Page last updated: 2024-08-05 15:28:29
prosthetic group
A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.
ChEBI ID: 26348
Members (4)
| Member | Definition | Class |
|---|
| 4'-phosphopantetheine | Pantetheine 4'-phosphate with D (R) configuration at the 2' position. | D-pantetheine 4'-phosphate |
| berlition | The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. | (R)-lipoic acid |
| biotin | An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. | biotin |
| flavin-adenine dinucleotide | A flavin adenine dinucleotide in which the substituent at position 10 of the flavin nucleus is a 5'-adenosyldiphosphoribityl group. | FAD |
Research
Studies (19,024)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 4,775 (25.10) | 18.7374 |
| 1990's | 4,056 (21.32) | 18.2507 |
| 2000's | 4,654 (24.46) | 29.6817 |
| 2010's | 4,283 (22.51) | 24.3611 |
| 2020's | 1,256 (6.60) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 111 (0.56%) | 5.53% |
| Reviews | 806 (4.07%) | 6.00% |
| Case Studies | 329 (1.66%) | 4.05% |
| Observational | 1 (0.01%) | 0.25% |
| Other | 18,580 (93.71%) | 84.16% |
Protein Targets (51)
Potency Measurements
Inhibition Measurements
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Chain A, Avidin | Gallus gallus (chicken) | Kd | 0.3000 | 1 | 2 |
| Chain A, Core-streptavidin | Streptomyces avidinii | Kd | 0.0300 | 1 | 16 |
| Chain A, Protein (streptavidin) | Streptomyces avidinii | Kd | 0.0002 | 1 | 1 |
| Chain A, Streptavidin | Streptomyces avidinii | Kd | 0.0000 | 1 | 13 |
| Chain A, Streptavidin Complex With Biotin | Streptomyces avidinii | Kd | 0.0000 | 1 | 1 |
| Chain B, Protein (streptavidin) | Streptomyces avidinii | Kd | 0.0002 | 1 | 1 |
| Chain B, Streptavidin | Streptomyces avidinii | Kd | 0.0000 | 1 | 4 |
| Chain D, Circularly Permuted Core-streptavidin E51/a46 | Streptomyces avidinii | Kd | 0.0439 | 1 | 1 |
| Chain D, Core-streptavidin | Streptomyces avidinii | Kd | 0.0300 | 1 | 16 |
| Chain D, Streptavidin | Streptomyces avidinii | Kd | 0.0000 | 1 | 9 |
| insulin-degrading enzyme isoform 1 | Homo sapiens (human) | EC50 | 2.4495 | 2 | 2 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 2.8000 | 1 | 1 |
| Streptavidin | Streptomyces avidinii | Kd | 0.0000 | 1 | 1 |
Other Measurements