A role borne by a molecule that acts to counteract or neutralise the deleterious effects of benzodiazepines.
ChEBI ID: 90757
| Member | Definition | Class |
|---|---|---|
| flumazenil | An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose. | flumazenil |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,006 (22.72) | 18.7374 |
| 1990's | 1,481 (33.45) | 18.2507 |
| 2000's | 875 (19.76) | 29.6817 |
| 2010's | 810 (18.29) | 24.3611 |
| 2020's | 256 (5.78) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 426 (9.12%) | 5.53% |
| Reviews | 288 (6.16%) | 6.00% |
| Case Studies | 322 (6.89%) | 4.05% |
| Observational | 11 (0.24%) | 0.25% |
| Other | 3,626 (77.59%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0953 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0008 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 10.0000 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0224 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.3458 | 2 | 2 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 13.4504 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.3264 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.4504 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 2.8184 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 4.6837 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 0.1000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 100.0000 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 21.9746 | 2 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0060 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.1095 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.1337 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 0.0316 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Kd | 0.0020 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Kd | 0.0004 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Kd | 0.0005 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Kd | 0.0004 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Kd | 0.0004 | 1 | 1 |