| Member | Definition | Class |
|---|
| bicuculline | A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. | bicuculline |
| chlordan | | chlordane |
| endosulfan | A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10. | endosulfan |
| heptachlor | A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations. | heptachlor |
| suramin | A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. | suramin |
| suramin sodium | An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. | suramin sodium |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 55.3991 | 2 | 10 |
| AR protein | Homo sapiens (human) | Potency | 55.9906 | 8 | 33 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 7.0795 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 72.7134 | 1 | 4 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 71.9424 | 1 | 5 |
| caspase-3 | Homo sapiens (human) | Potency | 72.7134 | 1 | 4 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 71.9424 | 1 | 5 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.3844 | 2 | 11 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.5870 | 3 | 5 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 17.9008 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.5331 | 2 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 22.1067 | 3 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 4.9213 | 2 | 6 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.5331 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 11.0524 | 2 | 8 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 61.7137 | 1 | 6 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 50.7062 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 0.0658 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 9.2961 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 50.7983 | 11 | 35 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 53.0539 | 3 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 52.0817 | 6 | 31 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 9.2634 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 10.4760 | 2 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 50.2786 | 5 | 18 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| galactokinase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 11.0524 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 38.5052 | 3 | 14 |
| GLS protein | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 51.9627 | 4 | 18 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 38.7162 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 51.2178 | 2 | 12 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.1623 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 95.9611 | 2 | 12 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 11.0344 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 50.3473 | 2 | 11 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 34.8705 | 3 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 45.1969 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.9648 | 2 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 22.4748 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.5362 | 2 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.1822 | 2 | 6 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.3548 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 50.2048 | 3 | 14 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 55.6299 | 2 | 11 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 19.8198 | 1 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.2276 | 2 | 7 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 36.1254 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.6840 | 4 | 7 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 38.1456 | 1 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 49.3832 | 4 | 10 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 54.5388 | 1 | 2 |
| Platelet-activating factor receptor | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 31.7626 | 1 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.1631 | 2 | 7 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 44.6684 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 36.4818 | 2 | 9 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 0.7943 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 51.8902 | 2 | 11 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0075 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 57.9946 | 3 | 16 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 30.8995 | 4 | 11 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 56.3183 | 2 | 5 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 56.3183 | 2 | 5 |
| snurportin-1 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.3095 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 40.1304 | 1 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 41.4940 | 3 | 13 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 50.1187 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.8791 | 5 | 18 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 40.8502 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 33.6724 | 2 | 12 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 55.3630 | 4 | 8 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 68.5199 | 1 | 1 |