A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
ChEBI ID: 49020
| Member | Definition | Class |
|---|---|---|
| abarelix | A polypeptide compound composed of ten natural and non-natural amino acid resiudes in a linear sequence. | abarelix |
| baicalein | A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. | baicalein |
| bromocriptine | bromocriptine | |
| mifepristone | mifepristone | |
| propylthiouracil | A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. | 6-propyl-2-thiouracil |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,521 (35.53) | 18.7374 |
| 1990's | 4,220 (22.99) | 18.2507 |
| 2000's | 3,594 (19.58) | 29.6817 |
| 2010's | 3,104 (16.91) | 24.3611 |
| 2020's | 916 (4.99) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,460 (7.53%) | 5.53% |
| Reviews | 1,455 (7.51%) | 6.00% |
| Case Studies | 1,888 (9.74%) | 4.05% |
| Observational | 39 (0.20%) | 0.25% |
| Other | 14,536 (75.01%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 13.0965 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 13.1046 | 1 | 2 |
| Androgen receptor | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 9.0622 | 11 | 23 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.1781 | 4 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 23.8668 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 6.9260 | 4 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 15.6341 | 2 | 5 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 11.0792 | 1 | 2 |
| BRCA1 | Homo sapiens (human) | Potency | 10.8820 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 39.2559 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 2.3060 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 6.8534 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 16.3482 | 1 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 25.1189 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 32.4648 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 14.1254 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 2.8294 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 36.0415 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 2.0106 | 2 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 10.1604 | 1 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 2.8294 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 42.0450 | 2 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 4.0871 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.5582 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.4925 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 24.1235 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.7373 | 2 | 3 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 11.6681 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 9.1318 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 41.3055 | 2 | 4 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 6.3455 | 1 | 4 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 1.6373 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 7.9433 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.0575 | 10 | 25 |
| Estrogen receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 2.7224 | 1 | 2 |
| Estrogen receptor beta | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 23.4131 | 10 | 16 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.0432 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 17.2600 | 4 | 10 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 36.3063 | 3 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 26.6320 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 32.3981 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 2.5582 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 8.6706 | 2 | 5 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 38.3366 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 16.1936 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Potency | 0.0008 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.0490 | 3 | 5 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 29.4549 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 1.6784 | 1 | 1 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.1845 | 2 | 5 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 77.9558 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.5582 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 23.7491 | 2 | 4 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.5582 | 1 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 12.1574 | 2 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.8919 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.9241 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 11.9173 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.5252 | 2 | 6 |
| Mineralocorticoid receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 14.1254 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 16.0825 | 3 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 19.5084 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 76.9588 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 31.4585 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 36.1254 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 14.3005 | 5 | 10 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 22.6337 | 5 | 8 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 34.9104 | 1 | 4 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 9.4562 | 1 | 2 |
| polyprotein | Zika virus | Potency | 32.3981 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 29.8154 | 2 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 0.0038 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 25.6198 | 2 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 11.7159 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 28.6478 | 3 | 5 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 13.1070 | 3 | 5 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.8139 | 2 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 34.6167 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 34.6167 | 2 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.1861 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.6249 | 2 | 14 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 14.9047 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 14.3091 | 2 | 6 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 9.4562 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 9.4562 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 22.7985 | 5 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 42.2090 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 43.8669 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 5.3233 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 2.2000 | 1 | 1 |
| 4-aminobutyrate aminotransferase, mitochondrial | Homo sapiens (human) | IC50 | 12,800.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0035 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0240 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0360 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0083 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0053 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5320 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2780 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5320 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.2780 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0220 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0300 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 350.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0150 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5140 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0055 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 13.2475 | 1 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5140 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 6.0490 | 1 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.5200 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5140 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0760 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 16.4500 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | IC50 | 0.2988 | 18 | 21 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 1.1447 | 1 | 2 |
