Page last updated: 2024-08-05 15:26:30
food component
A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
ChEBI ID: 78295
Members (12)
| Member | Definition | Class |
|---|---|---|
| 7-hydroxycoumarin | A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. | umbelliferone |
| beta-tocopherol | A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 5 and 8. While it is found in low concentrations in many vegetable oils, only cottonseed oil contains significant amounts. | beta-tocopherol |
| chlorogenic acid | A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is an intermediate metabolite in the biosynthesis of lignin. | chlorogenic acid |
| elaidic acid | A 9-octadecenoic acid and the trans-isomer of oleic acid. | elaidic acid |
| gallocatechol | A flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration. | (-)-epigallocatechin |
| myricetin | A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7. It has been isolated from the leaves of Myrica rubra and other plants. | myricetin |
| pentadecanoic acid | A straight-chain saturated fatty acid containing fifteen-carbon atoms. | pentadecanoic acid |
| piperine | A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. | piperine |
| stachydrine | An amino acid betaine that is L-proline zwitterion in which both of the hydrogens attached to the nitrogen are replaced by methyl groups. | L-proline betaine |
| theobromine | A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator. | theobromine |
| trans-4-coumaric acid | The trans-isomer of 4-coumaric acid. | trans-4-coumaric acid |
| trigonelline | An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group. | N-methylnicotinate |
Research
Studies (8,780)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,375 (15.66) | 18.7374 |
| 1990's | 646 (7.36) | 18.2507 |
| 2000's | 1,529 (17.41) | 29.6817 |
| 2010's | 3,616 (41.18) | 24.3611 |
| 2020's | 1,614 (18.38) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 337 (3.62%) | 5.53% |
| Reviews | 330 (3.55%) | 6.00% |
| Case Studies | 50 (0.54%) | 4.05% |
| Observational | 3 (0.03%) | 0.25% |
| Other | 8,587 (92.26%) | 84.16% |
Protein Targets (332)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 14.9131 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 2.2029 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 12.5893 | 1 | 2 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 18.6089 | 1 | 5 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 35.4813 | 2 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 20.3510 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 13.3010 | 7 | 15 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 4.1740 | 3 | 5 |
| arylsulfatase A | Homo sapiens (human) | Potency | 12.0095 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.9479 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 14.8436 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.8108 | 4 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 11.8237 | 2 | 3 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 13.5110 | 2 | 5 |
| BRCA1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.7291 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 11.9613 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 2.1648 | 2 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 31.6534 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 24.4413 | 2 | 5 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 10.7890 | 2 | 8 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 10.6654 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.2718 | 3 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.0619 | 1 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 10.2227 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 10.7890 | 2 | 8 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 41.1749 | 2 | 6 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 11.3112 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 10.8631 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 37.9083 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.5804 | 2 | 11 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 11.9877 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 1.3522 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 16.4816 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 6.9241 | 1 | 2 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 1.2204 | 2 | 3 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 15.0030 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 19.4003 | 2 | 7 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 1.1884 | 2 | 9 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.6226 | 8 | 14 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 61.2549 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 10.0437 | 6 | 12 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.4840 | 1 | 8 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.9566 | 4 | 6 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 51.5795 | 2 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 14.0720 | 3 | 8 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 10.6840 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.3311 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 11.9302 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 2.2886 | 3 | 5 |
| GLS protein | Homo sapiens (human) | Potency | 17.6655 | 2 | 5 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.0378 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 3.2583 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.1196 | 2 | 15 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 9.3852 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 63.3756 | 2 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 35.7250 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.9953 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.6840 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 0.3982 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 7.1369 | 1 | 3 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 0.2984 | 2 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 29.8435 | 3 | 6 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 7.3732 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 10.2179 | 2 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.9073 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0112 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 27.4041 | 3 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 