An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
| Member | Definition | Class |
|---|
| 17-octadecynoic acid | An acetylenic fatty acid that is octadecanoi acid (stearic acid) which has been doubly dehydrogenated at positions 17 and 18 to give the corresponding alkynoic acid. | octadec-17-ynoic acid |
| 3,3'-diindolylmethane | | 3,3'-diindolylmethane |
| 4-(1-((5-((2,6-dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine | An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine. | dafadine A |
| amentoflavone | A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. | amentoflavone |
| beauvericin | A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues. | beauvericin |
| carbon monoxide | A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas. | carbon monoxide |
| cimetidine | A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. | cimetidine |
| cinacalcet | A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. | cinacalcet |
| cinacalcet hydrochloride | A hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride. | cinacalcet hydrochloride |
| cobicistat | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications.. | cobicistat |
| dafadine B | An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2-chloro-4-fluorophenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine | dafadine B |
| dafadine C | An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-difluorophenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine. | dafadine C |
| dafadine D | An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(3-trifluoromethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine. | dafadine D |
| dafadine O | An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(3-methoxyphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine. | dafadine O |
| eupatorin | A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups. | eupatorin |
| famotidine | | famotidine |
| famotidine | | famotidine |
| fluconazole | A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis. | fluconazole |
| itraconazole | An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis. | itraconazole |
| paroxetine | A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. | paroxetine |
| paroxetine hydrochloride | The hydrochloride salt of paroxetine. It is an antidepressant drug. | paroxetine hydrochloride |
| paroxetine maleate | A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. | paroxetine maleate |
| quinidine | A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | quinidine |
| sulfamethoxazole | An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position. | sulfamethoxazole |
| sulfaphenazole | A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent. | sulfaphenazole |
| terbinafine | A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections. | terbinafine |
| terbinafine hydrochloride | A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride. | terbinafine hydrochloride |
| voriconazole | A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4. | voriconazole |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 14.6509 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 101.2440 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 14.5983 | 2 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.9510 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 21.1481 | 1 | 7 |
| AR protein | Homo sapiens (human) | Potency | 17.0644 | 8 | 21 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.3278 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 3.3444 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 15.4568 | 2 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 30.6446 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 13.1797 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 28.3927 | 2 | 3 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 14.6892 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0016 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 64.7758 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.2864 | 2 | 8 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 22.1060 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 21.5662 | 2 | 7 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 12.9244 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 30.6694 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 31.4875 | 1 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 11.4721 | 2 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 22.5453 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 50.8277 | 2 | 8 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 32.1841 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 4.3458 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.6943 | 1 | 11 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 5.9056 | 1 | 10 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 18.0466 | 2 | 19 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.9704 | 2 | 12 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 18.4125 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 26.1216 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 25.7953 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 75.1526 | 1 | 9 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 53.8083 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.1163 | 10 | 34 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 13.6885 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 27.2383 | 9 | 24 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 20.3944 | 1 | 14 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 10.8491 | 4 | 11 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.7926 | 1 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 46.2116 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 23.0094 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 10.6943 | 1 | 11 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.9367 | 1 | 10 |
| geminin | Homo sapiens (human) | Potency | 11.8883 | 2 | 15 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 12.9559 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 15.5700 | 1 | 9 |
| GLS protein | Homo sapiens (human) | Potency | 13.5981 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 14.2359 | 3 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 16.8036 | 1 | 2 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 20.2781 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 24.3110 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.6551 | 2 | 15 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 46.3760 | 2 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.6943 | 1 | 11 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 17.9008 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 19.8907 | 2 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 17.7618 | 1 | 6 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.6943 | 1 | 22 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 14.6510 | 3 | 16 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.2241 | 1 | 8 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 18.6966 | 1 | 2 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 34.2188 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.1400 | 2 | 8 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.3379 | 2 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 8.5398 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 10.0000 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 30.1433 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.0144 | 3 | 7 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.4866 | 1 | 5 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 17.4356 | 2 | 5 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.3529 | 2 | 11 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.0776 | 3 | 12 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 48.2874 | 1 | 4 |
| Parkin | Homo sapiens (human) | Potency | 33.5278 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 69.6219 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 12.3889 | 2 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 61.0690 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 25.1728 | 4 | 6 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 32.3230 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 57.7284 | 2 | 6 |