| Androgen receptor | Homo sapiens (human) | Ki | 0.0087 | 6 | 6 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.7633 | 1 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 3.3850 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 6.9350 | 2 | 2 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 4.0600 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 1.3860 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 67.5100 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Chain A, PROGESTERONE RECEPTOR | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 35.0600 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 1.2200 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.2600 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 1.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 16.9500 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 6.6398 | 5 | 5 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 4.7000 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 2.8890 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 1.4440 | 1 | 1 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0016 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0101 | 3 | 4 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0006 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0436 | 2 | 2 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0279 | 2 | 3 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 6.6102 | 8 | 8 |
| Estrogen receptor | Homo sapiens (human) | Ki | 6.7385 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 3.5140 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | Ki | 4.5420 | 3 | 3 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| G protein-coupled receptor kinase 6 | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Genome polyprotein | Zika virus | IC50 | 17.3200 | 2 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.6191 | 52 | 52 |
| Glucocorticoid receptor | Mus musculus (house mouse) | IC50 | 0.0022 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.7740 | 6 | 9 |
| Glucocorticoid receptor | Sus scrofa (pig) | IC50 | 0.0153 | 2 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0149 | 21 | 21 |
| Glucocorticoid receptor | Canis lupus familiaris (dog) | IC50 | 0.0264 | 2 | 2 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0022 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| Gonadotropin-releasing hormone receptor | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 3.2960 | 5 | 5 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 20.0960 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 8.0380 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Linoleate 9S-lipoxygenase-4 | Glycine max (soybean) | IC50 | 22.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | Ki | 4.3300 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 12.5000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 2.5337 | 10 | 13 |
| Mineralocorticoid receptor | Homo sapiens (human) | Ki | 3.8303 | 3 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 83.0610 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.4570 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.9970 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 2.8100 | 1 | 1 |
| NADH-cytochrome b5 reductase 3 | Homo sapiens (human) | IC50 | 279.4000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 50.4250 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 31.5320 | 2 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 33.1800 | 2 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 0.5550 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 51.0929 | 3 | 7 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 0.4579 | 43 | 46 |
| Progesterone receptor | Homo sapiens (human) | Ki | 0.0045 | 13 | 13 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 0.0078 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 75.0002 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase S | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 1.2200 | 9 | 10 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 0.9400 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 22.6000 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK2 | Homo sapiens (human) | IC50 | 314.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 26.2800 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 11.0470 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0015 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 43.5000 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 156.0000 | 2 | 2 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 97.6100 | 2 | 2 |
| Thyroid hormone receptor alpha | Homo sapiens (human) | Ki | 1.2500 | 1 | 1 |
| Thyroid hormone receptor beta | Homo sapiens (human) | Ki | 2.2500 | 1 | 1 |
| Thyroid peroxidase | Homo sapiens (human) | IC50 | 3.3800 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 21.3570 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 5.7000 | 2 | 2 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 291.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 291.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 37.4000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 2.7900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 0.0018 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 1.5849 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | EC50 | 0.0092 | 2 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 0.0158 | 1 | 2 |
| Androgen receptor | Homo sapiens (human) | EC50 | 0.0113 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Kd | 20.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | EC50 | 0.0005 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Kd | 0.0090 | 4 | 5 |
| Estrogen receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 16.5000 | 2 | 2 |
| Genome polyprotein | Zika virus | EC50 | 13.0200 | 2 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | EC50 | 0.7292 | 6 | 6 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0025 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kd | 0.0150 | 1 | 1 |
| Gonadotropin-releasing hormone receptor | Homo sapiens (human) | Kd | 0.0008 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | EC50 | 5.0002 | 2 | 2 |
| Progesterone receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0158 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 2.3150 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 2.9400 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Kd | 18.4000 | 3 | 3 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | EC50 | 2.0000 | 1 | 1 |
| Tegument protein VP16 | Human alphaherpesvirus 1 strain 17 | EC50 | 0.0007 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC150 | 18.9000 | 1 | 1 |
| Cyclic AMP-responsive element-binding protein 1 | Homo sapiens (human) | AC50 | 13.5000 | 1 | 1 |
| dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | AC50 | 14.5280 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | Activity | 0.2700 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 18.9000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kapp | 32.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kif | 0.0020 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | Kif | 0.0100 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | Activity | 0.0013 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | Kif | 0.0118 | 1 | 1 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | Activity | 0.3000 | 1 | 1 |