A Daphnia metabolite produced by the species Daphnia galeata.
| Member | Definition | Class |
|---|
| arachidonic acid | A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14. | arachidonic acid |
| eicosapentaenoic acid | An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17. | all-cis-5,8,11,14,17-icosapentaenoic acid |
| linoleic acid | An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry. | linoleic acid |
| oleic acid | An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry. | oleic acid |
| palmitoleic acid | A hexadec-9-enoic acid in which the double bond at position C-9 has cis configuration. | palmitoleic acid |
| stearidonic acid | An octadecatetraenoic acid having four double bonds located at positions 6, 9, 12 and 15 (the all-cis-isomer). It has been isolated from Lithospermum officinale and fish oils. | all-cis-octadeca-6,9,12,15-tetraenoic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 14.9047 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.1847 | 1 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 89.3584 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 45.7918 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.0888 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 19.6703 | 6 | 11 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.5750 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 60.1373 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 60.1373 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.3667 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 26.6514 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.4536 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 35.4813 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 27.8298 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 16.3177 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 7.8758 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 37.0084 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 16.3177 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 26.4589 | 2 | 6 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 33.4983 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 18.0232 | 1 | 5 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.3368 | 4 | 10 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 46.2184 | 2 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 54.0150 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.4304 | 1 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 32.1480 | 2 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 26.4589 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 19.8754 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 23.6269 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 42.9050 | 2 | 5 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 49.4600 | 2 | 8 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 30.5011 | 1 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 32.9838 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 58.9114 | 2 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.0134 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 73.2757 | 2 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.9410 | 2 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 61.1306 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 41.4100 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 34.1951 | 2 | 3 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 32.1968 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 32.3510 | 5 | 16 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 35.9537 | 1 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 61.3506 | 1 | 4 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 60.6340 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 31.4536 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 45.6614 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 23.5697 | 2 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 36.3070 | 4 | 6 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 10.6213 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 33.7354 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 33.7354 | 2 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.4537 | 2 | 6 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 17.7828 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 89.1251 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 54.8582 | 2 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 52.8853 | 2 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 47.0887 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 11.0362 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 17.7925 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 12.6500 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 12.6500 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 65.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 0.6900 | 2 | 2 |
| Aromatase | Homo sapiens (human) | IC50 | 40.5250 | 1 | 4 |
| Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta)) | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 84.8000 | 1 | 5 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 7.6320 | 1 | 1 |
| Cytosolic phospholipase A2 gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 31.0000 | 1 | 1 |
| Dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty acid-binding protein 5 | Homo sapiens (human) | Ki | 2.8898 | 2 | 10 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | IC50 | 12.2300 | 4 | 5 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | Ki | 2.8283 | 2 | 3 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | IC50 | 1.0000 | 3 | 3 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | Ki | 9.3000 | 1 | 1 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 1.5400 | 2 | 2 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Oxoeicosanoid receptor 1 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 227.6667 | 1 | 3 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 200.3667 | 1 | 3 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Ki | 7.6320 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 8.3333 | 3 | 3 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Ki | 22.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 0.6026 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 0.3300 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 1.0715 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 4 |
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 2 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 84.8000 | 1 | 5 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 4 |
| Trypsin | Sus scrofa (pig) | IC50 | 200.0000 | 1 | 5 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 6.3000 | 1 | 2 |
| Tyrosine-protein phosphatase non-receptor type 7 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |