Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Reference |
|---|
| "Insulin resistance is seen in several pathophysiological conditions, such as obesity, diabetes mellitus, and essential hypertension." | ( Vaaler, S, 1992) |
| "4." | ( Berntorp, K; Lindgärde, F; Mattiasson, I, 1992) |
| "Insulin resistance is a major determinant of the plasma insulin concentration." | ( Crook, D; Godsland, IF; Walton, C; Wynn, V, 1992) |
| "Peripheral insulin resistance is a feature of essential hypertension, but there is little information about hepatic insulin sensitivity." | ( Atkinson, AB; Bell, NP; Bell, PM; Ennis, CN; Neely, RD; Rooney, DP; Sheridan, B; Trimble, ER, 1992) |
| "Insulin resistance is independent of the etiology of liver cirrhosis and of the clinical and nutritional state of the patient." | ( Balks, HJ; Bürger, M; Fenk, A; Lautz, HU; Müller, MJ; Rieger, A; Schmidt, FW; Selberg, O; von zur Mühlen, A; Willmann, O, 1992) |
| "To determine if insulin resistance is an inherited characteristic in this group, we performed oral glucose tolerance tests (OGTT) on first-degree relatives, 21 parents and 17 siblings, of patients with FA." | ( Andermann, E; Fantus, IG; Janjua, N; Senni, H, 1991) |
| "Thus, when insulin resistance is present, the activity of these pumps in the smooth muscle of the arterial wall might be reduced." | ( Flack, JM; Sowers, JR, 1991) |
| "Insulin resistance is frequently associated with acanthosis nigricans and hyperandrogenism." | ( Cama, A; de la Luz Sierra, M; Gorden, P; Imperato-McGinley, J; Kadowaki, T; Ottini, L; Taylor, SI, 1991) |
| "Insulin resistance is accentuated during periods of poor metabolic control in human non-insulin-dependent diabetes mellitus." | ( Hager, SR; Jochen, AL; Kalkhoff, RK, 1991) |
| "Insulin resistance is a critical component underlying the altered glucose homeostasis in a variety of metabolic and non-metabolic disorders." | ( Alleman, Y; Ferrari, P; Riesen, W; Shaw, S; Weidmann, P, 1991) |
| "Muscle and hepatic insulin resistance are two major defects of non-insulin-dependent diabetes mellitus." | ( Chisholm, DJ; Clark, PW; Daley, EA; Jenkins, AB; Kraegen, EW; Storlien, LH, 1991) |
| "The insulin resistance is due to reduced cellular insulin binding because of a lack of or defective binding sites and/or because the interaction with the tyrosine kinase of the beta-subunit is hindered." | ( Froesch, ER; Schoenle, EJ; Torresani, T; Werder, EA; Zachmann, M; Zenobi, PD, 1991) |
| "Insulin resistance is commonly associated with obesity and noninsulin-dependent diabetes." | ( Bogardus, C; Knowler, WC; Lillioja, S; Nyomba, BL; Ravussin, E; Raz, I; Saad, MF; Swinburn, BA; Zurlo, F, 1991) |
| "We conclude that insulin resistance is associated with a reduced risk of weight gain in nondiabetic Pima Indians." | ( Bogardus, C; Knowler, WC; Lillioja, S; Nyomba, BL; Ravussin, E; Raz, I; Saad, MF; Swinburn, BA; Zurlo, F, 1991) |
| "Insulin resistance is the key in this process because of the inability of insulin to suppress hepatic glucose production, thereby allowing an unopposed glucagon effect." | ( Caro, JF, 1990) |
| "In vivo insulin resistance is a characteristic of the liver and peripheral tissues in 10-wk-old female rats with non-insulin-dependent diabetes induced by streptozotocin given on day 5 after birth." | ( Blondel, O; Chevalier, B; Portha, B; Simon, J, 1990) |
| "Insulin resistance is one of pathogenic factors for non-insulin-dependent diabetes mellitus (NIDDM)." | ( Fujita, T; Ikeda, H; Shimura, Y; Sugiyama, Y; Taketomi, S, 1990) |
| "Peripheral insulin resistance is a common finding in hypertriglyceridemia." | ( Andrews, WJ; Bell, PM; Henry, RW; McKane, WR; Stevens, AB; Woods, R, 1990) |
| "We conclude that insulin resistance is present in both essential hypertensive and overweight subjects." | ( Marigliano, A; Melis, A; Orecchioni, C; Pala, A; Sechi, LA; Tedde, R, 1990) |
| "Insulin resistance is mainly due to a reduction in glucose uptake by muscle tissue." | ( Koivisto, VA; Yki-Järvinen, H, 1990) |
| "Insulin resistance is associated with hyperandrogenic states." | ( Aiman, EJ; Drucker, WD; Kissebah, AH; Peiris, AN, 1989) |
| "Thus, insulin resistance is no general phenomenon, but is confined to specific effector systems." | ( Bosman, J; Koopmans, SJ; Krans, HM; Radder, JK; Sips, HC, 1989) |
| "This insulin resistance is associated with a very low rate of lipogenesis and low activities of acetyl-CoA carboxylase, fatty acid synthase and pyruvate dehydrogenase." | ( Baudon, MA; Ferré, P; Girard, J; Issad, T; Pastor-Anglada, M, 1989) |
| "Insulin resistance is universal among children with end-stage renal disease and may be caused by uremic toxins accumulated because of reduced renal function." | ( Mak, RH, 1989) |
| "The insulin resistance is due to beta-adrenergic stimulation and can be prevented by propranolol." | ( Attvall, S; Fowelin, J; Lager, I; Smith, U; von Schenck, H, 1987) |
| "In vitro, severe insulin resistance is reflected by a low level of insulin stimulated uptake of 2-deoxyglucose by these fibroblasts." | ( Beemer, FA; Klinkhamer, MP; Krans, HM; Lindhout, D; Maassen, JA; Möller, W; Sips, H; van der Zon, GC, 1988) |
| "Insulin resistance is associated with obesity, but is also familial, independent of obesity." | ( Bogardus, C; Lillioja, S, 1988) |
| "In vitro, severe insulin resistance is reflected by a low level of insulin binding to the patients fibroblasts and impaired insulin-mediated uptake of 2-deoxyglucose." | ( Klinkhamer, MP; Krans, HM; Maassen, JA; Möller, W; Odink, RJ; Sips, H; van der Zon, GC; Wieringa, T, 1988) |
| "This prolonged insulin resistance is largely related to release of growth hormone and cortisol." | ( Blackard, WG; Brennan, JR; Clore, JN; Gebhart, SP; Nestler, JE; Newsome, HH, 1987) |
| "Insulin resistance is a classic characteristic of type II diabetes." | ( Ader, M; Bergman, RN, 1987) |
| "Insulin resistance is a postinsulin receptor kinase defect possibly due to lack of the generation of the chemical mediator of insulin action." | ( Brancaccio, D; Caro, JF; Folli, F; Sinha, MK, 1986) |
| "Insulin resistance is frequently observed in obese subjects." | ( Felber, JP; Henny, C; Jéquier, E; Meylan, M; Temler, E, 1987) |
| "Insulin resistance is characteristic of the diabetic state." | ( DeFronzo, RA; Papachristou, D; Rossetti, L; Shulman, GI; Smith, D, 1987) |
| "Insulin resistance is apparently a common feature of type I diabetes at serum insulin concentrations of approximately 100 microU/ml." | ( Arias, P; Fussgänger, R; Kerner, W; Navascués, I; Pfeiffer, EF; von Schrenck, T, 1985) |
| "Insulin resistance is a prominent feature of three clinical conditions: obesity, impaired glucose tolerance, and non-insulin-dependent (type II) diabetes mellitus." | ( Livingston, JN; Lockwood, DH; Truglia, JA, 1985) |
| "Insulin resistance is well established in Cushing's syndrome, but its mechanisms are not completely understood." | ( Armoni, M; Barzilai, D; Barzilai, N; Cohen, P; Ish-Shalom, Z; Karnieli, E; Rafaelov, R, 1985) |
| "The insulin resistance is due to both receptor and postreceptor perturbations." | ( Lönnroth, P; Smith, U, 1986) |
| "Insulin resistance is a well-known phenomenon in diabetic patients." | ( Bratusch-Marrain, P; Waldhäusl, W, 1985) |
| "Insulin resistance is evident in several clinical conditions such as obesity, diabetes type II, hypercortisolism." | ( Lager, I; Lönnroth, P, 1983) |
| "This state of insulin resistance is similar to that seen with the human autoantibodies." | ( Grunfeld, C, 1984) |
| "Insulin resistance is a hallmark of post-traumatic metabolism." | ( Aoki, TT; Bessey, PQ; Black, PR; Brooks, DC; Wilmore, DW, 1984) |
| "Insulin resistance is a characteristic feature of both obesity and noninsulin-dependent diabetes mellitus." | ( Kolterman, OG; Olefsky, JM, 1981) |
| "Obesity-associated insulin resistance is probably due to a decrease in number of insulin receptors, induced by hyperinsulinemia." | ( Berchtold, P; Berger, M; Gries, FA; Zimmermann, H, 1980) |
| "So-called insulin resistance is a frequent phenomenon and a marker of increased risk for both type II diabetes mellitus and atherosclerosis." | ( Jacob, S; Rett, K; Wicklmayr, M, 1994) |
| "Insulin resistance is an important metabolic abnormality often associated with infections, cancer, obesity, and especially non-insulin-dependent diabetes mellitus (NIDDM)." | ( Budavari, A; Hotamisligil, GS; Murray, D; Spiegelman, BM, 1994) |
| "Insulin resistance is a common clinical feature of obesity and non-insulin-dependent diabetes mellitus, and is characterized by elevated serum levels of glucose, insulin, and lipids." | ( Balba, Y; Donnelly, PV; Knutson, VP; Lopez-Reyes, M, 1995) |
| "Insulin resistance is a major feature of noninsulin-dependent diabetes mellitus." | ( Goldfine, ID; Maddux, BA; Moller, DE; Reaven, GM; Sbraccia, P, 1993) |
| "Whether insulin resistance is causally related to the muscle disorder awaits to be clarified." | ( Bjørbaek, C; Hansen, T; Klein, HH; Müller, J; Pedersen, O; Røder, ME; Skovby, F; Vestergaard, H, 1995) |
| "Insulin resistance is part of the so-called plurimetabolic syndrome where it was observed in association with various signs among which the association with impaired serum lipids is very frequent." | ( Skrha, J, 1995) |
| "Insulin resistance is one of the key features of non-insulin-dependent diabetes mellitus (NIDDM)." | ( Freund, P; Kühnle, HF; Wolff, HP, 1995) |
| "Insulin resistance is elevated in hypertensive patients and it has been thought responsible for or associated with other metabolic abnormalities." | ( Cuspidi, C; Leonetti, G, 1995) |
| "Insulin resistance is associated with hypertriglyceridemia and elevated free fatty acid (FFA) concentrations in obese and diabetic individuals, but it is unclear to what extent this relationship is independent of obesity and is present in healthy individuals." | ( Bruce, R; Crook, D; Godsland, I; Walton, C; Wynn, V, 1994) |
| "The result of the insulin resistance is an increase in plasma glucose levels, and hyperinsulinemia, which overcomes insulin resistance, returning glucose turnover to normal despite continuing AII infusion." | ( Rao, RH, 1994) |
| "Insulin resistance is present in liver and muscle of subjects with type 2 diabetes and obesity." | ( Colca, JR; Kurowski, TG; Ruderman, NB; Saha, AK, 1994) |
| "Insulin resistance is associated with a number of risk factors for atherosclerosis, including glucose intolerance, hypertension, and dyslipidemia." | ( Bell, DS, 1993) |
| "Insulin resistance is also present after elective surgical treatment, more pronounced with increasingly greater magnitude of operation performed." | ( Efendic, S; Gutniak, M; Häggmark, T; Ljungqvist, O; Thorell, A, 1994) |
| "Insulin resistance is a major risk factor for the development of NIDDM: A low acute insulin response to glucose is an additional but weaker risk factor." | ( Bennett, PH; Bogardus, C; Ferraro, R; Foley, JE; Knowler, WC; Lillioja, S; Mott, DM; Ravussin, E; Spraul, M, 1993) |
| "4." | ( Altomonte, F; Baldi, S; Brandi, LS; Ferrannini, E; Frascerra, S; Natali, A; Santoro, D, 1993) |
| "Insulin resistance is present in the great majority of patients with states of glucose intolerance, but frank decompensation of glucose homoeostasis does not occur if individuals can maintain a state of compensatory hyperinsulinaemia." | ( Laws, A; Reaven, GM, 1993) |
| "Insulin resistance is present in patients suffering from lipoatrophic syndromes long before the onset of diabetes mellitus." | ( Capeau, J; Chevenne, D; Cochet, I; Darmaun, D; Foussier, V; Magre, J; Rakotoambinina, B; Robert, JJ, 1993) |
| "Insulin resistance is commonly associated with obesity." | ( Bak, JF; Børglum, JD; Pedersen, SB; Richelsen, B; Schmitz, O; Sørensen, NS, 1993) |
| "Insulin resistance is prevalent in healthy postmenopausal women." | ( Ditkoff, EC; Lindheim, SR; Lobo, RA; Presser, SC; Stanczyk, FZ; Vijod, MA, 1993) |
| "Insulin resistance is found in association with obesity, non-insulin-dependent diabetes mellitus, and essential hypertension, which are all risk factors for atherosclerotic cardiovascular disease." | ( Boni, C; Buzzigoli, G; Ferrannini, E; Galvan, AQ; Masoni, A; Natali, A; Sampietro, T; Santoro, D, 1993) |
| "In this regard, insulin resistance is of additional predictive value for ovarian volume and stroma echogenicity." | ( de Jong, FH; Fauser, BC; Hop, WC; Pache, TD, 1993) |
| "Insulin resistance is restricted to glucose, but not to amino acid metabolism." | ( Biolo, G; Inchiostro, S; Orlando, R; Sergi, G; Tessari, P; Vettore, M, 1993) |
| "Insulin resistance is a major factor in the pathophysiology of type II diabetes and a major impediment to successful therapy." | ( Clemmons, DR; Morrow, LA; Moses, AC; O'Brien, M; Young, SC, 1996) |
| "Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM)." | ( Boden, G; Chaiken, RL; Eckert-Norton, M; Gelfand, RA; Lebovitz, HE; Pasmantier, R; Ryan, I, 1995) |
| "The persistent insulin resistance is not associated with increased lipid oxidation but is associated with hyperinsulinemia and reduced insulin-mediated muscle glycogen synthesis." | ( Hettiarachchi, M; Ho, KK; Jenkins, AB; Kraegen, EW; Theos, V; Watkinson, A, 1996) |
| "Insulin resistance is directly proportional to the degree of glycaemic control in patients with insulin-dependent or non-insulin-dependent diabetes mellitus (IDDM and NIDDM) in whom hyperglycaemia induces insulin resistance within 24 hours." | ( Yki-Järvinen, H, 1996) |
| "Thus, obesity/insulin resistance is associated with (a) blunted endothelium-dependent, but normal endothelium-independent vasodilation and (b) failure of euglycemic hyperinsulinemia to augment endothelium-dependent vasodilation." | ( Baron, AD; Brechtel, G; Chaker, H; Johnson, A; Leaming, R; Steinberg, HO, 1996) |
| "Insulin resistance is largely inherited, in rare cases as a monogenic disorder or more commonly as a complex trait." | ( Bjørbaek, C; Moller, DE; Vidal-Puig, A, 1996) |
| "Insulin resistance is obviously a strong predictive factor for NIDDM, but it is not sufficient for the development of overt diabetes." | ( Kuehnle, HF, 1996) |
| "Insulin resistance is frequently associated with abdominal obesity, and probably plays an important role in the pathophysiology of hypertriglyceridaemia, low levels of plasma high-density lipoprotein (HDL)-cholesterol, hypertension and reduced fibrinolytic activity." | ( Buemann, B; Tremblay, A, 1996) |
| "Insulin resistance is a predictor of the development of noninsulin-dependent diabetes mellitus (NIDDM) in humans." | ( Ossowski, V; Pratley, R; Thompson, DB, 1996) |
| "Thus, even though insulin resistance is presumably to some extent genetically determined, these results suggest that considering psychosocial stress may be beneficial in understanding IRS risk-factor clustering." | ( Adlercreutz, H; Hautanen, A; Keltikangas-Järvinen, L; Räikkönen, K, 1996) |
| "Insulin resistance is a feature of the polycystic ovary syndrome (PCOS)." | ( Falcone, T; Morris, DV, 1996) |
| "Insulin resistance is a manifestation of both diabetes mellitus and obesity." | ( Frost, SC; Thomson, MJ; Williams, MG, 1997) |
| "Thus, fat-induced insulin resistance is associated with: (a) decreased skeletal muscle Glc-6-P levels indicating defective transport/phosphorylation of glucose; (b) marked accumulation of the endproducts of the hexosamine biosynthetic pathway preceding the onset of insulin resistance." | ( Barzilai, N; Chen, W; Hawkins, M; Hu, M; Liu, R; Rossetti, L, 1997) |
| "To know whether the insulin resistance is improved by delaying carbohydrate absorption from the small intestine, we studied the effect of a disaccharidase inhibitor, AO-128, on insulin resistance of Wistar fatty rats." | ( Abe, T; Eguchi, H; Igarashi, K; Igarashi, M; Kimura, M; Manaka, H; Sasaki, H; Sugiyama, K; Tominaga, M, 1997) |
| "Insulin resistance is a precursor to and primary cause of Type 2 diabetes mellitus." | ( Bergman, RN, 1997) |
| "Insulin resistance is a potential target for pharmacologic intervention in non-insulin-dependent diabetes." | ( Anichini, R; Ferrannini, E; Foot, E; Gastaldelli, A; Pecori, N; Seghieri, G; Sironi, AM; Vichi, S, 1997) |
| "Insulin resistance is common in patients with angina pectoris, a positive exercise electrocardiogram, and normal coronary angiograms (syndrome X)." | ( Bagger, JP; Botker, HE; Moller, N; Nielsen, TT; Schmitz, O, 1997) |
| "1." | ( Buckingham, RE; Dores, J; Savage, MW; Walker, AB; Williams, G, 1997) |
| "Insulin resistance is associated with both obesity and hypertension." | ( Bedol, D; Ernsberger, P; Farrell, CJ; Friedman, JE; Ishizuka, T; Kaung, HL; Koletsky, RJ; Liu, S, 1997) |
| "Insulin resistance is a common syndrome that often precedes the development of noninsulin-dependent diabetes mellitus (NIDDM)." | ( Attie, AD; Cartee, GD; Dumke, C; Ranheim, T; Schueler, KL, 1997) |
| "The FFA induced insulin resistance is physiologically important during starvation by preserving carbohydrate for oxidation in the central nervous system and during pregnancy, where the well recognized accelerated starvation pattern provides carbohydrate for the growing fetus." | ( Boden, G, 1998) |
| "Insulin resistance is associated with diabetes." | ( Buse, MG; Chen, H; Feagin, AC; Ing, BL; Quon, MJ; Robinson, KA, 1997) |
| "Insulin resistance is associated with an increased risk of cardiovascular disease that is probably related to abnormalities of vascular wall function." | ( Davidge, ST; McKendrick, JD; O'Brien, SF; Radomski, MW; Russell, JC, 1998) |
| "Insulin resistance is associated with a predominance of small, atherogenic LDL particles that are more prone to oxidative modification." | ( Demacker, PN; Smits, P; Stalenhoef, AF; Tack, CJ, 1998) |
| "Insulin resistance is associated with a decreased vasodilator response to insulin." | ( Lutterman, JA; Ong, MK; Smits, P; Tack, CJ, 1998) |
| "Insulin resistance is an important mechanism in the development of the insulin resistance syndrome and type 2 diabetes." | ( Eriksson, KF; Groop, L; Nilsson, P, 1998) |
| "Insulin resistance is present in nearly all patients with cirrhosis, but its etiology remains unknown." | ( Bush, AJ; Lambeth, H; Matthews, DE; Petrides, AS; Stanley, T; Vogt, C, 1998) |
| "Insulin resistance is associated with hyperleptinemia, whilst exposure of hepatoma cells and isolated adipocytes to high concentrations of leptin has been demonstrated to result in attenuated insulin response and a reduced suppression of gluconeogenesis." | ( Arch, J; Buckingham, R; Pickavance, L; Tadayyon, M; Upton, R; Widdowson, PS; Williams, G, 1998) |
| "This shows that insulin resistance is accompanied by a general islet supersensitivity to non-glucose stimuli, which persists over a long period of time." | ( Ahrén, B; Simonsson, E, 1998) |
| "Insulin resistance is common in the general population and tends to cluster with glucose intolerance, dyslipidaemia and high blood pressure." | ( Ferrannini, E; Mari, A, 1998) |
| "Insulin resistance is inherited as a non-mendelian trait." | ( Accili, D; Castle, AL; Ebina, Y; Hayashi, H; Kido, Y; Lauro, D; Zarnowski, MJ, 1998) |
| "Insulin resistance is a part of the metabolic cardiovascular syndrome." | ( Fossum, E; Høieggen, A; Kjeldsen, SE; Moan, A; Nordby, G; Rostrup, M, 1998) |
| "Since insulin resistance is a polygenic disorder, the two basic genetic approaches we follow is to identify genetic defects of insulin action in cells of patients with inherited syndromes of insulin resistance and to characterize molecular mechanisms of insulin regulated gene expression." | ( Knebel, B; Kotzka, J; Krone, W; Müller-Wieland, D, 1998) |
| "Skeletal muscle insulin resistance is among the earliest detectable defects in humans with type 2 diabetes mellitus." | ( Accili, D; Brüning, JC; Goodyear, LJ; Hayashi, T; Hörsch, D; Kahn, CR; Michael, MD; Winnay, JN, 1998) |
| "While insulin resistance is common in older people, large numbers also have impaired insulin secretion." | ( Morley, JE, 1998) |
| "Insulin resistance is characterized by impaired responsiveness to endogenous or exogenous insulin." | ( Fonseca, VA; Granberry, MC, 1999) |
| "Insulin resistance is established as the characteristic pathologic feature of patients with glucose intolerance and NIDDM describing a state in which insulin stimulated glucose uptake and utilisation in liver, skeletal muscle and adipose tissue is impaired and coupled to impaired suppression of hepatic glucose output." | ( Clapham, JC; Turner, NC, 1998) |
| "Insulin resistance is associated not only with the classic cardiovascular risk factors of hypertension and dyslipidemia, but also with several disorders of coagulation and fibrinolysis." | ( Yudkin, JS, 1999) |
| "Insulin resistance is not associated with the overproduction of TG in this animal model for obesity." | ( Adachi, M; Hirano, T; Inoue, S; Miura, M; Namba, Y; Osaka, T; Suga, A; Tsuji, M, 1999) |
| "Insulin resistance is an early and major feature in the development of non-insulin-dependent diabetes mellitus(NIDDM)." | ( Kotake, H; Oikawa, S, 1999) |
| "Insulin resistance is one of the cardinal pathophysiological components of the metabolic syndrome, type 2 diabetes, and frequently co-exists with essential hypertension." | ( Caro, JF; Kolaczynski, JW, 1998) |
| "Insulin resistance is central to the pathophysiology of type 2 diabetes." | ( Le Marchand-Brustel, Y, 1999) |
| "Hypertension and insulin resistance are often part of a complex set of abnormalities including obesity, hyperlipidemia, and glucose intolerance, described as syndrome X." | ( Bedol, D; Ernsberger, P; Farrell, CJ; Friedman, JE; Ishizuka, T; Koletsky, RJ; Liu, S, 1998) |
| "The insulin resistance is associated with a clustering of risk factors of cardiovascular disease, more cluste-ring, more resistant." | ( Guo, D; Xu, C, 1997) |
| "Insulin resistance is the best prediction factor for the clinical onset of type 2 diabetes." | ( Arcelloni, C; Battezzati, A; De Cobelli, F; Del Maschio, A; Luzi, L; Pagliato, E; Perseghin, G; Pozza, G; Scifo, P; Testolin, G; Vanzulli, A, 1999) |
| "Insulin resistance is a feature common to patients with diabetes and to some with hypertension." | ( Bellini, C; De Mattia, G; Desideri, G; Ferri, C; Hollenberg, NK; Santucci, A; Valenti, M; Williams, GH, 1999) |
| "The relief of insulin resistance is one of the two therapeutic targets of the treatment of type 2 diabetes." | ( Andres, E; Blicklé, JF; Brogard, JM; Neyrolles, N, 1999) |
| "Insulin resistance is a major component of type 2 diabetes; therefore, an insulin sensitizer agent like the thiazolidinedione compound troglitazone is considered a very promising drug." | ( Lefèbvre, PJ; Scheen, AJ, 1999) |
| "Insulin resistance is associated with atherogenic lipoprotein phenotype, including small dense LDL particle, hypertriglycemia and low HDL cholesterol levels." | ( Daida, H; Mokuno, H; Ohmura, H; Sawano, M; Shimada, K; Sunayama, S; Watanabe, Y; Yamaguchi, H, 1999) |
| "Insulin resistance is present also in strains of rats with genetic hypertension that can be utilized as models to study the molecular mechanisms of this abnormality." | ( Sechi, LA, 1999) |
| "Since insulin resistance is thought to play a role in raising blood pressure, we investigated sex differences in leptin concentrations between hypertensive and normotensive individuals." | ( Chen, YT; Lee, WJ; Sheu, WH, 1999) |
| "Obesity and insulin resistance are strongly associated with an increased risk of vascular disease." | ( Davidge, ST; O'Brien, SF; Russell, JC, 1999) |
| "Denervation-induced insulin resistance is reversed by intraportal but not intravenous administration of acetylcholine or SIN-1." | ( Lautt, WW, 1999) |
| "Insulin resistance is instrumental in pathogenesis of type 2 diabetes mellitus and involves decreased glucose transport activity in these tissues." | ( Kurokawa, K; Oka, Y, 2000) |
| "Insulin resistance is associated with many common diseases including diabetes mellitus, hyperlipidemia and hypertension, and plays an important role for determining their clinical courses." | ( Hamaguchi, T; Hanafusa, T; Matsuzawa, Y; Nakajima, H, 2000) |
| "Insulin resistance is thought to lead to overproduction of very low-density lipoprotein (VLDL) cholesterol through the decreased peripheral lipoprotein lipase (LPL) activity, increased production of apolipoprotein B-100 and decreased clearance of remnant particles." | ( Mabuchi, H; Yagi, K, 2000) |
| "Insulin resistance is not the only underlying factor for the clustering of CVD risk factors in south Indians." | ( Ramachandran, A; Satyavani, K; Sivasankari, S; Snehalatha, C; Vijay, V, 2000) |
| "Myocardial insulin resistance is not an inherent consequence of whole body insulin resistance." | ( Bøtker, HE; Bøttcher, M; Christiansen, JS; Gjedde, A; Nielsen, TT; Schmitz, O; Wiggers, H, 2000) |
| "Insulin resistance is followed by an islet adaptation resulting in a compensating increase in insulin secretion and hyperinsulinemia." | ( Ahrén, B; Karlsson, S; Simonsson, E, 2000) |
| "Insulin resistance is known to unite several metabolic abnormalities." | ( Daida, H; Sunayama, S; Watanabe, Y; Yamaguchi, H, 2000) |
| "Insulin and insulin resistance are associated to high blood leptin levels and this association is independent of the degree of adiposity and body fat distribution." | ( Albala, C; Arroyo, P; Díaz, E; Díaz, J; Pérez, F; Santos, JL; Yáñez, M, 2000) |
| "The presence of insulin resistance is frequently found in essential hypertension." | ( Haas, T; Hilgertová, J; Prázný, M; Sindelka, G; Skrha, J; Widimský, J, 2000) |
| "Insulin resistance is associated with major risk factors for atherosclerosis." | ( Hirai, N; Hirashima, O; Kawano, H; Kugiyama, K; Moriyama, Y; Motoyama, T; Nakao, K; Ogawa, H; Sakamoto, T; Yasue, H, 2000) |
| "Insulin resistance is known to be closely related to essential hypertension." | ( Nakamura, M; Ohno, Y; Saruta, T; Suzuki, H; Yamakawa, H, 2000) |
| "Insulin resistance is the predominant early pathological defect in Type 2 diabetes." | ( Murphy, E; Nolan, JJ, 2000) |
| "Insulin resistance is frequently associated with this trait." | ( Henry, RR; Kailasam, MT; O'Connor, DT; Parmer, RJ; Tyrell, EA, 2000) |
| "Insulin resistance is associated with advanced and moderate chronic renal failure (CRF)." | ( Hayashi, M; Kato, Y; Ohno, Y; Saruta, T; Sasaki, T; Suzawa, T, 2000) |
| "Insulin resistance is the major defect in type 2 diabetes." | ( Ducobu, J; Sternon, J, 2000) |
| "Insulin resistance is of pathogenic importance in several common human disorders including type 2 diabetes, hypertension, obesity and hyperlipidemia, but the underlying mechanisms are unknown." | ( Aitman, TJ; Collison, M; Connell, JM; Dominiczak, AF; Dominiczak, MH; Glazier, AM; Gould, GW; Graham, D; Morton, JJ, 2000) |
| "Women with severe insulin resistance are a unique subset of polycystic ovary syndrome." | ( Barbieri, RL, 2000) |
| "Also, insulin resistance is a stronger risk factor than is body mass index or testosterone for SDB in PCOS women." | ( Bixler, EO; Chrousos, GP; Grayev, A; Kales, A; Legro, RS; Vgontzas, AN, 2001) |
| "Insulin resistance is associated with atherosclerosis, and hyperinsulinemia is predictive of coronary heart disease." | ( Bergerone, S; Cassader, M; Cavallo-Perin, P; Comune, M; Gagnor, A; Giunti, S; Pacini, G; Pagano, G, 2001) |
| "Insulin resistance is the cornerstone of metabolic syndrome X, with secondary hyperinsulinism." | ( Daubresse, JC, 2000) |
| "Insulin resistance is a characteristic feature of type 2 diabetes and obesity." | ( Johnson, WT; Stephens, TW; Yakubu-Madus, FE, 2000) |
| "Insulin resistance is thought to be the primary defect in the pathophysiology of type 2 diabetes." | ( Baumann, CA; Saltiel, AR, 2001) |
| "Vascular insulin resistance is a type of endothelial dysfunction which impairs the insulin modulation of the vascular effects of sympathetic nervous activation." | ( Argenziano, L; Fratta, L; Pompeo, F; Trimarco, B; Vecchione, C, 2000) |
| "Insulin resistance is a change in physiologic regulation such that a fixed dose of insulin causes less of an effect on glucose metabolism than occurs in normal individuals." | ( Banerji, MA; Lebovitz, HE, 2001) |
| "Postoperative insulin resistance is a well-characterized metabolic state that has been shown to correlate with the length of postoperative stay in hospital." | ( Ljungqvist, O; Myrenfors, P; Nygren, J; Soop, M; Thorell, A, 2001) |
| "Insulin resistance is known as an important risk factor for coronary artery disease (CAD)." | ( Fukae, S; Kizaki, Y; Matsumoto, K; Miyake, S; Sera, Y; Tomihira, M; Tominaga, T; Ueki, Y, 2001) |
| "Insulin resistance is an important risk factor for the development of hypertension, atherosclerotic heart disease, left ventricular hypertrophy and dysfunction, and heart failure." | ( Anker, S; Anker, SD; Coats, AJ, 2000) |
| "Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response." | ( Cefalu, WT, 2001) |
| "Insulin resistance is an important determinant of circulating leptin concentrations in humans, but its independent contribution on plasma leptin levels are controversial." | ( Fernández-Castañer, M; Gómez, JM; Molina, A; Soler, J, 2001) |
| "Insulin resistance is a hallmark of the development of type 2 diabetes." | ( Chang, CT; Chen, CC; Chen, RH; Sheen, LY; Shih, HC; Wang, HJ; Wang, TY, 2001) |
| "Insulin resistance is a feature of many common disorders including obesity and type 2 diabetes mellitus." | ( Flier, SN; Kahn, CR; Kulkarni, RN, 2001) |
| "Insulin resistance is associated with accelerated atherosclerosis, especially coronary heart disease." | ( Aso, Y; Fujiwara, Y; Inukai, T; Takanashi, K; Takemura, Y; Tayama, K, 2001) |
| "Insulin resistance is a central feature of the metabolic response after elective surgery as well as other trauma, and has been shown to be a predictor of the length of stay after surgery." | ( Ljungqvist, O; Nygren, J; Thorell, A, 2001) |
| "Insulin resistance is a possible major metabolic cause of atherosclerosis." | ( Daida, H; Hoshi, S; Iwama, Y; Mokuno, H; Sawano, M; Shimada, K; Sunayama, S; Watanabe, Y; Yamaguchi, H, 2000) |
| "Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may involve fat-induced activation of a serine kinase cascade involving IKK-beta." | ( Chen, Y; Fillmore, JJ; Karin, M; Kim, JK; Kim, YJ; Lee, J; Li, ZW; Moore, I; Perret, P; Shoelson, SE; Shulman, GI; Yuan, M, 2001) |
| "Insulin resistance is present in European non-diabetic relatives of Type 2 diabetic patients." | ( Groop, L; Lehtovirta, M; Thye-Rönn, P; Vaag, A, 2001) |
| "This insulin resistance is manifested by lower rates of insulin-stimulated glucose metabolism and compensatory hyperinsulinemia in pubertal compared with prepubertal children." | ( Arslanian, SA; Danadian, K; Keenan, BS; Lewy, VD; Saad, RJ, 2001) |
| "Insulin resistance is a condition of central importance in a cluster of clinical disorders including diabetes mellitus, hypertension, dyslipidemia, central obesity and coronary heart disease." | ( Bitar, MS, 2001) |
| "Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus and a co-factor in the development of dyslipidaemia, hypertension and atherosclerosis." | ( Häring, H; Stumvoll, M, 2001) |
| "As insulin resistance is an underlying feature of premature adrenarche, it seems rational to assess the efficacy and safety of using insulin-sensitizing agents to treat these individuals." | ( Dimartino-Nardi, J; Saenger, P, 2001) |
| "GH induced insulin resistance is partially prevented by inhibition of lipolysis by Acipimox." | ( Bramnert, M; Groop, LC; Laurila, E; Manhem, P; Segerlantz, M, 2001) |
| "Insulin resistance is associated with an increased risk of atherothrombotic vascular disease, but the mechanisms are poorly understood." | ( Lassila, R; Rissanen, A; Syrjälä, M; Turpeinen, A; Vehkavaara, S; Westerbacka, J; Yki-Järvinen, H, 2002) |
| "Insulin resistance is probably the key factor in the pathogenesis of polycystic ovary syndrome, and thus insulin sensitization can be a beneficial treatment." | ( Bendlová, B; Cibula, D; Hill, M; Snajderová, M; Stárka, L; Sulcová, J; Vondra, K; Vrbíková, J, 2001) |
| "Insulin resistance is associated with hypertension, obesity, dyslipidemia, and type 2 diabetes." | ( Higashiura, K; Murakami, H; Shimamoto, K; Togashi, N; Ura, N, 2002) |
| "Insulin resistance is an important issue in the understanding of the metabolic syndrome." | ( Beck-Nielsen, H, 2002) |
| "Insulin resistance is a key pathophysiologic feature of obesity and type 2 diabetes and is associated with other human diseases, including atherosclerosis, hypertension, hyperlipidemia, and polycystic ovarian disease." | ( Jetton, TL; Qiao, LY; Sun, XJ; Zhande, R; Zhou, G, 2002) |
| "Insulin resistance is a major pathophysiological mechanism in the development of type 2 diabetes." | ( Grossman, LD, 2002) |
| "Insulin resistance is often the first abnormality detected in cases of type 2 diabetes, and is seen at the level of the peripheral tissues especially muscle." | ( Accili, D; Fernandez, AM; Kim, H; Le Roith, D, 2002) |
| "Because FFA and insulin resistance are known to predict type 2 diabetes, the finding that variation in the CAPN10 gene influences FFA levels and insulin resistance may provide an explanation for how the CAPN10 gene increases susceptibility to type 2 diabetes." | ( Groop, L; Klannemark, M; Lindgren, CM; Orho-Melander, M; Ridderstråle, M; Svensson, MK, 2002) |
| "Insulin resistance is a prominent feature of polycystic ovarian syndrome (PCOS), and women with the disorder are at increased risk for the development of other diseases that have been linked to insulin resistance-namely, type 2 diabetes and cardiovascular disease." | ( Nestler, JE, 2002) |
| "Insulin resistance is amplified by rapid childhood growth." | ( Yajnik, CS, 2002) |
| "Insulin resistance is characteristic of many patients with polycystic ovary syndrome (PCOS)." | ( Dunaif, A; Evans, JL; Goldfine, ID; Li, M; Maddux, BA; Youngren, JF; Zhang, BB, 2002) |
| "Insulin resistance is a major contributor to the pathogenesis of type 2 diabetes and plays a key role in associated metabolic abnormalities, such as dyslipidemia and hypertension." | ( Goldstein, BJ, 2002) |
| "Insulin resistance is a principal feature of type 2 diabetes and precedes the clinical development of the disease by 10 to 20 years." | ( Petersen, KF; Shulman, GI, 2002) |
| "Because insulin resistance is an underlying pathologic defect in patients with type 2 diabetes, agents that increase insulin sensitivity should be used early in the course of therapy." | ( Weissman, P, 2002) |
| "Insulin resistance is a fundamental feature of type 2 diabetes and is also associated with increased cardiovascular risk." | ( Barnett, AH, 2002) |
| "Insulin resistance is a frequently observed side effect of highly active antiretroviral therapy (HAART)." | ( Behrens, GM; Boerner, AR; Brabant, G; Ockenga, J; Schmidt, RE; van den Hoff, J; Weber, K, 2002) |
| "Obesity-related insulin resistance is closely associated with visceral fat accumulation." | ( Calcagno, A; Federspil, G; Granzotto, M; Milan, G; Pagano, C; Scarda, A; Vettor, R, 2002) |
| "Insulin resistance is a characteristic feature of type II diabetes as well as obesity." | ( Fujita, T; Ikeda, H; Kawamatsu, Y; Meguro, K; Sohda, T, 2002) |
| "Insulin resistance is assessed according to homeostasis model of assessment (HOMA-IR)." | ( Aral, Y; Cakir, B; Culha, C; Demirbaş, B; Güler, S, 2002) |
| "Insulin resistance is first aggravated after pancreas transplantation, probably due to immunosuppressive treatment including glucocorticoids, but improves on the long term." | ( Büsing, M; Klempnauer, J; Meier, JJ; Nauck, MA; Pox, C; Ritzel, R; Schmiegel, W, 2002) |
| "Insulin resistance is strongly associated with hypertension and is postulated to participate in the elevation of blood pressure, although the mechanisms involved are not understood." | ( Carroll, JA; Goodfriend, TL; Graves, W; Seely, EW; Tao, QF, 2002) |
| "Insulin resistance is involved in the pathogenesis of type 2 diabetes, hypertension, and atherosclerosis." | ( Fukuda, N; Izumi, Y; Jian, T; Kanmatsuse, K; Nakayama, M; Nakayama, T; Satoh, C; Soma, M, 2003) |
| "Insulin resistance is not directly related to renal dysfunction, but is also independently associated with hypertension in IgAN." | ( Asahi, K; Eiro, M; Katoh, T; Sakuma, Y; Sakurai, K; Suzuki, H; Watanabe, K; Watanabe, T, 2003) |
| "Insulin resistance is a characteristic feature of uremia." | ( Nesić, V; Stefanović, V; Stojimirović, B, 2003) |
| "Insulin resistance is a key component of the insulin resistance syndrome and is a crucially important metabolic abnormality in Type 2 diabetes." | ( Kearney, MT; Shah, AM; Wheatcroft, SB; Williams, IL, 2003) |
| "Insulin resistance is the most prominent feature common in both type 2 diabetes and its associated metabolic abnormalities." | ( Basu, A; Kudva, YC; Zangeneh, F, 2003) |
| "Insulin resistance is observed in individuals with normal glucose tolerance." | ( Besse, C; Giusti, V; Nicod, N; Tappy, L, 2003) |
| "Insulin resistance is a major component of metabolic syndrome, which also includes clinical abnormalities such as increased waist circumference, hypertriglyceridemia, high blood pressure." | ( Picard, S; Slama, G, 2003) |
| "Insulin resistance is a key feature of nonalcoholic fatty liver disease." | ( Bertelli, C; Dongiovanni, P; Fargion, S; Fatta, E; Fiorelli, G; Fracanzani, AL; Santorelli, G; Taioli, E; Valenti, L, 2003) |
| "Insulin resistance is associated with a number genetic syndromes and a variety of defects of insulin action." | ( Davies, HA; Patel, VK, 2003) |
| "Insulin resistance is a major hallmark in the development of type II diabetes, which is characterized by the failure of insulin to promote glucose uptake in muscle and to suppress glucose production in liver." | ( Du, K; Herzig, S; Kulkarni, RN; Montminy, M, 2003) |
| "Insulin resistance is associated with VAT products, such as free fatty acids and their metabolites, as well as cytokines, such as tumour necrosis factor alpha (TNF-alpha)." | ( Lebovitz, HE, 2003) |
| "Insulin resistance is associated with increased circulating lipids and skeletal muscle lipid content." | ( Campbell, LV; Chisholm, DJ; Ellis, BA; Gan, SK; Kelly, JJ; Kriketos, AD; O'Sullivan, A; Poynten, AM, 2003) |
| "Insulin resistance is defined as the decrease in the glucose disposal in response to insulin by the target tissues." | ( Calderón, V; Reynoso, R; Salgado, LM, 2003) |
| "The development of insulin resistance is considered to be a pivotal event in vascular risk with associated clustering of dysglycemia, hyperinsulinemia, systolic hypertension, raised triglyceride and low high-density lipoprotein cholesterol." | ( Grant, PJ, 2003) |
| "Insulin resistance is nearly universal in patients with nonalcoholic steatohepatitis (NASH) when tested by glucose tolerance tests or clamp methods." | ( Chalasani, N; Crabb, DW; Deeg, MA; Persohn, S, 2003) |
| "Insulin resistance is a key pathogenic factor of type 2 diabetes (T2DM); in contrast, in type 1 diabetes (T1DM) it is considered a secondary alteration." | ( Battezzati, A; Danna, M; De Cobelli, F; Del Maschio, A; Lattuada, G; Luzi, L; Maffi, P; Perseghin, G; Secchi, A; Sereni, LP, 2003) |
| "Insulin resistance is a risk factor for atherosclerosis and is associated with hyperinsulinemia, abnormal lipid profile, and hypertension." | ( Bryant, MB; Campia, U; Panza, JA; Quon, MJ; Sullivan, G; Waclawiw, MA, 2004) |
| "Insulin resistance is considered a risk factor in obesity, laminitis, exertional rhabdomyolysis, and osteochondrosis." | ( Boston, RC; Harris, PA; Hoffman, RM; Kronfeld, DS; Stefanovski, D, 2003) |
| "In addition, insulin resistance is also evident after EtOH exposure during lactation." | ( Chen, L; Nyomba, BL, 2004) |
| "Insulin resistance is a metabolic syndrome commonly seen in obesity." | ( Aberle, NS; Hintz, KK; Ren, J, 2003) |
| "Insulin resistance is a common feature of both polycystic ovary syndrome (PCOS) and non-insulin-dependent diabetes mellitus (NIDDM); however, the persistent reproductive disturbances appear to be limited to the former, suggesting that insulin resistance in the ovary itself may confer this susceptibility." | ( Erkkola, R; Liu, JX; Mäkinen, M; Pöllänen, P; Sallinen, K; Wu, XK; Zhou, SY, 2003) |
| "Insulin resistance is a common feature of PCOS and is more marked in obese women, suggesting that PCOS and obesity have a synergistic effect on the magnitude of the insulin disorder." | ( De Leo, V; la Marca, A; Petraglia, F, 2003) |
| "Insulin resistance is associated with visceral adiposity, and interventions that reduce this depot, e." | ( Jensen, MD; Shadid, S, 2003) |
| "Insulin resistance is a key feature in both conditions and plays an important pathophysiological role." | ( Vollenweider, P, 2003) |
| "Insulin resistance is associated with a low chronic inflammatory state." | ( Basili, S; Davì, G; Falco, A; Guagnano, MT; Manigrasso, MR; Marinopiccoli, M; Pacini, G; Romano, M; Vigneri, S, 2003) |
| "Insulin resistance is more common in overweight individuals and is associated with increased risk for type 2 diabetes mellitus and cardiovascular disease." | ( Abbasi, F; Cheal, K; Chu, J; Lamendola, C; McLaughlin, T; Reaven, G, 2003) |
| "Insulin resistance is central to the pathogenesis of type 2 diabetes and may contribute to atherogenesis, either directly or through associated risk factors." | ( Evans, M; Rees, A; Roberts, AW; Thomas, A, 2003) |
| "Insulin resistance is characterized by a decrease in the insulin effect on glucose transport in muscle and adipose tissue." | ( Barrès, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF, 2003) |
| "We conclude that insulin resistance is linked to high cholesterol synthesis and decreased cholesterol absorption." | ( Gylling, H; Laakso, M; Miettinen, TA; Pihlajamäki, J, 2004) |
| "Insulin resistance is a pivotal feature in the pathogenesis of type 2 diabetes, and it may be detected 10-20 y before the clinical onset of hyperglycemia." | ( Perseghin, G; Petersen, K; Shulman, GI, 2003) |
| "Insulin resistance is a key metabolic defect in type 2 diabetes that is exacerbated by obesity, especially if the excess adiposity is located intra-abdominally/centrally." | ( Smith, SA, 2003) |
| "Insulin resistance is an independent risk factor for arteriosclerosis and cardiovascular mortality." | ( Fischer, S; Fuecker, K; Gross, P; Hanefeld, M; Passauer, J; Pistrosch, F, 2004) |
| "Insulin resistance is a major contributor toward endothelial dysfunction in type 2 diabetes." | ( Fischer, S; Fuecker, K; Gross, P; Hanefeld, M; Passauer, J; Pistrosch, F, 2004) |
| "Increased insulin resistance is the major pathogenic mechanism in the development of non-alcoholic steatohepatitis." | ( Dagalp, K; Deveci, S; Gulsen, M; Isik, AT; Kadayifci, A; Ozgurtas, T; Tuzun, A; Uygun, A; Yesilova, Z, 2004) |
| "Since insulin resistance is associated with obesity in adults and possibly in adolescents, we set out to investigate the association of plasma leptin level with various anthropometric indices, body fat mass (FM), lipids, and insulin resistance (IR) index in nondiabetic adolescents." | ( Caterson, ID; Chen, CY; Gill, TP; Huang, KC; Kormas, N; Lee, LT; Lin, RC, 2004) |
| "Insulin resistance is defined as a HOMA index higher than 4." | ( Bueno, G; Bueno, M; Garagorri, JM; Moreno, LA; Tresaco, B, 2003) |
| "Insulin resistance is a major contributor to the pathogenesis of type II diabetes and plays a role in numerous other metabolic disorders including hypertension, dyslipidaemia and atherosclerosis." | ( Lazar, MA; Steppan, CM, 2004) |
| "Insulin resistance is a condition in which the glycemic response to insulin is less than normal." | ( Banerji, MA; Lebovitz, HE, 2004) |
| "Insulin resistance is often associated with increased triglyceride (TG) and decreased HDL-cholesterol (HDL-C) concentrations and increased small LDL particles." | ( Glazer, NB; Johns, D; Tan, MH, 2004) |
| "Insulin resistance is characterised by a decrease in insulin effect on glucose transport in muscle and adipose tIssue." | ( Barrès, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF, 2004) |
| "Insulin resistance is a metabolic spectrum that progresses from hyperinsulinemia to the metabolic syndrome, impaired glucose tolerance, and finally type 2 diabetes mellitus." | ( Bulnes-Enriquez, I; Castellani, LW; Chon, Y; De La Rosa, R; Elashoff, R; Hernandez, G; Hernandez-Pampaloni, M; Hsueh, WA; Jimenez, X; Modilevsky, T; Nicholas, SB; Quiñones, MJ; Schelbert, H; Van Herle, K; Yang, H; Yu, K, 2004) |
| "Insulin resistance is implicated in the development of these disorders." | ( Aburatani, H; Anai, M; Asano, T; Fujishiro, M; Fujita, T; Fukushima, Y; Gotoh, Y; Katagiri, H; Kikuchi, M; Komuro, I; Kushiyama, A; Noguchi, N; Ogihara, T; Ono, H; Sakoda, H; Shojima, N, 2004) |
| "Insulin resistance is a central feature of polycystic ovary syndrome (PCOS)." | ( Cheang, KI; Nestler, JE, 2004) |
| "Insulin resistance is characterized by a peripheral resistance to insulin-mediated glucose uptake, and an hepatic resistance of glucose production to insulin." | ( Ferré, P, 2004) |
| "Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress, infection, and inflammation associated with an upregulation of cytokines." | ( Kahn, CR; Kondo, T; Ueki, K, 2004) |
| "Their underlying insulin resistance is determined with the help of a checklist and a method called homeostasis model assessment (HOMA)." | ( Müller, B; Trepp, R, 2004) |
| "Obesity-related insulin resistance is associated with changes in adipose tissue release of leptin, adiponectin, and nonesterified fatty acids (NEFAs)." | ( Abate, N; Chandalia, M; Grundy, SM; Snell, PG, 2004) |
| "Insulin resistance is the common denominator in a cluster of cardiovascular disease risk factors." | ( Havel, PJ, 2004) |
| "Because insulin resistance is closely linked to increased incidence of cardiovascular diseases and given that metabolic abnormalities have been linked to initiation of heart failure, we examined the acute effects of dexamethasone (DEX) on rat cardiac metabolism." | ( Abrahani, A; Allard, M; An, D; Brownsey, R; Ghosh, S; Pospisilik, JA; Pulinilkunnil, T; Qi, D; Rodrigues, B; Wambolt, R, 2004) |
| "Insulin resistance is one of the primary characteristics of type 2 diabetes." | ( Abumrad, NA; Asghar, Z; Gavrilova, O; Haluzik, M; Héron-Milhavet, L; Hunt, D; Ibrahimi, A; Joseph, J; Jou, WC; Kim, H; LeRoith, D; Pack, S; Wheeler, MB; Yakar, S; Yau, D, 2004) |
| "Insulin resistance is present in nearly all patients with liver cirrhosis, but its etiology remains unclear." | ( Lin, SY; Sheu, WH; Wang, YY, 2004) |
| "Peripheral insulin resistance is the failure of proper cellular glucose uptake in response to insulin." | ( Fitzgerald, BP; Murphy, BA; Reedy, SE; Sessions, DR; Vick, MM, 2004) |
| "Insulin resistance is also associated with postprandial lipoprotein abnormalities in type 2 diabetes after acute correction for hyperglycemia and hyperinsulinemia." | ( Annuzzi, G; Coppola, S; De Natale, C; Del Prato, S; Di Marino, L; Iovine, C; Patti, L; Riccardi, G; Rivellese, AA, 2004) |
| "Insulin resistance is associated with cardiovascular disease, but data is lacking demonstrating that increased insulin sensitivity reduces atherosclerosis progression." | ( Bell-Farrow, AD; Cefalu, WT; Collins, J; Morgan, T; Wagner, JD; Wang, ZQ, 2004) |
| "Insulin resistance is a major endocrinopathy underlying the development of hyperglycaemia and cardiovascular disease in type 2 diabetes." | ( Bailey, CJ; Day, C, 2004) |
| "Insulin resistance is a common contributory cause to hypertriglyceridaemia." | ( Hexeberg, S; Retterstøl, K, 2004) |
| "Insulin resistance is associated with serum C-reactive protein (CRP) levels." | ( Aslan, C; Bahceci, M; Canoruc, N; Kidir, V; Tuzcu, A; Tuzun, Y, 2004) |
| "Obesity and insulin resistance are reaching epidemic proportions worldwide." | ( Duplain, H; Jayet, PY; Sartori, C; Scherrer, U; Thalmann, S; Turini, P; Vollenweider, P, 2004) |
| "Insulin resistance is the central defect in the development of type 2 diabetes, preceding its onset by 10-20 years." | ( Baumgart, D; Dagres, N; Erbel, R; Haude, M; Hüsing, J; Mann, K; Sack, S; Saller, B; Schmermund, A; von Birgelen, C, 2004) |
| "Insulin resistance is therefore associated with coronary microvasculature abnormalities in nondiabetics." | ( Baumgart, D; Dagres, N; Erbel, R; Haude, M; Hüsing, J; Mann, K; Sack, S; Saller, B; Schmermund, A; von Birgelen, C, 2004) |
| "Body mass index and insulin resistance are the two main factors governing serum leptin levels." | ( El-Bordiny, MM; El-Mohandes, AA; El-Nwaem, MA; Eldaqaq, EM; Maqlad, HM; Saleh, HA, 2004) |
| "Insulin resistance is a frequent consequence of GH replacement therapy but patients on GH replacement therapy often also have replacement of other hormone deficiencies which theoretically could modify the metabolic effects of GH." | ( Bramnert, M; Groop, LC; Laurila, E; Manhem, P; Segerlantz, M; Thomasson, R, 2004) |
| "Severe insulin resistance is a key abnormality in obese women with polycystic ovary syndrome (PCOS)." | ( Aguayo, P; Arteaga-Troncoso, G; Crespo, G; Hernández, L; Luna, S; Ortega-González, C; Parra, A, 2005) |
| "Insulin resistance is important in the occurrence of oxidative stress in patients with hypercholesterolemia." | ( Hitsumoto, T; Iizuka, T; Nakamura, K; Noike, H; Ohsawa, H; Sakurai, T; Satoh, S; Shimizu, K; Shirai, K; Sugiyama, Y; Takahashi, M; Watanabe, H, 2004) |
| "Insulin resistance is greater in SS hypertensive patients than in NSS ones." | ( Liu, J; Liu, ZQ; Ye, T; Zheng, Y; Zhu, DJ, 2005) |
| "Insulin resistance is a major intermediate link between disordered glucose metabolism and macrovascular complications." | ( Hanefeld, M, 2005) |
| "Insulin resistance is associated with low testosterone (T) levels in men, the mechanism of which is unclear." | ( Dwyer, AA; Elahi, D; Hardin, M; Hayes, FJ; Pitteloud, N; Valassi, E; Yialamas, M, 2005) |
| "Obesity and insulin resistance are common features of Type 2 Diabetes." | ( Bouchard, C; Bouchard, L; Engert, JC; Hudson, TJ; Pérusse, L; Vohl, MC; Weisnagel, SJ, 2004) |
| "Insulin resistance is a hallmark of Type II diabetes." | ( Jiang, G; Zhang, BB, 2005) |
| "Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type 2 diabetes, and yet, the mechanisms responsible for it remain poorly understood." | ( Petersen, KF; Savage, DB; Shulman, GI, 2005) |
| "Insulin resistance is associated with the elevated uric acid levels found in nonproteinuric gestational hypertensive disease." | ( Cohen, O; Homko, CJ; Schiff, E; Sivan, E; Weisz, B, 2005) |
| "Insulin resistance is found in around 80-90% of subjects with older onset (type 2) diabetes and in approximately 25% of the general population." | ( Dunn, EJ; Grant, PJ, 2005) |
| "Skeletal muscle insulin resistance is a hallmark feature of Type 2 diabetes." | ( Barnes, BR; Zierath, JR, 2005) |
| "Insulin resistance is a principal underlying defect in type 2 DM along with beta-cell dysfunction, and this insulin resistance underpins many of the abnormalities associated with the metabolic syndrome." | ( Campbell, IW, 2005) |
| "Insulin resistance is frequently accompanied by obesity and both obesity and type 2 diabetes are associated with a mild chronic inflammation." | ( Andersson, CX; Hammarstedt, A; Rotter Sopasakis, V; Smith, U, 2005) |
| "Improvement of insulin resistance is thus of great importance both in improving glucose metabolism and preventing atherosclerosis." | ( Kakuta, H; Kihara, R; Shimano, H; Suzuki, M; Tada-Iida, K; Takahashi, A; Yamada, N; Yokoo, T, 2005) |
| "Insulin resistance is a cardinal feature of Type II diabetes." | ( Desir, GV, 2005) |
| "Insulin resistance is polygenic in origin, and can be observed at an early age." | ( Humphries, SE; Jansen, H; Nicaud, V; Talmud, PJ; Waterworth, DM, 2005) |
| "Insulin resistance is frequently associated with hypertension, but the mechanism underlying this association remains speculative." | ( Endo, Y; Fujita, T; Horita, S; Kadowaki, T; Kunimi, M; Li, Y; Sakamoto, K; Seki, G; Terauchi, Y; Tobe, K; Yamada, H; Zheng, Y, 2005) |
| "To assess whether insulin resistance is associated with liver fibrosis in a group of patients with chronic hepatitis C virus (HCV) infection and whether there were any differences in insulin resistance between Asians and the indigenous Caucasian population." | ( D'Souza, R; Foster, GR; Sabin, CA, 2005) |
| "Insulin resistance is also an important predictor of sustained response to antiviral therapy." | ( D'Souza, R; Foster, GR; Sabin, CA, 2005) |
| "Insulin resistance is a factor contributing to obesity-related proteinuria." | ( Iwasawa, H; Matsumoto, H; Nagaoka, Y; Nakao, T; Okada, T; Tomaru, R; Wada, T, 2005) |
| "Insulin resistance is a risk factors for non-alcoholic fatty liver disease (NAFLD) and for gallstone disease (GD)." | ( Bertolotti, M; Carulli, L; Carulli, N; D'Amico, R; Ganazzi, D; Lombardini, S; Lonardo, A; Loria, P; Rudilosso, A; Verrone, A, 2005) |
| "Insulin resistance is the best predictor for the development of type 2 diabetes." | ( Dufour, S; Petersen, KF; Shulman, GI, 2005) |
| "Insulin resistance is a key feature of MS and plays an important role in the pathogenesis of endothelial dysfunction." | ( Cornoldi, A; Fini, M; Mercuro, G; Rosano, GM; Vitale, C; Volterrani, M, 2005) |
| "Insulin resistance is the hallmark feature of type 2 diabetes and is also an important component of the metabolic syndrome." | ( Channer, KS; Jones, TH; Kapoor, D; Malkin, CJ, 2005) |
| "Insulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease." | ( Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P, 2005) |
| "Insulin resistance is concomitant with metabolic syndrome, oxidative stress and cardiac contractile dysfunction." | ( Dong, F; Epstein, PN; Fang, CX; Ren, BH; Ren, J, 2005) |
| "Although insulin resistance is not part of the diagnostic criteria for PCOS, its importance in the pathogenesis of PCOS can not be denied." | ( Bhatia, V, 2005) |
| "Insulin resistance is one of the determinants of postprandial hyperglycemia." | ( Inoue, H; Matsui, T; Nakamura, K; Yamagishi, S, 2005) |
| "Insulin resistance is the leading force in the pathogenesis and natural history of non-alcoholic fatty liver disease." | ( Lombardini, S; Lonardo, A; Loria, P; Ricchi, M; Scaglioni, F, 2005) |
| "Clinical insulin resistance is associated with increased levels of triglycerides and other fatty acid metabolites in muscle fibers; this can give rise to diacylglycerol-mediated activation of PKC, which in turn compromises insulin signaling by triggering kinase cascades that phosphorylate IRS-1 on key serine residues." | ( McCarty, MF, 2006) |
| "Insulin resistance is defined as a state of subnormal biological response to normal quantity of insulin." | ( Urich, E, 2005) |
| "This physiological insulin resistance is not accompanied by a rise in overall sympathetic activity as reflected in plasma noradrenaline levels, but there is evidence of moderate sympathetic overactivity in muscle and the heart." | ( Kaaja, RJ; Pöyhönen-Alho, MK, 2006) |
| "Insulin resistance is considered to be one of the cornerstones in the state that ultimately leads to clinically established type 2 diabetes mellitus." | ( Chyi-Fan, S; He, CT; Hsieh, CH; Hung, YJ; Kuo, SW; Lee, CH; Lian, WC; Pei, D; Yang, TC, 2005) |
| "Insulin resistance is a central feature of type 2 diabetes." | ( Bobbert, T; Freudenberg, M; Möhlig, M; Pfeiffer, AF; Ristow, M; Rochlitz, H; Spranger, J; Weickert, MO, 2006) |
| "Although insulin resistance is associated with intimal-medial thickness of the carotid artery evaluated by B-mode ultrasonography, it is not known whether it is related to PWV." | ( Kasayama, S; Koga, M; Mukai, M; Saito, H, 2005) |
| "Insulin resistance is independently associated with PWV in non-diabetic subjects." | ( Kasayama, S; Koga, M; Mukai, M; Saito, H, 2005) |
| "Insulin resistance is an integral part of the underlying pathophysiology in most patients with nonalcoholic fatty liver disease (NAFLD)." | ( Al-Osaimi, AM; Argo, CK; Caldwell, SH, 2006) |
| "The hypothesis that insulin resistance is a result of accumulation of intracellular lipid metabolites (e." | ( Petersen, KF; Shulman, GI, 2006) |
| "In type 2 diabetes, insulin resistance is associated with vascular dysfunction/damage, impaired fibrinolysis, and low-grade inflammation independently of obesity and poor glycemic control." | ( Baldeweg, S; Ciociaro, D; Favilla, S; Ferrannini, E; Natali, A; Saccà, L; Toschi, E, 2006) |
| "Insulin resistance is promoted already in childhood by obesity and possibly by high-saturated fat intake." | ( Arffman, M; Jokinen, E; Kaitosaari, T; Kallio, K; Marniemi, J; Pahkala, K; Raitakari, O; Rönnemaa, T; Simell, O; Viikari, J, 2006) |
| "Insulin resistance is a defect in signal transduction." | ( Chakraborty, C, 2006) |
| "Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide range of other clinical and experimental settings." | ( Houstis, N; Lander, ES; Rosen, ED, 2006) |
| "Insulin resistance is a hallmark of metabolic disorders, including type 2 diabetes mellitus and obesity, which are also characterized by endothelial dysfunction." | ( Kim, JA; Koh, KK; Montagnani, M; Quon, MJ, 2006) |
| "Hepatic insulin resistance is one of the characteristics of type 2 diabetes and contributes to the development of hyperglycemia." | ( Carmella, SG; Khan, SA; Lange, AJ; Li, H; Peng, LJ; Wu, C, 2006) |
| "Insulin resistance is associated with endothelial dysfunction and increased production of the pro-inflammatory vasoconstrictor peptide endothelin-1 (ET-1)." | ( Båvenholm, P; Böhm, F; Efendic, S; Pernow, J; Shemyakin, A; Wagner, H, 2006) |
| "Insulin resistance is a risk factor for cardiovascular disease." | ( Falkner, B; Francos, G; Kushner, H, 2006) |
| "Skeletal muscle insulin resistance is mediated by fatty acid oversupply, which also contributes to the metabolic syndrome." | ( Darby, I; Febbraio, MA; Lancaster, GI; Turpin, SM; Watt, MJ, 2006) |
| "Insulin resistance is a hallmark of metabolic disorders including Type 2 diabetes, obesity, and the metabolic syndrome that are also characterized by endothelial dysfunction." | ( Quon, MJ, 2006) |
| "As insulin resistance is a key feature in type 2 diabetic patients, hyperhomocysteinemia might be a consequence of insulin resistance." | ( Balletshofer, BM; Fritsche, A; Häring, HU; Müssig, K; Schäfer, SA; Stefan, N, 2006) |
| "Insulin resistance is associated with inflammation and has a key role in atherogenesis." | ( Gil-Ortega, I; Kaski, JC; Marzoa-Rivas, R; Ríos-Vázquez, R, 2006) |
| "Insulin resistance is related to the abdominal fat and anthropometrical parameters rather than to the antiviral treatment." | ( Araújo, C; Braga, H; Cruz, M; Cruz, T; Cunha, S; Mello, V; Ney-Oliveira, F; Nuñez, G; Parana, R; Schinoni, MI; Simões, MT, 2006) |
| "Insulin resistance is related to the atherosclerotic process." | ( Harano, Y; Suzuki, M; Takamisawa, I; Yoshimasa, Y, 2007) |
| "Insulin resistance is a common problem in obese patients with type 2 diabetes." | ( Biesenbach, G; Grafinger, P; Raml, A, 2006) |
| "Hepatic insulin resistance is associated with hepatic steatosis and is thought to play an important role in the pathogenesis of steatohepatitis." | ( Horsmans, YJ; Lebrun, VA; Leclercq, IA; Stärkel, P, 2007) |
| "Insulin resistance is now considered to be major pathogenesis for diabetic macroangiopathy." | ( Daita, H; Mokuno, H; Tamura, H, 2006) |
| "Insulin resistance is associated with dyslipidemia in women with PCOS, independent of obesity." | ( Kalra, A; Nair, S; Rai, L, 2006) |
| "Insulin resistance is the major feature of the metabolic syndrome and depends on insulin secretion and insulin sensitivity." | ( Romero-Gómez, M, 2006) |
| "Insulin resistance is a common feature of obesity." | ( Attie, AD; Choi, Y; Flowers, JB; Kendziorski, CM; Nadler, ST; Oler, AT; Schueler, KL; Yandell, BS, 2007) |
| "Insulin resistance is an independent risk factor for cardiovascular disease." | ( Desouza, CV; Gerety, M; Hamel, FG, 2007) |
| "Insulin resistance is an important pathophysiological feature of the polycystic ovary syndrome (PCOS)." | ( Cheang, KI; Nestler, JE; Sharma, ST, 2006) |
| "Insulin resistance is associated with elevated plasma triacylglycerol, low HDL concentrations, elevated postprandial lipemia, and a predominance of small, dense LDLs (sdLDLs)." | ( Cooper, JA; Davies, IG; Griffin, BA; Griffin, MD; Lewis, F; Miller, GJ; Millward, DJ; Morgan, LM; Sanders, TA; Slaughter, S, 2006) |
| "Insulin resistance is a feature of a number of clinical disorders, including type 2 diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so-called metabolic syndrome." | ( Sesti, G, 2006) |
| "Because insulin resistance is among the earliest pathological changes in type 2 diabetes, our results show the potential of chemical biology for dissecting the molecular pathogenesis of this disease." | ( Bauer, I; Famulok, M; Grüne, I; Hafner, M; Kolanus, W; Kremmer, E; Paul, B; Quast, T; Schmitz, A; Srivatsan, SG, 2006) |
| "Insulin resistance is a major determinant of platelet activation in female obesity." | ( Basili, S; Ciabattoni, G; Davì, G; Guagnano, MT; Manigrasso, MR; Pacini, G; Patrono, C; Pettinella, C; Santilli, F, 2006) |
| "Insulin resistance is a major causative factor for type 2 diabetes and is associated with increased risk of cardiovascular disease." | ( Chang, K; Kaneki, M; Shimizu, N; Yamada, D, 2007) |
| "Insulin resistance is considered to play an important role in the development of cardiovascular disease, which limits long-term renal transplant survival." | ( Bakker, SJ; de Jong, PE; de Vries, AP; Gans, RO; Gansevoort, RT; Oterdoom, LH; Ploeg, RJ; van der Heide, JJ; van Son, WJ, 2007) |
| "Insulin resistance is proposed to be causally related to the metabolic syndrome disorders, but a direct cause-and-effect relationship between insulin resistance and hypertension was not originally obvious." | ( Bakris, GL; Sarafidis, PA, 2007) |
| "Insulin resistance is a key feature of type 2 diabetes." | ( Boissonnot, M; Bridoux, F; Duengler, F; Faure-Gerard, G; Guilhot, J; Hadjadj, S; Maréchaud, R; Mauco, G; Torremocha, F, 2007) |
| "Insulin resistance is associated with progression of atherosclerosis." | ( Berglund, G; Hedblad, B; Janzon, L; Nilsson, P; Zambanini, A, 2007) |
| "Obesity and insulin resistance are the predominant features in the deterioration of glucose tolerance in Thais." | ( Chailurkit, LO; Chanprasertyothin, S; Jongjaroenprasert, W; Ongphiphadhanakul, B, 2007) |
| "Although insulin resistance is recognized as a potent and prevalent risk factor for coronary heart disease, less is known as to whether insulin resistance causes an altered cardiac phenotype independent of coronary atherosclerosis." | ( Deng, JY; Huang, JP; Hung, LM; Lu, LS, 2007) |
| "Insulin resistance is associated with individual cardiometabolic factors, and plasma insulin showed association with clustering of some variables." | ( Murugesan, N; Narayan, KM; Ramachandran, A; Snehalatha, C; Yamuna, A, 2007) |
| "Obesity and insulin resistance are associated with muscle mitochondrial dysfunction, which might be related to impairment of mitochondrial protein synthesis." | ( Boirie, Y; Chanseaume, E; Giraudet, C; Gryson, C; Morio, B; Rousset, P; Walrand, S, 2007) |
| "Insulin resistance is often associated with increased adipose tissue mass." | ( Egashira, T; Ishizuka, T; Kanatsuka, A; Makino, H; Matsui, K; Onuma, H; Osawa, H; Tokuyama, Y, 2007) |
| "Muscular insulin resistance is frequently characterized by blunted increases in glucose-6-phosphate (G-6-P) reflecting impaired glucose transport/phosphorylation." | ( Brehm, A; Chmelik, M; Krssak, M; Nowotny, P; Roden, M; Schmid, AI; Szendroedi, J; Toth, C; Waldhausl, W; Wolzt, M, 2007) |
| "Insulin resistance is commonly observed in uremic patients." | ( Canbakan, M; Sahin, GM, 2007) |
| "Hepatic insulin resistance is clearly exacerbated by systemic insulin resistance and impaired handling by skeletal muscle and adipose tissue of both glucose and free fatty acids." | ( Anania, FA; Parekh, S, 2007) |
| "Insulin resistance is a hallmark characteristic of type 2 diabetes." | ( Jessen, N; Mandarino, LJ; Schmitz, O; Østergård, T, 2007) |
| "It is probable that insulin resistance is a factor that may contribute, in part, to these findings." | ( Carmina, E; Chu, MC; Lobo, R; Moran, C; Preciado, R; Tena, G; Tortoriello, D; Vardhana, P, 2008) |
| "As insulin resistance is a pathophysiologic cornerstone of diabetes and cardiovascular disease, the use of Avandamet represents an optimal approach to the treatment of diabetes." | ( Smiley, D; Umpierrez, G, 2007) |
| "Insulin resistance is characterized by pathway-specific impairment in phosphatidylinositol 3-kinase dependent signaling in both metabolic and vascular insulin target tissues." | ( Muniyappa, R; Quon, MJ, 2007) |
| "Insulin resistance is a central feature of the metabolic syndrome and progressively increases with age, resulting in excessively high incidence of type II diabetes in the elderly population." | ( Breyer, MD; Cha, DR; Fan, X; Guan, Y; Han, JY; Su, DM; Zhang, Y, 2007) |
| "Insulin resistance is associated with a spectrum of biochemical abnormalities which have the potential to reduce the availability of EPCs and diminish their capacity for vascular repair." | ( Cubbon, RM; Rajwani, A; Wheatcroft, SB, 2007) |
| "Peripheral insulin resistance is observed in most patients who have cirrhosis." | ( Bae, EJ; Kim, JW; Kim, SG; Yang, YM, 2007) |
| "Insulin resistance is considered the major mechanism involved in the hepatic and biliary manifestations of obesity." | ( Chávez-Tapia, NC; Medina-Santillán, R; Méndez-Sánchez, N; Uribe, M; Zamora-Valdés, D, 2007) |
| "Insulin resistance is well established as an independent risk factor for the development of type 2 diabetes and cardiovascular atherosclerosis." | ( Duncan, ER; Ezzat, VA; Kearney, MT; Li, JM; Shah, AM; Walker, SJ; Wheatcroft, SB, 2007) |
| "Insulin resistance is a hallmark of late pregnancy both in human and rat." | ( Bocos, C; de Castro, J; Herrera, E; Ramos, MP; Sevillano, J, 2007) |
| "Insulin resistance is accompanied by hyperinsulinemia and activation of the renin-angiotensin system, both of which are associated with hypertension." | ( Ecelbarger, CA; Halagappa, VK; Hu, X; Riazi, S; Tiwari, S, 2007) |
| "The cause of insulin resistance is not known, but may be a result of a combination of genetic and lifestyle factors." | ( Gill, V; Singal, P; Vasdev, S, 2007) |
| "Insulin resistance is a major contributor to macro- and microvascular complications, particularly in the presence of the metabolic syndrome, and is also associated with polycystic ovary syndrome." | ( Kelly, SE; Proctor, SD; Russell, JC; Vine, DF, 2007) |
| "Insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes." | ( Chen, X; Ge, X; Shi, X; Sun, C; Yan, T; Zhai, Q; Zhang, F, 2007) |
| "Insulin resistance is the failure of insulin to stimulate the transport of glucose into its target cells." | ( Lerch, R; Montessuit, C; Papageorgiou, I, 2008) |
| "Skeletal muscle insulin resistance is particularly important for its major role in insulin-mediated glucose disposal." | ( Clark, SE; Ferrario, CM; Li, W; Sowers, JR; Stump, CS; Wei, Y, 2008) |
| "Insulin resistance is a critical component of T2DM pathogenesis." | ( Ait-Goughoulte, M; Banerjee, S; Meyer, K; Ray, R; Ray, RB; Saito, K, 2008) |
| "Insulin resistance is a risk factor for cardiovascular disease." | ( Falkner, B; Kushner, H, 2008) |
| "Insulin resistance is one of the reasons of increasing carbohydrate metabolism disturbances with aging." | ( Sokup, A; Swiatkowski, M, 2007) |
| "Insulin resistance is the result of the multiple effects of the antipsychotics, among which most common are: increased body mass and direct involvement of the antipsychotics in the glucose metabolism." | ( Degmecić, D; Filaković, P; Koić, O; Laufer, D; Pozgain, I; Radanović-Grgurić, L, 2007) |
| "Insulin resistance is also involved in the pathogenesis of primary UA nephrolithiasis observed in overweight subjects with the metabolic syndrome." | ( Daudon, M; Jungers, P, 2007) |
| "Obesity and insulin resistance are highly correlated with metabolic disturbances." | ( Andreotti, S; Borges-Silva, Cd; Campana, AB; de Campos, TB; Fonseca-Alaniz, MH; Lima, FB; Machado, UF; Okamoto, M; Takada, J, 2008) |
| "Insulin resistance is the primary characteristic of type 2 diabetes which as a result of insulin signaling defects." | ( Lin, CL; Lin, JK, 2008) |
| "Insulin resistance is a major pathological condition associated with obesity and metabolic syndrome." | ( Ando, H; Ishikura, K; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Nabemoto, S; Nakanuma, Y; Ota, T; Takamura, T; Uno, M; Zen, Y, 2008) |
| "Insulin resistance is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS)." | ( Andersen, NR; Beck-Nielsen, H; Glintborg, D; Hansen, BF; Højlund, K; Wojtaszewski, JF, 2008) |
| "Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes." | ( Beck-Nielsen, H; Glintborg, D; Højlund, K; Jensen, T; Knudsen, S; Kruse, TA; Skov, V; Tan, Q, 2008) |
| "Increased insulin resistance is a therapeutic target in patients with chronic liver disease." | ( Ide, T; Kawaguchi, T; Matsuoka, H; Nagao, Y; Sata, M, 2008) |
| "Insulin resistance is a characteristic feature of type 2 diabetes and obesity." | ( Abdul-Ghani, MA; Balas, B; Chang, Z; Chavez, AO; DeFronzo, RA; Folli, F; Jani, R; Liu, Y; Molina-Carrion, M; Monroy, A; Muller, FL; Tripathy, D; Van Remmen, H; Zuo, P, 2008) |
| "Hypertension and insulin resistance are associated with reduced coronary vasodilatory capacity, possibly caused by structural changes in the coronary resistance vessels." | ( Fujimoto, Y; Hinoi, T; Kajiwara, S; Matsuo, S; Ono, T; Shichijo, T; Tomohiro, Y; Yamamoto, S, 2008) |
| "Insulin resistance is a major cause of muscle wasting in patients with ESRD." | ( Amin, A; Bevington, A; Brown, J; Clapp, E; Evans, K; Herbert, TP; Nasim, Z; Yang, B, 2008) |
| "Treatment of insulin resistance is a critical strategy in the prevention and management of type 2 diabetes." | ( Chang, CI; Cheng, HL; Chou, CH; Huang, HK; Tsai, CP, 2008) |
| "Because insulin resistance is inevitably associated with cardiovascular complications, there is a need to further investigate the potential involvement of oxidative stress and the cyclo-oxygenase (COX) pathway in the vascular modifications associated to this pathological context." | ( Alexandre, L; Behr-Roussel, D; Caisey, S; Compagnie, S; Giuliano, F; Gorny, D; Le Coz, O; Oudot, A, 2009) |
| "Insulin resistance is an important risk factor for diabetes and other diseases." | ( Bergman, RN; Hücking, K; Stefanovski, D; Watanabe, RM, 2008) |
| "Insulin resistance is a major determinant of SVR in genotype 1 CHC patients receiving peginterferon alpha-2b/ribavirin." | ( Chang, CY; Chang, FY; Chu, CJ; Hung, TH; Hwang, SJ; Lee, CY; Lee, FY; Lee, SD; Lin, HC; Lu, RH; Yang, PL; Yu, MI, 2009) |
| "Insulin resistance is considering as having a central role in NAFLD pathogenesis." | ( Lawniczak, M; Marlicz, W; Miezyńska-Kurtycz, J; Milkiewicz, P; Raszeja-Wyszomirska, J, 2008) |
| "Insulin resistance is directly related to body mass index (p < 0." | ( Catalano, D; Garufi, G; Grasso, D; Martines, GF; Sciacchitano, SG; Spadaro, D; Tonzuso, A; Trovato, GM, 2008) |
| "Insulin resistance is characterized by an impaired responsiveness to the action of insulin at its multiple target organs." | ( Brouwers, O; Schalkwijk, CG; Stehouwer, CD, 2008) |
| "Insulin resistance is associated with high levels of stored lipids in skeletal muscle cells." | ( Fisher, JS; Turcotte, LP, 2008) |
| "Insulin resistance is also common in patients with chronic hepatitis C." | ( Enjoji, M; Higuchi, N; Kato, M; Kohjima, M; Kotoh, K; Nakamuta, M; Nakashima, M, 2008) |
| "Insulin resistance is an independent risk factor for the development of cardiovascular atherosclerosis." | ( Anilkumar, N; Crossey, PA; Douglas, G; Duncan, ER; Ezzat, VA; Kearney, MI; Kearney, MT; Poston, L; Shah, AM; Walker, S; Wheatcroft, SB, 2008) |
| "Insulin resistance is a major feature of type 2 diabetes mellitus, obesity and nonalcoholic fatty liver disease (NAFLD)." | ( Gedik, O; Nar, A, 2009) |
| "Insulin resistance is an increasingly prevalent condition in humans that frequently clusters with disorders characterized by left ventricular (LV) pressure overload, such as systemic hypertension." | ( Blake, SL; Bloch, KD; Brownell, AL; Buys, ES; Derumeaux, G; Kaneki, M; Kuruppu, D; Picard, MH; Raher, MJ; Rieusset, J; Scherrer-Crosbie, M; Shimizu, N; Thibault, HB, 2008) |
| "Insulin and insulin resistance are closely related with diabetes." | ( Lü, Z; Wang, B; Wu, J; Yang, G; Zhang, H, 2008) |
| "Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while endothelial dysfunction is defined as paradoxical or inadequate endothelial-mediated vasodilation." | ( Akbay, E; Akcay, B; Camsari, A; Cicek, D; Gen, R; Genctoy, G; Gok, E; Horoz, M; Kiykim, A; Muslu, N; Ozcan, T, 2008) |
| "Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy." | ( Aurpibul, L; Lee, B; Mangklabruks, A; Puthanakit, T; Sirisanthana, T; Sirisanthana, V, 2009) |
| "Insulin resistance is prevalent in heart failure (HF) patients, and beta2 adrenergic receptors (beta2-AR) are involved in glucose homeostasis." | ( Detry, MA; Johnson, MR; Moran, JJ; Sweitzer, NK; Vardeny, O, 2008) |
| "Since insulin resistance is more frequently encountered in cats than dogs, our laboratory was interested in determining whether differences at the insulin signaling pathway level and differences in glucose and lipid metabolism could be observed between cats and dogs." | ( Arai, T; Lee, P; Mori, A; Sako, T; Takemitsu, H, 2009) |
| "Insulin resistance is implicated as the major player in the metabolic abnormalities and contributes to the increased cardiovascular risk associated with the syndrome." | ( Christakou, CD; Diamanti-Kandarakis, E, 2008) |
| "Insulin resistance is closely related to post-THW hypothyroidism in patients of DTC." | ( Chang, WD; Huang, SC; Lin, SY; Lin, YH; Sheu, WH; Song, YM; Wu, CC; Wu, VC, 2009) |
| "Skeletal muscle insulin resistance is associated with lipid accumulation, but whether insulin resistance is due to reduced or enhanced flux of long-chain fatty acids into the mitochondria is both controversial and unclear." | ( Allen, TL; Bruce, CR; Carpenter, K; Cooney, GJ; Febbraio, MA; Hoy, AJ; Kraegen, EW; Turner, N; Watt, MJ, 2009) |
| "Hepatic insulin resistance is associated with accumulation of short- and medium-, but not long-chain fatty acylcarnitines." | ( Cefalu, WT; Gettys, TW; Ribnicky, D; Soileau, JL; Stewart, LK; Wang, Z, 2009) |
| "Insulin resistance is an independent risk factor for the development of macro- and microvascular complications of Type 1 diabetes and may also contribute to the development of the disease." | ( Narendran, P; Pang, TT, 2008) |
| "Insulin resistance is a candidate predictive factor for virological response to peginterferon plus ribavirin (PEG/RBV) therapy in chronic hepatitis C patients." | ( Akiyama, T; Ario, K; Eguchi, Y; Hisatomi, A; Kawaguchi, Y; Kuwashiro, T; Mizuta, T; Otsuka, T; Oza, N; Ozaki, I; Takahashi, H; Yoshimura, T, 2010) |
| "Insulin resistance is associated with hypertension by mechanisms likely involving the kidney." | ( Ecelbarger, CM; Rash, A; Riazi, S; Sharma, N; Tiwari, S, 2009) |
| "Insulin resistance is commonly found in a large number of adults-in particular, those with android obesity, the metabolic syndrome or type 2 diabetes." | ( Capeau, J, 2008) |
| "Assessing hepatic insulin resistance is almost always synonymous with measuring hepatic glucose production (HGP) and calculating indices of hepatic insulin resistance." | ( Choukem, SP; Gautier, JF, 2008) |
| "Insulin resistance is associated with type 2 diabetes, hypertension and cardiovascular disease and the dietary factors involved in these metabolic disorders are still misunderstood." | ( Laville, M; Nazare, JA, 2009) |
| "Insulin resistance is not a relevant predictor of sustained virological response to pegylated interferon plus ribavirin in HIV/HCV co-infected patients." | ( de los Santos-Gil, I; del Valle, J; Fernández-Fuertes, E; González-Serrano, M; Macías, J; Merchante, N; Merino, D; Mira, JA; Moro, A; Pineda, JA; Ruiz-Morales, J; Sanz-Sanz, J, 2009) |
| "Insulin resistance is highly prevalent among nondiabetic CHF patients and is associated with decreased exercise capacity in patients with CHF." | ( AlZadjali, MA; Choy, A; Doney, AS; Godfrey, V; Khan, F; Lang, CC; Petrie, JR; Struthers, AD; Wong, AK, 2009) |
| "Insulin resistance is the most accepted unifying theory explaining the pathophysiology of the metabolic syndrome." | ( Mikhail, N, 2009) |
| "It was found that insulin resistance is associated with impaired capability for maintaining the homeostasis of renal uric acid excretion and reabsorption." | ( Gu, J; Li, C; Li, Y; Meng, D; Miao, Z; Wang, B; Wang, CY; Wang, J; Wang, L; Xing, X; Yan, S; Yuan, Y; Zhang, S, 2009) |
| "Insulin resistance is associated with elevated levels of tumor necrosis factor alpha (TNF-alpha), which in turn inhibits insulin receptor tyrosine kinase autophosphorylation." | ( Frost, CL; Gallant, M; Levendal, RA; Odei-Addo, F, 2009) |
| "Insulin resistance is induced by activation of the RAAS and resulting increases in ROS." | ( Gardner, M; Lastra, G; Manrique, C; Sowers, JR, 2009) |
| "Insulin resistance is a common feature of aging in both humans and rats." | ( Alonso, A; Díaz, F; González, C; Moreno, M; Ordoñez, P; Tolivia, J, 2010) |
| "Insulin resistance is a significant risk factor for the deterioration of renal function in hypertensive non-diabetic patients with CKD." | ( Endo, S; Hara, Y; Hosoya, T; Kobayashi, H; Kuriyama, S; Suetsugu, Y; Sugano, N; Tokudome, G, 2009) |
| "Skeletal muscle insulin resistance is a hallmark characteristic of type 2 diabetes, although the exact causes of insulin resistance are unknown." | ( Goodpaster, BH; Kelley, DE; Ng, JM, 2009) |
| "Insulin resistance is a characteristic feature of uremia." | ( Abdulwahab, S; Ahmed, B; Ali, M; El-Sharkawy, M; Eldin, EN; Khedr, E; Youssif, A, 2009) |
| "Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects adipose and muscle cells." | ( Coward, RJ; Lennon, R; Mathieson, PW; Pons, D; Sabin, MA; Saleem, MA; Shield, JP; Tavaré, JM; Wei, C; Welsh, GI, 2009) |
| "Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial function." | ( Bañuls, C; Gomez, M; Hernandez-Mijares, A; Rocha, M; Sanchez-Serrano, M; Sola, E; Victor, VM, 2009) |
| "Hepatic insulin resistance is a major contributor to fasting hyperglycemia in patients with metabolic syndrome and type 2 diabetes." | ( Henkel, J; Neuschäfer-Rube, F; Pathe-Neuschäfer-Rube, A; Püschel, GP, 2009) |
| "Insulin resistance is common in type 1 diabetes patients and is associated with microvascular complications." | ( Benaiges, D; Cano-Pérez, JF; Carrera, MJ; Chillarón, JJ; Flores-Le-Roux, JA; Goday, A; Pedro-Botet, J; Puig, J, 2009) |
| "Insulin resistance is the central biochemical disturbance in the metabolic syndrome." | ( Allister, EM; Edwards, JY; Hegele, RA; Huff, MW; Markle, JM; Mulvihill, EE; Sawyez, CG; Sutherland, BG; Telford, DE, 2009) |
| "In conclusion, insulin resistance is an early event in mice with cachexia induced by colon-26 tumors." | ( Asp, ML; Belury, MA; Tian, M; Wendel, AA, 2010) |
| "Insulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease." | ( Chubb, SA; Flicker, L; Hankey, GJ; Hyde, Z; Jamrozik, K; Norman, PE; Yeap, BB, 2009) |
| "Insulin resistance is frequently encountered in these patients, and correlated independently with serum HCV-RNA." | ( Bedossa, P; Boyer, N; Cardoso, AC; Marcellin, P; Martinot-Peignoux, M; Maylin, S; Moucari, R; Nicolas-Chanoine, MH; Ripault, MP; Stern, C; Valla, D; Vidaud, M; Voitot, H, 2009) |
| "Insulin resistance is associated with type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD)." | ( Isharwal, S; Misra, A; Nigam, P; Wasir, JS, 2009) |
| "Maternal insulin resistance is counteracted by the adaptation of the islets of Langerhans to the higher insulin demand." | ( Alonso-Magdalena, P; Nadal, A; Quesada, I; Ropero, AB; Soriano, S, 2009) |
| "Obesity-related insulin resistance is associated with accumulation of bioactive lipids in skeletal muscle." | ( Beck Jørgensen, S; Hewitt, K; Kemp, BE; O'Neill, HM; Steinberg, GR, 2009) |
| "Insulin resistance is a risk factor in heart failure and cardiovascular disease." | ( Connell, JM; Freel, EM; Latini, R; Lewsey, JD; Maggioni, AP; McMurray, JJ; Pitt, B; Solomon, S; Tsorlalis, IK, 2009) |
| "Insulin resistance is a common pathology in obese patients and has been shown to impair vascular function." | ( Ali, MI; Belin de Chantemele, EJ; Black, SM; Fulton, DJ; Ketsawatsomkron, P; Marrero, MB; Mintz, JD; Muta, K; Salet, C; Stepp, DW; Tremblay, ML, 2009) |
| "Insulin resistance is characterised by endothelial dysfunction, which is a pivotal step in the initiation/progression of atherosclerosis." | ( Abbas, A; Imrie, H; Kearney, M, 2010) |
| "Obesity-related insulin resistance is associated with an increase in adipocyte size." | ( de Graaf, J; Hermus, AR; Koenen, TB; Kroese, JM; Stalenhoef, AF; Stienstra, R; Sweep, FC; Tack, CJ; van der Laak, J; van Tits, LJ, 2009) |
| "Insulin resistance is partly due to suppression of insulin-induced glucose uptake into adipocytes." | ( Egawa, K; Goto, T; Hirai, S; Katoh, S; Kawada, T; Kim, YI; Kusudo, T; Lee, JY; Ohyane, C; Sakamoto, T; Taimatsu, A; Takahashi, N; Uemura, T, 2009) |
| "Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and may play a role in its pathophysiology." | ( Bertello, C; Catena, C; Dalla Pozza, A; Ermani, M; Fabris, B; Fallo, F; Mulatero, P; Sabato, N; Sechi, LA; Sonino, N; Tecchio, M; Tona, F, 2010) |
| "Insulin resistance is nearly universal in NASH and is thought to play an important role in its pathogenesis leading to dysregulated lipid metabolism." | ( Dong, MH; Loomba, R; Stein, LL, 2009) |
