Spherocytosis, Hereditary

A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.

Synonym
Spherocytosis, Hereditary

Excerpt	Reference
"Hereditary spherocytosis is a rather uncommon disease in Malaysia as only 16 patients were seen in our hospital over a 13 year period."	( Koh, MT; Ng, SC, 1991)
"Hereditary spherocytosis is the most frequently occurring haemolytic anaemia."	( Balcerska, A; Irga, N; Neuman-Łaniec, M; Wasilewska, E; Wierzba, J, 2002)
"Hereditary spherocytosis is a group of heterogenous disorders characterized by variability in its clinical manifestations, membrane protein defects and inheritance."	( Bonduel, M; Díaz, L; Eberle, SE; Sciuccati, G; Staciuk, R; Torres, AF, 2007)
"Hereditary spherocytosis is a common hemolytic anemia with an estimated incidence of 1 / 2500 births."	( Canbay, A; Dechêne, A; Dührsen, U; Gerken, G; Lammert, F; Müller-Beissenhirtz, H; Nückel, H; Wree, A, 2011)
"Hereditary spherocytosis is autosomal dominant inherited extravascular hemolytic disorder and is the commonest cause of inherited hemolysis in northern Europe and the United States."	( Kitamura, Y; Suzuki, R; Tateno, Y, 2016)

Excerpt	Reference
"Splenectomy is the recommended treatment for hereditary spherocytosis to avoid the complications of aplastic or hemolytic crisis."	( Friedman, EW; Van Hook, L; Williams, JC, 1988)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	392 (65.01)	23.3326
1990's	58 (9.62)	12.5806
2000's	58 (9.62)	18.1394
2010's	76 (12.60)	28.8240
2020's	19 (3.15)	9.53

Drug	Relationship Strength	Studies	Trials
2,3-diphosphoglycerate	low	2	0
acetone	low	1	0
1-butanol	low	1	0
carbon monoxide	low	5	0
choline	low	2	0
chlorine	low	4	0
hydrochloric acid	low	1	0
glycine	low	1	0
glycerol	low	24	0
hydrogen carbonate	low	5	0
orotic acid	low	1	0
phenylacetic acid	low	1	0
phosphoenolpyruvate	low	4	0
sulfites	low	1	0
urea	low	3	0
1-anilino-8-naphthalenesulfonate	low	2	0
2,4-dinitrophenol	low	2	0
mercaptoethanol	low	2	0
phenytoin	low	1	0
acetazolamide	low	1	0
theophylline	low	1	0
aspirin	low	4	0
azathioprine	low	1	0
busulfan	low	1	0
verapamil	low	1	0
chlorothiazide	low	1	0
chlorpromazine	low	2	0
deferoxamine	low	2	0
dipyridamole	low	2	0
erythrosine	low	1	0
flumazenil	low	1	0
furosemide	low	2	0
hydralazine	low	1	0
hydroxyurea	low	2	0
iodoacetamide	low	1	0
iohexol	low	1	0
ethylmaleimide	low	3	0
pentoxifylline	low	2	0
phenobarbital	low	5	0
potassium chloride	low	1	0
primaquine	low	3	0
sodium fluoride	low	3	0
stearic acid	low	1	0
theobromine	low	1	0
prednisolone	low	4	0
reserpine	low	1	0
sorbitol	low	1	0
thymidine	low	2	0
prednisone	low	7	0
isoflurophate	low	4	0
alanine	low	2	0
chloramphenicol	low	1	0
aspartic acid	low	1	0
glutamine	low	1	0
lysine	low	1	0
sucrose	low	3	0
adenosine diphosphate	low	4	0
galactose	low	1	0
edetic acid	low	3	0
adenosine monophosphate	low	2	0
leucine	low	2	0
methionine	low	1	0
desoxycorticosterone	low	1	0
colchicine	low	1	0
egtazic acid	low	1	0
trifluridine	low	1	0
threonine	low	1	0
arginine	medium	4	1
tert-butylhydroperoxide	low	1	0
tromethamine	low	1	0
methylmethacrylate	low	1	0
phenylhydrazine	low	2	0
acridines	low	1	0
betamethasone	low	1	0
nandrolone	low	1	0
dextropropoxyphene	low	1	0
glycocholic acid	low	1	0
copper gluconate	low	1	0
maleimide	low	1	0
malondialdehyde	low	1	0
trinitrobenzenesulfonic acid	low	1	0
eosine yellowish-(ys)	medium	41	2
hematoporphyrin	low	1	0
4-chloromercuribenzenesulfonate	low	2	0
ethylnitrosourea	low	2	0
d-alpha tocopherol	low	2	0
fluorescein-5-isothiocyanate	low	1	0
dithiothreitol	low	1	0
carbonates	low	1	0
acetylthiocholine	low	1	0
mercury	low	1	0
molybdenum	low	1	0
technetium	low	4	0
chromium	low	1	0
magnesium sulfate	low	1	0
acetylglucosamine	low	1	0
trolamine salicylate	low	3	0
ammonium chloride	low	1	0
tetrathionic acid	low	1	0
urobilinogen	low	4	0
cephalexin	low	1	0
fluorides	low	1	0
phenyl acetate	low	1	0
pyrene	low	1	0
transferrin	low	10	0
ticarcillin	low	1	0
ribavirin	low	1	0
methyldopa	low	1	0
adenosine	low	4	0
vanadates	low	1	0
edda	low	1	0
glucose, (beta-d)-isomer	low	1	0
triazoles	low	1	0
fibrinogen	low	4	0
n,n'-diallyltartardiamide	low	1	0
cobalt	low	1	0
fructose 2,6-diphosphate	low	1	0
dihydro-dids	low	1	0
beta-lactams	low	1	0
proline	low	2	0
deferasirox	low	1	0
cortisone	low	1	0
s-adenosylhomocysteine	low	1	0
glycogen	low	1	0
formiminoglutamic acid	low	1	0
inositol 1,4,5-trisphosphate	low	1	0
ouabain	low	17	0
tosylphenylalanyl chloromethyl ketone	low	1	0
strychnine	low	1	0
meropenem	low	1	0
oleic acid	low	1	0
isomethyleugenol	low	2	0
urocanic acid	low	1	0
4-maleimido-2,2,6,6-tetramethylpiperidinooxyl	low	1	0
nadp	low	3	0
valinomycin	low	1	0
lithium	low	2	0
sodium dodecyl sulfate	low	3	0
zinc protoporphyrin ix	low	1	0
alpha-chymotrypsin	low	1	0
bilirubin	low	61	0
4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid	low	2	0
phenylephrine hydrochloride	low	1	0
lysophosphatidylcholines	low	8	0
lead	low	1	0
diamide	low	1	0
rubidium	low	1	0
sulfur	low	1	0
cysteine	low	1	0
phosphorus	low	2	0
urobilin	low	1	0
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid	low	4	0
oxalates	low	2	0
brl 28500	low	1	0
beta-escin	low	2	0
ns 1652	low	1	0
losartan potassium	low	18	0
calcimycin	low	2	0
acid phosphatase	low	2	0
nad	low	2	0
ristocetin	low	1	0
cellulose	low	1	0
phosphatidylcholines	low	8	0
sodium salicylate	low	1	0
sodium nitrite	low	1	0
merocyanine dye	low	1	0
piperacillin, tazobactam drug combination	low	1	0
phosphatidylinositol 4-phosphate	low	1	0
s-adenosylmethionine	low	1	0
intrinsic factor	low	1	0
glycolipids	low	4	0
natriuretic peptide, brain	low	1	0
heme	low	11	0
ascorbic acid	low	1	0
warfarin	low	2	0
agar	low	1	0
caseins	low	1	0
epoetin alfa	low	1	0
vitamin b 12	low	6	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	1	0
exudates	low	2	0
cyclic gmp	low	2	0
guanosine triphosphate	low	1	0
hypoxanthine	low	1	0
folic acid	low	18	0
allopurinol	low	1	0
guanylyl imidodiphosphate	low	1	0
phosphorus radioisotopes	low	6	0
pyrimidinones	low	1	0
filipin	low	1	0

