A drug used to treat psoriasis.
| Member | Definition | Class |
|---|
| an2728 | A member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults. | crisaborole |
| anthralin | An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9. | anthralin |
| azaribine | A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis. | azaribine |
| benoxaprofen | A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals. | benoxaprofen |
| betamethasone-17,21-dipropionate | A steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasis in adult patients. | betamethasone dipropionate |
| calcipotriene | A seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. | calcipotriol |
| calcipotriene | A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. | calcipotriol hydrate |
| calcitriol | A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. | calcitriol |
| delgocitinib | A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan. | delgocitinib |
| dimethyl fumarate | An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis. | dimethyl fumarate |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 15.7191 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.3847 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 12.4416 | 8 | 10 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 15.2804 | 2 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 54.5388 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 16.1828 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 17.5594 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 18.3174 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.7340 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 23.7531 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 4.2311 | 6 | 10 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 1.6508 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 3.9844 | 5 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.4283 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 31.7859 | 2 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.7063 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 36.3512 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 15.3684 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.5827 | 3 | 5 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 3.2643 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 1.4219 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 0.6949 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 15.3793 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 3.2643 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 32.9993 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 21.1699 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.2593 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 14.8563 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.4574 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.7265 | 2 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 7.0867 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.0112 | 1 | 1 |
| polyprotein | Zika virus | Potency | 36.3512 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 32.9993 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 2.1132 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 0.5956 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 8.9202 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 36.5069 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.1314 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 3.2643 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.1114 | 2 | 5 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 32.5548 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 216.7942 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.0112 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.0112 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 53.2304 | 1 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0006 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 69.6219 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-lipoxygenase | Bos taurus (cattle) | IC50 | 32.0000 | 5 | 5 |
| Androgen receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Beta-lactamase | Klebsiella pneumoniae | IC50 | 0.6700 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 112.8500 | 3 | 4 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 99.1000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Homo sapiens (human) | IC50 | 2,803.0500 | 2 | 2 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | IC50 | 17,900.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Homo sapiens (human) | IC50 | 71,000.0000 | 1 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (human) | IC50 | 97,600.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 0.2862 | 4 | 4 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 10.1796 | 7 | 7 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | IC50 | 0.2862 | 4 | 4 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 0.3270 | 5 | 5 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 3,630.0000 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 32,003.2000 | 2 | 2 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 29,403.2000 | 2 | 2 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 56,100.0000 | 1 | 1 |
| core protein, partial | | IC50 | 49.7510 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.0093 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.0093 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0052 | 1 | 1 |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | Homo sapiens (human) | IC50 | 1,015.3650 | 2 | 2 |
| microphthalmia-associated transcription factor isoform 9 | Homo sapiens (human) | IC50 | 4.3992 | 3 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 151.2000 | 3 | 3 |
| Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (human) | IC50 | 0.0533 | 3 | 3 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| Tyrosine-protein kinase JAK1 | Homo sapiens (human) | IC50 | 0.0203 | 6 | 6 |
| Tyrosine-protein kinase JAK2 | Homo sapiens (human) | IC50 | 0.0745 | 6 | 6 |
| Tyrosine-protein kinase JAK3 | Homo sapiens (human) | IC50 | 0.0220 | 3 | 3 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| Vitamin D3 receptor | Bos taurus (cattle) | IC50 | 0.0000 | 1 | 1 |
| Vitamin D3 receptor | Homo sapiens (human) | IC50 | 0.3401 | 19 | 19 |
| Vitamin D3 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 11 | 11 |