Page last updated: 2024-09-27

Stretch Marks

Synonyms(1)

Synonym
Stretch Marks

Research Excerpts

Overview

ExcerptReference
"Striae distensae (stretch marks) are a common complication seen in patients on chronic corticosteroid therapy."( Coyle, TE; Desjardins, A; Friedman, HS; Peters, KB; Reardon, DA; Vredenburgh, JJ, 2011)
"Stretch marks are a common disfiguring skin condition that can have a deep psychological impact on affected patients."( Li, Y; Liu, L; Ma, H, 2014)

Research

Studies (68)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (1.47)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's42 (61.76)28.8240
2020's25 (36.76)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low10
allantoin0low20
glycolic acid0medium21
ketoconazole0low10
khellin0low20
metyrapone0low10
minoxidil0low10
oxybutynin0low10
temozolomide0low10
prednisolone0low10
fluocinolone acetonide0low10
trichloroacetic acid0low10
propylparaben0low10
d-alpha tocopherol0low20
methylprednisolone hemisuccinate0low10
erbium0low10
camptothecin0low10
triamcinolone0low10
etoposide0low10
diltiazem0low10
cabergoline0low10
mifepristone0low10
irinotecan0low20
glycyl-histidyl-lysine0low10
rosiglitazone0low10
elastin0medium72
mometasone furoate0low10
tretinoin0medium104
retinol0low20
clindamycin0low10
coenzyme q100low10
clobetasol0low20
fluticasone0low10
boron0low10
ergoline0low10
pasireotide0low10
ubiquinone0low10
ascorbic acid0low70
epidermal growth factor0medium11
dacarbazine0low10

