Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma.
| Member | Definition | Class |
|---|
| amoscanate | An isothiocyanate that is phenyl isothiocyanate in which the hydrogen at the para- position has been replaced by a 4-nitroanilinyl group. | amoscanate |
| hycanthone | A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. | hycanthone |
| hycanthone methanesulfonate | A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. | hycanthone mesylate |
| lucanthone | A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. | lucanthone |
| oltipraz | A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively. | oltipraz |
| trans-phytol | A diterpenoid that is hexadec-2-en-1-ol substituted by methyl groups at positions 3, 7, 11 and 15. | phytol |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 11.9048 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 30.9008 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 19.4912 | 8 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 0.8596 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.4921 | 1 | 1 |
| BRCA1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 8.1230 | 2 | 2 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 21.7515 | 2 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.3649 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 11.2947 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 2.6603 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 40.3592 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.5107 | 7 | 7 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 27.3116 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 10.7603 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 32.0887 | 1 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 26.6011 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 32.7153 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 11.2947 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 22.5046 | 2 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.3862 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 28.9342 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 18.8560 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 10.5784 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 8.0581 | 3 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 11.5821 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 25.5518 | 2 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.6146 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 6.6819 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 7.5624 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 3.2351 | 3 | 4 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.4127 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 23.7083 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 2.8184 | 1 | 1 |
| polyprotein | Zika virus | Potency | 25.1189 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 26.2123 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.8832 | 1 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.1317 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.9630 | 2 | 2 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 13.6788 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.6511 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 2.0499 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 13.3332 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 2.8184 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 2.8184 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 5.3080 | 1 | 1 |