A compound containing at least one carbon-bromine bond.
| Member | Definition | Role |
|---|
| (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene | An organobromine compound that is bromobenzene in which the hydrogens at positions 2 and 5 are replaced by 4-hydroxystyryl groups. | (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene |
| 1-azakenpaullone | An organic heterotetracyclic compound that is 7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indole substituted at positions 6 and 9 by oxo and bromo groups respectively. | 1-azakenpaullone |
| 1-bromo-2-chloroethane | A haloalkane that is bromoethane substituted by chlorine at position 2. | 1-bromo-2-chloroethane |
| 1-bromo-2,4-dinitrobenzene | An organobromine compound that is bromobenzene substituted at C-2 and -4 with nitro groups. | 2,4-dinitrobromobenzene |
| 1,2-dibromo-2,4-dicyanobutane | An organobromine compound that consists of pentanedinitrile bearing bromo and bromomethyl substituents at position 2. | 2-bromo-2-(bromomethyl)pentanedinitrile |
| 2-(4-bromophenyl)-3,5-dimethyl-4-oxido-6-phenylpyrazin-1-ium 1-oxide | | 2-(4-bromophenyl)-3,5-dimethyl-4-oxido-6-phenylpyrazin-1-ium 1-oxide |
| 2-(4-bromophenyl)-5-(2-methylphenyl)-1,3,4-oxadiazole | | 2-(4-bromophenyl)-5-(2-methylphenyl)-1,3,4-oxadiazole |
| 2-(4-bromophenyl)thiazolidine | | 2-(4-bromophenyl)thiazolidine |
| 2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid | | 2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid |
| 2-amino-4-[(4-bromophenyl)methylthio]-3-azaspiro[5.5]undeca-1,4-diene-1,5-dicarbonitrile | | 2-amino-4-[(4-bromophenyl)methylthio]-3-azaspiro[5.5]undeca-1,4-diene-1,5-dicarbonitrile |
| 2,2',4,4'-tetrabromodiphenyl ether | | 2,2',4,4'-Tetrabromodiphenyl ether |
| 2,2',4,4',5,5'-hexabrominated diphenyl ether | | 2,2',4,4',5,5'-Hexabromodiphenyl ether |
| 2,2',4,5'-tetrabromodiphenyl ether | | 2,2',4,5'-Tetrabromodiphenyl ether |
| 2,3,7,8-tetrabromodibenzo-4-dioxin | An organobromine compound that is dibenzodioxine carrying four bromo substituents at positions 2, 3, 7 and 8. | 2,3,7,8-tetrabromodibenzodioxine |
| 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile | A pyrrole resulting from the N-dealkylation of the ethoxymethyl group of chlorfenapyr. It is the active insecticide of the proinsecticide chlorfenapyr. | tralopyril |
| 4-bromo-2-chlorophenol | A halophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by chlorine and bromine, respectively. | 4-bromo-2-chlorophenol |
| 4-bromophenyl phenyl ether | An aromatic ether that is diphenyl ether substituted at position 4 by a bromo group. | 4-bromophenyl phenyl ether |
| 5-bromo-4-chloro-3-indolyl beta-galactoside | An indolyl carbohydrate that is the beta-D-galactoside of 3-hydroxy-1H-indole in which the indole moiety is substituted at positions 4 and 5 by chlorine and bromine, respectively. It is used to test for the presence of an enzyme, beta-galactosidase, which cleaved the glycosidic bond to give 5-bromo-4-chloro-3-hydroxy-1H-indole, which immediately dimerises to give an intensely blue product. | 5-bromo-4-chloro-3-indolyl beta-D-galactoside |
| 5-bromo-4-chloro-3-indoxyl phosphate | An aryl phosphate that is indoxyl phopshate in which the indole moiety is substituted at positions 4 and 5 by chlorine and bromine, respectively. It is used to test for the presence of an enzyme, alkaline phosphatase, which cleaves the phosphate group to give 5-bromo-4-chloroindoxyl, which immediately dimerises to give an intensely blue product. | 5-bromo-4-chloro-3-indolyl phosphate |
| 5-bromouridine triphosphate | A pyrimidine ribonucleoside 5'-triphosphate having 5-bromouracil as the pyrimidine component. | 5-bromouridine 5'-triphosphate |
| 6-bromo-2-naphthol | A member of the class of naphthols that is 2-naphthol carrying an additional bromo substituent at position 6. | 6-bromo-2-naphthol |
| 6-bromo-2-naphthyl-beta-galactopyranoside | A beta-D-galactoside having a 6-bromo-2-naphthyl substituent at the anomeric position. | 6-bromo-2-naphthyl beta-D-galactoside |
| 6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene | | (+)-halomon |
| 8-bromo cyclic adenosine monophosphate | A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase. | 8-Br-cAMP |
| 8-bromo-2'-deoxyguanosine | An organobromine compound comprising 2'-deoxyguanosine having a bromo substituent at position 8 of the guanine ring system. | 8-bromo-2'-deoxyguanosine |
| 8-bromocyclic gmp | A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. | 8-bromo-3',5'-cyclic GMP |
| act-132577 | A member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. | ACT-132577 |
| ageladine a | An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis. | ageladine A |