| "When insulin resistance is induced by exogenous lipid infusion, this interstitial diffusion process is curtailed." | ( Bergman, RN; Chiu, JD; Harrison, LN; Kirkman, EL; Kolka, CM; Lottati, M, 2010) |
| "Maternal insulin resistance is essential for efficient provision of glucose to the fetus." | ( Fujisawa, E; Hori, S; Nagira, K; Nakano, T; Saito, S; Sasaoka, T; Sugiyama, M; Tsuneki, H; Wada, T, 2010) |
| "TNF-alpha-induced insulin resistance is associated with generation of reactive oxygen species (ROS)." | ( He, Q; Huang, X; Li, J; Li, L; Man, Y; Wang, J; Wang, S; Zhou, Y, 2010) |
| "Insulin resistance is intrinsically related to intramyocellular (IMCL) rather than extramyocellular (EMCL) triglyceride content." | ( Bahia, LR; Bouskela, E; Domingues, RC; Geloneze, B; Godoy-Matos, AF; Kraemer-Aguiar, LG; Tambascia, M, 2010) |
| "Insulin resistance is common posttransplantation and contributes to both new onset diabetes after transplantation and the metabolic syndrome." | ( Baboolal, K; Dunseath, G; Luzio, S; Moore, RH; Owens, DR; Ravindran, V; Sharif, A, 2010) |
| "Insulin resistance is the main pathologic mechanism that links the constellation of clinical, metabolic and anthropometric traits with increased risk for cardiovascular disease and type II diabetes mellitus." | ( Bangit, JR; Batsell, RR; Reddy, KJ; Singh, M, 2010) |
| "Insulin resistance is the central defect in type 2 diabetes and obesity." | ( Adeli, K; Bakhtiyari, S; Larijani, B; Meshkani, R; Taghikhani, M, 2010) |
| "Type B insulin resistance is characterized by the appearance of autoantibodies to the insulin receptor." | ( Aramaki, T; Eguchi, K; Fujikawa, K; Ida, H; Iwamoto, N; Kawakami, A; Kawashiri, SY; Nakamura, H; Origuchi, T; Tamai, M, 2010) |
| "Insulin resistance is associated with dyslipidemia and MBS in women with PCOS." | ( Abou-Salem, N; El-Mazny, A; El-Sherbiny, W, 2010) |
| "Increasing insulin resistance is associated with a shift in cholesterol metabolism to increased synthesis and decreased absorption." | ( Hoenig, MR; Sellke, FW, 2010) |
| "Insulin resistance is a central feature of the PCOS and may increase cardiovascular risk." | ( Best, AM; Cheang, KI; Essah, PA; Huszar, JM; Nestler, JE; Sharma, S, 2009) |
| "Insulin resistance is a major pathogenesis underlying the development of hyperglycemia and cardiovascular diseases in type 2 diabetes." | ( Masuda, K; Terauchi, Y, 2010) |
| "Insulin resistance is commonly associated with obesity." | ( Finck, BN; Gregor, MF; Horton, JD; Hotamisligil, GS; Kars, M; Klein, S; Mittendorfer, B; Mohammed, BS; Patterson, BW; Pietka, TA; Yang, L, 2010) |
| "Insulin resistance is a risk factor for type 2 diabetes and cardiovascular disease progression." | ( Adam, KP; Beebe, K; Camastra, S; Ferrannini, E; Gall, WE; Lawton, KA; Milburn, MV; Mitchell, MW; Nakhle, PJ; Nannipieri, M; Natali, A; Ryals, JA, 2010) |
| "Insulin resistance is a common symptom of metabolic diseases such as obesity, type 2 diabetes and hyperlipidemia." | ( Kang, S; Kim, DS; Park, S, 2011) |
| "Insulin resistance is a characteristic of type 2 diabetes and is a major independent risk factor for progression to the disease." | ( Brady, JD; Crowther, D; Feuerstein, GZ; Grierson, CE; Hansen, MK; Hundal, HS; Logie, L; Morris, AD; Pearson, E; Ruiz-Alcaraz, AJ; Schofield, CJ; Shepherd, B; Sutherland, C; Tommasi, AM, 2010) |
| "Insulin resistance is associated with the pathogenesis of metabolic disorders as type 2 diabetes and obesity." | ( Díez, J; Fernández-Veledo, S; Garcia-Guerra, L; Jurado-Pueyo, M; Lorenzo, M; Mayor, F; Murga, C; Nieto-Vazquez, I; Vila-Bedmar, R; Zalba, G, 2010) |
| "Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure." | ( Bhandari, S; Semple, D; Seymour, AM; Smith, K, 2011) |
| "Insulin resistance is associated with an inappropriate elevation of plasma free fatty acids (FFAs) and endothelial dysfunction." | ( Bao, Y; Li, H; Yu, Y; Zhang, X, 2011) |
| "In addition, insulin resistance is not limited to classic insulin-sensitive tissues such as skeletal muscle, but it also affects the cardiovascular system, where it participates in the development of CVD and CKD." | ( Dhuper, S; Johnson, MS; Lastra, G; Sowers, JR, 2010) |
| "Also, insulin resistance is generally considered to be of major importance in the pathophysiology of type 2 diabetes mellitus." | ( Nasr, G; Sliem, H, 2011) |
| "This vascular insulin resistance is likely to contribute to the endothelial dysfunction and erectile dysfunction associated with insulin resistant states." | ( Benedito, S; Climent, B; Contreras, C; García-Sacristán, A; Martínez, P; Prieto, D; Raposo, R; Sánchez, A, 2010) |
| "Insulin resistance is also associated with hypertriglyceridaemia." | ( Akin, KO; Ertugrul, DT; Karadag, AS; Tutal, E, 2011) |
| "Insulin resistance is a major pathophysiological factor in the development of type 2 diabetes, occurring mainly in muscle, adipose tissues, and liver leading to reduced glucose uptake and utilization and increased glucose production." | ( Aggarwal, S; Bhardwaj, TR; Kumar, M; Thareja, S, 2012) |
| "Insulin resistance is a causal factor in prediabetes (PD) and type 2 diabetes (T2D) and increases the risk of developing Alzheimer disease (AD)." | ( Baker, LD; Belongia, D; Craft, S; Cross, DJ; Minoshima, S; Watson, GS, 2011) |
| "Obesity and insulin resistance are risk factors for laminitis in horses and ponies, and diet can play an important role in modulating these risk factors." | ( Geor, RJ; Myers, K; Respondek, F; Smith, TL; Wagner, A, 2011) |
| "Insulin resistance is associated with chronic low-grade inflammation in vivo, largely mediated by activated innate immune cells." | ( Bilan, PJ; Chiu, TT; Foley, KP; Klip, A; Philpott, DJ; Schertzer, JD; Tamrakar, AK, 2010) |
| "This insulin resistance is not due to decreased canonical insulin signaling, accumulation of lipid intermediates, inflammation, or direct inhibition of GLUT activity." | ( Birk, JB; Bisiani, B; Frøsig, C; Hiscock, N; Høeg, LD; Jensen, TE; Jeppesen, J; Kiens, B; Pilegaard, H; Richter, EA; Sjøberg, KA; Wojtaszewski, JF, 2011) |
| "Lipid-induced insulin resistance is associated with inflammatory state in epidemiological studies." | ( Ding, H; Guo, Y; Li, D; Wu, W; Zhang, J, 2010) |
| "Insulin resistance is a prominent feature of polycystic ovary syndrome (PCOS), and insulin-sensitizing drugs are used to induce ovulation." | ( Anzai, H; Chen, JT; Matsuoka, R; Sato, Y; Tominaga, K, 2010) |
| "Insulin resistance is the most important pathophysiological feature in many pre-diabetic states." | ( Benito, M, 2011) |
| "Insulin resistance is associated with PAD and may contribute to claudication by impairing skeletal muscle metabolism." | ( Copeland-Halperin, RS; Creager, MA; Desai, AS; Di Carli, MF; Doyle, J; Navarrete, N; Pande, RL; Park, MA; Perlstein, TS; Redline, W, 2011) |
| "Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and atherosclerosis." | ( Bunn, RC; Cockrell, GE; Fowlkes, JL; Lumpkin, CK; Ou, Y; Thrailkill, KM, 2010) |
| "Insulin resistance is a risk factor for various age-related diseases." | ( le Cessie, S; Mooijaart, SP; Pijl, H; Rozing, MP; Slagboom, PE; Streefland, TC; van Heemst, D; Westendorp, RG; Wijsman, CA, 2011) |
| "Insulin resistance is manifested in muscle, adipose tissue, and liver and is associated with adipose tissue inflammation." | ( Chapman, J; Johnson, K; Miles, PD; Neels, JG; Ofrecio, JM; Resnik, JL; Sears, DD; Talukdar, S; Thapar, D; Wilkes, J; Yu, JG, 2010) |
| "Insulin resistance is frequent in Afro-Caribbean women with HIV infection." | ( Bastard, JP; Batard, ML; Capeau, J; Chene, G; Cheret, A; Deloumeaux, J; Foucan, L; Lamaury, I; Maachi, M; Muller, P; Sow-Goerger, MT; Velayoudom, FL, 2011) |
| "Insulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes." | ( Berkeley, JE; Chase, JG; Docherty, PD; Hann, CE; Lotz, TF; Mann, JI; McAuley, KA; Shaw, GM; Williams, SM, 2010) |
| "Insulin resistance is an independent predictor of cardiovascular mortality in hemodialysis (HD) patients." | ( Abe, M; Matsumoto, K; Okada, K; Soma, M, 2011) |
| "Insulin resistance is associated with EPO responsiveness in HD patients." | ( Abe, M; Matsumoto, K; Okada, K; Soma, M, 2011) |
| "Insulin resistance is closely associated with numerous metabolic disorders." | ( Antonopoulos, CN; Aronis, K; Dessypris, N; Efremidis, A; Mantzoros, CS; Matsoukis, IL; Petridou, ET; Sergentanis, TN; Syrigos, C, 2011) |
| "Hyperglycemia with insulin resistance is commonly seen in severely burned patients and tight glycemia control with insulin may be beneficial in this condition." | ( Carter, EE; Chai, JK; Fagan, S; Fischman, AJ; Lu, XM; Shen, CA; Tompkins, RG; Yu, YM, 2011) |
| "Insulin resistance is the primary cause responsible for type 2 diabetes." | ( Jung, JH; Kim, HS; Kim, JH; Kim, SJ; Lee, JO; Lee, SK; Moon, JW; Park, JM; Park, SH; Suh, PG; Uhm, KO; You, GY, 2011) |
| "Obesity and insulin resistance are risk factors for laminitis in equids and supplements containing chromium and magnesium might improve insulin sensitivity." | ( Boston, RC; Chameroy, KA; Elliott, SB; Frank, N, 2011) |
| "Insulin resistance is associated with elevated content of skeletal muscle lipids, including triacylglycerols (TAGs) and diacylglycerols (DAGs)." | ( Badin, PM; Langin, D; Liebisch, G; Louche, K; Mairal, A; Moro, C; Rustan, AC; Schmitz, G; Smith, SR, 2011) |
| "Insulin resistance is the most important pathophysiological feature in many pre-diabetic states." | ( Benito, M, 2011) |
| "Because insulin resistance is observed in patients with polycystic ovary syndrome, we hypothesized that TAC or SIR may induce reproductive abnormalities." | ( Clure, CE; Davis, JS; Hamel, FG; Larsen, J; Maroni, D; Ochsner, L; Passer, J; Shivaswamy, V; Wang, C, 2011) |
| "Hepatic insulin resistance is a major contributor to hyperglycemia in metabolic syndrome and type II diabetes." | ( Dorn, C; Elz, SR; Gärtner, D; Hellerbrand, C; Henkel, J; Püschel, GP; Schanze, N, 2011) |
| "Insulin resistance is getting important in the course of type 1 diabetes mellitus." | ( Akalın, S; Aydın, H; Deyneli, O; Özben, B; Tarcin, Ö; Yavuz, D; Yazıcı, D, 2011) |
| "GH-induced insulin resistance is rapidly reversible." | ( Christiansen, JS; Clasen, BF; Jessen, N; Jørgensen, JO; Krusenstjerna-Hafstrøm, T; Møller, N; Pedersen, SB, 2011) |
| "Insulin resistance is a major characteristic of obesity and type 2 diabetes, and develops in multiple organs, including the heart." | ( Gray, S; Kim, JK, 2011) |
| "Insulin resistance is frequently present in obesity and during the development of type 2 diabetes mellitus." | ( Ishizaki, N; Kitakoji, H; Naruse, Y; Tominaga, A; Yamamura, Y, 2011) |
| "Insulin resistance is often found to be associated with high blood pressure." | ( Kumar, U; Macleod, KM; McClure, B; McNeill, JH; Nagareddy, PR; Rajput, PS; Vasudevan, H, 2012) |
| "Hepatic insulin resistance is characteristic of T3cDM and is caused by deficiencies of both insulin and pancreatic polypeptide." | ( Andersen, DK; Cui, Y, 2011) |
| "Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function." | ( Alvarez, A; Bañuls, C; de Pablo, C; Gomez, M; Hernandez-Mijares, A; Rocha, M; Sanchez-Serrano, M; Victor, VM, 2011) |
| "Insulin resistance is not the cause of metabolic syndrome, it is a passive byproduct of fat deposition in the liver and muscle." | ( Fodor, M, 2011) |
| "Insulin resistance is usually asymptomatic but is associated with health problems and is a factor in the metabolic syndrome." | ( Cheng, C; Goto, A; Inoue, T; Kadowaki, T; Minamimoto, R; Nakamura, A; Shinoda, K; Tateishi, U; Terauchi, Y, 2011) |
| "A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing countries." | ( Aerts, JM; Aten, J; Bietrix, FM; Bijl, N; Boot, RG; Dekker, N; Groen, AK; Groener, J; Langeveld, M; Lombardo, E; Ottenhoff, R; Overkleeft, HS; Serlie, M; van Eijk, M; van Roomen, C; Wennekes, T, 2011) |
| "Insulin resistance is common finding in patients with HIV/HCV coinfection, with wide clinical consequences including progression of hepatic fibrosis and reduction in the response to antiviral treatment." | ( Eslam, M; López-Cortés, LF; Romero-Gomez, M, 2011) |
| "Insulin resistance is linked to polycystic ovary syndrome." | ( Legro, RS; Pauli, JM; Raja-Khan, N; Wu, X, 2011) |
| "Obesity and insulin resistance are the two most common risk factors for NASH, which can lead to recurrent NASH after liver transplantation." | ( Mukherjee, S, 2011) |
| "Insulin resistance is associated with inflammation, fibrosis, and hypoxia in adipose tissue." | ( Kern, PA; McGehee, RE; Peterson, CA; Rasouli, N; Spencer, M; Unal, R; Zhu, B, 2011) |
| "Insulin resistance is one of the leading factors for severe fibrosis in chronic HCV infections." | ( Basaranoglu, G; Basaranoglu, M, 2011) |
| "Obesity and insulin resistance are associated with chronic, low grade inflammation." | ( Aatsinki, SM; Buler, M; Georgiadi, A; Hakkola, J; Kerkelä, R; Kersten, S; Komka, Z; Skoumal, R; Tóth, M, 2012) |
| "Insulin resistance is a clinical condition that is characterized by reducing glucose uptake in response to insulin." | ( Chen, D; Chen, X; Huang, Z; Jia, G; Mao, X; Wu, X, 2012) |
| "Insulin resistance is characterised by impaired glucose utilisation when measured by a euglycaemic-hyperinsulinaemic clamp." | ( Galgani, JE; Ravussin, E, 2012) |
| "Burn-induced insulin resistance is associated with persistent ER/sarcoplasmic reticulum stress/UPR and subsequent suppressed insulin receptor signaling over a prolonged period of time." | ( Baker, HV; Boehning, D; Finnerty, CC; Gauglitz, GG; Herndon, DN; Jeschke, MG; Song, J; Tompkins, RG, 2012) |
| "Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF)." | ( Aimaretti, G; Cittadini, A; Isgaard, J; Longobardi, S; Monti, MG; Napoli, R; Netti, PA; Rea, D; Saccà, L; Samà, M; Walser, M, 2012) |
| "Insulin resistance is a complication of advanced CKD." | ( Biggs, ML; de Boer, IH; Fried, LF; Ix, JH; Kestenbaum, B; Mukamal, KJ; Pham, H; Robinson-Cohen, C; Siscovick, DS, 2012) |
| "Insulin resistance is a predictor of poor response to peginterferon/ribavirin in patients infected with the chronic hepatitis C virus (HCV)." | ( Beumont, M; Carosi, G; DeMasi, R; Drenth, JP; Ferenci, P; Forns, X; Goeser, T; Lonjon-Domanec, I; Marcellin, P; Nevens, F; Picchio, G; Serfaty, L, 2012) |
| "Insulin resistance is a key pathological feature of type 2 diabetes and is characterized by defects in signaling by the insulin receptor (IR) protein tyrosine kinase." | ( Tiganis, T, 2013) |
| "Insulin resistance is a key factor in the etiology of type 2 diabetes." | ( Akassoglou, K; Baeza-Raja, B; Bridges, D; Davalos, D; Kim, C; Le Moan, N; Li, P; Olefsky, JM; Sachs, BD; Saltiel, AR; Schachtrup, C; Vagena, E, 2012) |
| "Insulin resistance is one of the most common features of polycystic ovary syndrome (PCOS)." | ( Ardabili, HR; Farzadi, L; Gargari, BP, 2012) |
| "Insulin resistance is a hallmark of obesity and type 2 diabetes." | ( Davies, SM; Li, J; Maynard, S; Mehta, PA; Pang, Q; Rose, SR; Sipple, J, 2012) |
| "Insulin resistance is a risk factor for non-response to interferon/ribavirin therapy in patients with chronic hepatitis C." | ( García-Ruiz, I; Gómez-Izquierdo, E; Muñoz-Yagüe, MT; Solís-Herruzo, JA; Solís-Muñoz, P; Valverde, AM, 2012) |
| "Hyperglycemia and insulin resistance are common findings in critical illness." | ( Franklin, JL; Hardy, RW; Martin, RE; Messina, JL; Williams, VL, 2012) |
| "Diabetes type 2 and insulin resistance are the risk factors for cardiovascular disease." | ( Vasic, D; Walcher, D, 2012) |
| "Insulin resistance is recognized as a common metabolic factor which predicts the future development of both type 2 diabetes and atherosclerotic disease." | ( Chen, SJ; Fu, XD; Liu, SP; Mu, PW; Tan, Z; Wang, TH; Zhou, LJ, 2012) |
| "Insulin resistance is a prominent feature in heart failure, while hyperglycemia impairs cardiac contraction." | ( Guthrie, PH; Harmancey, R; Lam, TN; Lubrano, GM; Taegtmeyer, H; Vela, D, 2012) |
| "Insulin resistance is more common in carriers of the T allele of SNP rs12979860 than in CC homozygotes and may partly explain the poor outcome of peginterferon/ribavirin therapy in these patients." | ( Beinhardt, S; Datz, C; Ferenci, P; Hofer, H; Krebs, M; Rutter, K; Scherzer, TM; Stadlmayr, A; Stättermayer, AF; Steindl-Munda, P; Trauner, M; Wrba, F, 2012) |
| "We tested whether insulin resistance is present in cachectic lung cancer patients and if a sustained, physiological elevation of amino acids with hyperinsulinemia would compensate for it." | ( Chevalier, S; MacAdams, J; Winter, A, 2012) |
| "Insulin resistance is perceived as deleterious, associated with conditions as the metabolic syndrome, type 2 diabetes mellitus and critical illness." | ( Soeters, MR; Soeters, PB, 2012) |
| "Since insulin resistance is the major etiology for type 2 DM and numerous evidences showed that HCV infection associated with insulin resistance, the involvement of E2 in the pathogenesis of type 2 DM and underlying mechanisms were investigated in this study." | ( Chen, TY; Chiou, HL; Hsieh, MJ; Lan, KP; Lin, YF; Liu, HY; Zhang, XZ, 2012) |
| "Obesity and insulin resistance are associated with low-grade chronic inflammation." | ( Choi, CS; Choung, JS; Ha, SY; Jun, HS; Kang, Y; Kim, SS; Kim, Y; Lee, YS; Oh, HH; Park, MS, 2012) |
| "Insulin resistance is associated with a variety of cardiometabolic problems leading to increased morbidity and mortality across the lifespan." | ( Cree-Green, M; Mizokami-Stout, K; Nadeau, KJ, 2012) |
| "Type 2 diabetes and insulin resistance are often associated with the co-occurrence of coronary atherosclerosis and cardiac dysfunction." | ( Chubuchny, V; Di Cecco, P; Emdin, M; Ferrannini, E; Guiducci, L; Iozzo, P; Knuuti, J; Lautamäki, R; Masi, S; Morales, MA; Neglia, D; Nuutila, P; Pardini, S; Porciello, C; Salvadori, PA; Sironi, AM, 2012) |
| "Insulin resistance is accompanied by increased activity of carbonic anhydrase which is significantly related to increasing methylglyoxal levels." | ( Biswas, UK; Kumar, A, 2012) |
| "Cardiac insulin resistance is characterized by reduced availability of sarcolemmal Glut-4 transporters and consequent lower glucose uptake." | ( Bell, JR; Delbridge, LM; Mellor, KM; Ritchie, RH, 2013) |
| "Insulin resistance is a pathological condition that arises when insulin signaling is impaired, forcing β-cells to produce more insulin in order to cope with body demands and to maintain glucose homeostasis." | ( Andrès, E; Dali-Youcef, N; Mecili, M; Ricci, R, 2013) |
| "Insulin resistance is closely related to the presence of CAD in newly diagnosed patients with different glucose metabolic status." | ( Feng, B; Hu, B; Liu, F; Lu, W; Wang, H, 2012) |
| "Insulin resistance is present as an early feature of Bmpr2 mutation in mice." | ( Fessel, JP; Gleaves, L; Hemnes, AR; Johnson, JA; Niswender, KD; Pugh, ME; West, J, 2013) |
| "Insulin resistance is associated with the progression of atherosclerosis and is reported to predict cardiovascular mortality in patients with end-stage renal disease (ESRD)." | ( Chang, TI; Doh, FM; Han, DS; Han, SH; Kang, SW; Kim, CH; Ko, KI; Koo, HM; Lee, MJ; Oh, HJ; Shin, DH; Yoo, TH, 2012) |
| "Insulin resistance is present in obesity and in type 2 diabetes and is associated with islet cell hyperplasia and hyperinsulinemia, but the driving forces behind this compensatory mechanism are incompletely understood." | ( Araújo, TG; Boschero, AC; Carvalheira, JB; Carvalho, BM; Guadagnini, D; Oliveira, AG; Protzek, AO; Saad, MJ, 2012) |
| "Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance insulin sensitivity." | ( Bogdański, P; Krejpcio, Z; Król, E; Michalak, S; Wójciak, RW, 2012) |
| "Obesity-related insulin resistance is linked to a chronic state of systemic and adipose tissue-derived inflammation." | ( Christ-Crain, M; Dembinski, K; Frey, DM; Grisouard, J; Herzog-Radimerski, T; Keller, U; Müller, B; Peterli, R; Sauter, NS; Timper, K; Zulewski, H, 2013) |
| "Insulin resistance is associated with the pathogenesis of metabolic disorders such as type 2 diabetes and obesity; however, the potential role of GRK5 in insulin resistance is unknown." | ( Ma, L; Shen, M; Wang, F; Wang, L, 2012) |
| "Adipose tissue insulin resistance is a significant feature of type 1 diabetes." | ( Bergman, BC; Clement, TW; Eckel, RH; Howard, D; Maahs, DM; Perreault, L; Rewers, M; Schauer, IE; Snell-Bergeon, JK, 2013) |
| "Insulin resistance is a characteristic feature of glucose intolerance in myotonic dystrophy type 1 (DM1)." | ( Goto, T; Kon, S; Oyama, Y; Takada, H, 2012) |
| "Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly linked to intra-abdominal fat than to fat in other depots." | ( Kataria, MA; Saini, V; Yadav, A, 2013) |
