ascorbic-acid and thiolactic-acid

ascorbic-acid has been researched along with thiolactic-acid* in 1 studies

Other Studies

1 other study(ies) available for ascorbic-acid and thiolactic-acid

Article	Year
Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins. Nucleic acids research, 1987, Nov-11, Volume: 15, Issue:21 Oligo-heptathymidylates covalently linked to porphyrins bind to complementary sequences and can induce local damages on the target molecule. In dark reactions, iron porphyrin derivatives exhibited various chemical reactivities resulting in base oxidation, crosslinking and chain scission reactions. Reactions induced by reductants, such as ascorbic acid, dithiothreitol or mercapto-propionic acid, led to very localised reactions. A single base was the target for more than 50% of the damages. Oxidising agents such as H2O2 and its alkyl derivatives induced reactions that extended to a wider range of altered bases. The specificity of the chemical modifications observed in these systems is discussed from a mechanistic point of view. Topics: Alkylating Agents; Aminacrine; Ascorbic Acid; Cross-Linking Reagents; Dithiothreitol; DNA Damage; Hydrogen Peroxide; Metalloporphyrins; NAD; Oxidation-Reduction; Poly T; Polydeoxyribonucleotides; Sulfhydryl Compounds	1987

Article

Year

Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins.

Nucleic acids research, 1987, Nov-11, Volume: 15, Issue:21

Oligo-heptathymidylates covalently linked to porphyrins bind to complementary sequences and can induce local damages on the target molecule. In dark reactions, iron porphyrin derivatives exhibited various chemical reactivities resulting in base oxidation, crosslinking and chain scission reactions. Reactions induced by reductants, such as ascorbic acid, dithiothreitol or mercapto-propionic acid, led to very localised reactions. A single base was the target for more than 50% of the damages. Oxidising agents such as H2O2 and its alkyl derivatives induced reactions that extended to a wider range of altered bases. The specificity of the chemical modifications observed in these systems is discussed from a mechanistic point of view.

Topics: Alkylating Agents; Aminacrine; Ascorbic Acid; Cross-Linking Reagents; Dithiothreitol; DNA Damage; Hydrogen Peroxide; Metalloporphyrins; NAD; Oxidation-Reduction; Poly T; Polydeoxyribonucleotides; Sulfhydryl Compounds

1987