Any antifungal agent used to prevent or treat fungal infections in humans or animals.
| Member | Definition | Class |
|---|
| butenafine | Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections. | butenafine |
| candicidin | A 38-membered ring lactone containing seven (E)-double bonds between positions 22 and 35 and substituted by hydroxy groups at positions 9, 11, 13, 17 and 19, oxo groups at positions 3, 7 and 15, a carboxy group at position 18, a 3-amino-3,6-dideoxymannopyranosyloxy group at position 21, a methyl group at position 36 and a 7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl group at position 37. It is the major component of candicidin, a mixture of antifungal heptaene macrolides obtained from a strain of Streptomyces griseus. | candicidin D |
| chloroxine | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp. | chloroxine |
| chlorphenesin | Glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm. | chlorphenesin |
| malachite green | An organic chloride salt that is the monochloride salt of malachite green cation. Used as a green-coloured dye, as a counter-stain in histology, and for its anti-fungal properties in aquaculture. | malachite green |
| neticonazole | An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections. | neticonazole |
| propionic acid | A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group. | propionic acid |
| pyrrolnitrin | A member of the class of pyrroles carrying chloro and 3-chloro-2-nitrophenyl substituents at positions 3 and 4 respectively. | pyrrolnitrin |
| ravuconazole | A member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4) | ravuconazole |
| siccanin | | Siccanin |
| sodium propionate | An organic sodium salt comprising equal numbers of sodium and propionate ions. | sodium propionate |
| sodium thiosulfate | An inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. | sodium thiosulfate |
| thimerosal | An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent. | thimerosal |
| thiophanate | A member of the class of thioureas that is the diethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould. | thiophanate |
| tolciclate | | Tolciclate |
| tolnaftate | A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm. | tolnaftate |
| triacetin | A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections. | triacetin |
| undecylenic acid | An undecenoic acid having its double bond in the 10-position. It is derived from castor oil and is used for the treatment of skin problems. | 10-undecenoic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 0.2818 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 13.2380 | 2 | 6 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.5258 | 3 | 6 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 25.1656 | 2 | 9 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 3.6287 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 2.5873 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 26.9680 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 19.1109 | 10 | 49 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.8206 | 2 | 13 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 13.5303 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 6.8819 | 1 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 14.1254 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 7.7775 | 2 | 6 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 5.3080 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 3.3491 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 5.3080 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 3.3491 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 27.4325 | 3 | 14 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 2.6809 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 24.8033 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 22.3872 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 30.2117 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0112 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 11.8732 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 9.1596 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 41.4904 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.1257 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 11.0319 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.7172 | 2 | 9 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 7.6032 | 2 | 11 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.1013 | 1 | 6 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 52.4870 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 24.9054 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.7264 | 12 | 55 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 11.3789 | 2 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 15.0520 | 6 | 38 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 16.2807 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 9.8641 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 13.9557 | 5 | 12 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 30.3473 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 10.1257 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.7304 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 8.6882 | 2 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 10.0621 | 2 | 14 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 13.1117 | 1 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 21.4123 | 5 | 18 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 9.4212 | 1 | 5 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 23.3507 | 2 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 12.0774 | 2 | 10 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.8966 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 22.5913 | 2 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 15.5133 | 2 | 7 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.1257 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 4.7476 | 1 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 8.4218 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 15.3412 | 2 | 11 |
| IDH1 | Homo sapiens (human) | Potency | 11.4536 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.1257 | 1 | 10 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 2.9944 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 2.9944 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 15.0892 | 2 | 8 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 14.4290 | 1 | 8 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 5.0119 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.6823 | 3 | 7 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 21.3411 | 2 | 6 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.0707 | 2 | 3 |
| Nrf2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 18.7044 | 4 | 16 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 14.9704 | 2 | 9 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 1.0591 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 326.4352 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.6879 | 3 | 26 |
| P53 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.1995 | 2 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.7564 | 5 | 12 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 17.6210 | 5 | 15 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 15.8489 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.1912 | 1 | 2 |
| polyprotein | Zika virus | Potency | 30.3473 | 1 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 4.9562 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.8750 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 19.3649 | 1 | 5 |
| PPM1D protein | Homo sapiens (human) | Potency | 23.3617 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 11.9736 | 2 | 15 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 11.3886 | 2 | 10 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.4952 | 2 | 18 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.4394 | 3 | 29 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 8.1050 | 4 | 21 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 2.6679 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 13.7009 | 2 | 8 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 13.7009 | 2 | 8 |
| Smad3 | Homo sapiens (human) | Potency | 4.0075 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 28.7968 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 27.8506 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 11.6046 | 2 | 14 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 15.8489 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 28.3982 | 1 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.4334 | 2 | 16 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 51.2087 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.0063 | 5 | 12 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 31.0998 | 2 | 3 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.1912 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.1912 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 51.0570 | 1 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 17.7828 | 2 | 15 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 10.5310 | 4 | 10 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 45.1071 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 9.4212 | 1 | 5 |
| Vpr | Human immunodeficiency virus 1 | Potency | 3.8146 | 1 | 2 |