An antagonist that acts on glutamine receptors.
ChEBI ID: 138931
| Member | Definition | Class |
|---|---|---|
| acivicin | An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria. | acivicin |
| azaserine | A carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species. | azaserine |
| diazooxonorleucine | A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. | 6-diazo-5-oxo-L-norleucine zwitterion; 6-diazo-5-oxo-L-norleucine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 691 (54.71) | 18.7374 |
| 1990's | 291 (23.04) | 18.2507 |
| 2000's | 134 (10.61) | 29.6817 |
| 2010's | 105 (8.31) | 24.3611 |
| 2020's | 42 (3.33) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 14 (1.01%) | 5.53% |
| Reviews | 50 (3.60%) | 6.00% |
| Case Studies | 2 (0.14%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,321 (95.24%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 1.7901 | 2 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 39.8107 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 36.9010 | 8 | 9 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 3.0432 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 6.6824 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.7389 | 5 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.0025 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.0310 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 27.3060 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 0.0013 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 10.5909 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 11.6830 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 2.9849 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |