A cardiovascular drug that tends to raise reduced blood pressure.
ChEBI ID: 137431
| Member | Definition | Class |
|---|---|---|
| amezinium | A pyridazinium ion that is pyridazin-1-ium which is substituted by a phenyl, amino and methoxy groups at positions 1, 4 and 6, respectively. | amezinium |
| methoxamine | An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine . | methoxamine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,268 (61.02) | 18.7374 |
| 1990's | 526 (25.31) | 18.2507 |
| 2000's | 190 (9.14) | 29.6817 |
| 2010's | 79 (3.80) | 24.3611 |
| 2020's | 15 (0.72) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 68 (3.09%) | 5.53% |
| Reviews | 56 (2.54%) | 6.00% |
| Case Studies | 29 (1.32%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,048 (93.05%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| arylsulfatase A | Homo sapiens (human) | Potency | 0.2685 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.7569 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 8.1995 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 14.6892 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 11.2202 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 4.5724 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kb | 0.0110 | 1 | 2 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kb | 0.0110 | 1 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kb | 0.0110 | 1 | 2 |