Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
| Member | Definition | Class |
|---|
| (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone | A organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group. | WIN 55212-2 |
| (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | A stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. | (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside |
| 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole | A mmeber of the class of imidazolines and organic radical that is 4,4,5,5-tetramethyl-3-oxo-4,5-dihydro-1H-3lambda(5)-imidazol-1-yl]oxidanyl substituted at position 2 by a 4-carboxyphenyl group. | carboxy-PTIO |
| 2,5-dihydroxybenzyl alcohol | An aromatic primary alcohol that is benzyl alcohol substituted by hydroxy groups at positions 2 and 5. | gentisyl alcohol |
| abyssinone i | A monohydroxyflavanone that is (2S)-2',2'-dimethyl-2,3-dihydro-2'H,4H-2,6'-bichromen-4-one carrying a hydroxy substituent at position 7. | abyssinone I |
| aspartame | A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener. | aspartame zwitterion; aspartame |
| beauvericin | A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues. | beauvericin |
| bis(7)-tacrine | A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. | bis(7)-tacrine |
| bongkrekic acid | A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group. It is produced by the bacterium Burkholderia gladioli and implicated in outbreaks of food-borne illness involving coconut and corn-based products in Indonesia and China. | bongkrekic acid |
| carbobenzoxyvalylphenylalanine aldehyde | A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpain I and II, and is also a gamma-secretase inhibitor. | Z-Val-Phe-H |
| diethylhexyl phthalate | A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid. | bis(2-ethylhexyl) phthalate |
| ferulic acid | A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring. | ferulic acid |
| fostriecin | A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines. | fostriecin |
| fraxetin | A hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. | fraxetin |
| genipin | | Genipin |
| ginsenoside f1 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | ginsenoside F1 |
| ginsenoside rb1 | A ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. | ginsenoside Rb1 |
| hu 308 | A carbobicyclic compound that is bicyclo[3.1.1]hept-2-ene which is substituted by a hydroxymethyl group at position 2, a 2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl group at position 4, and two methyl groups at position 6 (the 1S,4S,5S stereoisomer). A highly selective and effective cannabinoid type-2 agonist and the enantiomer of HU-433. | HU-308 |
| jwh-133 | A dibenzopyran that is Delta(9)-tetrahydrocannabinol which is lacking the hydroxy group and in which the pentyl group at position 3 has been replaced by a 1,1-dimethylbutyl group. A potent and highly selective CB2 receptor agonist. | JWH-133 |
| molsidomine | A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure. | 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate; molsidomine |
| molsidomine | A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure. | 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate; molsidomine |
| naphthalene | An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia. | naphthalene |
| p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe | A thirteen-membered polypeptide consisting of p-Glu, Arg, Pro, Arg, Leu, Ser, His, Lys, Gly, Pro, Met, Pro and Phe residues joined in sequence. | p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe |
| pd 150606 | An organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer). | (Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid |
| protectin d1 | A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1 | protectin D1 |
| salvigenin | A trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4', 6, and 7 are replaced by methoxy groups. | salvigenin |
| schizandrin b | An organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis. | (+)-schisandrin B; Deoxygomisin A |
| suramin | A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. | suramin |
| suramin sodium | An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. | suramin sodium |
| tepoxalin | A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs. | tepoxalin |
| tetramethylpyrazine | A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii). | tetramethylpyrazine |
| triacsin c | A nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters. | triacsin C |
| ursodoxicoltaurine | A bile acid taurine conjugate derived from ursoodeoxycholic acid. | tauroursodeoxycholic acid |
| z-val-ala-asp(ome)-fluoromethylketone | A tripeptide consisting of Z-Val-Ala-Asp(OMe) in which the C-terminal OH group has been replaced by a fluoromethyl group. An irreversible pan-caspase inhibitor. | Z-Val-Ala-Asp(OMe)-CH2F |
| zofenopril | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-3-(benzoylsulfanyl)-2-methylpropanoyl group. A prodrug for zofenoprilat. | zofenopril |
| zofenoprilate | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-2-methyl-3-sulfanylpropanoyl group. The active metabolite of zofenopril. | zofenoprilat |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 20.4839 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 5.0119 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 4.2527 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 21.6076 | 1 | 5 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 3.5481 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 33.7163 | 7 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 26.1171 | 2 | 3 |
| arylsulfatase A | Homo sapiens (human) | Potency | 13.3870 | 1 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 27.8646 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 7.0795 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.2523 | 2 | 5 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 29.0941 | 1 | 3 |
| Caspase-7 | Homo sapiens (human) | Potency | 17.9008 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 13.6854 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.4629 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.5870 | 3 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.5991 | 2 | 2 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 8.9662 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 7.9870 | 2 | 6 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 48.5178 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 12.1917 | 3 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.4824 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 6.5708 | 2 | 8 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 7.9870 | 2 | 6 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 63.0437 | 2 | 3 |
| ClpP | Bacillus subtilis | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.2916 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.8975 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 7.5921 | 2 | 7 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 3.7112 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 32.6705 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.0595 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 18.4927 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 0.2528 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.7656 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 13.6387 | 1 | 5 |
| endonuclease IV | Escherichia coli | Potency | 9.5307 | 2 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 23.5640 | 6 | 8 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 20.7033 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 21.3982 | 8 | 10 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 21.4047 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 25.5440 | 4 | 10 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 17.8373 | 3 | 5 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 8.6746 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 26.5350 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 10.2916 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| galactokinase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 7.4318 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 2.9556 | 3 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 27.2973 | 3 | 6 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 10.5006 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.0990 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.1645 | 1 | 1 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 17.7578 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 9.2683 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 23.7083 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 25.1392 | 2 | 8 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 55.1965 | 2 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 22.2457 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.2916 | 1 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 33.0488 | 3 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 22.6142 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 6.4528 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 38.1456 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.2916 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.9205 | 2 | 5 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 10.2916 | 1 | 2 |
| interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.7586 | 2 | 5 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 19.7830 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.5362 | 2 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 32.5733 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 20.8108 | 2 | 9 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 3.1808 | 2 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.0665 | 2 | 4 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 46.2250 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 6.7052 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 19.9526 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 21.7305 | 3 | 7 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 6.6896 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 36.1254 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 10.6910 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 27.6971 | 2 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 39.3247 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 59.5034 | 1 | 4 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| Platelet-activating factor receptor | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| polyprotein | Zika virus | Potency | 26.5350 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.6502 | 2 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 40.4624 | 2 | 5 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 0.7943 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 6.0887 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0075 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.5931 | 2 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.3325 | 2 | 7 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 16.5545 | 3 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 21.8751 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 21.8751 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 38.1456 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 11.2202 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.6728 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.8849 | 2 | 6 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 36.2212 | 3 | 8 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.3365 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.6071 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 3.9292 | 3 | 5 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 32.0887 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 25.3735 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 12.2776 | 4 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 65.1337 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 26.6032 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 50.0003 | 6 | 6 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 11.1120 | 9 | 9 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 0.0019 | 1 | 1 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 0.0158 | 12 | 14 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 0.0016 | 2 | 4 |
| Acetylcholinesterase | Bos taurus (cattle) | Ki | 0.0013 | 4 | 4 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 9.9033 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 8.4200 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 251.4000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 0.7500 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 111.5433 | 2 | 3 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | IC50 | 0.0080 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 0.0004 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 0.0004 | 1 | 1 |
| Apelin receptor | Homo sapiens (human) | IC50 | 0.0012 | 1 | 1 |
| Apelin receptor | Homo sapiens (human) | Ki | 0.0007 | 5 | 5 |
