An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Reference |
|---|
| "Immediate relief of pain is experienced after the solution of local anaesthetic and steroid has been deposited deep within the fleshy portion of the muscle." | ( Wyant, GM, 1979) |
| "Pain is not an electrical impulse derived from tissue injury but an emotional experience arising when a nervous input is interpreted in the light of experience and emotional context as being 'painful'." | ( Marsden, CD, 1979) |
| "This pain is aggravated by exercise, walking downstairs and sharp bending of the knee." | ( Weiser, HI, 1979) |
| "The pain is elicited by exertional ischaemia." | ( Orava, S; Puranen, J, 1979) |
| "Full sedation of pain is achieved in 30 to 40 p." | ( Farcot, JM; Farny, J; Gauthier-Lafaye, P; Haberer, JP; Laugner, B; Schoeffler, P, 1979) |
| "Thus, pain is a non-osmolar factor capable of elevating AVP in conscious man." | ( Fisher, DA; Kendler, KS; Weitzman, RE, 1978) |
| "Pain is defined as the central perception of senses evoked by peripheral sensors." | ( Grabow, L, 1978) |
| "When the ureteral pain is due to hyperperistalsis the drug has promise in the alleviation of pain." | ( Boyarsky, S; Labay, PC, 1978) |
| "Usually such pains are observed in patients with 2 and more cornary arteries affected by the disease." | ( Buslenko, NS; Fitileva, LM; Zingerman, LS, 1975) |
| "Growing pains is a poorly named, nebulous entity that can be diagnosed only by exclusion." | ( Peterson, HA, 1977) |
| "Growing pains are recurrent limb pains peculiar to children." | ( Calabro, JJ; Holgerson, WB; Repice, MM; Wachtel, AE, 1976) |
| "Pain is a common and feared symptom for patients with incurable cancer." | ( Brescia, FJ; Gray, G; Krasnoff, L; Portenoy, RK; Ryan, M, 1992) |
| "Neuropeptides and pain is discussed in relation to tachykinins and their antagonists, cholecystokinin (CCK) and its antagonists and somatostatin." | ( Duggan, AW, 1992) |
| "Pain is the most frequently reported symptom in the health care industry today." | ( Kodiath, A; Kodiath, MF, 1992) |
| "The origin of the pain is uncertain, although mechanisms related to optic nerve or ocular muscle involvement should be considered." | ( de Stoutz, N; Mermoud, A; Safran, AB, 1992) |
| "Shoulder pain is a common problem in hemiplegia." | ( Joynt, RL, 1992) |
| "Some pains are morphine resistant, especially those due to nerve injury." | ( Twycross, RG; Zylicz, Z, 1991) |
| "Acute pain is easy to diagnose, the cause of pain obvious and the treatment logical, chronic pain has a greater psychological component, is difficult to diagnose and treatment is often empirical." | ( Boey, WK, 1991) |
| "The pain is most frequently the characteristic symptom of osteoarthritis of the wrist, however it may appear without an accident (as a part of destructive and systemic disease, damaging the joints) too." | ( Kubatov, M; Renner, A; Viola, T; Zimmermann, I, 1991) |
| "Anterior knee pain is a frequent musculoskeletal complaint affecting all ages, both sexes, athletes, and nonathletes alike." | ( Beaman, DN; Glover, RA; Janda, D; Wojtys, EM, 1990) |
| "Neurogenic pain is defined as pain due to dysfunction of the peripheral or central nervous system, in the absence of nociceptor (nerve terminal) stimulation by trauma or disease." | ( Bowsher, D, 1991) |
| "In addition, when pain is identified, physicians may be apprehensive about the use of strong analgesic drugs and their side effects, so that pain control is poor." | ( Hillier, R, 1990) |
| "Pain is an understudied problem in geriatric medicine and especially among nursing home residents." | ( Ferrell, BA; Ferrell, BR; Osterweil, D, 1990) |
| "Bone pain is the commonest type of pain in cancer patients." | ( Hanks, GW, 1988) |
| "Pain is an important symptom in many of these patients, but it is often either unrelieved or poorly controlled." | ( Coates, G, 1985) |
| "Pain is one of the most feared consequences of cancer." | ( Foley, KM, 1985) |
| "Pain is a frequent problem following recent traumatic spinal cord injury (SCI)." | ( Cremer, SA; Davidoff, G; Maynard, F, 1989) |
| "Deafferentation pain is known usually to be resistant to both narcotic and non-narcotic analgesics." | ( Ghose, K, 1989) |
| "Pain is a sensory and emotional experience and, as such, is always subjective." | ( Helme, RD, 1987) |
| "Pain is probably the only sensation that can be evoked by stimulation of dentin or dental pulp in man." | ( Matthews, B, 1985) |
| "Pain is not solely a fixed neurophysiologic response to a noxious stimulus but a product of the interaction of many variables such as age, cognitive set, personality, ethnic background, and emotional state." | ( Schechter, NL, 1985) |
| "Chronic pain is refractory to most currently marketed regimens." | ( Gershon, S, 1986) |
| "The pain is blocked and its memory erased so that continued, uninterrupted relief is given." | ( Driscoll, CE, 1987) |
| "Pain is a complex somato-psychic experience, and all pains do not respond equally to opioid analgesics." | ( Twycross, RG, 1988) |
| "Chronic pain is a common feature of well-established MS and is usually associated with a myelopathy." | ( Ebers, GC; Foley, KM; Moulin, DE, 1988) |
| "Pain is commonly the initial symptom in peptic ulcer, but the mechanism is controversial." | ( Texter, EC, 1987) |
| "The subject of pain is intimately related to that of mandibular function." | ( Davidson, RM; Mohl, ND, 1987) |
| "Pain is felt in the muscles and joint ligaments whose biological tolerance has been exceeded; this tolerance varies individually and must be genetically determined." | ( Fry, HJ, 1986) |
| "Growing pain is a poorly named, nebulous entity that can be diagnosed only by exclusion." | ( Peterson, H, 1986) |
| "Pain is the most common initial symptom, present in 57 per cent of the cases, followed by sensory disturbances and motor involvement." | ( Arce, CA; Dohrmann, GJ, 1985) |
| "Drug treatment of pain is largely based on clinical experience." | ( Adriaensen, H; van de Walle, J; Vanmeenen, H, 1981) |
| "Pain is the most relevant symptom for many cancer patients, therefore treatment is of great importance." | ( Zimmermann, M, 1982) |
| "Pain is a phenomenon experienced by all forms of life." | ( Nickles, SL; Pressman, AH, 1984) |
| "Chronic pain is recognized to be the most frequent cause of disability in the United States and many industrialized nations today, and is a major cost to society in both work hours lost and medical expenses." | ( Chapman, CR, 1984) |
| "However, chronic pain is poorly understood and, by definition, poorly managed." | ( Fields, HL; Levine, JD, 1984) |
| "Usually, pain is caused by the excitation of nociceptors or of nociceptive afferent fibers." | ( Zimmermann, M, 1981) |
| "Fever and pain are the most common issues in pediatric patient management." | ( Gladtke, E, 1983) |
| "Pain is traditionally measured in analgesic studies by employing verbal descriptors of intensity, but more recently visual analogues of pain intensity have been used and generally provide more sensitive measures of pain intensity." | ( Wallenstein, SL, 1984) |
| "Chronic pain is distinguished from persistent pain and it is proposed that chronic pain involves addiction to the endogenous opioid system." | ( Portnow, JM, 1984) |
| "Chest pain is thus a common problem of adolescence that produces considerable functional impairment not attributable to serious underlying disease." | ( Goodman, BW; Pantell, RH, 1984) |
| "Since pain is a complex psychophysical phenomenon, algesimetry has a lot of inherent problems which are discussed." | ( Handwerker, HO, 1984) |
| "Pain is also the most important of the 3 health status components in explaining medication usage (P less than 0." | ( Anderson, JJ; Kazis, LE; Meenan, RF, 1983) |
| "Disabling shoulder pain is common in those who engage in athletic activities and there is a wide spectrum of causes." | ( Leach, RE; Schepsis, AA, 1983) |
| "When pain is localized to joints, the patient must be carefully evaluated." | ( Weiner, SR, 1983) |
| "Spontaneous pain is also relieved." | ( Loch, MH; Loch, WE; Reiriz, HM; Wenger, AP, 1983) |
| "Calf pain is a common complaint in the primary care setting." | ( Katerndahl, DA, 1980) |
| "If pain is in the trigeminal nerve distribution, local nerve block procedures may provide additional relief." | ( McCann, CF; Scott, RM; Shapshay, SM; Stoelting, I, 1980) |
| "Learned pain is a distinct entity with its own set of symptoms, diagnostic criteria, and treatment methods." | ( Brena, SF; Chapman, SL, 1981) |
| "Pain is a sensory end-point that can be generated by a number of dissimilar processes." | ( Woolf, CJ, 1994) |
| "Visceral pain is an important component of many clinical pain states." | ( Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K, 1995) |
| "Pain is a well known complication of propofol injection." | ( Khoo, ST; Tham, CS, 1995) |
| "The pain is caused mainly by the vehicle." | ( Frenken, LA; Koene, RA; van Lier, HJ, 1994) |
| "Pain is not usually considered a symptom of chronic relapsing demyelinating polyneuropathy." | ( Brunet, DG; Zochodne, DW, 1994) |
| "Pain is among the most prevalent symptoms experienced by cancer patients." | ( Cherny, NI; Portenoy, RK, 1993) |
| "Pain is one of the most common and feared symptoms associated with cancer." | ( Grossman, SA; Staats, PS, 1994) |
| "Chronic central pain is a frequent complication after spinal cord injury." | ( Andreasen, A; Drewes, AM; Poulsen, LH, 1994) |
| "Cancer pain is prevalent and undertreated despite the availability of therapeutic options that, taken together are highly effective, economical and safe." | ( Patt, RB, 1994) |
| "Tourniquet cuff pain is a significant cause of morbidity following regional anaesthesia of the upper limb." | ( Fell, RH; James, NK; Khoo, CT, 1994) |
| "Pain is an important problem for patients with cancer and is particularly important for elderly patients with cancer and their family care givers." | ( Ahn, C; Ferrell, BA; Ferrell, BR; Tran, K, 1994) |
| "Procedure-related pain is a significant problem for many children receiving cytotoxic chemotherapy." | ( Arnold, M; Betcher, DL; Dose, AM; Goh, TS; Loprinzi, CL; MacKellar, DJ; Miser, AW; Niedringhaus, RD; O'Fallon, JR; Simmons, P, 1994) |
| "When pain is manifested, it appears late during the ischemic event." | ( Sylvén, C, 1993) |
| "Pain is a common and complex problem in the geriatric population." | ( Forman, WB; Roche, RJ, 1994) |
| "Since pain is induced proximal to the peripheral nociceptors, the model can be used to test central analgesic properties of i." | ( Björkman, R; Elam, M, 1993) |
| "Dental pain is usually the first sign and can induce misdiagnosis." | ( Eury, J; Gilain, L; Peynegre, R, 1993) |
| "Why anorectal pain is relieved by sitting in a warm-water bath was investigated in 18 healthy volunteers and 28 patients with painful anorectal disease (18 patients with fissures and 10 with hemorrhoids)." | ( Shafik, A, 1993) |
| "Pain is the symptom that patients want addressed." | ( Schnitzer, TJ, 1993) |
| "Incident pain is a major problem for most patients with cancer pain." | ( Jadad, AR; McQuay, HJ, 1994) |
| "Procedural pain is more common than pain related to disease in the management of paediatric cancer." | ( Cavalletto, B; Cooper, MG; Dalla Pozza, L; Kilham, HA; Stevens, MM, 1994) |
| "Pain is difficult and sometimes frustrating to treat, even though new devices and new approaches have been developed in recent years." | ( Labrecque, G; Vanier, MC, 1995) |
| "Although periobital pain is a frequent finding in patients suffering from cluster headaches, to the authors' knowledge this is the first reported case of orbital inflammation with cluster headache." | ( Acquadro, MA; Chen, VN; Rubin, PA, 1996) |
| "Pain is an important symptom in 75 to 80% of noncancer patients in the last year of life." | ( Burt, R; Butler, RN; Foley, KM; Morris, J; Morrison, RS, 1996) |
| "Leg and/or back pain is associated with the intrathecal use of hyperbaric 5% lignocaine." | ( Aromaa, U; Cozanitis, DA; Salmela, L, 1996) |
| "Pain is an important indicator of stress particularly after surgical operation." | ( Cherng, CH; Ho, ST; Wong, CS, 1995) |
| "Pain is a significant health problem, and there is considerable need for clinical and epidemiological research in this topic." | ( Ejlersen, E; Hamburger, H; Hansen, I; Sabroe, S; Sørensen, HT, 1996) |
| "Long-term pain is a common sequela of thoracotomy, occurring in approximately 50% of patients 2 years after thoracic surgery." | ( Jackson, M; Katz, J; Kavanagh, BP; Sandler, AN, 1996) |
| "If chymopapain is used as a first-line treatment, with surgery reserved for the failures, the long-term outcome is good or excellent in 82%." | ( Bradbury, N; Mulholland, RC; Wilson, LF, 1996) |
| "Pain is common among children infected with HIV and can adversely impact on their lives, and its management should be a component of the general care of these patients." | ( Dragisic, K; Hirschfeld, S; Moss, H; Pizzo, PA; Smith, W, 1996) |
| "When pain is the primary indication, the use of adjuvant analgesics is one strategy that must be evaluated in comparison with other potentially analgesic approaches." | ( Portenoy, RK, 1996) |
| "Chronic pain is a significant public health problem and frustrating for everyone affected by it." | ( Clark, MR; Koenig, TW, 1996) |
| "Pain is normally evoked only by stimuli that are sufficiently intense to activate high-threshold A(delta) and C sensory fibres, which relay the signal to the spinal cord." | ( Doubell, TP; Leslie, T; Neumann, S; Woolf, CJ, 1996) |
| "Moderate to severe pain is a common and early symptom of GBS and requires aggressive treatment." | ( Amireh, R; Feasby, TE; Hagen, N; Hahn, A; Moulin, DE, 1997) |
| "The pain is conventionally controllable with moderate to relatively high doses of intravenous morphine." | ( Slart, R; Sorkin, LS; Yaksh, TL; Yu, AL, 1997) |
| "Neuropathic pain is the most common form of opioid-poorly-responsive pain." | ( Forbes, K; Hanks, GW, 1997) |
| "Many pains are controlled by non-addictive procedures ranging from exercise to a variety of analgesic medications." | ( Merskey, H, 1997) |
| "The pain is relieved by sitting or lying down, not by standing and resting as would be seen in arterial insufficiency-induced claudication." | ( Christensen, VM; Funk, JD; Goldman, SM, 1997) |
| "Pain is a well known complication of propofol injection." | ( Bornscheuer, A; Goldmann, R; Kirchner, E, 1997) |
| "Pain is the main reason prompting patients to consult their physicians." | ( Brasseur, L, 1997) |
| "Pain is the major symptom that leads patients to consult their physicians for the treatment of arthritis; therefore, effective pain control is an important goal in the management of this disorder." | ( Lane, NE, 1997) |
| "Because pain is a biopsychosocial phenomenon, psychological and social assessment are essential along with adequate trials of opioid responsiveness." | ( Krames, ES; Olson, K, 1997) |
| "Pain is the most feared symptom for patients diagnosed with cancer." | ( Ahmedzai, S, 1997) |
| "Pain is the most frequent symptom." | ( De Laat, M; Devulder, J; Dumoulin, K; Ghys, L; Rolly, G, 1997) |
| "Physical pain is a major trigger for changes in many homeostatic systems of the body physiology." | ( Andersson, HI; Kandell-Collén, A; Nilsson, PM, 1997) |
| "Pain is a frequent and distressing complaint in patients with multiple sclerosis (MS) and may present a difficult therapeutic problem." | ( Houtchens, MK; Richert, JR; Rose, JW; Sami, A, 1997) |
| "Breast pain is a common, often distressing problem among women." | ( Rodriguez, JL; Steinbrunn, BS; Zera, RT, 1997) |
| "Although pain is the most feared part of the terminal life of many patients with cancer, the intensity and the quality of the pain is all too often only scantly described." | ( Andrén-Sandberg, A; Grahm, AL, 1997) |
| "Breakthrough pain is usually treated with short-acting oral opioids, most of which provide some relief after 15-20 minutes, with peak effects after 30-45 minutes." | ( Busch, M; Cleary, J; Farrar, JT; Nordbrock, E; Rauck, R, 1998) |
| "Subcalcaneal pain is a common complaint presented to the orthopaedist." | ( Geppert, MJ; Mizel, MS, 1998) |
| "The cause of the pains is uncertain but similar symptoms have been reported in subjects with benign intracranial hypertension and may relate to spinal nerve root pouch distension." | ( Gallagher, AC; Trounce, JQ, 1998) |
| "Daily pain is prevalent among nursing home residents with cancer and is often untreated, particularly among older and minority patients." | ( Bernabei, R; Dunlop, R; Gambassi, G; Gatsonis, C; Landi, F; Lapane, K; Lipsitz, L; Mor, V; Steel, K, 1998) |
| "Malignancy-related pain is of similar frequency in children and adolescents as in adults." | ( Döbig, C; Griessnger, N; Likar, R; Sittl, R; Winter, E, 1998) |
| "Pain is a common feature of interstitial cystitis (IC)." | ( Buffington, CA; Wolfe, SA, 1998) |
| ""Breakthrough pain" is a common clinical term that has not been conclusively defined or described." | ( Ellison, NM; Patt, RB, 1998) |
| "Pain is frequent in the course of cancer and can have negative consequences on patients quality of life." | ( Delfosse, MH; Latour, JF; Ranchere, JY; Saltel, P, 1998) |
| "Overall, pain is one of the most common symptoms associated with cancer and often produces greater anticipatory distress than other features of the disease." | ( Roth, SL; Strumpf, M; Zenz, M, 1998) |
| "Thus, pain is exacerbated by measures inhibiting the immigration of opioid-producing cells or, conversely, analgesia might be conveyed by adhesive interactions that recruit those cells to injured tissue." | ( Cabot, PJ; Machelska, H; Mousa, SA; Stein, C; Zhang, Q, 1998) |
| "Pain is the most disturbing symptom of diabetic peripheral neuropathy." | ( Backonja, M; Beydoun, A; Edwards, KR; Fonseca, V; Garofalo, E; Hes, M; LaMoreaux, L; Schwartz, SL, 1998) |
| "Burn-wound pain is severe, inconsistent and underestimated." | ( Joubert, K, 1998) |
| "Growing pains is an accepted medical term, though the pains are not due to growing." | ( Manners, P, 1999) |
| "Chronic pain is an important cause of suffering, disability and loss of productivity within the community." | ( Chambers, WA; Penny, KI; Purves, AM; Smith, BH; Smith, WC, 1999) |
| "Pain is the most common complaint of patients who see rheumatologists." | ( Moreland, LW; St Clair, EW, 1999) |
| "In a minority the pains are debilitating and there is stiffness in movement." | ( Angastiniotis, M; Aristidou, K; Eracleous, E; Kanakas, A; Pavlides, N; Posporis, T; Yerakaris, M, 1998) |
| "The pain is typically felt deeply and diffusely, has an orthostatic component, and is suppressed by the ischemia test." | ( Blumberg, H; Hoffmann, U; Mohadjer, M; Scheremet, R, 1997) |
| "Pain is one of the most common reasons for patients to seek medical care." | ( Longton, WC; Mazonson, PD; Zagari, MJ, 1996) |
| "Pain is the most common symptom of advanced cancer." | ( Levy, MH, 1999) |
| "Severe pain is common." | ( Ferrucci, L; Fried, LP; Guralnik, JM; Ling, S; Lyles, A; Pahor, M; Penninx, BW; Wan, JY, 1999) |
| "The BK-induced pain is abolished or reduced by acetylsalicylate, thus suggesting that acetylsalicylate-sensitive mediators, such as prostaglandins, are involved in its pathogenesis." | ( Chiariello, L; Crea, F; Gaspardone, A; Gioffré, PA; Pellegrino, A; Tomai, F; Versaci, F, 1999) |
| ""Pain is an incredibly complicated pathophysiologic process, as well as a highly individualized experience," says Dr." | ( Zarbock, SF, 1999) |
| "Pain is unique among sensations in that the perceived intensity increases, or sensitizes, during exposure to a strong stimulus." | ( Cesare, P; Dekker, LV; McNaughton, PA; Parker, PJ; Sardini, A, 1999) |
| "Pain is a key issue with these users; however, they are probably not receiving optimal treatment." | ( Busto, UE; Romach, MK; Sellers, EM; Somer, G; Sproule, BA, 1999) |
| "Chronic pain is disabling, and the adverse effects of morphine are also disabling." | ( Cain, CK; Francis, JM; Lindner, MD; Plone, MA, 1999) |
| "Pain is a multidimensional experience." | ( Pourchet, S; Salamagne, MH, 1999) |
| "Breakthrough pain is defined as the transient exacerbation of pain occurring in a patient with otherwise stable, persistent pain." | ( Simmonds, MA, 1999) |
| "Chronic pain is recognised as an important problem in the community but our understanding of the epidemiology of chronic pain remains limited." | ( Chambers, WA; Elliott, AM; Penny, KI; Smith, BH; Smith, WC, 1999) |
| "Chronic pain is a major problem in the community and certain groups within the population are more likely to have chronic pain." | ( Chambers, WA; Elliott, AM; Penny, KI; Smith, BH; Smith, WC, 1999) |
| "The neuropathic pain is specific to inflammation of the nerve because it was absent in animals with the experimental myositis and in those receiving sham-treatment." | ( Bennett, GJ; Eliav, E; Herzberg, U; Ruda, MA, 1999) |
| "When pain is relieved inadequately by opioid analgesics given in a dose that causes intolerable side effects despite routine measures to control them, treatment with the same opioid by an alternative route or with an alternative opioid administered by the same route should be considered." | ( Mercadante, S, 1999) |
| "Persistent pain is the most debilitating sequela and it occurs in at least 15% of individuals over 50 years of age." | ( Gnann, JW; Whitley, RJ, 1999) |
| "Knee and leg pain are the most common symptoms, and physicians working in orthopaedics and traumatology are the first to be consulted." | ( Katthagen, BD; Sistermann, R, 2000) |
