A dicarboximide that is phthalimide or derivatives obtained from it by the formal replacement of one or more hydrogens.
| Member | Definition | Role |
|---|
| (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid | | (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid |
| 1-butyl-2-[(1,3-dioxo-2-isoindolyl)methylthio]-5-benzimidazolesulfonamide | | 1-butyl-2-[(1,3-dioxo-2-isoindolyl)methylthio]-5-benzimidazolesulfonamide |
| 1H-indazole-3-carboxylic acid 4-(1,3-dioxo-2-isoindolyl)butyl ester | | 1H-indazole-3-carboxylic acid 4-(1,3-dioxo-2-isoindolyl)butyl ester |
| 2-(1-ethoxycarbonyl-4-piperidinyl)-1,3-dioxo-5-isoindolecarboxylic acid | | 2-(1-ethoxycarbonyl-4-piperidinyl)-1,3-dioxo-5-isoindolecarboxylic acid |
| 2-(1,3-benzodioxol-5-ylmethyl)isoindole-1,3-dione | | 2-(1,3-benzodioxol-5-ylmethyl)isoindole-1,3-dione |
| 2-(1,3-dimethyl-1H-pyrazol-5-yl)-1H-isoindole-1,3(2H)-dione | | 2-(1,3-dimethyl-1H-pyrazol-5-yl)-1H-isoindole-1,3(2H)-dione |
| 2-(1,3-dioxo-2-isoindolyl)-N-(3-nitrophenyl)acetamide | | 2-(1,3-dioxo-2-isoindolyl)-N-(3-nitrophenyl)acetamide |
| 2-(1,3-dioxo-2-isoindolyl)-N-(4-methyl-1,3-benzothiazol-2-yl)acetamide | | 2-(1,3-dioxo-2-isoindolyl)-N-(4-methyl-1,3-benzothiazol-2-yl)acetamide |
| 2-(3-chloro-4-methylphenyl)isoindole-1,3-dione | | 2-(3-chloro-4-methylphenyl)isoindole-1,3-dione |
| 2-(4-nitro-2-pyridinyl)isoindole-1,3-dione | | 2-(4-nitro-2-pyridinyl)isoindole-1,3-dione |
| 2-[(1R)-1-carboxy-2-(1-naphthalenyl)ethyl]-1,3-dioxo-5-isoindolecarboxylic acid | | 2-[(1R)-1-carboxy-2-(1-naphthalenyl)ethyl]-1,3-dioxo-5-isoindolecarboxylic acid |
| 2-[[(5-anilino-1,3,4-thiadiazol-2-yl)thio]methyl]isoindole-1,3-dione | | 2-[[(5-anilino-1,3,4-thiadiazol-2-yl)thio]methyl]isoindole-1,3-dione |
| 2-[[(6-chloro-4-oxo-3-prop-2-enyl-2-quinazolinyl)thio]methyl]isoindole-1,3-dione | | 2-[[(6-chloro-4-oxo-3-prop-2-enyl-2-quinazolinyl)thio]methyl]isoindole-1,3-dione |
| 2-[[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]thio]methyl]isoindole-1,3-dione | | 2-[[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]thio]methyl]isoindole-1,3-dione |
| 2-[[4-(1,3-dioxo-2-isoindolyl)-1-oxobutyl]amino]-N-(2-furanylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide | | 2-[[4-(1,3-dioxo-2-isoindolyl)-1-oxobutyl]amino]-N-(2-furanylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide |
| 2-[1-(3,4-dihydro-2H-quinolin-1-yl)-1-oxopropan-2-yl]isoindole-1,3-dione | | 2-[1-(3,4-dihydro-2H-quinolin-1-yl)-1-oxopropan-2-yl]isoindole-1,3-dione |
| 2-[2-(4-methylphenoxy)ethyl]isoindole-1,3-dione | | 2-[2-(4-methylphenoxy)ethyl]isoindole-1,3-dione |
| 2-[2-[2-(3-fluorophenyl)-4-thiazolyl]ethyl]isoindole-1,3-dione | | 2-[2-[2-(3-fluorophenyl)-4-thiazolyl]ethyl]isoindole-1,3-dione |
| 2-[2-[2,5-dimethyl-1-(thiophen-2-ylmethyl)-3-pyrrolyl]-2-oxoethyl]isoindole-1,3-dione | | 2-[2-[2,5-dimethyl-1-(thiophen-2-ylmethyl)-3-pyrrolyl]-2-oxoethyl]isoindole-1,3-dione |
| 2-[3-[3-[3-(1-imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione | | 2-[3-[3-[3-(1-imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione |
| 2-fluoro-N-[2-(2-methylpropyl)-1,3-dioxo-5-isoindolyl]benzamide | | 2-fluoro-N-[2-(2-methylpropyl)-1,3-dioxo-5-isoindolyl]benzamide |
| 2-methyl-5-(1-pyrrolidinyl)isoindole-1,3-dione | | 2-methyl-5-(1-pyrrolidinyl)isoindole-1,3-dione |
| 2-thiophenecarboxylic acid 2-(1,3-dioxo-2-isoindolyl)ethyl ester | | 2-thiophenecarboxylic acid 2-(1,3-dioxo-2-isoindolyl)ethyl ester |
| 2,5-dimethoxybenzenesulfonic acid (1,3-dioxo-2-isoindolyl) ester | | 2,5-dimethoxybenzenesulfonic acid (1,3-dioxo-2-isoindolyl) ester |
