Page last updated: 2024-08-05 12:21:40
fenfluramine
A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
ChEBI ID: 5000
Members (1)
| Member | Definition | Role |
|---|
| dexfenfluramine | The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects. | (S)-fenfluramine |
Research
Studies (211)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|
| pre-1990 | 4 (1.90) | 18.7374 |
| 1990's | 56 (26.54) | 18.2507 |
| 2000's | 123 (58.29) | 29.6817 |
| 2010's | 25 (11.85) | 24.3611 |
| 2020's | 3 (1.42) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|
| Trials | 17 (7.52%) | 5.53% |
| Reviews | 32 (14.16%) | 6.00% |
| Case Studies | 15 (6.64%) | 4.05% |
| Observational | 1 (0.44%) | 0.25% |
| Other | 161 (71.24%) | 84.16% |