Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
ChEBI ID: 65191
| Member | Definition | Class |
|---|---|---|
| amperozide | A member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs. | amperozide |
| amperozide hydrochloride | The hydrochloride salt of amperozide. | amperozide hydrochloride |
| aripiprazole | An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders. | aripiprazole |
| aripiprazole lauroxil | A dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripiprazole, it is used for treatment of schizophrenia. | aripiprazole lauroxil |
| clozapine | A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. | clozapine |
| dan 2163 | A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects. | amisulpride |
| hp 873 | A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia. | iloperidone |
| lurasidone | An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizophrenia. | lurasidone |
| lurasidone hydrochloride | A hydrochloride obtained by reaction of lurasidone with one equivalent of hydrochloric acid. An atypical antipsychotic agent used for the treatment of schizophrenia. | lurasidone hydrochloride |
| olanzapine | A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4. | olanzapine |
| quetiapine | quetiapine | |
| risperidone | A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2. | risperidone |
| sertindole | A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group. | sertindole |
| zotepine | zotepine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 699 (3.26) | 18.7374 |
| 1990's | 3,525 (16.42) | 18.2507 |
| 2000's | 7,516 (35.00) | 29.6817 |
| 2010's | 7,333 (34.15) | 24.3611 |
| 2020's | 2,401 (11.18) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,468 (16.00%) | 5.53% |
| Reviews | 3,570 (12.78%) | 6.00% |
| Case Studies | 5,653 (20.24%) | 4.05% |
| Observational | 202 (0.72%) | 0.25% |
| Other | 14,039 (50.26%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 14.1254 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 20.9198 | 4 | 14 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 18.3062 | 8 | 37 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.4915 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.5248 | 3 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 17.6436 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 13.4404 | 1 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.1274 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 26.6032 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 3 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 26.6032 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 21.5845 | 2 | 6 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 11.6427 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 74.9307 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 20.5348 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 13.3519 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 30.0351 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 5.2846 | 1 | 8 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 9.4974 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.0011 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 19.2031 | 2 | 7 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 29.3241 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.4778 | 3 | 6 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 7.9433 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.0695 | 8 | 39 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 28.7675 | 2 | 7 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 15.8206 | 9 | 31 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.5735 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.9457 | 4 | 14 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.3094 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 23.8460 | 1 | 5 |
| G | Vesicular stomatitis virus | Potency | 30.0351 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.0011 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 11.7563 | 2 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.6070 | 2 | 13 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 16.2072 | 2 | 4 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 13.5481 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 20.6358 | 2 | 11 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 21.6945 | 1 | 5 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 31.0610 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 21.2045 | 2 | 9 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 55.5628 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 30.0351 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 16.1190 | 1 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 13.3413 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 30.0351 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 6.7365 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 23.1846 | 3 | 8 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.4361 | 1 | 6 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 28.0102 | 2 | 2 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 3.0600 | 3 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.1696 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.7265 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 11.0116 | 2 | 6 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 1.7783 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 1.7783 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.0000 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.8532 | 2 | 9 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 25.8598 | 2 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 20.2593 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 17.7255 | 3 | 18 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 79.4328 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 14.1104 | 1 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 63.6322 | 1 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.1334 | 3 | 6 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 13.5170 | 3 | 9 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| polyprotein | Zika virus | Potency | 23.8460 | 1 | 5 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 11.9014 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 8.6331 | 1 | 7 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 20.3230 | 2 | 7 |
| progesterone receptor | Homo sapiens (human) | Potency | 22.5726 | 1 | 5 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 17.5787 | 2 | 11 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 79.4328 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 28.1559 | 3 | 11 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 11.7049 | 2 | 9 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 24.0203 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 24.0203 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 24.7175 | 2 | 9 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.0107 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.8033 | 2 | 33 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 25.7886 | 3 | 7 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.9663 | 3 | 21 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 27.8910 | 5 | 14 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 5.3018 | 1 | 3 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 17.6393 | 2 | 7 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 18.0455 | 3 | 8 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 21.6945 | 1 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0170 | 1 | 5 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | IC50 | 0.8800 | 2 | 3 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.2172 | 3 | 6 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.5089 | 29 | 57 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.2855 | 12 | 17 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.6689 | 3 | 5 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.3941 | 2 | 4 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Bos taurus (cattle) | IC50 | 0.0090 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.2972 | 8 | 15 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | IC50 | 0.0148 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0651 | 16 | 25 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0242 | 65 | 116 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0081 | 28 | 44 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0882 | 2 | 7 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | IC50 | 0.0148 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0180 | 11 | 17 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0731 | 7 | 14 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0121 | 8 | 9 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.4891 | 8 | 16 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0176 | 12 | 18 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.1507 | 30 | 68 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0177 | 16 | 18 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | IC50 | 0.0148 | 1 | 2 |