| PINK1 | Homo sapiens (human) | Potency | 33.5278 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 6.2272 | 1 | 4 |
| polyprotein | Zika virus | Potency | 23.0094 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 25.1189 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 10.3771 | 1 | 5 |
| PPM1D protein | Homo sapiens (human) | Potency | 29.4107 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 19.6600 | 3 | 9 |
| progesterone receptor | Homo sapiens (human) | Potency | 23.8393 | 2 | 6 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 85.3973 | 1 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.0284 | 2 | 7 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 21.7147 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.1337 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 27.3002 | 3 | 8 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.5218 | 2 | 7 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 20.3239 | 4 | 4 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 22.4852 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 35.6849 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 35.6849 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 25.3988 | 1 | 9 |
| snurportin-1 | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 32.6448 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.5957 | 1 | 4 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.2227 | 2 | 31 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 94.5626 | 1 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 14.2191 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.5588 | 2 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 18.1083 | 4 | 11 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 2 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 2.7436 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 43.2397 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 6.2272 | 1 | 4 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 6.2272 | 1 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.9891 | 2 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 20.2843 | 2 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 25.5744 | 1 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 36.2530 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 16.8036 | 1 | 2 |
| Vpr | Human immunodeficiency virus 1 | Potency | 39.8107 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Bos taurus (cattle) | IC50 | 29.0000 | 1 | 1 |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Sus scrofa (pig) | Ki | 4.0940 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 4.7000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 2.5550 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 113.8000 | 1 | 2 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 30.3100 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | Ki | 155.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.1078 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | Ki | 0.0004 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.0907 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 5.7029 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 2.1386 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.3100 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.3100 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.3100 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 10.4293 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 8.5445 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 18.2500 | 2 | 2 |
| Aromatase | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei | IC50 | 57.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 47.9154 | 9 | 13 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 30.7500 | 4 | 8 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 202.5886 | 7 | 7 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 1,000.0000 | 2 | 2 |
| Beta-adrenergic receptor kinase 1 | Bos taurus (cattle) | IC50 | 1.1533 | 3 | 3 |
| Beta-adrenergic receptor kinase 1 | Homo sapiens (human) | IC50 | 4.5600 | 6 | 6 |
| Beta-lactamase | Escherichia coli K-12 | IC50 | 400.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 1.5400 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 292.0569 | 4 | 16 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 59.0000 | 1 | 1 |
| C-8 sterol isomerase | Saccharomyces cerevisiae S288C | Ki | 50.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 0.9224 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0453 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.1715 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 0.6772 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.0579 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 0.9388 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 1.4295 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 5.3282 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 0.0982 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.1263 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cholesterol 24-hydroxylase | Homo sapiens (human) | IC50 | 0.0345 | 2 | 2 |
| Cholesterol 24-hydroxylase | Homo sapiens (human) | Ki | 0.0110 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 7.3700 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 1.2300 | 1 | 1 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 | 400.0000 | 1 | 1 |
| cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.2100 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0350 | 2 | 2 |
| Cytochrome P450 2B6 | Homo sapiens (human) | IC50 | 12.2000 | 1 | 1 |
| Cytochrome P450 2C18 | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 177.9000 | 3 | 3 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 15.2173 | 37 | 38 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 10.9000 | 2 | 3 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 19.9000 | 1 | 1 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 2.8000 | 1 | 1 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 26.9000 | 1 | 1 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 2.1817 | 49 | 50 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 12.4061 | 6 | 7 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 110.4203 | 8 | 11 |
| Cytochrome P450 4F2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytosolic phospholipase A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.2410 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 0.0362 | 2 | 2 |
| Delta-type opioid receptor | Sus scrofa (pig) | Ki | 0.0365 | 1 | 1 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 0.1000 | 1 | 1 |
| Dihydropteroate synthase | Escherichia coli K-12 | IC50 | 4.7000 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | IC50 | 223.3333 | 3 | 3 |
| exodeoxyribonuclease V subunit RecB | Escherichia coli str. K-12 substr. MG1655 | IC50 | 106.4380 | 2 | 2 |
| exodeoxyribonuclease V subunit RecC | Escherichia coli str. K-12 substr. MG1655 | IC50 | 106.4380 | 2 | 2 |
| exodeoxyribonuclease V subunit RecD | Escherichia coli str. K-12 substr. MG1655 | IC50 | 106.4380 | 2 | 2 |
| G protein-coupled receptor kinase 5 | Bos taurus (cattle) | IC50 | 150.7250 | 4 | 4 |
| G protein-coupled receptor kinase 5 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 281,838.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 281,838.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 281,838.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0149 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 0.0060 | 2 | 2 |
| Group 10 secretory phospholipase A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 | 90.0000 | 1 | 2 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 | 90.0000 | 1 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 1.0200 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.0484 | 8 | 9 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.3020 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 0.9161 | 5 | 7 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 2 |