| "Insulin resistance is associated with visceral adiposity described by VAI and WC." | ( Banach, M; Paradowski, M; Rizzo, M; Rysz, J; Stepien, A; Stepien, M; Wlazel, RN, 2014) |
| "Insulin resistance is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular diseases." | ( Muniyappa, R; Sowers, JR, 2013) |
| "Insulin resistance is a very common associate of polycystic ovary syndrome (PCOS)." | ( Chakraborty, P; Chakravarty, B; Ghosh, S; Goswami, SK; Jana, K; Kabir, SN, 2013) |
| "Insulin resistance is characterized by excessive endothelial cell generation of potentially cytotoxic concentrations of reactive oxygen species." | ( Beech, DJ; Channon, KM; Cubbon, RM; Gage, M; Galloway, S; Gatenby, VK; Imrie, H; Kandavelu, P; Kearney, MT; Santos, CX; Shah, AM; Skromna, A; Smith, J; Sukumar, P; Viswambharan, H; Wheatcroft, SB; Yuldasheva, N, 2013) |
| "Insulin resistance is a key condition in the development of type 2 diabetes." | ( Arévalo, MI; Barberà, A; Caelles, C; Gomis, R; Lanuza-Masdeu, J; Vila, C, 2013) |
| "The presence of insulin resistance is increasingly recognized as an important contributor to early stage kidney disease independent of the contribution of diabetes." | ( Nistala, R; Whaley-Connell, A, 2013) |
| "Insulin resistance is associated with the impairment of the response of insulin receptor to insulin, resulting in the reduction of glucose uptake, leading to the alteration of myocardial glucose metabolism, impairment of cardiac electrophysiology, and increased susceptibility to ischemia-induced myocardial injury." | ( Chattipakorn, N; Chattipakorn, S; Kumphune, S, 2013) |
| "Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells." | ( Baron, AD; Mather, KJ; Steinberg, HO, 2013) |
| "Metabolic insulin resistance is apparent across a spectrum of clinical disorders, including obesity and diabetes, and is characterized by an adverse clustering of cardiovascular risk factors related to abnormal cellular responses to insulin." | ( Cubbon, RM; Kearney, MT; Mercer, BN; Sengupta, A, 2013) |
| "Insulin resistance is associated with cardiac sympathovagal imbalance, cardiac dysfunction and cardiac mitochondrial dysfunction." | ( Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H, 2013) |
| "The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic relationship remains controversial." | ( Bonomi, LM; Brown, ML; Schneyer, AL; Ungerleider, NA, 2013) |
| "Insulin resistance is strongly associated with the development of type 2 diabetes and cardiovascular disease." | ( Adeli, K; Ji, J; Jiang, B; Liu, L; Lu, J; Meng, H; Meng, QH; Randell, E; Wang, D, 2013) |
| "Hyperglycemia and insulin resistance are key players in the development of atherosclerosis and its complications." | ( Beckman, JA; Cosentino, F; Creager, MA; Paneni, F, 2013) |
| "Insulin resistance is one of the feature of obesity." | ( Dincer, Y; Himmetoglu, S; Taskın, M; Teksoz, S; Yesim, T; Zengin, K, 2013) |
| "Insulin resistance is the hallmark of type 2 diabetes mellitus (T2DM), which is closely related to disorder of lipid metabolism." | ( Hai, C; Li, W; Liao, N; Liu, R; Qin, X; Wang, X; Wang, Z; Zhang, W; Zhang, X, 2013) |
| "PCOS and insulin resistance are interlinked, as approximately 40 % of women with PCOS are insulin resistant." | ( Godla, UR; Lakkakula, BV; Thangavelu, M, 2013) |
| "Obesity and insulin resistance are the key factors underlying the etiology of major health problems such as hypertension, diabetes and stroke." | ( Brum, LM; de Assis, AM; Hansen, F; Moreira, JD; Perry, ML; Riboldi, BP; Souza, CG; Souza, DG; Souza, DO, 2013) |
| "Although insulin resistance is usually associated with the development of type 2 diabetes, it can also be a feature of patients with type 1 diabetes." | ( Bulum, T; Duvnjak, L, 2013) |
| "Insulin resistance is significantly associated with the long-term risks of metabolic syndrome and cardiovascular disease." | ( Hou, L; Kuang, H; Li, Y; Ma, H; Ng, EH; Wu, X; Zhang, Y, 2013) |
| "Insulin resistance is the core perturbation of metabolic syndrome." | ( Simopoulos, AP, 2013) |
| "Insulin resistance is defined as a reduced ability of insulin to stimulate glucose utilization." | ( Bucarey, JL; Campos, C; Contreras-Ferrat, A; Díaz-Vegas, A; Espinosa, A; Galgani, JE; Jaimovich, E; Juretic, N; Llanos, P; Osorio-Fuentealba, C; Tapia, G; Valenzuela, R, 2013) |
| "Insulin resistance is an independent pathogenic mechanism in liver function test changes regardless of metabolic syndrome in nondiabetic centrally obese youth." | ( Culafic, D; Dimitrijevic-Sreckovic, V; Djordjevic, P; Ille, T; Popovic, S; Soldatovic, I; Sreckovic, B, 2013) |
| "Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development." | ( Cubbon, RM; Gage, MC; Galloway, S; Imrie, H; Jackson, CL; Kearney, MT; Skromna, A; Smith, J; Sukumar, P; Viswambharan, H; Wheatcroft, SB; Yuldasheva, NY, 2013) |
| "Muscular insulin resistance is a characteristic of obesity and type 2 diabetes, but little is known about fatty acid (FA) metabolism in insulin-resistant skeletal muscle." | ( Matsuo, T; Ochiai, M, 2013) |
| "Although insulin resistance is detected in the majority of post-transplant patients, NODAT also reveals also an insulin secretory defect." | ( Narayan, G; Sahay, M; Sahay, RK, 2013) |
| "Insulin resistance is the hallmark of type 2 diabetes." | ( Chen, H; Hai, C; Liao, N; Wang, X; Wang, Z; Zhang, W; Zhang, X, 2014) |
| "The hallmark of insulin resistance is a gradual break-down of insulin-regulative glucose uptake by muscle and adipose tissues in subjects." | ( Bo, P; Fang, P; Guo, L; Shi, M; Yu, M; Zhang, Z, 2014) |
| "Insulin resistance is a characteristic feature of Type 2 diabetes." | ( Anthony, J; Bhumra, SK; Deka, N; Kelkar, A; Marita, AR; Mutt, S; Mutt, SJ; Ranjith, V; Sharma, S; Sivaramakrishnan, H; Wilankar, C, 2013) |
| "Insulin resistance is the primary characteristic of type 2 diabetes." | ( Cordero-Herrera, I; Goya, L; Martín, MÁ; Ramos, S, 2014) |
| "Insulin resistance is a complex altered metabolic condition characterized by impaired insulin signaling and implicated in the pathogenesis of serious human diseases, such as diabetes, obesity, neurodegenerative pathologies." | ( Amuso, S; Camici, G; Caselli, A; Maccari, R; Mortier, J; Ottanà, R; Paoli, P; Rotondo, A; Wolber, G, 2014) |
| "Insulin resistance is present at the muscle mitochondrial level, and is not affected by reducing circulating NEFAs in type 2 diabetes." | ( Jelenik, T; Nowotny, P; Phielix, E; Roden, M; Szendroedi, J, 2014) |
| "If insulin resistance is present, β cells maintain normal glucose tolerance by increasing insulin output." | ( Cooper, ME; Del Prato, S; Kahn, SE, 2014) |
| "Insulin resistance is a link between obesity and the associated disease risk." | ( Adam, TC; Goran, MI; Hasson, RE; Hu, H; Page, KA; Tsao, S, 2015) |
| "Insulin resistance is a core component of metabolic syndrome and usually precedes the development of type 2 diabetes mellitus." | ( Duke, CC; Kota, BP; Li, Y; Nammi, S; Roufogalis, BD; Tran, VH, 2014) |
| "Insulin resistance is a fundamental feature of metabolic disorders such as metabolic syndrome." | ( Ebata, Y; Hama, S; Ikeda, Y; Kogure, K; Sakabe, T; Shiota, G; Takeuchi, M; Takino, J; Tsuchiya, H, 2013) |
| ": Insulin resistance is associated with nonresponse to hepatitis C virus (HCV) treatment." | ( Alston-Smith, B; Andersen, J; Chung, RT; Glesby, MJ; Hadigan, C; Kitch, D; Luetkemeyer, A; Marks, KM; Tien, P, 2014) |
| "Insulin resistance is featured by low circulating bilirubin." | ( Bakker, SJ; Deetman, PE; Dullaart, RP; Kwakernaak, AJ; Navis, G, 2014) |
| "Insulin resistance is a key feature of both NAFLD and GD." | ( Ahmed, MH; Ali, A, 2014) |
| "Insulin resistance is a major feature and pathogenic factor of nonalcoholic fatty liver disease (NAFLD)." | ( Li, XY; Liu, XM; Wang, XC; Yu, JJ; Zhan, XR, 2015) |
| "Central insulin resistance is amendable to therapeutic intervention, reflected in the central effects of topiramate and glucagon-like peptide-1 on hepatic and peripheral insulin resistance in insulin resistant mice." | ( Coomans, CP; Parlevliet, ET; Rensen, PC; Romijn, JA, 2014) |
| "Insulin resistance is a complex metabolic disorder that defies explanation by a single etiological pathway." | ( Annabi, A; Dhouib, IB; El Fazaa, S; Gharbi, N; Lasram, MM, 2014) |
| "Obesity and insulin resistance are associated with increased oxidant stress." | ( Corkey, BE; Guo, W; Hamilton, JA; Kirkland, JL; Schwanz, HA; Simmons, AL; Wong, S, 2014) |
| "Insulin resistance is difficult to establish in clinical practice and many surrogate tests are available, although their value in the clinical setting is uncertain." | ( Bhagavath, B; Hoeger, K; Queenan, J; Vitek, W, 2014) |
| "Insulin resistance is associated with increased cardiovascular diseases." | ( Alnahal, AA; Fathy, A; Fathy, T; Tahan, M, 2014) |
| "Insulin resistance is a complex metabolic disorder in which insulin-sensitive tissues fail to respond to the physiological action of insulin." | ( Fayyaz, S; Japtok, L; Kleuser, B, 2014) |
| "Insulin resistance is a recently investigated risk factor, and the risk of goitre may be reversible with metformin treatment." | ( Brix, TH; Knudsen, N, 2014) |
| "Insulin resistance is a clinical condition shared by many diseases besides type 2 diabetes (T2DM) such as obesity, polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD)." | ( Barbaro, V; Dicembrini, I; Pala, L; Rotella, CM, 2014) |
| "Insulin resistance is commonly observed in uremic patients." | ( Choovichian, P; Leelasiri, K; Satirapoj, B; Supasyndh, O, 2014) |
| "Insulin resistance is related to the excessive O-GlcNAcylation of key metabolic proteins causing a chronic blunting of insulin signalling pathways and precipitating the accompanying pathologies, such as heart and kidney disease." | ( Belke, DD; Myslicki, JP; Shearer, J, 2014) |
| "Insulin resistance is associated with inadequate body composition, in biochemical levels and lifestyle, being the factors associated different in each phase of adolescence." | ( Faria, ER; Faria, FR; Franceschini, Sdo C; Novaes, JF; Peluzio, Mdo C; Priore, SE; Ribeiro, AQ; Ribeiro, SM; Sant Ana, LF, 2014) |
| "HS-induced insulin resistance is driven by impaired microvascular responsiveness to insulin, and is not due to metabolic or signalling defects within myocytes or liver." | ( Keske, MA; Premilovac, D; Rattigan, S; Richards, SM, 2014) |
| "Insulin resistance is also a significant predictor of poor outcome in patients admitted with ACS." | ( Balachander, J; Kadhiravan, T; Rajappa, M; Singh, P; Sridhar, MG, 2014) |
| "Insulin resistance is common in patients with chronic liver disease (CLD)." | ( Adams, DH; Claridge, L; Fear, J; Garg, A; Karim, S; Lalor, PF; Liaskou, E; Newsome, PN; Reynolds, G, 2014) |
| "Insulin resistance is also common in OSA, but its contribution to dyslipidemia of OSA is unclear." | ( Abbasi, F; Ariel, D; Cardell, J; Grove, K; Holmes, TH; Kim, SH; Kushida, CA; Lamendola, C; Liu, A; Mojaddidi, H; Reaven, GM; Tomasso, V, 2015) |
| "Insulin resistance is a significant factor in the development of type 2 diabetes mellitus, however the connection between the Western diet and the development of insulin resistance has not been fully explained." | ( Deer, J; Koska, J; Ozias, M; Reaven, P, 2015) |
| "Insulin resistance is an important risk factor for the development of several cardiac pathologies, thus advocating strategies for restoring insulin sensitivity of the heart in these conditions." | ( Angin, Y; Coumans, WA; Franekova, V; Glatz, JF; Hoebers, NT; Larsen, TS; Luiken, JJ; Simons, PJ, 2015) |
| "Insulin resistance is a cardinal feature of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, ageing and steroid use, among others." | ( Epstein, CB; Evertts, A; Garcia, BA; Griffin, MJ; Issner, R; Kang, S; Mikkelsen, TS; Rosen, ED; Tsai, LT; Whitton, HJ; Xu, S; Zhou, Y, 2015) |
| "Obesity-associated insulin resistance is a major pathogenesis of type 2 diabetes mellitus and is characterized by defects in insulin signaling." | ( Akagawa, M; Ishii, M; Maeda, A; Tani, S, 2015) |
| "Insulin resistance is a risk factor for type 2 diabetes, and is associated with inflammatory cardiometabolic disease." | ( Ferguson, JF; Mehta, NN; Reilly, MP; Rickels, MR; Shah, R; Shah, RY, 2015) |
| "Hepatic insulin resistance is associated with increased collagen." | ( Bracy, DP; Grueter, C; James, FD; Kang, L; Pozzi, A; Wasserman, DH; Williams, AS; Zheng, J, 2015) |
| "In conclusion, insulin resistance is the primary cause of tacrolimus-induced NODAT." | ( Cai, JJ; Chen, QJ; Cheng, K; Jia, SJ; Li, J; Liu, SK; Luo, AJ; Ming, YZ; Wang, JL; Xie, WZ; Yang, M; Yuan, H; Zhang, YP; Zuo, SR; Zuo, XC, 2015) |
| "Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes." | ( Anderson, KL; Blalock, EM; Brewer, LD; DeMoll, C; Gant, JC; Maimaiti, S; Porter, NM; Rauh, BA; Thibault, O, 2016) |
| "Insulin resistance is characterized by impaired biological response of peripheral tissues to the metabolic effects of insulin." | ( Alizadeh, A; Bahar, A; Hashemi-Soteh, MB; Kashi, Z; Mahrooz, A; Masoumi, P, 2015) |
| "Insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes mellitus (T2DM)." | ( Li, F; Liu, F; Ma, XJ; Qin, GJ; Shao, MW; Wu, LN; Zhang, HH; Zhang, PY; Zhang, YH; Zhao, YY, 2015) |
| "Insulin resistance is associated with hypertension." | ( Soleimani, M, 2015) |
| "Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment." | ( Cai, W; Cappellucci, L; Collins, WR; Ghazarian, A; Kahn, CR; Kleinridders, A; Pothos, EN; Vienberg, SG, 2015) |
| "Insulin resistance is prevalent in women with polycystic ovary syndrome (PCOS), and plays a critical pathophysiologic role in both the metabolic and reproductive complications of PCOS." | ( Evans, WS; Mayer, SB; Nestler, JE, 2015) |
| "Insulin resistance is associated with blunted sympathetic nervous system (SNS) response to carbohydrate ingestion which may contribute to postprandial hypotension and impaired body weight homeostasis." | ( Dixon, JB; Eikelis, N; Grima, MT; Lambert, EA; Lambert, GW; Nestel, PJ; Richards, K; Sari, CI; Schlaich, MP; Straznicky, NE, 2015) |
| "Insulin resistance is a cardinal feature of Type 2 Diabetes (T2D), which accompanied by lipid accumulation and TNF-α overexpression in skeletal muscle." | ( Bakhtiyari, S; Haghani, K; Pashaei, S; Taheripak, G; Vakili, S, 2015) |
| "Insulin resistance is a strong predictor of the development of type 2 diabetes mellitus." | ( de Ruiter, K; Djuardi, Y; Guigas, B; Houwing-Duistermaat, JJ; Martin, I; Mayboroda, OA; Sartono, E; Smit, JW; Soewondo, P; Supali, T; Tahapary, DL; Tasman, H; van Lieshout, L; Wiria, AE; Yazdanbakhsh, M, 2015) |
| "Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism is unclear." | ( Azuma, Y; Hu, X; Jung, DY; Kim, JH; Kim, JK; Kwon, JY; Lee, E; Lee, HJ; Lee, KW; Lee, Y; Patel, PR; Shafiq, U; Tsitsilianos, N; Wang, HF, 2015) |
| "Decreasing insulin resistance is a most desirable aim to be reached for an effective therapeutic/preventive action against metabolic syndrome and type 2 diabetes." | ( D'Archivio, M; Del Gaudio, I; Filesi, C; Galvano, F; Giovannini, C; Iacovelli, A; Masella, R; Pluchinotta, FR; Santangelo, C; Scazzocchio, B; Varì, R, 2015) |
| "The onset of insulin resistance is an important metabolic event in the development of type 2 diabetes." | ( Chapman, I; Heilbronn, L; Mahadi, MK; Nolting, M; Wilkinson, D, 2015) |
| "Insulin resistance is a fundamental aspect of the aetiology of type 2 diabetes." | ( Beletate, V; Braz, LG; do Nascimento, P; El Dib, R; Gameiro, OL; Jorge, EC; Módolo, NS; Ogata, MS, 2015) |
| "In addition, insulin resistance is commonly associated with PCOS and contributed to pathophysiology connected to dietary minerals including chromium (Cr), copper (Cu), iron (Fe), and zinc (Zn)." | ( Chen, TS; Chen, YT; Liu, CH; Mao, FC; Sun, CC, 2015) |
| "Insulin resistance is a common risk factor in chronic kidney disease patients contributing to the high cardiovascular burden, even in the absence of diabetes." | ( Andreoli, MC; Canziani, ME; Caramori, JC; Cassi, HV; da Silva, DR; de Andrade Bastos, K; de Campos, LG; de Moraes, TP; Divino-Filho, JC; Filho, SR; Olandoski, M; Pecoits-Filho, R; Pinto, SW; Ponce, D; Rio, DR, 2015) |
| "Insulin resistance is present in muscle microvasculature and this may contribute to decreased insulin delivery to, and action in, muscle." | ( Aylor, KW; Barrett, EJ; Cao, W; Fu, Z; Liu, Z; Wu, J; Zhao, L, 2015) |
| "Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose tissue." | ( James, J; Roy, D; Shihabudeen, MS; Thirumurugan, K, 2015) |
| "Insulin resistance is a common feature of obesity and predisposes individuals to various prevalent pathological conditions." | ( Cruces-Sande, M; Heijnen, CJ; Kavelaars, A; Lucas, E; Mayor, F; Murga, C; Vila-Bedmar, R; Willemen, HL, 2015) |
| "Insulin resistance is a prevalent condition commonly associated with unhealthy lifestyles." | ( Araya, V; Arrese, M; Aylwin, CG; Bezanilla, CG; Carrasco, E; Carrasco, F; Codner, E; Díaz, E; Durruty, P; Galgani, J; García, H; Lahsen, R; Lanas, A; Liberman, C; López, G; Maíz, A; Mujica, V; Pollak, F; Poniachik, J; Sapunar, J; Sir, T; Soto, N; Valderas, J; Villaseca, P; Zavala, C, 2015) |
| "Insulin resistance is a homeorhetic adaptation to parturition in dairy cows transitioning from late pregnancy to early lactation." | ( Bandaru, VV; Dorskind, JM; Haughey, NJ; McFadden, JW; Rico, JE, 2015) |
| "Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM)." | ( Gong, YZ; Liao, DF; Liu, HY; Wang, J; Xie, XJ; Yang, HX; Zou, T, 2015) |
| "Insulin resistance is closely associated with obesity and precedes the development of type 2 diabetes." | ( Kozan, P; Samocha-Bonet, D; Williams, RS, 2016) |
| "Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin." | ( Berggren, PO; Leibiger, B; Leibiger, IB; Lim, JH; Moede, T; Paschen, M; Pereira, T; Ryu, SH; Yunn, NO, 2015) |
| "Insulin resistance is one of the major factors contributing to metabolic diseases, but the underlying mechanisms are still poorly understood." | ( Chen, S; Deng, J; Guo, F; Guo, Y; Xiao, F; Yu, J, 2016) |
| "Insulin resistance is a serious health condition worldwide; however, its exact mechanisms are still unclear." | ( El-Awady, MS; Gameil, NM; Megahed, N; Sharawy, MH, 2016) |
| "Insulin resistance is closely related to inflammatory stress and the mammalian target of rapamycin/S6 kinase (mTOR/S6K) pathway." | ( Chen, Y; Moorhead, JF; Ruan, XZ; Varghese, Z; Yang, P; Yuan, J; Zhao, L; Zhao, Y, 2015) |
| "Skeletal muscle insulin resistance is a primary defect in the majority of patients with DM2." | ( Agrawal, DK; Chen, S; Villalta, SA, 2016) |
| "The lipid induced insulin resistance is a major pathophysiologic mechanism underlying glucose intolerance of varying severity." | ( Bhattacharjee, S; Das, N; Mandala, A; Mukhopadhyay, S; Roy, SS, 2015) |
| "Insulin resistance is a characteristic of PCOS patients and is more pronounced in obese patients." | ( Cappelli, V; De Leo, V; Di Sabatino, A; Massaro, MG; Morgante, G, 2015) |
| "Skeletal muscle insulin resistance is an early defect in the development of type 2 diabetes." | ( Funai, K; Klein, S; Lodhi, IJ; Semenkovich, CF; Song, H; Spears, LD; Yin, L, 2016) |
| "Obesity-induced insulin resistance is a major risk factor for the development of type 2 diabetes." | ( Houssier, M; Langin, D; Morigny, P; Mouisel, E, 2016) |
| "Insulin resistance is representative of these metabolic disorders, and not only leads to the development of diabetes but also affects the outcome of antiviral treatment with interferon." | ( Ogawa, E, 2015) |
| "Since insulin resistance is genetically determined and observed in type 1 diabetes, the study was designed to elucidate an involvement of Ala 12 Pro PPARg2 gene polymorphism in residual C-peptide secretion and BMI variation in children with type 1 diabetes." | ( Mianowska, B; Mlynarski, W; Pietrzak, I; Szadkowska, A; Wyka, K; Zmyslowska, A, 2015) |
| "Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake." | ( Denkaew, T; Mangmool, S; Nishida, M; Parichatikanond, W; Phosri, S; Pinthong, D; Shimauchi, T, 2016) |
| "Skeletal muscle insulin resistance is associated with many common age-related diseases, but moderate calorie restriction (CR) can substantially elevate glucose uptake by insulin-stimulated skeletal muscle from both young and old rats." | ( Arias, EB; Cartee, GD; Wang, H, 2016) |
| "Insulin resistance is associated with microalbuminuria among youth with diabetes mellitus." | ( Dabelea, D; Divers, J; Dolan, L; Imperatore, G; Maahs, DM; Marcovina, S; Mauer, M; Mayer-Davis, EJ; Mottl, AK; Pettitt, D; Pihoker, C, 2016) |
| "Insulin resistance is common in individuals with chronic kidney disease (CKD) and may be partly explained by modifiable risk factors." | ( Ärnlöv, J; Carrero, JJ; Cederholm, T; Lindholm, B; Qureshi, AR; Risérus, U; Sjögren, P; Xiong, Z; Xu, H, 2016) |
| "Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities." | ( Dong, J; He, Y; Wang, SS; Wang, W; Xiao, HB; Yan, YX; Zhao, J, 2016) |
| "Insulin resistance is the pathophysiological basis of many diseases." | ( Chen, C; Dong, SQ; Gu, MB; Li, HX; Liu, H; Liu, YQ; Luo, EF; Lv, HM; Xi, YL, 2016) |
| "Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear." | ( Burns, JM; Johnson, DK; Mahnken, JD; Montgomery, RN; Morris, JK; Thyfault, JP; Vidoni, ED, 2016) |
| "Insulin resistance is the characteristic of type 2 diabetes mellitus and metabolic disorder." | ( Hai, C; Liu, J; Liu, Y; Long, Z; Sun, Q; Wang, X; Wu, H, 2016) |
| "Markers of insulin resistance are strongly related with markers of iron metabolism in healthy subjects." | ( Aeschbacher, S; Assadian, M; Conen, D; Estis, J; Kofler, T; Krisai, P; Leib, S; Maseli, A; Risch, L; Risch, M; Todd, J, 2016) |
| "The development of insulin resistance is closely related with the increased levels of TC, TG, BMI, WHR, and BUA." | ( Cheng, YX; Fan, YJ; Hu, XQ; Huang, Q; Jiang, M; Li, SY; Liu, L; Liu, XY; Ma, R; Ma, YY; Wang, PP; Wang, ZZ; Yao, TY; Yu, JJ; Zhang, JL, 2016) |
| "Emerging insulin resistance is normally compensated by increased insulin production of pancreatic β-cells, thereby maintaining normoglycemia." | ( Chen, C; Chmelova, H; Chouinard, JA; Cohrs, CM; Jahn, SR; Speier, S; Stertmann, J; Uphues, I, 2016) |
| "TGF-β1-induced insulin resistance is suppressed by AMPK agonists and the constitutively active AMPK in 3T3L1 adipocytes." | ( Fry, J; Han, J; Jiang, B; Li, Q; Luo, T; Nocon, A; Rui, X; Sherban, A; Xu, XJ; Yan, Y; Yang, Q; Zang, M, 2016) |
| "Diet-induced muscle insulin resistance is associated with expansion of extracellular matrix (ECM) components, such as collagens, and the expression of collagen-binding integrin, α2β1." | ( Bracy, DP; Hennayake, C; James, FD; Kang, L; Lark, DS; Mokshagundam, S; Pozzi, A; Reuter, B; Sneddon, CC; Wasserman, DH; Williams, AS; Zent, R, 2016) |
| "Insulin resistance is considered to play an important role in the associations between DM and dementia." | ( Luo, YJ; Xiao, J; Ye, F; Yi, G; Yu, NW, 2016) |
| "Insulin resistance is a powerful predictor of cardiovascular disease; however, the mechanistic link remains unclear." | ( D'Angelo, G; Fulton, DJ; Mintz, JD; Stepp, DW; Thompson, JA, 2016) |
| "Insulin resistance is associated with cardiovascular diseases although the precise mechanisms remain elusive." | ( Ren, J; Wang, Q, 2016) |
| "Insulin resistance is a metabolic disorder which affects the diabetes mellitus pathophysiology and alters the cell excitability." | ( Ahmadvand, H; Nakhaie, A; Samadi Noshahr, Z; Shahraki, MR, 2016) |
| "Insulin resistance is known to be a risk factor for cognitive impairment, most likely linked to insulin signaling, microglia overactivation, and beta amyloid (Aβ) deposition in the brain." | ( Gad, ES; Moustafa, YM; Zaitone, SA, 2016) |
| "Insulin resistance is correlated with the progress of albuminuria in diabetic patients, and podocytes are crucial for maintaining the normal function of the glomerular filtration barrier." | ( Chen, L; Li, Z; Wan, Q; Xin, W; Xu, Y; Yu, Y; Zhou, Q, 2016) |
| "Insulin resistance is associated with deregulation of insulin signaling owing to the chronic exposure of insulin (hyperinsulinemia) to the tissues." | ( Beg, M; Gaikwad, AN; Gupta, A; Kumar, D; Rajan, S; Shankar, K; Srivastava, A; Varshney, S, 2016) |
| "Insulin resistance is a characteristic feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling." | ( Bhakta, HK; Choi, JS; Jung, HA; Min, BS, 2016) |
| "Insulin resistance is associated with mitochondrial dysfunction and decreased ATP synthesis." | ( Abdul-Ghani, M; Daniele, G; DeFronzo, RA; Eldor, R; Merovci, A; Norton, L; Solis-Herrera, C; Tripathy, D; Xiong, J, 2016) |
| "Insulin resistance is associated with increased oxidative stress and the NADPH oxidase enzyme plays an important role." | ( Carpinelli, AR; Carvalho, DS; Cavanal, MF; da Silva Alves, E; Diniz, MM; Gil, FZ; Haidar, AA; Hirata, AE, 2016) |
| "Insulin resistance is the main cause of type 2 diabetes and hyperglycemia." | ( Akopyan, Z; Blasi, F; Kulebyakin, K; Penkov, D; Tkachuk, V, 2016) |
| "Insulin resistance is the main characteristic of T2DM, which may be due to impairment of the PI3K/AKT signaling pathway." | ( Bian, H; Chen, Q; Jing, Y; Kong, X; Kuai, M; Li, Y; Lin, C; Lu, Y; Ma, Z; Sun, X; Wu, X, 2016) |
| "Insulin resistance is a major metabolic abnormality in a large majority of patients with type II diabetes." | ( Hou, W; Mo, W; Sun, R; Sun, Z; Wang, Y; Wei, H; Wu, Y; Yu, M, 2017) |
| "Obesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease (AD)." | ( McLimans, KE; Willette, AA, 2017) |
| "Insulin resistance is a critical factor in the development of metabolic disorders, including type 2 diabetes (T2DM)." | ( Gao, L; Li, D; Liu, B; Lu, H; Lu, Y; Wu, Z; Xiong, X, 2017) |
| "Insulin resistance is currently recognized by the estimated glucose disposal rate." | ( Abdelsalam, MM; Ahmed, IZ; Eid, YM; Mahdy, MM; Mansour, HK; Sheriba, NA, 2018) |
| "Insulin resistance is common among obese adolescents; however, the extent of this problem is not clear." | ( Benites-Zapata, VA; Hernandez, AV; Pasupuleti, V; Perez-Lopez, FR; Thota, P, 2017) |
| "The development of insulin resistance is multifactorial, with maternal pre- and postnatal nutrition having significant influences." | ( Adamu, HA; Esa, NM; Imam, MU; Ismail, M; Ooi, DJ; Rosli, R, 2017) |
| "Insulin resistance is a risk factor for type 2 diabetes mellitus." | ( Howles, P; Li, X; Tso, P; Wang, F; Xu, M, 2017) |
| "Insulin resistance is an independent cardiovascular risk factor and induces endothelial dysfunction by increasing fatty acid oxidation." | ( Antoniadi, G; Eleftheriadis, T; Liakopoulos, V; Pissas, G; Rountas, C; Sounidaki, M; Stefanidis, L, 2017) |
| "Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function." | ( Chu, Y; Hou, J; Li, N; Lin, L; Liu, P; Sun, C; Wang, X; Yu, H, 2017) |
| "Prevalence of insulin resistance is increased in patients with obstructive sleep apnea (OSA)." | ( Abbasi, F; Ariel, D; Cardell, J; Grove, K; Kim, SH; Kushida, CA; Lamendola, C; Liu, A; Mojaddidi, H; Patel, S; Reaven, GM; Tomasso, V; Tsao, PS; Xu, S, 2017) |
| "Insulin resistance is highly prevalent among patients with atherosclerosis and is associated with an increased risk for myocardial infarction (MI) and stroke." | ( Abbott, JD; Conwit, R; Curtis, JP; Furie, KL; Gorman, MJ; Inzucchi, SE; Jacoby, DL; Kernan, WN; Kolansky, DM; Ling, FS; Lovejoy, AM; Pfau, SE; Schwartz, GG; Viscoli, CM; Young, LH, 2017) |
| "Insulin resistance is believed to be the key mechanism mediating initial accumulation of fat in the liver, resulting in hepatic steatosis." | ( Chen, Y; Li, G; Wang, N; Zhang, W; Zhou, F, 2017) |
| "Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets that leads to type 2 diabetes." | ( Bilan, PJ; Boroumand, P; Chan, KL; Costford, SR; Escalante, NK; Fine, N; Girardin, SE; Glogauer, M; Klip, A; Liu, Z; Philpott, DJ; Prabaharan, D; Prescott, D; Robertson, SJ; Salter, MW; Tam, TH; Tu, Y, 2017) |
| "Insulin resistance is a major health risk, and although exercise clearly improves skeletal muscle insulin sensitivity, the mechanisms are unclear." | ( Betik, AC; Frøsig, C; Kiens, B; Kjøbsted, R; Kleinert, M; McConell, GK; Rattigan, S; Richter, EA; Shaw, CS; Sjøberg, KA; Sylow, L; Wojtaszewski, JFP, 2017) |
| "Insulin resistance is a well-known risk factor for obesity, metabolic syndrome (MetSyn) and associated cardiovascular diseases, but its mechanisms are undefined in the lymphatics." | ( Chakraborty, S; Fluckey, JD; Lee, Y; Muthuchamy, M, 2017) |
| "Insulin resistance is a main pathogenic event in Type 2 Diabetes Mellitus (T2DM) leading to a reduction in glucose uptake by peripheral tissue and increased hepatic glucose output." | ( Khanna, A; Mokashi, P; Pandita, N, 2017) |
| "Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease." | ( Bissoli, NS; Cattafesta, M; Molina, MDCB; Salaroli, LB; Zandonade, E, 2017) |
| "Since insulin resistance is increased in AD neurons, we investigated the effects of APO on brain insulin resistance in 3xTg-AD mice at early and late stages." | ( Iinuma, KM; Imamura, T; Kira, JI; Murai, H; Nakamura, N; Ohyagi, Y; Soejima, N; Yamasaki, R; Yanagihara, YT, 2017) |
| "Insulin resistance is one of important factors which could play critical roles in DM pathogenesis." | ( Alonso-Iglesias, E; Codoñer-Franch, P; Esfandiary, E; Mirzaei, H; Saeedi Borujeni, MJ; Taheripak, G, 2018) |
| "Insulin resistance is central to the development of type 2 diabetes and related metabolic disorders." | ( Åhlin, M; Massart, J; Riedl, I; Ruby, MA; Zierath, JR, 2017) |
| "Insulin resistance is important in dairy cattle, causing ketosis and fatty liver." | ( Smith, SB, 2017) |
| "Insulin resistance is a core feature of the MetS." | ( de Abreu, VG; de Oliveira, PAC; Francischetti, EA; Martins, CJM, 2017) |
| "Insulin resistance is a key feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling." | ( Luo, J; Shi, D; Wu, N; Xu, Q; Zhang, R, 2018) |
| "Insulin resistance is generally responsible for the pathogenesis of type 2 diabetes mellitus (T2DM)." | ( Cheng, J; Ding, Y; Du, Y; Lu, A; Lu, L; Meng, C; Yao, Q; Ye, X; Yu, W; Zhao, Z, 2018) |
| "Skeletal muscle insulin resistance is known to play an important role in the pathogenesis of diabetes, and one potential causative cellular mechanism is endoplasmic reticulum (ER) stress." | ( Ahlstrom, P; Chakma, S; Cho, HH; Rai, E; Rengasamy, P; Sweeney, G, 2017) |
| "Insulin resistance is a major predictor of the development of metabolic disorders." | ( Cavadas, C; Costa, V; de Oliveira, RM; Gomes, P; Lemos, V; Magro, F; Naia, L; Outeiro, TF; Pinho, S; Ramos, E; Rego, AC; Szegö, É, 2017) |
| "Insulin resistance is a major risk factor for type 2 diabetes." | ( Choe, C; Ciaraldi, TP; Farr, O; Henry, RR; Hwang, WM; Kang, MC; Kim, SS; Kim, YB; Lim, DM; Mantzoros, C; Park, KS; Seo, JA, 2018) |
| "Insulin resistance is a major defect underlying type 2 diabetes development." | ( Athipornchai, A; Chiabchalard, A; Nooron, N; Suksamrarn, A, 2017) |
| "Since insulin resistance is a hallmark in the development of type 2 diabetes mellitus, this study aimed at investigating if zinc supplementation is able to improve glucose tolerance and β-cell function in a model of insulin resistance." | ( Abdulkader, F; Carpinelli, AR; Cooper-Capetini, V; de Vasconcelos, DAA; Donato, J; Hirabara, SM; Martins, AR, 2017) |
| "Insulin resistance is a hallmark of diabetes and an unmet clinical need." | ( Accili, D; Aizawa, K; Buettner, C; Cook, JR; Ericson, E; Haeusler, RA; Johansson, A; Langlet, F; Lindén, D; Norris, T; Wang, L, 2017) |
| "Insulin resistance is closely linked to the development and progression of renal disease." | ( Geraldes, P, 2018) |
| "Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear." | ( Bai, Y; Barati, MT; Cai, L; Dai, X; Epstein, PN; Gu, J; Li, X; Li, Y; Lin, Q; Tan, Y; Wang, K; Wang, Y; Wintergerst, KA; Xiao, J; Xin, Y; Yan, X; Zeng, J; Zhang, C; Zhang, J; Zhou, S, 2018) |
| "Insulin resistance is the hallmark of type 2 diabetes; however, the mechanism underlying the development of insulin resistance is still not completely understood." | ( He, L; Peng, J, 2018) |
| "Insulin resistance is one of the most common and important pathological features of type 2 diabetes (T2D)." | ( Dong, L; Han, Q; Han, W; Hao, H; Liu, J; Mu, Y; Song, X; Sun, X, 2017) |
| "Obesity based on insulin resistance is a state of chronic oxidative stress and inflammation that are highly regulated through nuclear factor Erythroid 2-related factor 2 (NrF2) pathway." | ( Abo El-Magd, NF; El-Karef, A; El-Mesery, M; El-Shishtawy, MM, 2018) |
| "Insulin resistance is at the core of the metabolic syndrome, and men exhibit a higher incidence of metabolic syndrome than women in early adult life, but this sex advantage diminishes sharply when women reach the postmenopausal state." | ( Bosch, MA; Kelly, MJ; Meza, C; Navarro, UV; Nestor, CC; Qiu, J; Rønnekleiv, OK; Wagner, EJ, 2018) |
| "Insulin resistance is a challenging integrally related topic and molecules capable of overcoming it are of considerable therapeutic interest in the context of type 2 diabetes mellitus (T2DM)." | ( Ali, MY; Choi, JS; Jung, HA; Jung, HJ; Min, BS; Seong, SH, 2017) |
| "On the other hand, insulin resistance is the main cause of type 2 diabetes, which develops in parallel with changes in the pancreas." | ( Kasacka, I; Nowińska, P, 2017) |
| "The causes of insulin resistance are not well-understood in either type 1 or type 2 diabetes." | ( Rhinesmith, T; Root-Bernstein, R; Turkette, T, 2017) |
| "Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes." | ( Kokkola, T; Laakso, M; Modi, S; Yaluri, N, 2017) |
| "Insulin resistance is a major factor in type II diabetes development, occurring when insulin levels are normal, but do not have normal interactions with adipose, muscle or liver tissue." | ( Chang, SL; Chang, SW; Chen, YI; Chung, YC; Ho, WJ; Hsu, TH; Hung, PH; Kuo, YH; Tzeng, CY, 2018) |
| "Insulin resistance is induced by treating L6 cells with 1 μm angiotensin II (Ang II) for 24 h." | ( Chan, CB; Son, M; Wu, J, 2018) |
| "Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN)." | ( An, XR; Jin, SJ; Li, XX; Wei, W; Xu, M, 2018) |
| "Insulin resistance is often characterized as the most critical factor contributing to the development of (T2D) type 2 diabetes." | ( Chen, L; Dong, Y; Du, X; Gao, W; Lei, L; Li, X; Liu, G; Shi, Z; Wang, Z; Zhang, M, 2018) |
| "Insulin resistance is a major risk factor for metabolic diseases such as Type 2 diabetes." | ( Chaudhuri, R; Fazakerley, DJ; Fisher-Wellman, KH; Hoehn, KL; James, DE; Krycer, JR; Kuncic, Z; Su, Z; Vafaee, F; Yang, JYH, 2018) |
| "Insulin resistance is the major driver of T2D manifesting long before insulin secretion failure." | ( Casella Mariolo, J; Castagneto Gissey, L; Mingrone, G, 2018) |
| "Insulin resistance is reflected by the rates of reduced glucose uptake (GU) into the key insulin-sensitive tissues, skeletal muscle, liver and adipose tissue." | ( Bucci, M; Hannukainen, JC; Honka, MJ; Kalliokoski, KK; Latva-Rasku, A; Nuutila, P; Virtanen, KA, 2018) |
| "Inflammation and insulin resistance are also suppressed by silencing expression of caveolin-1 or PAR2 in ATMs; these proteins mediate the actions of DPP4 and factor Xa, respectively." | ( Blüher, M; Chen, E; Czech, MP; Ghorpade, DS; Nicoloro, SM; Ozcan, L; Shen, Y; Tabas, I; Zheng, Z, 2018) |
| "Insulin resistance is directly correlated to the central mechanisms of hepatic steatosis in NAFLD patients, which is strongly correlated to the imbalance of the renin-angiotensin system, that is involved in lipid and glucose metabolism." | ( Borém, LMA; Brandi, IV; Lelis, DF; Neto, JFR; Santos, SHS, 2018) |
| "Insulin resistance is a risk factor for obesity and diabetes and predisposes individuals to Staphylococcus aureus colonization; however, the contribution of S." | ( Cheng, JH; Dong, FT; Feng, JN; Gao, YP; Guan, ZC; Han, DP; Li, D; Liu, CH; Liu, FJ; Liu, Y; Ma, CM; Shen, BF; Yan, J; Yang, G, 2018) |
| "Obesity and insulin resistance are associated with overexpression of retinaldehyde dehydrogenase 1 (RALDH1)." | ( Liu, L; Liu, X; Sun, B; Wang, S; Wang, Z; Xu, J; Yang, H; Zhang, M; Zhang, X; Zhou, Y, 2018) |
| "Fasting glucose and insulin resistance are risk factors for premature death and other adverse outcomes." | ( Carlson, OD; Chia, CW; Fabbri, E; Ferrucci, L; Gonzalez-Freire, M; Khadeer, M; Moaddel, R; Salem, N; Semba, RD; Sun, K; Zhang, P, 2018) |
| "Insulin resistance is associated with a poor prognosis in non‑alcoholic fatty liver disease (NAFLD) patients." | ( Kawaguchi, T; Nakano, D; Oriishi, T; Torimura, T, 2018) |
| "Insulin resistance is associated with low thyroid hormone levels in non-diabetic individuals." | ( Chang, TC; Huang, KC; Shih, SR; Wang, CY; Yu, TY, 2018) |
| "Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease." | ( Fazakerley, DJ; Hocking, SL; James, DE; Kearney, AL; Krycer, JR, 2019) |
| "Insulin resistance is frequently present in patients with glucocorticoid (GC) excess (Cushing's syndrome) or treated with high doses of GCs." | ( Bruno, F; Do, TTH; Guillaume, D; Héloïse, D; Marie, G; Marion, B; Marthe, M, 2019) |
| "Hepatic insulin resistance is a hallmark of type 2 diabetes and obesity." | ( Accili, D; Camastra, S; Ferrannini, E; Friedländer, MR; Haeusler, RA; Langlet, F; Tarbier, M, 2018) |
| "Insulin resistance is frequent in patients with multiple sclerosis and might contribute to metabolic complications and general disability." | ( Lozano, CD; Méndez-Huerta, MA; Ruiz-Argüelles, A; Ruiz-Argüelles, GJ, 2018) |
| "Insulin resistance is caused by various environmental and genetic factors leading to a number of serious health issues." | ( Aziz, AUR; Farid, S; Liu, B; Qin, K; Wang, H, 2020) |
| "Insulin resistance is a condition in which there is a defect in insulin actions to induce glucose uptake into the cells." | ( Mangmool, S; Nishida, M; Nishimura, A; Parichatikanond, W, 2018) |
| "Inflammation and insulin resistance is recently implicated in the pathogenesis of diabetic kidney injury." | ( Chen, Q; Chen, Y; Deng, L; Qiu, P; Wei, X; Xiao, J; Yan, C; Yang, Y; Zhan, X, 2018) |
| "Insulin resistance is a common feature of metabolic syndrome that may be influenced by genetic risk factors." | ( Daily, JW; Liu, M; Park, S, 2019) |
| "Adipose tissue insulin resistance is one of the pathophysiological components of type 2 diabetes." | ( Arslanian, S; Bacha, F; Kim, JY; Michaliszyn, SF; Tfayli, H; Yousuf, S, 2019) |
| "Hippocampal insulin resistance is the key factor in cognitive deficits." | ( Ma, D; Mu, J; Qin, S; Sun, D; Tang, R; Zheng, Y, 2019) |
| "Insulin resistance is a major pathophysiological feature in the development of type 2 diabetes." | ( Fan, X; Gu, D; Hou, Y; Jang, Y; Li, S; Su, Y; Tao, J; Wang, Y; Zhou, Y, 2019) |
| "Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality." | ( Kalsbeek, A; la Fleur, SE; Scheer, FAJL; Schrauwen, P; Stenvers, DJ, 2019) |
| "Insulin resistance is the main cause of type 2 diabetes." | ( Fan, Y; He, C; Meng, Y; Wang, N; Yan, J; Yang, L; Yang, S; Zhou, Y, 2019) |
| "Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to address glycemic control to prevent diabetic complications." | ( Atkin, SL; Sahebkar, A; Simental-Mendía, LE; Yaribeygi, H, 2019) |
| "Insulin resistance is the major hallmark of NAFLD and is crucial in the pathogenesis and for the progression from NAFLD to non-alcoholic steatohepatitis (NASH)." | ( Chao, HW; Chao, SW; Cheng, CF; Ku, HC; Lin, H, 2019) |
| "Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD)." | ( Chatterjee, S; Choubey, A; Daniel, PV; Dogra, S; Ghosh, D; Ghosh, S; Girdhar, K; Kar, AK; Mondal, P; Patnaik, S, 2019) |
| "However, insulin resistance is not commonly measured in clinical practice." | ( Dearborn-Tomazos, J; Ford, GA; Furie, KL; Gorman, M; Inzucchi, SE; Kernan, WN; Lovejoy, AM; Spence, JD; Viscoli, CM; Young, LH, 2019) |
| "Insulin resistance is involved with endothelial dysfunction by direct and indirect mechanisms that also promote vascular inflammation and atherosclerosis." | ( Agrawal, DK; Satish, M; Saxena, SK, 2019) |
| "Insulin resistance is associated with oxidative stress, mitochondrial dysfunction, and a chronic low-grade inflammatory status." | ( González-Muniesa, P; Lopez-Pascual, A; Lorente-Cebrián, S; Martinez, JA; Urrutia-Sarratea, A, 2019) |
| "Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified." | ( Baranowski, M; Dela, F; Greve Dideriksen, S; Larsen, S; Munk Scheuer, C; Søgaard, D; Taulo Lund, M; Vestergaard Abildskov, C; Wulff Helge, J, 2019) |
| "Decreased hepatic insulin resistance is key, but underlying mechanisms are poorly understood." | ( Pal, A; Rhoads, DB; Tavakkoli, A, 2019) |
| "Insulin resistance is believed to be an important determinant." | ( McCullough, PA; Rocha, NA; Zhang, J, 2018) |
| "Insulin resistance is a major contributing factor in the development of metabolic disease." | ( Dai, C; Ji, W; Qi, M; Wang, X; Wu, Y; Xu, Y; Zhan, L; Zhuo, S, 2019) |