| "Significant pain is common but is often undertreated despite available medications and technology." | ( Clasen, ME; Jonas, AP; Whitecar, PS, 2000) |
| "Neuropathic pain is often associated with the appearance of pain in regions not related to the injured nerve." | ( Bian, D; Gardell, LR; Ibrahim, M; Lai, J; Malan, TP; Ossipov, MH; Porreca, F, 2000) |
| "Bone cancer pain is common among cancer patients and can have a devastating effect on their quality of life." | ( Clohisy, DR; Honore, P; Luger, NM; Mach, DB; Mantyh, PW; O'keefe, PF; Ramnaraine, ML; Rogers, SD; Sabino, MA; Schwei, MJ, 2000) |
| "Pain is a ubiquitous component of pediatric illness and injury." | ( Schechter, NL; Zempsky, WT, 2000) |
| "Pain is a disruptive influence on infants in the NICU." | ( Franck, LS; Gibbins, S; Stevens, B, 2000) |
| "Generally, pain is not well controlled in hospitals and steps need to be taken to make pain control more effective." | ( Ravenscroft, P; Schneider, J, 2000) |
| "Neuropathic pain is associated with abnormal tactile and thermal responses that may be extraterritorial to the injured nerve." | ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F, 2000) |
| "Pain is an important symptom of acute damage and chronic inflammatory diseases such as rheumatoid arthritis." | ( Schaible, HG; Vanegas, H, 2000) |
| "Pain is the primary problem targeted for control using the World Health Organization's (WHO) analgesic ladder." | ( Hamann, SR; McDonnell, FJ; Sloan, JW, 2000) |
| "Pain is a subjective phenomenon that we can measure only by indirect methods." | ( Okifuji, A; Turk, DC, 2000) |
| "Neuropathic pain is increased, and the mice show a complete absence of the pharmacological analgesic effects of NPY." | ( Blakeman, KH; Ernfors, P; Hao, JX; Hassani, H; Lucas, G; Naveilhan, P; Thorén, P; Wiesenfeld-Hallin, Z; Xu, XJ, 2001) |
| "Pain is prevalent and undertreated in nursing home residents, despite the existing wide array of effective pharmacological and nonpharmacological treatment modalities." | ( Hanlon, JT; Weiner, DK, 2001) |
| "Perineal pain is one of the most common causes of maternal morbidity in the early puerperium." | ( Alfirevic, Z; Corkill, A; Lavender, T; Walkinshaw, SA, 2001) |
| "Pain is often inadequately treated, although it can be controlled simply in the majority of cases." | ( Bertolaccini, L; Olivero, G, 2000) |
| "Pain is the primary problem targeted for control using the World Health Organization's (WHO) analgesic ladder." | ( Hamann, SR; McDonnell, FJ; Sloan, JW, 2001) |
| "Osteoarthritis pain is of multifactorial origin, and inflammatory mechanisms play only a partial role." | ( Pavelka, K, 2000) |
| "Pain is a significant problem in many patients with genitourinary malignancy at all stages of disease." | ( Harrison, P, 2001) |
| "Pain is a comprehensive phenomenon which concerns not only physiology, biochemistry and molecular biology but also music, art, religion, philosophy and everyday life." | ( Währborg, P, 2001) |
| "(Breakthrough pain is a transient increase in pain in a patient who has stable, persistent pain treated with opioids." | ( de Wit, R; Enting, RH; Lieverse, PJ; Smitt, PA; van der Rijt, CC; Wilms, EB, 2001) |
| "Although knee pain is the impetus for imaging, ganglion cysts are often incidental findings." | ( Ellen, MI; Gilhool, JJ; Rogers, DP, 2001) |
| "Joint pain is a very common complaint among elderly persons and may lead to functional disability." | ( Al Snih, S; Goodwin, JS; Markides, KS; Ray, L, 2001) |
| "Pinprick pain is mediated primarily by capsaicin-insensitive A-fibre nociceptors, which include high-threshold mechanoreceptors and type I mechano-heat nociceptors." | ( Fuchs, PN; Magerl, W; Meyer, RA; Treede, RD, 2001) |
| "Chronic pain is a widespread, difficult problem facing clinicians." | ( Adams, NJ; Fleming, MF; Mundt, MP; Plane, MB; Saunders, LA; Stauffacher, EA, 2001) |
| "Management of pain is a great problem in patients with cancer." | ( Kuraishi, Y, 2001) |
| "Undertreatment of pain is a persistent clinical problem for patients with cancer." | ( Dohi, S, 2001) |
| "When the cancer pain is classified as neuropathic pain, we should use antidepressants, anticonvulsants, anxiolytics, or/and anti-arrhythmic drug." | ( Morimoto, M, 2001) |
| "Disabling chronic pain is especially devastating among working population and, in many cases, it does not respond to conventional therapies." | ( Arias i Gassol, A; Cerdà Gabaroi, D; Collado Cruz, A; Muñoz-Gómez, J; Torres i Mata, X; Valdés Miyar, M; Vilarrasa, R, 2001) |
| "Pain is the most prominent symptom and clinical finding in osteoarthritis (OA)." | ( Lipman, AG, 2001) |
| "Pain is a significant problem for community-dwelling elders and for elderly persons in residential facilities." | ( Miaskowski, C, 2000) |
| "Pain is a complex phenomenon with a strong affective-emotional component in addition to a sensory-discriminative one." | ( Cruccu, G; Di Legge, S; Di Piero, V; Ferracuti, S; Lenzi, GL; Pantano, P; Sabatini, U; Tombari, D, 2001) |
| "The pain is characterized by a burning or stinging sensation similar to neuropathic pain sensations." | ( Andersen, J; Ehrnrooth, E; Grau, C; Zachariae, R, 2001) |
| "Neuropathic pain is a debilitating chronic syndrome that often arises from injuries to peripheral nerves." | ( Bian, D; Gold, MS; Hunter, JC; Kim, CS; Lai, J; Ossipov, MH; Porreca, F, 2002) |
| "Pain is defined as an unpleasant experience-it is subjective and achieving pain relief is achieving a change in the patient's experience." | ( Lickiss, JN, 2001) |
| "Pain is undertreated in all parts of the world." | ( Heit, HA, 2001) |
| "The 'patient' with pain is a complex individual and the 'drug' is not the same in effect to every patient, regardless of being an opioid analgesic." | ( Mather, LE, 2001) |
| "The management of pain is still a critical issue in the care of patients both with cancer and non-cancer pain." | ( Huang, Y, 2001) |
| "Chronic non-cancer pain is a complex biopsychosocial phenomenon; as such it is unlikely that any one treatment modality will achieve relief." | ( Goucke, CR, 2001) |
| "The assessment of pain is difficult and should include both physiological and behavioural parameters." | ( Schollin, J, 2001) |
| "Intraoperative pain is the main topic that requires improvement." | ( Bech, K; Callesen, T; Kehlet, H, 2001) |
| "Pain is common but is often undertreated in critically ill patients." | ( McCaffery, M; Pasero, C, 2001) |
| "Since pain is an important symptom in arthritis, useful behavioral indices for pain in experimental arthritis animal models are important tools for investigative work on arthritis." | ( Chung, JM; Grady, JJ; Kim, CH; Koo, ST; Lyu, Y; Yu, YC, 2002) |
| "Pain is a feature of many cancers, particularly in the advanced stages at which the palliative care approach to symptom control achieves the best outcomes." | ( Gourlay, GK, 2001) |
| "Pain is an unpleasant sensory and emotional experience usually triggered by stimulation of peripheral nerves and often associated with actual or potential tissue damage." | ( Clare, S; Gati, JS; Matthews, PM; Menon, RS; Ploghaus, A; Smith, S; Tracey, I, 2002) |
| "Although continuous pain is by far less severe than intermittent pain, the treatment is, in both cases, essentially pharmacological relying basically on opioids." | ( Latarjet, J, 2002) |
| "Anticipation of pain is a complex state that may influence the perception of subsequent noxious stimuli." | ( Baraldi, P; Facchin, P; Maieron, M; Nichelli, P; Pagnoni, G; Porro, CA; Serafini, M, 2002) |
| "Pain is often reported as a symptom of CI and it is defined as a subjective experience similar to many other symptoms of CI, making its objectification difficult." | ( Bushnell, MC; Duncan, GH; Rainville, P, 2001) |
| "Cancer pain is a significant problem despite the advent of the World Health Organization's cancer pain guidelines, the US government's cancer pain guidelines, and the Joint Commission's mandate for hospital pain evaluation and treatment." | ( Lordon, SP, 2002) |
| "Pain is a common feature of spasticity and muscle spasms and the reasons for this are discussed in this article." | ( Kadies, M; Ward, AB, 2002) |
| "Loin pain is precipitated in the case of the former and urinary retention in the latter case after consuming alcohol." | ( Arun, CP, 2002) |
| "Fear of block pain is diminished after experiencing the blocking procedure." | ( Koscielniak-Nielsen, ZJ; Rassmussen, H; Rotbøll-Nielsen, P, 2002) |
| "Pain is the major complaint of patients who choose acupuncture treatment." | ( Attele, AS; Dey, L; Guan, X; Lynch, JP; Yuan, CS, 2002) |
| "Pain is very common throughout the world and is an increasing problem in the ageing population." | ( Moore, RA, 2002) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | ( , 2002) |
| "capsaicin-induced pain is acceptable for pharmacological profiling of novel anti-nociceptive agents, with limited number of subjects." | ( Growcott, J; Hughes, A; Macleod, A; Thomas, I, 2002) |
| "Pain is the most feared symptom for patients with advanced cancer." | ( Regaard, A, 2000) |
| "This pain is of short duration and after 3 minutes, the level of pain is independent of the type of device which has been inserted." | ( Goldstuck, ND, 1981) |
| "Pain is associated with myriad medical conditions and affects millions of Americans." | ( Argoff, CE, 2002) |
| "Pain is unnecessary." | ( Li, JM, 2002) |
| "Pain is the cancer related event that is most disruptive to the cancer patient's quality of life." | ( Clohisy, DR; Honore, P; Keyser, CP; Luger, NM; Mach, DB; Mantyh, PW; Pomonis, JD; Rathbun, M; Sabino, MAC; Schwei, MJ; Yaksh, TL, 2002) |
| "Burn-induced pain is often inadequately managed and its mechanisms, both peripheral and central, are poorly understood." | ( Junger, H; Moore, AC; Sorkin, LS, 2002) |
| "Pain is a multi-dimensional process involving the physical, emotional and perceptual integration of noxious information." | ( Blackburn-Munro, G; Blackburn-Munro, R, 2003) |
| "Indeed, chronic pain is often inadequately controlled in patients with cancer and in those with non-cancer chronic pain." | ( Nicholson, B, 2003) |
| "Chronic noncancer pain is common in Canadian adults and has a major social and economic impact." | ( Clark, AJ; Morley-Forster, PK; Moulin, DE; Speechley, M, 2002) |
| "Bone cancer pain is very common, and patients with this type of pain may be difficult to treat." | ( Clohisy, DR; Mantyh, PW, 2003) |
| "Delirium and pain are common following hip fracture." | ( Gilbert, M; Koval, KJ; Magaziner, J; McLaughlin, MA; Morrison, RS; Orosz, G; Siu, AL; Strauss, E, 2003) |
| "Short-lasting pain is induced by gaseous CO(2), while long-lasting pain is induced by a stream of dry air." | ( Hummel, T; Kobal, G; Lötsch, J; Marchl, R; Mohammadian, P, 2003) |
| "Pain is associated with negative affect such as anxiety and depression." | ( Li, W; Neugebauer, V, 2003) |
| "Treating this pain is often difficult, particularly in elderly patients, owing to iatrogenic effects and to interactions with the pre-existing diseases and treatments frequently present in this age group." | ( Chiquet, C; Gain, P; Maugery, J; Michaud, P; Navez, ML; Pascal, J; Thuret, G, 2003) |
| "Bone pain is a common side effect of treatment with filgrastim." | ( Glaspy, J; Green, MD; Hackett, J; Holmes, FA; Kubista, E; Neumann, T, 2003) |
| "Pain is one of the most common reasons for seeking medical attention, and neuropathic pain is among the most common types of pain." | ( Backonja, M; Glanzman, RL, 2003) |
| "Chronic pain is a common problem affecting about half of the general population." | ( Chambers, WA; Elliott, AM; Haetzman, M; Hannaford, P; Smith, BH, 2003) |
| "Chronic severe pain is prevalent among patients in substance abuse treatment, especially MMTP patients." | ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003) |
| "Control of chronic pain is a major health problem." | ( Cheng, JT; Lee, CT; Lin, CR; Lin, MW; Tai, MH; Tan, PH; Yang, LC; You, HL, 2003) |
| "The sense of pain is an important defense mechanism that has evolved in many species, including ours." | ( Stulhofer, M, 2002) |
| "Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain." | ( Aşik, I; Gülay, I; Tulunay, M; Yörükoğlu, D, 2003) |
| "Neuropathic pain is a significant clinical problem." | ( Abdi, S; Borsook, D; DiLorenzo, L; Feroz, N; Kobierski, LA, 2003) |
| "Pain is more than a sensation; it is influenced by emotional, cognitive, and psychosocial factors." | ( Leo, RJ; Pristach, CA; Streltzer, J, 2003) |
| "Abdominal pain is an important component of vaso-occlusive painful crisis and may mimic diseases such as acute appendicitis and cholecystitis." | ( Ahmed, S; Kimpo, M; Mattana, J; Russo, L; Siddiqui, AK; Siddiqui, RK, 2003) |
| "Chronic pain is highly prevalent among older people with arthritis, with depression as its major outcome." | ( Moore, C; Palencia, I; Tak, S; Tsai, PF, 2003) |
| "Because pain is the hallmark symptom of OM, the authors sought to determine whether a simple measure of patient-reported pain was correlated with objective, physician-assessed measures of OM." | ( Cella, D; Fuchs, H; Giles, F; Hurd, D; Martin, PJ; Miller, C; Pulliam, J; Sonis, ST; Wingard, JR, 2003) |
| "Pain is the most common and feared symptom for patients, especially those with cancer." | ( Altunay, H; Hasirci, V; Sendil-Keskin, D; Wise, DL, 2003) |
| "Muscle pain is a major clinical problem but the underlying mechanisms and its pharmacological modulation need further investigation." | ( Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Schulte, H; Segerdahl, M; Sollevi, A, 2003) |
| "Chronic pain is a subjective experience and has not only physical, but also psychological and social dimensions." | ( Benetka, G; Kozek-Langenecker, SA; Kress, HG; Langer, G; Sator-Katzenschlager, SM; Schiesser, AW, 2003) |
| "Biliary pain is commonly reported in household surveys with the presumed cause being gallstones." | ( Shaffer, E, 2003) |
| "Instead, referred pain is most likely a consequence of misinterpretation of the origin of input from the stimulated focal pain area, due to excitation of neurones somewhere along the neuroaxis with projected fields in the referred pain area." | ( Hansson, P; Kosek, E, 2003) |
| "Joint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA." | ( Bianchi, M; Broggini, M, 2003) |
| "Chronic pain is debilitating and can greatly decrease quality of life, not just due to the pain per se, but also because of the depression that can often ensue." | ( Assis, TS; Currie, AJ; Kennedy, C; Rowan, EG, 2003) |
| "Pain is common in these patients." | ( Kowalski, MO; Petrone, S; Seaman, JJ; Small, EJ; Smith, MR, 2003) |
| "Chronic pain is often difficult to treat effectively." | ( Fink, DJ; Glorioso, J; Mata, M, 2003) |
| "Pain is a common symptom at the end of life." | ( Moynihan, TJ, 2003) |
| "Pain is a multidimensional conscious experience including sensory and negative affective components." | ( Minami, M; Nakagawa, T; Satoh, M; Tanimoto, S; Yamauchi, Y, 2003) |
| "Although pain is a cardinal feature of pancreatitis, its pathogenesis is poorly understood and treatment remains difficult." | ( He, ZJ; Micci, MA; Pasricha, PJ; Shenoy, M; Toma, H; Winston, JH; Xiao, SY; Zou, L, 2003) |
| "Pain is a protective mechanism for the body; it occurs whenever any tissues are being damaged, and it causes the individual to react to remove the pain stimulus." | ( Becker, DE, 1996) |
| "Pain is among the most common complaints for which people seek medical care; yet pain is also among the most undertreated patient complaints." | ( Heit, HA, 2003) |
| "Pain is a unique class of sensory experience from the perspective of salience." | ( Davis, KD; Downar, J; Mikulis, DJ, 2003) |
| "Pain is a significant problem in more than 50% of HD patients and is not being effectively managed." | ( Davison, SN, 2003) |
| "Chronic malignant pain is experienced by as many as 80% of patients with cancer." | ( Herdon, CM, 2003) |
| "Because pain is a highly common presenting complaint in the ED, EPs are pivotal players in these controversies." | ( Fishman, S; Papazian, J; Rose, JS; Wilsey, B, 2004) |
| "Inflammatory pain is caused by sensitization of peripheral and central nociceptive neurons." | ( Bär, KJ; Ebersberger, A; Natura, G; Schaible, HG; Telleria-Diaz, A; Teschner, P; Vasquez, E; Vogel, R, 2004) |
| "The induction of pain is also a reliable, measurable phenomenon in animals receiving continuous delivery of opioid." | ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Vanderah, TW, 2001) |
| "Pain is an important but understudied and often overlooked aspect of emergency medical care." | ( Leffler, S; McIntosh, SE, 2004) |
| "Pain is a common symptom in advanced disease." | ( Hall, EJ; Sykes, NP, 2004) |
| "This pain is unpredictable and produces fear and anxiety in patients and family members." | ( Ghooi, RB; Ghooi, SR, 2003) |
| "Pain is a complex problem, for both those who are enduring it and those trying to relieve it." | ( Spencer, M, 2003) |
| "Pain is a common experience of mankind." | ( Brunsch, H; Kasper, SM; Radbruch, L; Sabatowski, R; Schäfer, D, 2004) |
| "Breakthrough pain is normally severe in intensity and has a rapid onset." | ( Bianchi, M; Casuccio, A; Ferrera, P; Mercadante, S; Villari, P, 2004) |
| "Chronic pain is frequently associated with profound alterations of neuronal systems involved in pain processing and should be considered as a real disease state of the nervous system." | ( Braz, J; Cesselin, F; Hamon, M; Meunier, A; Pohl, M, 2004) |
| "Deep muscle pain is often associated with sensory changes in the corresponding dermatome." | ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004) |
| "Opioid therapy for pain is the subject of numerous randomized clinical trials." | ( Chevlen, E, 2004) |
| "Pain is a common reason to attend hospital but it is often inadequately managed." | ( Butcher, D, 2004) |
| "Pain is probably one of the most common cancer symptoms." | ( Mucksavage, JJ; Slavin, KV; Tesoro, EP, 2004) |
| "Geriatric pain is a significant problem in health care, because of multiple disease processes in this aged population their population will increase." | ( Ozyalçin, NS, 2004) |
| "Pain is commonplace in newborn infants." | ( Katz, J; Taddio, A, 2004) |
| "Chronic pain is often complicated by a variety of psychiatric conditions that make it difficult to engage and treat patients." | ( Clark, MR; Treisman, GJ, 2004) |
| "Pain is an unpleasant sensation." | ( Sudhakar, HH; Venkatesh, D, 2003) |
| "That facial pain is associated with neuroplastic changes within the somatic cortical representation of the hand suggests a pain-related topographic cortical reorganisation." | ( Aglioti, SM; Fiaschi, A; Moretto, G; Nicolato, A; Rosso, T; Tinazzi, M; Valeriani, M, 2004) |
| "Pain is frequently encountered in outpatient oncology practice and its management often is inadequate." | ( Chandran, N; Koshy, RC; Kuriakose, R; Mathew, A, 2004) |
| "Neuropathic pain is a prominent feature of CRPS I, and is often refractory to treatment." | ( Kessels, AH; Stomp-van den Berg, SG; van de Vusse, AC; Weber, WE, 2004) |
| "Pain is a common problem in both adults and children with Guillain-Barré Syndrome (GBS)." | ( Boukhris, S; Kabore, R; Lacoste, M; Mabrouk, T; Magy, L; Vallat, JM, 2004) |
| "Cancer pain is a major problem for cancer patients, as about 80 percent patients with advanced cancer declare pain as their main symptom." | ( Skorupskiene, D, 2004) |
| "Visceral pain is one of the most common forms of pain which is poorly understood." | ( Hosseini, AR; Khansefid, N; Sabetkasaie, M; Sadat Ladgevardi, MA; Vala, S, 2004) |
| "Bone pain is a frequent complication of metastatic bone disease, with severe consequences for patient mobility and quality of life." | ( Body, JJ; Heidenreich, A; Ohlmann, C, 2004) |
| "Breakthrough pain is a transitory flare of pain superimposed on an otherwise stable pain pattern in patients treated with opioids." | ( Casuccio, A; Ferrera, P; Mercadante, S; Villari, P, 2004) |
| "Persistent pain is present to some degree throughout the day and primarily is controlled with around-the-clock medication." | ( Palos, G; Rhiner, M; Termini, M, 2004) |
| "Muscle pain is often accompanied by a feeling of muscle fatigue and weakness." | ( Bach, FW; Fuglsang-Frederiksen, A; Jensen, TS; Kasch, H; Qerama, E, 2005) |
| "Pain is one of the presenting symptoms in acute neuroborreliosis." | ( Berthele, A; Tölle, TR, 2004) |
| "Heel pain is one of the most common presenting complaints to the foot and ankle specialist." | ( Burns, PR; Lowery, C; Scanlan, RL; Zgonis, T, 2005) |
| "Long-standing groin pain is a persistent problem that is commonly difficult to rehabilitate." | ( Bennell, KL; Brukner, P; Coburn, P; Cowan, SM; Crossley, KM; Hodges, PW; Schache, AG, 2004) |
| "Neuropathic pain is one of the important microvascular complications of diabetes." | ( Anjaneyulu, M; Chopra, K, 2004) |
| "Because itch and pain are carried by small nerve fibers, abnormal function of these fibers could be an explanation for such phenomena." | ( Chan, YH; Goh, CL; Lee, SS; Yosipovitch, G, 2004) |
| "Itch and pain are common presentations in keloids and are associated with abnormalities in small nerve fiber function, suggesting a small nerve fiber neuropathy." | ( Chan, YH; Goh, CL; Lee, SS; Yosipovitch, G, 2004) |
| "Breast pain is a common symptom in patients attending breast clinics." | ( Gateley, C; Goyal, A; Kubista, E; Leinster, S; Maddox, PR; Mansel, RE; Preece, P; von Fournier, D, 2004) |
| "In elderly persons, pain is a common problem, and analgesic medicines are among the most frequently used drugs." | ( Hartikainen, SA; Louhivuori-Laako, KA; Mäntyselkä, PT; Sulkava, RO, 2005) |