| AZ3451 | A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (1S)-1-cyclohexylethyl, 6-bromo-1,3-benzodioxol-5-yl, and 4-(cyanoanilino)acyl groups at positions 1, 2 and 5, respectively. It is an allosteric modulator of protease-activated receptor 2 (IC50 = 23 nM) and exhibits anti-osteoarthritis properties. | AZ3451 |
| bde 183 | | 2,2',3,4,4',5',6-Heptabromodiphenyl ether |
| bedaquiline | A quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. | bedaquiline |
| bromacil | A pyrimidone that is pyrimidine-2,4(1H,3H)-dione substituted by a bromo group at position 5, a butan-2-yl group at position 3 and a methyl group at position 6. | 5-bromo-3-(butan-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione |
| bromcresol purple | A member of the class of 2,1-benzoxathioles that is 2,1-benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3-bromo-4-hydroxy-5-methylphenyl groups. A hydrophilic dye that is used as a pH indicator and to measure serum albumin concentrations. | bromocresol purple |
| bromfenac | Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure. | bromfenac |
| bromhexine | A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum). | bromhexine |
| bromisovalum | An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group. | 2-bromo-N-carbamoyl-3-methylbutanamide |
| bromoacetaldehyde | | 2-Bromoacetaldehyde |
| bromochlorodifluoromethane | A one-carbon compound that is methane in which the hydrogens have been replaced by two fluorines, a bromine, and a chlorine. Widely used in 'vapourising liquid'-type fire extinguishers, its use is now generally banned under the Montreal Protocol (ozone-depleting substances), although it is still used in certain applications (e.g. aviation). | bromochlorodifluoromethane |
| bromodiphenhydramine | A tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies. | bromazine |
| bromohydrin pyrophosphate | An alkyl diphosphate having bromohydrin as the alkyl group. | bromohydrin pyrophosphate |
| bromophycolide a | A diterpenoid that is a macrolide isolated from the Fijian red alga Callophycus serratus. It has been found to exhibit moderate cytotoxicity against several human tumour cell lines via specific apotopic cell death. It also displays anti-HIV, antibacterial, antifungal and antimalarial activity. | bromophycolide A |
| bromopyruvate | A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug | 3-bromo-2-oxopropanoic acid; 3-bromopyruvic acid |
| bromosuccinimide | A five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom. | N-bromosuccinimide |
| brompheniramine | Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. | brompheniramine |
| bromphenol blue | 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye. | bromophenol blue |
| bromthymol blue | A member of the class of 2,1-benzoxathioles that is 2,1-benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3-bromo-4-hydroxy-5-isopropyl-2-methylphenyl groups. | bromothymol blue |
| ceratamine a | An organic heterobicyclic compound, which is imidazo[4,5-d]azepin-5(6H)-one substituted by a 3,5-dibromo-4-methoxybenzyl group at position 4, a methyl group at position 6 and a methylamino group at position 2. It is an antimitotic alkaloid isolated from the marine sponge Pseudoceratina. | ceratamine A |
| chlorantranilipole | A carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes. | chlorantraniliprole |
| cincreasin | A member of the class of benzoxazoles that is 2-benzoxazolinone substituted at position 6 by a bromo group. | cincreasin |
| cyantraniliprole | A carboxamide that is chlorantraniliprole in which the chlorine atom attached to the phenyl ring has been replaced by a cyano group. A ryanodine receptor agonist, it is used as insecticide for the control of whitefly, thrips, aphids, fruitflies, and fruit worms in crops such as onions, potatoes and tomatoes. It is highly toxic to honeybees. | cyantraniliprole |
| decamethrin | A cyclopropanecarboxylate ester obtained by formal condensation between 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol. It is the active insecticide of the proinsecticide tralomethrin. | deltamethrin |
| dibromobimane | A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing two methyl substituents at positions 2 and 6 as well as two bromomethyl substituents at positions 3 and 5. | dibromobimane |
| dibromophakellin | An alkaloid isolated from the marine sponge Phakellia flabellata and Acanthella costata. It acts as an alpha2B adrenoceptor agonist. | (-)-dibromophakellin |
| eosine yellowish-(ys) | An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions. | eosin YS dye |
| eosine-5-isothiocyanate | The 2',4',5',7'-tetrabromo-5-isothiocyanato derivative of fluorescein; exhibits phosphorescence with an emission maximum at ~680 nm. | eosin 5-isothiocyanate |
| etravirine | An aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities | etravirine |
| gr 117289 | A member of the class of 1-benzofurans that is 3-bromo-1-benzofuran which is substituted by a 2-(1H-tetrazol-5-yl)phenyl group at position 2 and by a (2-butyl-5-carboxy-4-chloro-1H-imidazol-1-yl)methyl group at position 5. It is an angiotensin II receptor type 1 (AT1) antagonist and was in clinical trials for the treatment of hypertension (now discontinued). | zolasartan |
| halothane | A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position. | halothane |
| hexabromodiphenyl ether 154 | | 2,2',4,4',5,6'-Hexabromodiphenyl ether |
| jaspamide b | A cyclodepsipeptide isolated from Jaspis splendens. A derivative of jaspamide, it exhibits anti-tumour activity. | jaspamide B |
| laurinterol | A sesquiterpenoid isolated from Laurencia intermedia and Aplysia kurodai and has been found to exhibit antibacterial activity, | laurinterol |
| lesinurad | A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout. | lesinurad |
| liquid crystal polymer | A member of the class of oxolanes carrying 1,2,4-triazol-ylmethyl and 2,4-dichlorophenyl substituents at position 2 as well as a bromo substituent at position 4. A foliar applied conazole fungicide for a range of crops including cereals, fruit, vegetables and vines. | bromuconazole |
| lonafarnib | A benzocycloheptapyridine that is benzo[5,6]cyclohepta[1,2-b]pyridine which is substituted at positions 3 and 10 by bromines, at position 8 by chlorine, and at position 11 by an N-acetylpiperidin-4-yl group in which one of the hydrogens of the acetyl moiety has been replaced by a 1-carbamoylpiperidin-4-yl group. | 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide |
| macitentan | A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. | macitentan |
| massadine | An alkaloid isolated from Stylissa massa. | massadine |
| metrafenone | A member of the class of benzophenones that is benzophenone in which one of the phenyl groups is substituted by methoxy groups at positions 2, 3, and 4 and by a methyl group at position 6, while the other is substituted at positions 2, 3, and 6 by methyl, bromine, and methoxy groups, respectively. A fungicide with protectant and curative properties, it is used for the control of powdery mildew in cereals and grape vines. | metrafenone |
| mitobronitol | | Mitobronitol |
| mitolactol | | mitolactol |
| monobromobimane | A pyrazolopyrazole that consists of 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione bearing three methyl substituents at positions 2, 5 and 6 as well as a bromomethyl substituent at the 3-position. | monobromobimane |
| N-[1-(4-bromophenyl)ethyl]cyclobutanecarboxamide | | N-[1-(4-bromophenyl)ethyl]cyclobutanecarboxamide |
| naled | An dialkyl phosphate resulting from the formal condensation of the acidic hydroxy group of dimethyl hydrogen phosphate with the alcoholic hydroxy group of 1,2-dibromo-2,2-dichloroethanol. An organophosphate insecticide, it is no longer approved for use within the European Union. | naled |
| nsc 664704 | An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta). | kenpaullone |
| perflubron | A haloalkane that is perfluorooctane in which a fluorine attached to one of the terminal carbons has been replaced by a bromine. | perflubron |
| ph 797804 | A member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine. | PH 797804 |
| pipobroman | An N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. | pipobroman |
| pyrabactin | A sulfonamide obtained by formal condensation of the sulfo group of 4-bromonaphthalene-1-sulfonic acid with the exocyclic amino group of 2-pyridylmethylamine. Mimics the action of the abscisic acid, a phytohormone. | pyrabactin |
| SMER 28 | A member of the class of quinazolines that is quinazoline which is substituted by a prop-2-en-1-ylnitrilo group and a bromo group at positions 4 and 6, respectively. It is a modulator of mammalian autophagy. | SMER 28 |
| sulfobromophthalein | An organosulfonic acid that consists of phthalide bearing four bromo substituents at positions 4, 5, 6 and 7 as well as two 4-hydroxy-3-sulfophenyl groups both located at position 1. | bromosulfophthalein |
| tribromoethanol | | tribromoethanol |
| wiskostatin | A member of the class of carbazoles that is 1-(carbazol-9-yl)-3-(dimethylamino)propan-2-ol bearing two additional bromo substituents at positions 3 and 6 on the carbazole ring system. | 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol |
| zd 6474 | A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. | vandetanib |