| Histidine-rich protein PFHRP-II | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 325.0000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| hypothetical protein SA1422 | Staphylococcus aureus subsp. aureus N315 | IC50 | 19.3900 | 2 | 2 |
| Lanosterol 14-alpha demethylase | Candida albicans SC5314 | IC50 | 0.1296 | 5 | 5 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 2 |
| likely tRNA 2'-phosphotransferase | Candida albicans SC5314 | IC50 | 49.7510 | 1 | 1 |
| M1-family alanyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 108.3900 | 1 | 1 |
| Malate dehydrogenase, cytoplasmic | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 2.5800 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 1.6341 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 4.2120 | 3 | 5 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 37.6000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 122.1000 | 1 | 8 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.1450 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0350 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.5320 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.1890 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.1790 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0380 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.2440 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0340 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.1230 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0890 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 1.2700 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 10.4293 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 8.5445 | 1 | 1 |
| nucleotide-binding oligomerization domain-containing protein 2 isoform 1 | Homo sapiens (human) | IC50 | 17.0580 | 1 | 1 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 2.8067 | 3 | 3 |
| P2X purinoceptor 4 | Rattus norvegicus (Norway rat) | IC50 | 2.4500 | 2 | 2 |
| Phospholipase A2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Phospholipase A2, membrane associated | Homo sapiens (human) | IC50 | 23.8000 | 1 | 1 |
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | IC50 | 6.2300 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 0.1023 | 3 | 3 |
| Poly [ADP-ribose] polymerase 2 | Homo sapiens (human) | IC50 | 10.3000 | 2 | 2 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily A member 3 | Homo sapiens (human) | IC50 | 31.9000 | 1 | 1 |
| Potassium voltage-gated channel subfamily A member 5 | Homo sapiens (human) | IC50 | 7.3000 | 1 | 1 |
| Potassium voltage-gated channel subfamily D member 2 | Rattus norvegicus (Norway rat) | IC50 | 2.2000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 7.7672 | 7 | 7 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 8.5445 | 1 | 1 |
| Potassium-transporting ATPase alpha chain 1 | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| Potassium-transporting ATPase subunit beta | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| Procathepsin L | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 30.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | Ki | 0.0101 | 1 | 1 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 220.0000 | 1 | 1 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Quinolone resistance protein NorA | Staphylococcus aureus | IC50 | 7.0000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 8.3000 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 8.3000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 8.3000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 8.3000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 8.3000 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 13.8000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 13.8000 | 2 | 2 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 119.0000 | 1 | 1 |
| Rhodopsin kinase GRK1 | Bos taurus (cattle) | IC50 | 243.1750 | 4 | 4 |
| Rhodopsin kinase GRK1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 2.9631 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 1.2452 | 1 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 11.7500 | 2 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.8492 | 2 | 5 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | Ki | 0.4600 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.4000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.6720 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.4670 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Mus musculus (house mouse) | Ki | 0.0200 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.4385 | 2 | 3 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.4238 | 2 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0007 | 4 | 4 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0003 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.0002 | 9 | 9 |
| Sodium-dependent serotonin transporter | Mus musculus (house mouse) | Ki | 0.0004 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 3 | 4 |
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | IC50 | 0.5900 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 170.8500 | 2 | 2 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 8.7667 | 2 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 137.2400 | 5 | 5 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 91.7500 | 1 | 2 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | IC50 | 2,000.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 29.5500 | 2 | 2 |
| Solute carrier family 22 member 2 | Mus musculus (house mouse) | IC50 | 8.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 193.8000 | 2 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 928.5000 | 1 | 2 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 75.5000 | 2 | 3 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 10.7000 | 1 | 1 |
| Solute carrier family 22 member 4 | Rattus norvegicus (Norway rat) | IC50 | 1,500.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 492.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | IC50 | 92.4000 | 1 | 1 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | IC50 | 166.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 176.5000 | 1 | 2 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | Ki | 46.8000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 9.2700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 120.0000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 8.3000 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 8.3000 | 1 | 1 |
| Squalene monooxygenase | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Squalene monooxygenase | Homo sapiens (human) | Ki | 0.0300 | 1 | 1 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 93.0000 | 1 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | IC50 | 200.0000 | 2 | 2 |
| Sterol 14-alpha demethylase | Trypanosoma cruzi strain CL Brener | IC50 | 0.8800 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 2.0800 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 0.5350 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.6596 | 1 | 1 |
| tumor necrosis factor | Homo sapiens (human) | IC50 | 9.1435 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 7.4000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 7.8000 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 287.8182 | 1 | 11 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 287.8182 | 1 | 11 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 287.8182 | 1 | 11 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 287.8182 | 1 | 11 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 287.8182 | 1 | 11 |
| unnamed protein product | Aspergillus oryzae RIB40 | IC50 | 49.7510 | 1 | 1 |
| Valosin-containing protein | Homo sapiens (human) | IC50 | 36.3280 | 2 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 16.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 111.0800 | 4 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 141.5000 | 3 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 141.5000 | 3 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 141.5000 | 3 | 3 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 35.3000 | 1 | 1 |