| "Bone cancer pain is usually progressive as the disease advances, and is particularly difficult to treat." | ( Clohisy, DR; Mantyh, PW, 2004) |
| "Cancer-induced bone pain is a major clinical problem for which current treatments lack full efficacy." | ( Dickenson, AH; Donovan-Rodriguez, T; Urch, CE, 2005) |
| "Pain is a determining factor in patient acceptability of outpatient hysteroscopy and is a likely reason for some women to opt to have a hysteroscopy under general anesthesia." | ( Brown, V; Dass, M; Jivraj, S; Panikkar, J, 2004) |
| "Acute pain is a common presentation associated with opioid seeking behaviour." | ( Hulse, GK; Khong, E; Sim, MG, 2004) |
| "Neuropathic pain is a syndrome that affects around 1% of population." | ( Espinoza-Raya, J; Granados-Soto, V; Medina-Santillán, R; Morales-Franco, G; Reyes-García, G, 2004) |
| "Chronic non-cancer pain is a common problem that is often accompanied by psychiatric comorbidity and disability." | ( Bryant, ME; Chelminski, PR; DeWalt, DA; Felix, KM; Ives, TJ; Malone, RM; Miller, TM; Perhac, JS; Pignone, MP; Prakken, SD, 2005) |
| "Leg pain is a common symptom in dialysis patients." | ( Dudler, J; Lobrinus, JA; Revaz, S; So, AK; Theumann, N, 2005) |
| "Evaluation of pain is subjective, and the severity of pain experienced in the control, vehicle-treated eyes was low." | ( Price, FW; Price, MO, 2004) |
| "Orgasmic pain is an infrequently reported but distressing problem for the patients who experience it." | ( Barnas, J; Guhring, P; Mulhall, JP; Parker, M, 2005) |
| "Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research." | ( Caterina, M; Gu, J; MacDermott, AB; Malmberg, A; Neugebauer, V; Yoshimura, M; Zhuo, M, 2005) |
| "Chronic pain is known to affect and to be affected by neuroendocrine and immune mechanisms." | ( Aloisi, AM; Ceccarelli, I; Ietta, F; Lodi, L; Pari, G; Paulesu, L; Vecchi, I, 2005) |
| "Anterior knee pain is one of the most common orthopedic complaints affecting the knee." | ( Horton, P; Propps, M; Ratner, J; Smith, SS; Watson, CJ; Zeigler, DL, 2005) |
| "Injection pain is a well-known adverse effect of propofol which distresses patients." | ( Fujii, Y; Nakayama, M, 2005) |
| "Pain is commonly associated with inflammation." | ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "Pain is intimately linked with action systems that are involved in observational learning and imitation." | ( Aglioti, SM; Avenanti, A; Bueti, D; Galati, G, 2005) |
| "However, chronic pain is associated with physiological and psychosocial complexities that may also explain the results." | ( Henry, ML; Moseley, GL; Sim, DF; Souvlis, T, 2005) |
| "Indeed, phasic pain is often associated with differential or opposing effects to tonic pain in behavioral, lesion, and pharmacological studies." | ( Dolan, RJ; Driver, J; Kalisch, R; Koltzenburg, M; Seymour, B; Stephan, KE; Wiech, K, 2005) |
| "Chronic pain is associated with motor dysfunctions, and stimulation of the motor cortex has been shown to alleviate chronic pain." | ( Polácek, H; Stancák, A; Vrána, J, 2005) |
| "Pain is a cardinal symptom in 70 % of cancer patients." | ( Harzmann, R; Weckermann, D, 2005) |
| "Chronic pain is a frequent cause of suffering and disability that negatively affects patients' quality of life." | ( Calleson, D; Carey, T; Chen, I; Cykert, S; Faselis, C; Genao, I; Kurz, J; Mechaber, AJ; Menon, M; O'Rorke, J; Panda, M; Pasanen, M; Rosenberg, E; Staton, LJ; Wood, J, 2005) |
| "Formalin-induced pain is reduced in sigma-1 (sigma1) receptor knockout mice; therefore, we hypothesized that haloperidol and its metabolites I and II, which have affinity for sigma1 receptors, may modulate formalin-induced pain." | ( Baeyens, JM; Cendán, CM; Portillo-Salido, E; Pujalte, JM, 2005) |
| "Neuropathic pain is a neuropsychiatric condition in which pain is initiated or caused by a primary lesion or dysfunction in the nervous system." | ( Hainline, B, 2005) |
| "Neuropathic pain is characterised by hyperexcitability within nociceptive pathways that manifests behaviourally as allodynia and hyperalgesia and remains difficult to treat with standard analgesics." | ( Blackburn-Munro, G; Nielsen, AN; Pedersen, LH, 2005) |
| "Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, allodynia and hyperalgesia." | ( Castañé, A; Célérier, E; Ledent, C; Maldonado, R; Martín, M; Parmentier, M; Valverde, O, 2006) |
| "Chronic pain is common, and many people suffer from chronic pain conditions involving deep craniofacial tissues such as temporomandibular disorders or fibromyalgia." | ( Cairns, BE; Hu, JW; Lam, DK; Sessle, BJ, 2005) |
| "Pain is still an actual problem in dentistry, and a usage of anaesthetics can be still limited, so new ways of caries treatment are still being searched in order to ease this process both to a patient and a doctor." | ( Balciuniene, I; Juskiene, I; Sabalaite, R, 2005) |
| "Cancer pain is a significant clinical problem because it is the first symptom of disease in 20% to 50% of all cancer patients, and 75% to 90% of patients with advanced or terminal cancer must cope with chronic pain syndromes related to failed treatment and/or tumor progression." | ( Ghilardi, JR; Halvorson, KG; Kubota, K; Lindsay, TH; Mantyh, PW; Sevcik, MA, 2005) |
| "The injection pain is less at the brachial region than the wrist or the hand." | ( Hoka, S; Inamura, M; Isono, M; Kanai, A; Kosaka, Y; Nakano, T; Nomiyama, S; Okamoto, H; Ozawa, A; Ueno, T, 2005) |
| "However, if pain is unmanageable in the outpatient department, we believe that options include hospital admission, using the contained method of application or, in the worst case scenario, cessation of treatment." | ( Budding, T; Oskam, J; Steenvoorde, P, 2005) |
| "Relief of chronic pain is an important clinical problem requiring special care and approaches." | ( Hasirci, V; Keskin, DS; Wise, DL, 2004) |
| "Jaw pain is present in about 19% of patients with RA and OA, and is primarily a marker for a general pain increase and symptom sensitivity problem." | ( Katz, RS; Michaud, K; Wolfe, F, 2005) |
| "Familial rectal pain is a very rare entity that must always be considered as a possible aetiology of any life-threatening event in an infant because of the availability of a very effective treatment." | ( Arbuès, AS; Bednarek, N; Morville, P; Motte, J; Plouin, P; Sabouraud, P, 2005) |
| "Bone cancer pain is mostly associated with an inflammatory response dominated by local activation of osteoclasts and by astrogliosis in the spinal cord." | ( Beitz, A; Eikmeier, L; Fike, JR; Jasmin, L; Ohara, PT; Tien, DA; Vit, JP; Wilcox, GL, 2006) |
| "Chronic pain is common in patients with spinal cord injury (SCI)." | ( Chiodo, A, 2005) |
| "Musculoskeletal pain is a major clinical problem." | ( Grass, S; Graven-Nielsen, T; Schulte, H; Segerdahl, M, 2006) |
| "Pain is one of the most common reasons patients seek dental treatment." | ( Abbott, PV; Hargreaves, K, 2005) |
| "Neuropathic pain is a common and potentially treatable cause of considerable lifelong morbidity." | ( Baillie, JK; Power, I, 2006) |
| "Chronic pain is a major health problem in the United States affecting 50 to 75 million Americans." | ( Ineck, JR; Rule, AM; Wilken, M, 2005) |
| "Breakthrough pain is a transient increase in pain intensity over background pain." | ( Ribeiro, MD; Zeppetella, G, 2006) |
| "Muscle pain is different from cutaneous pain in its characteristics as well as conducting fibers." | ( Ko, SW; Petrovic, MJ; Sluka, KA; Vadakkan, KI; Wang, H; Zastepa, E; Zhuo, M, 2006) |
| "Neuropathic pain is a condition affecting a significant proportion of the world's population." | ( López-Trigo, J; Sancho Rieger, J, 2006) |
| "Pain is among the most frequently reported, bothersome, and disabling symptoms described by patients with osteoarthritis, rheumatoid arthritis, fibromyalgia, and other musculoskeletal conditions." | ( Bathon, J; Bingham, CO; Edwards, RR; Haythornthwaite, JA, 2006) |
| "Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention." | ( Brandt, KD; Buckwalter, KA; Mazzuca, SA, 2006) |
| "Chronic pain is a chronic disease and, like diabetes or hypertension, requires chronic concessions and lifestyle modifications." | ( Bloodworth, D, 2006) |
| "Currently, pain is inadequately managed." | ( Bennett, KC; Dunlop, RJ, 2006) |
| "Inflammatory pain is linked to sensitization of sensory proteins at the nociceptive endings whereas pain originating from nerve damage (neuropathic pain) has been linked to changes in axonal ion channels producing ectopic discharge in nociceptors as a source of pain." | ( Schaible, HG; Schmelz, M; Tegeder, I, 2006) |
| "Pain is an unpleasant sensory experience commonly produced by damage to bodily tissues and it is one of the most significant public health problems, because 21." | ( Al Malyan, M; Ashammakhi, N; Becchi, C; Boncinelli, S; Chiellini, F; Nikkola, L; Viitanen, P, 2006) |
| "Both, pruritus and pain are aversive, but clearly distinct sensations originating in the peripheral and central nervous system." | ( Schmelz, M; Ständer, S, 2006) |
| "Pain is the most debilitating symptom in osteoarthritis of the knee (OAK)." | ( Bjordal, JM; Klovning, A; Ljunggren, AE; Slørdal, L, 2007) |
| "Pain is a major quality issue." | ( Degenholtz, H; Fischberg, D; Litke, A; Maroney-Galin, C; Meier, DE; Moore, C; Morrison, RS; Siu, AL, 2006) |
| "When the pain is intractable and the eye has very poor vision and is disfigured, surgical removal of the eye has traditionally been the definitive treatment of choice." | ( Merbs, SL, 2006) |
| "Given that neck pain is very common in primary headache disorders, this convergent excitation may play a role in pain referral from cervical structures." | ( Akerman, S; Bergerot, A; Classey, JD; Goadsby, PJ; Holland, PR; Knight, YE; Lasalandra, MP; Le Doaré, K, 2006) |
| "Although pain is a common patient complaint in emergency departments, many people receive no analgesia." | ( Costello, M; Grammas, M; Heins, A; Heins, JK; Huang, K; Mishra, S, 2006) |
| "Pain is not the most frequent symptom in cancer patients, but it is considered the most serious and threatening symptom." | ( Eriksen, J; Lundorff, LE; Sjøgren, P, 2006) |
| "Neuropathic pain is associated with a number of disease states of diverse aetiology that can share common pathophysiological mechanisms." | ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "Pain is a complicated phenomenon." | ( Collins, JJ; McCulloch, R, 2006) |
| "Neuropathic pain is often a consequence of nerve injury through surgery, bone compression, cancer, diabetes or infection." | ( Inoue, K, 2006) |
| "Pain is usually accompanied by limited mobility of the shoulder and sometimes by swelling of the hand and wrist." | ( Zyluk, A; Zyluk, B, 2006) |
| "Pain is a well-known complication of intravenous administration of propofol, and to find out the optimal method to decrease this pain, we studied 4 methods of delivering propofol." | ( Abu-Ali, HM; Abu-Halaweh, SA; Badran, IZ; Massad, IM, 2006) |
| "Chronic pain is a costly and prevalent problem." | ( Wallace, JM, 2006) |
| "Neuropathic pain is a common symptom in many diseases of the peripheral nervous system." | ( Cornblath, DR; Dühmke, RM; Hollingshead, J, 2006) |
| "Chronic pain is defined as intractable pain caused by abnormal pain transmission or impairment of the pain control system per se." | ( Fujita, S; Futami, S; Kodama, T; Kunitake, A; Nagamachi, S; Nishii, R; Takasaki, M; Tamura, S; Uno, T; Wakamatsu, H; Yano, T, 2006) |
| "Breakthrough pain is well-characterized in cancer patients but not in patients with chronic noncancer pain." | ( Bennett, DS; Brennan, M; Portenoy, RK; Rauck, R; Shoemaker, S; Simon, S; Taylor, D, 2006) |
| "Breakthrough pain is a common problem in patients with cancer, and is associated with significant morbidity among this group of patients." | ( Davies, AN, 2006) |
| "Chronic pain is common after a traumatic brain injury." | ( Drance, E; Gallagher, R; Higginbotham, S, 2006) |
| "Chronic pain is a major problem for the individual and for society." | ( Bountra, C; Schweinhardt, P; Tracey, I, 2006) |
| "Pain is a universal complaint, which needs further investigations for new pain relieving agents." | ( Dashti-Rahmatabadi, MH; Hejazian, SH; Morshedi, A; Rafati, A, 2007) |
| "Joint pain is a primary symptom in knee osteoarthritis (OA), but the effect of pain and pain relief on the knee joint mechanics of walking is not clear." | ( Alkjaer, T; Bliddal, H; Danneskiold-Samsøe, B; Graven-Nielsen, T; Henriksen, M; Lund, H; Simonsen, EB, 2006) |
| "Pain is a complex experience, involving both the physiological responses of the nociceptive system and the processing of that information in brain regions associated with emotion." | ( Desaiah, D; Perahia, DG; Pritchett, YL; Raskin, J, 2006) |
| "Breast pain is a common complaint among lactating women." | ( McKenna, DS; Page, SM, 2006) |
| "Pain is a common and feared problem for those with advanced cancer." | ( Auret, K; Pickstock, S, 2006) |
| "Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system." | ( Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J, 2006) |
| "Chronic neuropathic pain is estimated to affect up to 8% of the world's population; the numerous analgesic compounds currently available are largely ineffective and act through a small number of pharmacological mechanisms." | ( Ellison, M; McIntosh, JM; Olivera, BM; Parker, R; Vincler, M; Wittenauer, S, 2006) |
| "Pain is developed in the trapezius and masseter muscles during repeated isometric contraction." | ( Brodda Jansen, G; Ernberg, M; Hedenberg-Magnusson, B; Kopp, S, 2006) |
| "Pain is a common symptom in many somatic illnesses." | ( Hajak, G, 2006) |
| "Radiation of pain is a perplexing clinical problem." | ( Coghill, RC; Quevedo, AS, 2007) |
| "Pain is the most common discomfort experienced by children with cancer and occurs in almost 89% of patients in an advanced stage of the disease." | ( Barone, G; Chiaretti, A; Lazzareschi, I; Liotti, L; Riccardi, R; Ruggiero, A, 2007) |
| "Pain is a complex human trait." | ( Bhat, SV; Bruera, E; Kaasa, S; Klepstad, P; Rakvåg, T; Reyes-Gibby, CC; Shete, S; Skorpen, F, 2007) |
| "Pain is regarded as a risk factor in pressure ulcer development by contributing to immobility." | ( Baron, C; Fromy, B; Leftheriotis, G; Roquelaure, Y; Saumet, JL; Sigaudo-Roussel, D, 2007) |
| "Neuropathic pain is emerging as a major complication of bortezomib." | ( Burton, AW; Cata, JP; Dougherty, PM; Giralt, S; Villareal, H; Weng, HR, 2007) |
| "Pain is the major reason patients seek medical care." | ( Okuse, K, 2007) |
| "Spontaneous pain is the chief clinical manifestation of peripheral nerve injury; however, a role for I(h) in spontaneous pain has not been described." | ( Ao, H; Brown, SM; Chang, L; Chaplan, SR; Dubin, AE; Higuera, ES; Lee, DH; Luo, L, 2007) |
| "The reason for the pain is assumed to be the aqueous phase of the propofol emulsion." | ( Boulaadass, S; Gräf, G; Mencke, T; Molter, GP; Silomon, M; Soltész, S, 2007) |
| "Testicular pain is rarely caused by medications." | ( Hiatt, WH; Linnebur, SA, 2007) |
| "As severe pain is most common and dreadful symptom in cancer patients, all physicians should learn correct information about opioid analgesics." | ( Kimura, N; Noguchi, T, 2007) |
| "Chronic non-cancer pain is an increasing problem in health care." | ( Blake, S; Ruel, B; Seamark, C; Seamark, D, 2007) |
| "Chronic non-cancer pain is associated with high levels of distress and psychosocial impairment." | ( Blake, S; Ruel, B; Seamark, C; Seamark, D, 2007) |
| "Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain." | ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007) |
| "Treating ischemic pain is often unsatisfactory." | ( Irnich, D; Lang, PM, 2007) |
| "Pain is a common symptom and significant problem for older adults; up to one half of community-dwelling older adults have pain that interferes with normal function." | ( Allman, RM; Bodner, EV; Ritchie, CS; Sawyer, P, 2006) |
| "Breakthrough pain is a prevalent and serious problem in patients with cancer." | ( Farrar, JT; Fisher, K; Hagen, NA; Victorino, C, 2007) |
| "The ejaculatory pain is associated with prostatitis, chronic pelvic pain syndrome, benign prostatic hyperplasia, and ejaculatory duct obstruction; it is also described in patients after procedures like radical prostatectomy." | ( Ilie, CP; Mischianu, DL; Pemberton, RJ, 2007) |
| "Since pain is the main syndrome of dysmenorrhea, the present investigation was carried out to evaluate the analgesic activity of LIG in vivo." | ( Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L, 2007) |
| "Chronic muscle pain is a problem with high prevalence in clinical practice and its pharmacological treatment is difficult." | ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007) |
| "Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes." | ( Aloisi, AM; Bachiocco, V; Bertaccini, A; Ceccarelli, I; Costantino, A; Meriggiola, MC; Stefani, R, 2007) |
| "The assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets." | ( Adwanikar, H; Fu, Y; Han, JS; Ji, G; Neugebauer, V, 2007) |
| "Although pain is a frequent feature in patients with cancer, its etiology is still poorly understood." | ( De Hert, S; Deseure, K; Hans, G; Robert, D, 2007) |
| "Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients." | ( Alkjaer, T; Bliddal, H; Danneskiold-Samsøe, B; Graven-Nielsen, T; Henriksen, M; Lund, H; Simonsen, EB, 2007) |
| "Anticipation to pain is thought to increase the suffering of chronic pain patients." | ( Lujan, BJ; Peskett, GD; Rogers, R; Schweinhardt, P; Tracey, I; Wise, RG, 2007) |
| "Pain is a public health disaster." | ( Lipman, AG, 2007) |
| "Although acute pain is frequently reported by patients admitted to the emergency room, it is often insufficiently evaluated by physicians and is thus undertreated." | ( Blanc, C; Buclin, T; Decosterd, I; Givel, JC; Hugli, O; Mouhsine, E; Tamchès, E; Yersin, B, 2007) |
| "Severe acute pain is common in sickle cell disease (SCD)." | ( Adewoye, AH; Ma, Q; McMahon, L; Nolan, V; Steinberg, MH, 2007) |
| "Dyspnea and pain are similarly unpleasant, alarming physical sensations, but studies examining both sensations in combination are lacking." | ( Dahme, B; von Leupoldt, A, 2007) |
| "Background pain is treated with long-acting opioids." | ( Christrup, LL; Hansen, OB; Højsted, J; Jarvig, L; Jensen, NH; Jonsson, T; Olesen, AE; Sjøgren, P; Sonne, NM; Sørensen, JT, 2007) |
| "Pain is the most distressing symptom in patients with breast carcinoma and can occur at all stages of the disease due to the cancer per se as well as due to various diagnostic and treatment modalities." | ( Kumar, S; Saxena, AK, 2007) |
| "Nociceptive cancer pain is characterized by its frequent instability." | ( Binhas, M; Krakowski, I; Marty, J, 2007) |
| "Pain is the most prominent feature of IC and current therapies provide limited relief." | ( Leventhal, L; Piesla, M; Wantuch, C, 2007) |
| "Propofol injection pain is a well-known problem in pediatric anesthesia." | ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007) |
| "Pain is a multistep process that originates in the peripheral nervous system at the site of injury, is transmitted and processed within the central nervous system, and is perceived at the level of the cerebral cortex." | ( Gordon, SM, 2007) |
| "Pain is a major issue for patients suffering from many different types of wounds in particular those with burn injuries." | ( Cleland, H; Wasiak, J, 2007) |
| "Cancer pain is a prevalent and serious public health issue, and more effective treatments are needed." | ( Chary, S; du Souich, P; Fisher, KM; Hagen, NA; Lapointe, B; Moulin, D; Ngoc, AH; Sellers, E, 2007) |
| "Chronic pain is maintained in part by long-lasting neuroplastic changes in synapses and several proteins critical for synaptic plasticity are degraded by the ubiquitin-proteasome system (UPS)." | ( Bakalkin, G; Bazov, I; Ekström, TJ; Gardell, LR; Kowal, J; Ossipov, MH; Porreca, F; Usynin, I; Yakovleva, T, 2007) |
| "Neuropathic pain is notoriously difficult to manage and only a few classes of drugs may provide adequate benefits." | ( Lind, G; Linderoth, B; Schechtmann, G; Winter, J, 2007) |
| "Visceral pain is one of the most common forms of pain and for which new drugs would be welcome." | ( Meymandi, MS; Sepehri, G, 2008) |
| "Pain is experienced by most cancer patients and represents an important issue in the clinical setting." | ( Mystakidou, K; Tsiatas, M; Tsilika, E; Vlahos, L, 2007) |
| "Pain is often considered an expected concomitant of aging, and older patients are considered more sensitive to opioids." | ( Arcuri, E; Mercadante, S, 2007) |
| "Immunization pain is a global public health issue." | ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007) |
| "Pain is a common problem, and has been both under-recognized and under-treated." | ( Chai, MO; Donohoe, P; Edmonds, PM; Higginson, IJ; Murtagh, FE, 2007) |
| "WHO declared that pain is a relevant problem in public health and that opioids are the gold standard therapy for the treatment of moderate to severe pain." | ( Chinellato, A; Giusti, P; Roggeri, D; Saramin, C; Terrazzani, G; Zusso, M, 2007) |
| "Pain is a common symptom experienced by people with osteoarthritis and rheumatoid arthritis and impacts upon mobility and quality of life." | ( While, A; Ying, KN, 2007) |
| "Pain is an unpleasant sensation that originates from ongoing or impending tissue damage." | ( Beaulieu, P; Guindon, J; Walczak, JS, 2007) |
| "Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family." | ( Friedrichsdorf, SJ; Kang, TI, 2007) |
