Any EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of a glutaminase (EC 3.5.1.2) and thus the generation of glutamate from glutamine.
ChEBI ID: 60280
| Member | Definition | Class |
|---|---|---|
| compound 968 | A partially hydrogenated benzophenanthridine carrying an oxo group at C-4, geminal methyl groups at C-2 and a 3-bromo-4-(dimethylamino)phenyl group at C-5. | 5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one |
| diazooxonorleucine | A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. | 6-diazo-5-oxo-L-norleucine zwitterion; 6-diazo-5-oxo-L-norleucine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 168 (48.41) | 18.7374 |
| 1990's | 52 (14.99) | 18.2507 |
| 2000's | 35 (10.09) | 29.6817 |
| 2010's | 59 (17.00) | 24.3611 |
| 2020's | 33 (9.51) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.28%) | 5.53% |
| Reviews | 15 (4.19%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 342 (95.53%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.5768 | 3 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 37.2212 | 1 | 1 |
| polyprotein | Zika virus | Potency | 37.2212 | 1 | 1 |