An agonist that enhances the action of smoothened (SMO) receptor.
ChEBI ID: 131809
| Member | Definition | Class |
|---|---|---|
| clobetasol | A 3-oxo-Delta(1),Delta(4)-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha positions, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis. | clobetasol |
| halcinonide | Halcinonide | |
| purmorphamine | A member of the class of purines that is purine substituted at C-2 by a 1-naphthyloxy group, at C-4 by a 4-morpholinophenylamino group, and at N-9 by a cyclohexyl group. | purmorphamine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 241 (15.46) | 18.7374 |
| 1990's | 222 (14.24) | 18.2507 |
| 2000's | 363 (23.28) | 29.6817 |
| 2010's | 579 (37.14) | 24.3611 |
| 2020's | 154 (9.88) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 412 (24.35%) | 5.53% |
| Reviews | 122 (7.21%) | 6.00% |
| Case Studies | 529 (31.26%) | 4.05% |
| Observational | 4 (0.24%) | 0.25% |
| Other | 625 (36.94%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 3.2880 | 9 | 13 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 10.0078 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 10.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.7407 | 1 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.1587 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.0018 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.4518 | 4 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 24.6745 | 3 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0019 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 6.7407 | 1 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 4.5049 | 3 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0029 | 3 | 6 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.7407 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.7407 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 6.7407 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 29.0122 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.0099 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 1.0000 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 21.3138 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 7.2256 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 23.6543 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 15.0593 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 8.4172 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.0531 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 42.5266 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8850 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.5900 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.0016 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0007 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0007 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0007 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0007 | 1 | 1 |
| Smoothened homolog | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Smoothened homolog | Mus musculus (house mouse) | EC50 | 0.8000 | 1 | 1 |
| Sonic hedgehog protein | Mus musculus (house mouse) | EC50 | 1.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| interferon gamma precursor | Homo sapiens (human) | AC50 | 14.5550 | 2 | 2 |