| Apelin receptor | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 2.9000 | 1 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei | IC50 | 3.0000 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 3.6633 | 1 | 3 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 7.5000 | 3 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 711.0000 | 2 | 3 |
| Calpain-1 catalytic subunit | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Calpain-1 catalytic subunit | Sus scrofa (pig) | IC50 | 18.5500 | 2 | 2 |
| Calpain-1 catalytic subunit | Homo sapiens (human) | Ki | 0.0080 | 1 | 1 |
| Calpain-1 catalytic subunit | Sus scrofa (pig) | Ki | 0.0100 | 1 | 1 |
| Calpain-9 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 0.0710 | 7 | 7 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 0.2472 | 77 | 84 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | Ki | 0.0186 | 4 | 4 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 91,203.2399 | 10 | 10 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | Ki | 0.0060 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 0.0189 | 6 | 6 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.0057 | 81 | 93 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 156.4375 | 3 | 4 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.0867 | 3 | 3 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 9.7300 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 12.2000 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 9.4300 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 6.4400 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 178.6750 | 3 | 4 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 3.6633 | 1 | 3 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 11.1000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 10.8000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 8.8600 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7.0400 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 5.8650 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 9.3900 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 5.2400 | 2 | 2 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 0.0100 | 1 | 1 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 0.1675 | 5 | 5 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 0.0020 | 3 | 3 |
| Cathepsin B | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | Ki | 0.0240 | 1 | 1 |
| Chain A, Cytosol aminopeptidase | Bos taurus (cattle) | Ki | 0.8000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 25.0038 | 4 | 4 |
| Cholinesterase | Homo sapiens (human) | IC50 | 16.6785 | 5 | 6 |
| Cholinesterase | Mus musculus (house mouse) | IC50 | 0.0091 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | Ki | 0.0020 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| Chymotrypsinogen A | Bos taurus (cattle) | Ki | 54.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 700.0000 | 1 | 1 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 73.9802 | 2 | 2 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 25.0018 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0053 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0020 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.0053 | 1 | 2 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 18.1000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 26.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 405.7535 | 1 | 2 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 8.2000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| Dual specificity protein phosphatase 5 | Homo sapiens (human) | Ki | 0.0250 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 2 | 2 |
| Ectonucleoside triphosphate diphosphohydrolase 2 | Rattus norvegicus (Norway rat) | Ki | 65.4000 | 2 | 2 |
| Ectonucleoside triphosphate diphosphohydrolase 3 | Rattus norvegicus (Norway rat) | Ki | 12.7000 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 8 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 24.6739 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 0.0730 | 1 | 1 |
| Hyaluronidase-1 | Homo sapiens (human) | IC50 | 2,000.0000 | 1 | 1 |
| Ileal sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 28.0000 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | IC50 | 32.1000 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | Ki | 5.5100 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 250.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | Ki | 0.0019 | 1 | 1 |
| NAD-dependent protein deacetylase HST2 | Saccharomyces cerevisiae S288C | IC50 | 240.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | IC50 | 1.3857 | 7 | 7 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 1.1750 | 4 | 4 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 20.6000 | 8 | 8 |
| Nitric oxide synthase, endothelial | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | IC50 | 21.9054 | 1 | 2 |
| P2Y purinoceptor 11 | Homo sapiens (human) | Ki | 0.2071 | 2 | 2 |
| P2Y purinoceptor 2 | Homo sapiens (human) | IC50 | 75.0000 | 2 | 2 |
| P2Y purinoceptor 6 | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 350.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 0.6667 | 3 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 3.9750 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 524.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 2.8500 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 3.5250 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 2.8500 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 3.5250 | 2 | 2 |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | IC50 | 344.8100 | 3 | 3 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 0.4733 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 20.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 12.2000 | 2 | 2 |
| RmtA | Aspergillus nidulans | IC50 | 5.9000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| Signal transducer and activator of transcription 3 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Signal transducer and activator of transcription 5A | Homo sapiens (human) | IC50 | 9.4000 | 1 | 1 |
| Signal transducer and activator of transcription 5B | Homo sapiens (human) | IC50 | 10.4000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 200.0000 | 3 | 3 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 200.0000 | 3 | 3 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 200.0000 | 3 | 3 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 2,800.0000 | 3 | 3 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 186.5867 | 3 | 3 |
| Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 2 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 8.2000 | 1 | 1 |