| 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid | | 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid |
| 4-(1,3-dioxo-2-isoindolyl)-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide | | 4-(1,3-dioxo-2-isoindolyl)-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide |
| 4-(1,3-dioxo-2-isoindolyl)-N-[2-(4-methoxyphenyl)ethyl]butanamide | | 4-(1,3-dioxo-2-isoindolyl)-N-[2-(4-methoxyphenyl)ethyl]butanamide |
| 4-[3-(1,3-dioxo-2-isoindolyl)propylamino]-2-methylisoindole-1,3-dione | | 4-[3-(1,3-dioxo-2-isoindolyl)propylamino]-2-methylisoindole-1,3-dione |
| 4-amino-2-[[4-(1-azepanylsulfonyl)phenyl]-oxomethyl]isoindole-1,3-dione | | 4-amino-2-[[4-(1-azepanylsulfonyl)phenyl]-oxomethyl]isoindole-1,3-dione |
| 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-indole-3-carbonitrile | | 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-indole-3-carbonitrile |
| 5-amino-2-(4-methylphenyl)isoindole-1,3-dione | | 5-amino-2-(4-methylphenyl)isoindole-1,3-dione |
| 5-chloro-N-(1,3-dioxo-5-isoindolyl)-2-thiophenecarboxamide | | 5-chloro-N-(1,3-dioxo-5-isoindolyl)-2-thiophenecarboxamide |
| 5-hydroxythalidomide | | 5-Hydroxythalidomide |
| amphotalide | | amphotalide |
| apremilast | A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis. | apremilast |
| cgp 52411 | Phthalimide substituted at the 4- and 5-positions by anilino groups. | 4,5-dianilinophthalimide |
| cgp 53353 | | 5,6-bis(4-fluoroanilino)isoindole-1,3-dione |
| N-(1,3-dioxo-2-phenyl-5-isoindolyl)-2-thiophenecarboxamide | | N-(1,3-dioxo-2-phenyl-5-isoindolyl)-2-thiophenecarboxamide |
| N-(1,3-dioxo-4-isoindolyl)-2-(2,5-dioxo-1-pyrrolidinyl)acetamide | | N-(1,3-dioxo-4-isoindolyl)-2-(2,5-dioxo-1-pyrrolidinyl)acetamide |
| N-(1,3-dioxo-4-isoindolyl)acetamide | | N-(1,3-dioxo-4-isoindolyl)acetamide |
| N-(1,3-dioxo-5-isoindolyl)-1,3-benzothiazole-6-carboxamide | | N-(1,3-dioxo-5-isoindolyl)-1,3-benzothiazole-6-carboxamide |
| N-(1,3-dioxo-5-isoindolyl)-3-methoxybenzamide | | N-(1,3-dioxo-5-isoindolyl)-3-methoxybenzamide |
| N-(1,3-dioxo-5-isoindolyl)butanamide | | N-(1,3-dioxo-5-isoindolyl)butanamide |
| N-(2-furanylmethyl)-1,3-dioxo-2-propyl-5-isoindolecarboxamide | | N-(2-furanylmethyl)-1,3-dioxo-2-propyl-5-isoindolecarboxamide |
| N-(2,3-dimethylphenyl)-2-[[6-(1,3-dioxo-2-isoindolyl)-1,3-benzothiazol-2-yl]thio]acetamide | | N-(2,3-dimethylphenyl)-2-[[6-(1,3-dioxo-2-isoindolyl)-1,3-benzothiazol-2-yl]thio]acetamide |
| N-(4-acetamidophenyl)-4-(1,3-dioxo-2-isoindolyl)butanamide | | N-(4-acetamidophenyl)-4-(1,3-dioxo-2-isoindolyl)butanamide |
| N-[2-(1-cyclohexenyl)ethyl]-3-(1,3-dioxo-2-isoindolyl)propanamide | | N-[2-(1-cyclohexenyl)ethyl]-3-(1,3-dioxo-2-isoindolyl)propanamide |
| N-[2-(2-methylpropyl)-1,3-dioxo-5-isoindolyl]-2-furancarboxamide | | N-[2-(2-methylpropyl)-1,3-dioxo-5-isoindolyl]-2-furancarboxamide |
| n-phthaloylglutamic acid | A glutamic acid derivative that is L-glutamic acid in which the two hydrogens on the amino group are substituted by a phthaloyl group. | N-phthaloyl-L-glutamic acid |
| nan 190 | An N-alkylpiperazine that consists of (2-methoxyphenyl)piperazine in which the amine hydrogen is substituted by a 4-(2-phthalimido)butyl group. | NAN 190 |
| phosmet | | phosmet |
| phthalimide | A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3. | phthalimide |
| thalidomide | A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. | 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione |