Page last updated: 2024-09-27

Bovine Respiratory Disease Complex

A multifactorial disease of CATTLE resulting from complex interactions between environmental factors, host factors, and pathogens. The environmental factors act as stressors adversely affecting the IMMUNE SYSTEM and other host defenses and enhancing transmission of infecting agents.

Synonyms(1)

Synonym
Bovine Respiratory Disease Complex

Research

Studies (68)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (2.94)23.3326
1990's0 (0.00)12.5806
2000's13 (19.12)18.1394
2010's43 (63.24)28.8240
2020's10 (14.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low20
nitrites0low10
sulfanilamide0low10
tyrosine0low10
d-alpha tocopherol0low10
trolamine salicylate0low10
thiamphenicol0medium51
clonixin0medium22
flunixin0medium11
flunixin meglumine0medium11
cephalosporin c0medium72
enrofloxacin0medium42
danofloxacin0low30
fibrinogen0low10
florfenicol0medium51
retinol0low10
cocaine0low10
phenylephrine hydrochloride0low30
tulathromycin0medium197
dextrothyroxine0low10
ceftiofur0medium72
tildipirosin0medium21
interleukin-80low10
tilmicosin0medium73
tylosin0medium94
leukotoxin0low10
ascorbic acid0medium21
chlortetracycline0low10
oxytetracycline, anhydrous0low50
gamithromycin0medium74

Protein Targets (352)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase3003
RAR-related orphan receptor gamma7007
GLI family zinc finger 34004
AR protein8008
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 15005
estrogen-related nuclear receptor alpha100010
estrogen nuclear receptor alpha110011
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH13003
euchromatic histone-lysine N-methyltransferase 24004
chromobox protein homolog 16006
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 24004
nuclear factor erythroid 2-related factor 2 isoform 15005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin7007
lethal factor (plasmid)1001
lamin isoform A-delta105005
Polyphenol oxidase 20102
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein3003
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
P2Y purinoceptor 120101
Protein-arginine deiminase type-40202
Luciferase2002
TDP1 protein7007
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
serine/threonine-protein kinase PLK12002
nuclear receptor ROR-gamma isoform 12002
peripheral myelin protein 223003
Cellular tumor antigen p536006
UDP-glucuronosyltransferase 2B70001
UDP-glucuronosyltransferase 1A30001
Dihydroorotate dehydrogenase (quinone), mitochondrial0202
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0202
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
5-hydroxytryptamine receptor 2C0303
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
D0101
5-hydroxytryptamine receptor 1A0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10001
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0303
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0203
5-hydroxytryptamine receptor 7 0101
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0102
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Sodium-dependent dopamine transporter 0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Potassium voltage-gated channel subfamily H member 20101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0102
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0102
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0102
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
USP1 protein, partial4004
Microtubule-associated protein tau5005
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
heat shock protein beta-12002
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 32002
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
histone acetyltransferase KAT2A isoform 12002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Ferritin light chain1001
Chain A, Cruzipain2002
endonuclease IV1001
thioredoxin reductase4004
nonstructural protein 12002
glucocerebrosidase1001
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d2002
DNA polymerase beta2002
mitogen-activated protein kinase 12002
DNA polymerase iota isoform a (long)4004
M-phase phosphoprotein 81001
neuropeptide S receptor isoform A1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase3003
SMAD family member 22002
SMAD family member 32002
aldehyde dehydrogenase 1 family, member A13003
bromodomain adjacent to zinc finger domain 2B2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
streptokinase A precursor0022
Bile salt export pump0202
TAR DNA-binding protein 432002
nuclear receptor subfamily 1, group I, member 33003
transcriptional regulator ERG isoform 32002
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
ATAD5 protein, partial1001
glycogen synthase kinase-3 alpha0001
estrogen receptor 2 (ER beta)2002
cytochrome P450 2D63003
thyroid stimulating hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)2002
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
Carbonic anhydrase 10305
Carbonic anhydrase 20316
Carbonic anhydrase 40203
Carbonic anhydrase0203
Carbonic anhydrase 150203
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
WRN1001
phosphopantetheinyl transferase2002
GLS protein1001
Valosin-containing protein0101
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
regulator of G-protein signaling 41001
pregnane X nuclear receptor3003
Histone H2A.x1001
lysosomal alpha-glucosidase preproprotein2002
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform a1001
microphthalmia-associated transcription factor isoform 90101
flap endonuclease 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
eukaryotic translation initiation factor 4E isoform 10101
DNA polymerase kappa isoform 11001
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Neuronal acetylcholine receptor subunit alpha-42002
Neuronal acetylcholine receptor subunit beta-22002
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
glp-1 receptor, partial1001
GALC protein1001
peroxisome proliferator activated receptor gamma2002
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
interleukin 81001
15-lipoxygenase, partial1001
pregnane X receptor1001
thyroid stimulating hormone receptor2002
retinoid X nuclear receptor alpha4004
peroxisome proliferator-activated receptor delta1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Alpha-synuclein0101
Nuclear receptor ROR-gamma1001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Disintegrin and metalloproteinase domain-containing protein 172002
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
Carbonic anhydrase 0001
Carbonic anhydrase 0101
EWS/FLI fusion protein2002
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 120102
Voltage-dependent calcium channel gamma-2 subunit1001
Carbonic anhydrase 20112
Cholinesterase0101
Carbonic anhydrase 30102
Glutamate receptor 21001
Acetylcholinesterase0101
Carbonic anhydrase 60203
Carbonic anhydrase 5A, mitochondrial0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0204
Carbonic anhydrase 70102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 90203
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0102
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0102
Carbonic anhydrase 130101
Carbonic anhydrase 40101
Carbonic anhydrase 130101
Protein argonaute-20011
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0103
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Estrogen receptor0011
Estrogen receptor beta0011
Canalicular multispecific organic anion transporter 10101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Adenosine receptor A10001
Adenosine receptor A2a0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase-like protein, putative0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]