| "clinical pain are summarized." | ( Craft, RM, 2007) |
| "Pain is the insignia of sickle cell disease and the acute painful crisis is the number-one cause of hospital admissions." | ( Ballas, SK, 2007) |
| "As pain is very dynamic, close monitoring is recommended." | ( Jensen, NH; Lundorff, LE, 2007) |
| "Relief of pain is an important issue for nurses." | ( Burke, D; Johnson, H; Newell, R; Parapia, L; Plews, C, 2008) |
| "The treatment of pain is definitely the main priority." | ( Lukas, A, 2007) |
| "The causes of this pain are unknown, but are likely to involve the action of tumour-associated mediators and their receptors." | ( Adriaensen, H; Deseure, K; Hans, G, 2008) |
| "Pain is one of the symptoms that many tumor patients are especially afraid of in the final phase of their illness." | ( Maier, A; Maier, R; Müller-Busch, C, 2008) |
| "Cancer pain is a serious public health issue and more effective treatments are needed." | ( du Souich, P; Dubuc, B; Hagen, NA; Lapointe, B; Love, R; Ngoc, AH; Ong-Lam, M; Walde, D, 2008) |
| "Pain is a common symptom for patients with cancer, and opioids are the treatment of choice for moderate or severe cancer-related pain." | ( du Bois, RM; Gretton, S; Riley, J; Ross, JR; Sato, H; Taegetmeyer, AB; Welsh, KI, 2008) |
| "Breakthrough pain is a common and distinct component of cancer pain that is usually managed with normal release opioids (also known as rescue medication) either before or soon after its onset." | ( Zeppetella, G, 2008) |
| "Pain is experienced by a majority of cancer patients." | ( Kumar, MG; Lin, S, 2007) |
| "Sensitivity to pain is reduced during exercise." | ( Edwards, L; Kavussanu, M; Ring, C, 2008) |
| "Pain is the primary presenting symptom in the vast majority of inflammatory and noninflammatory rheumatic diseases." | ( Crofford, LJ, 2008) |
| "Currently, bone pain is treated primarily by opioid-based therapies, which are frequently accompanied by significant unwanted side effects." | ( Bauss, F; Ghilardi, JR; Halvorson, KG; Koewler, NJ; Mantyh, PW; Sevcik, MA; Sullivan, LJ, 2008) |
| "Pain is a complex experience composed of sensory and emotional components." | ( Minami, M, 2008) |
| "Chronic pain is the main symptom of postmenopausal osteoporosis." | ( Buttgereit, F; Krocker, D; Perka, C; Ullrich, H, 2008) |
| "Cancer pain is generally moderate to severe in intensity and persistent in nature." | ( Macleod, R; William, L, 2008) |
| "Therefore, pain is independent of pathology and inflammation, and histamine receptors represent direct therapeutic targets for pain in IC and other chronic pain conditions." | ( Berry, RE; Bryce, PJ; Guichelaar, LA; Klumpp, DJ; Rudick, CN, 2008) |
| "Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain." | ( Jiang, YQ; Sun, Q; Tu, HY; Wan, Y, 2008) |
| "Chronic abdominal pain is a common gastrointestinal symptom experienced by patients." | ( Price, DD; Verne, NG; Zhou, Q, 2008) |
| "Pain is a common symptom among cancer patients, yet many patients do not receive adequate pain management." | ( Hampshire, MK; Metz, JM; Simone, CB; Vapiwala, N, 2008) |
| "Pain is a problem in critically ill patients." | ( Alfaro, CG; González, PI; Hazaña, FH; Roldán, JM, 2008) |
| "Although sciatic pain is typically self-limiting, pharmacological analgesic therapy forms the mainstay of treatment." | ( Loiero, M; Memeo, A, 2008) |
| "Opioid-refractory pain is distressing because it is notoriously difficult to treat." | ( Haji, AG; Jain, D; Palat, G; Rajagopal, MR; Sharma, S; Singh, C, 2009) |
| "Chronic pain is the most difficult type of pain to treat." | ( DeLeo, JA; Horvath, RJ; Romero-Sandoval, EA, 2008) |
| "Self-reporting of pain is considered to be the primary source of information on pain intensity for older children but a validated observational tool will provide augment information to self-reports during painful procedures." | ( Finnström, B; Kokinsky, E; Nilsson, S, 2008) |
| "Although chronic pain is common, especially in elderly patients, its treatment often remains inadequate." | ( Birklein, F; May, A; Sternberg, S, 2008) |
| "Pain is the most common symptom in the world for which patients seek professional help." | ( Katz, WA, 2008) |
| "Neuropathic pain is challenging to treat, partly because of the systemic side effects of the commonly used medications." | ( Besson, M; Desmeules, J; Piguet, V, 2008) |
| "Chronic pain is now viewed as a biopsychosocial phenomenon, in which biological, psychological, and social factors are at work." | ( Forde, G; Stanos, S, 2007) |
| "Neuropathic pain is a chronic pain condition arising from injury or disease of the peripheral or central nervous system with a substantial impact on quality of life." | ( Finnerup, NB; Jensen, TS, 2007) |
| "Post-inflammatory pain is a poorly understood phenomenon." | ( Eijkelkamp, N; Elsenbruch, S; Heijnen, CJ; Holtmann, G; Kavelaars, A; Schedlowski, M, 2009) |
| "Severe pain is the leading symptom and many patients with ALDS are unable to tolerate compression therapy." | ( Medenica, LJ; Pavlović, MD; Vesić, S; Vuković, J, 2008) |
| "Pain is an experience that affects all aspects of a patient's life and effective pain management with strong opioids may help the patient to focus on the positive aspects of life, decreasing the focus on pain." | ( Cwiek, R; Gasik, R; Lisowska, B, 2008) |
| "Metastatic bone pain is characteristic of cancer pain." | ( Hara, S, 2008) |
| "Breast pain is a common symptom in patients attending breast clinics." | ( Ebrahimi, M; Hashemi, ES; Hooshmand, H; Izadi, S; Kaviani, A; Mehrdad, N; Najafi, M; Yunesian, M, 2008) |
| "Breast pain is a complex symptom that can be relieved significantly with reassurance." | ( Ebrahimi, M; Hashemi, ES; Hooshmand, H; Izadi, S; Kaviani, A; Mehrdad, N; Najafi, M; Yunesian, M, 2008) |
| "Pain is an unpleasant sensory and emotional experience." | ( Deyama, S; Kaneko, S; Katayama, T; Kondoh, N; Minami, M; Nakagawa, T; Yamaguchi, T; Yoshioka, M, 2009) |
| "Intrusive pain is likely to have a serious impact on older people with limited ability to respond to additional stressors." | ( Blyth, FM; Couteur, DGL; Creasey, H; Cumming, RG; Handelsman, DJ; Naganathan, V; Rochat, S; Sambrook, PN; Seibel, MJ; Waite, LM, 2008) |
| "Pain is now the "5th vital sign" and physicians face disciplinary action for failure to adequately relieve pain." | ( Flower, K; Galloway, GP; Mendelson, J; Pletcher, MJ, 2008) |
| "Chronic pain is one of the most frequent and distressing symptoms in patients suffering from bone metastases due to malignant disease." | ( Fischer, M; Kampen, WU, 2008) |
| "Arthritic pain is a common and disabling problem for many older adults." | ( Doherty, JB; Yoon, E, 2008) |
| "Clinically, pain is a complex phenomenon consisting of both sensory and affective aberrations that can persist indefinitely." | ( Cummons, TA; Hummel, M; Lu, P; Whiteside, GT, 2008) |
| "Pain is an important and often under-treated symptom of life-threatening illness." | ( Mathieu, N; Tuna, T, 2008) |
| "Pain is the result of an emotional and sensory experience and preclinical models of OA can thus be useful to better understand the underlying mechanisms of the disease and test new therapeutic options." | ( Dickenson, AH; Ghandehari, J; Vonsy, JL, 2009) |
| "neuropathic pain) is not very satisfactorily managed." | ( Fürst, Z, 2008) |
| "Osteoarthritis pain is a significant problem for our aging population." | ( Bentley, S; Fan, MY; Gardner, G; Sullivan, MD, 2009) |
| "Chronic pain is difficult to diagnose and treat, and is often comorbid with psychiatric conditions." | ( Arnold, LM; Glazer, WM; Jain, R, 2008) |
| "Deficiencies in pain care within the developing world are starting to be realized." | ( Boonyawatanangkool, K; Evans, J; Finley, GA; Forgeron, PA; Jongudomkarn, D; Pairojkul, S; Siripul, P; Sriraj, W; Thienthong, S, 2009) |
| "However, chronic pain is practically useless and leads to psychopathological changes." | ( Murányi, M; Radák, Z, 2008) |
| "Neuropathic pain is a disease caused by a lesion or dysfunction of the nervous system." | ( Barrot, M; Doridot, S; Freund-Mercier, MJ; Hein, L; Petit-Demoulière, N; Tessier, LH; Yalcin, I, 2009) |
| "Pain is associated with swallowing abnormalities in dysphagic patients." | ( Iwata, K; Kitagawa, J; Tsujimura, T; Ueda, K, 2009) |
| "Since pain is permanent, the continuous administration of the analgesic is recommended rather than an on demand administration." | ( Faymonville, ME; Libbrecht, D, 2008) |
| "Pain is a physiological state promoting protective responses to harmful episodes." | ( Cohen, A; Sagron, R; Segal-Hayoun, Y; Somech, E; Zilberberg, N, 2009) |
| "Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood." | ( Andresen, T; Christrup, LL; Olesen, AE; Upton, RN, 2009) |
| "Gout and pain are synonymous, and a study in this issue of the BJP reports a novel anti-nociceptive effect of allopurinol, the drug most commonly used to treat gout." | ( Connor, M, 2009) |
| "Pain is the most common complaint in the medical field and the identification of compounds that can effectively treat painful states without induction of side-effects remains a major challenge in biomedical research." | ( Bonacorso, HG; Cechinel, CA; Dalmolin, GD; Ferreira, J; Gewehr, C; Lourega, RV; Martins, MA; Oliveira, SM; Rubin, MA; Sehnem, RC; Wentz, A; Zanatta, N, 2009) |
| "Chronic noncancer pain is common and use of opioids is increasing." | ( Ballantyne, JC; Chou, R; Fanciullo, GJ; Fine, PG; Miaskowski, C, 2009) |
| "Cancer pain is often labeled as mixed mechanism pain and is not easily classified as exclusively nociceptive or NP." | ( Aielli, F; Casuccio, A; David, F; Ferrera, P; Gebbia, V; Mangione, S; Mercadante, S; Porzio, G; Verna, L, 2009) |
| "Pain is the main acute adverse event during photodynamic therapy of skin lesions." | ( Haedersdal, M; Wiegell, SR; Wulf, HC, 2009) |
| "In inflammation, pain is regulated by a balance of pro- and analgesic mediators." | ( Brack, A; Hackel, D; Labuz, D; Mousa, S; Rittner, HL; Schaefer, M; Schäfer, M; Stein, C; Stolz, A; Voigt, P, 2009) |
| "Pain is a common symptom that patients describe and clinicians have to manage." | ( Bennett, MI; Cawley, D, 2009) |
| "Breakthrough pain is a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain." | ( Zeppetella, G, 2009) |
| "Referred pain is a significant clinical problem, and commonly occurs with pain originating in muscle but not from skin." | ( Gandevia, SC; Henderson, LA; Macefield, VG; Rubin, TK, 2009) |
| "Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids." | ( Imai, T; Inoue, K; Nagata, K; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T, 2009) |
| "Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients." | ( Kim, JS, 2009) |
| "Pain is frequently reported by patients with Parkinson's disease (PD)." | ( Ebersbach, G; Nebe, A, 2009) |
| "Iatrogenic pain is a serious problem, particularly in preterm infants of low gestational age." | ( Büchi, S; Cignacco, E; Hamers, J; Müller, R; Nelle, M; Schütz, N; Stoffel, L; van Lingen, RA; Zimmermann, L, 2009) |
| "Appreciation of pain is subject to the level of CNS lesions because during severe disorders behavioral reaction to pain is certainly reduced." | ( Gadzhieva, NN, 2009) |
| "Moderate to severe pain is commonly experienced by cancer and non-cancer patients." | ( Canneti, A; De Polo, C; Fabrizio Sabato, A; Gatti, A; Gubernari, M; Luzi, M; Mammucari, M; Occhioni, R; Reale, C, 2009) |
| "Multimodal pain is comprised of nociceptive/inflammatory and neuropathic components." | ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "Although pain is the major stumbling block deterring patients and physicians from choosing this treatment option, it is not the only one." | ( Benohanian, A, 2009) |
| "Pain is the most frequent functional aspect found with cancers." | ( Adoubi, I; Coulibaly, JD; Echimane, KA; Oseni, A; Touré, M, 2009) |
| "Neuropathic pain is often difficult to treat due to a complex pathophysiology." | ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "Under-treatment of pain is frequently reported, especially among seniors, with chronic non-cancer pain most likely to be under-treated." | ( Carrie, AG; Grymonpre, RE; Metge, CJ; Sadowski, CA; St John, P, 2009) |
| "Neuropathic pain is still an under-diagnosed and undertreated problem in third world countries." | ( Chatterjee, A; Choudhary, AH; Jain, PN; Sareen, R, 2009) |
| "Pain is frequent and often severe among women with HIV requiring medical management." | ( Anastos, K; Heikes, B; Karim, R; Richardson, JL; Weber, K; Young, M, 2009) |
| "The expectation of pain is created through the use of mild electric shocks to the top of the foot." | ( Berns, GS; Capra, CM; Moore, S; Noussair, C, 2008) |
| "Pain is a frequent complaint of hemodialysis (HD) patients, yet information regarding its causes and frequency is relatively scarce." | ( Bernheim, J; Golan, E; Haggiag, I; Os, P, 2009) |
| "Pain, is a major symptom which often accompanies cancer." | ( Baba-Hamed, N; Chouahnia, K; Des Guetz, G; Luu, M, 2009) |
| "Because persistent pain is frequently associated with psychological and emotional dysfunction, studies of the neural circuits and the molecular mechanisms involved in the affective component of pain may have considerable clinical importance in the treatment of chronic pain." | ( Minami, M, 2009) |
| "Pain is a common cause of disability in osteoarthritis." | ( Bennett, RM; Chappell, AS; Collins, H; Iyengar, S; Li, LC; Liu-Seifert, H; Ossanna, MJ; Skljarevski, V, 2009) |
| "Oesophageal pain is one of the most common reasons for physician consultation and/or seeking medication." | ( Blackshaw, LA; Page, AJ, 2009) |
| "Itch and pain are two distinct sensations." | ( Chen, ZF; Liu, XY; Meng, XL; Sun, YG; Yin, J; Zhao, ZQ, 2009) |
| "The way the pain is induced, assessed and summarized is very important for the sensitivity of the pain models." | ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Olesen, AE; Staahl, C, 2009) |
| "Although pain is a common sensation, it encompasses multiple neurobiologic components, of which NO is only one." | ( Gordh, T; Miclescu, A, 2009) |
| "Knee pain is predominant among osteoarthritis (OA) patients, but the mechanism is poorly understood." | ( Higashi, M; Moriya, H; Nakagawa, K; Ogino, S; Sasho, T; Suzuki, M; Takahashi, K; Yamaguchi, S, 2009) |
| "Pain is a common patient complaint during dermal filler injections." | ( Bank, DE; Boyd, CM; Gold, MH; Murphy, DK; Thomas, JA; Weinkle, SH, 2009) |
| "Pain is one of the most common symptoms in cancer patients." | ( Davis, MP; Lagman, RL; Lasheen, W; Shaheen, PE; Walsh, D, 2009) |
| "Chronic pain is a major clinical problem and opiates are often the only treatment, but they cause significant problems ranging from sedation to deadly respiratory depression." | ( Evans, MS; Jeffry, JA; Parihar, A; Premkumar, LS; Sikand, P; Yu, SQ, 2009) |
| "The presence of leg pain is an independent predictor of a patient's choice for operative over nonoperative care." | ( Berven, S; Bridwell, K; Fu, KM; Glassman, S; Hamill, C; Horton, W; Ondra, S; Schwab, F; Shaffrey, CI; Shainline, M; Smith, JS, 2009) |
| "Pain is known to be processed by a complex neural network (neuromatrix) in the brain." | ( Chen, J; Chen, XF; He, XS; He, Y; Li, H; Liu, MG; Wang, DD; Wang, Y; Yuan, DL; Zhang, FK; Zhao, XY, 2009) |
| "Cancer pain is a referent for disease status and has existential meaning, with the introduction of morphine becoming a metaphor for impending death." | ( Flemming, K, 2010) |
| "Pain is one of the most common reasons for admission to hospital for patients suffering from AIDS." | ( Evers, S; Hahn, K; Husstedt, IW; Kästner, F; Reichelt, D, 2009) |
| "Chronic neuropathic pain is underrecognized and undertreated, yet primary care physicians are uniquely placed on the frontlines of patient management, where they can play a pivotal role in treatment and prevention through diagnosis, therapy, follow-up, and referral." | ( Backonja, MM; Baron, R; Bennett, MI; Bouhassira, D; Cruccu, G; Haanpää, ML; Hansson, PT; Jensen, TS; Kauppila, T; Rice, AS; Smith, BH; Treede, RD, 2009) |
| "Cancer pain is one kind of the most common and severe kinds of chronic pain." | ( Gao, Q; Gu, X; Jin, Y; Ma, Z; Mei, F; Wang, J; Xia, X; Zhang, J; Zhou, X, 2010) |
| "Pain is a major issue after burns even when large doses of opioids are prescribed." | ( Berger, MM; Chiolero, RL; Davadant, M; Koch, N; Maravic, P; Marin, C; Pinget, C; Raffoul, W; Wasserfallen, JB, 2010) |
| "Pain is a complex experience involving extensive interactions between brain and spinal cord processes." | ( Arsenault, M; Piché, M; Rainville, P, 2009) |
| "Intensive pain is difficult to control with standard analgesics." | ( Aleksić-Shihabi, A; Buca, A; Jukić, I; Titlić, M; Tonkić, A, 2009) |
| "Pain is a major symptom in 70% of patients with advanced cancer." | ( Dale, O; Doehring, A; Klepstad, P; Lötsch, J, 2010) |
| "Neuropathic pain is usually persistent and there is no effective treatment." | ( Gao, Y; Li, G; Li, X; Lin, J; Linag, S; Liu, H; Liu, S; Xu, C; Zhang, A; Zhang, Y; Zhong, X, 2010) |
| "(1) Intermittent pain is a major problem in patients with cancer, (2) NBP is a common but under-recognized form of cancer pain, (3) NBP is less defined and controlled than BP, (4) incident NBP accounts for 40% of all incident cancer pain, and (5) variable IP definitions and classifications make comparisons between studies difficult." | ( Davis, M; Lasheen, W; Sarhill, N; Walsh, D, 2010) |
| "Neuropathic pain is regarded as one of the main causes of cancer pain refractory to standard opioid therapy in palliative care." | ( Shimoyama, N; Takahashi, H, 2010) |
| "Neuropathic pain is induced by injury or disease of the nervous system." | ( An, JX; Chu, GY; Guo, XY; He, HX; Tang, Y; Yu, CP, 2009) |
| "Pain is frequently reported and often undertreated in the elderly population." | ( Mort, JR; Schroeder, SD, 2009) |
| "Neuropathic pain is a common problem in clinical practice, affecting patients physically, emotionally, financially, and socially." | ( Moradimehr, A; Shah, TH, 2010) |
| "Neuropathic pain is relatively uncommon in children." | ( Dworkin, RH; Krane, EJ; LeBel, AA; Treede, RD; Walco, GA, 2010) |
| "Pain is among the most frequently reported, bothersome, and disabling symptoms described by patients with rheumatoid arthritis (RA), and the experience of pain is partially shaped by catastrophizing, a set of cognitive and emotional pain-related processes." | ( Bathon, J; Bingham, CO; Campbell, C; Edwards, RR; Giles, J; Haythornthwaite, JA, 2010) |
| "Pain is historically considered a cardinal sign of acute inflammation and a predominant symptom of IOIS." | ( Boothe, KH; Eckermann, DR; Musick, AN; Slagle, AM; Slagle, WS, 2010) |
| "Perineal pain is a common but poorly studied adverse outcome following childbirth." | ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010) |
| "However, pain is often inadequately managed in elderly people, which undermines quality of life." | ( Finco, G; Lussier, D; Richarz, U, 2010) |
| "Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS)." | ( Kivell, B; Prisinzano, TE, 2010) |
| "Pain is a complex subjective phenomenon that so far cannot be objectively quantified by any standardized procedure." | ( Auffermann, W; Lorenz, J, 2010) |
| "Foot pain is highly prevalent and associated with foot deformity and leg and low back pain." | ( Lundbye-Christensen, S; Mølgaard, C; Simonsen, O, 2010) |
| "Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects." | ( Berta, T; Ji, RR; Liu, T; Park, JY; Serhan, CN; Xu, ZZ; Yang, R; Zhang, L, 2010) |
| "Visceral pain is a significant issue for patients, and the importance of treating pain is underestimated." | ( Bruno, L; Gottardi, M; Liguori, S; Micheletto, G, 2010) |
| "Neuropathic pain is a recognized type of pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue." | ( Cahill, CM; Leung, L, 2010) |
| "Cancer pain is debilitating and has multidimensional consequences." | ( Cheema, B; Davis, MP; Estfan, B; Lagman, RL; Legrand, SB; Riaz, M; Shaheen, PE; Walsh, D, 2010) |
| "Breakthrough pain is defined as transitory flares of pain." | ( Davis, MP, 2010) |
| "Chronic noncancer pain is highly prevalent with associated negative effects on function and quality of life of the individuals involved." | ( Benyamin, R; Datta, S; Manchikanti, L; Smith, H; Vallejo, R, 2010) |
| "Neuropathic pain is difficult to treat." | ( Alkhalaf, A; Bilo, HJ; Kleefstra, N; Mijnhout, GS, 2010) |
| "Pain is a complex and subjective experience that involves not only the transduction of noxious stimuli by nociceptive fibers, but also the cognitive and emotional processing by the brain." | ( Chen, T; Chen, Y; Dang, Y; Lai, J; Xu, M; Yan, C; Zhu, J, 2010) |
| "Pain is the most frequent complication of this haemoglobin disorder." | ( Ahmedzai, SH; Wright, J, 2010) |
| "Neuropathic pain is a highly debilitating chronic pain following damage to peripheral sensory neurons and is often resistant to all treatments currently available, including opioids." | ( Hasegawa, S; Inoue, K; Ishii, S; Kohro, Y; Shimizu, T; Shiratori, M; Tsuda, M, 2010) |
| "The pain is often not completely relieved despite the use of medication." | ( Ortiz, MI, 2010) |
| "Chronic pain is often equated with chronic stress yet the relationship between chronic pain and hypothalamic-pituitary-adrenal (HPA) axis activity is poorly understood." | ( da Silva, L; Jessop, DS; Keogh, E; Osborn, M; Turner-Cobb, JM, 2010) |
| "Neuropathic pain is a common problem following spinal cord injury (SCI)." | ( Ahmed, MM; Hasbargen, T; Kahle, KT; Li, L; Miranpuri, G; Resnick, D; Sun, D, 2010) |
