| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1660315 | Antiinflammatory activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in IL17 mRNA level at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by RT-qPCR analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID654853 | Binding affinity to calf thymus DNA assessed as change in melting temperature by thermal denaturation assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID1326317 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1778654 | Antibacterial activity against penicillin-resistant Staphylococcus epidermidis assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1390874 | Inhibition of mitochondrial respiratory complex 1 in differentiated Sprague-Dawley rat L6 myotube cells assessed as mitochondrial membrane potential at 10 uM after 40 to 60 mins by JC-1 staining based fluorescence assay (Rvb = 100 +/- 1.6%) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID595329 | Growth inhibition against human SKN cells after 72 hrs by MTT assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1138616 | Cmax in human plasma assessed as demethyleneberberin at 500 mg, po by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1654977 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as reduction in Cdc2 protein expression at 100 mg/kg, ig dosed daily for 15 days by Western blot analysis | | | |
| AID723036 | Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 1 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 0.51%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1778643 | Antibacterial activity against penicillin-susceptible Bacillus subtilis ATCC 9372 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1660254 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in DSS-induced colon shortening at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1744518 | Binding affinity to NEK7 in PMA-differentiated human THP-1 cells assessed as reduction in Cy3-labeled target proteins at 100 uM incubated for 8 hrs using probe-16 by fluorescent gel imaging analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1678081 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as increase in cecum weight at 50 mg/kg administrated for 14 days | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1660290 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in DSS-induced loss of colon crypt and columnar epithelium at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-c | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1138601 | Solubility of the compound in sodium phosphate buffer at pH 8.6 at 25 degC after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1654948 | Activation of RXRalpha (unknown origin) expressed in human KM12C cells co-expressing beta-catenin and c-Cbl assessed as induction of beta-caten interaction with c-Cbl at 25 to 50 uM incubated for 15 hrs by mammalian two-hybrid assay | | | |
| AID1571757 | Aqueous solubility of compound | 2019 | MedChemComm, Apr-01, Volume: 10, Issue:4
| Novel carbohydrate modified berberine derivatives: synthesis and |
| AID546775 | Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as accumulation of Berberine at 3 uM by fluorescence assay in presence of INF55 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID300285 | Binding affinity to human telo21 G-quadruplex DNA assessed as thermal stability in tris-HCl buffer at pH 7.4 | 2007 | Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
| 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. |
| AID758164 | Antibacterial activity against Escherichia coli DH52 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1655009 | Bioavailability in Sprague-Dawley rat at 100 mg/kg, ig measured after 0.083 to 36 hrs by LC-MS/MS analysis | | | |
| AID361587 | Upregulation of LDLR mRNA expression in human HepG2 cells after 8 hrs by RT-PCR relative to control | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16
| Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators. |
| AID1390871 | Upregulation of AMPKalpha phosphorylation at Thr172 residues in Sprague-Dawley rat L6 myotube cells at 10 uM after 1 hr by Western blot analysis | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID1660264 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in stool bleeding at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge measured on day 38 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1724011 | Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Identification of the first noncompetitive SARM1 inhibitors. |
| AID269174 | Antifungal activity against Candida lusitaniae ATCC 42720 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1503066 | Inhibition of glucose production in Sprague-Dawley rat primary hepatocytes grown under gluconeogenic medium assessed as glucose production level at 5 uM incubated for 6 hrs by glucose assay reagent based glucose oxidase method (Rvb = 100%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID723287 | Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 0.25 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 0.51%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID238104 | In vitro association constant for binding at d(AAGAATTCTT)2 done in 50 mM Tris-HCL in pH 6.35 at room temperature | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
| Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities. |
| AID723037 | Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 0.5 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 3.16%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID361482 | Antibacterial activity against NorA knockout Staphylococcus aureus K1758 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus. |
| AID1654984 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as effect on Ki67 protein expression at 100 mg/kg, ig dosed daily for 15 days by immunohistochemistry analysis | | | |
| AID588974 | Substrates of transporters of clinical importance in the absorption and disposition of drugs, MDR1 | 2010 | Nature reviews. Drug discovery, Mar, Volume: 9, Issue:3
| Membrane transporters in drug development. |
| AID697843 | Inhibition of HFIP-induced amyloid beta (1 to 40) aggregation at 20 uM after 45 mins by thioflavin T fluorescence method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1744508 | Toxicity in mouse BMDM cells assessed as induction of apoptosis by measuring cleaved caspase-7 levels up to 40 uM incubated for 24 hrs by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID590167 | Therapeutic index, ratio of CC50 for human CEM cells expressing green fluorescent protein to EC50 for Human immunodeficiency virus 1 NL4.3 | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. |
| AID1744524 | Binding affinity to purified recombinant human NEK7 by SPR analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1678067 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as promoted regeneration of intestinal mucosa at 50 mg/kg administrated for 14 days by H and E staining analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1846554 | Antiproliferative activity against mouse CCRF S-180 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID1778648 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis ATCC19434 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID269173 | Antifungal activity against Candida tropicalis ATCC 13803 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1681589 | Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID378023 | Toxicity in brine shrimp | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Neovibsanin F and its congeners, rearranged vibsane-type diterpenes from Viburnum suspensum. |
| AID1138607 | 1-Octanol-water partition coefficient, log P of the compound at pH 6 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1138613 | Binding affinity to bovine serum albumin by fluorescence quenching assay | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID402386 | Antimicrobial activity against recombinant Mycobacterium intracellular expressing pMV361 lux after 3 days by luciferase assay | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID1681592 | Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1654960 | Activation of RXRalpha in human HCT116 cells assessed as reduction in c-Myc mRNA expression at 30 to 60 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID1654968 | Activation of RXRalpha in human SW620 cells assessed as reduction in crease in p21 (WAF1/CIP1) mRNA expression at 40 to 80 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID346761 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID590347 | Inhibition of Human immunodeficiency virus 1 NL4.3 reverse transcriptase activity | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. |
| AID238105 | In vitro association constant for binding at d(TA AGAATTCTTA)2 done in 50 mM Tris-HCL in pH 6.35 at room temperature | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
| Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities. |
| AID346763 | Induction of HMG-CoA reductase mRNA expression in hyperlipidemic Sprague-Dawley rat liver at 100 mg/kg, po daily twice for 30 days by RT-PCR | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1654979 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as increase in p21 (WAF1/CIP) protein expression at 100 mg/kg, ig dosed daily for 15 days by Western blot analysis | | | |
| AID1654954 | Activation of RXRalpha in human KM12C cells assessed as reduction in c-Myc mRNA expression at 25 to 50 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID546773 | Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as accumulation of compound at 3 uM by fluorescence assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID346786 | Elimination half life in po dosed human | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID654859 | Binding affinity to calf thymus DNA in citrate-phosphate buffer at pH 7 by isothermal titration calorimetry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID1193495 | Thermodynamic equilibrium solubility, log S of the compound in simulated intestinal fluid at pH 6.8 at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID136551 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 160 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID1678070 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in TNF-alpha mRNA expression in colon tissue at 50 mg/kg administrated for 14 days by RT-qPCR analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1678076 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in MPO activity in colon tissue at 50 mg/kg administrated for 14 days by colorimetric method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID486996 | Selectivity ratio of IC50 for equine serum BuChE to IC50 for electric eel AChE | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. |
| AID1678072 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in IL-6 mRNA expression in colon tissue at 50 mg/kg administrated for 14 days by RT-qPCR analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID487442 | Induction of apoptosis in human HL60 cells after 48 hrs using annexin V-propidium iodide staining by FACS analysis | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones. |
| AID1484410 | Antibacterial activity against Bacillus subtilis 168 after 18 hrs by Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID300288 | Inhibition of amplification in human telo21 G-quadruplex DNA by PCR stop assay | 2007 | Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
| 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. |
| AID758161 | Antifungal activity against Candida albicans after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1681644 | Induction of morphological changes in human HepG2 cells assessed as accumulation of cytoplasmic vacuoles at 40 uM after 24 hrs by optical microscopic method | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1654925 | Inhibition of cell proliferation of human HCT116 cells incubated for 15 hrs by MTT assay | | | |
| AID697831 | Inhibition of electric eel AChE by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID572147 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomeganorM plasmid containing Neisseria gonorrhoeae multidrug efflux pump NorM after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID346762 | Induction of LDLR mRNA expression in hyperlipidemic Sprague-Dawley rat liver at 100 mg/kg, po daily twice for 30 days by RT-PCR relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1628118 | Displacement of bis-ANS from Escherichia coli FtsZ | 2016 | Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
| Targeting the Bacterial Division Protein FtsZ. |
| AID595336 | Downregulation of Impk mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID501768 | Hypolipidemic activity in high fat high cholesterol diet fed Wistar rat hyperlipidemic model assessed as reduction in total cholesterol 100 mg/kg, po qd for 28 days | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17
| Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. |
| AID1654942 | Activation of RXRalpha in human KM12C cells assessed as induction of beta-catenin protein degradation at 25 to 50 uM incubated for 15 hrs by Western blot analysis | | | |
| AID300286 | Binding affinity to human telo21 G-quadruplex DNA assessed as change in thermal stability in tris-HCl buffer at pH 7.4 | 2007 | Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
| 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. |
| AID1655004 | Half life in Sprague-Dawley rat at 100 mg/kg, ig measured after 0.083 to 36 hrs by LC-MS/MS analysis | | | |
| AID1484414 | Antibacterial activity against Escherichia coli ATCC BAA2108 expressing NDM-1 beta-lactamase after 18 hrs by Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID293739 | Inhibition of HCMV penetration to MRC5 cells at 0.2 to 2 uM | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1678088 | Antibacterial activity against Escherichia coli 44113-5 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1138617 | Cmax in human plasma assessed as jatrorrhizine at 500 mg, po by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID437568 | Inhibition of Rac1b GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. |
| AID375858 | Binding affinity to G-quadruplex HTG21 oligomer by fluorescence titration experiment | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands. |
| AID1138615 | Tmax in human at 500 mg, po by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID293736 | Inhibition of HCMV proliferation in MRC5 cells after 54 hrs post-infection at 10 uM by plaque assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1660245 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in stool consistency scores at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS challenge and measured on day | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1390875 | Inhibition of mitochondrial respiratory complex 1 in differentiated Sprague-Dawley rat L6 myotube cells assessed as mitochondrial membrane potential at 20 uM after 40 to 60 mins by JC-1 staining based fluorescence assay (Rvb = 100 +/- 1.6%) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID456912 | Non-competitive inhibition of horse serum BChE by Lineweaver-Burke plot | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID346758 | Reduction of blood cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice for 30 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1744546 | Antiinflammatory activity in NEK7 wild type C57BL/6 mouse model assessed as reduction in lesion in spleen in at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by H and E staining | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1138618 | Tmax in human assessed as demethyleneberberin at 500 mg, po by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID456910 | Non-competitive inhibition of electric eel AChE by Lineweaver-Burke plot | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID1628114 | Inhibition of Escherichia coli FtsZ assessed as reduction in GTPase activity by malachite green assay | 2016 | Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
| Targeting the Bacterial Division Protein FtsZ. |
| AID1744504 | Inhibition of LPS + nigericin-induced IL-1beta secretion in PMA-differentiated human THP-1 cells incubated for 1 to 24 hrs by Immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1628113 | Inhibition of Escherichia coli FtsZ assessed as reduction in polymerization | 2016 | Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
| Targeting the Bacterial Division Protein FtsZ. |
| AID419863 | Antibacterial activity against Staphylococcus aureus K2378 overexpressing NorA efflux pump after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID377676 | Antifungal activity against Candida shehatae after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID501764 | Lipophilicity, log P of the compound | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17
| Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. |
| AID419861 | Antibacterial activity against Staphylococcus aureus K1758 NorA efflux pump-deficient mutant after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID300289 | Inhibition of telomerase expressed in MCF7 cells by TRAP assay | 2007 | Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
| 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. |
| AID1654985 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as increase in p21 (WAF1/CIP) protein expression at 100 mg/kg, ig dosed daily for 15 days by immunohistochemistry analysis | | | |
| AID1724009 | Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed as EADPR formation using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Identification of the first noncompetitive SARM1 inhibitors. |
| AID658162 | Stabilization of human G-quadruplex F21T assessed as change in melting temperature at 1 uM by FRET assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. |
| AID697853 | Inhibition of horse BChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1138626 | Hypolipidemic activity in hypercholesterolemic patient assessed as reduction of total cholesterol level at 15 mg/kg/day administered for 3 months measured every month during compound treatment | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID595327 | Growth inhibition against rat A10 cells after 72 hrs by MTT assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1660334 | Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced IL6 mRNA level at 1 uM incubated for 1 hr followed by LPS challenge and measured after 4 to 6 hrs by q-PCR method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1703573 | Inhibition of recombinant human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured at 2 mins interval by Ellman's method | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID378593 | Cytotoxicity against human KB cells after 72 hrs | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID1628384 | Antimicrobial activity against Bacillus proteus ATCC13315 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID346774 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic C57BL/6J mouse at 100 mg/kg, po daily twice for 21 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1724007 | Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate at 25 uM preincubated for 20 mins followed by ENAD addition and measured after 1 hr relative to control | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Identification of the first noncompetitive SARM1 inhibitors. |
| AID1678073 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in IL-1beta protein expression in colon tissue at 50 mg/kg administrated for 14 days by Western blot analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1678087 | Antibacterial activity against Typhoid bacillus 50071-16 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1703583 | Inhibition of recombinant human His-tagged Prolyl oligopeptidase expressed in Escherichia coli expression system preincubated with enzyme for 15 mins followed by addition of ZGP-AMC substrate measured after 1 hr by fluorescence assay | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1138620 | Cmax in human plasma assessed as berberrubine at 500 mg, po after 4 hrs by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1470625 | Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents. |
| AID1503067 | Inhibition of glucose production in Sprague-Dawley rat primary hepatocytes grown under gluconeogenic medium assessed as glucose production level at 10 uM incubated for 6 hrs by glucose assay reagent based glucose oxidase method (Rvb = 100%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1744538 | Inhibition of AIM2-induced IL-1beta activation in human THP-1 cells at 10 uM pre-treatment for 2 hrs before AIM2 addition | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1681587 | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1744543 | Antiinflammatory activity in NEK7 wild type C57BL/6 mouse model assessed as reduction in lesion in heart in at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by H and E staining | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1503127 | Inhibition of human ERG by patch clamp assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1778646 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes clinical isolate 1 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID546786 | Cellular uptake in NorA-deficient Staphylococcus aureus K1758 assessed as accumulation of compound at 3 uM by fluorescence assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID439080 | Upregulation of InsR mRNA expression in human liver HepG2 at 10 ug/mL after 8 hrs by RT-PCR relative to control | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. |
| AID1628391 | Antimicrobial activity against beer yeast ATCC 9763 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1628392 | Antimicrobial activity against Candida albicans ATCC 76615 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1484411 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by cation adjusted Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID377674 | Antifungal activity against azole-resistant Candida albicans CN1A after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID1678083 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as colon weight at 50 mg/kg administrated for 14 days (Rvb = 0.369 +/- 0.023 g) | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1654978 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as reduction in c-Myc protein expression at 100 mg/kg, ig dosed daily for 15 days by Western blot analysis | | | |
| AID594453 | Thermal stability of c-MYC FPu18T G-quadruplex DNA assessed as stabilization temperature at 2 uM by FRET assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene. |
| AID439079 | Upregulation of LDLR mRNA expression in human liver HepG2 at 10 ug/mL after 8 hrs by RT-PCR relative to control | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. |
| AID293738 | Inhibition of HCMV adsorption to MRC5 cells at 0.2 to 2 uM by infectious centre assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1681586 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1266805 | Inhibition of Staphylococcus aureus ATCC 6538p sortase A expressed in Escherichia coli using dabcyl-QALPETGEE-edans as substrate incubated for 1 hr by fluorescence spectrophotometry analysis | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11
| Meroterpenoids from a Tropical Dysidea sp. Sponge. |
| AID537736 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1646885 | Induction of cell morphological changes in human PC3 cells assessed as cytoplasmic vacuolization at 50 uM measured after 24 hrs by white light microscopy | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID635416 | Selectivity ratio of IC50 for equine serum BuChE to IC50 for electric eel AChE | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. |
| AID1503065 | Stimulation of glucose consumption in rat L6 cells at 10 uM incubated for 12 hrs by glucose assay reagent based glucose oxidase method relative to untreated control | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID269178 | Antifungal activity against Cryptococcus neoformans ATCC 36556 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1703582 | Permeability of the compound at pH 7.4 measured after 6 hrs by PAMPA method | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1654953 | Activation of RXRalpha in human KM12C cells assessed as reduction in c-Myc protein expression at 25 to 50 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1744529 | Inhibition of LPS + nigericin-induced IL-1beta secretion in human THP-1 cells pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID723286 | Induction of apoptosis in human HepG2 cells assessed as viable cells at 0.25 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 94.29%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID595345 | Upregulation of Rgc32 mRNA expression in rat A10 cells at 3 to 30 uM after 12 hrs by quantitative RT-PCR analysis | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID697839 | Inhibition of HFIP-induced amyloid beta (1 to 40) aggregation after 45 mins by thioflavin T fluorescence method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1654983 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as effect on PCNA protein expression at 100 mg/kg, ig dosed daily for 15 days by immunohistochemistry analysis | | | |
| AID1129728 | Reversal of high glucose-induced insulin resistance in mouse 3T3L1 cells assessed as relative sensitization rate at 0.10 umol/ml relative to rosiglitazone | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
| Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics. |
| AID378591 | Antiplasmodial activity against multi drug-resistant Plasmodium falciparum K1 in erythrocytes by [3H]hypoxanthine uptake | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID642414 | Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. |
| AID526833 | Inhibition of equine BChE after 15 mins by Ellman's method using butyrylcholine as substrate | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. |
| AID1138622 | Cmax at steady state in hypercholesterolemic patient at 15 mg/kg administered for 3 months by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID136554 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 40 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID1744533 | Inhibition of LPS + nigericin-induced IL-1beta secretion in mouse BMDM at 2.5 to 20 uM pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1744510 | Inhibition of LPS + nigericin-induced IL-1beta secretion in PMA-differentiated human THP-1 cells at 20 uM incubated for 24 hrs by ELISA | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID375855 | Binding affinity to human telomeric G-quadruplex F21T DNA assessed as change in melting temperature at 2.0 uM by FRET assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands. |
| AID593739 | Inhibition of equine serum Butyrylcholinesterase | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. |
| AID1678079 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as decrease in histological scores at 50 mg/kg administrated for 14 days by by H and E staining analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID261999 | Antibacterial activity against Escherichia coli | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5
| Synthesis and antihyperglycemic evaluation of various protoberberine derivatives. |
| AID758162 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID262001 | Binding affinity to sulfonylurea receptor in pancreatic islet beta cell membranes | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5
| Synthesis and antihyperglycemic evaluation of various protoberberine derivatives. |
| AID1138614 | Cmax in human plasma at 500 mg, po by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1654980 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as induction of beta-catenin protein degradation at 100 mg/kg, ig dosed daily for 15 days by immunohistochemistry analysis | | | |
| AID1678080 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as decrease in spleen weight at 50 mg/kg administrated for 14 days | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID642415 | Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. |
| AID723041 | Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 0.25 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 3.16%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1193496 | Thermodynamic equilibrium solubility, log S of the compound in water at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1654988 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as increase in p21 (WAF1/CIP1) mRNA expression at 100 mg/kg, ig dosed daily for 15 days by real-time PCR analysis | | | |
| AID1646867 | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID1703581 | Inhibition of HFIP-pretreated Tau (306 to 336) (unknown origin) self-aggregation at 25 uM measured at interval of 10 mins for overnight with 1 min shaking by thioflavin-T fluorescence method | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1654959 | Activation of RXRalpha in human HCT116 cells assessed as reduction in c-Myc protein expression at 30 to 60 uM incubated for 15 hrs by Western blot analysis | | | |
| AID654855 | Binding affinity to calf thymus DNA in presence of citrate-phosphate buffer at pH 7 by spectrofluorimetry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID486995 | Inhibition of equine serum BuChE by Ellman's method | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. |
| AID1681588 | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID767376 | Inhibition of amyloid beta (1-42) (unknown origin) aggregation at 20 uM after 48 hrs by thioflavin-T based fluorimetric assay relative to control | 2013 | Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
| Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. |
| AID1503097 | Inhibition of mitochondrial membranes potential in rat L6 cells assessed as mitochondrial membranes potential level at 20 uM incubated for 40 mins by JC1 dye staining based fluorescence assay (Rvb = 100 +/- 2.8%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID694190 | Increase in AMPKalpha phosphorylation in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control relative to total AMPKalpha level | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
| AID723034 | Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 1 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 2.05%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1470626 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents. |
| AID1654945 | Activation of RXRalpha (unknown origin) expressed in human KM12C cells co-expressing beta-catenin assessed as induction of RXRalpha interaction with beta-catenin at 25 to 50 uM incubated for 15 hrs by mammalian two-hybrid assay | | | |
| AID1654987 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as reduction in c-Myc mRNA expression at 100 mg/kg, ig dosed daily for 15 days by real-time PCR analysis | | | |
| AID1846552 | Antiproliferative activity against human MKN-28 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID723297 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1628115 | Antimicrobial activity against Bacillus subtilis | 2016 | Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
| Targeting the Bacterial Division Protein FtsZ. |
| AID654857 | Binding affinity to calf thymus DNA assessed as fluorescence quenching by fluorescence spectroscopy analysis | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID1647643 | Inhibition of Staphylococcus aureus sortase A | 2020 | Journal of natural products, 02-28, Volume: 83, Issue:2
| Isocadiolides A-H: Polybrominated Aromatics from a |
| AID1503100 | Inhibition of oxygen consumption rate in isolated mitochondria from rat L6 cells assessed as oxygen consumption level at 1.2 uM (Rvb = 100 +/- 1.9%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1681591 | Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1660291 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in DSS-induced inflammatory cell infiltration at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge by h | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID526832 | Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrate | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. |
| AID1101184 | Antifungal activity against Blumeria graminis f. sp. tritici on wheat plant assessed as disease control at 100 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID546784 | Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as decrease in Berberine MIC | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID723033 | Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 1 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 3.16%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID546785 | Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as decrease in Berberine MIC | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID419867 | Antibacterial activity against Escherichia coli ECM1642 after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID1744527 | Inhibition of NEK7-NLRP3 interaction (unknown origin) expressed in HEK293 cells at 10 uM incubated for 24 hrs by Co-IP assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID449706 | NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1678091 | Antifungal activity against Candida albicans 98001 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID437564 | Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. |
| AID1654943 | Activation of RXRalpha in human HCT116 cells assessed as induction of beta-catenin protein degradation at 30 to 60 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1678089 | Antibacterial activity against Pseudomonas aeruginosa 10211 incubated for 24 hrs | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID546768 | Antibacterial activity against wild-type Staphylococcus aureus 8325-4 after 18 hrs by two fold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID1678084 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as colon length at 50 mg/kg administrated for 14 days (Rvb = 8.350 +/- 1.111 cm) | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1744539 | Inhibition of Salmonella-induced NLRC4 inflammasome activation in human THP-1 cells at 10 uM pre-treatment for 2 hrs before Salmonella addition | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1326320 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID694187 | Up regulation of LDLR expression in human HepG2 cells at 10 uM after 12 hrs by RT-PCR relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
| AID1660260 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in spleen swelling at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID381931 | Cytotoxicity against Sprague-Dawley rat primary hepatocytes after 24 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID402116 | Antibacterial activity against Staphylococcus aureus after 24 hrs by serial broth dilution test | 1998 | Journal of natural products, Sep, Volume: 61, Issue:9
| Antimicrobial activity of 8-alkyl- and 8-phenyl-substituted berberines and their 12-bromo derivatives. |
| AID151349 | In vitro antimalarial activity against Plasmodium falciparum W2 | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID449703 | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID346759 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice for 30 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID136558 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 640 mg/kg; Toxic | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID595326 | Growth inhibition against rat VSMC after 72 hrs by MTT assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1654981 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as reduction in Cdc2 protein expression at 100 mg/kg, ig dosed daily for 15 days by immunohistochemistry analysis | | | |
| AID1101176 | Antifungal activity against Phytophthora infestans on rice plant at 25 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID402378 | Antimicrobial activity against Staphylococcus aureus ATCC 13709 | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID486994 | Inhibition of electric eel AChE by Ellman's assay | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. |
| AID377682 | Potentiation of drimane-type sesquiterpene-induced antifungal activity against wild type Candida albicans Al-1 assessed as fractional inhibition concentration index | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID1660329 | Effect on total S1PR1 expression in DSS-induced C57BL/6 mouse model of subchronic relapsing colitis at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by Western blot analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1654994 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring TBIL level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 0.28 +/- 0.024 umol/L) | | | |
| AID1138619 | Tmax in human assessed as jatrorrhizine at 500 mg, po by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID449704 | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1778657 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51559 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID402117 | Antibacterial activity against Bacillus subtilis after 24 hrs by serial broth dilution test | 1998 | Journal of natural products, Sep, Volume: 61, Issue:9
| Antimicrobial activity of 8-alkyl- and 8-phenyl-substituted berberines and their 12-bromo derivatives. |
| AID1678093 | Antibacterial activity against Staphylococcus aureus 261112-5 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID635418 | Antioxidant activity assessed as trolox equivalent of APPH-induced radical scavenging activity at 0.5 to 10 uM measured every 60 sec for 4 hrs by ORAC fluorescence assay relative to trolox | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. |
| AID1628394 | Cytotoxicity against human HepG2 cells assessed as cell viability at 6.25 to 100 ug/ml by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1654940 | Activation of RXRalpha in human HCT116 cells assessed as inhibition of Wnt/beta-catenin-dependent transcriptional activity at 30 to 60 uM incubated for 15 hrs by TOP/FOP luciferase assay | | | |
| AID1761720 | Down regulation of PCSK9 mRNA expression in human HepG2 cells incubated for 24 hrs by SYBR green dye-based qRT-PCR analysis | | | |
| AID1654997 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring AST level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 157.15 +/- 8.41 U/L) | | | |
| AID1654999 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring creatinine level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 27.02 +/- 1.22 umol/L) | | | |
| AID1778647 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1654926 | Inhibition of cell proliferation of human SW620 cells incubated for 15 hrs by MTT assay | | | |
| AID1744507 | Toxicity in mouse BMDM cells assessed as induction of apoptosis by measuring cleaved caspase-3 levels up to 40 uM incubated for 24 hrs by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID419862 | Antibacterial activity against wild type Staphylococcus aureus 8325-4 after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID1654952 | Activation of RXRalpha in human KM12C cells assessed as reduction in Cdc2 mRNA expression at 25 to 50 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID402118 | Antibacterial activity against Salmonella enteritidis after 24 hrs by serial broth dilution test | 1998 | Journal of natural products, Sep, Volume: 61, Issue:9
| Antimicrobial activity of 8-alkyl- and 8-phenyl-substituted berberines and their 12-bromo derivatives. |
| AID1732648 | Inhibition of amyloid beta (1 to 42 ) (unknown origin) aggregation at 10 uM after 20 hrs by thioflavin-T fluorescence method relative to control | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. |
| AID595335 | Down regulation of Prim2 mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1846549 | Antiproliferative activity against human SW620 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID379764 | Antimicrobial activity against NorA knockout Staphylococcus aureus K1758 mutant | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2
| Metabolites of the "smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. |
| AID1744531 | Inhibition of LPS + nigericin-induced NLRP3 expression in human THP-1 cells at 2.5 to 20 uM pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID378592 | Antiamnesic activity against Entamoeba histolytica NIH 200 after 72 hrs by microdilution technique | 2000 | Journal of natural products, Dec, Volume: 63, Issue:12
| In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. |
| AID1678086 | Antibacterial activity against Salmonella paratyphi B 0039 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1571756 | Stability of compound in acetonitrile/water at 1:1 ratio at pH 1.5 assessed as compound degradation after 5 hrs by HPLC analysis | 2019 | MedChemComm, Apr-01, Volume: 10, Issue:4
| Novel carbohydrate modified berberine derivatives: synthesis and |
| AID572150 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBAD plasmid after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID1654995 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring IBIL level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 0.55 +/- 0.096 umol/L) | | | |
| AID546774 | Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as accumulation of compound at 3 uM by fluorescence assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID456908 | Inhibition of electric eel AChE by enzyme kinetics assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID602118 | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | 2011 | Science (New York, N.Y.), Dec-09, Volume: 334, Issue:6061
| Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. |
| AID1484412 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA41 after 18 hrs by cation adjusted Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID1646869 | Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID449705 | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1660301 | Toxicity in DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as induction of abnormalities in liver at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge by hematoxylin and eosin staining based li | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID635419 | Inhibition of self-mediated amyloid beta (1 to 42) aggregation at 20 uM after 48 hrs by thioflavin T fluorescence assay | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. |
| AID300287 | Binding affinity to human telo21 G-quadruplex DNA at 1 uM after 5 mins | 2007 | Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
| 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. |
| AID1655007 | AUC (0 to t) in Sprague-Dawley rat at 100 mg/kg, ig measured after 0.083 to 36 hrs by LC-MS/MS analysis | | | |
| AID1678075 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in mast cells infiltration in colon tissue at 50 mg/kg administrated for 14 days by aldehyde-fuchsin orange G staining based assay | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1390872 | Activation of AMPK in Sprague-Dawley rat L6 myotube cells assessed as increase in acetyl-CoA carboxylase phosphorylation at Ser79 residues at 10 uM after 1 hr by Western blot analysis | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID402381 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID1744519 | Binding affinity to NEK7 in PMA-differentiated human THP-1 cells at 100 uM incubated for 8 hrs by streptavidin-bead enrichment and immunoblot assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID654858 | Binding affinity to calf thymus DNA in citrate-phosphate buffer at pH 7 assessed as change in viscosity by hydrodynamic method | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID456906 | Inhibition of horse serum BChE by Ellman's method | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID723296 | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1778651 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1744509 | Toxicity in mouse BMDM cells assessed as induction of apoptosis by measuring cleaved caspase-9 levels up to 40 uM incubated for 24 hrs by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1744525 | Inhibition of NEK7-NLRP3 interaction (unknown origin) expressed in HEK293 cells incubated for 24 hrs by Co-IP assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID654854 | Binding affinity to calf thymus DNA in presence of citrate-phosphate buffer at pH 7 by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID723285 | Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 0.25 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 2.05%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1484408 | Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 after 18 hrs by brain heart infusion broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID346755 | Induction of LDLR mRNA expression in human HepG2 cells after 12 hrs by RT-PCR assay relative to untreated control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1326321 | Inhibition of recombinant Escherichia coli K12 FtsZ assembly by light-scattering assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1660265 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in disease activity index at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge and measured on day 24 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID767384 | Selectivity ratio of IC50 for equine serum BChE to IC50 for electric eel AChE | 2013 | Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
| Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. |
| AID1326307 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-41 after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1654961 | Activation of RXRalpha in human HCT116 cells assessed as increase in p21 (WAF1/CIP1) protein expression at 30 to 60 uM incubated for 15 hrs by Western blot analysis | | | |
| AID419045 | Inhibition of 6-His tagged Staphylococcus aureus recombinant sortase delta N24 expressed in Escherichia coli BL21 (DE3) | 2009 | Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
| Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. |
| AID151208 | In vitro antimalarial activity against Plasmodium falciparum D6 | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID1744536 | Inhibition of LPS + nigericin-induced pro-IL-1beta expression in mouse BMDM at 2.5 to 20 uM pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1703572 | Selectivity index, ratio of IC50 for human butyrylcholinesterase in plasma using butyrylthiocholine iodide as substrate to IC50 for recombinant human acetylcholinesterase using acetylthiocholine iodide as substrate by Ellman's method | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1390865 | Activation of AMPK in Sprague-Dawley rat primary hepatocytes assessed as inhibition of gluconeogenesis by measuring glucose production at 5 uM after 6 hrs by colorimetric assay (Rvb = 100 +/- 3.5%) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID1138612 | 1-Octanol-water distribution coefficient, log D of the compound at pH 4.5 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1390873 | Inhibition of mitochondrial respiratory complex 1 in differentiated Sprague-Dawley rat L6 myotube cells assessed as mitochondrial membrane potential at 5 uM after 40 to 60 mins by JC-1 staining based fluorescence assay (Rvb = 100 +/- 1.6%) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID758167 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1138632 | Dissociation constant, basic pKa of the compound | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID590346 | Inhibition of Human immunodeficiency virus 1 NL4.3 reverse transcriptase activity at 20 ug/ml | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. |
| AID758166 | Antibacterial activity against Bacillus subtilis after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1654965 | Activation of RXRalpha in human SW620 cells assessed as reduction in c-Myc protein expression at 40 to 80 uM incubated for 15 hrs by Western blot analysis | | | |
| AID630340 | Inhibition of BChE assessed as hydrolysis of butrylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assay | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. |
| AID402382 | Antimicrobial activity against Mycobacterium smegmatis ATCC 607 | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID419869 | Antibacterial activity against Enterococcus faecalis MMH594 after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID1778656 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID419866 | Antibacterial activity against Escherichia coli K-12 after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID402120 | Antifungal activity against Candida albicans IFO 1061 after 48 hrs by serial broth dilution test | 1998 | Journal of natural products, Sep, Volume: 61, Issue:9
| Antimicrobial activity of 8-alkyl- and 8-phenyl-substituted berberines and their 12-bromo derivatives. |
| AID1724008 | Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 15 mins | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Identification of the first noncompetitive SARM1 inhibitors. |
| AID546769 | Antibacterial activity against NorA-deficient Staphylococcus aureus K1758 after 18 hrs by two fold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID697830 | Inhibition of human BChE by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID593737 | Ratio of IC50 for equine serum Butyrylcholinesterase to IC50 for electric eel Acetylcholinesterase | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. |
| AID1138628 | Effect on total triglyceride level in hypercholesterolemic patient at 15 mg/kg/day administered for 3 months measured every month during compound treatment | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID419868 | Antibacterial activity against Enterococcus faecalis OG1RF after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID657783 | Antimycobacterial activity against drug-susceptible Mycobacterium tuberculosis H37Rv measured 24 hrs post dose by microplate alamar blue assay | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Synthesis, structure-activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives. |
| AID377678 | Antifungal activity against filamentous Wangiella dermatitidis after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID456907 | Selectivity for electric eel AChE over horse serum BChE | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID1660335 | Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced TNFalpha mRNA level at 1 uM incubated for 1 hr followed by LPS challenge and measured after 4 to 6 hrs by q-PCR method | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID293735 | Selectivity index, ratio of CC50 for MRC5 cells to IC50 for HCMV | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1660338 | Inhibition of STAT3 activation in human THP1 cells assessed as reduction in LPS-induced phosphorylated STAT3 expression at 1 uM incubated for 1 hr followed by LPS challenge and measured after 4 to 6 hrs by Western blot analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID654856 | Binding affinity to calf thymus DNA in citrate-phosphate buffer at pH 7 by circular dichroism spectral analysis | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. |
| AID1484413 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID593738 | Inhibition of electric eel Acetylcholinesterase | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. |
| AID1484415 | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa ATCC BAA2108 after 18 hrs by Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID1678092 | Antibacterial activity against streptococcus hemolyticus 32210 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1660242 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as effect on body weight at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS challenge and measured after day 12 to day 18 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1138624 | Cmax at steady state in hypercholesterolemic patient assessed as demethyleneberberin at 15 mg/kg/day administered for 3 months by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1628385 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus N315 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID758163 | Antibacterial activity against Shigella dysenteriae after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1646866 | Antiproliferative activity against human DU145 cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID1628382 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1654966 | Activation of RXRalpha in human SW620 cells assessed as reduction in c-Myc mRNA expression at 40 to 80 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID546776 | Inhibition of NorA in Staphylococcus aureus K2378 overexpressing NorA assessed as accumulation of Berberine at 3 uM by fluorescence assay in presence of INF55 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID377672 | Antifungal activity against wild type Candida albicans Al-1 after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID300936 | Inhibition of SrtA | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
| Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. |
| AID501767 | Hypolipidemic activity in high fat high cholesterol diet fed Wistar rat hyperlipidemic model assessed as reduction in LDL cholesterol 100 mg/kg, po qd for 28 days | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17
| Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. |
| AID1654941 | Activation of RXRalpha in human SW620 cells assessed as inhibition of Wnt/beta-catenin-dependent transcriptional activity at 40 to 80 uM incubated for 15 hrs by TOP/FOP luciferase assay | | | |
| AID1193500 | Thermodynamic equilibrium solubility, log S of the compound | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID402119 | Antibacterial activity against Escherichia coli IFO 026 after 24 hrs by serial broth dilution test | 1998 | Journal of natural products, Sep, Volume: 61, Issue:9
| Antimicrobial activity of 8-alkyl- and 8-phenyl-substituted berberines and their 12-bromo derivatives. |
| AID1470621 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents. |
| AID526834 | Selectivity ratio of IC50 for equine BChE to IC50 for electric eel AChE | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. |
| AID1660289 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in DSS-induced multiple erosive lesions in colon at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge b | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1138621 | Plasma concentration in human assessed as berberrubine at 500 mg, po after 24 hrs by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID456905 | Inhibition of electric eel AChE by modified Ellman method | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID1193493 | Thermodynamic equilibrium solubility, log S of the compound in PBS at pH 7.4 at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID723288 | Induction of apoptosis in human HepG2 cells assessed as morphological changes at 20 uM after 24 hrs using Hoechst 33258 staining by fluorescence microscopic analysis | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1628383 | Antimicrobial activity against Escherichia coli JM109 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID379765 | Antimicrobial activity against wild-type Staphylococcus aureus 8325-4 | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2
| Metabolites of the "smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. |
| AID1654946 | Activation of RXRalpha (unknown origin) expressed in human HCT116 cells co-expressing beta-catenin assessed as induction of RXRalpha interaction with beta-catenin at 30 to 60 uM incubated for 15 hrs by mammalian two-hybrid assay | | | |
| AID723035 | Induction of apoptosis in human HepG2 cells assessed as viable cells at 1 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 94.29%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1703580 | Inhibition of HFIP-pretreated amyloid beta(1 to 42) (unknown origin) self-aggregation at 50 uM measured at interval of 10 mins for 72 hrs by thioflavin-T fluorescence method | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID590165 | Cytotoxicity against human CEM cells expressing green fluorescent protein after 48 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. |
| AID293733 | Cytotoxicity against MRC5 cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1129726 | Reversal of high glucose-induced insulin resistance in mouse 3T3L1 cells assessed as relative sensitization rate at 10 umol/ml relative to rosiglitazone | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
| Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics. |
| AID590168 | Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production at 0.29 uM measured 7 days post infection by ELISA | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. |
| AID767379 | Antioxidant activity assessed as ratio of umol of trolox equivalent to umol of compound after 10 mins by oxygen radical absorbance capacity-fluorescein assay | 2013 | Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
| Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. |
| AID1610426 | Increase in glucose consumption in human HepG2 cells assessed as glucose content in medium at 10'-6 M measured after 24 hrs by glucose oxidase method relative to control | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23
| Novel berberine-based derivatives with potent hypoglycemic activity. |
| AID658164 | Stabilization of human G-quadruplex F21T assessed as change in melting temperature at 5 uM by FRET assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. |
| AID269172 | Antifungal activity against Candida albicans ATCC 10231 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1655000 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring urea formaldehyde level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 8.21 +/- 0.26 mmol/ | | | |
| AID1660248 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in stool bleeding scores at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS challenge and measured on day 19 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1744542 | Antiinflammatory activity in NEK7 wild type C57BL/6 mouse model assessed as reduction in inflammatory infiltration in liver at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by H and E staining | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID546770 | Antibacterial activity against Staphylococcus aureus K2378 overexpressing NorA after 18 hrs by two fold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID1654957 | Activation of RXRalpha in human HCT116 cells assessed as reduction in Cdc2 protein expression at 30 to 60 uM incubated for 15 hrs by Western blot analysis | | | |
| AID402383 | Antimicrobial activity against Candida albicans ATCC 10231 | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID1660284 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in DSS-induced colon swelling at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1101183 | Antifungal activity against Phaeosphaeria nodorum on wheat plant assessed as disease control at 100 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1660302 | Toxicity in DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as induction of abnormalities in kidney at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge by hematoxylin and eosin staining based l | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1654986 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as reduction in Cdc2 mRNA expression at 100 mg/kg, ig dosed daily for 15 days by real-time PCR analysis | | | |
| AID1326322 | Inhibition of recombinant Escherichia coli K12 FtsZ GTPase activity by malachite green sodium molybdate assay | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1654982 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as reduction in c-Myc protein expression at 100 mg/kg, ig dosed daily for 15 days by immunohistochemistry analysis | | | |
| AID1138608 | 1-Octanol-water partition coefficient, log P of the compound at pH 4.5 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID723040 | Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 0.5 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 0.51%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1654958 | Activation of RXRalpha in human HCT116 cells assessed as reduction in Cdc2 mRNA expression at 30 to 60 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID1778655 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 2 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID635414 | Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. |
| AID1655008 | MRT (infinity) in Sprague-Dawley rat at 100 mg/kg, ig measured after 0.083 to 36 hrs by LC-MS/MS analysis | | | |
| AID1193498 | Thermodynamic equilibrium solubility, log S of the compound simulated gastric fluid at pH 1.2 at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1654951 | Activation of RXRalpha in human KM12C cells assessed as reduction in Cdc2 protein expression at 25 to 50 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1654949 | Activation of RXRalpha (unknown origin) expressed in human HCT116 cells co-expressing beta-catenin and c-Cbl assessed as induction of beta-caten interaction with c-Cbl at 30 to 60 uM incubated for 15 hrs by mammalian two-hybrid assay | | | |
| AID1654922 | Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay | | | |
| AID1678090 | Antibacterial activity against Streptococcus pneumoniae 32215 after 24 hrs by microdilution method | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID356228 | Antioxidant activity assessed as DPPH radical scavenging activity | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8
| Xanthones and benzophenones from the stems of Garcinia multiflora. |
| AID377194 | Antimicrobial activity against Staphylococcus aureus 4222 with norA KLE mutation at 120 to 140 ug/ml | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8
| 5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. |
| AID239781 | In vitro relative affinity for binding to d(AAGAATTCTT)2 | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
| Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities. |
| AID1193497 | Thermodynamic equilibrium solubility, log S of the compound PBS at pH 7.4 at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1703578 | Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1129727 | Reversal of high glucose-induced insulin resistance in mouse 3T3L1 cells assessed as relative sensitization rate at 1 umol/ml relative to rosiglitazone | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
| Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics. |
| AID1732650 | Ratio of compound solubility to curcumin solubility in water after 12 hrs by UV-HPLC analysis | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. |
| AID758160 | Antibacterial activity against Proteus vulgaris after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1260924 | Inhibition of Staphylococcus aureus ATCC 6538p recombinant SrtA after 1 hr by spectrometery using Dabcyl-QALPETGEE-Edans as substrate | 2015 | Journal of medicinal chemistry, Dec-10, Volume: 58, Issue:23
| Sortase A Inhibitors: Recent Advances and Future Perspectives. |
| AID1655003 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring total cholesterol level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 2.32 +/- 0.11 mmol/ | | | |
| AID419870 | Antibacterial activity against Enterococcus faecalis V583 after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID1138629 | Effect on HDL cholesterol level in hypercholesterolemic patient at 15 mg/kg/day administered for 3 months measured every month during compound treatment | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID377677 | Antifungal activity against Saccharomyces cerevisiae after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID1678069 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in TNF-alpha protein expression in colon tissue at 50 mg/kg administrated for 14 days by Western blot analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1744537 | Inhibition of LPS + nigericin-induced ASC-pyroptosome formation in human THP-1 cells at 5 to 10 uM uM pre-treatment for 4 hrs before LPS + nigericin addition by immunofluorescence analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1138604 | Solubility of the compound in sodium phosphate buffer at pH 4.5 at 25 degC after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID381932 | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID1503102 | Inhibition of oxygen consumption rate in isolated mitochondria from rat L6 cells assessed as oxygen consumption level at 5 uM (Rvb = 100 +/- 1.9%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1846551 | Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID1678085 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model of assessed as reduction in disease activity index at 50 mg/kg administrated for 14 days | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID1846548 | Antiproliferative activity against human LS174T cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID346773 | Reduction of blood cholesterol level in hyperlipidemic C57BL/6J mouse at 100 mg/kg, po daily twice for 21 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1654964 | Activation of RXRalpha in human SW620 cells assessed as reduction in Cdc2 mRNA expression at 40 to 80 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID381933 | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. |
| AID537735 | Binding affinity to Candida albicans CaMdr1p expressed in yeast AD1-8u | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID375856 | Binding affinity to human telomeric G-quadruplex F10T DNA assessed as change in melting temperature at 2.0 uM by FRET assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands. |
| AID526831 | Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrate | 2010 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
| Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. |
| AID1744545 | Antiinflammatory activity in NEK7 wild type C57BL/6 mouse model assessed as reduction in lesion in kidney in at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by H and E staining | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1744540 | Inhibition of serum IL-1beta production in NEK7 knockdown C57BL/6 mouse model at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by ELISA | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1678074 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in IL-1beta mRNA expression in colon tissue at 50 mg/kg administrated for 14 days by RT-qPCR analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID602119 | NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration | 2011 | Science (New York, N.Y.), Dec-09, Volume: 334, Issue:6061
| Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. |
| AID1654921 | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as induction of beta-catenin protein degradation at 100 mg/kg, ig dosed daily for 15 days by Western blot analysis | | | |
| AID1138610 | 1-Octanol-water distribution coefficient, log D of the compound at pH 7 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1503068 | Inhibition of glucose production in Sprague-Dawley rat primary hepatocytes grown under gluconeogenic medium assessed as glucose production level at 20 uM incubated for 6 hrs by glucose assay reagent based glucose oxidase method (Rvb = 100%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1655002 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring triglyceride level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 0.96 +/- 0.056 mmol/L) | | | |
| AID1732651 | Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. |
| AID697852 | Inhibition of electric eel AChE at 2 mg/ml by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1571755 | Cytotoxicity against human HepG2 cells after 12 hrs by CCK-8 assay | 2019 | MedChemComm, Apr-01, Volume: 10, Issue:4
| Novel carbohydrate modified berberine derivatives: synthesis and |
| AID1655006 | Cmax in Sprague-Dawley rat at 100 mg/kg, ig measured after 0.083 to 36 hrs by LC-MS/MS analysis | | | |
| AID1654944 | Activation of RXRalpha in human SW620 cells assessed as induction of beta-catenin protein degradation at 40 to 80 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1744532 | Inhibition of LPS + nigericin-induced pro-IL-beta expression in human THP-1 cells at 2.5 to 20 uM pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID367137 | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 8 uM | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
| Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists. |
| AID1138611 | 1-Octanol-water distribution coefficient, log D of the compound at pH 6 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1660263 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in stool consistency score at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge measured on day 24 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1778650 | Antibacterial activity against penicillin-susceptible Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID493707 | Cytotoxicity against human SK-MEL-2 cells by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity. |
| AID1390857 | Activation of AMPK in differentiated Sprague-Dawley rat L6 myotube cells assessed as glucose consumption at 10 uM after 12 hrs by colorimetric assay (Rvb = 100 +/- 1.8%) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID1703579 | Antioxidant activity assessed as radical scavenging activity measured after 30 mins by microplate reader based DPPH assay | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1628386 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID300937 | Antimicrobial activity against Staphylococcus aureus Newman | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
| Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. |
| AID1846550 | Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID346760 | Reduction of blood cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID419864 | Antibacterial activity against Escherichia coli BW-25116 TolC-deficient mutant after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID595334 | Downregulation of Scd2 mRNA expression in rat A10 cells at 30 uM after 24 hrs by quantitative RT-PCR analysis | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1744535 | Inhibition of LPS + nigericin-induced NLRP3 expression in mouse BMDM at 2.5 to 20 uM pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1778653 | Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID437563 | Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay | 2009 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
| Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. |
| AID1654967 | Activation of RXRalpha in human SW620 cells assessed as increase in p21 (WAF1/CIP1) protein expression at 40 to 80 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1778645 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID402385 | Antimicrobial activity against recombinant Mycobacterium bovis BCG expressing pMV361 lux after 5 days by luciferase assay | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. |
| AID1326318 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID694189 | Increase in total AMPKalpha level in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
| AID356227 | Toxicity against brine shrimp | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8
| Xanthones and benzophenones from the stems of Garcinia multiflora. |
| AID1138605 | 1-Octanol-water partition coefficient, log P of the compound at pH 8.6 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1484416 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA2470 expressing NDM-1 beta-lactamase after 18 hrs by Mueller-Hinton broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID362228 | Binding affinity to human c-myc G-quadruplex F10T DNA assessed as change melting temperature at 2.0 uM by FRET melting assay | 2008 | Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
| 9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. |
| AID1655005 | Tmax in Sprague-Dawley rat at 100 mg/kg, ig measured after 0.083 to 36 hrs by LC-MS/MS analysis | | | |
| AID1744505 | Inhibition of LPS + nigericin-induced IL-1beta secretion in mouse BMDM cells incubated with LPS followed by compound treatment for 2 hrs and stimulated with nigericin for 0.5 hrs by Immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1193494 | Thermodynamic equilibrium solubility, log S of the compound in simulated gastric fluid at pH 1.2 at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1193492 | Thermodynamic equilibrium solubility, log S of the compound in water at RT after 4 hrs by 96 well plate method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID1654955 | Activation of RXRalpha in human KM12C cells assessed as increase in p21 (WAF1/CIP1) protein expression at 25 to 50 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1724012 | Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Expi293 cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Identification of the first noncompetitive SARM1 inhibitors. |
| AID697833 | Inhibition of human AChE by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID635415 | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. |
| AID1101175 | Antifungal activity against Ustilago maydis on rice plant at 25 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1678078 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as reduction in colon damage at 50 mg/kg administrated for 14 days by H and E staining analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID362227 | Binding affinity to human c-myc G-quadruplex F10T DNA assessed as melting temperature at 2.0 uM by FRET melting assay | 2008 | Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
| 9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. |
| AID1101182 | Antifungal activity against Phytophthora infestans on potato plant assessed as disease control at 100 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1660304 | Toxicity in DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as induction of abnormalities in lung at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge by hematoxylin and eosin staining based lig | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1503101 | Inhibition of oxygen consumption rate in isolated mitochondria from rat L6 cells assessed as oxygen consumption level at 2.5 uM (Rvb = 100 +/- 1.9%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1610434 | Oral bioavailability in rat | 2019 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 29, Issue:23
| Novel berberine-based derivatives with potent hypoglycemic activity. |
| AID1660318 | Antiinflammatory activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in S1PR1 mRNA level at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by RT-qPCR analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1660257 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in colon swelling at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID697844 | Inhibition of amyloid beta (1 to 40) aggregation assessed as induction of disaggregation treated 45 mins after formation of aggregates by thioflavin T fluorescence method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1660316 | Antiinflammatory activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in TNFalpha mRNA level at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by RT-qPCR analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1660328 | Effect on total STAT3 expression in DSS-induced C57BL/6 mouse model of subchronic relapsing colitis at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by Western blot analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID723038 | Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 0.5 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 2.05%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID346756 | Induction of LDLR protein in human Bel7402 cells after 12 hrs by RT-PCR assay relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID419865 | Antibacterial activity against Escherichia coli ECM116 mar1642 overexpressing ArcAB pump after 18 hrs by twofold serial dilution method | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. |
| AID1193499 | Thermodynamic equilibrium solubility, log S of the compound simulated intestinal fluid at pH 6.8 at RT after 24 hrs by shake-flask method | 2015 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
| Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. |
| AID595325 | Antiproliferative activity against rat VSMC assessed as cell growth inhibition | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1101179 | Antifungal activity against Zymoseptoria tritici on wheat plant at 25 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1660300 | Toxicity in DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as induction of abnormalities in heart at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge by hematoxylin and eosin staining based li | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1744523 | Inhibition of purified recombinant human NEK7 incubated for 15 mins before ATP and substrate addition and further incubated for 40 mins by ADPGlo kinase assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1390862 | Cytotoxicity against Sprague-Dawley rat L6 cells assessed as cell viability at 10 uM after 12 hrs by SRB assay (Rvb = 100 +/- 1.8%) | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2',3':4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5' |
| AID1101178 | Antifungal activity against Rhizoctonia solani on rice plant at 25 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1326306 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID1628381 | Antimicrobial activity against Eberthella typhosa ATCC 14028 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID361483 | Antibacterial activity against wild type Staphylococcus aureus 8325-4 after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus. |
| AID1129730 | Increase in glucose transport in rat L6 cells assessed as sensitization rate at 1 umol/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
| Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics. |
| AID362225 | Binding affinity to human c-myc G-quadruplex Pu18 DNA assessed as melting temperature at 2.0 uM by FRET melting assay | 2008 | Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
| 9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. |
| AID261998 | Reduction of blood glucose level in alloxan induced diabetic mice at 200 mg/kg | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5
| Synthesis and antihyperglycemic evaluation of various protoberberine derivatives. |
| AID1654996 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring ALT level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 24.18 +/- 0.77 U/L) | | | |
| AID1681639 | Synergistic antiproliferative activity against human HepG2 cells assessed as combination index at 20 to 80 uM after 48 hrs in presence of 10 to 40 uM HN by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1628390 | Antimicrobial activity against Aspergillus flavus ATCC 204304 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID375857 | Selectivity for human telomeric G-quadruplex F21T DNA to ds26 duplex DNA | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands. |
| AID1646870 | Cytotoxicity against human HAF cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID1660266 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in stool consistency score at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge measured on day 43 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID595330 | Growth inhibition against human RKN cells after 48 hrs by MTT assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1654939 | Activation of RXRalpha in human KM12C cells assessed as inhibition of Wnt/beta-catenin-dependent transcriptional activity at 25 to 50 uM incubated for 15 hrs by TOP/FOP luciferase assay | | | |
| AID1138609 | 1-Octanol-water distribution coefficient, log D of the compound at pH 8.6 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1138623 | Cmax at steady state in hypercholesterolemic patient assessed as berberrubine at 15 mg/kg/day administered for 3 months by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID346775 | Induction of LDLR mRNA expression in hyperlipidemic C57BL/6J mouse liver at 100 mg/kg, po daily twice for 21 days by RT-PCR relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID269176 | Antifungal activity against Aspergillus fumigatus ATCC 16424 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1778652 | Antibacterial activity against penicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth measured by broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1732649 | Water solubility of the compound at 1 mg incubated for 12 hrs under shaking condition by UV-HPLC analysis | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. |
| AID1660303 | Toxicity in DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as induction of abnormalities in brain at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge by hematoxylin and eosin staining based li | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1138606 | 1-Octanol-water partition coefficient, log P of the compound at pH 7 after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID572151 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomegaydhE plasmid containing Escherichia coli multidrug efflux pump YdhE after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID1744526 | Inhibition of NEK7-NLRP3 interaction in human THP-1 cells incubated for 24 hrs by Co-IP assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1716607 | Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced TNF-alpha production by measuring TNF-alpha level at 1 uM preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA (Rvb = 100 +/- 0%) | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents. |
| AID1654956 | Activation of RXRalpha in human KM12C cells assessed as reduction in crease in p21 (WAF1/CIP1) mRNA expression at 25 to 50 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID269175 | Antifungal activity against Candida krusei ATCC 6258 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1101177 | Antifungal activity against Magnaporthe oryzae on rice plant at 25 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1138627 | Hypolipidemic activity in hypercholesterolemic patient assessed as reduction of LDL cholesterol level at 15 mg/kg/day administered for 3 months measured every month during compound treatment | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID594454 | Thermal stability of F10T duplex DNA assessed as stabilization temperature at 2 uM by FRET assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene. |
| AID593735 | Inhibition of amyloid-beta (1 to 42) aggregation at 20 uM after 48 hrs by fluorescence analysis using thioflavin T | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. |
| AID1660251 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in disease activity index at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS challenge and measured on day 19 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1660268 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in disease activity index at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge and measured on day 43 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID697829 | Inhibition of horse BChE by Ellman's method | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. |
| AID1654962 | Activation of RXRalpha in human HCT116 cells assessed as reduction in crease in p21 (WAF1/CIP1) mRNA expression at 30 to 60 uM incubated for 15 hrs by real-time PCR analysis | | | |
| AID1744530 | Inhibition of LPS + nigericin-induced caspase-1 activation in human THP-1 cells pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1503103 | Inhibition of oxygen consumption rate in isolated mitochondria from rat L6 cells assessed as oxygen consumption level at 10 uM (Rvb = 100 +/- 1.9%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1138631 | Dissociation constant, acidic pKa of the compound | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID546783 | Antibacterial activity against NorA-deficient Staphylococcus aureus K1758 after 18 hrs by two fold serial dilution method in presence of INF55 | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID1138603 | Solubility of the compound in sodium phosphate buffer at pH 6 at 25 degC after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1628117 | Antimicrobial activity against Escherichia coli | 2016 | Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
| Targeting the Bacterial Division Protein FtsZ. |
| AID758159 | Antifungal activity against Candida mycoderma after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1654963 | Activation of RXRalpha in human SW620 cells assessed as reduction in Cdc2 protein expression at 40 to 80 uM incubated for 15 hrs by Western blot analysis | | | |
| AID1646871 | Selectivity index, ratio of IC50 for cytotoxicity against human HAF cells assessed as cell growth inhibition by SRB assay to IC50 for antiproliferative activity against human PC3 cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID1654923 | Activation of RXRalpha LBD (unknown origin) expressed in human KM12C cells at 50 uM incubated for 15 hrs by luciferase reporter gene assay | | | |
| AID481401 | Inhibition of human recombinant POP | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9
| Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. |
| AID1678071 | Anti-inflammatory activity against DSS-induced ulcerative colitis BALB/c mouse model assessed as reduction in IL-6 protein expression in colon tissue at 50 mg/kg administrated for 14 days by Western blot analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID546777 | Inhibition of NorA in Staphylococcus aureus 8325-4 assessed as assessed as accumulation of compound at 3 uM by fluorescence assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. |
| AID658163 | Stabilization of DNA duplex hairpin structure assessed as change in melting temperature at 1 uM by FRET assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. |
| AID379767 | Antimicrobial activity against Staphylococcus aureus K2361 mutant overexpressing NorA | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2
| Metabolites of the "smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. |
| AID1101181 | Antifungal activity against Puccinia recondita on wheat plant assessed as disease control at 100 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1703574 | Inhibition of human butyrylcholinesterase in plasma using butyrylthiocholineiodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured at 2 mins interval by Ellman's method | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1654937 | Binding affinity to His-tagged RXRalpha LBD (unknown origin) expressed in Escherichia coli strain BL21 (DE3) by fluorescence quenching analysis | | | |
| AID537734 | Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1628116 | Antimicrobial activity against Staphylococcus aureus | 2016 | Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
| Targeting the Bacterial Division Protein FtsZ. |
| AID1655001 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring calcium level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 2.27 +/- 0.059 mmol/L) | | | |
| AID377680 | Antifungal activity against Alternaria alternata after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID635417 | Inhibition of equine serum BuChE using acetylcholine as substrate preincubated for 15 mins by Ellman's method | 2011 | Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. |
| AID694188 | Increase in AMPKalpha phosphorylation in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
| Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
| AID1654938 | Induction of conformational changes in His-tagged RXRalpha LBD (unknown origin) expressed in Escherichia coli strain BL21 (DE3) at 5 uM by circular dichroism spectroscopic assay | | | |
| AID1654950 | Activation of RXRalpha (unknown origin) expressed in human SW620 cells co-expressing beta-catenin and c-Cbl assessed as induction of beta-caten interaction with c-Cbl at 40 to 80 uM incubated for 15 hrs by mammalian two-hybrid assay | | | |
| AID1744534 | Inhibition of LPS + nigericin-induced caspase-1 activation in mouse BMDM at 2.5 to 20 uM pre-treatment for 4 hrs before LPS + nigericin by immunoblot analysis | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1654924 | Activation of RXRalpha R371S mutant LBD (unknown origin) expressed in human KM12C cells at 50 uM incubated for 15 hrs by luciferase reporter gene assay | | | |
| AID1846553 | Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID1744544 | Antiinflammatory activity in NEK7 wild type C57BL/6 mouse model assessed as reduction in lesion in lung in at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by H and E staining | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID1654998 | Toxicity in BALB/c mouse xenografted with human KM12C cells assessed as effect on biochemical parameter by measuring ALP level at 100 mg/kg, ig dosed daily for 15 days by automatic chemistry analyzer based analysis (Rvb = 76.53 +/- 4.31 U/L) | | | |
| AID269177 | Antifungal activity against Aspergillus terreus ATCC 46941 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 16, Issue:15
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. |
| AID1660267 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reduction in stool bleeding at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge measured on day 43 | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1660327 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in phosphorylated STAT3 level at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by Western blot an | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1101174 | Herbicidal activity against Agrostis stolonifera var. palustris at 1 ppm after 9 days relative to control | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID456909 | Inhibition of horse serum BChE by enzyme kinetics assay | 2010 | Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. |
| AID346757 | Induction of LDLR protein expression in human HepG2 cells at 10 ug/mL after 12 hrs by flow cytometry | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
| AID1326319 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1144 after 18 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. |
| AID723039 | Induction of apoptosis in human HepG2 cells assessed as viable cells at 0.5 uM after 24 hrs using annexin-V/FITC/propidium iodide staining by flow cytometry analysis (Rvb = 94.29%) | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1503098 | Inhibition of oxygen consumption rate in rat L6 cells assessed as oxygen consumption level at 10 uM (Rvb = 100 +/- 1.6%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1628387 | Antimicrobial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1129729 | Increase in glucose transport in rat L6 cells assessed as sensitization rate at 10 umol/ml | 2014 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 24, Issue:7
| Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics. |
| AID362226 | Binding affinity to human c-myc G-quadruplex Pu18 DNA assessed as change melting temperature at 2.0 uM by FRET melting assay | 2008 | Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
| 9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. |
| AID377679 | Antifungal activity against Pseudallescheria boydii after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID361484 | Antibacterial activity against Staphylococcus aureus K2378 overexpressing NorA after 18 to 20 hrs by serial dilution method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus. |
| AID723295 | Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID1646865 | Antiproliferative activity against human PC3 cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID1484407 | Antibacterial activity against antibiotic-susceptile Enterococcus faecium ATCC 49624 after 18 hrs by brain heart infusion broth microdilution method | 2017 | European journal of medicinal chemistry, Jul-28, Volume: 135 | Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. |
| AID243248 | Ratio of maximum concentration bound and specificity sum for triplex nucleic acids | 2004 | Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
| Structural selectivity of aromatic diamidines. |
| AID1654947 | Activation of RXRalpha (unknown origin) expressed in human SW620 cells co-expressing beta-catenin assessed as induction of RXRalpha interaction with beta-catenin at 40 to 80 uM incubated for 15 hrs by mammalian two-hybrid assay | | | |
| AID1411730 | Inhibition of recombinant human CYP1A1 expressed in baker's yeast-derived microsomes (Sacchrosomes) at 10 uM using 7-ethoxyresorufin substrate by EROD assay relative to control | 2018 | MedChemComm, Feb-01, Volume: 9, Issue:2
| Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy |
| AID1138602 | Solubility of the compound in sodium phosphate buffer at pH 7 at 25 degC after 1 week by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1628388 | Antimicrobial activity against Micrococcus luteus ATCC 4698 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID590166 | Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. |
| AID1614998 | Inhibition of Staphylococcus aureus SrtA using dabcyl-QALPETGEE-edans as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for 1 hr by fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
| Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action. |
| AID377673 | Antifungal activity against azole-resistant Candida albicans D10 after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID293734 | Antiviral activity against HCMV in MRC5 cells by plaque reduction assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1703571 | Inhibition of recombinant human Prolyl oligopeptidase expressed in Escherichia coli expression system using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured for 30 mins by spectrophoto | 2020 | European journal of medicinal chemistry, Oct-01, Volume: 203 | Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. |
| AID1744541 | Inhibition of serum IL-1beta production in NEK7 wild type C57BL/6 mouse model at 5 mg/kg, ip dosed three times every 12 hrs followed by LPS challenge by ELISA | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID767385 | Inhibition of equine serum BChE using butylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's method | 2013 | Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
| Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. |
| AID1681590 | Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine. |
| AID1678066 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as inhibited inflammation in colon at 50 mg/kg administrated for 14 days by H and E staining analysis | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID758168 | Antibacterial activity against methicillin-resistant Staphylococcus aureus N315 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID397122 | Inhibition of HIV1 RT | | | |
| AID1744528 | Inhibition of NEK7 R121A mutant-NLRP3 interaction (unknown origin) expressed in HEK293 cells at 10 uM incubated for 24 hrs by Co-IP assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID493708 | Cytotoxicity against human HCT15 cells by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity. |
| AID1660281 | Anti-colitis activity against DSS-induced C57BL/6 mouse model of chronic relapsing colitis assessed as reversal of DSS-induced colon shortening at 40 mg/kg, po administered once daily for 30 days starting from day 13 post DSS-challenge | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID333503 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus 1126 after 24 hrs | 2004 | Journal of natural products, Nov, Volume: 67, Issue:11
| A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis. |
| AID595331 | Growth inhibition against human G402 cells after 48 hrs by MTT assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. |
| AID1660339 | Inhibition of STAT3 activation in human THP1 cells assessed as reduction in LPS-induced phosphorylated STAT3 expression at 0.5 uM cotreated with 0.5 uM berberine incubated for 1 hr followed by LPS challenge and measured after 4 to 6 hrs by Western blot an | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID767386 | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's method | 2013 | Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
| Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity. |
| AID1628389 | Antimicrobial activity against Candida utilis ATCC 9950 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1724013 | Inhibition of purified human SARM1 TIR domain (561 to 724 residues) using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Identification of the first noncompetitive SARM1 inhibitors. |
| AID293737 | Inhibition of HCMV proliferation in MRC5 cells after 24 hrs post-infection at 10 uM by plaque assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Antiviral activity of berberine and related compounds against human cytomegalovirus. |
| AID1138625 | Cmax at steady state in hypercholesterolemic patient assessed as jatrorrhizine at 15 mg/kg/day administered for 3 months by HPLC-ESIMS/MS analysis | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. |
| AID1470628 | Cytotoxicity against human LO2 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents. |
| AID1628393 | Antimicrobial activity against Candida mycoderma ATCC 9888 incubated for 24 hrs by NCCLS protocol based method | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. |
| AID1778649 | Antibacterial activity against penicillin-susceptible Pseudomonas aeruginosa ATCC27853 assessed as bacterial growth inhibition incubated for 24 hrs by CLSI protocol based broth microdilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID723293 | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. |
| AID537733 | Binding affinity to Candida albicans CaCdr1p expressed in yeast AD1-8u | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. |
| AID1846547 | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | An insight into the medicinal attributes of berberine derivatives: A review. |
| AID1101180 | Antifungal activity against Phaeosphaeria nodorum on wheat plant at 25 ppm after 24 hr | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID1503099 | Inhibition of oxygen consumption rate in rat L6 cells assessed as oxygen consumption level at 20 uM (Rvb = 100 +/- 1.6%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes. |
| AID1744506 | Toxicity in mouse BMDM cells assessed as induction of cell death up to 40 uM incubated for 24 hrs by MTS assay | 2021 | Journal of medicinal chemistry, 01-14, Volume: 64, Issue:1
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. |
| AID239782 | In vitro relative affinity for binding to d(TA AGAATTCTTA)2 | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
| Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities. |
| AID377681 | Antifungal activity against wild type Candida albicans Al-1 in presence of dillapiol | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID1646868 | Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition by SRB assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. |
| AID1654976 | Antitumor activity against human KM12C cells xenografted in BALB/c mouse assessed as inhibition of tumor growth at 100 mg/kg, ig dosed daily for 15 days relative to control | | | |
| AID758165 | Antibacterial activity against Micrococcus luteus ATCC 4698 after 24 hrs by twofold broth dilution method | 2013 | Bioorganic & medicinal chemistry, Jul-15, Volume: 21, Issue:14
| Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin. |
| AID1678082 | Anti-ulcerative colitis activity in DSS-induced BALB/c mouse ulcerative colitis model assessed as colon length/colon weight ratio at 50 mg/kg administrated for 14 days (Rvb = 22.608 +/- 2.655 cm/g) | 2020 | Bioorganic & medicinal chemistry, 10-15, Volume: 28, Issue:20
| Design, synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis. |
| AID377675 | Antifungal activity against Cryptococcus neoformans after 48 hrs by NCCLS M27A method | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. |
| AID1470627 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, May-26, Volume: 132 | Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents. |
| AID493705 | Cytotoxicity against human A549 cells by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity. |
| AID1660317 | Antiinflammatory activity against DSS-induced C57BL/6 mouse model of subchronic relapsing colitis assessed as reduction in IL6 mRNA level at 40 mg/kg, po administered once daily for 14 days starting from day 5 post DSS-challenge by RT-qPCR analysis | 2020 | Journal of natural products, 06-26, Volume: 83, Issue:6
| Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models. |
| AID1778644 | Antibacterial activity against penicillin-susceptible Bacillus pumilus CMCC 63202 assessed as bacterial growth inhibition by broth dilution method | 2021 | European journal of medicinal chemistry, Oct-05, Volume: 221 | Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents. |
| AID1101173 | Herbicidal activity against Lemna minor (common duckweed) at 1 ppm after 9 days relative to control | 2000 | Bioscience, biotechnology, and biochemistry, Sep, Volume: 64, Issue:9
| Fungicidal and herbicidal activities of berberine related alkaloids. |
| AID630339 | Inhibition of AChE assessed as hydrolysis of acetylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assay | 2011 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
| Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. |
| AID493706 | Cytotoxicity against human SKOV3 cells by SRB assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
| Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |