Roles > schistosomicide drug
Page last updated: 2024-08-05 15:21:51

schistosomicide drug

Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma.

ChEBI ID: 38941

Members (6)

MemberDefinitionClass
amoscanateAn isothiocyanate that is phenyl isothiocyanate in which the hydrogen at the para- position has been replaced by a 4-nitroanilinyl group.amoscanate
hycanthoneA thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.hycanthone
hycanthone methanesulfonateA methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.hycanthone mesylate
lucanthoneA thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.lucanthone
oltiprazA 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.oltipraz
trans-phytolA diterpenoid that is hexadec-2-en-1-ol substituted by methyl groups at positions 3, 7, 11 and 15.phytol

Research

Studies (915)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990535 (58.47)18.7374
1990's141 (15.41)18.2507
2000's142 (15.52)29.6817
2010's73 (7.98)24.3611
2020's24 (2.62)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials51 (4.98%)5.53%
Reviews69 (6.74%)6.00%
Case Studies17 (1.66%)4.05%
Observational0 (0.00%)0.25%
Other887 (86.62%)84.16%

Protein Targets (98)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency11.904812
acetylcholinesteraseHomo sapiens (human)Potency30.900811
AR proteinHomo sapiens (human)Potency19.491288
aryl hydrocarbon receptorHomo sapiens (human)Potency0.859622
ATAD5 protein, partialHomo sapiens (human)Potency20.596211
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency8.492111
BRCA1Homo sapiens (human)Potency35.481311
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.118711
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency13.333211
caspase-3Homo sapiens (human)Potency13.333211
Cellular tumor antigen p53Homo sapiens (human)Potency8.123022
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency12.589311
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency56.234111
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency21.751523
cytochrome P450 2D6Homo sapiens (human)Potency4.364911
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency5.011911
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency11.294724
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency2.660311
DNA polymerase betaHomo sapiens (human)Potency15.848911
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency19.952611
DNA polymerase kappa isoform 1Homo sapiens (human)Potency40.359213
estrogen nuclear receptor alphaHomo sapiens (human)Potency20.510777
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency27.311622
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency10.760366
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency32.088712
farnesoid X nuclear receptorHomo sapiens (human)Potency26.601111
flap endonuclease 1Homo sapiens (human)Potency32.715322
Fumarate hydrataseHomo sapiens (human)Potency25.118911
GABA theta subunitRattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency11.294712
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency11.294712
gemininHomo sapiens (human)Potency22.504624
GLI family zinc finger 3Homo sapiens (human)Potency11.386222
glp-1 receptor, partialHomo sapiens (human)Potency11.220211
GLS proteinHomo sapiens (human)Potency28.934212
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency18.856033
Glutamate receptor 1Rattus norvegicus (Norway rat)Potency15.848911
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency10.578422
Glutamate receptor 3Rattus norvegicus (Norway rat)Potency15.848911
Glutamate receptor 4Rattus norvegicus (Norway rat)Potency15.848911
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency31.622811
huntingtin isoform 2Homo sapiens (human)Potency8.058133
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency5.011922
IDH1Homo sapiens (human)Potency11.582111
Interferon betaHomo sapiens (human)Potency25.551824
lamin isoform A-delta10Homo sapiens (human)Potency5.614612
Microtubule-associated protein tauHomo sapiens (human)Potency28.370812
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency17.782811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency6.681922
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency6.513111
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency7.562411
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency3.235134
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency6.412722
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency33.488911
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency23.708311
plasminogen precursorMus musculus (house mouse)Potency2.818411
polyproteinZika virusPotency25.118911
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency28.183811
PPM1D proteinHomo sapiens (human)Potency26.212312
pregnane X nuclear receptorHomo sapiens (human)Potency26.603211
progesterone receptorHomo sapiens (human)Potency33.491511
RAR-related orphan receptor gammaMus musculus (house mouse)Potency11.883212
ras-related protein Rab-9AHomo sapiens (human)Potency3.981111
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency21.131722
retinoid X nuclear receptor alphaHomo sapiens (human)Potency17.963022
signal transducer and activator of transcription 6, interleukin-4 inducedHomo sapiens (human)Potency31.622822
Smad3Homo sapiens (human)Potency35.481311
survival motor neuron protein isoform dHomo sapiens (human)Potency13.678812
TDP1 proteinHomo sapiens (human)Potency0.651124
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency2.049933
thyroid stimulating hormone receptorHomo sapiens (human)Potency13.333211
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency2.818411
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency2.818411
USP1 protein, partialHomo sapiens (human)Potency0.223911
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency5.308011

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bile salt export pumpHomo sapiens (human)IC5029.800011
Cytochrome P450 1A2Homo sapiens (human)Ki9.000011
Cytochrome P450 2D6Homo sapiens (human)IC501.500011
DNA-(apurinic or apyrimidinic site) endonucleaseHomo sapiens (human)IC503.360023
Replicase polyprotein 1abBetacoronavirus England 1IC5010.000012
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC500.415012
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC5032.600011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
DNA-(apurinic or apyrimidinic site) endonucleaseHomo sapiens (human)Kd0.049512

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
DNA repair and recombination protein RAD54-like isoform 1Homo sapiens (human)AC506.950011
DNA repair protein RAD52 homolog isoform aHomo sapiens (human)AC509.330011
Nuclear factor erythroid 2-related factor 2Mus musculus (house mouse)CD10.200011
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