Any glycine transporter inhibitor that interferes with the action of glycine 1 transporters.
ChEBI ID: 64588
| Member | Definition | Class |
|---|---|---|
| sarcosine | A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine. | sarcosine zwitterion; sarcosine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 444 (29.48) | 18.7374 |
| 1990's | 193 (12.82) | 18.2507 |
| 2000's | 301 (19.99) | 29.6817 |
| 2010's | 459 (30.48) | 24.3611 |
| 2020's | 109 (7.24) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 69 (4.45%) | 5.53% |
| Reviews | 55 (3.55%) | 6.00% |
| Case Studies | 35 (2.26%) | 4.05% |
| Observational | 2 (0.13%) | 0.25% |
| Other | 1,389 (89.61%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 100.0000 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.1836 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.9953 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.9953 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.9953 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 1,900.0000 | 1 | 1 |
| Sodium- and chloride-dependent glycine transporter 1 | Homo sapiens (human) | IC50 | 91.0000 | 1 | 1 |