Page last updated: 2024-08-05 10:57:44
quinolone
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ChEBI ID: 23765
Members (41)
| Member | Definition | Role |
|---|---|---|
| 2-heptyl-3-hydroxy-4-quinolone | A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2 and a hydroxy group at position 3. | 2-heptyl-3-hydroxy-4-quinolone |
| 2,4-dihydroxyquinoline | A heteroaryl hydroxy compound that is 2-quinolone substituted at position 4 by a hydroxy group. | 4-hydroxy-2-quinolone |
| 2,8-dihydroxyquinoline | 8-hydroxyquinolin-2(1H)-one; quinoline-2,8-diol | |
| 3-benzyl-4-hydroxyquinolin-2(1H)-one | 3-benzyl-4-hydroxyquinolin-2(1H)-one | |
| 3-hydroxyquinolin-2(1h)-one | Quinolinediol | |
| 4-hydroxyquinoline | A quinolone that is 1,4-dihydroquinoline substituted by an oxo group at position 4. | 4-quinolone; quinolin-4-ol |
| 4-methylquinolin-2(1H)-one | A quinolone that is quinolin-2(1H)-one substituted by a methyl group at position 4. | 4-methylquinolin-2(1H)-one |
| 6-anilino-5,8-quinolinedione | A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group. | 6-anilino-5,8-quinolinedione |
| 6-chloro-4-hydroxy-3-(phenylmethyl)-1H-quinolin-2-one | 6-chloro-4-hydroxy-3-(phenylmethyl)-1H-quinolin-2-one | |
| 7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one | 7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one | |
| 7-hydroxy-4-methyl-1H-quinolin-2-one | 7-hydroxy-4-methyl-1H-quinolin-2-one | |
| aripiprazole | An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders. | aripiprazole |
| aripiprazole lauroxil | A dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripiprazole, it is used for treatment of schizophrenia. | aripiprazole lauroxil |
| as 1842856 | A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. | AS1842856 |
| aurachin c | A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3. | aurachin C |
| bay-s 9435 | An organosulfonic acid that is ciprofloxacin carrying a sulfo group at position 4 of the piperazine ring. It is a metabolite of ciprofloxacin. | sulfociprofloxacin |
| carbostyril | A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2. | quinolin-2-ol; quinolin-2(1H)-one |
| carteolol | carteolol | |
| ciprofloxacin | A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. | ciprofloxacin zwitterion; ciprofloxacin |
| diazaquinomycin a | Diazaquinomycin A | |
| difloxacin | A quinolone that is pefloxacin in which the ethyl group at position 1 of the quinolone has been replaced by a p-fluorophenyl group. A broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria, it is used (usually as the monohydrochloride salt) for the treatment of bacterial infections in dogs. | difloxacin |
| enrofloxacin | A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets. | enrofloxacin |
| finafloxacin | A quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, 7 and 8 by cyclopropyl, fluoro, hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl and cyano groups respectively; an antibiotic used for treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. | finafloxacin |
| gatifloxacin | A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes. | gatifloxacin |
| hei 712 | 6-Fluoro-2-methylquinolin-4-ol | |
| huperzine a | LSM-1581 | |
| indacaterol | A monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary disease. | indacaterol |
| jtk-303 | A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is used in combination therapy for the treatment of HIV-1 infection. | elvitegravir |
| lomefloxacin | A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. | lomefloxacin |
| moxifloxacin | A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents. | moxifloxacin |
| my 12-62c | A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2. | 2-heptyl-4-hydroxyquinoline; 2-heptyl-4-quinolone |
| n-methylcorydaldine | N-methylcorydaldine | |
| norfloxacin | A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase. | norfloxacin |
| nsc 663284 | 6-chloro-7-[2-(4-morpholinyl)ethylamino]quinoline-5,8-dione | |
| oxociprofloxacin | 3-oxociprofloxacin | |
| pefloxacin | A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively. | pefloxacin |
| sparfloxacin | sparfloxacin | |
| streptonigrin | Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia. | streptonigrin |
| temafloxacin | A quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, and 7 by 2,4-difluorophenyl, fluorine, and 3-methylpiperazin-1-yl groups, respectively. | 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| tipifarnib | A quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). | tipifarnib |
| vx-770 | An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis. | ivacaftor |
Research
Studies (36,076)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,720 (7.54) | 18.7374 |
| 1990's | 6,505 (18.03) | 18.2507 |
| 2000's | 9,403 (26.06) | 29.6817 |
| 2010's | 12,806 (35.50) | 24.3611 |
| 2020's | 4,642 (12.87) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,996 (10.64%) | 5.53% |
| Reviews | 3,466 (7.38%) | 6.00% |
| Case Studies | 4,555 (9.70%) | 4.05% |
| Observational | 255 (0.54%) | 0.25% |
| Other | 33,698 (71.74%) | 84.16% |