A drug that has a strengthening effect on the heart or that can increase cardiac output.
| Member | Definition | Class |
|---|
| acetyldigitoxin | A cardenolide glycoside compound consisting of digitoxin having an acetyl substituent at the 3-position on the D-ribo-hexopyranosyl residue at the non-reducing end. | 3'''-O-acetyldigitoxin |
| aminophylline | A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. | aminophylline |
| arbutamine | | arbutamine |
| bucladesine | A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP. | bucladesine |
| bufalin | A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo. | bufalin |
| carbachol | | carbachol |
| cassaine | A tricyclic diterpenoid isolated from several plant species of the genus Erythrophleum. | cassaine |
| colforsin daropate | A carboxylic ester resuting from the formal condensation of the carboxy group of N,N-dimethyl-beta-alanine with the 6-hydroxy group of forskolin. It is an adenylate cyclase activator. | colforsin daropate |
| corlanor | A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure. | ivabradine hydrochloride |
| deslanoside | A cardenolide glycoside that is lanatoside C with the acetoxy group replaced by a hydroxy group. | deslanoside |
| diazoxide | A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. | diazoxide |
| digoxin | A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small. | digoxin |
| dobutamine | A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure. | dobutamine |
| dobutamine hydrochloride | The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the management of acute heart failure. | dobutamine hydrochloride |
| isoproterenol | A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. | isoprenaline |
| ivabradine | A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure. | ivabradine |
| milrinone | A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. | milrinone |
| neriifolin | A cardenolide glycoside that is digitoxigenin in which the hydroxy goup at position 3 has been converted to its (6-deoxy-3-O-methyl-alpha-L-glucopyranoside derivative. Found in the seeds of Cerbera odollamand in Thevetia ahouia and Thevitia neriifolia. | neriifolin |
| or 1259 | | levosimendan |
| ouabain | A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus. | ouabain |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| pimobendan | | pimobendan |
| propionylcarnitine | An O-acylcarnitine compound having propanoyl as the acyl substituent. | O-propanoylcarnitine |
| solasodine | An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills. | solasodine |
| sulmazole | An imidazopyridine that is 1H-imidazo[4,5-b]pyridine which is substituted at position 2 by a 2-methoxy-4-(methylsulfinyl)phenyl group. An A1 adenosine receptor antagonist, it was formerly used as a cardiotonic agent. | sulmazole |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 24.3965 | 1 | 3 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 23.9341 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 17.8815 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 33.2996 | 4 | 11 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 3.2103 | 1 | 8 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.2677 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 10.0000 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 4.8874 | 12 | 71 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 20.3134 | 2 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 5.3582 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.4297 | 3 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 9.5742 | 2 | 11 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 17.3285 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 5.2707 | 2 | 17 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 1.2995 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0116 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 31.6704 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 13.3332 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 31.6704 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 13.3332 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 9.7010 | 3 | 12 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 0.1790 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 27.0906 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 14.4923 | 2 | 7 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 22.4748 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 0.2239 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 18.9338 | 2 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 14.8714 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 18.9338 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 72.2839 | 2 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.3676 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 47.3544 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.0436 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.7314 | 1 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.4164 | 2 | 3 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 18.4927 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 2.5500 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 25.1189 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 6.0009 | 11 | 70 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 7.0812 | 2 | 12 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 4.0606 | 10 | 56 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 9.8384 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 20.0683 | 4 | 18 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 4.0766 | 4 | 13 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 14.0585 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 12.3676 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 6.3034 | 3 | 18 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 26.5023 | 3 | 13 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 6.4495 | 2 | 5 |
| GLS protein | Homo sapiens (human) | Potency | 6.7526 | 2 | 6 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.1068 | 4 | 16 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 5.7031 | 1 | 6 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 3.4620 | 1 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 20.5348 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 19.9826 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 44.8017 | 2 | 5 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.3676 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 20.1548 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.2512 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 19.4723 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 3.4620 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.3676 | 1 | 10 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 7.3944 | 3 | 16 |
| interleukin 8 | Homo sapiens (human) | Potency | 0.2985 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.4648 | 2 | 12 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.0316 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 7.6334 | 1 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 6.6226 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.5481 | 2 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 46.4497 | 1 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 6.0744 | 4 | 14 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.0940 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 2.7568 | 1 | 7 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 9.4392 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.7571 | 1 | 6 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 7.2106 | 3 | 18 |
| P53 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.4475 | 1 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 72.5206 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 8.3873 | 5 | 26 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 5.5025 | 5 | 25 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 43.9301 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| polyprotein | Zika virus | Potency | 14.0585 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.0300 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 6.2103 | 1 | 6 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 10.0953 | 3 | 10 |
| progesterone receptor | Homo sapiens (human) | Potency | 2.6470 | 2 | 10 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.6040 | 2 | 11 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 24.3448 | 1 | 5 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 9.1312 | 1 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 24.8596 | 3 | 8 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.9501 | 4 | 20 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 15.7922 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 5.6379 | 2 | 12 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 5.6379 | 2 | 12 |
| Smad3 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 3.4620 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 22.9619 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.9044 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 10.6896 | 2 | 26 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 3.9811 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 15.9281 | 3 | 10 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.4029 | 2 | 5 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 1.7939 | 3 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 6.6035 | 7 | 31 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 3.3786 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 60.4566 | 2 | 2 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 0.3758 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 7.1196 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 6.8326 | 4 | 24 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 5.7031 | 1 | 6 |
| Vpr | Human immunodeficiency virus 1 | Potency | 12.5893 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3',5'-cyclic-AMP phosphodiesterase | Sus scrofa (pig) | IC50 | 13.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.3830 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.3800 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.9332 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.1622 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.9207 | 3 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 1.2589 | 1 | 1 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 1.2589 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 20.8000 | 2 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.1140 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.9207 | 3 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.3900 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 7.2200 | 3 | 3 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 2.9660 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.8720 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 7.2200 | 3 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.3900 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 7.2200 | 3 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | IC50 | 470.5000 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 50.0000 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 50.0000 | 4 | 4 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | IC50 | 470.5000 | 4 | 4 |
| Aurora kinase A | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 1.1385 | 1 | 2 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.9670 | 2 | 3 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | Ki | 0.2200 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 4.5833 | 3 | 3 |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | IC50 | 0.6667 | 2 | 3 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 0.8815 | 1 | 2 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 0.3235 | 6 | 7 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.6761 | 1 | 1 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Ki | 0.1100 | 2 | 2 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2125 | 2 | 2 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 18.6209 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 575.1300 | 5 | 10 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Homo sapiens (human) | IC50 | 393.5000 | 8 | 8 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | IC50 | 393.5000 | 8 | 8 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Homo sapiens (human) | IC50 | 393.5000 | 8 | 8 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 35.4333 | 2 | 3 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1.9200 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 4.3500 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 9.5300 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 12.0200 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 0.3900 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.4800 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 7.4000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 8.9800 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 0.7300 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 0.8900 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 9.4700 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.3000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 9.8200 | 1 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 166.0300 | 9 | 10 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 41.2706 | 28 | 32 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | Ki | 0.1500 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 44.6278 | 24 | 27 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | Ki | 0.1500 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Bos taurus (cattle) | IC50 | 5.0000 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 55.3400 | 5 | 6 |
| Chain H, Igg2b-kappa 40-50 Fab (heavy Chain) | Mus musculus (house mouse) | Ki | 0.0028 | 1 | 1 |
| Chain L, Igg2b-kappa 40-50 Fab (light Chain) | Mus musculus (house mouse) | Ki | 0.0028 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 20.5867 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 11.0150 | 2 | 2 |
| Cytochrome P450 3A5 | Homo sapiens (human) | IC50 | 2.7600 | 1 | 1 |
| Cytochrome P450 3A7 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 30.0000 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 4.9850 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 3.1965 | 2 | 2 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 2.9000 | 1 | 1 |
| Dual specificity protein kinase TTK | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 5.5510 | 1 | 1 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Homo sapiens (human) | IC50 | 50.1500 | 1 | 2 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 0.1645 | 2 | 2 |
| Inner centromere protein | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Kruppel-like factor 5 | Homo sapiens (human) | IC50 | 0.0832 | 3 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 132.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | IC50 | 150.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Ki | 67.5911 | 4 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 41.1368 | 4 | 4 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 13.4425 | 8 | 14 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 135.4539 | 18 | 18 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | Ki | 4.7822 | 5 | 5 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 10.8368 | 12 | 16 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 17.6728 | 7 | 7 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 10.9373 | 8 | 11 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.2977 | 15 | 15 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 25.4284 | 10 | 13 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 149.3980 | 8 | 10 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 30.1886 | 10 | 10 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 13.8161 | 28 | 31 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 2.0626 | 4 | 4 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 12.6900 | 7 | 9 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 6.8330 | 13 | 13 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 15.5317 | 8 | 11 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 25.2000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 14.2475 | 6 | 8 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 37.6948 | 13 | 13 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 16.8249 | 7 | 10 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Ki | 0.4500 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.3700 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 1.7000 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.6975 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.4500 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.4500 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 0.4500 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Ki | 0.4500 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.5600 | 4 | 5 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.4500 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Ki | 1.7500 | 3 | 4 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | IC50 | 16.6419 | 10 | 10 |
| Phosphodiesterase | Bos taurus (cattle) | IC50 | 1.0000 | 1 | 1 |
| Phosphodiesterase | Sus scrofa (pig) | IC50 | 0.8430 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 1.1845 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 4.7000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 0.1435 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 2.5180 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 1.0580 | 1 | 1 |
| signal transducer and activator of transcription 1-alpha/beta isoform alpha | Homo sapiens (human) | IC50 | 55.7000 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.1550 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.1230 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 0.3830 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.3800 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.8950 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.0060 | 1 | 1 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Canis lupus familiaris (dog) | IC50 | 0.5000 | 2 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (human) | IC50 | 1.7400 | 4 | 4 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 4.3000 | 1 | 1 |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (human) | Ki | 0.1077 | 1 | 4 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.1950 | 2 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens (human) | Ki | 0.1078 | 1 | 4 |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.1255 | 2 | 2 |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0039 | 2 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens (human) | Ki | 0.1077 | 1 | 4 |
| Sodium/potassium-transporting ATPase subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.9022 | 4 | 5 |
| Sodium/potassium-transporting ATPase subunit beta-2 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-3 | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Sodium/potassium-transporting ATPase subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0018 | 1 | 1 |
| Sodium/potassium-transporting ATPase subunit gamma | Homo sapiens (human) | IC50 | 2.2233 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 4.1700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 0.3085 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 3.2359 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 13.1826 | 1 | 1 |
| STAT3, partial | Homo sapiens (human) | IC50 | 1.5080 | 1 | 2 |
| Tissue factor | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 3.9750 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 5.5190 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | EC50 | 38.1152 | 2 | 2 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | EC50 | 0.0090 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | EC50 | 0.0375 | 3 | 3 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | EC50 | 0.0028 | 3 | 3 |
| Alpha-1B adrenergic receptor | Cricetulus griseus (Chinese hamster) | EC50 | 0.0100 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | EC50 | 0.0015 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC50 | 0.3060 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | EC50 | 0.3400 | 1 | 1 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | EC50 | 23.0167 | 6 | 6 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | EC50 | 23.0167 | 6 | 6 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | EC50 | 0.3565 | 22 | 23 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | EC50 | 0.9800 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0070 | 1 | 1 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0229 | 2 | 6 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0157 | 4 | 6 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | EC50 | 0.2670 | 27 | 28 |
| Beta-2 adrenergic receptor | Mus musculus (house mouse) | EC50 | 0.9800 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0070 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0251 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Kd | 0.2928 | 4 | 4 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Kd | 0.3300 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | EC50 | 0.3010 | 25 | 26 |
| Beta-3 adrenergic receptor | Mus musculus (house mouse) | EC50 | 0.9800 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0470 | 2 | 2 |
| Beta-adrenergic receptor kinase 1 | Homo sapiens (human) | Kd | 0.2000 | 1 | 1 |
| calcineurin A1, putative | Candida dubliniensis CD36 | EC50 | 180.0000 | 1 | 1 |
| Chain A, Na, K-ATPase alpha subunit | Squalus acanthias (spiny dogfish) | Kd | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| heat shock protein 90 | Candida albicans | EC50 | 120.0330 | 3 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0398 | 1 | 1 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 92.4917 | 2 | 3 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 1,108,477,796.2420 | 18 | 18 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | EC50 | 40.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.6500 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 1,936,025,008.0114 | 8 | 8 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 5,568,744,447.3554 | 9 | 9 |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | EC50 | 9.9000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.7027 | 21 | 21 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | EC50 | 9.6071 | 7 | 7 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | EC50 | 9,120,110,011.0422 | 10 | 10 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Nicotinamide phosphoribosyltransferase | Homo sapiens (human) | Kd | 230.0000 | 1 | 1 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 0.0390 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Kd | 0.1090 | 1 | 1 |
| Oxytocin receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 1 | 1 |
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Mus musculus (house mouse) | EC50 | 4.5000 | 1 | 1 |
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Mus musculus (house mouse) | EC50 | 4.5200 | 1 | 1 |
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Homo sapiens (human) | EC50 | 4.2800 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | EC50 | 19,952,600,000.0000 | 1 | 1 |
| Taste receptor type 2 member 1 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 10 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 13 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 14 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 16 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 19 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 20 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 3 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 30 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 31 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 39 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 4 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 40 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 41 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 42 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 43 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 45 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 46 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 5 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 50 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 60 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 7 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 8 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Taste receptor type 2 member 9 | Homo sapiens (human) | EC50 | 0.0049 | 1 | 1 |
| Vasopressin V1a receptor | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |