Compounds > tocotrienol, delta
Page last updated: 2024-12-10

tocotrienol, delta

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

delta-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5282350
CHEMBL ID121305
CHEBI ID33276
SCHEMBL ID8408117
SCHEMBL ID16430161
MeSH IDM0218857

Synonyms (48)

Synonym
BIDD:PXR0041
delta-tocotrienols
CHEBI:33276 ,
(2r)-2,8-dimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2h-chromen-6-ol
6-chromanol, 2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (7ci,8ci)
8-methyltocotrienol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2r)-
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2r)- (9ci)
(r)-delta-tocotrienol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [r-(e,e)]-
tocotrienol, delta
25612-59-3
delta-tocotrienol
CHEMBL121305
2r,8-dimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2h-chromen-6-ol
LMPR02020056
(2r)-2,8-dimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
unii-1srb74owsi
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (r-(e,e))-
1srb74owsi ,
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (2r)-
j17.358d ,
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-, (2r)-
delta tocotrienol [who-dd]
.delta.-tocotrienol
d-delta-tocotrienol
(r)-.delta.-tocotrienol
6-chromanol, 2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-
(r)-2,8-dimethyl-2-((3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,8-dimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-, (2r)-
SCHEMBL8408117
HMS3650C18
DTXSID30180288
SCHEMBL16430161
delta-tocotrienol, analytical standard
NCGC00253541-03
2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol
3,4-dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol, 9ci
Q27104272
SR-01000946270-1
sr-01000946270
(r-(e,e))-3,4-dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol
delta -tocotrienol
r-delta-tocotrienol
HY-122778
CS-0089253
AS-82630
AKOS040760094

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Neither drug produced detectable toxic effects in any other tissue at the doses tested."( Acute toxicity of subcutaneously administered vitamin E isomers delta- and gamma-tocotrienol in mice.
Chakraborty, K; Ghosh, SP; Lombardini, E; Pessu, RL; Swift, SN; Villa, V, )		0.13
" One patient had a drug-related adverse event (diarrhea) at a 3200-mg daily dose level."( A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia.
Centeno, B; Chen, DT; Husain, K; Hutchinson, TZ; Lush, RM; Malafa, MP; Neuger, A; Sebti, S; Springett, GM, 2015)		0.42
"No drug-related adverse events were observed."( Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites.
Chen, DT; Klapman, J; Mahipal, A; Malafa, MP; Neuger, A; Vignesh, S; Yang, CS, 2016)		0.43

Pharmacokinetics

ExcerptReferenceRelevance
" Pharmacokinetic data were derived from high-performance liquid chromatography (HPLC) assays."( Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites.
Chen, DT; Klapman, J; Mahipal, A; Malafa, MP; Neuger, A; Vignesh, S; Yang, CS, 2016)		0.43
" Pharmacokinetic parameters for single and multiple doses were, respectively, as follows (shown as range): time to maximum concentration of 4-9."( Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites.
Chen, DT; Klapman, J; Mahipal, A; Malafa, MP; Neuger, A; Vignesh, S; Yang, CS, 2016)		0.43

Bioavailability

ExcerptReferenceRelevance
"We have investigated the pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under fed and fasted conditions in eight healthy volunteers."( Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status.
Wong, JW; Yap, SP; Yuen, KH, 2001)		0.31
"A study was conducted to evaluate the bioavailability of alpha-, gamma- and delta-tocotrienols administered via oral, intravenous, intramuscular and intraperitoneal routes in rats."( Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats.
Lim, AB; Yap, SP; Yuen, KH, 2003)		0.32
"A single dose comparative bioavailability study was conducted to evaluate the bioavailability of tocotrienols from two self-emulsifying formulations, one of which produced an emulsion that readily lipolysed under in vitro condition (SES-A), while the other produced a finer dispersion with negligible lipolysis (SES-B) in comparison with that of a non-self-emulsifying formulation in soya oil."( Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations.
Yap, SP; Yuen, KH, 2004)		0.32
" This single-dose, randomized, crossover study aimed to compare the safety and bioavailability of a new formulation of Gamma Delta Tocotrienol (GDT) in comparison with the existing Tocotrienol-rich Fraction (TRF) in terms of gamma and delta isomers in healthy volunteers."( A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects.
Bhoo-Pathy, N; Chik, Z; Choudhury, RB; Fuang, HG; Jabir, RS; Meganathan, P; Nesaretnam, K; Taib, NA, 2015)		0.42
" Plasma tocotrienols were significantly increased after VEDT administration, indicating oral bioavailability of VEDT in humans."( Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites.
Chen, DT; Klapman, J; Mahipal, A; Malafa, MP; Neuger, A; Vignesh, S; Yang, CS, 2016)		0.43
" FA significantly increased the intracellular concentration of δ-T3, suggesting that FA improved the bioavailability of δ-T3, thereby increasing the inhibitory potency of δ-T3 on telomerase."( A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells.
Eitsuka, T; Miyazawa, T; Nakagawa, K; Nishida, H; Tatewaki, N, 2016)		0.43
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51