| "Pain is one of the major adverse effects during and after the treatment." | ( Denk, K; Enk, A; Gholam, P; Hartmann, M; Sehr, T, 2010) |
| "Neuropathic pain is a major health issue and is frequently accompanied by allodynia (painful sensations in response to normally non-painful stimulations), and unpleasant paresthesia/dysesthesia, pointing to alterations in sensory pathways normally dedicated to the processing of non-nociceptive information." | ( Bebber, D; Decosterd, I; Gosselin, RD, 2010) |
| "Chronic pain is common and can be devastating to the patient and challenging to the health care provider." | ( Elhwairis, H; Reznich, CB, 2010) |
| "Pain is a significant problem in patients with cancer." | ( Brant, JM, 2010) |
| "Existential pain is more typical of a person uninterested in a transcendent context and may be more challenging to address in the health care context." | ( Balducci, L, 2010) |
| "Pain is a rare symptom in epileptic seizures." | ( Alving, J; Andersen, N; Atkins, MD; Beniczky, S; Dahl, M; Jovanovic, M; Wolf, P, 2011) |
| "Pain is the most common reason for seeking health care in the Western world and is a contributing factor in up to 80% of all emergency department (ED) visits." | ( Ali, S; Beno, S; Drendel, AL; Kircher, J, 2010) |
| "Chronic pain is a serious public health problem and is treated by diverse health care providers." | ( Breuer, B; Cruciani, R; Portenoy, RK, 2010) |
| "Alleviating pain is of high importance for children undergoing chemotherapy." | ( Gerr, H; Grigull, L; Hoy, L; Klein, C; Leonhardt, J; Linderkamp, C; Lüllmann, B; Metzelder, M, 2010) |
| "Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied." | ( Bushnell, MC; Mak, E; Nandhagopal, R; Schulzer, M; Stoessl, AJ; Troiano, AR, 2010) |
| "Pain is often underrecognized and undertreated among older people." | ( Bell, JS; Hartikainen, S; Lihavainen, K; Pokela, N; Sulkava, R, 2010) |
| "Pain is a frequent symptom in clinical practice." | ( Benvenuti-Falger, U; Böhmdorfer, B; Dovjak, P; Gosch, M; Iglseder, B; Lechleitner, M; Otto, R; Roller, RE; Sommeregger, U, 2010) |
| "Pain is a prominent symptom in radiotherapy-induced oral mucositis (OM)." | ( Larsson, B; Ling, IS, 2011) |
| "As pain is still undertreated in pediatric anesthesia, opioids should be used generously but well-considered." | ( Becke, K, 2010) |
| "Pain is a common feature of laminitic pathology and its management is an important component of the treatment regime for this disease." | ( Belknap, JK; Black, SJ; Loftus, JP; Williams, JM, 2010) |
| "Chronic pain is a major problem in primary care." | ( Friessem, CH; Willweber-Strumpf, A; Zenz, MW, 2010) |
| "Pain is a prevalent symptom affecting as many as 50% of community-dwelling older adults." | ( Javier, N; Tomas, M, 2010) |
| "Pain is one of the most prevalent conditions, which limits productivity and diminishes quality of life." | ( Brüning, CA; Nogueira, CW; Prigol, M; Roehrs, JA; Zeni, G, 2010) |
| "Pain is a common, often undertreated problem among patients with palliative needs." | ( Asch, SM; Cohen, A; Goebel, J; Hagenmeier, E; Lanto, A; Lorenz, KA; Meredith, LS; Rubenstein, LV; Sherbourne, CD; Shugarman, LR; Wen, L, 2010) |
| "Even when injection pain is reduced, the use of a premedication regimen clearly has additional value with respect to the patients' experience." | ( Adam, S; Dedic, A; Gommers, D; Van Bommel, J, 2010) |
| "Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment." | ( Dasilva, D; Freedman, SD; Fregni, F; Lenkinski, RE; Pascual-Leone, A; Potvin, K; Wang, X, 2011) |
| "Chronic pain is modeled experimentally through a variety of manipulations of sensory nerves including cutting, crushing, resection, and ligation." | ( Miller, DB; O'Callaghan, JP, 2010) |
| "Pain is an integral part of the defense mechanisms required for survival." | ( Hamet, P; Tremblay, J, 2010) |
| "Inflammatory pain is triggered by activation of pathways leading to the release of mediators such as bradykinin, prostaglandins, interleukins, ATP, growth factors and protons that sensitize peripheral nociceptors." | ( Cato, MJ; Cook, SP; Garsky, VM; Kane, S; Karczewski, J; Leitl, MD; Liang, A; Spencer, RH; Urban, MO, 2010) |
| "Cancer pain is unfortunately very prevalent, with opioids the mainstay of treatment." | ( Trescot, AM, 2010) |
| "Enhanced somatic pains are accompanied by mechanical hyperalgesia and allodynia in FM patients as compared with healthy controls." | ( Staud, R, 2010) |
| "Funicular leg pain is a rare presentation of cervical cord compression." | ( Chan, CK; Cho, JY; Choi, WC; Lee, HY; Lee, SH, 2011) |
| "The perception of pain is subject to powerful influences." | ( Tracey, I, 2010) |
| "Pain is a multidimensional sensory phenomenon that has evolved as a protective method for maintaining homeostasis and facilitating tissue repair." | ( Muir, WW, 2010) |
| "Chronic pain is often a symptom after local anaesthetic-induced nerve injury." | ( Adey-Viscuso, D; Meechan, JG; Renton, T; Yilmaz, Z, 2010) |
| "Chronic pain is not very common in patients who have had their inguinal hernias repaired with titanium-covered polypropylene mesh." | ( Schardey, H; Schopf, S; von Ahnen, M; von Ahnen, T, 2011) |
| " Self-management of pain is a critical component of arthritis care; however, limited mobility can restrict access to resources." | ( Ainscough, JL; Charity, S; Pujol, LA; Trudeau, KJ, 2010) |
| "Growing pains are common among children aged 2-12 years and are characterized by recurrent, self-limited, bilateral lower extremity pain, mostly in the afternoon and evening, and even at night, in an otherwise healthy child." | ( Harel, L, 2010) |
| "Pain is a complex biological phenomenon that encompasses intricate neurophysiological, behavioural, psychosocial and affective components." | ( McDougall, JJ, 2011) |
| "Long-term pain is a debilitating condition that is costly to treat and has a significant impact on patient quality of life." | ( Ahlbeck, K, 2011) |
| "Bone-cancer pain is a common and refractory cancer pain." | ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| "Pain is one of the most common reasons that patients seek treatment from health care professionals, often their primary care providers." | ( Lewis, ET; Trafton, JA, 2011) |
| "Breakthrough pain is a transient exacerbation of pain that occurs either spontaneously or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain." | ( Zeppetella, G, 2011) |
| "Although pain is common among advanced cancer patients, it can be controlled in a large proportion of patients." | ( Azoulay, D; Cialic, R; Jacobs, JM; Mor, EE; Stessman, J, 2011) |
| "Chronic pain is a common and debilitating symptom experienced in the context of numerous other physical and emotional symptoms by many patients with chronic kidney disease (CKD)." | ( Davison, JS; Davison, SN, 2011) |
| "Pain is a complex subjective experience that is shaped by numerous contextual factors." | ( Haggard, P; Kammers, MP; Longo, MR; Mancini, F, 2011) |
| "Central neuropathic pain is a frequent challenging complication after spinal cord injury (SCI), and specific therapeutic approaches remain elusive." | ( Held-Feindt, J; Knerlich-Lukoschus, F; Lucius, R; Mehdorn, HM; von der Ropp-Brenner, B, 2011) |
| "However, PDT pain is multifactorial and choice of photosensitiser is probably not a major pain determining factor." | ( Attili, SK; Dawe, R; Ibbotson, S, 2011) |
| "Pain is one of the most common reasons for seeking medical care and the frequency of prescription of opioid analgesics by both primary care physicians and specialists has increased." | ( Asensio-Samper, JM; De Andrés-Ibáñez, J; Fabregat-Cid, G; López-Alarcón, MD; Villanueva-Pérez, V, 2011) |
| "Pain is a major health concern even though numerous analgesic agents are available." | ( Brosnan, R; Hammock, BD; Hegedus, C; Inceoglu, B; Jinks, SL; Morisseau, C; Rose, T; Schebb, NH; Ulu, A; Wagner, K, 2011) |
| "Local forearm/wrist pain is relatively frequent in this setting, and is not significantly prevented by intra-arterial lidocaine." | ( Agostoni, P; Biondi-Zoccai, GG; Moretti, C; Omedè, P; Romagnoli, E; Sangiorgi, G; Sciuto, F; Sheiban, I, 2011) |
| "Pain is prevalent among people who have cancer, and is one of the most feared and burdensome symptoms." | ( Daher, M, 2011) |
| "Back and knee pain is a widespread health problem and a serious threat to the quality of life (QOL) in middle-aged and older adults, as it frequently accompanies osteoporosis and osteoarthritis." | ( Fujii, Y; Fujita, T; Miyauchi, A; Nakajima, M; Ohue, M; Takagi, Y, 2011) |
| "Pain is one of the major nonmotor symptoms of Parkinson's disease." | ( Bartolo, M; Buscone, S; Martignoni, E; Pacchetti, C; Perrotta, A; Pierelli, F; Sandrini, G; Serrao, M; Tassorelli, C; Tinazzi, M; Zangaglia, R, 2011) |
| "Untreated pain is a major public health problem, but concerns about opioid misuse remain." | ( Buchbinder, R; Howes, F; Winzenberg, TB, 2011) |
| "Pain is among the most common reasons patients seek medical attention, and the care of patients with pain is a significant problem in the United States." | ( McCarberg, BH, 2011) |
| "Cancer pain is generally treated with pharmacological measures, relying on using opioids alone or in combination with adjuvant analgesics." | ( Leppert, W, 2011) |
| "Pain is a major issue for patients with severe burn." | ( Cleland, H; Costello, V; Ferraro, F; Konstantatos, A; Paul, E; Spinks, A; Wasiak, J, 2011) |
| "Pain is both a sensation and an emotional experience, and thus it has been defined as total pain." | ( Aruga, E, 2011) |
| "Chronic pain is a sensory experience that produces suffering and functional impairment and is the result of both sensory input as well as secondary adaptation of the nervous system." | ( Clark, MR; Treisman, GJ, 2011) |
| "Chronic pain is prevalent in patients with major depressive disorder (MDD)." | ( Liu, X; Mullins, CD; Wang, J, 2011) |
| "Pain is a common presenting complaint and there is considerable debate regarding the best practice for analgesia in the pre-hospital environment for trauma patients with severe pain." | ( Bernard, S; Cameron, P; Jennings, PA, 2011) |
| "Cancer pain is a distressing result of disease, both primary and metastatic, as well as complications caused by cancer treatment." | ( Cope, DK; Zhao, Z, 2011) |
| "Depression and pain are often diagnosed in the same patients." | ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| "Neuropathic pain is a compilation of somatosensory, cognitive and emotional alterations developing following nerve injuries." | ( Machelska, H, 2011) |
| "Pain is the predominant medical presentation to hospitalists for patients with sickle cell disease (SCD)." | ( Hassell, KL; Jordan, LB; Smith, WR, 2011) |
| "Rib fracture pain is notoriously difficult to manage." | ( Mayberry, JC; Peck, EG; Schreiber, MA; Zink, KA, 2011) |
| "Pain is the leading cause of emergency department visits, hospitalizations, and daily suffering in individuals with sickle cell disease (SCD)." | ( Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ, 2011) |
| "Pain is brought into play by a system which detects and transmits messages signaling pain." | ( de la Brière, A, 2011) |
| "The treatment of pain is an essential component of the clinical and ethical care of infants." | ( Bittle, M; Chang, K; Deluca, J; Hatfield, LA; Polomano, RC, 2011) |
| "Pain is one of the major adverse effects." | ( Denk, K; Enk, A; Gholam, P; Weberschock, T, 2011) |
| "Comparing pain is done in daily life and involves short-term memorizing and attention focusing." | ( Anti, S; Deichmann, R; Felden, L; Lötsch, J; Martin, T; Nöth, U; Oertel, BG; Preibisch, C; Walter, C, 2012) |
| "Evaluation of pain is a critical issue in human pathologies but also in animal experimentation." | ( Charlet, A; Poisbeau, P; Rodeau, JL, 2011) |
| "Pain is an unpleasant sensory perception warning of actual or impending tissue damage." | ( Neil, MJ, 2011) |
| "After the pain is resolved and the examination shows improvement, patients may gradually increase their level of activity." | ( Kapil, N; Patel, DS; Roth, M, 2011) |
| "Neuropathic pain is therefore initiated by HCN2-driven action potential firing in Na(V)1." | ( Berrocoso, EM; Chen, L; Emery, EC; McNaughton, PA; Young, GT, 2011) |
| "Cancer pain is common, occurring in up to 60% of patients and opioid conversion may be required for effective pain management." | ( Kutner, JS; Linnebur, SA; O'Bryant, CL; Yamashita, TE, 2008) |
| "Pain is common among opioid-dependent patients, yet pharmacologic strategies are limited." | ( Anderson, BJ; Herman, DS; Kettavong, M; Stein, MD; Tsui, JI, 2011) |
| "Pain is a public health problem whose management shows a series of deficiencies." | ( Barbosa, CG; Bianchini, KC; Kulkamp, IC, 2008) |
| "Chronic pain is a common neurological disease involving lasting, multifaceted maladaptations ranging from gene modulation to synaptic dysfunction and emotional disorders." | ( Bie, B; Cai, YQ; Pan, ZZ; Zhang, Z; Zou, F, 2011) |
| "Pain is characterized by its multi-dimensional nature, explaining in part why the pharmacokinetic/pharmacodynamic (PK/PD) relationships are not straightforward for analgesics." | ( Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K, 2012) |
| "Pain is still a primary concern in the emergency department." | ( Eslami, V; Farahmand, S; Hajiseyedjavady, H; Saeedi, M; Shahsavarinia, K, 2012) |
| "Pain is among the most frequent and distressing symptoms in terminally-ill cancer and, to date, many patients still experience uncontrolled pain." | ( Bordin, F; D'Addario, ME; Di Miele, D; Fava, A; Ferraccioli, A; Lanzetta, G; Ranucci, A; Rozzi, A; Salerno, M; Scirocchi, R; Terzoli, L, 2011) |
| "Cancer pain is one of the most severe types of chronic pain, and the most common cancer pain is bone cancer pain." | ( Duan, KZ; Mei, YA; Xu, Q; Zhang, XM; Zhang, YQ; Zhao, ZQ, 2012) |
| "The causes of back pain are very different and numerous, but mostly are due to vertebral, mechanical etiology, and rarely because of non vertebral, visceral etiology." | ( Kovac, I, 2011) |
| "Insomnia and limb pain are common problems in dialysis patients." | ( Malaki, M; Moazemi, S; Mortazavi, FS; Shoaran, M, 2012) |
| "Hand and wrist pain is a diagnostic challenge for hand surgeons and radiologists due to the complex anatomy of the involved small structures." | ( Bürkert, A; Huellner, MW; Hug, U; Schleich, FS; Schürch, M; Strobel, K; Veit-Haibach, P; von Wartburg, U, 2012) |
| "Pain is harmful to newborn infants." | ( Huber, JM; Pasek, TA, 2012) |
| "Pain is a global health challenge." | ( Li, JX; Zhang, Y, 2012) |
| "Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraints." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Whether ongoing pain is present in this model is unknown." | ( Brion, T; Davis, P; Dussor, GO; King, T; Liu, P; Okun, A; Ossipov, MH; Porreca, F; Remeniuk, B; Ren, J; Xie, J, 2012) |
| "Itch and pain are common symptoms in skin disease." | ( Evers, AW; Kraaimaat, FW; Kroeze, S; van de Kerkhof, PC; van Laarhoven, AI; van Riel, PL; Walker, AL; Wilder-Smith, OH, 2012) |
| "Cancer pain is one of the most severe chronic pains." | ( Gu, X; Liu, Y; Ma, Z; Zhang, J; Zhang, R; Zheng, Y, 2012) |
| "Bone cancer pain is difficult to treat and has a strong impact on the quality of life of patients." | ( Guo, F; Hang, LH; Ji, FH; Shao, DH; Wang, LN; Wang, XY; Xu, QN; Yang, JP; Yin, W; Zuo, JL, 2012) |
| "Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician's fear of the adverse effect of analgesia and lack of anesthetist present." | ( Guangyi, W; Guoxia, M; Hongtai, T; Jianqiang, Y; Jijun, Z; Lu, T; Ming, Y; Shichu, X; Wanfang, Z; Wannian, Z; Wen, N; Wenjun, H; Xiaoyan, H; Xiuqiang, M; Xiuying, D; Yinsheng, W; Yuxiang, L; Zhaofan, X, 2012) |
| "The degree of pain is highly variable and adults reports more pain than children." | ( Chapurlat, RD; Gensburger, D; Ghilardi, JR; Jimenez-Andrade, JM; Kelly, M; Mantyh, P, 2012) |
| "Severe pain is defined as rated seven or greater on a 0 to 10 age-appropriate numeric pain scale or equivalent." | ( an Fhailí, S; Barrett, MJ; Cronin, J; Grant, T; Hayden, J; McCoy, S; McMahon, C; Murphy, A; O'Sullivan, R; Wakai, A; Walsh, S, 2012) |
| "Pain is a major issue for patients suffering from many different types of wounds, in particular those with burn injuries." | ( Cleland, H; Danilla, S; Mahar, P; McGuinness, SK; Spinks, A; Wasiak, J, 2012) |
| "Because pain is a very common condition in children, such as after musculoskeletal injuries, many parents ask whether they can alternate over-the-counter analgesics to treat their children's pain." | ( Goldman, RD; Smith, C, 2012) |
| "Pain is associated with skin injections." | ( Al Dabbagh, Z; Al-Aboosi, M; Al-Qarqaz, F; Al-shiyab, D, 2012) |
| "Pain is associated with inhibition of muscle activity in the (painful) agonist and its non-painful antagonists and synergists, especially at higher intensities of muscle contraction." | ( Bank, PJ; Beek, PJ; Marinus, J; Peper, CE; van Hilten, JJ, 2013) |
| "Pain is undertreated and more complex to manage in these patients for a number of reasons, including complex anti-retroviral drug regimens, higher risks of side effects, and higher rates of comorbid psychiatric illness and substance abuse." | ( Krashin, DL; Merrill, JO; Trescot, AM, 2012) |
| "Bone cancer pain is chronic and often difficult to control with opioids." | ( Hasegawa, M; Kanbara, T; Kato, A; Minami, K; Nakamura, A; Narita, M; Nishiyori, A; Suzuki, T; Tomii, T, 2013) |
| "Pain is a common and significant feature of burn injury." | ( Cleland, H; Mahar, PD; Menezes, H; Paul, E; Spinks, AB; Wasiak, J, 2014) |
| "Fear of dental pain is a major barrier to children needing dental care." | ( Anand, P; Ashley, PF; Behbehani, A; Moles, DR; Parekh, S, 2012) |
| "Physical pain is common among individuals seeking treatment for opioid dependence." | ( Cunningham, CO; Fox, AD; Giovanniello, A; Ning, Y; Sohler, NL; Starrels, JL, 2012) |
| "MS-related pain is difficult to treat, since very little is known about the mechanisms underlying its development." | ( Kuner, R; Kurejova, M; Linker, RA; Lu, J; Tappe-Theodor, A; Wirotanseng, LN, 2012) |
| "Arthritis pain is a complex phenomenon involving intricate neurophysiological processing at all levels of the pain pathway." | ( Linton, P; McDougall, JJ, 2012) |
| "Pain is a common symptom in Parkinson's disease (PD) and accounts for substantial morbidity in up to 80 % of patients." | ( Ford, B; Sophie, M, 2012) |
| "Pain is undertreated." | ( Authier, N; Courty, P, 2012) |
| "Relief of pain is rewarding." | ( Ci, S; Eyde, N; Fields, HL; King, T; Navratilova, E; Okun, A; Ossipov, MH; Porreca, F; Qu, C; Xie, JY, 2012) |
| "Pain is present more often in younger individuals and in females and, according to the visual analogue scale (VAS), the intensity of pain is relatively high." | ( Borg, K; Werhagen, L, 2013) |
| "Pain is common in patients with post-polio syndrome." | ( Borg, K; Werhagen, L, 2013) |
| "Pain is a common symptom in multiple sclerosis (MS) and has recently been estimated to be experienced by up to 75 % of patients." | ( Messmer Uccelli, M; Solaro, C; Trabucco, E, 2013) |
| "Propofol injection pain is a frequent and a well-known complaint distressing for the patients." | ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "Pain is a negative emotional experience that is modulated by a variety of psychological factors through different inhibitory systems." | ( Arduino, C; Benedetti, F; Blanchard, C; Thoen, W; Vighetti, S, 2013) |
| "Pain is not a symptom generally associated with thalassaemia." | ( Carson, S; Coates, T; Dinu, B; Eile, J; Gerstenberger, E; Green, S; Haines, D; Martin, M; Mendoza, T; Oliveros, O; Schilling, L; Trachtenberg, F; Vichinsky, E, 2013) |
| "Pain is associated with stimulation of some behaviors (eg, withdrawal reflexes) but depression of many other behaviors (eg, feeding, locomotion, positively reinforced operant behavior)." | ( Carroll, FI; Negus, SS; Rosenberg, MB, 2013) |
| "FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety." | ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013) |
| "Chronic widespread pain is a hallmark of fibromyalgia (FM)." | ( Chang, Y; Decety, J; Do, Y; Han, SW; Kim, SH; Kim, SK; Lee, HJ; Lee, SJ; Nam, EJ; Seo, J; Song, HJ, 2013) |
| "Perineal pain is a common but poorly studied adverse outcome following childbirth." | ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013) |
| "Severe pain is associated with a decreased quality of life in patients with cancer." | ( Bennett, MI; Ke, W; Lihua, P; Su, M; Zejun, Z, 2013) |
| "Inflammatory pain is the result of a process that depends on neutrophil migration, cytokines and prostanoids release and oxidative stress." | ( Casagrande, R; Hohmann, MS; Mizokami, SS; Navarro, SA; Serafim, KG; Verri, WA, 2013) |
| "Chronic pain is usually treated with pharmacological measures using opioids alone or in combination with adjuvant analgesics that play an important role in the treatment of pain not fully responsive to opioids administered alone, especially in neuropathic, bone and visceral colicky pain." | ( Krajnik, M; Leppert, W; Wordliczek, J, 2013) |
| "Pain is the most common symptom reported in both the general population and the general medical setting." | ( Huang, X; Ji, JL; Li, C; Luo, YL; Wang, B, 2013) |
| "Pain is common in patients with liver disease, difficult to treat, and poorly understood." | ( Bielefeldt, K; Rogal, SS; Szigethy, E; Winger, D, 2013) |
| "As pain is the main problem associated with endometriosis, LNG-IUS placement is beneficial at the time of surgery when it is diagnosed." | ( Hertweck, P; LaJoie, AS; Loveless, M; Yoost, J, 2013) |