Protein Targets (1,374)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	34	0	0	34
USP1 protein, partial	19	0	0	19
TDP1 protein	35	0	0	35
vitamin D3 receptor isoform VDRA	16	0	0	16
importin subunit beta-1 isoform 1	8	0	0	8
flap endonuclease 1	14	0	0	14
serine/threonine-protein kinase PLK1	6	0	0	6
snurportin-1	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	14	0	0	14
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	37	0	0	37
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	3	2	5
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	2	1	3
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	1	1	2
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	22	0	0	22
aldehyde dehydrogenase 1 family, member A1	37	0	0	37
glucocorticoid receptor [Homo sapiens]	40	0	0	40
farnesoid X nuclear receptor	19	0	0	19
estrogen nuclear receptor alpha	56	0	0	56
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Cellular tumor antigen p53	30	0	0	30
Glutamate receptor 2	19	0	0	19
Choline O-acetyltransferase	0	1	0	3
acetylcholinesterase	12	0	0	12
pregnane X receptor	7	0	0	7
RAR-related orphan receptor gamma	35	0	0	35
GLI family zinc finger 3	37	0	0	37
AR protein	45	0	0	45
thyroid stimulating hormone receptor	23	0	0	23
estrogen receptor 2 (ER beta)	19	0	0	19
nuclear receptor subfamily 1, group I, member 3	26	0	0	26
retinoic acid nuclear receptor alpha variant 1	43	0	0	43
retinoid X nuclear receptor alpha	27	0	0	27
estrogen-related nuclear receptor alpha	49	0	0	49
67.9K protein	10	0	0	10
peroxisome proliferator-activated receptor delta	23	0	0	23
peroxisome proliferator activated receptor gamma	25	0	0	25
vitamin D (1,25- dihydroxyvitamin D3) receptor	28	0	0	28
aryl hydrocarbon receptor	14	0	0	14
cellular tumor antigen p53 isoform a	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	13	0	0	13
thyroid hormone receptor beta isoform a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	16	0	0	17
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
thyroid hormone receptor beta isoform 2	31	0	0	31
histone deacetylase 9 isoform 3	3	0	0	3
mitogen-activated protein kinase 1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	41	0	0	41
nuclear receptor ROR-gamma isoform 1	11	0	0	11
survival motor neuron protein isoform d	18	0	0	18
histone acetyltransferase KAT2A isoform 1	13	0	0	13
Integrin beta-3	5	1	0	6
Integrin alpha-IIb	5	1	0	6
Nuclear receptor ROR-gamma	11	0	0	11
TAR DNA-binding protein 43	9	0	0	9
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	14	0	0	14
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	21	0	0	21
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	11	0	0	11
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	3	0	3
GALC protein	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	2	0	2
arylsulfatase A	20	0	0	20
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	39	0	0	39
Bloom syndrome protein isoform 1	22	0	0	22
peripheral myelin protein 22	15	0	0	15
muscleblind-like protein 1 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	15	4	0	19
ATP-binding cassette sub-family C member 3	0	27	0	27
Multidrug resistance-associated protein 4	0	28	0	30
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	5
Carbonic anhydrase 12	0	3	1	7
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	37	0	38
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	13	1	22
Carbonic anhydrase 2	0	15	2	25
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	4	1	5
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	7	0	8
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	4	1	5
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	9	0	9
5-hydroxytryptamine receptor 2A	0	4	0	4
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	15	4	0	19
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	15	4	0	19
Gamma-aminobutyric acid receptor subunit gamma-2	15	4	0	19
Gamma-aminobutyric acid receptor subunit alpha-5	15	4	0	19
Gamma-aminobutyric acid receptor subunit alpha-3	15	4	0	19
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	11	1	14
Carbonic anhydrase 6	0	4	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	15	4	0	19
Gamma-aminobutyric acid receptor subunit alpha-2	15	4	0	19
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	1	8
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	15	4	0	19
Gamma-aminobutyric acid receptor subunit gamma-3	15	4	0	19
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	15	4	0	19
Adenosine receptor A2a	0	5	1	8
5-hydroxytryptamine receptor 2B	0	4	0	4
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	7	1	11
Carbonic anhydrase	0	8	0	8
Kappa-type opioid receptor	0	2	0	3
Carbonic anhydrase 7	0	4	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	4	1	0	5
