Page last updated: 2024-12-11

diferuloylputrescine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

diferuloylputrescine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5321825
CHEMBL ID1088758
CHEBI ID173179
MeSH IDM0417710

Synonyms (28)

Synonym
diferuloylputrescine
(e)-3-(4-hydroxy-3-methoxyphenyl)-n-[4-[[(e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]butyl]prop-2-enamide
42369-86-8
CHEBI:173179
terrestribisamide
CHEMBL1088758
n,n'-diferuloylputrescine
terrestribisamide, (e,e)-
bis-ferulamidobutane
(e,e)-terrestribisamide
2-propenamide, n,n'-1,4-butanediylbis(3-(4-hydroxy-3-methoxyphenyl)-, (2e,2'e)-
91000-13-4
unii-576nvq5724
sid corn dfp
576nvq5724 ,
2-propenamide, n,n'-1,4-butanediylbis(3-(4-hydroxy-3-methoxyphenyl)-, (e,e)-
bis-ferulamidobutane [inci]
trans-n,n'-diferuloylputrescine
(2e)-3-(4-hydroxy-3-methoxyphenyl)-n-(4-([(2e)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoyl]amino)butyl)-2-propenamide #
CHEMZHJQHCVLFI-MKICQXMISA-N
(2e)-3-(4-hydroxy-3-methoxyphenyl)-n-{4-[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamido]butyl}prop-2-enamide
DTXSID30238359
n,n'-diferuloyl-putrescine
Q27261475
diferuloyl putrescine
bdbm50520916
compound np-016222
AKOS040738661

Research Excerpts

Effects

ExcerptReferenceRelevance
"Diferuloylputrescine has been found in a variety of plant species, and recent work has provided evidence of its covalent bonding into lignin. "( Density functional theory study on the coupling and reactions of diferuloylputrescine as a lignin monomer.
Del Río, JC; Elder, T; Kim, H; Ralph, J; Rencoret, J, 2022
)
2.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxycinnamic acidAny member of the class of cinnamic acids carrying one or more hydroxy substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)108.40000.03403.987110.0000AID1585452
TyrosinaseMus musculus (house mouse)IC50 (µMol)88.40000.03002.21045.2300AID1585454
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1585456Metal chelating activity of the compound assessed as Cu2+-compound complex formation at 50 uM after 10 mins by UV-Vis spectrophotometric analysis2018Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID1585454Inhibition of tyrosinase in mouse B16-F1 cells2018Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID1585455Antimelanogenic activity in mouse B16-F1 cells assessed as reduction in alpha-MSH-stimulated melanin production preincubated for 72 hrs followed by alpha-MSH-stimulation and measured after 2 hrs2018Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID1585457Antioxidant activity assessed as DPPH free radical scavenging activity after 10 mins2018Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID1585452Inhibition of mushroom tyrosinase2018Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID1585453Cytotoxicity against mouse B16-F1 cells at 100 to 200 uM after 72 hrs by MTT assay2018Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
AID475504Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
AID475505Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (12.50%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]