| "Obesity-associated insulin resistance is a forerunner of type 2 diabetes." | ( Cheng, P; Liu, T; Shao, HG; Sun, YC, 2019) |
| "Insulin resistance is a pathology associated primarily with FA and secondarily with glucose." | ( Karganov, MY; Titov, VN, 2019) |
| "Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS)." | ( Craig, A; Issberner, J; Parvez, F, 2019) |
| "Obesity-related insulin resistance is associated with intramyocellular lipid accumulation in skeletal muscle." | ( Ahn, B; Ayer, DE; Han, X; Jaiswal, N; Kelly, DP; Titchenell, PM; Vega, RB; Wan, S; Won, KJ, 2019) |
| "Insulin resistance is a major contributor to the pathogenesis of nonalcoholic fatty liver disease." | ( Cao, H; Guo, X; Hu, G; Luo, J; Xing, C; Zhang, C; Zhuang, Y, 2019) |
| "Acute myocardial insulin resistance is an independent risk factor for patients who undergo cardiac surgery with cardiopulmonary bypass (CPB)." | ( Chen, T; Gu, C; Han, Y; Hu, S; Ma, H; Wang, Y; Wang, Z; Yin, Q; Zhao, T, 2019) |
| "Insulin resistance is considered one of risk reasons which lead to several metabolic diseases." | ( El-Kott, AF; El-Sayed, M; El-Zeftawy, M; ElBealy, ER; Elguindy, N; Ghareeb, D; Mahmoud, S; Saad, R, 2019) |
| "Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes." | ( Jang, HB; Kim, KY; Kim, WH; Lee, HJ; Park, KJ; Park, SI, 2019) |
| "Insulin resistance is associated with increased lipolysis and elevated concentrations of free fatty acids (FFA), which in turn contribute to impaired vascular function." | ( Aday, AW; Beckman, JA; Goldfine, AB; Gregory, JM, 2019) |
| "Insulin resistance is an independent negative predictor of outcome after elective surgery and increases mortality among surgical patients in intensive care." | ( Fuskevåg, OM; Gjessing, PF; Hagve, M; Hole, MJ; Irtun, Ø; Jansen, KM; Larsen, TS; Mollnes, TE, 2019) |
| "When insulin resistance is induced by diets, a greater activation of insulin signaling cascade has been reported, increased cardiotrophin-1 levels and liver glucokinase and glucose- 6-phosphatase activities, and a decreased fructose-1,6-biphosphatase activity." | ( Aguirre, L; Fernández-Quintela, A; Gómez-Zorita, S; Milton-Laskíbar, I; Portillo, MP; Xiao, J, 2021) |
| "Insulin resistance is a major factor in obesity-linked type 2 diabetes." | ( Bandyopadhyay, G; El Ouarrat, D; Isaac, R; Lackey, D; Lee, YS; Oh, DY; Olefsky, JM; Riopel, M; Sampath-Kumar, R; Seo, JB; Wollam, J, 2020) |
| "If insulin resistance is detected earlier, lifestyle changes could prevent or delay disease development." | ( Barac, M; Bogdanović Radović, I; Hadžija, M; Popović Hadžija, M; Siketić, Z, 2020) |
| "Insulin resistance is a metabolic state where insulin sensitivity is lower than normal condition and strongly related to type 2 diabetes." | ( Choi, KJ; Jung, WH; Kang, D; Kim, KY; Koh, B; Lee, DM; Lee, S; Na, YJ; Park, SB; Yoo, HM, 2020) |
| "Excess insulin resistance is considered the predominant pathophysiological mechanism in obese women who develop gestational diabetes (GDM)." | ( Begum, S; Lawlor, DL; Nelson, SM; Pasupathy, D; Poston, L; Sattar, N; Seed, P; Vieira, MC; Welsh, P; White, SL, 2020) |
| "Inflammation and insulin resistance are involved in the development of the disease." | ( Bao, S; Cao, Y; Hou, H; Yang, W, 2020) |
| "Insulin resistance is a worldwide health problem." | ( El-Fayoumi, SH; Fahmy, A; Ibrahim, IAAE; Mahmoud, AAA, 2020) |
| "Insulin resistance is a determinant of diabetes, and regular eating patterns are an important factor in blood sugar control." | ( Jang, SI; Joo, HJ; Kim, GR; Park, EC, 2020) |
| "Insulin resistance is becoming an increasingly studied target for therapy, most evidence stemming from the time-honored metformin use." | ( Catellani, C; Cirillo, F; Dauriz, M; Lazzeroni, P; Moghetti, P; Sartori, C; Street, ME, 2020) |
| "Insulin resistance is a common phenomenon in diabetes but the exact mechanism remains unknown." | ( Khan, MWA; Khan, WA; Malik, A, 2020) |
| "Insulin resistance is one major features of type 2 diabetes mellitus (T2DM)." | ( Liang, Y; Su, Y; Wang, K; Wang, L, 2020) |
| "Excess GC-induced insulin resistance is mediated by increased association of GR with PI3K and treatment with HGSD attenuates these effects." | ( Chen, L; Guan, F; Hatch, GM; Lv, X; Meng, Z; Yang, X; Yu, Y; Zhang, M; Zhang, Y, 2020) |
| "Insulin resistance is a common link in the development of these conditions, and hyperinsulinemia is a central hallmark of peripheral insulin resistance." | ( Choubey, A; Ghosh, D; Girdhar, K; Kar, AK; Kushwaha, S; Mondal, P; Yadav, MK, 2020) |
| "Insulin resistance is associated with impaired glucose uptake, resulting from defective post-receptor insulin responses, decreased glucose transport, impaired glucose phosphorylation, oxidation and glycogen synthesis in the muscle." | ( Baba, SP; Posa, DK, 2020) |
| "Insulin resistance is the strongest predictor of liver fibrosis stage and hepatic inflammation in patients with alcohol-related liver disease." | ( Detlefsen, S; Fernandes Jensen, MJ; Hansen, T; Israelsen, M; Juel, HB; Kjærgaard, M; Krag, A; Larsen, TR; Madsen, BS; Rasmussen, DN; Stender, S; Thiele, M, 2022) |
| "Insulin resistance is suggested to have negative effects on cognition; however, results from large population studies are lacking." | ( Han, K; Hong, S; Park, CY, 2021) |
| "Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease." | ( Chang, Y; Kim, CK; Kim, MK; Oh, K; Seo, WK, 2021) |
| "Whereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between insulin resistance and brain glucose metabolism remains controversial." | ( Bertoldo, A; Bucci, M; Ferrannini, E; Hannukainen, JC; Heinonen, I; Hirvonen, J; Iozzo, P; Karjalainen, T; Laakso, M; Latva-Rasku, A; Nummenmaa, L; Nuutila, P; Oikonen, V; Parkkola, R; Rebelos, E; Virtanen, KA, 2021) |
| "Obesity-associated insulin resistance is generalised across all major muscles, and is not caused by alterations in muscle fibre type composition or perfusion." | ( Gropler, RJ; Klein, S; Koh, HE; Laforest, R; Meyer, GA; Mittendorfer, B; van Vliet, S, 2021) |
| "Insulin resistance is an essential characteristic of type 2 diabetes mellitus (T2DM), which can be induced by glucotoxicity and adipose chronic inflammation." | ( Chen, MT; Han, Q; Li, M; Xiao, XH; Zhang, Q; Zhao, YT; Zhou, LY, 2021) |
| "Insulin resistance is a common feature of type 2 diabetes mellitus (T2DM)." | ( Cao, P; Chen, W; Gan, D; Hou, Y; Hu, L; Li, G; Wu, J; Zhou, M, 2021) |
| "Typically, insulin resistance is considered as a decrease in sensitivity or responsiveness to the metabolic actions of insulin including insulin-mediated glucose disposal." | ( Hill, MA; Jia, G; Parrish, AR; Sowers, JR; Sun, Z; Yang, Y; Zhang, L, 2021) |
| "Insulin resistance is an under-recognised metabolic defect and cardiovascular risk factor in Type 1 diabetes." | ( Bruce, C; Evans, J; Greenfield, JR; Holmes-Walker, DJ; Kowalski, G; Liu, Z; Samocha-Bonet, D; Snaith, JR, 2021) |
| "Hepatocyte insulin resistance is one of the early factors of developing type II diabetes." | ( Dokukina, IV; Grachev, EA; Samarina, EA; Tilinova, OM; Yamashev, MV, 2021) |
| "Insulin resistance is defined as a complex pathological condition of abnormal cellular and metabolic response to insulin." | ( Roszczyc-Owsiejczuk, K; Zabielski, P, 2021) |
| "Glucose-induced insulin resistance is a typical character of diabetes." | ( Guan, G; He, C; He, T; Liu, P; Liu, Z; Pan, S; Wang, J; Zhang, Y; Zhao, N; Zhu, H; Zhu, L, 2021) |
| "Insulin resistance is a major risk factor for coronary artery disease (CAD)." | ( Chen, H; Dai, H; Fu, Q; Gu, Y; Sun, M; Yang, T; Zhang, M; Zhou, N, 2021) |
| "Obesity-induced insulin resistance is the principal cause of type 2 diabetes worldwide." | ( Feng, B; Feng, W; Huang, B; Jing, Y; Meng, R; Shen, S; Wang, W; Zhu, D, 2021) |
| "Insulin resistance is a pathophysiological condition associated with diabetes and cardiometabolic diseases that is characterized by a diminished tissue response to insulin action." | ( Chung, ST; Haymond, MW; Matta, ST; Sharma, VR, 2020) |
| "Insulin resistance is a key etiological factor in promoting not only type 2 diabetes mellitus but also cardiovascular disease (CVD)." | ( Bhatti, S; Buckman, JF; Malin, SK; Piersol, KL; Remchak, ME; Spaeth, AM, 2021) |
| "Insulin resistance is defined as a failure to trigger the activation of the PI3K-AKT pathway by normal levels of insulin; therefore, it is well linked to metabolic disorders." | ( Imoto, M; Itoh, S; Nagasawa, Y; Tashiro, E, 2021) |
| "Insulin resistance is caused by a combination of genetic and environmental factors." | ( Birnbaum, MJ; James, DE; Stöckli, J, 2021) |
| "Insulin resistance is an independent risk factor for developing type 2 diabetes." | ( Lee, HS; Lee, JH; Lee, YJ; Park, HM, 2021) |
| "The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world." | ( Ahmad, S; Alghamdi, S; Ali, N; Ali, R; Aman, A; Bannunah, AM; Hussain, H; Khan, J; Rahman, SU; Sahibzada, MUK; Ullah, A, 2021) |
| "Insulin resistance is a cornerstone of obesity-related complications such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease." | ( Cha, HN; Choi, SH; Choi, W; Choi, WG; Hwang, I; Kim, H; Lee, SY; Lee, YK; Lim, A; Oh, TJ; Park, SY; Ryu, D; Shin, H; Suh, JM, 2021) |
| "Insulin resistance is the common pathophysiological basis of metabolic syndrome." | ( Cai, G; Hou, L; Hu, CY; Huang, B; Jiang, F; Jiang, Y; Liu, D; Wang, C; Zheng, W, 2021) |
| "Insulin resistance is known as the hallmark of PCOS that leads to hyperinsulinemia and type 2 diabetes in PCOS patients." | ( Farahvash, T; Nejati, A; Shahri, MPK, 2022) |
| "Insulin resistance is recognized as a common contributor to diabetes and nonalcoholic fatty liver disease (NAFLD)." | ( Chen, G; Chen, X; Gu, X; Hu, X; Li, Q; Pan, W; Wen, J; Xu, K; Yang, L; Yu, W; Zhang, X; Zhang, Y, 2022) |
| "Central obesity and insulin resistance are associated with metabolic syndrome (MetS) which is aggravated by diet and sedentary lifestyle." | ( Engwa, GA; Mokwena, MAM; Nkeh-Chungag, BN; Sewani-Rusike, CR, 2021) |
| "Hypothalamic insulin resistance is known to precede that in the periphery, thus a critical unanswered question is whether central insulin resistance creates a specific hypothalamic miRNA signature that can be identified and targeted." | ( Belsham, DD; Chalmers, JA; Dalvi, PS; Dash, S; Eversley, JA; Loganathan, N; McIlwraith, EK; Mohan, H; Nazarians-Armavil, A; Stahel, P; Wellhauser, L; Wheeler, MB, 2022) |
| "Microvascular insulin resistance is present in metabolic syndrome and may contribute to increased cardiovascular disease risk and the impaired metabolic response to insulin observed." | ( Barrett, EJ; Hartline, L; Jahn, LA; Liu, Z, 2022) |
| "SDB and insulin resistance are associated in early pregnancy, with a dose response association between respiratory event index severity and insulin resistance." | ( Bai, A; Bourjeily, G; Bublitz, MH; Catalano, P; Mehta, N; Messerlian, GM; Sanapo, L, 2022) |
| "Insulin resistance is related closely to metabolic syndrome (MetS)." | ( Han, JH; Lee, HS; Lee, JH; Lee, YJ; Son, DH, 2022) |
| "Their activities in insulin resistance are dependent on the derivatives and corresponding receptors." | ( Jin, X; Lian, H; Liu, K; Ye, J; Zhang, X, 2022) |
| "Insulin resistance is the primary cause of type 2 diabetes." | ( Abdelsaid, M; Alexander, M; Fontenot, J; Greenway, F; Grimes, RM; Hepford, SA; Lakey, JRT; Lewis, ST; Loveridge, B; Nobles-James, C; Starr, AM; Tucker, TR; Wilson, C, 2022) |
| "Insulin resistance is considered to be closely associated with reduced testosterone levels and cognitive function." | ( Chen, L; Dong, F; He, Y; Hu, X; Huang, H; Liu, X; Min, J; Shuang, Z; Tian, S; Wang, P; Wang, W; Zeng, T; Zhang, J; Zhang, L; Zhang, Q, 2022) |
| "Insulin resistance is a major public health burden that often results in other comorbidities including type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease." | ( About, GB; Champy, MF; Coyne, ES; Ding, X; Goldstein, J; Jacobs, H; Jensen-Cody, S; Rosahl, TW; Sebin, A; Talukdar, S; Vogel, J; Zhou, HH; Zhou, Y, 2022) |
| "Insulin resistance is accelerated by obesity and is accompanied by accumulation of dysfunctional adipose tissues." | ( Inagaki, N; Kondoh, H; Murakami, T, 2022) |
| "Central insulin resistance is considered as one of the pathological hallmarks of Alzheimer's disease (AD), similar to formation of amyloid plaques and neurofibrillary tangles (NFT)." | ( Chopra, K; Dhaliwal, J; Kondepudi, KK; Ray, RS; Yadav, M; Yadav, S; Yamini, P, 2022) |
| "Insulin resistance is among the key risk factors for the development of non-alcoholic fatty liver disease (NAFLD)." | ( Baumann, A; Bergheim, I; Brandt, A; Burger, K; Jung, F; Lorenzo Pisarello, MJ; Rajcic, D; Staltner, R, 2022) |
| "Insulin resistance is a characteristic feature of type 2 diabetes." | ( Gao, Y; Liu, J; Ma, X; Thring, RW; Tong, H; Wu, M; Wu, Q; Zhang, Y; Zhang, Z; Zhu, J, 2022) |
| "Insulin resistance is a metabolic disorder characterized by the decreased response to insulin in muscle, liver, and adipose cells." | ( Fadilah, F; Purwaningsih, EH; Yuliana, ND; Zuhri, UM, 2022) |
| "Insulin resistance is key in the pathogenesis of the metabolic syndrome and cardiovascular disease." | ( Aguilar-Salinas, CA; Alfaro-Pastrana, R; Almeda-Valdés, P; Bello-Chavolla, OY; Cano-Castillo, J; Crespo-Morfin, PB; Cruz-Bautista, I; Gómez-Pérez, FJ, 2022) |
| "Skeletal muscle insulin resistance is a key pathophysiological process that precedes the development of type 2 diabetes." | ( Bakker, BM; Gerding, A; Homan, E; Huijkman, N; Langelaar-Makkinje, M; Li, Z; Reijngoud, DJ; Rensen, PCN; Rios-Morales, M; Vieira-Lara, MA; Wolters, JC, 2022) |
| "Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to the genesis of vascular disease and glycemic dysregulation." | ( Jurrissen, TJ; Manrique-Acevedo, C; Martinez-Lemus, LA; McMillan, NJ; Padilla, J; Smith, JA; Soares, RN, 2022) |
| "Systemic insulin resistance is characterized by reduced insulin metabolic signaling and glucose intolerance." | ( Hill, MA; Igbekele, AE; Jia, G; Sowers, JR, 2022) |
| "Insulin resistance is an underlying condition prior to the development of several diseases, including type 2 diabetes, cardiovascular diseases, cognitive impairment, and cerebrovascular complications." | ( Chattipakorn, N; Chattipakorn, SC; Pintana, H; Pratchayasakul, W; Seesen, M, 2022) |
| "Insulin resistance is present in non-diabetic patients undergoing maintenance hemodialysis (MHD) and is an important factor leading to sarcopenia." | ( Chen, R; Jin, H; Li, Z; Liu, B; Liu, D; Liu, H; Wang, Y; Zhang, L; Zhang, M; Zhang, X, 2022) |
| "Obesity and insulin resistance are significant contributors to hypertension." | ( Guo, H; Guo, S; He, J; He, X; Li, Y; Liao, S; Ma, R; Mao, Y; Rui, D; Sun, X; Yan, Y; YuSong, D, 2022) |
| "Insulin resistance is an important cause of cardiovascular events and cerebral infarction development." | ( Cai, X; Jin, A; Jing, J; Li, S; Mei, L; Meng, X; Pan, Y; Wang, M; Wang, S; Wang, Y; Wei, T, 2022) |
| "Insulin resistance is a risk factor for type 2 diabetes and is often associated with obesity." | ( Jia, X; Liu, W, 2022) |
| "Insulin resistance is a common feature of obesity and type 2 diabetes and partly results from an imbalance between food intake and energy expenditure." | ( Han, S; Han, Y; Huang, R; Li, Z; Qin, X; Wang, T; Wang, X; Wang, Y; Wu, J; Xia, B; Xiang, Y; Yang, G, 2023) |
| "Since muscle insulin resistance is the primary defect in T2D, we aimed to determine whether BPA alters glucose metabolism in L6 muscle cells." | ( Aguer, C; Amrouche-Mekkioui, I; Belhadji-Domecq, M; Kasongo, AA; Leroux, M, 2022) |
| "Obesity-induced insulin resistance is the fundamental cause of metabolic syndrome." | ( Lee, BC; Lee, HY; Noh, JW, 2022) |
| "Obesity-induced insulin resistance is the fundamental cause of metabolic syndrome." | ( Lee, BC; Lee, HY; Noh, JW, 2022) |
| "Insulin resistance is associated with atrial remodeling as well as atrial fibrillation (AF)." | ( Chen, K; Chen, S; Guo, L; Li, X; Luo, W; Mei, Q; Qu, X; Yang, X; Zeng, C; Zhou, B, 2022) |
| "Insulin resistance is one of the predominant toxicities for TPHP, but not for DPHP." | ( Chen, H; Duan, X; Sun, C; Sun, H; Sun, X; Yue, J; Zhang, L, 2023) |
| "eGDR, a proxy for insulin resistance, is associated with retinopathy and kidney disease in young adults with T1D." | ( Andersson Franko, M; Lind, M; Linn, W; Ludvigsson, J; Nyström, T; Persson, M; Rathsman, B, 2023) |
| "Mechanistically, insulin resistance is associated with increased serine phosphorylation of the insulin receptor substrate (IRS) mediated by serine/threonine kinases including mTOR and p70S6K." | ( Den Hartogh, DJ; Tsiani, E; Vlavcheski, F, 2023) |
| "Molecularly, insulin resistance is initiated by inflammatory pathways and sustained by intracellular ceramide signaling." | ( Bensussen, A; Roces de Álvarez-Buylla, E; Torres-Magallanes, JA, 2023) |
| "Insulin resistance is a key factor in the development of T2D." | ( Boujraf, S; Chikri, M; Errafii, K, 2023) |
| "Insulin resistance is a common risk factor for metabolic syndrome (MetS), leading to type 2 diabetes mellitus and cardiovascular diseases." | ( Park, S, 2023) |
| "Insulin resistance is independently associated with CAC and is an important risk factor for CVD." | ( Chen, R; Ding, H; Liu, B; Liu, H; Mu, D; Shi, Y; Song, L; Tian, Y; Xu, L; Zhu, J, 2023) |
| "Insulin resistance is associated with metabolic inflexibility, which interferes with the body's ability to switch from free fatty acids to carbohydrate substrates, as well as with the ectopic accumulation of triglycerides in non-adipose tissue, such as that of skeletal muscle, the liver, heart, and pancreas." | ( Ahn, B, 2023) |
| "Insulin resistance is a phenomenon in which the lowering blood glucose capacity of insulin is decreased, which is a feature of type 2 diabetes mellitus." | ( Gao, X; Hong, P; Li, Y; Liu, Y; Yuan, L, 2023) |
| "Obesity and insulin resistance are risk factors for the pathogenesis of type 2 diabetes (T2D)." | ( Ai, W; Chen, Y; Guo, S; Jiang, W; Kim, DM; Pan, Q; Safe, S; Shen, Z; Sun, Y; Yang, W, 2023) |
| "Insulin resistance is associated with the development of metabolic disorders such as cardiovascular and kidney disease, atherosclerosis, stroke, and cancer." | ( Santoleri, D; Titchenell, PM; Uehara, K; Whitlock, AEG, 2023) |
| "Brain insulin resistance is highly emphasized and characterized as an important pathogenic mechanism in the DCD." | ( Bu, T; Bu, X; Ni, Q; Wen, Z; Yang, Y; Zhang, S; Zhang, Y, 2023) |
| "Insulin resistance is associated with a disruption in the normal cyclical pattern of insulin secretion." | ( Alexander, M; Greenway, F; Hepford, SA; Jackson, LK; Lakey, JRT; Lewis, ST; Loveridge, B; Tucker, TR, 2023) |
| "Obesity-induced insulin resistance is considered as the major pathogenic factor in T2DM." | ( Biju, PG; Radhika, A; Sherin, S; Shijina, BN, 2023) |
| "Insulin resistance is a well-established contributor to inflammation; however, the specific association between the triglyceride glucose (TyG) index, a biomarker reflecting insulin resistance, and arthritis remains unexplored." | ( Huang, L; Jiang, D; Jiang, M; La, R; Wu, Q; Xu, W; Yan, Y; Zhou, L, 2023) |
| "Insulin resistance is characterized by ectopic fat accumulation leading to cardiac diastolic dysfunction and nonalcoholic fatty liver disease." | ( de Wit-Verheggen, VHW; Gemmink, A; Haas, J; Hesselink, MKC; Joris, PJ; Liénard, V; Montaigne, D; Nascimento, EBM; Phielix, E; Raiko, J; Schaart, G; Schrauwen, P; Schrauwen-Hinderling, VB; Staels, B; van de Weijer, T; Vanweert, F; Wierts, R; Wildberger, JE, 2023) |
| "Insulin resistance is highly prevalent in patients with diabetes mellitus in Uganda and is associated with periodontitis and low body weight." | ( Buwembo, W; Kaddumukasa, M; Kiryowa, HM; Munabi, IG; Mwaka, ES; Rwenyonyi, CM, 2023) |
| "Insulin resistance is the decreased effectiveness of insulin receptor function during signaling of glucose uptake." | ( Kesari, S; Kouznetsova, VL; Tim, B; Tsigelny, IF, 2023) |
| "Insulin resistance is an important feature of metabolic syndrome and a precursor of type 2 diabetes mellitus (T2DM)." | ( Guo, S; Jiang, W; Yang, W, 2023) |
| "Insulin resistance is a pivotal risk factor for cardiovascular diseases, and the triglyceride-glucose (TyG) index is a well-established surrogate of insulin resistance." | ( Feng, X; Gao, R; Hui, R; Jiang, L; Song, L; Sun, K; Tian, J; Wang, D; Wang, J; Xu, B; Xu, L; Yuan, J; Zhang, C; Zhang, Y; Zhao, W; Zhao, X, 2023) |