5.6234 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 7.9328 | 3 | 7 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 42.6703 | 2 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 48.8311 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.0176 | 3 | 3 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 2.0585 | 3 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 1.4831 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 5.5610 | 1 | 2 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 1.5044 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 16.6491 | 2 | 3 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 57.8620 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 1.9953 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 24.3616 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 5.0150 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 10.3882 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 3.0975 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 30.4646 | 3 | 5 |
| RGS12 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 19.8812 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 9.4662 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 35.4813 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 28.8453 | 2 | 11 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 21.6794 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 32.0624 | 3 | 10 |
| Thrombopoietin | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 62.2781 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 47.4953 | 2 | 3 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 6.3534 | 2 | 3 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.5610 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.5610 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 36.6814 | 1 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 1.3476 | 1 | 2 |
| Vpr | Human immunodeficiency virus 1 | Potency | 63.0957 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 1.5000 | 1 | 1 |
| 1,3-beta-D-glucan synthase catalytic subunit | Candida albicans | IC50 | 90.0000 | 1 | 1 |
| 2-5A-dependent ribonuclease | Homo sapiens (human) | IC50 | 264.0000 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 14.0000 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 140.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 14,550.0000 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 37.8000 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 233.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 31.8625 | 4 | 4 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 152.3820 | 4 | 5 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 250.0000 | 2 | 3 |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | Homo sapiens (human) | IC50 | 24.8000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 26.0000 | 4 | 5 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 15.4750 | 2 | 2 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | IC50 | 35.4500 | 1 | 2 |
| Aldo-keto reductase family 1 member C21 | Mus musculus (house mouse) | IC50 | 12.3000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 33.2000 | 1 | 1 |
| Alpha-amylase 1A | Homo sapiens (human) | IC50 | 30.2000 | 2 | 2 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 90.8000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 8.0400 | 2 | 3 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 58.9800 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Mus musculus (house mouse) | Ki | 19.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 0.7665 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Mus musculus (house mouse) | Ki | 3.1900 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 20.2875 | 8 | 8 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Anthrax toxin receptor 2 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 2 |
| Apoptosis regulator Bcl-2 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Arginase | Leishmania amazonensis | IC50 | 2.1000 | 1 | 1 |
| Arginase | Leishmania amazonensis | Ki | 1.2000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 44.8000 | 2 | 2 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 3.9800 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 1.7300 | 1 | 3 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 168.9933 | 3 | 3 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 35.7000 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 361.3000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 31,000.0000 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 212.6587 | 6 | 8 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 3.5138 | 5 | 5 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 10.1000 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 6.6800 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 31,000.0000 | 1 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 228.2475 | 6 | 8 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 1.7300 | 1 | 3 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 7.5700 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 9.6000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 5.9600 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 7.7600 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 6.7200 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 5.2300 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 1.3590 | 5 | 5 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 0.9400 | 3 | 3 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 0.9400 | 3 | 3 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 0.9400 | 3 | 3 |
| Cationic trypsin | Bos taurus (cattle) | IC50 | 10.2000 | 1 | 1 |
| Chain A, Pancreatic alpha-amylase | Homo sapiens (human) | Ki | 110.0000 | 1 | 2 |
| Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1 | Homo sapiens (human) | IC50 | 0.7800 | 1 | 4 |
| Cholinesterase | Equus caballus (horse) | IC50 | 500.0000 | 1 | 1 |
| Cystathionine beta-synthase | Homo sapiens (human) | IC50 | 18.8000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.3700 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0270 | 2 | 2 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 257.4300 | 1 | 4 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 0.8800 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3A isoform a | Homo sapiens (human) | IC50 | 17.5000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 2.3900 | 1 | 1 |
