An acaricide that kills mites of the genus Sarcoptes.
ChEBI ID: 73333
| Member | Definition | Class |
|---|---|---|
| benzyl benzoate | A benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. | benzyl benzoate |
| crotamiton | An enamide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporates from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred. | crotamiton |
| permethrin | A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups. | permethrin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 262 (9.93) | 18.7374 |
| 1990's | 432 (16.38) | 18.2507 |
| 2000's | 719 (27.26) | 29.6817 |
| 2010's | 887 (33.62) | 24.3611 |
| 2020's | 338 (12.81) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 256 (9.02%) | 5.53% |
| Reviews | 166 (5.85%) | 6.00% |
| Case Studies | 175 (6.17%) | 4.05% |
| Observational | 9 (0.32%) | 0.25% |
| Other | 2,232 (78.65%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 28.1838 | 1 | 1 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 30.9100 | 3 | 3 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 49.0259 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 22.3872 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 53.1764 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 11.7031 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.6253 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 30.1144 | 5 | 12 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 29.6831 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 10.7688 | 2 | 2 |
| geminin | Homo sapiens (human) | Potency | 23.0572 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 25.2430 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 26.7195 | 2 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 12.9144 | 2 | 6 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 12.8416 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 38.4518 | 1 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 6.1118 | 3 | 5 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 12.7748 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 32.3351 | 2 | 6 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 37.2750 | 1 | 4 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 27.2923 | 2 | 8 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 15.9969 | 3 | 10 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 26.2728 | 3 | 4 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.6310 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0052 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.1156 | 2 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 30.1347 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 10.9369 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Beta-lactamase | Escherichia coli K-12 | IC50 | 90.0000 | 1 | 1 |
| Chain A, ODORANT-BINDING PROTEIN | Sus scrofa (pig) | IC50 | 3.9000 | 1 | 5 |
| Chain B, Odorant-binding Protein | Sus scrofa (pig) | IC50 | 3.9000 | 1 | 1 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 | 250.0000 | 1 | 1 |
| Hormone-sensitive lipase | Rattus norvegicus (Norway rat) | IC50 | 1.1000 | 1 | 1 |
| Malate dehydrogenase, cytoplasmic | Homo sapiens (human) | IC50 | 125.0000 | 1 | 1 |