| "Pain is a complex experience composed of sensory and affective components." | ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| "Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment." | ( Atlas, LY; Kross, E; Lindquist, MA; Roy, M; Wager, TD; Woo, CW, 2013) |
| "Back pain is generally experienced to a high extent by patients scheduled for spinal stenosis surgery." | ( Jönsson, B; Sigmundsson, FG; Strömqvist, B, 2013) |
| "Pain is a frequently observed non-motor symptom of patients with Parkinson's disease." | ( Baumann, CR; Baumann-Vogel, H; Imbach, LL; Sürücü, O; Uhl, M, 2013) |
| "Itch and pain are closely related but distinct sensations." | ( Ji, RR; Liu, T, 2013) |
| "Pain is a problem that often has to be addressed in the prehospital setting." | ( Johansson, J; Nordgren, M; Sandström, E; Sjöberg, F; Sjöberg, J; Zetterström, H, 2013) |
| "Pain is the single most common reason why patients seek medical care." | ( Balding, L, 2013) |
| "Pain is common during colonic insufflation required for CT colonography." | ( Boellaard, TN; Eberl, S; Hollmann, MW; Kavaliauskiene, G; Peringa, J; Runge, JH; Schouten, LJ; Stoker, J; Tielbeek, JA; van der Paardt, MP, 2013) |
| "Pain is a ubiquitous yet highly variable experience." | ( Aziz, Q; Brammer, M; Coen, SJ; Droney, J; Farmer, AD; Furlong, PL; Giampietro, VP; Jafari, J; Kano, M; Kishor, J; Knowles, CH; Kumari, V; Lightman, SL; Paine, PA; Riley, J; Rossiter, HE; Shwahdi, M; Williams, SCR; Worthen, SF, 2013) |
| "Pain is experienced by the overwhelming majority of patients during their intensive care unit stay, but it remains an underappreciated problem." | ( Gélinas, C; Hallman, M; Herr, DL; Joffe, AM; Puntillo, K, 2013) |
| "Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it." | ( Longo, G; Osikowicz, M; Ribeiro-da-Silva, A, 2013) |
| "Pain is the major drawback of photodynamic therapy (PDT), an otherwise effective treatment for actinic keratoses (AKs)." | ( Buinauskaite, E; Buinauskiene, J; Valiukeviciene, S; Zalinkevicius, R, 2013) |
| "Chronic pain is thought to be partly caused by a loss of GABAergic inhibition and resultant neuronal hyperactivation in the central pain-modulating system, but the underlying mechanisms for pain-modulating neurons in the brain are unclear." | ( Lu, YG; Pan, ZZ; Wang, W; Wang, X; Zhang, Z, 2013) |
| "Acute pain is one of the main causes of hospital admission in sickle cell disease, with variable intensity and unpredictable onset and duration." | ( Faris, AS; Kausalya, R; Tawfic, QA, 2014) |
| "Pain is the most frequent and distressing symptom in cancer patients." | ( Hosoya, M; Matoba, M; Morita, T; Shima, Y; Yamaguchi, T, 2013) |
| "Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED)." | ( Alesi, A; Antonini, EF; Cordischi, C; Franceschi, F; Giacobelli, D; Iacomini, P; Marsiliani, D; Zuccalà, G, 2013) |
| "Pain is a common symptom associated with cancer and its treatment." | ( Abernethy, AP; Anghelescu, DL; Benedetti, C; Buga, S; Cleeland, C; Deleon-Casasola, OA; Dwyer, M; Eilers, JG; Ferrell, B; Green, M; Janjan, NA; Kamdar, MM; Kumar, R; Levy, MH; Lynch, M; McDowell, RM; Moryl, N; Nesbit, SA; Paice, JA; Rabow, MW; Swarm, RA; Syrjala, KL; Urba, SG; Weinstein, SM, 2013) |
| "Pain is a common and often severe pathological feature of cancers in bone, and is a significant impediment to the maintenance of quality of life of patients living with bone metastases." | ( Seidlitz, EP; Singh, G; Ungard, RG, 2014) |
| "Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment." | ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014) |
| "The level of pain is a major determinant for the outcome of any treatment of these fractures regardless of its location." | ( Cisari, C; Frizzi, L; Gimigliano, F; Gimigliano, R; Iolascon, G; Moretti, A, 2013) |
| "Ischemic pain is complex and poorly understood." | ( Boezaart, AP; Kucera, TJ, 2014) |
| "Pain is relatively infrequent in SCD infants and young children and commonly managed at home." | ( Aertker, L; Brodecki, D; Coleman, C; Dampier, C; Ely, B; Hyslop, T; Kesler, K; Leiby, B; Sendecki, JA; Stuart, M, 2014) |
| "Leg pain is a very common complaint in clinical medicine which deserves thorough investigation." | ( Machetanz, J; Schellong, S; Stelzner, C; Unger, L; Wollina, U, 2013) |
| "Pain is one of the major symptoms of the osteoarthritis (OA)." | ( Belen'kiĭ, DA; Borisenko, OV, 2013) |
| "Acute postoperative pain is not associated with pupillary diameter or PLRA." | ( Guglielminotti, J; Kantor, E; Longrois, D; Montravers, P, 2014) |
| "Pain is a major side effect thereof, and it affects the treatment compliance and acceptance." | ( Barge, J; Glanzmann, T; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2013) |
| "Pain is a complex disorder with neurochemical and psychological components contributing to the severity, the persistence, and the difficulty in adequately treating the condition." | ( Bohn, LM; Raehal, KM, 2014) |
| "Chronic pain is frequently treated with our most potent analgesics, the opioids." | ( Sloan, P, 2014) |
| "Greater neonatal pain is associated with higher internalizing behaviours in very preterm infants at 18 months corrected age, but it is unknown whether this relationship persists to school age." | ( Grunau, RE; Ranger, M; Synnes, AR; Vinall, J, 2014) |
| "Pain is one of the most common and distressing elements of suffering related to cancer and cancer treatment." | ( Davis, MP; Fielding, F; Sanford, TM, 2013) |
| "Pain is a significant and alarming symptom of cancer seriously affecting the activity and quality of life of patients." | ( Heigl, P, 2014) |
| "Pain is a prevalent complaint." | ( Gharaei, H; Shadlou, H, 2014) |
| "Bone cancer pain is a major clinical problem and remains difficult to treat." | ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014) |
| "Inflammatory pain is based on stimulation and sensitization of peripheral endings of sensory neurons (nociceptors) by pronociceptive mediators." | ( Denis, CV; Geisslinger, G; Linke, B; Meyer dos Santos, S; Nieswandt, B; Pierre, S; Scholich, K; Stegner, D; Suo, J; Zhang, DD, 2014) |
| "Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus." | ( Gurtskaia, G; Nebieridze, M; Nozadze, I; Tsagareli, MG; Tsiklauri, N, 2014) |
| "Pain is a troublesome non-motor symptom of Parkinson's disease (PD)." | ( Boroojerdi, B; Chaudhuri, KR; Ghys, L; Kassubek, J; Moran, K; Surmann, E; Trenkwalder, C; Zesiewicz, T, 2014) |
| "Acute dental pain is a recognised precipitant of unintentional paracetamol overdose and in a small but significant number of cases this results in hepatotoxicity." | ( Byers, J; Marney, C; Nayyer, NV, 2014) |
| "Leg pain is associated with back pain in 25-65% of all cases and classified as somatic referred pain or radicular pain." | ( Briffa, KN; Hall, TM; Lüdtke, K; Mallwitz, J; Rolke, R; Schäfer, AG; Treede, RD, 2014) |
| "Inflammatory and pain are major areas for drug discovery." | ( Dai, D; Deng, X; Huang, W; Lin, H; Qian, H; Qiu, Q; Wang, J, 2015) |
| "Bone cancer pain is the most severe among cancer pain and is often resistant to current analgesics." | ( Dohi, T; Kanematsu, T; Kitayama, T; Morita, K; Motoyama, N; Shiraishi, S; Uezono, Y, 2014) |
| "Pain is experienced during both the biopsy and the marrow aspiration." | ( Bressel, M; Milner, A; Spruyt, O; Wein, S; Westerman, D, 2014) |
| "Skin reactions and pain are commonly reported side effects of radiation therapy (RT)." | ( Gewandter, JS; Heckler, CE; Morrow, GR; Ryan, JL; Walker, J, 2013) |
| "The assessment of pain is critical for the welfare of horses, in particular when pain is induced by common management procedures such as castration." | ( Canali, E; Dalla Costa, E; Leach, MC; Lebelt, D; Minero, M; Stucke, D, 2014) |
| "How to reduce pain is a fundamental clinical and experimental question." | ( Maravita, A; Romano, D, 2014) |
| "Bone pain is the most notorious adverse effect caused by G-CSFs." | ( Copeland, L; Li, Q; Romeo, C, 2015) |
| "Pain is the most common symptom in patients with advanced cancer and often persists despite treatment." | ( Gough, N; Linch, M; Miah, AB, 2014) |
| "Cancer pain is complex and an understanding of the type of pain, the biology of the particular cancer as well as patient factors must be considered." | ( Gough, N; Linch, M; Miah, AB, 2014) |
| "Chronic pain is a multidimensional experience that not only includes changes in nociception but also impairments in emotional and cognitive functions, not often taken into account in preclinical research." | ( Ardid, D; Etienne, M; Grégoire, S; Marchand, F; Wattiez, AS, 2014) |
| "Chronic pain is an important public health problem that negatively impacts quality of life of affected individuals and exacts an enormous socio-economic cost." | ( Morimura, K; Ossipov, MH; Porreca, F, 2014) |
| "Propofol injection pain is a common and unsolved anaesthesia problem." | ( Jia, Y; Lei, W; Shen, Y; Wu, Q; Zhang, N, 2014) |
| "Propofol injection pain is increased by contact with PVC infusion tubing as a result of an increase in aqueous propofol concentration caused by di(2-ethylhexyl) phthalate leaching into the lipid emulsion." | ( Jia, Y; Lei, W; Shen, Y; Wu, Q; Zhang, N, 2014) |
| "Pain is a multidimensional experience, which includes sensory, cognitive, and affective aspects." | ( Baumkötter, J; Heitmann, H; Ploner, M; Schulz, E; Tiemann, L, 2014) |
| "Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms." | ( Colvin, LA; Currie, GL; Fallon, MT; Macleod, MR; Sena, ES, 2014) |
| "Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido." | ( Binik, YM; Chan, L; Chen, M; Farmer, MA; Foxen-Craft, E; Leja, A; MacIntyre, LC; Mapplebeck, JC; Mogil, JS; Niaki, T; Pfaus, JG; Sukosd, M; Tabry, V; Topham, L, 2014) |
| "The management of pain is an essential aspect of comprehensive cancer care." | ( Ahmed, E; Portenoy, RK, 2014) |
| "Pain is common in advanced malignancy but also prevalent in other non-malignant life-limiting diseases such as advanced heart disease; end stage renal failure and multiple sclerosis." | ( Harris, DG, 2014) |
| "Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome." | ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014) |
| "Experimental pain is known to affect neuroplasticity of the motor cortex as well as motor performance, but less is known about neuroplasticity of somatosensory processing in the presence of pain." | ( Dancey, E; Murphy, B; Srbely, J; Yielder, P, 2014) |
| "Hand pain is a major complaint in 80% of the patients with complete brachial plexus palsy; and, in 80% of these patients, the C5 root is ruptured and the C6-T1 roots avulsed from the spinal cord." | ( Bertelli, JA; Ghizoni, MF, 2014) |
| "Pain is the most prominent symptom of vasoocclusion, and hypercoagulability is a well-established pathogenic phenomenon in people with sickle cell disease." | ( Fedorowicz, Z; van Zuuren, EJ, 2014) |
| "Chronic pain is a major neurological disorder that can manifest differently between genders or sexes." | ( McCarson, KE; Ralya, A, 2014) |
| "Assessing pain is an important element of nursing skills." | ( Clavagnier, I, 2014) |
| "Pain is a common and highly debilitating complication for cancer patients significantly compromising their quality of life." | ( Dickenson, AH; Falk, S; Heegaard, A; Mercadante, S; Patel, R, 2015) |
| "Pain is common in head and neck cancer patients." | ( Miyazaki, T; Nishimura, K; Ohno, T; Satou, S; Yoshida, A, 2014) |
| "Neuropathic pain is caused by a variety of phenomena including sustained excitability in sensory neurons that reduces the pain threshold so that pain is produced in the absence of appropriate stimuli." | ( Abdelhak, B; Frietag, C; Menichella, DM; Miller, RJ; Ren, D; Shum, A, 2014) |
| "Pain is a primary symptom driving patients to seek physical therapy, and its attenuation commonly defines a successful outcome." | ( Bishop, MD; Hannibal, KE, 2014) |
| "Pain is the most common complaint in the medical field and the identification of novel compounds that can effectively treat painful states without causing side effects remains a major challenge in biomedical research." | ( Bonacorso, HG; Correa, MS; Ferreira, J; Oliveira, SM; Otuki, MF; Paim, GR; Prudente, AS; Silva, CR; Wentz, AP, 2014) |
| "Severe pain is a common symptom of sickle cell disease (SCD)." | ( Abrahamson, K; Molter, BL, 2015) |
| "Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception." | ( Huang, Y; Lei, W; Lu, B; Sun, J; Xiao, C; Yao, J; Zhang, H, 2014) |
| "Pain is an important health issue that not only negatively affects the HRQOL but also results in fatigue, dyspnea, disturbed sleep, and financial difficulties in cancer patients." | ( Hara, T; Kido, T; Takahashi, M; Yokoyama, T, 2014) |
| "Pain is a common symptom in patients with multiple myeloma (MM)." | ( Ahmedzai, SH; Boland, J; Chopra, L; Engels, Y; Ezaydi, Y; Foster, A; Gethin, A; Green, T; Sloot, S; Snowden, JA; Verhagen, S; Vissers, K, 2015) |
| "Cancer pain is complex, and despite the introduction of the WHO cancer pain ladder, few studies have looked at the prevalence of adjuvant medication use in an inpatient palliative medicine unit." | ( Davis, MP; Gordon, P; Gross, J; Sharma, P; Shinde, S, 2015) |
| "Pain is recognized as a public health problem in the United States, affecting millions of people of all ages (Committee on Advancing Pain Research, Care, and Education Board on Health Sciences Policy, 2011)." | ( Ward, CW, 2015) |
| "Pain is a common occurrence in the oncology population." | ( Faley, B; Gonzalez, R; Howlett, C; Yerram, P, 2016) |
| "Pain is very common in patients with cancer." | ( Bell, RF; Derry, S; Jackson, KC; Strassels, S; Straube, C; Straube, S; Wiffen, PJ, 2014) |
| "Pain is believed to be undertreated in patients with dementia; however, no larger studies have been conducted." | ( Astrup, A; Gasse, C; Jensen-Dahm, C; Mortensen, PB; Waldemar, G, 2015) |
| "Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional." | ( Delgado Rodrigues, RN; Goulart, LI; Prieto Peres, MF, 2014) |
| "Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning." | ( Navratilova, E; Porreca, F, 2014) |
| "Pain is a major issue for people with many different types of wounds, in particular those people with burn injuries." | ( Cleland, H; Danilla, S; Mahar, PD; McGuinness, SK; Spinks, A; Tan, HB; Wasiak, J, 2014) |
| "Pain is the presenting symptom in 20 to 30% of patients with autosomal dominant polycystic kidney disease (ADPKD) and occurs in 50 to 60% of patients at some stage of the disease process, but its frequency increases with age and size of the cysts." | ( Santoro, D; Satta, E, 2014) |
| "Pain is a major problem in all cancer stages." | ( Besse, K; Engels, Y; te Boveldt, N; Vernooij-Dassen, M; Vissers, K, 2015) |
| "Low-back pain is very frequent, especially in active adult population." | ( Massari, L; Osti, R; Pari, C; Salvatori, G, 2015) |
| "Pain is the most common reason a patient sees a physician." | ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| "However, pain is a major side-effect of this therapy." | ( Graf, B; Gruber, M; Hansen, E; Heinlin, J; Horner, C; Karrer, S; Kerscher, C; Klein, A; Koller, M; Landthaler, M; Szeimies, RM; Werner, A; Zeman, F, 2015) |
| "Pain is one of the most terrifying symptoms for cancer patients." | ( Ay, S; Bozcuk, H; Coskun, HS; Goksu, SS; Karasu, G; Ozdogan, M; Savas, B; Soydas, T; Ulukal, E; Uysal, M, 2014) |
| "Pain is the most common reason for presentation to the emergency department (ED)." | ( Marshall, B; Pretorius, A; Searle, J, 2015) |
| "Pain is commonly experienced by patients with cancer, particularly those with advanced disease." | ( Mercadante, S, 2015) |
| "Cancer pain is one of the most important symptoms of malignant disease, which has a major impact on the quality of life of cancer patients." | ( Chandrasena, C; Schug, SA, 2015) |
| "Cancer-related pain is a significant cause of morbidity in those affected by both primary and metastatic disease." | ( Mauck, WD; Moeschler, SM; Rho, RH; Rosenberg, C; Trainor, D, 2014) |
| "Neonatal pain is often undertreated." | ( Mikos, B, 2014) |
| "Since pain is often present in trauma patients, its effect on the indirect measures of hypovolemia needs to be clarified." | ( Hagen, OA; Hisdal, J; Hoff, IE; Høiseth, LØ; Kirkebøen, KA; Landsverk, SA, 2015) |
| "Moderate or severe pain is common among people with advanced cancer and other life-threatening illnesses." | ( Husain, SA; Joranson, DE; Krakauer, EL; Luong, NK; Maurer, MA; Nguyen, TH; Nguyen, TP, 2015) |
| "Pain is often underreported and poorly managed in these patients." | ( Cleeland, CS; Fallowfield, L; Öhrling, K; Patrick, DL; Qian, Y; von Moos, R; Wei, R, 2015) |
| "Pain is a common and significant symptom experienced by children with advanced malignant disease." | ( Collins, JJ; Mherekumombe, MF, 2015) |
| "Cancer pain is a major public health problem worldwide due to the strong impact on the quality of life of patients and side effects of the existing therapeutic options." | ( Alves, Rdos S; Araújo, AA; Bezerra, DP; Guimarães, AG; Menezes, Pdos P; Oliveira, MA; Quintans Júnior, LJ; Serafini, MR, 2015) |
| "Malignant bone pain is caused by stimulation of peripheral pain receptors, termed nociceptors, which reside in the localized tumor microenvironment, including the periosteal and intramedullary bone cavities." | ( Fadl-Alla, BA; Fan, TM; Lezmi, S; Pondenis, HC; Shor, S; Wycislo, KL; Zhang, X, 2015) |
| "Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood." | ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015) |
| "Bone cancer pain is a common symptom in cancer patients with bone metastases and the underlying mechanisms are largely unknown." | ( Dan, QQ; Deng, YJ; He, M; Liu, J; Liu, W; Meng, FF; Wang, TH; Wang, XY; Wei, L; Xia, QJ; Xu, Y; Zhou, FH, 2015) |
| "Thus, vocalizing in pain is not only communicative." | ( Schirmer, A; Swee, G, 2015) |
| "Pain is a distressing non-motor symptom experienced by up to 85% of people with Parkinson's disease (PD), yet it is often untreated." | ( Allen, NE; Canning, CG; Moloney, N; van Vliet, V, 2015) |
| "Pain is one of the most common and distressing symptoms in patients with cancer, with a high prevalence of 90%." | ( Cho, D; Choe, Y; Choi, J; Han, HS; Kim, J; Lee, K; Lee, KH; Lee, SC; Lim, SN; Park, M; Park, S; Ryoo, HM; Yun, J; Zang, DY, 2015) |
| "Pain is a hallmark of sickle cell disease (SCD) and its treatment remains challenging." | ( Ballas, SK; Gupta, K; Gupta, M; Msambichaka, L, 2015) |
| "Pain is a common and debilitating complication for cancer patients significantly compromising their quality of life." | ( Clausen, RP; Dickenson, AH; Falk, S; Frøsig-Jørgensen, M; Heegaard, AM; Schwab, SD, 2015) |
| "OBJECT Back and leg pain are the primary outcomes of adult spinal deformity (ASD) and predict patients' seeking of surgical management." | ( Ames, CP; Clark, AJ; Eastlack, R; Gupta, M; Hart, RA; Hostin, R; Kebaish, K; Kelly, MP; Kim, HJ; Klineberg, E; Lafage, V; Protopsaltis, TS; Rolston, JD; Scheer, JK; Schwab, F; Shaffrey, CI; Smith, JS, 2015) |
| "Pain is one of the most common and distressing symptoms suffered by patients with progression of cancer." | ( Bao, Y; Gao, Y; Hou, W; Hua, B; Kong, X; Li, C; Yang, L; Zheng, H, 2015) |
| "Chronic pain is a common complication of diabetes." | ( Byrne, FM; Chapman, V; Cheetham, S; Vickers, S, 2015) |
| "Pain is one of the most common symptoms in children and young people (CYP) with life-limiting conditions (LLCs) which include a wide range of diagnoses including cancer." | ( Beecham, E; Bluebond-Langner, M; Candy, B; Howard, R; Jones, L; Laddie, J; McCulloch, R; Rees, H; Vickerstaff, V, 2015) |
| "Pain is the most disruptive influence on the quality of prognosis among head and neck squamous cell carcinoma (HNSCC) patients." | ( Chen, Z; Hu, R; Huang, Y; Jiang, H; Jiang, J; Xu, H; Yan, J; Yang, Y; Zhang, Y, 2015) |
| "Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus." | ( Abzianidze, EB; Gartsukaia, GP; Nebieridze, MI; Nozadze, IR; Tsagareli, MG; Tsiklauri, ND, 2015) |
| "Neuropathic pain is common in peripheral nerve injury and often fails to respond to ordinary medication." | ( Alberch, J; Boadas-Vaello, P; Puig, T; Turrado, C; Verdú, E; Vidal-Sancho, L; Xifró, X, 2015) |
| "Pain is a syndrome of various clinical disorders, which arises from various pathological conditions and which presents significant challenges in both its diagnosis and treatment." | ( Jakubowska, A; Kulig, K; Sałat, K, 2015) |
| "Cancer pain is a multidimensional symptom for which opioids are the mainstay of treatment." | ( Bruera, E; Chisholm, G; Hui, D; Kwon, JH; Liu, D; Park, JC; Seo, L; Tanco, K; Williams, J; Wong, A, 2015) |
| "Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway." | ( Arakawa, N; Fields, HL; Meske, D; Morimura, K; Navratilova, E; Okun, A; Ossipov, M; Porreca, F; Qu, C; Xie, JY, 2015) |
| "Cancer-induced bone pain is described as dull, aching ongoing pain." | ( King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY, 2015) |
| "Pain is a hallmark of almost all bodily ailments and can be modulated by agents, including analgesics and anesthetics that suppress pain signals in the central nervous system." | ( Agrawal, DK; Hambsch, ZJ; Kerfeld, MJ; Kirkpatrick, DR; McEntire, DM; Reisbig, MD; Smith, TA; Youngblood, CF, 2015) |
| "Chronic pain is managed mostly by the daily administration of analgesics." | ( Alexa, T; Marza, A; Tamba, B; Voloseniuc, T, 2015) |
| "Severe pain is associated with a decreased quality of life in patients with cancer." | ( Bennett, MI; Min, S; Peng, L; Wei, K; Zejun, Z, 2015) |
