Roles > plasticiser
Page last updated: 2024-08-05 15:18:00

plasticiser

Any compound that is used as an additive to increase the plasticity or fluidity of a substance, particularly but not exclusively to synthetic polymers.

ChEBI ID: 79056

Members (11)

MemberDefinitionClass
dehydroacetic acidA pyran-2,4-dione substituted at position 3 by an acetyl group and at position 6 by a methyl group. A fungicide and bactericide it is used primarily in processed fruit and vegetables.dehydroacetic acid
di-n-pentyl phthalateA phthalate ester that is the dipentyl ester of benzene-1,2-dicarboxylic acid.dipentyl phthalate
dibutyl phthalateA phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.dibutyl phthalate
diethyl phthalateThe diethyl ester of benzene-1,2-dicarboxylic acid.diethyl phthalate
diethylhexyl phthalateA phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.bis(2-ethylhexyl) phthalate
diethylhexyladipateA diester resulting from the formal condensation of the carboxy groups of adipic acid with 2-ethylhexan-1-ol. It is used as a plasticiser in the preparation of various polymers.bis(2-ethylhexyl) adipate
diisobutyl phthalateA phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of isobutanol.diisobutyl phthalate
diisononyl phthalateThe diisononyl ester of benzene-1,2-dicarboxylic acid.diisononyl phthalate
polyethylene glycol monostearateAn octadecanoate ester obtained by formal condensation between the carboxy group of octadecanoic (stearic) acid and one of the hydroxy groups of ethylene glycol. It is an ingredient in many personal care products and cosmetics.2-hydroxyethyl octadecanoate
triethylene glycolA poly(ethylene glycol) that is octane-1,8-diol in which the carbon atoms at positions 3 and 6 have been replaced by oxygen atoms.triethylene glycol
triphenyl phosphateAn aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol.triphenyl phosphate

Research

Studies (5,247)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990666 (12.69)18.7374
1990's411 (7.83)18.2507
2000's964 (18.37)29.6817
2010's1,899 (36.19)24.3611
2020's1,307 (24.91)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials46 (0.74%)5.53%
Reviews250 (4.04%)6.00%
Case Studies28 (0.45%)4.05%
Observational2 (0.03%)0.25%
Other5,857 (94.73%)84.16%

Protein Targets (87)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency10.000011
acetylcholinesteraseHomo sapiens (human)Potency21.333548
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.099012
AR proteinHomo sapiens (human)Potency25.27901031
aryl hydrocarbon receptorHomo sapiens (human)Potency76.958811
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency47.900314
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency44.910611
caspase-3Homo sapiens (human)Potency44.910611
Cellular tumor antigen p53Homo sapiens (human)Potency42.561014
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency0.007911
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency58.345414
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency38.093412
chromobox protein homolog 1Homo sapiens (human)Potency72.091815
cytochrome P450 2C9, partialHomo sapiens (human)Potency22.333212
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency16.130326
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency6.326111
estrogen nuclear receptor alphaHomo sapiens (human)Potency34.0452825
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency27.326724
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency27.5097617
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency31.622811
farnesoid X nuclear receptorHomo sapiens (human)Potency30.436535
GVesicular stomatitis virusPotency22.333212
GABA theta subunitRattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency16.130313
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency16.130313
gemininHomo sapiens (human)Potency0.302324
GLI family zinc finger 3Homo sapiens (human)Potency19.937829
glp-1 receptor, partialHomo sapiens (human)Potency28.183812
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency11.436445
Guanine nucleotide-binding protein GHomo sapiens (human)Potency11.220211
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency22.333212
IDH1Homo sapiens (human)Potency1.835611
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency22.333214
Integrin alpha-IIbHomo sapiens (human)Potency0.007911
Integrin beta-3Homo sapiens (human)Potency0.007911
Interferon betaHomo sapiens (human)Potency22.333212
interleukin 8Homo sapiens (human)Potency79.552312
lethal factor (plasmid)Bacillus anthracis str. A2012Potency7.943311
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency28.183812
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.810711
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency40.8267410
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency29.114313
Nuclear receptor ROR-gammaHomo sapiens (human)Potency28.989513
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency30.0916316
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency28.183811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency37.981747
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency20.094124
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency51.574913
pregnane X nuclear receptorHomo sapiens (human)Potency35.725029
pregnane X receptorRattus norvegicus (Norway rat)Potency25.515412
progesterone receptorHomo sapiens (human)Potency49.310727
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency35.716812
RAR-related orphan receptor gammaMus musculus (house mouse)Potency27.524826
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency31.289438
retinoid X nuclear receptor alphaHomo sapiens (human)Potency30.5241313
serine-protein kinase ATM isoform aHomo sapiens (human)Potency25.118911
SMAD family member 2Homo sapiens (human)Potency21.875111
SMAD family member 3Homo sapiens (human)Potency21.875111
Smad3Homo sapiens (human)Potency35.481311
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency35.481311
TAR DNA-binding protein 43Homo sapiens (human)Potency0.398111
TDP1 proteinHomo sapiens (human)Potency13.450423
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency42.184535
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.214023
thyroid stimulating hormone receptorHomo sapiens (human)Potency20.7711419
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency77.037922
USP1 protein, partialHomo sapiens (human)Potency50.118711
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency35.3658210
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency19.473238

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cathepsin BHomo sapiens (human)IC50420.000011
Cathepsin BMus musculus (house mouse)IC50230.000011
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)IC5055.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ORF73Human gammaherpesvirus 8EC5075.000011