Dosage Studied

ExcerptRelevanceReference
" The tocotrienol-rich fraction (TRF) of palm oil inhibited growth of MCF7 cells in both the presence and absence of estradiol with a nonlinear dose-response but such that complete suppression of growth was achieved at 8 microg/mL."( Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status.
Darbre, P; Dils, R; Nesaretnam, K; Stephen, R, 1998)		0.3
" Tocotrienols were measured in heart, liver and adipose tissue showing that chronic oral dosage delivered tocotrienols to these organs despite low or no detection of tocotrienols in plasma."( Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats.
Brown, L; Fong, CW; Ward, LC; Wong, WY; Yap, WN, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (3 Product(s))

Product Categories

Product CategoryProducts
Professional Supplements1
Vitamins & Supplements2

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Dr. Mercola Vitamin E -- 30 CapsulesDr. MercolaProfessional Supplementsd-Beta Tocopherol, d-Alpha-Tocopherol, d-delta tocopherol, d-Gamma Tocopherol, d-Gamma Tocotrienol, Vitamin E, d-Alpha Tocotrienol, d-Beta Tocotrienol, d-Delta Tocotrienol2024-11-29 10:47:42
NutriCology Tocomin SupraBio Tocotrienols -- 200 mg - 60 SoftgelsNutriCologyVitamins & SupplementsVitamin E, d-Gamma Tocotrienol, Vitamin E, glycerin, d-Alpha Tocotrienol, d-Beta Tocotrienol, d-delta tocotrienol2024-11-29 10:47:42
Olympian Labs Tocomin Vitamin E Complete -- 60 SoftgelsOlympian LabsVitamins & Supplementsd-Beta Tocopherol, Vitamin E, d-delta tocopherol, d-Gamma Tocopherol, d-Gamma Tocotrienol, Vitamin E, Phytosterols, d-Alpha Tocotrienol, d-Beta Tocotrienol, d-delta tocotrienol2024-11-29 10:47:42

Roles (8)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
NF-kappaB inhibitorAn inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
apoptosis inducerAny substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Saccharomyces cerevisiae metaboliteAny fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
radiation protective agentAny compound that is able to protect normal cells from the damage caused by radiation therapy.
anti-inflammatory agentAny compound that has anti-inflammatory effects.
bone density conservation agentAn agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
tocotrienolA tocol in which the hydrocarbon chain at position 2 contains three double bonds.
vitamin EAny member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
vitamin E biosynthesis (tocotrienols)113

Bioassays (47)