| 5-hydroxytryptamine receptor 3A | Cavia porcellus (domestic guinea pig) | IC50 | 370.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.3410 | 3 | 5 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 0.0320 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.3797 | 2 | 4 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.3797 | 2 | 4 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.3797 | 2 | 4 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.3797 | 2 | 4 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5956 | 2 | 6 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.3096 | 2 | 6 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.2239 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0163 | 4 | 5 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.2447 | 33 | 54 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 0.0157 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.2292 | 36 | 53 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0301 | 3 | 5 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.2190 | 1 | 2 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.4700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.4580 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0703 | 5 | 8 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0460 | 9 | 10 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0004 | 3 | 3 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0186 | 10 | 25 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3182 | 14 | 30 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0508 | 8 | 9 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0180 | 8 | 20 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 0.0003 | 3 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3304 | 15 | 29 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0584 | 1 | 4 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0508 | 8 | 9 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0198 | 9 | 24 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.3268 | 16 | 29 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.7830 | 1 | 4 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.3849 | 3 | 3 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.3106 | 6 | 20 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0879 | 6 | 11 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.1426 | 1 | 4 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3239 | 3 | 15 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1029 | 4 | 8 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.2423 | 1 | 4 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2560 | 5 | 19 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1029 | 4 | 8 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 29.1903 | 2 | 4 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 3.0399 | 2 | 4 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 7 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 3.6400 | 1 | 2 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 19.3333 | 2 | 3 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.1500 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 100.5508 | 4 | 13 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 196.5000 | 1 | 1 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 80.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 7 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | Ki | 0.0600 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 5.2734 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.1652 | 1 | 10 |
| D | Bos taurus (cattle) | IC50 | 4.0900 | 2 | 2 |
| D | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | IC50 | 1.0661 | 8 | 12 |
| D | Bos taurus (cattle) | Ki | 0.4200 | 8 | 13 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.2040 | 15 | 32 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.2718 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.3797 | 18 | 36 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 1.0445 | 4 | 4 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1742 | 2 | 2 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 1.8040 | 5 | 5 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.1681 | 15 | 21 |
| D(2) dopamine receptor | Mus musculus (house mouse) | IC50 | 0.1565 | 1 | 4 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.4520 | 24 | 40 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.6900 | 1 | 1 |
| D(2) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.2540 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0729 | 112 | 162 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1027 | 31 | 69 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.3946 | 2 | 5 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(3) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.4660 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.2218 | 53 | 86 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.2457 | 6 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.0868 | 12 | 13 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.2288 | 61 | 83 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1583 | 6 | 6 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 102.0000 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0126 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 0.8975 | 2 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gastrin/cholecystokinin type B receptor | Mus musculus (house mouse) | Ki | 0.0038 | 1 | 2 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 497.2000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.3355 | 6 | 12 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 2 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0459 | 3 | 6 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0305 | 15 | 36 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 2.5465 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 2.5040 | 1 | 2 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 1.2744 | 3 | 4 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 0.1925 | 3 | 3 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 65.8000 | 1 | 2 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 395.5000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 7 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.6609 | 3 | 4 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.1233 | 4 | 7 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.0576 | 7 | 19 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0136 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.9104 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.7769 | 2 | 7 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0356 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 42.0940 | 3 | 5 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.3953 | 5 | 7 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 1.5971 | 2 | 7 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.5929 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 1.0025 | 4 | 12 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 1.0179 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 1.6593 | 2 | 8 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic receptor M1 | Bos taurus (cattle) | IC50 | 1.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 38.2537 | 1 | 3 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 6.0467 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.7680 | 1 | 1 |
| Potassium voltage-gated channel subfamily A member 5 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 2.5810 | 31 | 63 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 10.7326 | 6 | 12 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.1788 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 4.7320 | 2 | 2 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 40.4000 | 3 | 3 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.1797 | 4 | 7 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.0210 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.4700 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 0.4875 | 2 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.7895 | 1 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 3.8644 | 7 | 11 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 125.0000 | 1 | 2 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 5.4541 | 2 | 7 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 8.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 35.6000 | 5 | 5 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 13.2500 | 4 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 13.2500 | 4 | 4 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 13.2500 | 4 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 3.4363 | 3 | 3 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Kd | 0.8285 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | EC50 | 8.3930 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 0.1259 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 0.2500 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 61.3000 | 1 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Calmodulin | Bos taurus (cattle) | Kd | 61.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 0.8222 | 23 | 28 |
| D(3) dopamine receptor | Homo sapiens (human) | EC50 | 0.0198 | 2 | 4 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 0.3200 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | EC50 | 0.0004 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Kd | 0.0016 | 1 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Kd | 0.0294 | 4 | 4 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 92.4690 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 40.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| short transient receptor potential channel 6 isoform 1 | Mus musculus (house mouse) | EC50 | 15.8500 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Activity | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | INH | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | INH | 0.0064 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Activity | 0.0010 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Activity | 0.0032 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Activity | 0.0090 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 22.7500 | 1 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Km | 43.7667 | 3 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Km | 45.2400 | 4 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Activity | 0.2560 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | pKi | 0.0069 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | pKi | 0.0066 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | pKi | 0.0073 | 1 | 1 |
| FAD-linked sulfhydryl oxidase ALR | Homo sapiens (human) | AC50 | 0.3690 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Activity | 0.0012 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | INH | 0.0012 | 1 | 1 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 144.5000 | 2 | 2 |