Roles > antihypotensive agent
Page last updated: 2024-08-05 15:28:11
antihypotensive agent
A cardiovascular drug that tends to raise reduced blood pressure.
ChEBI ID: 137431
Members (2)
| Member | Definition | Class |
|---|
| amezinium | A pyridazinium ion that is pyridazin-1-ium which is substituted by a phenyl, amino and methoxy groups at positions 1, 4 and 6, respectively. | amezinium |
| methoxamine | An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine . | methoxamine |
Research
Studies (2,078)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 1,268 (61.02) | 18.7374 |
| 1990's | 526 (25.31) | 18.2507 |
| 2000's | 190 (9.14) | 29.6817 |
| 2010's | 79 (3.80) | 24.3611 |
| 2020's | 15 (0.72) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 68 (3.09%) | 5.53% |
| Reviews | 56 (2.54%) | 6.00% |
| Case Studies | 29 (1.32%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,048 (93.05%) | 84.16% |
Protein Targets (11)
Potency Measurements
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
Other Measurements