Assay IDTitleYearJournalArticle
AID457739Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.
AID327671Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay2008Journal of natural products, Jan, Volume: 71, Issue:1
Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol.
AID1605744Agonist activity at LXR-beta (unknown origin) at 10 uM by coactivator recruitment based Alpha-screen assay2020Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
AID1662279Metabolic stability in mouse live microsomes assessed as compound degradation in absence of NADPH2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID194999Compound is evaluated for the inhibition of cholesterol biosynthesis in isolated rat hepatocytes at the concentration 250 (ug/mL)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID194996Inhibitory concentration required to inhibit cholesterol synthesis in isolated rat Hepatocytes1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID1662266Tmax in CD2F1 mouse at 200 mg/kg, sc measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID1662267Cmax in CD2F1 mouse at 200 mg/kg, sc measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID366535Antiproliferative activity against mouse +SA cells assessed as cell viability after 4 days by MTT assay2008Journal of natural products, Aug, Volume: 71, Issue:8
Sinulodurins A and B, antiproliferative and anti-invasive diterpenes from the soft coral Sinularia dura.
AID195000Compound is evaluated for the inhibition of cholesterol biosynthesis in isolated rat hepatocytes at the concentration 500 (ug/mL)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID1662265AUC (0 to last) in CD2F1 mouse at 50 mg/kg, iv measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID194998Compound is evaluated for the inhibition of cholesterol biosynthesis in isolated rat hepatocytes at the concentration 125 (ug/mL)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID690597Antioxidant activity assessed as ferric ion reducing power by FRAP method2011Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
AID1662269Intrinsic clearance in mouse liver microsomes2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID50641picomoles of mevalonic acid synthesized per minute per mg of microsomal protein1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID457738Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.
AID1612323Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by Alamar blue assay2019Journal of natural products, 03-22, Volume: 82, Issue:3
Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities.
AID51430Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for total cholesterol1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID1662268AUC (0 to last) in CD2F1 mouse at 200 mg/kg, sc measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID1662271Metabolic stability in mouse liver microsomes assessed as compound degradation at 1 uM preincubated for 30 mins followed by NADPH addition measured up to 30 mins by HPLC-UV analysis2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID1605741Agonist activity at His-tagged PXR-LBD/SRC-1p (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM by coactivator recruitment based Alpha-screen assay2020Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
AID1662273Volume of distribution in CD2F1 mouse at 50 mg/kg, iv measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID745932Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50632Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for HDL cholesterol1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID1662274Equlibrium constant in CD2F1 mouse at 50 mg/kg, iv measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID1662275AUC (0 to infinity) in CD2F1 mouse at 50 mg/kg, iv measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID537457Cytotoxicity against mouse +SA cells after 24 hrs by MTT assay2010Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.
AID1662277Induction of G-CSF production in CD2F1 mouse at 200 mg/kg, sc by G-CSF ELISA kit method2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID1662270Half life in mouse liver microsomes2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID86698Compound evaluated for Percent inhibition of cholesterol synthesis from HMG-CoA Reductase in HepG2 cell1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID1662272Clearance in CD2F1 mouse at 50 mg/kg, iv measured up to 24 hrs2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID1612324Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability incubated for 72 hrs by SYBR Green I dye based assay2019Journal of natural products, 03-22, Volume: 82, Issue:3
Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities.
AID1662278Induction of G-CSF production in CD2F1 mouse at 200 mg/kg, sc pretreated with ketoconazole after 24 hrs by G-CSF ELISA kit method2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID422002Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge2009Journal of natural products, Feb-27, Volume: 72, Issue:2
Benzophenone derivatives from the fruits of Garcinia multiflora and their anti-inflammatory activity.
AID422001Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge by spectrophotometry2009Journal of natural products, Feb-27, Volume: 72, Issue:2
Benzophenone derivatives from the fruits of Garcinia multiflora and their anti-inflammatory activity.
AID690612Antioxidant activity assessed as ABTS+ free radical scavenging activity by TEAC assay2011Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
AID1662276Plasma concentration in CD2F1 mouse at 200 mg/kg, sc administered as single dose measured after 1 hr by HPLC-fluorescence analysis2020Bioorganic & medicinal chemistry, 06-01, Volume: 28, Issue:11
Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
AID86699Compound evaluated for Percent inhibition of cholesterol synthesis from [14C]acetate in HepG2 cell1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID690600Antioxidant activity assessed as DPPH free radical scavenging activity2011Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
AID50653Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for LDL cholesterol1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID1605748Binding affinity to His-tagged PXR-LBD (unknown origin) expressed in Escherichia coli BL21 Gold at 60 uM by ITC analysis2020Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
AID277824Inhibition of alpha-glucosidase in 1.20 mg/200 uL2007Journal of natural products, Feb, Volume: 70, Issue:2
Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (158)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (5.70)18.2507
2000's26 (16.46)29.6817
2010's89 (56.33)24.3611
2020's34 (21.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.71 (24.57)
Research Supply Index5.16 (2.92)
Research Growth Index5.11 (4.65)
Search Engine Demand Index70.16 (26.88)
Search Engine Supply Index3.96 (0.95)

