Roles > antidote to benzodiazepine poisoning
Page last updated: 2024-08-05 15:20:45

antidote to benzodiazepine poisoning

A role borne by a molecule that acts to counteract or neutralise the deleterious effects of benzodiazepines.

ChEBI ID: 90757

Members (1)

MemberDefinitionClass
flumazenilAn organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.flumazenil

Research

Studies (4,428)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,006 (22.72)18.7374
1990's1,481 (33.45)18.2507
2000's875 (19.76)29.6817
2010's810 (18.29)24.3611
2020's256 (5.78)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials426 (9.12%)5.53%
Reviews288 (6.16%)6.00%
Case Studies322 (6.89%)4.05%
Observational11 (0.24%)0.25%
Other3,626 (77.59%)84.16%

Protein Targets (76)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency35.481311
arylsulfatase AHomo sapiens (human)Potency0.095311
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.000822
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.005011
cytochrome P450 2C19 precursorHomo sapiens (human)Potency1.584911
cytochrome P450 2C9, partialHomo sapiens (human)Potency13.450411
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency10.000011
endonuclease IVEscherichia coliPotency10.000011
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency0.022411
EWS/FLI fusion proteinHomo sapiens (human)Potency18.345822
flap endonuclease 1Homo sapiens (human)Potency29.934911
GVesicular stomatitis virusPotency13.450411
gemininHomo sapiens (human)Potency0.326411
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency13.450411
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency13.450412
Interferon betaHomo sapiens (human)Potency13.450411
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency2.818411
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency0.112211
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency4.683722
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.100011
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency26.603211
phosphopantetheinyl transferaseBacillus subtilisPotency100.000011
progesterone receptorHomo sapiens (human)Potency21.974622
regulator of G-protein signaling 4Homo sapiens (human)Potency0.006011
survival motor neuron protein isoform dHomo sapiens (human)Potency1.258911
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency4.109511
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.133722
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.031611

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.000811
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC50420.300055
Bile salt export pumpRattus norvegicus (Norway rat)IC501,000.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
GABA theta subunitRattus norvegicus (Norway rat)IC500.003811
GABA theta subunitRattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)IC500.000512
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)Ki0.000855
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)Ki0.0049732
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki0.031799
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)IC500.000512
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)Ki0.000855
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)Ki0.0049732
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)IC500.000512
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)Ki0.000855
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)Ki0.0050732
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.022488
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)IC500.000512
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)Ki0.000855
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)Ki0.0052429
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)Ki0.0049631
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)Ki0.0195631
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Ki0.02921212
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)IC500.000512
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)Ki0.000855
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)Ki0.000922
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)Ki0.0055530
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Ki0.03051515
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)Ki0.02541212
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)Ki0.000922
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)Ki0.000922
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)Ki0.000922
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)IC500.000512
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)Ki0.000855
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)Ki0.01171540
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Ki0.03051515
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)Ki0.000922
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC500.003811
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)Ki0.000922
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Ki0.025577
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)Ki0.000922
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki0.000911
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)Ki0.090011
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Ki0.000911

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)Kd0.002011
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)Kd0.000411
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)Kd0.000511
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)Kd0.000411
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)Kd0.000411
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