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	15	5	0	20
Gamma-aminobutyric acid receptor subunit beta-3	15	4	0	19
Gamma-aminobutyric acid receptor subunit beta-2	15	4	0	19
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	5	1	6
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	7	2	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	15	4	0	19
Canalicular multispecific organic anion transporter 1	0	26	0	26
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 15	0	5	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	6
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	15	4	0	19
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 14	0	3	1	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	8
lamin isoform A-delta10	33	0	0	33
Putative glycosyltransferase WbgO	0	0	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
regulator of G-protein signaling 4	19	0	0	19
cytochrome P450 2C19 precursor	9	0	0	9
Chain A, Ferritin light chain	8	0	0	8
Microtubule-associated protein tau	16	0	0	16
Smad3	10	0	0	10
alpha-galactosidase	6	0	0	6
DNA topoisomerase 2-alpha	0	0	0	1
Acetylcholinesterase	0	5	1	7
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	2	2
IDH1	19	0	0	19
Histone H2A.x	17	0	0	17
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	3	3
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	10	0	0	10
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	4	2	7
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	3
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	4	5	11
Adenosine receptor A2b	0	2	1	5
Adenosine receptor A2b	0	3	1	5
Adenylate kinase 2, mitochondrial	0	2	0	3
Adenosine receptor A1	0	5	4	12
Adenylate kinase isoenzyme 1	0	2	0	3
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	2	1	3
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	3	1	4
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	2
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	2	3	5
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	4	1	5
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	8	0	0	8
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
P2Y purinoceptor 11	0	0	2	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	2	0	2
Alcohol dehydrogenase S chain	0	2	0	2
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	4
Fructose-1,6-bisphosphatase 1	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	2	1	3
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	16	0	0	16
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	1	7
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
interleukin 8	10	0	0	10
progesterone receptor	21	0	0	21
transcriptional regulator ERG isoform 3	5	0	0	5
ras-related protein Rab-9A	7	0	0	7
Polyphenol oxidase 2	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	15	0	0	15
NFKB1 protein, partial	7	0	0	7
GLS protein	16	0	0	16
chromobox protein homolog 1	28	0	0	28
muscarinic acetylcholine receptor M1	18	0	0	18
lethal factor (plasmid)	19	0	0	19
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Spike glycoprotein	14	1	2	17
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	1	5
Glutamate receptor ionotropic, NMDA 2C	0	4	1	5
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	4	1	5
Glutamate receptor ionotropic, NMDA 3B	0	4	1	5
Glutamate receptor ionotropic, NMDA 3A	0	4	1	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	5	0	0	5
EWS/FLI fusion protein	16	0	0	16
cytochrome P450 2D6	10	0	0	10
glucocerebrosidase	6	0	0	6
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	3	0	3
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
SMAD family member 2	10	0	0	10
ATAD5 protein, partial	15	0	0	15
Fumarate hydratase	11	0	0	11
SMAD family member 3	10	0	0	10
pregnane X nuclear receptor	30	0	0	30
G	12	0	0	12
polyprotein	11	0	0	11
P53	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
thyroid stimulating hormone receptor	15	0	0	15
activating transcription factor 6	19	0	0	19
peripheral myelin protein 22 isoform 1	19	0	0	19
hemoglobin subunit beta	2	0	0	2
heat shock protein beta-1	13	0	0	13
cytochrome P450 3A4 isoform 1	15	0	0	15
M-phase phosphoprotein 8	8	0	0	8
Bile salt export pump	0	6	0	6
Interferon beta	19	0	0	19
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Inositol hexakisphosphate kinase 1	12	0	0	12
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	9	0	9
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	2	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	12	0	0	12
Chain A, Cruzipain	4	0	0	4
caspase-1 isoform alpha precursor	4	0	0	4
Caspase-7	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	4	0	5
15-lipoxygenase, partial	7	0	0	7
apical membrane antigen 1, AMA1	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
