003
heat shock protein HSP 90-alpha isoform 20002
Histone deacetylase 30101
Rap guanine nucleotide exchange factor 31001
Chymotrypsinogen A0202
Beta-lactamase0202
Steroid 17-alpha-hydroxylase/17,20 lyase0303
Heme oxygenase 1 0101
Lanosterol 14-alpha demethylase0112
Aromatase0303
Cytochrome P450 11B1, mitochondrial0202
Cytochrome P450 11B2, mitochondrial0202
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0202
Histone deacetylase 40101
Cytochrome P450 1440022
Steroid C26-monooxygenase0022
Steroid C26-monooxygenase0022
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
TAR DNA-binding protein 434004
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0325
Sterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0011
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
heat shock protein 90, putative0002
likely tRNA 2'-phosphotransferase0101
ClpP2002
Transitional endoplasmic reticulum ATPase0101
Solute carrier family 22 member 30001
Mu-type opioid receptor0112
Delta-type opioid receptor0303
Kappa-type opioid receptor0112
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
DNA repair protein RAD52 homolog isoform a0001
Tyrosine-protein kinase ABL10224
Cytochrome P450 2C80102
Mast/stem cell growth factor receptor Kit0112
Breakpoint cluster region protein0011
Platelet-derived growth factor receptor alpha0112
Cytochrome P450 3A50102
Estrogen receptor beta0102
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Epoxide hydrolase 10001
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Alpha-2A adrenergic receptor0202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Translocator protein0101
Cytochrome P450 7A1 0101
Estrogen receptor0102
Substance-K receptor0202
Thromboxane-A synthase 0202
Gonadotropin-releasing hormone receptor0112
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0202
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Large neutral amino acids transporter small subunit 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor2002
15-lipoxygenase, partial3003
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
flap endonuclease 13003
snurportin-11001
DNA polymerase eta isoform 11001
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0405
Dihydrofolate reductase0304
Dihydrofolate reductase 0303
Dihydrofolate reductase0303
Dihydrofolate reductase0101
Dihydrofolate reductase0405
Thymidylate synthase0101
Thymidylate synthase0303
Bifunctional dihydrofolate reductase-thymidylate synthase0303
High mobility group protein B10022
Dihydrofolate reductase0303
Thymidylate synthase0202
Dihydrofolate reductase0426
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0303
Folate receptor beta0101
Folate receptor alpha0101
Dihydrofolate reductase0506
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0303
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0202
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0203
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0303
Solute carrier family 22 member 60202
Dihydrofolate reductase0203
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Broad substrate specificity ATP-binding cassette transporter ABCG20203
nonstructural protein 13003
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor08316
Glycine receptor subunit alpha-10808
Androgen receptor0707
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Nuclear receptor subfamily 1 group I member 20011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Gamma-aminobutyric acid 0101
cytochrome P450 2C9 precursor2002
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Sodium channel protein type 2 subunit alpha0101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 9 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit pi0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-10101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0303
Progesterone receptor0304
Glucocorticoid receptor0213
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0325
Glutamine synthetase0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0303
pregnane X receptor2002
glucocerebrosidase1001
Interleukin-50101
Interleukin-50101
Interleukin-5 receptor subunit alpha0101
chaperonin-containing TCP-1 beta subunit homolog1001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Albumin0112
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 70002
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
ATP-dependent 6-phosphofructokinase0101
Dihydropteroate synthase0101
Endothelin-1 receptor0101
Protease 0224
Chain A, Glutathione S-transferase0101
Replicase polyprotein 1ab0011
Solute carrier organic anion transporter family member 2B1 0202
Tumor necrosis factor0011
Interstitial collagenase0101
Fibroblast growth factor 10011
Mitogen-activated protein kinase 10101
Caspase-10101
Flavin reductase (NADPH)0011
Cystine/glutamate transporter0101
Solute carrier organic anion transporter family member 1B10303
UDP-glucuronosyltransferase 2B70002
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
polyadenylate-binding protein 10101
Tyrosine-protein kinase ABL20101
serine/threonine-protein kinase PLK12002
Cytochrome P450 2B10101
Cytochrome P450 2B60101
Chain A, Dihydrofolate Reductase0011
Chain A, Dihydrofolate reductase0101
Chain A, dihydrofolate reductase (DHFR)0101
Chain A, Dihydrofolate reductase0101
Chain A, Dihydrofolate reductase0101
Dihydrofolate reductase 0102
Dihydrofolate reductase type 10102
Dihydrofolate reductase0101
Dihydrofolate reductase0101
NH(3)-dependent NAD(+) synthetase0101
Dihydrofolate reductase type 1 from Tn40030101
Dipeptidyl peptidase 40101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Metabotropic glutamate receptor 50101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Trace amine-associated receptor 50011
Dihydrofolate reductase 0101
Dihydrofolate reductase 0101
pyruvate kinase PKM isoform a1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Protein kinase C beta type0101
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Reverse transcriptase/RNaseH 0126
Thymidine kinase0102
Solute carrier family 22 member 70001
streptokinase A precursor0011
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]