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parasympatholytic
Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists.
ChEBI ID: 50370
Members (13)
| Member | Definition | Class |
|---|---|---|
| biperiden | A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease. | biperiden |
| biperiden hydrochloride | The hydrochloride salt of biperiden. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease. | biperiden hydrochloride |
| cyclopentolate | A carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its hydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action. | cyclopentolate |
| dicyclomine | The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome. | dicyclomine |
| diphemanil methylsulfate | The alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating). | diphemanil methylsulfate |
| flavoxate | A carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol. | flavoxate |
| flavoxate hydrochloride | The hydrochloride salt of flavoxate. | flavoxate hydrochloride |
| glycerylphosphorylcholine | A member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. | choline alfoscerate |
| octotropine methylbromide | A quaternary ammonium salt resulting from the reaction of the amino group of anisotropine with methyl bromide. | anisotropine methylbromide |
| orphenadrine | A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol. | orphenadrine |
| orphenadrine citrate | A citrate salt which comprises equimolar amounts of orphenadrine and citric acid. | orphenadrine citrate |
| orphenadrine hydrochloride | A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride. | orphenadrine hydrochloride |
| oxybutynin | A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder. | 4-(diethylamino)but-2-yn-1-ol; oxybutynin |
Research
Studies (4,383)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,025 (23.39) | 18.7374 |
| 1990's | 525 (11.98) | 18.2507 |
| 2000's | 704 (16.06) | 29.6817 |
| 2010's | 1,709 (38.99) | 24.3611 |
| 2020's | 420 (9.58) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 918 (18.94%) | 5.53% |
| Reviews | 435 (8.97%) | 6.00% |
| Case Studies | 531 (10.95%) | 4.05% |
| Observational | 51 (1.05%) | 0.25% |
| Other | 2,913 (60.09%) | 84.16% |
Protein Targets (150)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 27.3430 | 3 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 18.9966 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 8.1961 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 28.7968 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 6.7456 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 158.4890 | 2 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 29.8493 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 29.8493 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 17.3212 | 1 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.4839 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 2.7576 | 1 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 61.0200 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.5294 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 5.6934 | 1 | 6 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 6.9662 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 5.8413 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.9625 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 15.5619 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 8.6420 | 3 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 8.0662 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 26.5834 | 4 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.3963 | 1 | 6 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 9.1231 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 6.5294 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 5.8413 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 18.4362 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 19.1287 | 2 | 11 |
| GLS protein | Homo sapiens (human) | Potency | 15.0654 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 55.3055 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 18.1401 | 2 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 49.1940 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.5294 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.5294 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 11.5319 | 3 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 1.9210 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 10.1815 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0738 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.0200 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 33.9326 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 23.0470 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0022 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 95.2834 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 58.2929 | 1 | 2 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 25.7877 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 10.5906 | 1 | 4 |
| PPM1D protein | Homo sapiens (human) | Potency | 11.7086 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 20.3089 | 3 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.9303 | 2 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 35.4401 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 22.6365 | 1 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 25.3735 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 25.3735 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.3174 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.2797 | 2 | 11 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.9497 | 1 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.8040 | 2 | 14 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 30.2894 | 5 | 8 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 24.2442 | 2 | 10 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.3380 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0970 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.8280 | 1 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.1633 | 1 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5010 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2625 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5010 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.2625 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 2.0930 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.9720 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 12.6000 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.6306 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.6083 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 2.1560 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.8090 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.8950 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.8650 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Ki | 0.0059 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 22.3489 | 1 | 2 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 18.3100 | 1 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 224.4480 | 4 | 5 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.8194 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.2783 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 49.4823 | 2 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.1440 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 4.2930 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 4.2215 | 1 | 2 |
| Lethal(3)malignant brain tumor-like protein 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 3 | Homo sapiens (human) | IC50 | 54.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| MBT domain-containing protein 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0517 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0072 | 4 | 6 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0059 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.1497 | 1 | 3 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0299 | 5 | 7 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0105 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.0607 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0069 | 5 | 7 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 2 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.0433 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0107 | 3 | 5 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.0112 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0095 | 2 | 4 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 22.3489 | 1 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 18.3100 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 15.1830 | 2 | 3 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 18.3100 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.0145 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0061 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.0855 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.0679 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.6306 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.6083 | 1 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.4580 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.2430 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 56.3000 | 2 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0794 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Kd | 0.0398 | 1 | 1 |
| ORF73 | Human gammaherpesvirus 8 | EC50 | 75.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Kb | 0.0100 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Kb | 0.0980 | 1 | 4 |