| DNA primase TraC | Escherichia coli | IC50 | 700.0000 | 1 | 1 |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | IC50 | 2.9800 | 5 | 5 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | IC50 | 0.3200 | 2 | 2 |
| ELAV-like protein 3 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | Escherichia coli K-12 | IC50 | 100.0000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 3.7000 | 2 | 2 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 1.9225 | 3 | 3 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | Ki | 1,000.0000 | 2 | 2 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 2.1200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | Ki | 0.0130 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | Ki | 0.0130 | 1 | 1 |
| Genome polyprotein | Hepatitis C virus (isolate BK) | IC50 | 36.6000 | 1 | 1 |
| Genome polyprotein | Zika virus | IC50 | 11.6500 | 2 | 2 |
| Genome polyprotein | Zika virus | Ki | 0.8000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Saccharomyces cerevisiae S288C | IC50 | 1,000.0000 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 616.5950 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | Trypanosoma cruzi | IC50 | 616.5800 | 1 | 1 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | IC50 | 13.5000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 11 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 3 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 4 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 5 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 6 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 7 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Histone deacetylase 9 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | IC50 | 21.0400 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | Ki | 3.8100 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Insulin receptor | Homo sapiens (human) | Ki | 2.6000 | 1 | 1 |
| Insulin-degrading enzyme | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 36.9400 | 8 | 10 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 0.9489 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 2.9200 | 1 | 1 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 12.5000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 1.5000 | 3 | 3 |
| large T antigen | Betapolyomavirus macacae | IC50 | 16.7800 | 1 | 2 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 0.9489 | 2 | 2 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 2.1000 | 2 | 2 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 1.9400 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 1.9400 | 1 | 2 |
| MO15-related protein kinase Pfmrk | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 157.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 7.8500 | 2 | 2 |
| Myosin light chain kinase, smooth muscle | Homo sapiens (human) | Ki | 1.7000 | 1 | 1 |
| NAD kinase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 68.0667 | 3 | 3 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 3.2600 | 2 | 2 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 258.3333 | 3 | 3 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,364.9500 | 4 | 4 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 54.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 500.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 500.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 407.3333 | 3 | 3 |
| Protein E6 | Human papillomavirus 16 | IC50 | 0.8500 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 1.6900 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 13.3667 | 2 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 39.4800 | 1 | 1 |
| Ribonuclease HI | Escherichia coli K-12 | IC50 | 20.0000 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 43.0000 | 1 | 1 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 1.5620 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 0.7800 | 2 | 2 |
| Short transient receptor potential channel 5 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 2 | Homo sapiens (human) | IC50 | 12.0000 | 2 | 2 |
| Solute carrier family 2, facilitated glucose transporter member 4 | Rattus norvegicus (Norway rat) | Ki | 33.5000 | 1 | 1 |
| Sorbitol dehydrogenase | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 82.6000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 82.6000 | 1 | 1 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 100.5000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 106.7500 | 4 | 4 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| Tyrosine-protein kinase transforming protein Fps | Fujinami sarcoma virus | Ki | 1.8000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 59.8667 | 3 | 3 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 4,107.5500 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 2 | Homo sapiens (human) | IC50 | 77.9000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 6.8000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 112.7933 | 2 | 3 |
| Zn finger protein | Nicotiana tabacum (common tobacco) | Ki | 0.7540 | 1 | 1 |
Activation Measurements
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease | Homo sapiens (human) | Activity | 30.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Kinact | 58.4000 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Kinact | 0.7540 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 100.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 0.4820 | 1 | 1 |
| Caspase 6, apoptosis-related cysteine peptidase | Homo sapiens (human) | AC50 | 0.4610 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | AC50 | 5.4000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ke | 1.9900 | 1 | 1 |
| dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | AC50 | 10.8520 | 1 | 1 |
| ERAP1 protein | Homo sapiens (human) | AC50 | 12.1400 | 1 | 1 |
| fibroblast growth factor 22 isoform 1 precursor | Homo sapiens (human) | AbsAC1_uM | 4.3700 | 1 | 1 |
| glycogen synthase kinase-3 alpha | Homo sapiens (human) | AC50 | 4.1330 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ke | 0.2500 | 1 | 1 |
| Lactoperoxidase | Bos taurus (cattle) | Km | 0.7900 | 1 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | Ke | 0.3000 | 1 | 1 |
| Quinone oxidoreductase | Mus musculus (house mouse) | CD | 500.0000 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | -Log IC50 | 0.1100 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | CD | 500.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Activity | 10.0000 | 1 | 1 |