Protein Targets (506)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
RGS121001
GLI family zinc finger 3140014
AR protein160016
estrogen receptor 2 (ER beta)6006
cytochrome P450 family 3 subfamily A polypeptide 4150015
estrogen nuclear receptor alpha170017
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
vitamin D3 receptor isoform VDRA4004
thyroid hormone receptor beta isoform 2110011
Alpha-synuclein1203
Chain A, Beta-lactamase5005
bromodomain adjacent to zinc finger domain 2B4004
geminin110011
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase4004
RAR-related orphan receptor gamma120012
thioredoxin glutathione reductase3003
glucocorticoid receptor [Homo sapiens]140014
retinoic acid nuclear receptor alpha variant 1120012
estrogen-related nuclear receptor alpha140014
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
IDH12002
euchromatic histone-lysine N-methyltransferase 28008
chromobox protein homolog 18008
nuclear factor erythroid 2-related factor 2 isoform 27007
nuclear factor erythroid 2-related factor 2 isoform 19009
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lethal factor (plasmid)3003
lamin isoform A-delta10120012
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0415
Spike glycoprotein5005
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
pregnane X nuclear receptor120012
cytochrome P450 2D69009
thyroid stimulating hormone receptor7007
ATP-binding cassette sub-family C member 3013013
Multidrug resistance-associated protein 4013013
Bile salt export pump014014
Cellular tumor antigen p53110011
5-hydroxytryptamine receptor 2B0718
Canalicular multispecific organic anion transporter 1013014
Histamine H3 receptor0101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, Ferritin light chain3003
Chain A, Cruzipain4004
DNA topoisomerase 0101
thioredoxin reductase9009
15-lipoxygenase, partial2002
ATAD5 protein, partial4004
Fumarate hydratase5005
NFKB1 protein, partial2002
PPM1D protein2002
TDP1 protein140014
Thrombopoietin1001
aldehyde dehydrogenase 1 family, member A17007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
thyroid stimulating hormone receptor7007
regulator of G-protein signaling 44004
EWS/FLI fusion protein5005
polyprotein5005
67.9K protein4004
glucocerebrosidase2002
putative alpha-glucosidase1001
alpha-galactosidase1001
Bloom syndrome protein isoform 13003
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
huntingtin isoform 23003
ras-related protein Rab-9A1001
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase iota isoform a (long)6006
nuclear receptor ROR-gamma isoform 14004
survival motor neuron protein isoform d6006
cytochrome P450 3A4 isoform 18008
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 13003
histone acetyltransferase KAT2A isoform 16006
relaxin receptor 1 isoform 11001
Gamma-aminobutyric acid receptor subunit pi8008
Telomerase reverse transcriptase0101
Serine/threonine-protein kinase Chk10011
Histone deacetylase 30101
Type-2 restriction enzyme ScaI0101
Deoxyribonuclease-2-alpha0101
Tyrosyl-DNA phosphodiesterase 20101
Deoxyribonuclease-10101
Type-2 restriction enzyme PstI0101
Type-2 restriction enzyme EcoRI0101
Prothrombin0002
DNA ligase0101
Interferon beta100010
Integrin beta-32002
Integrin alpha-IIb2002
Heterogeneous nuclear ribonucleoprotein A10011
DNA topoisomerase 10219
DNA topoisomerase 2-alpha0218
Gamma-aminobutyric acid receptor subunit beta-18008
Gamma-aminobutyric acid receptor subunit delta8008
Gamma-aminobutyric acid receptor subunit gamma-28008
Gamma-aminobutyric acid receptor subunit alpha-58008
Gamma-aminobutyric acid receptor subunit alpha-38008
Gamma-aminobutyric acid receptor subunit gamma-18008
Gamma-aminobutyric acid receptor subunit alpha-28008
Type-2 restriction enzyme BamHI0101
Gamma-aminobutyric acid receptor subunit alpha-48008
Gamma-aminobutyric acid receptor subunit gamma-38008
Gamma-aminobutyric acid receptor subunit alpha-68008
Somatostatin receptor type 10202
Somatostatin receptor type 20202
Somatostatin receptor type 40202
Somatostatin receptor type 30202
Somatostatin receptor type 50202
Type-2 restriction enzyme HindIII0101
D(1A) dopamine receptor2002
Histone deacetylase 40101
Ribonuclease pancreatic0101
Gamma-aminobutyric acid receptor subunit alpha-18008
Gamma-aminobutyric acid receptor subunit beta-38008
Gamma-aminobutyric acid receptor subunit beta-28008
Inositol monophosphatase 13003
DNA topoisomerase 2-beta0119
DNA topoisomerase 10102
Histone deacetylase 10101
DNA topoisomerase 10101
Integrase 0202
Histone deacetylase 70101
GABA theta subunit8008
Histone deacetylase 20101
DNA topoisomerase type IB small subunit 0011
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit epsilon8008
Tyrosyl-DNA phosphodiesterase 10101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
Protein-arginine deiminase type-40101
peroxisome proliferator activated receptor gamma8008
aryl hydrocarbon receptor5005
peripheral myelin protein 226006
USP1 protein, partial8008
Microtubule-associated protein tau3003
activating transcription factor 67007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
heat shock protein beta-17007
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 12002
Rap guanine nucleotide exchange factor 31001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
interleukin 82002
hypoxia-inducible factor 1 alpha subunit6006
Matrix metalloproteinase-90101
Isocitrate lyase0101
GLS protein4004
retinoid X nuclear receptor alpha7007
D(1A) dopamine receptor3003
Solute carrier family 22 member 1 0303
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
ATP-dependent translocase ABCB10506
Cytochrome P450 3A4010214
Cytochrome P450 2C9 0628
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1D0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Histamine H2 receptor1001
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20303
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Potassium voltage-gated channel subfamily A member 10101
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
glp-1 receptor, partial6006
SMAD family member 25005
SMAD family member 35005
caspase 7, apoptosis-related cysteine protease2002
nuclear receptor subfamily 1, group I, member 38008
progesterone receptor7007
peroxisome proliferator-activated receptor delta5005
caspase-32002
LMP1 [Human herpesvirus 4]0001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Voltage-dependent calcium channel gamma-2 subunit5005
Regulatory protein E20011
ATP-dependent translocase ABCB10303
Polyunsaturated fatty acid lipoxygenase ALOX150303
DNA topoisomerase 20001
Glutamate receptor 25005
