A family of cyclic heptapeptide hepatotoxins produced by a number of cyanobacteria, the most notable of which is Microcystis, from which the name of the family is derived. Microcystins consist of a heptapeptide macrocycle made up of five non-protein amino acids and two protein amino acids.
ChEBI ID: 48041
| Member | Definition | Role |
|---|---|---|
| cyanoginosin lr | A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. | microcystin-LR |
| microcystin rr | microcystin RR | |
| microcystin-lf | A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl, L-phenylalanyl, (2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. | microcystin LF |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 11 (0.70) | 18.7374 |
| 1990's | 166 (10.54) | 18.2507 |
| 2000's | 412 (26.16) | 29.6817 |
| 2010's | 734 (46.60) | 24.3611 |
| 2020's | 252 (16.00) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.06%) | 5.53% |
| Reviews | 25 (1.47%) | 6.00% |
| Case Studies | 5 (0.29%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,674 (98.18%) | 84.16% |