This Compound (28.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials12 (7.41%)5.53%
Reviews2 (1.23%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other148 (91.36%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0310alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.0610monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
phenol
[no description available]		2.2510phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.		2.610non-proteinogenic alpha-amino acid
diphenyleneiodonium
diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor. dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.		2.0510organic cation
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.		2.110aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
phenylmethylsulfonyl fluoride
Phenylmethylsulfonyl Fluoride: An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.. phenylmethanesulfonyl fluoride : An acyl fluoride with phenylmethanesulfonyl as the acyl group.		2.0510acyl fluorideserine proteinase inhibitor
potassium chloride
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.		2.1510inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		2.610L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
xanthone
xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.		2.0110xanthonesinsecticide
xanthenes
Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.		2.0110xanthene
scoparone
scoparone: structure. scoparone : A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.		2.0510aromatic ether;
coumarins		anti-allergic agent;
anti-inflammatory agent;
antihypertensive agent;
antilipemic drug;
immunosuppressive agent;
plant metabolite
hydantoins
Hydantoins: Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.. imidazolidine-2,4-dione : An imidazolidinone with oxo groups at position 2 and 4.		2.0510imidazolidine-2,4-dione
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.0810dialdehydebiomarker
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.110acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
deoxycytidine
[no description available]		3.6930pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		15.1614511alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
tocopherols
[no description available]		5.9270
fluorine
Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.		2.2510diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
1-deoxynojirimycin
1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.		2.03102-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid		anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
azoxymethane
Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.		2.3110
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.5320taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide
[no description available]		2.0710beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
ribavirin
Rebetron: Rebetron is tradename		2.03101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
1-methyl-4-phenylpyridinium
1-Methyl-4-phenylpyridinium: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.. N-methyl-4-phenylpyridinium : A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.		2.1310pyridinium ionapoptosis inducer;
herbicide;
human xenobiotic metabolite;
neurotoxin
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.110chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
lovastatin
Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.. lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).		340delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		3.6930organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
2-methoxyestradiol
2-methoxy-17beta-estradiol : A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.		2.171017beta-hydroxy steroid;
3-hydroxy steroid		angiogenesis modulating agent;
antimitotic;
antineoplastic agent;
human metabolite;
metabolite;
mouse metabolite
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.2110organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
tocophersolan
tocophersolan: RN given refers to parent cpd		2.0710tocol
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		2.0710diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
rosiglitazone
[no description available]		2.1310aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
delta-tocopherol
[no description available]		3.620tocopherol;
vitamin E		food antioxidant;
plant metabolite
gamma-tocopherol
gamma-Tocopherol: A natural tocopherol with less antioxidant activity than ALPHA-TOCOPHEROL. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. As in BETA-TOCOPHEROL, it also has three methyl groups on the 6-chromanol nucleus but at different sites.. gamma-tocopherol : A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.		5.0140tocopherol;
vitamin E		algal metabolite;
food antioxidant;
plant metabolite
annatto
annatto: coloring matter from seeds of Bixa orellana L., Bixaceae; contains bixin and pigments that give carotene reactions; induces hyperglycemia		8.3860
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.110cobalt group element atom;
metal allergen		micronutrient
2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman
2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman: natriuretic metabolite of gamma-tocopherol; structure in first source		2.0610benzopyranantioxidant
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		2.610secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
singlet oxygen
Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.		2.110chalcogen;
monoatomic oxygen;
nonmetal atom		macronutrient
wortmannin
[no description available]		2.110acetate ester;
cyclic ketone;
delta-lactone;
organic heteropentacyclic compound		anticoronaviral agent;
antineoplastic agent;
autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector;
Penicillium metabolite;
radiosensitizing agent
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		3.2503,5-dihydroxy-3-methylpentanoic acid
cinnamodial
cinnamodial: dialdehyde sesquiterpene; structure in first source		2.0310tertiary alcohol
ochratoxin a
ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.		2.1710isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.9911resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		1.9910octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.5220ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
t0901317
T0901317: an LXRalpha and LXRbeta agonist		3.1710
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		2.4720triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
4-hydroxyphenylmethylene hydantoin
4-hydroxyphenylmethylene hydantoin: isoalted from the Red Sea sponge Hemimycale arabica; structure in first source		2.0510
tamoxifen
[no description available]		2.9110stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
cobaltous chloride
cobaltous chloride: RN given refers to unlabeled cpd; RN in Chemline for cobalt trichloride: 10241-04-0; RN for 60-labeled cpd: 14543-09-0; RN for 57-labeled cpd: 164113-89-1; RN for 58-labeled cpd: 29377-09-1; structure. cobalt dichloride : A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.		2.110cobalt salt;
inorganic chloride		allergen;
calcium channel blocker;
sensitiser;
two-colour indicator
6,7,8-trimethoxycoumarin
6,7,8-trimethoxycoumarin: structure in first source		2.0510coumarins
quercetin
[no description available]		2.78307-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0810prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
geranylgeraniol
(E,E,E)-geranylgeraniol : A geranylgeraniol in which all four double bonds have E- (trans-) geometry.		2.0610geranylgeraniol
tocotrienol, alpha
alpha-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.		8.55331tocotrienol;
vitamin E		ferroptosis inhibitor;
human metabolite;
neuroprotective agent;
plant metabolite
tocotrienol, beta
beta-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5 and 8 and a farnesyl chain at position 2. It has been isolated from various cultivars of wheat.		5.0190tocotrienol;
vitamin E		antineoplastic agent;
apoptosis inducer;
plant metabolite
gamma-tocotrienol
gamma-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers.		4.0550tocotrienol;
vitamin E		antineoplastic agent;
antioxidant;
apoptosis inducer;
hepatoprotective agent;
plant metabolite;
radiation protective agent
cytochalasin b
Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.		2.110cytochalasin;
lactam;
lactone;
organic heterotricyclic compound		actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor
triolein
Triolein: (Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.. triolein : A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.		1.9910triglycerideCaenorhabditis elegans metabolite;
plant metabolite
mevalonolactone
mevalonolactone: RN given refers to unlabeled cpd without isomeric designation; structure. mevalonolactone : A racemate comprising equimolar amounts of (R)-mevalonolactone and (S)-mevalonolactone.		2.06104-hydroxy-4-methyloxan-2-onefungal metabolite;
plant metabolite
plastochromanol 8
plastochromanol 8: has antiproliferative activity against 3T3-L1 cells and anti-adipogenic activity; structure; plastochromanol 3 is gamma-tocotrienol		11.39442
beta-escin
[no description available]		210
beta-sitosterone
beta-sitosterone: from Torreya jackii		2.0510
tocotrienols
tocotrienol : A tocol in which the hydrocarbon chain at position 2 contains three double bonds.		9.45402diterpenoid
vismione b
vismione B: from Cratoxylum sumatranum; structure in first source		2.0110
trans-delta-tocotrienoloic acid
tocotrienoloic acid: from leaves of Tovomitopsis psychotriifolia; structure given in first source		3.1710tocotrienol
cembra-2,7,11-triene-4,6-diol
cembra-2,7,11-triene-4,6-diol: isolated from tobacco; structure in first source. cembra-2,7,11-triene-4,6-diol : A cembrane diterpenoid obtained from tobacco and shown to have antitumour-promoting activity.		2.0410cembrane diterpenoidantineoplastic agent
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.4920
hes1 protein, human
HES1 protein, human: RefSeq NM_005524		2.0710
plx4032
[no description available]		2.1710aromatic ketone;
difluorobenzene;
monochlorobenzenes;
pyrrolopyridine;
sulfonamide		antineoplastic agent;
B-Raf inhibitor
alpha-tocomonoenol
alpha-tocomonoenol: isolated from the Pacific salmon, Oncorhynchus keta; structure in first source		2.1510
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.110ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		2.4120
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.		340
bixin
bixin: structure. bixin : A carotenoic acid that is the 6'-monomethyl ester of 9'-cis-6,6'-diapocarotene-6,6'-dioic acid.		2.3110
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.03102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
cyclic gmp
Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.		2.06103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
quillaja saponins
Quillaja Saponins: Natural detergents made up of a heterogeneous mixture of molecules having a triterpenoid core structure. They vary in aglycone (sapogenin) and sugar moieties, including glucose.		2.1710
garcinoic acid
[no description available]		2.5120
ConditionIndicatedRelationship StrengthStudiesTrials
Invasiveness, Neoplasm
[description not available]		02.7530
Breast Cancer
[description not available]		07.36111
Breast Neoplasms
Tumors or cancer of the human BREAST.		07.36111
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.3760
Congenital Zika Syndrome
[description not available]		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Cancer of Ovary
[description not available]		02.3110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.3110
Hepatocellular Carcinoma
[description not available]		05.470
Cancer of Liver
[description not available]		05.470
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		05.470
Liver Neoplasms
Tumors or cancer of the LIVER.		05.470
Prediabetes
[description not available]		03.811
Prediabetic State
The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).		03.811
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.4110
Cancer of Prostate
[description not available]		03.85100
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		03.85100
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		04.7461
Fatty Liver, Nonalcoholic
[description not available]		06.8254
Innate Inflammatory Response
[description not available]		07.5763
Insulin Sensitivity
[description not available]		04.9132
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.5763
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.		04.9132
Non-alcoholic Fatty Liver Disease
Fatty liver finding without excessive ALCOHOL CONSUMPTION.		06.8254
Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)		07.4110
Cardiometabolic Syndrome
A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY.		04.0421
Metabolic Syndrome
A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.		04.0421
Adverse Drug Event
[description not available]		03.9911
Drug-Related Side Effects and Adverse Reactions
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.		03.9911
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		03.5320
Cancer of Colon
[description not available]		03.9440
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		02.3110
Colonic Neoplasms
Tumors or cancer of the COLON.		03.9440
Malignant Melanoma
[description not available]		03.140
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		03.140
Diabetes Mellitus, Adult-Onset
[description not available]		03.711
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		03.711
Angiogenesis, Pathologic
[description not available]		04.3940
Edema-Proteinuria-Hypertension Gestosis
[description not available]		02.3110
Pre-Eclampsia
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.		02.3110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.4720
Metastase
[description not available]		02.1510
Cancer of Pancreas
[description not available]		08.75114
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.1510
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		08.75114
Cold Panniculitis
[description not available]		02.1510
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).		03.4620
Benign Neoplasms
[description not available]		03.4420
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.4420
Androgen-Independent Prostatic Cancer
[description not available]		02.5820
Prostatic Neoplasms, Castration-Resistant
Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.		02.5820
Anoxemia
[description not available]		02.1710
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		02.1710
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
[description not available]		02.1710
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.		02.1710
Liver Steatosis
[description not available]		04.8721
Fatty Liver
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.		04.8721
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.		02.1710
Chronic Hepatitis C
[description not available]		02.1710
Hepatitis C, Chronic
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.		02.1710
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.2110
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.2110
Colorectal Cancer
[description not available]		04.5650
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		04.5650
Experimental Radiation Injuries
[description not available]		02.0810
B16 Melanoma
[description not available]		03.940
Adenocarcinoma, Basal Cell
[description not available]		03.9240
Animal Mammary Carcinoma
[description not available]		02.520
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		03.9240
Adjuvant Arthritis
[description not available]		02.110
Lung Adenocarcinoma
[description not available]		02.110
Astrocytoma, Grade IV
[description not available]		02.110
Cancer of Lung
[description not available]		02.7730
Central Nervous System Neoplasm
[description not available]		02.110
Adenocarcinoma of Lung
A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.		02.110
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		02.110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.7730
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.		02.110
Age-Related Osteoporosis
[description not available]		02.1110
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.1110
Injuries, Radiation
[description not available]		02.1110
Bladder Cancer
[description not available]		02.1110
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		02.1110
Abdominal Obesity
[description not available]		02.1510
Idiopathic Parkinson Disease
[description not available]		02.1310
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)		02.1310
Carcinoma, Ductal, Pancreatic
[description not available]		07.7154
Carcinoma, Pancreatic Ductal
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.		07.7154
Benign Neoplasms, Brain
[description not available]		02.1310
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.1310
Dysplastic Nevus Syndrome, Hereditary
[description not available]		02.1310
Cancer of Skin
[description not available]		02.1310
Skin Neoplasms
Tumors or cancer of the SKIN.		02.1310
Experimental Hepatoma
[description not available]		02.0510
Atherogenesis
[description not available]		02.0510
Atherosclerosis
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.		02.0510
Left Ventricular Dysfunction
[description not available]		02.0610
Cardiac Remodeling, Ventricular
[description not available]		02.0610
Cirrhosis
[description not available]		02.0610
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.		02.0610
Ventricular Dysfunction, Left
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.		02.0610
Carcinoma, Non-Small Cell Lung
[description not available]		03.6830
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		03.6830
Carcinoma, Anaplastic
[description not available]		02.9810
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.9810
Weight Gain
Increase in BODY WEIGHT over existing weight.		02.0610
Bone Loss, Osteoclastic
[description not available]		02.0610
Pancytopenia
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.		02.0710
Disease Exacerbation
[description not available]		02.0810
Carcinoma, Intraepithelial
[description not available]		02.0810
Carcinoma in Situ
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.		02.0810
Arteriosclerosis
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.		02.4120
Dominant Hereditary Sensory Neuropathy, Type III
[description not available]		02.0110
Dysautonomia, Familial
An autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent. Clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension (HYPOTENSION, ORTHOSTATIC), fixed pupils, excessive SWEATING, loss of pain and temperature sensation, and absent reflexes. Pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons. (From Adams et al., Principles of Neurology, 6th ed, p1348; Nat Genet 1993;4(2):160-4)		02.0110
Elevated Cholesterol
[description not available]		02.9410
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.		02.9410
Hormone-Dependent Neoplasms
[description not available]		02.9110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		0210
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0110