endonuclease IV	10	0	0	10
glp-1 receptor, partial	7	0	0	7
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TSHR protein	1	0	0	1
nonstructural protein 1	5	0	0	5
Parkin	3	0	0	3
LacZ protein (plasmid)	0	1	1	2
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
serine-protein kinase ATM isoform a	3	0	0	3
lysosomal alpha-glucosidase preproprotein	6	0	0	6
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	3	0	0	3
streptokinase A precursor	0	0	3	3
neuropeptide S receptor isoform A	7	0	0	7
Amyloid-beta precursor protein	2	1	0	4
Alpha-synuclein	3	0	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Solute carrier family 15 member 2	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	9	0	0	9
caspase 7, apoptosis-related cysteine protease	4	0	0	4
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
caspase-3	4	0	0	4
Adenylate cyclase type 1	0	2	0	2
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
cytochrome P450 2D6 isoform 1	6	0	0	6
caspase-3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	5	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Transmembrane protease serine 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
5-hydroxytryptamine receptor 4	0	6	0	6
Potassium channel subfamily K member 2	0	1	1	2
Albumin	0	1	3	4
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	2	0	2
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
ATP-dependent translocase ABCB1	0	8	1	20
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	2	5
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	6	0	6
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	4	2	6
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Angiotensin-converting enzyme	0	4	0	4
D(2) dopamine receptor	0	4	0	5
Alpha-1B adrenergic receptor	0	3	0	3
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	4	0	4
D	0	3	0	3
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	8	0	8
Alpha-2B adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	0	4
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	4	0	5
D(4) dopamine receptor	0	3	0	4
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	6	0	6
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Histamine H1 receptor	0	2	1	3
Sodium-dependent serotonin transporter	0	7	0	7
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	4	0	4
D(3) dopamine receptor	0	6	0	7
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	2	0	3
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Histamine H2 receptor	8	0	0	8
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	3	0	3
5-hydroxytryptamine receptor 7	0	3	0	3
Cytochrome P450 2J2	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Sodium-dependent dopamine transporter	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	5	0	5
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	2	0	4
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	2	0	4
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Luciferase	11	0	0	11
PAX8	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
PPM1D protein	4	0	0	4
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	5	0	0	5
steroidogenic factor 1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	3	0	3
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
dopamine D1 receptor	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	4	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Phosphodiesterase	0	3	0	3
Multidrug resistance-associated protein 5	0	1	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	5	0	5
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	2	1	3
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	2	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Cathepsin B	0	1	0	1
Cathepsin B	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
tumor susceptibility gene 101 protein	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	3	0	3
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	2	0	2
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	1	5
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Eyes absent homolog 2	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	2
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
relaxin receptor 1 isoform 1	2	0	0	2
large T antigen	0	1	0	1
Ghrelin O-acyltransferase	0	1	0	1
Monoglyceride lipase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
DNA polymerase beta	4	0	0	4
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	3
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	2	2	4
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	2
G-protein coupled bile acid receptor 1	0	0	1	1
Bile salt export pump	0	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
pyruvate kinase	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Stromelysin-1	0	0	1	1
Urease subunit alpha	0	2	0	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	2	0	2
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	0	1	1
Lysosomal protective protein	0	1	0	1
Fatty acid synthase	0	1	0	1
Liver carboxylesterase	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
[tau protein] kinase	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	1	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	2
Beta-lactamase	0	0	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	2	0	2
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	1	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	2	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	2	0	2
Fatty acid-binding protein, liver	0	0	1	1
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	2	0	2
Aromatase	0	1	0	1
Tissue factor	0	1	0	1
Protein kinase C alpha type	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	3
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Peroxisome proliferator-activated receptor alpha	2	0	2	4
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	2	2	4
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
vasopressin V1b receptor	1	0	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
Chitotriosidase-1	0	3	1	4
Endochitinase B1	0	3	1	4
Olfactory receptor class A-like protein 1	0	0	1	1
Tyrosine-protein kinase Lck	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Histone acetyltransferase KAT8	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Chain A, phosphoenolpyruvate carboxykinase, cytosolic	0	1	0	1
Chain A, Phosphoenolpyruvate Carboxykinase, Cytosolic	0	1	0	1
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
10 kDa chaperonin	0	1	0	1
Chloroquine resistance transporter	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
Quinolone resistance protein NorA	0	1	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
NS5	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Transporter	0	1	0	1
Transporter	0	1	0	1
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Adenine-n6-dna-methyltransferase Taqi	0	0	1	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Ermc' Methyltransferase	0	1	0	1
Chain A, Ermc' Rrna Methyltransferase	0	1	0	1
Chain A, Uroporphyrin-III C-methyltransferase	0	1	0	1
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
tRNA (cytosine(38)-C(5))-methyltransferase	0	1	1	2
Protein arginine N-methyltransferase 5	0	1	0	1
Histone-lysine N-methyltransferase SUV39H1	0	2	0	2
Adenosylhomocysteinase	0	0	0	1
Protein arginine N-methyltransferase 3	0	1	0	1
Indolethylamine N-methyltransferase	0	1	0	1
Histone-lysine N-methyltransferase NSD2	0	1	0	1
Adenosylhomocysteinase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
rRNA adenine N-6-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Nicotinamide N-methyltransferase	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Histone-lysine N-methyltransferase SETDB1	0	1	0	1
Retinoblastoma-binding protein 5	0	1	0	1
Histone-lysine N-methyltransferase EZH2	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N6-adenosine-methyltransferase catalytic subunit	0	1	0	1
Histone-arginine methyltransferase CARM1	0	1	0	1
Histone-lysine N-methyltransferase KMT5C	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Histone-lysine N-methyltransferase EZH1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
Protein arginine N-methyltransferase 1	0	2	0	2
Methylosome protein 50	0	1	0	1
Protein dpy-30 homolog	0	1	0	1
Histamine N-methyltransferase	0	0	0	1
Histone-lysine N-methyltransferase SUV39H2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N-lysine methyltransferase SMYD2	0	1	0	1
Protein arginine N-methyltransferase 7	0	1	0	1
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
Set1/Ash2 histone methyltransferase complex subunit ASH2	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Non-structural protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Thymidine kinase	0	2	0	3
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, PAPAIN	1	0	0	1
WRN	1	0	0	1
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
protein-arginine deiminase type-4	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
chaperonin GroEL	1	0	0	1
Chymotrypsinogen A	0	1	0	1
Cathepsin G	0	1	0	1
Chymotrypsin-like elastase family member 2A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Chymase	0	1	0	1
Cyclin-dependent kinase 8	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Guanine deaminase	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (603)

Protein Targets (1,374)

Spherocytosis, Hereditary

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (603)

Drugs Studied (226)

Protein Targets (1,374)