ATP-dependent translocase ABCB10314
UDP-glucuronosyltransferase 1A1 0102
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0012
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Solute carrier organic anion transporter family member 1B30404
Glutamate receptor ionotropic, NMDA 3A0001
Smad32002
nuclear receptor subfamily 1, group I, member 24004
mitogen-activated protein kinase 13003
Glucocorticoid receptor19320
Glycine receptor subunit alpha-10808
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
DNA polymerase kappa isoform 13003
Solute carrier family 15 member 20101
Chain A, Acetylcholinesterase0101
interferon gamma precursor0002
Solute carrier family 22 member 20101
Solute carrier family 22 member 30101
Interstitial collagenase0101
Acetylcholinesterase0101
Muscarinic acetylcholine receptor M40404
Alpha-2C adrenergic receptor0202
Acetylcholinesterase0202
Liver carboxylesterase 10001
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0202
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0303
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20416
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Alpha-2A adrenergic receptor0202
Cytochrome P450 2C80303
Aromatase0303
Steroid 17-alpha-hydroxylase/17,20 lyase 0202
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Cytochrome P450 11B1, mitochondrial0202
Translocator protein0101
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0202
Estrogen receptor0101
Substance-K receptor0202
Sodium-dependent noradrenaline transporter 0404
Thromboxane-A synthase 0202
Histamine H2 receptor0202
Gonadotropin-releasing hormone receptor0112
Sodium-dependent serotonin transporter0202
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Delta-type opioid receptor0202
Cytochrome P450 4F20101
Sodium-dependent dopamine transporter 0404
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0202
Lanosterol 14-alpha demethylase0213
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
GALC protein2002
G6006
cytochrome P450 2D6 isoform 11001
HLA class I histocompatibility antigen, B alpha chain 6006
Cytochrome P450 1A10202
Cytochrome P450 1A20314
Cytochrome P450 2D60213
Cytochrome P450 2C190314
Cytochrome P450 1B10101
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
Luciferase4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Cytochrome P450 11B1, mitochondrial0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
dopamine D1 receptor1001
pregnane X receptor3003
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
nonstructural protein 12002
farnesoid X nuclear receptor4004
atrial natriuretic peptide receptor 2 precursor1001
neuropeptide S receptor isoform A1001
Estrogen receptor1416
Prostaglandin G/H synthase 10101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0429
Tegument protein VP160011
Glucocorticoid receptor0225
Glucocorticoid receptor0112
Mineralocorticoid receptor 1428
Coagulation factor VII0101
Androgen receptor1416
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Tissue factor0101
Androgen receptor0404
5-hydroxytryptamine receptor 1A0202
Prostaglandin G/H synthase 10101
Adenosine receptor A10011
Adenosine receptor A2a0011
Substance-P receptor0101
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Guanine nucleotide-binding protein G2002
Mitogen-activated protein kinase 140101
Progesterone receptor0011
Estrogen receptor beta1416
Sigma non-opioid intracellular receptor 10404
Glucocorticoid receptor0101
ATP-dependent phosphofructokinase3003
phosphopantetheinyl transferase3003
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
TAR DNA-binding protein 431001
isocitrate dehydrogenase 1, partial1001
Caspase-72002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-32002
flap endonuclease 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Solute carrier organic anion transporter family member 1B10202
Amyloid-beta precursor protein0303
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M20112
Muscarinic acetylcholine receptor M10203
Muscarinic acetylcholine receptor M30202
Mu-type opioid receptor0101
D(3) dopamine receptor0202
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Muscarinic acetylcholine receptor0011
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
luciferase0001
Fatty acid-binding protein, liver0101
Corticosteroid-binding globulin0101
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
histone deacetylase 9 isoform 31001
glycogen synthase kinase-3 beta isoform 10011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Nuclear receptor ROR-gamma1113
Disintegrin and metalloproteinase domain-containing protein 171001
CDGSH iron-sulfur domain-containing protein 10101
thyrotropin-releasing hormone receptor2002
Free fatty acid receptor 10011
Glutamate receptor ionotropic, NMDA 2D0011
Glutamate receptor ionotropic, NMDA 3B0011
Carbonic anhydrase 20202
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Tyrosine-protein phosphatase non-receptor type 10101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0101
Cytochrome P450 3A50011
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Catechol O-methyltransferase0011
Peroxisome proliferator-activated receptor alpha0112
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0202
Peroxisome proliferator-activated receptor gamma0225
Peroxisome proliferator-activated receptor gamma0011
C-C chemokine receptor type 20101
Cannabinoid receptor 20011
Carnitine O-palmitoyltransferase 1, liver isoform0101
Mu-type opioid receptor0101
Peroxisome proliferator-activated receptor delta0213
Glutamate receptor ionotropic, NMDA 10011
Peroxisome proliferator-activated receptor alpha0213
ATP-binding cassette sub-family C member 80101
Glutamate receptor ionotropic, NMDA 2A0011
Glutamate receptor ionotropic, NMDA 2B0011
ATP-sensitive inward rectifier potassium channel 110101
Glutamate receptor ionotropic, NMDA 2C0011
Thrombin 0011
CDGSH iron-sulfur domain-containing protein 20101
Glutamate receptor ionotropic, NMDA 3A0011
CDGSH iron-sulfur domain-containing protein 10202
polyadenylate-binding protein 10101
Carbonic anhydrase 120101
Tyrosine-protein kinase ABL10101
Carbonic anhydrase 10101
Tyrosine-protein kinase ABL20101
Carbonic anhydrase 90101
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Parkin1001
thyroid hormone receptor beta isoform a1001
Ornithine decarboxylase0001
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Alpha-1A adrenergic receptor0202
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
arylsulfatase A1001
procathepsin L isoform 1 preproprotein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]