A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
| Member | Definition | Class |
|---|
| 32,33,34,35-bacteriohopanetetrol | A hopanoid that is bacteriohopane carrying four hydroxy substituents at positions 32, 33, 34 and 35. | bacteriohopane-32,33,34,35-tetrol |
| 4-nitrocatechol | A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol. | 4-nitrocatechol |
| clonixin | A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a (2-methyl-3-chlorophenyl)amino group. Used (as its lysine salt) for treatment of renal colic, muscular pain and moderately severe migraine attacks. | clonixin |
| curcumin | A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. | curcumin |
| lysine clonixinate | An organoammonium salt obtained by combining clonixin with one molar equivalent of L-lysine. Used for treatment of renal colic, muscular pain and moderately severe migraine attacks. | clonixin lysine salt |
| masoprocol | The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. | masoprocol |
| nigerloxin | A member of the class of benzoic acids that is benzoic acid which is substituted at positions 2, 3, 4, 5, and 6 by carbamoyl, hydroxy, E)-prop-1-en-1-yl, methyl, and methoxy groups, respectively. Obtained from solid-state fermentation of Aspergillus niger CFR-W-105, it inhibits soy bean lipoxygenase-1 (LOX-1) and rat lens aldose reductase (RLAR). It also shows free radical scavenging activity. | nigerloxin |
| patuletin | A trimethoxyflavone that is quercetagetin methylated at position 6. | patuletin |
| procyanidin C1 | A proanthocyanidin consisting of three (-)-epicatechin units joined by two successive (4beta->8)-linkages. | procyanidin C1 |
| proglumetacin | A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. | proglumetacin |
| silychristin | A flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase. | silychristin |
| tepoxalin | A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the control of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs. | tepoxalin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.0328 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 7.5820 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 63.6740 | 3 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.4997 | 2 | 5 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 9.8734 | 2 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 22.2670 | 1 | 3 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 7.0795 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.5111 | 10 | 33 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.9360 | 3 | 11 |
| arylsulfatase A | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 24.8404 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 36.8980 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.7755 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 48.3696 | 2 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 30.4821 | 1 | 2 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 30.4821 | 1 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 21.7145 | 3 | 9 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 31.1732 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.3627 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 6.8660 | 2 | 2 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 5.0119 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 9.8344 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 7.8483 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.1500 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 19.9560 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 7.8483 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 22.8741 | 2 | 2 |
| ClpP | Bacillus subtilis | Potency | 0.6310 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 11.0792 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 7.0871 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 3.1106 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 6.3297 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.5127 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.5230 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 32.7144 | 1 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 8.8422 | 2 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 27.2454 | 2 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 22.7314 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 11.9173 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 45.6547 | 1 | 4 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 34.9688 | 1 | 4 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.2336 | 11 | 27 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.9441 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 22.3448 | 8 | 17 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.7882 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.4235 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.7029 | 5 | 8 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 33.4171 | 2 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 3.1106 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.5127 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 13.2423 | 3 | 5 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.3730 | 3 | 7 |
| GLS protein | Homo sapiens (human) | Potency | 14.4074 | 2 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 33.8631 | 4 | 8 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 52.0159 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 25.5123 | 2 | 4 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.7184 | 2 | 12 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 70.5947 | 2 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 3.1106 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 11.9955 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 35.3310 | 2 | 5 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 7.1264 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 3.1106 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 3.1106 | 1 | 2 |
| interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 15.0676 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 7.9642 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 28.1594 | 3 | 5 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 39.5068 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 24.4485 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 3.5481 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 28.0076 | 1 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0282 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 5.0119 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 16.3427 | 4 | 6 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 11.4413 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 25.2979 | 2 | 10 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 39.2384 | 3 | 8 |
| Parkin | Homo sapiens (human) | Potency | 16.3144 | 3 | 3 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 25.0420 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.3148 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.7024 | 5 | 12 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 28.2619 | 5 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 53.8820 | 1 | 2 |
| PINK1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 11.3855 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 5.0770 | 2 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.3701 | 1 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 28.7610 | 2 | 4 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 79.4328 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 31.8535 | 2 | 4 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 28.9035 | 2 | 6 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 91.9997 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 14.3360 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.6416 | 4 | 8 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.4927 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 44.6684 | 1 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 29.4197 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 29.4197 | 2 | 4 |
| Smad3 | Homo sapiens (human) | Potency | 20.3436 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.0602 | 2 | 18 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 24.2482 | 2 | 5 |
| Thrombopoietin | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.1686 | 3 | 13 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 52.1315 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 23.7106 | 5 | 6 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 27.7247 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 34.7421 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 20.0057 | 2 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 29.8834 | 5 | 8 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 40.0748 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 52.0159 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 9.6995 | 2 | 2 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 1.7300 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 31.4000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 132.1300 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 81.0100 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 3.5000 | 3 | 3 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 2.5733 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 21.5000 | 1 | 1 |
| Aminopeptidase N | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 15.5000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 9.8541 | 30 | 30 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 7.7510 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 343.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 1.6300 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 2.3600 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.1010 | 1 | 1 |
| Chain A, Protocatechuate 3,4-dioxygenase Alpha Chain | Acinetobacter baylyi ADP1 | Ki | 0.9000 | 1 | 1 |
| Chain B, Protocatechuate 3,4-dioxygenase Beta Chain | Acinetobacter baylyi ADP1 | Ki | 0.9000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 300.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| CREB-binding protein | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 7.7500 | 1 | 1 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 1.0700 | 2 | 2 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 69.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 17.9500 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 0.0660 | 1 | 1 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 21.9167 | 6 | 6 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 50.7900 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 97.6700 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 64.9800 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| hypothetical protein SA1422 | Staphylococcus aureus subsp. aureus N315 | IC50 | 42.9000 | 2 | 2 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 18.7000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 9.6000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 53.2000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 54.8750 | 4 | 4 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 38.6000 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 38.6000 | 1 | 2 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 24.2000 | 1 | 1 |
| Neuronal proto-oncogene tyrosine-protein kinase Src | Mus musculus (house mouse) | IC50 | 2.2000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 9.1670 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 10.2320 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 11.1000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 16.0000 | 2 | 2 |
| Polyphenol oxidase 2 | Agaricus bisporus | Ki | 8.7000 | 4 | 4 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 0.6667 | 3 | 3 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 1.8000 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 28.8040 | 3 | 5 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 3.5250 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 28.8040 | 3 | 5 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 3.5250 | 2 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 145.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 31.7500 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 31.7500 | 1 | 2 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 3.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Rattus norvegicus (Norway rat) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | Ki | 8.6000 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 6.7500 | 1 | 2 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| Sortase A | Streptococcus mutans | IC50 | 10.2000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 0.0132 | 1 | 1 |
| toll-like receptor 9 | Homo sapiens (human) | IC50 | 8.3620 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 19.7000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |