ascorbic-acid and Spastic-Paraplegia--Hereditary

Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hereditary spastic paraparesis (HSP) patients. The results showed that plasma SOD, vitamin E and nitric oxide levels were significantly low in HSP patients. These findings indicate the influence of oxidative damage in the degenerative process of HSP.

Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Child, Preschool; Female; Free Radical Scavengers; Free Radicals; Humans; Infant; Male; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Paraparesis, Spastic; Severity of Illness Index; Spastic Paraplegia, Hereditary; Superoxide Dismutase; Vitamin E