A group of indole-indoline dimers which are alkaloids obtained from the Vinca genus of plants, together with semi-synthetic and fully synthetic analogues.
ChEBI ID: 27288
| Member | Definition | Role |
|---|---|---|
| 4-desacetylvinblastine | Desacetylvinblastine | |
| vincaleukoblastine | vincaleukoblastine | |
| vincamine | vincamine | |
| vincristine | A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. | vincristine |
| vindesine | vindesine | |
| vinflunine | An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethyl group attached to this ring has been replaced by a 1,1-difluoroethyl group. | vinflunine |
| vinorelbine | A vinca alkaloid with a norvinblastine skeleton. | vinorelbine |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 670 (33.80) | 18.7374 |
| 1990's | 498 (25.13) | 18.2507 |
| 2000's | 351 (17.71) | 29.6817 |
| 2010's | 383 (19.32) | 24.3611 |
| 2020's | 80 (4.04) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 500 (23.19%) | 5.53% |
| Reviews | 156 (7.24%) | 6.00% |
| Case Studies | 168 (7.79%) | 4.05% |
| Observational | 5 (0.23%) | 0.25% |
| Other | 1,327 (61.55%) | 84.16% |