An insecticide compound naturally occurring in plants.
ChEBI ID: 22917
| Member | Definition | Class |
|---|---|---|
| canaline | A non-proteinogenic L-alpha-amino acid that is L-homoserine in which the hydroxy group at position 4 is substituted by an aminooxy group. It has been isolated from legumes and plays an essential role in lugume chemical defense against insects. | L-canaline zwitterion; L-canaline |
| canavanine | A non-proteinogenic L-alpha-amino acid that is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. Although structurally related to L-arginine, it is non-proteinogenic. | L-canavanine zwitterion; L-canavanine |
| erysodine | An erythrina alkaloid with formula C18H21NO3 isolated from several erythrina plant species. It is a competitive antagonist of nicotinic acetylcholine receptors and exhibits antiparasitic and insecticidal activities. | erysodine |
| megestrol acetate | A sesquiterpene lactone with formula C15H20O8. It is a neurotoxic natural product found in plants of the family Illiciaceae. | anisatin |
| nicotine | A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. | (S)-nicotine |
| rotenone | A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). | rotenone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 7,775 (24.22) | 18.7374 |
| 1990's | 4,753 (14.80) | 18.2507 |
| 2000's | 7,690 (23.95) | 29.6817 |
| 2010's | 8,513 (26.52) | 24.3611 |
| 2020's | 3,374 (10.51) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,286 (6.79%) | 5.53% |
| Reviews | 2,832 (8.41%) | 6.00% |
| Case Studies | 372 (1.10%) | 4.05% |
| Observational | 54 (0.16%) | 0.25% |
| Other | 28,146 (83.54%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 29.8312 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 1.4034 | 7 | 20 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 2.3934 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.2310 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.8492 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 0.1346 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 0.0826 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.2511 | 3 | 7 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 11.2202 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 38.3067 | 1 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.1655 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 5.4950 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 28.0558 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.1458 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 0.0465 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.1575 | 10 | 27 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.2138 | 1 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0210 | 9 | 20 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 27.3601 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 2.6196 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 21.9534 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 3.3173 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 6.1655 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 3.9220 | 4 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.5195 | 2 | 7 |
| GLS protein | Homo sapiens (human) | Potency | 11.2202 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 34.5962 | 4 | 6 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.0300 | 1 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 49.8391 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.1655 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 20.2576 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.1655 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.3085 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 4.9974 | 3 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 1.4036 | 2 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.3096 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 19.2886 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 17.8956 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0316 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 39.8107 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 290.9290 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 12.9660 | 3 | 8 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 58.7082 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 5.9931 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 6.7260 | 2 | 6 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0683 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 0.0478 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 22.1352 | 3 | 5 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 19.4804 | 3 | 3 |
| polyprotein | Zika virus | Potency | 3.3173 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 1.8557 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 13.8660 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 18.6626 | 2 | 4 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.2184 | 2 | 6 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 73.0780 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 6.0944 | 1 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 4.3188 | 2 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 5.1105 | 4 | 8 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.0525 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.1077 | 1 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.1077 | 1 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 3.1623 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.0341 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.0631 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.9843 | 2 | 5 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 17.2576 | 1 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 3.7376 | 2 | 7 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.2266 | 4 | 10 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.1703 | 1 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 28.0589 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 7.6152 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.0300 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.8700 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.4040 | 1 | 1 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | IC50 | 11.0000 | 2 | 2 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | IC50 | 4.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | Ki | 2.7000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 0.2236 | 7 | 8 |
| Acyl carrier protein, mitochondrial | Bos taurus (cattle) | IC50 | 0.0051 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 319.0000 | 3 | 4 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4,100.0000 | 1 | 1 |
| Cytochrome P450 2A13 | Homo sapiens (human) | Ki | 72.0000 | 1 | 1 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 159.9560 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 210.6763 | 2 | 3 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 46.2667 | 3 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.6486 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 26.3000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.4400 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| Dihydroorotate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase (fumarate) | Saccharomyces cerevisiae S288C | IC50 | 10.0000 | 1 | 1 |
| Liver carboxylesterase B-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0450 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.2260 | 2 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.4400 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | Ki | 2.1100 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 1.0597 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) | IC50 | 0.0051 | 1 | 1 |
| NADH-ubiquinone oxidoreductase chain 1 | Bos taurus (cattle) | IC50 | 0.0150 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.0595 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0438 | 27 | 28 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 0.3899 | 4 | 4 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 5.0025 | 4 | 4 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.3763 | 20 | 20 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | Ki | 0.0841 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.2178 | 37 | 42 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 0.3456 | 10 | 12 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 0.0055 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0046 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | Ki | 0.0019 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.3349 | 31 | 31 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0204 | 72 | 85 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 0.0848 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | IC50 | 14.3000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | IC50 | 0.0087 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Ki | 6.0101 | 18 | 20 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | Ki | 0.2406 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 3.1729 | 16 | 20 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | IC50 | 0.0041 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | IC50 | 0.3256 | 11 | 13 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0046 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.3306 | 31 | 31 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | Ki | 0.0024 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0124 | 76 | 85 |
| Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (human) | IC50 | 0.0848 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | IC50 | 0.7150 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 5.0025 | 4 | 4 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | Ki | 0.3463 | 22 | 22 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | Ki | 0.0572 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Ki | 0.1748 | 54 | 63 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 60.0000 | 2 | 2 |
| Nitric oxide synthase, inducible | Homo sapiens (human) | Ki | 220.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 500.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 245.0807 | 5 | 6 |
| Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Ki | 1.0466 | 3 | 3 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 64.3000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 50.5000 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 0.5063 | 2 | 4 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 5.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | EC50 | 25.3333 | 3 | 3 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | EC50 | 29.0000 | 3 | 3 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | EC50 | 33.0000 | 2 | 2 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | EC50 | 110.0000 | 2 | 2 |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | EC50 | 65.0000 | 1 | 1 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | EC50 | 33.0000 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Kd | 0.2931 | 3 | 5 |
| Cytochrome P450 2A13 | Homo sapiens (human) | Kd | 54.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Kd | 470.0000 | 1 | 1 |
| Glycoprotein IIb | Oryctolagus cuniculus (rabbit) | EC50 | 1.5068 | 1 | 4 |
| Integrin beta | Oryctolagus cuniculus (rabbit) | EC50 | 1.5068 | 1 | 4 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | EC50 | 40.6667 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | EC50 | 21.3260 | 14 | 15 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | EC50 | 30.2517 | 7 | 8 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | EC50 | 3.1424 | 20 | 24 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | EC50 | 10.7398 | 12 | 12 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-5 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (human) | EC50 | 0.1270 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | EC50 | 55.2158 | 6 | 6 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | EC50 | 3,948.0836 | 10 | 11 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Kd | 0.0011 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | EC50 | 9.3127 | 23 | 27 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 10.7398 | 12 | 12 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (human) | EC50 | 10.5635 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | EC50 | 13.6576 | 14 | 15 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | EC50 | 30.2517 | 7 | 8 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 152,369.0000 | 2 | 3 |
| Transient receptor potential cation channel subfamily A member 1 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | EC50 | 51.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Activity | 53.2000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 1 |