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dicarboxylic acids and O-substituted derivatives

A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens.

ChEBI ID: 131927

Members (6)

MemberDefinitionRole
3,4-di-O-acetyl-6-deoxy-L-glucal3,4-di-O-acetyl-6-deoxy-L-glucal
diethylhexyladipateA diester resulting from the formal condensation of the carboxy groups of adipic acid with 2-ethylhexan-1-ol. It is used as a plasticiser in the preparation of various polymers.bis(2-ethylhexyl) adipate
nemadipine-aA dihydropyridine that is that is 1,4-dihydropyridine which is substituted at positions 2 and 6 by methyl groups, at positions 3 and 5 by ethoxycarbonyl groups, and at position 4 by a pentafluorophenyl group. An L-type calcium channel alpha1-subunit antagonist. When exposed to the microscopic soil nematode Caenorhabditis elegans, nemadipine-A induces a variety of defects including those affecting morphology and egg laying.nemadipine-A
nimodipineA dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.nimodipine
nisoldipineA dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, a calcium channel blocker, is used in the treatment of hypertension and angina pectoris.methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
nitrendipineA dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.nitrendipine

Research

Studies (5,371)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19901,637 (30.48)18.7374
1990's2,094 (38.99)18.2507
2000's886 (16.50)29.6817
2010's583 (10.85)24.3611
2020's171 (3.18)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials863 (14.54%)5.53%
Reviews284 (4.79%)6.00%
Case Studies174 (2.93%)4.05%
Observational8 (0.13%)0.25%
Other4,606 (77.61%)84.16%