ascorbic-acid and Pyelonephritis

Topics: Anti-Bacterial Agents; Ascorbic Acid; Child; Child, Preschool; Endoscopy; Female; Humans; Infant; Kidney Function Tests; Male; Methenamine; Methionine; Pyelonephritis; Radiography; Ureter; Ureteral Obstruction; Ureterocele; Urinary Tract Infections; Vesico-Ureteral Reflux

Topics: Adult; Ampicillin; Ascorbic Acid; Bacteriuria; Chronic Disease; Diuresis; Female; Humans; Kidney Failure, Chronic; Male; Prospective Studies; Pyelonephritis; Recurrence; Sulfadimethoxine; Urinary Tract Infections

We studied the spontaneous and metal induced oxidation of lipids and proteins in in vitro modeling ways of lipid peroxidation and blood proteins in the formation of malondialdehyde (MDA) and protein carbonyl groups (PCG) in 86 patients with chronic pyelonephritis (cPN) and 64 patients chronic glomerulonephritis(cGN) without prejudice excretory function of the kidneys. Installed the increase in the blood of patients with cPN MDAs 2 times, MDAe--14%, PCG 1.5 times; and cGN--MDAs 2.3 times, MDAe--29%, PCG--2 times. Found increased MDA content and PCG in the blood of patients with cPN and more expressive when cGN. Stimulation of in vitro peroxidation processes contributed significantly increased of production of MDA comparedwith baseline. In the modeling in vitro ascorbate-dependent and NADPH-dependent lipid peroxidation ways and the increase in protein production of MDA and PCG in both groups of patients, especially in the NADPH-dependent way, which must be considered in the correction of oxidative processes and antioxidant therapy appointment.

Topics: Ascorbic Acid; Case-Control Studies; Chronic Disease; Erythrocytes; Ferrous Compounds; Glomerulonephritis; Humans; Lipid Peroxidation; Malondialdehyde; Primary Cell Culture; Protein Carbonylation; Pyelonephritis

Renal scars have been considered to occur in later stages of chronic pyelonephritis. In our experimental pyelonephritis model, bacteria which possessed mannose-sensitive (MS) pili on the surface promoted renal scarring following inoculation to the renal parenchyma. Polyethylene glycol-modified superoxide dismutase (PEG-SOD) and 2-O-octadecylascorbic acid (CV3611) significantly suppressed scarring when administered orally or parenterally during the early stage of kidney infection with MS-piliated bacteria. These findings suggest that the superoxide and other active oxygens play an important role in renal scarring following infection and that PEG-SOD and CV3611 may be agents capable of preventing renal scarring following bacterial pyelonephritis.

Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Cicatrix; Disease Models, Animal; Drug Resistance; Escherichia coli; Escherichia coli Infections; Female; Fimbriae, Bacterial; Kidney; Mannose; Polyethylene Glycols; Pyelonephritis; Rats; Serratia Infections; Serratia marcescens; Superoxide Dismutase

Topics: Ascorbic Acid; Chronic Disease; Humans; Iodohippuric Acid; Kidney; Kidney Calculi; Organotechnetium Compounds; Pyelonephritis; Radioisotope Renography

A scintigraphic study of the kidneys was carried out in 1780 patients with chronic pyelonephritis: 1308 with calculous and 472 with acalculous pyelonephritis. The scintigraphic finding was interpreted for each kidney separately. Diffuse damages of renal parenchyma was most often observed (47,6%), being, in the majority of the cases--bilateral. Disturbed drainage was established in 13,2%, dysfunction of one of the kidneys--in 18,8% and focal disturbed structure--in 5,4% of the kidneys studied. The results from the scintigraphic study were juxtaposed to the clinic of the disease and the data from laboratory and X-ray investigations. The scintigraphic study of the kidneys with 99m Tc-ascorbic complex is easy to perform, well tolerated by the patients, non-invasive method with no special risks, with minimal irradiation loading. Scintigraphy provides valuable information to the clinicians about the functional, structural and drainage disorders in the kidneys of patients with chronic pyelonephritis, allowing the control of the evolution of the disease and the effect of the treatment.

Topics: Ascorbic Acid; Chronic Disease; Humans; Kidney; Kidney Calculi; Organotechnetium Compounds; Pyelonephritis; Radionuclide Imaging; Technetium

Topics: Animals; Ascorbic Acid; Chronic Disease; Citrates; Drug Therapy, Combination; Hydronephrosis; Hypertension, Renal; Ketoglutaric Acids; Kidney; Malates; Oxidative Phosphorylation; Pyelonephritis; Rats; Solutions; Succinates

Topics: Adult; Aged; Aneurysm; Ascorbic Acid; Female; Glomerular Filtration Rate; Humans; Hydronephrosis; Hypertension, Renal; Iodine Radioisotopes; Iodohippuric Acid; Isotope Labeling; Kidney; Kidney Calculi; Kidney Diseases, Cystic; Kidney Neoplasms; Male; Middle Aged; Pyelonephritis; Quality Control; Radioisotope Renography; Renal Artery; Renal Artery Obstruction; Technetium; Urinary Calculi

Topics: Amniotic Fluid; Ascorbic Acid; Asphyxia Neonatorum; Blood; Blood Group Incompatibility; Diabetes Mellitus; Female; Humans; Infant, Newborn; Injections, Intravenous; Labor, Obstetric; Maternal-Fetal Exchange; Placenta Diseases; Pregnancy; Pregnancy Complications; Pyelonephritis; Rh-Hr Blood-Group System; Umbilical Cord

Topics: Ammonium Chloride; Anti-Infective Agents; Ascorbic Acid; Drug Therapy; Methenamine; Methionine; Nalidixic Acid; Naphthyridines; Nitrofurantoin; Pyelonephritis; Sulfonamides

Topics: Adenosine Triphosphate; Anemia; Anemia, Hemolytic; Ascorbic Acid; Blood Chemical Analysis; Blood Glucose; Carbon Dioxide; Erythrocyte Count; Erythrocytes; Geriatrics; Glucosephosphate Dehydrogenase; Glutathione; Hemoglobinometry; Hemolysis; Kidney Diseases; Metabolism; Methemoglobinemia; Nucleosides; Pyelonephritis; Renal Insufficiency; Sulfamethizole; Sulfathiazoles; Sulfonamides; Toxicology; Urinary Catheterization