| "The experience of pain is associated with reactivity of both the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis." | ( Kaess, M; Koenig, J; Rinnewitz, L; Warth, M, 2015) |
| "Pre-surgical pain is very disabling and is viewed as biological." | ( Barrett, E; Gallagher, S; Leov, J; Swain, N, 2017) |
| "Post-obturation pain is frustrating to both patients and dentists." | ( Chu, CH; Li, SK; Wong, AW; Zhang, C; Zhang, S; Zhu, X, 2015) |
| "Neuropathic pain is a debilitating condition in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)." | ( Apostolopoulos, V; Duffy, SS; Fivelman, B; Lees, JG; Makker, PG; Moalem-Taylor, G; Perera, CJ, 2015) |
| "Pain is an important and distressing symptom in Parkinson's disease (PD)." | ( Benetin, J; Hanakova, M; Harsany, J; Martinkova, J; Minar, M; Singliarova, H; Valkovic, P, 2015) |
| "Arthritis pain is an important healthcare issue with significant emotional and affective consequences." | ( Ji, G; Neugebauer, V; Thompson, JM, 2015) |
| "The experience of pain is a highly complex and personal experience, characterized by tremendous inter-individual variability." | ( Khan, HS; Stroman, PW, 2015) |
| "Pain is also associated with depression of many behaviors, and drug effects can differ in assays of pain-stimulated versus pain-depressed behavior." | ( Carroll, FI; Freitas, KC; Negus, SS, 2015) |
| "Chronic muscle pain is a significant health problem leading to disability[1]." | ( Gregory, NS; Sluka, KA; Whitley, PE, 2015) |
| "Leg pain is a common condition in athletes as well as in the general population, and has a broad differential diagnosis that includes musculoskeletal, vascular, rheumatologic, and neurologic etiologies." | ( Howe, BM; Lueders, DR; Sellon, JL, 2016) |
| "Dealing with pain is one of the most important issues of medicine." | ( Akkar, OB; Cetin, A; Cetin, M; Gulturk, S; Kula, A, 2016) |
| "On the other hand, pain is a multidimensional experience with sensory-discriminative and motivational-affective components." | ( Hamada, Y; Igarashi, K; Ikegami, D; Kuzumaki, N; Narita, M; Tamura, H; Watanabe, M, 2015) |
| "Pain is the most common complication of orthodontic treatment." | ( Chiniforush, N; Khatami, M; Rakhshan, V; Shariati, M; Sobouti, F, 2015) |
| "Postpartum pain is a frequent condition that negatively affects women's quality of life, interferring with everyday life." | ( Bounous, VE; Costantino, D; Costantino, M; Guaraldi, C, 2015) |
| "Pain is a common non-motor symptom of Parkinson's disease." | ( Chaudhuri, KR; DeCesare, J; Ehret, R; Hopp, M; Krygowska-Wajs, A; Lomax, M; Marti, MJ; Martinez-Martin, P; Oksche, A; Rascol, O; Reimer, K; Sátori, M; Trenkwalder, C; Vališ, M, 2015) |
| "Itch and pain are unpleasant sensations that distress many patients with disease." | ( Chen, L; Dong, Z; Han, H; Tan, T; Wang, W, 2016) |
| "Animal pain is defined by a series of expectations or criteria, one of which is that there should be a physiological stress response associated with noxious stimuli." | ( Adams, L; Elwood, RW, 2015) |
| "Severe pain is a major problem for cancer patients, and pain management often requires the use of opioids." | ( Irawan, C; Setiabudy, R; Sudoyo, AW, 2015) |
| "Pain is a prevalent, and due to the ageing population, increasing medical problem." | ( Nguyen, V; Pergolizzi, JV; Raffa, RB; Taylor, R, 2015) |
| "Pain is a clinical challenge to health care providers who care for hand disorders." | ( Curtin, C, 2016) |
| "Exertional leg pain is a common condition seen in runners and the general population." | ( Finnoff, JT; Rajasekaran, S, 2016) |
| "Pain is the most common cause of failure of outpatient hysteroscopy." | ( Haggag, H; Hassan, A; Wahba, A, 2016) |
| "Pain is common in the elderly population and its prevalence varies according to the studied disease, clinical setting, sex and age." | ( Berglund, J; Rennemark, M; Wranker, LS, 2016) |
| "Pain is common among older adults and there are significant differences between the sexes." | ( Berglund, J; Rennemark, M; Wranker, LS, 2016) |
| "Still nowadays pain is one of the most common disabling conditions and yet it remains too often unsolved." | ( Aricò, G; Parenti, C; Pasquinucci, L; Ronsisvalle, G; Turnaturi, R, 2016) |
| "Pain is an important protective system that alerts organisms to actual or possible tissue damage." | ( Sakai, A; Suzuki, H, 2015) |
| "Lipid-induced pain is also significantly reduced in ASIC3 knockout mice." | ( Breuil, V; Christin, M; Cognard, C; Delaunay, A; Deval, E; Euller-Ziegler, L; Ferreira, T; Ferru-Clément, R; Friend, V; Lingueglia, E; Marra, S; Noel, J; Roux, C; Sebille, S, 2016) |
| "Pain is a hallmark feature of sickle cell disease (SCD)." | ( Gupta, K; Gupta, M; Jahagirdar, B; Lamarre, Y; Mittal, A, 2016) |
| "Pain is controllable, and patients have a right to not experience pain." | ( Dong, Y; Jiang, F; Yu, J; Zhang, B; Zhang, X; Zhou, T; Zhuang, F, 2016) |
| "Pain is best assessed by self-reporting pain scales; but in patients who are unable to communicate, behavioral pain scales seem to have benefit." | ( Stephens, J; Wright, M, 2016) |
| "Chronic spontaneous pain is a clinically relevant non-motor symptom in multiple system atrophy (MSA) and Parkinson's disease (PD)." | ( Eggert, K; Lefaucheur, JP; Möller, JC; Mylius, V; Oertel, WH; Pape, H; Pee, S; Stamelou, M; Teepker, M, 2016) |
| "Pain is a significant public health concern, and current pharmacological treatments have problematic side effects and limited effectiveness." | ( Hillhouse, TM; Negus, SS, 2016) |
| "Pain is a common and highly distressing symptom in pediatric patients with advanced malignancies." | ( Anghelescu, DL; Baker, JN; Ehrentraut, JH; Snaman, JM, 2016) |
| "Pain is common in men undergoing rigid cystoscopy." | ( Du, GZ; Hu, AM; Liu, J; Qiu, Y, 2016) |
| "Pain is sensed, transmitted, and modified by a variety of mediators and receptors." | ( Endo, Y; Fujita, T; Fukumoto, S; Hagiwara, Y; Mizoguchi, H; Sakurada, S; Shima, K; Sugawara, S; Tadano, T; Takahashi, M; Tsuchiya, M; Watanabe, M, 2016) |
| "Pain is an elemental inducer of avoidance." | ( Dayan, P; Dolan, RJ; Eldar, E; Hauser, TU, 2016) |
| "Pain is a frequent symptom among patients in the hospital." | ( Binswanger, IA; Calcaterra, SL; Doyle, R; Drabkin, AD; Frank, JW; Koester, S; Leslie, SE; Reich, JA, 2016) |
| "Addressing pain is a crucial aspect of emergency medicine." | ( Burton, JH; Donato, M; Echternach, JM; Hoppe, JA; Rodgers, JM, 2016) |
| "Chronic pain is one of the most common non-motor symptoms of Parkinson's disease (PD) affecting up to 85% of patients." | ( Gee, LE; Pilitsis, JG; Ramirez-Zamora, A; Shin, DS; Walling, I, 2016) |
| "Injection pain is a frequent and unpleasant side effect of numerous drugs in clinical use, and previous reports have indicated that the ligand gated ion channels transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) can mediate this effect on sensory neurons." | ( Eberhardt, E; Eberhardt, M; Leffler, A; Schillers, F, 2016) |
| "More severe pain is managed with opioids." | ( Ackermann, RJ; Scheetz, A, 2016) |
| "Fear of dental pain is a major barrier to treatment for children who need dental care." | ( Anand, P; Ashley, PF; MacDonald, LC; Moles, DR; Parekh, S, 2016) |
| "Post-procedural pain is frequent after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), and is only partially prevented by treatment selectivity." | ( Allaham, W; Benzakoun, J; Garcia Alba, C; Lagadec, M; Ronot, M; Sibert, A; Vilgrain, V, 2017) |
| "Pain is a serious health problem that impacts the lives of many individuals." | ( Barbosa, C; Cummins, TR, 2016) |
| "Pain is a complex experience involving sensory and affective components." | ( Amano, T; Hara, T; Ide, S; Kaneda, K; Kaneko, T; Minami, M; Ohno, A; Takahashi, D; Yoshioka, M, 2016) |
| "Cancer pain is an important and distressing symptom that tends to increase in frequency and intensity as the cancer advances." | ( Bao, YJ; Hou, W; Hua, BJ; Knaggs, R; Kong, XY; Xia, J; Yang, L, 2016) |
| "Pain is a disease by itself and it's a public health concern of major implication in children, not just because of the emotional component of the child and his family, but also due to the potential morbidity and mortality involving it." | ( Castillo, T; Rodríguez, MC; Villamor, P, 2016) |
| "Pain is often cited as one of the worst features of medical abortion." | ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "Although pain is one of the most common side effects encountered with medical abortion, little is known about optimal pain management for this process." | ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly." | ( Akassoglou, K; Andreska, T; Barde, S; Eriksson, LI; Harkany, T; Hökfelt, TG; Lei, B; Mathew, JP; Terrando, N; Yang, T; Zhang, MD, 2016) |
| "Inflammatory pain is thought to arise from increased transmission from nociceptors and recruitment of 'silent' afferents." | ( Davis, BM; DeBerry, JJ; Saloman, JL; Smith-Edwards, KM; Woodbury, CJ, 2016) |
| "Pain is the most common complaint in the emergency department (ED), and emergency physicians face unique challenges in making opioid-related treatment decisions." | ( Khidir, H; Weiner, SG, 2016) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| "Kidney pain is a common complication in patients with autosomal dominant polycystic kidney disease (ADPKD), and data from the TEMPO 3:4 trial suggested that tolvaptan, a vasopressin V2 receptor antagonist, may have a positive effect on kidney pain in this patient group." | ( Blais, JD; Casteleijn, NF; Chapman, AB; Czerwiec, FS; Devuyst, O; Gansevoort, RT; Higashihara, E; Leliveld, AM; Ouyang, J; Perrone, RD; Torres, VE, 2017) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Pain is necessary to alert us to actual or potential tissue damage." | ( Altruda, F; Bartsch, S; Castori, M; Chiabrando, D; Di Capua, M; di Rocco, M; Gießelmann, S; Grammatico, P; Hübner, CA; Kurth, I; Madeo, A; Silengo, L; Tolosano, E; Ungelenk, M, 2016) |
| "Pain is a significant side effect of disease, surgery and treatments including chemotherapy." | ( Bennett, M, 2016) |
| "Ear pain is central to children's and parents' experience of the illness." | ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016) |
| "We argue that pain is associated with EEG frontal synchrony and caudal asynchrony, leading to the disruption of cortico-cortical connectivity." | ( Choo, HJ; LeBlanc, BW; Levitt, J; Saab, CY; Smith, KA, 2017) |
| "Chronic pain is treated most commonly with opioid analgesics, anti-inflammatory steroids and nonsteroidal anti-inflammatory drugs." | ( Fischer, BD, 2017) |
| "Pain is associated with several conditions, such as inflammation, that result from altered peripheral nerve properties." | ( Hsieh, CL; Huang, CP; Liao, HY; Lin, YW, 2017) |
| "Pain is a common side effect of orthodontic treatment." | ( Atack, NE; Bradley, R; Deacon, S; Ellis, P; Ewings, P; Griffiths, H; House, K; Ireland, AJ; Jordan, A; Moore, MB; Sandy, JR; Scaysbrook, E; Wenger, N; Williams, JC; Worth, V, 2017) |
| "Chronic back pain is one of the most important complications of postmenopausal osteoporosis." | ( Iino, T; Kato, S; Naito, Y; Nakagawa, T; Sudo, A; Wakabayashi, H, 2017) |
| "Cancer pain is difficult to manage in advanced cancer, especially when delirium is present; however, misinterpretation of delirium symptoms as pain cues may inflate pain judgments." | ( Chan, VWS; Gagliese, L; Mah, K; Rodin, RA; Stevens, BJ; Zimmermann, C, 2017) |
| "Pain is fundamentally unpleasant and induces a negative affective state." | ( Almoosawi, N; Engblom, D; Frisch, I; Fritz, M; Jaarola, M; Klawonn, AM; Mirrasekhian, E; Singh, AK; Zajdel, J, 2017) |
| "Pain is the most frequent complaint of burn-injured patients." | ( Eitan, S; Emery, MA; Shawn Bates, ML; Wellman, PJ, 2017) |
| "Pain is a common complaint among postmenopausal women." | ( Evans, HM; Howe, PRC; Wong, RHX, 2017) |
| "Musculoskeletal pain is the most common type of pain in patients with PD." | ( Fu, YT; Huang, JY; Li, J; Liu, CF; Liu, JY; Ma, LJ; Mao, CJ; Wang, Y; Zhang, HJ, 2018) |
| "Pain is one of the most commonly reported symptoms in people living with HIV/AIDS, whether or not they are receiving anti-retroviral therapy." | ( Jelsma, J; Parker, R; Stein, DJ, 2017) |
| "Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time." | ( Coluzzi, F; Fornasari, D; Pergolizzi, J; Romualdi, P, 2017) |
| "Patients with pain are at higher risk of suicide." | ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017) |
| "Pain is a subjective and complex phenomenon." | ( Reddan, MC; Wager, TD, 2018) |
| "Pain is one of the most frequent symptoms in patients with advanced chronic illnesses." | ( Jespersen, BA; Neergaard, MA, 2017) |
| "Pain is a common and distressing symptom of pediatric cancer, as reported by both children and their parents." | ( Barwick, M; Campbell, F; Chambers, CT; Fernandez, CV; Irwin, K; Jibb, LA; Nathan, PC; Parker, JA; Stinson, JN; Tutelman, PR; Witteman, HO, 2018) |
| "Pain is a severe and debilitating complication of metastatic bone cancer." | ( Andersen, L; Appel, CK; Blancheflor Kristensen, S; Ding, M; Falk, S; Gabel-Jensen, C; Gallego-Pedersen, S; Heegaard, AM; Sayilekshmy, M, 2017) |
| "Knee pain is one of the most common symptoms of knee osteoarthritis (OA) that affects the quality of life in the older adults, and identifying the contributing factors of knee pain is important." | ( Chang, CB; Han, HS; Lee, DC; Lee, JY, 2017) |
| "Treat the Pain is supporting governments in Sub-Saharan Africa to reduce needless suffering and improve access to essential pain medicines for patients in pain by supporting the expansion of locally produced, affordable oral morphine solution and expanding basic training in pain assessment and management." | ( O'Brien, M; Plattner, L; Schwartz, A, 2018) |
| "Pain is a frequent non-motor feature in Parkinsonism but mechanistic data on the alteration of pain processing are insufficient to understand the possible causes and to define specifically-targeted treatments." | ( Avenali, M; De Icco, R; Fresia, M; Pacchetti, C; Perrotta, A; Sandrini, G; Serrao, M; Tassorelli, C, 2017) |
| "Pain is an efficient outcome measure for predicting broader patient response in osteoarthritis." | ( Chen, WJ; Gates, DF; Lin, HY; Moore, RA; Peloso, PM; Popmihajlov, Z; Straus, WL, 2016) |
| "Pain is a defense mechanism of the body that entails physiological, anatomical, neurochemical, and psychological changes, and is defined as an unpleasant sensory and emotional experience with potential risk of tissue damage, comprising the leading cause of appointments with Physicians worldwide." | ( Alfaro-Rodríguez, A; Bandala, C; Carrillo-Mora, P; Cortes-Altamirano, JL; Jaime, HB; Olmos-Hernandez, A; Reyes-Long, S, 2018) |
| "Pain is often associated with a more rapid progression of cognitive and functional decline, and behavioral disturbance in dementia." | ( Han, SH; Kim, YS; Lee, J; Moon, Y, 2017) |
| "Neuropathic pain is the most severe and resistant type of pain which has impact on quality of life and behaviour; it most commonly occurs at night causing disturbed sleep." | ( Jawed, I; Kamil, A; Khan, MI; Mahmood, I; Mahmood, R; Sayeed, BZ; Sayeed, FZ; Tariq, T, 2017) |
| "As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs." | ( Molden, E; Solhaug, V, 2017) |
| "Pain is a complex experience with both sensory and affective components." | ( Deyama, S; Ide, S; Kaneda, K; Maruyama, C; Minami, M; Nagano, Y; Yoshioka, M, 2018) |
| "Chronic pain is a major global public health issue causing a severe impact on both the quality of life for sufferers and the wider economy." | ( Aloisi, AM; Bachiocco, V; Bennett, DLH; Bogdanov, YD; Bras, JT; Cox, JJ; Emery, EC; Follenfant, M; Gossage, SJ; Gras, M; Habib, AM; Houlden, H; Humphrey, J; Kolesnikov, A; Komine, Y; Le Cann, K; Li, S; Maniatis, N; Marsili, L; Matsuyama, A; Minett, MS; Okorokov, AL; Panov, KI; Pereira, V; Ponsolles, C; Ramirez, JD; Santana-Varela, S; Sikandar, S; Torres, JM; Wood, JN; Yamamori, T; Yamaoka, K; Zhao, J, 2018) |
| "Trochlear pain is frequently overlooked as published data regarding the clinical characteristic and current treatment are limited." | ( Chanlalit, W; Soodchuen, S; Teeyapant, C, 2018) |
| "Pain is a widely neglected symptom in patients with amyotrophic lateral sclerosis (ALS), even though it may be common and have a significant impact on the quality of life." | ( Aono, H; Hanamitsu, H; Hatta, H; Hirutani, M; Hongo, S; Ishida, N; Kumano, A; Suzuki, R; Takahashi, M; Tuigi, M; Wakasugi, E; Yamamoto, Y; Yamatani, A; Zakoji, N, 2018) |
| "Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage." | ( Gómez, KV; Majdalani, A; Pigliapoco, V; Santos Chocler, G; Yazde Puleio, ML, 2018) |
| "Pain is mediated by primary sensory neurons (nociceptors) that can respond to a variety of thermal, mechanical and chemical signals." | ( Christensen, AD; Cook, AD; Hamilton, JA; McMahon, SB; Tewari, D, 2018) |
| "Pain is a very complex biochemical and electrical process involving sensory part, nerve transmission, and brain perception of pain." | ( Cosic, D; Cosic, I, 2017) |
| "Pain is one of the most common and troublesome non-motor symptoms of Parkinson's disease (PD)." | ( Abbruzzese, G; Antonini, A; Berardelli, A; Chaudhuri, KR; Defazio, G; Ferreira, J; Martinez-Martin, P; Rascol, O; Tinazzi, M; Trenkwalder, C, 2018) |
| "Hunger and pain are two competing signals that individuals must resolve to ensure survival." | ( Alhadeff, AL; Betley, JN; De Jonghe, BC; Guo, C; Hantman, AW; Hernandez, E; Holland, RA; Klima, ML; Phillips, SZ; Su, Z, 2018) |
| "Pain is one of the most prevalent, costly and disabling conditions that reduces quality of life." | ( Anversa, RG; Birmann, PT; Bruning, CA; Lenardão, EJ; Lima, DB; Savegnago, L; Sousa, FSS, 2018) |
| "Pain is one of the common and debilitating health manifestations associated with the majority of diseased conditions, thus making it a serious health concern worldwide." | ( Dhillon, H; Singh, S, 2018) |
| "Although pain is one of the most common afflictions, it is often inadequately managed because the available analgesic options are relatively limited due to insufficient efficacy, unacceptable adverse effects or the potential for misuse or abuse." | ( Ossipov, MH; Pergolizzi, JV; Raffa, RB; Taylor, R, 2018) |
| "Pain is complex, difficult to understand and diagnose, and especially enigmatic to manage." | ( Atkinson, TJ; Bryant, C; Crumb, MW, 2018) |
| "Significant pain is common in patients hospitalized in an internal medicine department, but the pain is mostly short term and pain control is adequate despite the restricted use of opioid therapy during hospitalization." | ( Froom, P; Shimoni, Z; Varon, D, 2018) |
| "Inflammatory pain is a complex and multifactorial disorder." | ( Bouali-Benazzouz, R; Favereaux, A; Landry, M; Tell, G; Zaky, A, 2018) |
| "Pain is the leading reason for seeking health care, and mu opioid receptor agonists continue to be prescribed despite well-documented adverse effects." | ( France, CP; Lu, HY; Minervini, V; Osteicoechea, DC; Padarti, J, 2018) |
| "Pain is a global public health problem because the burden of acute and chronic pain is considerable and is continuously increasing." | ( Jukić, M; Puljak, L, 2018) |
| "Itch and pain are refractory symptoms of many ocular conditions." | ( Davidson, S; Duan, B; Guo, C; Huang, AJW; Huang, CC; Huang, T; Jiang, H; Li, F; Liu, Q; Xiao, M; Yang, W; Yu, G, 2018) |
| "Pain is a prevalent and debilitating symptom of multiple sclerosis (MS); yet, the mechanisms underlying this pain are unknown." | ( Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Oh, J; Osborne, NR; Rogachov, A, 2018) |
| "Pain is prevalent in cancer patients, appearing to be moderate to severe in more than one third of them." | ( Galanos, A; Mystakidou, K; Panagiotou, I; Roumeliotou, A; Symeonidi, M; Tsilika, E, 2018) |
| "Leg pains are more frequent in those with CHD compared with their healthy siblings." | ( Chaudhry, B; Coats, L; Crossland, DS; Hutchinson, S, 2018) |
| "Pain is a common experience for most patients in the intensive care unit (ICU)." | ( Dehcheshmeh, HS; Johnston, TP; Joneidi-Jafari, N; Mojtahedzadeh, M; Panahi, Y; Sahebkar, A, 2018) |
| "Abdominal pain is a relatively common complaint during pregnancy, and a methodical approach should be taken when evaluating LUQ in pregnancy." | ( Chin, JM; Schlueter, RJ; Wong, JW, 2018) |
| "Experiences of pain are not associated with decisions about whether or not to use cannabis." | ( Baruch, YB; Gelkopf, M; Greene, T; Sznitman, S, 2018) |
| "Pain is a highly prevalent problem in older adults and dying patients." | ( Janssen, DJA; Martens, MJM; Schols, JMGA; van den Beuken-van Everdingen, MHJ, 2018) |
| "Pain is the most common complaint for an emergency department (ED) visit, but ED pain management is poor." | ( Aitken, A; Duncan, R; Haase, D; Jones, K; Nguyen, T; Rea, J; Rubinson, L; Tiffany, L; Tran, QK; Tuteja, G, 2018) |
| "Pain is associated with negative emotions such as anxiety, but the underlying neurocircuitry and modulators of the association of pain and anxiety remain unclear." | ( Bouali-Benazzouz, R; Covita, J; Egron, K; Favereaux, A; Fossat, P; Gundlach, AL; Landry, M; López-González, MJ; Ma, S; Roca-Lapirot, O; Trigilio, G, 2019) |
| "Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment." | ( Baudouin, C; Ben-Dhaou, C; Melik Parsadaniantz, S; Ouimet, T; Poras, H; Reaux-Le Goazigo, A; Wurm, M, 2019) |
| "Also, although pain is difficult to assess in this group, the impact on QoL is probably considerable." | ( Achterberg, WP; Caljouw, MAA; Gussekloo, J; Husebo, BS; van Dam, PH, 2018) |
| "Pain is a significant public health problem that needs policy at the national and local level to resolve incidents of insufficient, ineffective, and disparate pain treatment while limiting the risk of inadvertently increasing the use of treatment such as opioids that can result in public harm." | ( Gordon, DB; Gross, J, 2019) |
| "Chronic pain is a massive socieoeconomic burden and is often refractory to treatment." | ( Borgland, SL; Huang, S; Zamponi, GW, 2019) |
| "This severe pain is mostly refractory to palliative analgesic treatment, and the latter was only detected by specific and sensitive outcomes." | ( Beauchamp, G; Blair, J; de Lorimier, LP; Lussier, B; Monteiro, BP; Moreau, M; Pelletier, JP; Troncy, E, 2018) |
| "Nipple pain is the second most common reason for early weaning, exceeded only by the insufficient milk supply." | ( Bolognesi, LFC; Borges, FA; de Barros, NR; Dos Santos, RS; Herculano, RD; Marques, RFC; Miranda, MCR; Norberto, AMQ; Schiavon, JV, 2019) |
| "Pain is a common symptom among patients with cancer, yet pain prevalence and management in older cancer pts." | ( Ahcene-Djaballah, S; Brunello, A; Dadduzio, V; Fiduccia, P; Guglieri, I; Lettiero, A; Lonardi, S; Maruzzo, M; Schiavon, S; Tierno, G; Zagonel, V, 2019) |
| "Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target." | ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019) |
| "Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control." | ( Largent-Milnes, TM; Thompson, AL; Vanderah, TW, 2019) |
| "Prehospital acute pain is a frequent symptom that is often inadequately managed." | ( Christensen, EF; Friesgaard, KD; Giebner, M; Kirkegaard, H; Nikolajsen, L; Rasmussen, CH, 2019) |
| "Chronic pain is a major clinical problem with limited treatment options." | ( Hu, L; Hu, XF; Li, HP; Li, M; Lin, LX; Liu, WT; Pan, HL; Shu, Y; Xiang, HC; Zhang, RY; Zhao, YL; Zhu, H, 2019) |
| "Pain is reported as the most bothersome nonmotor symptom in PD; however, pain remains overlooked and poorly understood." | ( Berzuino, MB; Campos, ACP; Domenici, RA; Fonoff, ET; Hernandes, MS; Maciel, ST; Pagano, RL, 2019) |
| "Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction." | ( Andreassen, KV; Dąbrowska, A; Ding, M; Henriksen, K; Karsdal, MA; Katri, A; Löfvall, H; Thudium, CS, 2019) |
| "Pain is the main cause of disability from arthritis." | ( Blanshan, N; Dorman, C; Frizelle, S; Krug, HE; Mahowald, M, 2019) |
| "Burn pain is one of the worst imaginable pain, associated with considerable morbidity and mortality worldwide." | ( Ali, H; Khalid, S; Khan, A; Khan, S; Kim, YS; Shal, B, 2019) |
| "Pain is an unpleasant side-effect that can be experienced during orthodontic procedures including debonding of fixed appliances." | ( Alharbi, F; Almuzian, M; Alomari, S; Mohammed, H; Rizk, MZ; Ulhaq, A, 2019) |
| "Arthritis pain is heterogeneous - there are trajectories of people whose pain gets better or worse." | ( Ferguson, E; James, RJE; Walsh, DA, 2019) |
| "Chronic pain is commonly accompanied with anxiety disorder, which complicates treatment." | ( Guan, SY; Hu, LN; Liu, A; Liu, SB; Lu, L; Tian, Z; Wang, XS; Yang, LK; Yue, J; Zhang, K; Zhao, MG, 2019) |
| "Mild pain is usually managed quite well with oral acetaminophen or ibuprofen." | ( Harirforoosh, S; Odle, BL; Thigpen, JC, 2019) |
| "Pain is the most ubiquitous and costly disease in society and yet all of our "treatments" have toxicities, especially for prolonged use." | ( Hruby, VJ, 2019) |
| "Pain is a common nonmotor symptom of Parkinson's disease (PD) that remains neglected and misunderstood." | ( Berzuino, MB; Campos, ACP; Fonoff, ET; Hernandes, MS; Pagano, RL, 2019) |
| "Pain is a common complaint among the aging population, particularly among the older residents of nursing homes." | ( Biglarian, A; Foroughan, M; Jafari, Z; Rashedi, V; Shahboulaghi, FM, 2019) |
| "Chronic pain is common among older residents of nursing homes and deteriorates their quality of life." | ( Biglarian, A; Foroughan, M; Jafari, Z; Rashedi, V; Shahboulaghi, FM, 2019) |
| "Pain is a core complaint among rheumatoid arthritis (RA) patients, and persistent pain requires treatment adjustments according to current strategies." | ( Arce-Salinas, CA; Espinosa-Ortega, HF; Ruiz-Medrano, E, 2019) |
| "Pain is a major symptom of patients visiting the emergency department (ED), with up to 42% of ED visits being related to pain (2)." | ( Rui, P; Schappert, SM, 2019) |
| "The way pain is remembered seems to depend on certain factors, including the type of pain or, in other words, its cause, the context, and the meaning it has for the person suffering from it." | ( Bąbel, P; Farley, D; Piszczek, Ł, 2019) |
| "Pain is a natural bioassay for detecting and quantifying biological activities of venoms." | ( Schmidt, JO, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "Chronic pain is a worldwide major health problem and many pain-suffering patients are under opioid based therapy." | ( Agustín-Pavón, C; Campos-Jurado, Y; Granero, L; Hipólito, L; Igual-López, M; Padilla, F; Polache, A; Zornoza, T, 2019) |
| "Chronic pain is associated with altered affective state, stress, anxiety and depression." | ( Abelson, KS; Brønnum Pedersen, T; Hestehave, S; Munro, G, 2019) |
| "Pain is by far the most common diagnosis in cannabis drugs." | ( Broich, K; Cremer-Schaeffer, P; Schmidt-Wolf, G, 2019) |
| "Chronic pain is the most common indication, as health claims data and the accompanying survey show." | ( Gastmeier, K; Häuser, W; Karst, M; Petzke, F; Radbruch, L; Steffen, E, 2019) |
| "Pain is a major primary health care problem." | ( Chen, YH; Hsu, SF; Hung, SY; Lin, JG; Lin, PL; Luo, ST; MacDonald, I; Yang, CT, 2019) |
| "Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients." | ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020) |
| "Pain is a common distressing symptom in children receiving pediatric palliative care." | ( Friedrichsdorf, SJ; Postier, AC, 2019) |
| "Knee pain is often underreported, underestimated and undertreated." | ( Abbas, AA; Chan, CK; Chin, AV; Cumming, RG; Hairi, NN; Jaafar, MH; Kamaruzzaman, SB; Mat, S; Ng, CT; Othman, S; Raja, J; Sockalingam, S; Tan, MP; Tey, NP, 2019) |
| "Neuropathic pain is a chronic pain caused by central and peripheral nerve injury, long-term diabetes or treatment with chemotherapy drugs, and it is dissimilar to other chronic pain conditions." | ( Bán, EG; Brassai, A; Vizi, ES, 2020) |
| "Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear." | ( Cao, X; Cao, Y; Chen, H; Crane, JL; Demehri, S; Deng, R; Dong, X; Guan, Y; Hu, B; Hu, J; Jain, A; Li, Y; Ling, Z; Lu, H; Lyu, X; Ni, S; Pan, D; Qi, H; Skolasky, R; Wan, M; Wang, X; Wu, P; Wu, T; Zhen, G; Zou, X, 2019) |
| "Arthritic pain is the main unpleasant component of rheumatoid arthritis." | ( Anselmo-Franci, JA; Branco, LGS; Carolino, ROG; Mota, CMD; Rodrigues-Santos, C, 2020) |
| "Burn injury pain is a significant public health problem." | ( Eitan, S; Emery, MA, 2020) |
| "These shifts in pain care have led to new pain management strategies that rely on multidisciplinary teams and nonpharmacologic pain treatments." | ( Brummett, B; Higgins, DM; Holtzheimer, P; Martino, S; Mattocks, K; Ngo, T; Reznik, TE; Rosen, MI; Sellinger, J; Semiatin, AM; Stapley, T, 2020) |
| "Pain is a non-motor symptom in Parkinson's disease (PD) which commonly goes underreported." | ( Bruno, V; Farcy, N; Karnik, V; Zamorano, C, 2020) |
| "Although pain is the cardinal symptom of arthritis, which is directly related to function and quality of life, the elucidation of the mechanism underlying the pathogenesis of pain in arthritis has lagged behind other areas, such as inflammation control and regulation of autoimmunity." | ( Hong, JI; Kim, HA; Park, IY, 2020) |
| "pain is one of the most often symptoms experienced by patients with advanced or chronic diseases which can cause a decrease in the quality of life of palliative patients." | ( Abdullah, V; Adli, M; Agung, RA; Elita, D; Irawan, C; Putranto, R; Shatri, H, 2019) |
| "Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN) is the most important mediating mechanism." | ( Cunha, FQ; Cunha, TM; Gomes, FIF, 2020) |
| "However, cancer pain is gradually alleviated about two weeks after radiotherapy." | ( Wang, Y; Xing, L, 2020) |
| "As ongoing pain is one of the main pain symptoms of patients, an animal model that illuminates this problem is highly anticipated." | ( De Clercq, K; Luyten, K; Persoons, E; Pinto, SJPC; Tomassetti, C; Van Bree, R; Van den Eynde, C; Voets, T; Vriens, J, 2020) |
| "Since cancer pain is caused by both tumor and chemotherapy, we assessed the efficacy of drugs from the WHO analgesic ladder for cancer pain relief in a paclitaxel-induced pain syndrome (P-IPS) model." | ( Brusco, I; Ferreira, J; Hausen, BDS; Moresco, RN; Oliveira, SM; Pinheiro, KV; Rigo, FK, 2020) |
| "Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated." | ( Ase, AR; Ribeiro-da-Silva, A; Séguéla, P; Sharif, B, 2020) |
| "Pain is the most common complaint and often thought to be undertreated, which can negatively influence the child's care and increase the risk of posttraumatic stress disorder." | ( Bielsky, A; Goldsmith, A; Meier, M; Moulton, S; Phillips, R; Recicar, J; Shahi, N; Shirek, G; Yaster, M; Zuk, J, 2020) |
| "However, pain is often a prominent symptom in patients with malignant and nonmalignant serious illness and providers have to be adept at balancing effective pain management and safety." | ( Curseen, KA; Grant, Q; Taj, J, 2020) |
| "Although pain is a prevalent nonmotor symptom in Parkinson's disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms." | ( Cao, JL; Gu, W; Luan, Y; Tang, D; Wu, H; Wu, Y; Xiao, C; Zhou, C, 2020) |
| "Pain is a prevalent symptom at the end of life and negatively impacts quality of life." | ( Bush, SH; Hagarty, AM; Lapenskie, J; Talarico, R; Tanuseputro, P, 2020) |
| "Severe pain is defined using a validated pain scale combining pain frequency and intensity: daily pain of severe intensity." | ( Bush, SH; Hagarty, AM; Lapenskie, J; Talarico, R; Tanuseputro, P, 2020) |
| "Pain is a common fear of those contemplating end of life, but severe pain is reported in less than 1 in 5 of our population in the last month of life." | ( Bush, SH; Hagarty, AM; Lapenskie, J; Talarico, R; Tanuseputro, P, 2020) |
| "Propofol injection pain is a very common problem during the induction of general anesthesia." | ( Ji, L; Lan, Y; Sun, W; Wu, Q; Xia, C; Xu, X; Yang, S; Yu, G, 2020) |
| "This definition of pain is cited in a lot of books." | ( Watanabe, K, 2020) |
| "Pain is a global health priority that is challenging to asses." | ( Ahmed, F; Cabot, PJ; Hall, WD; Mueller, JF; O'Brien, JW; Thomas, KV; Tscharke, B, 2020) |
| "Pain is evolutionarily hardwired to signal potential danger and threat." | ( Bingel, U; Elsenbruch, S; Forkmann, K; Schmidt, K, 2020) |
| "Pain is a common and disabling non-motor symptom (NMS) of Parkinson's disease (PD), which occurs through the course of the disease, often unrecognized and undertreated." | ( Bovi, T; Di Vico, IA; Geroin, C; Segatti, A; Squintani, G; Tinazzi, M, 2020) |
| "Pain is one of the main symptoms in 60 to 90 % of cancer patients." | ( Elsner, F; Hiddemann, S; Lampert, A; Neuner, I; Peuckmann-Post, V; Rolke, R; Stingl, J; Weber, S, 2020) |
| "Pain is a major concern associated with conventional photodynamic therapy (C-PDT)." | ( Cao, Y; Shi, L; Wang, P; Wang, X; Zhang, G; Zhang, H; Zhang, Y; Zhou, Z, 2020) |
| "Pain is a common symptom in pediatric patients with cancer, and most patients in palliative care will receive opioids." | ( Marks, A; Quirk, K; Smith, MA; Wright, J, 2020) |
| "Chronic pain is common in adult patients with CF and management presents a formidable challenge to providers." | ( Andrew T, B; Anita, L; Catherine, D; Trina, H; Yaoli, Y; Zubin, M, 2021) |
| "Pain is the most common symptom, and presentation of the disease may depend on which bones are affected, the extent of involvement, and the presence of complications." | ( des Bordes, JK; Rianon, NJ, 2020) |
| "Pathological pain is regulated by a balance between pro-algesic and analgesic mechanisms." | ( Celik, MÖ; Machelska, H, 2020) |
| "Pain is one of the most common and debilitating symptoms of hidradenitis suppurativa (HS)." | ( Borgstrom, M; Fernandez, JM; Hsiao, JL; Orenstein, LAV; Shi, VY; Thompson, AM, 2022) |
| "Pain is one of the most common medical challenges, reducing life quality." | ( Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H, 2020) |
| "Pain is poorly managed in patients with kidney disease." | ( Dember, LM; Jhamb, M; Liebschutz, J; Roy, PJ; Weltman, M, 2020) |
| "Pain is a hallmark of this condition and can be extremely difficult to control." | ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020) |
| "Drugs used to treat pain are associated with adverse effects, increasing the search for new drugs as an alternative treatment for pain." | ( Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH, 2020) |
| "Pain is an unpleasant sensation that has complex and varying causative etiology." | ( Afroz, M; Hasan, MF; Islam, MT; Mubarak, MS; Rouf, R; Sarker, DK; Shilpi, JA; Uddin, SJ, 2021) |
| "Pain is a common symptom among patients with kidney disease." | ( Balkrishnan, R; Han, Y; He, K; Hirth, RA; Hutton, DW; Saran, R; Steffick, DE, 2020) |
| "Pain is a frequent finding in surgical and trauma patients, and effective pain control remains a common challenge in the hospital setting." | ( George, S; Johns, M, 2020) |
| "Although severe pain is a major clinical manifestation of SCD, it remains unknown whether nociception plays a role in SCD pathogenesis." | ( Frenette, PS; Gulinello, M; Xu, C, 2021) |
| "Pain is a serious adverse event which frequently accompanies hematopoietic stem cell transplantation (HSCT)." | ( Gordon, L; Grosshans, N; Mehta, J; Rubin, H; Trifilio, S, 2021) |
| "Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage." | ( Pick, CG; Schreiber, S, 2021) |
| "Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of people on a daily basis." | ( Thyagarajan, B; Wang, M, 2022) |
| "Pain is an unpleasant sensory and emotional experience, often accompanied by the occurrence of a variety of diseases." | ( Li, W; Liao, X; Liu, Y; Su, Y; Wang, Q; Xu, Y; Yu, Y; Zhang, J; Zhang, S; Zhao, M, 2021) |
| "Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients." | ( Čeko, M; Kim, HJ; Kim, SG; Lee, JJ; Lee, SA; Park, BY; Park, H; Roy, M; Wager, TD; Woo, CW, 2021) |
| "Pain is a complex, unpleasant feeling and emotional experience associated with actual or potential tissue damage, and manifests itself in certain autonomous psychological and behavioral responses." | ( Lin, S; Tian, GH; Wang, LY; Wei, XH; Xia, GY; Xia, H, 2020) |
| "Although rectal pain is often not commonly associated with prolapse, it bothers many women and motivates older women to undergo evaluation." | ( Arnow, KD; Gurland, BH; Lee, A; Neshatian, L; Trickey, AW, 2021) |
| "Pain is an immunological response to an infection or inflammation and long-term use of pain management therapy includes the use of Nonsteroidal anti-inflammatory drugs, which is associated with the occurrence of toxicity as well as gastrointestinal bleeding." | ( Gaikwad, NJ; Gaikwad, SS; Patil, ML, 2021) |
| "Chronic pain is conceptualized as a persistent negative shock to lifetime utility that can be treated by pain relief medication." | ( Strulik, H, 2021) |
| "Although pain is a common symptom in the general population, impairments in glucose regulation alone does not seem to increase pain among older individuals." | ( Åström, MJ; Eriksson, JG; Haanpää, M; Kautiainen, H; Salonen, MK; von Bonsdorff, MB, 2021) |
| "Pain is a noxious stimulus caused due to tissue damage and varies from mild to severe." | ( Bhatnagar, A; Hasan, N; Jain, GK; Karwasra, R; Khan, N; Khanna, K; Khanna, S; Kumar, A; Nishad, DK; Popli, H; Rawat, S; Sharma, N, 2021) |
| "Chronic pain is a major global health issue that affects all populations regardless of sex, age, ethnicity/race, or country of origin, leading to persistent physical and emotional distress and to the loss of patients' autonomy and quality of life." | ( Côté, J; Marchand, S; Midavaine, É; Sarret, P, 2021) |
| "Chronic pain is highly comorbid with affective disorders, including major depressive disorder." | ( Donaldson, LF; Lumb, BM; Phelps, CE; Robinson, ES, 2021) |
| "Pain is one of the major symptoms complained about by patients in the prehospital setting, especially in the case of trauma." | ( Albrecht, R; Berger, Y; Grünenfelder, A; Meuli, L; Pietsch, U; Schurter, D; Theiler, L; Wenzel, V, 2021) |
| "Pain is a major comorbidity of sickle cell disease (SCD)." | ( Gupta, K; Mittal, A; Sagi, V; Tran, H, 2021) |
| "Pain is a phenomenon present in the majority of the population, affecting, among others, the elderly, overweight people, and especially recently operated patients, analgesia being necessary." | ( de Andrade, ARB; de Britto Lira Nogueira, MC; de Santana, DP; de Siqueira Ferraz-Carvalho, R; Gibson, VP; Kishishita, J; Leal, LB; Santos-Magalhães, NS, 2021) |
| "Burn pain is known to be excruciating, and while burn care has greatly advanced, treatment for burn-related pain is lacking." | ( Furer, A; Giladi, S; Goder, D; Zilberman, M, 2021) |
| "Pain is one of the cardinal signs accompanying inflammation." | ( Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A, 2021) |
| "Pain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions." | ( Beaudet, N; Bégin-Lavallée, V; Belkouch, M; Dansereau, MA; Longpré, JM; Mélik-Parsadaniantz, S; Midavaine, É; Sarret, P, 2021) |
| "Bumetanide-induced pain is more common than previously described." | ( Brighton, DD; Herges, JR; Herges, LB; Jentzer, JC; Ou, NN, 2021) |
| "Pain is a common side effect of intravenous injection of propofol." | ( Choice, C; Greige, N; Hwang, LK; Larios-Valencia, J; Nash, DW; Pothula, A; Yedlin, A, 2021) |
| "Persistent pain is a prevalent symptom of Parkinson's disease (PD), which is related to the loss of monoamines and neuroinflammation." | ( Assis, DV; Barbosa, GR; Berzuíno, MB; Campos, ACP; Fonoff, ET; Freire, HMRC; Lopes, PS; Pagano, RL, 2021) |
| "Pain is a symptom of ninety percent of human diseases, and pain management is a very important medicinal problem." | ( Laev, SS; Salakhutdinov, NF, 2021) |
| "Pain is a known complication in persons with hemophilia (PWH) as a result of muscle and joint bleeding." | ( Baumann, K; Buckner, T; Curtis, RG; Durben, N; Fritz, R; Humphrey, C; Humphries, TJ; Lambing, AY; Mauer, K; Newman, J; Nichols, CD; Santaella, M; Thibodeaux, CB; Wheat, E; Witkop, M, 2022) |
| "Pain is a core domain of psoriatic arthritis (PsA)." | ( Azevedo, V; Bushmakin, AG; Cappelleri, JC; de Vlam, K; Fallon, L; Fleischmann, R; Mease, PJ; Ogdie, A; Taylor, PC; Woolcott, J, 2021) |
| "Although persistent pain is estimated to affect about 20% of the adult population, current treatments have poor results." | ( Georgoussi, Z; Parenti, C; Pasquinucci, L; Reina, L; Tomarchio, E; Turnaturi, R, 2021) |
| "Pain is a common but often ignored symptom in COVID-19 patients." | ( Sir, E, 2021) |
| "Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptor subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial." | ( Al-Madol, M; Khalefa, BI; Li, L; Mousa, SA; Schäfer, M; Shaqura, M; Treskatsch, S, 2021) |
| "Residual limb pain is common after amputation." | ( Lui, G; Sussman, WI, 2021) |
| "Pain is a complex problem, particularly in underserved populations." | ( Ahmed, E; Chen, J; Dhingra, L; Dieckmann, NF; DiFiglia, S; Ginzburg, R; Nosal, S; Portenoy, R; Rodriguez, S; Schiller, R; Schroff, N; Shuman, S; Teets, R, 2021) |
| "Chronic pain is induced and supported by proinflammatory cytokines, free radicals, and reactive oxygen species creating a self- sustaining vicious circle." | ( Cannavò, L; Di Rosa, G; Gitto, E; Marseglia, L; Perrone, S; Viola, V, 2022) |
| "Pain is currently understood to be an important phenotype that those two neurohormones strongly downregulate." | ( Hwang, SW; Jung, ST; Kim, Y; Lim, JY; Zheng, H, 2021) |
| "Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom." | ( Elisei, L; Galdino, G; Malta, I; Moraes, T; Novaes, R, 2022) |
| "Pain is associated with increased risk for harmful substance use." | ( Burke, C; McKee, SA; Moore, KE; Peltier, MR; Roberts, W; Verplaetse, TL; Zakiniaeiz, Y, 2021) |
| "Bone pain is the primary problem for patients with osteoporosis." | ( Ge, Y; Li, H; Lin, Y; Lin, Z; Tang, B; Tian, Y; Wang, K; Wang, Y; Wu, Y; Zhang, J, 2021) |
| "Pain is common among cirrhosis patients, particularly those hospitalized with acute illness." | ( Auerbach, A; Hohmann, SF; Lai, JC; Rubin, JB; Shui, AM, 2023) |
| "Pain is highly prevalent among older people, and treatment is complicated because of comorbidities and polypharmacy." | ( Gustafsson, M; Lövheim, H; Sjölander, M, 2021) |
| "Pain is a common and debilitating symptom of inflammatory bowel disease (IBD)." | ( Gold, MS; Loeza-Alcocer, E, 2022) |
| "Pain is still an underestimated symptom in CF patients." | ( Brinkmann, F; Dillenhöfer, S; Hoffmann, AT; Lücke, T; Maier, C, 2022) |
| "Pain is one of the most severe concerns in tongue cancer patients." | ( Asano, S; Furukawa, A; Hayashi, Y; Hitomi, S; Iwata, K; Kaneko, T; Koyama, R; Shibuta, I; Shinoda, M; Yonehara, Y, 2021) |
| "Pain is a frequent adverse event during photodynamic therapy, which can limit treatment acceptance." | ( Ag, S; Er, O; Ha, M; Lpf, A; Mb, R; Mmc, M; Mr, G, 2022) |
| "Pain is a physiological response to bodily damage and serves as a warning of potential threat." | ( Contreras, JE; Griffith, TN; Muñoz, MF, 2021) |
| "Pain is one of the most distressing symptoms for patients with advanced cancer." | ( Jarlbæk, L; Rasmussen, SS, 2021) |
| "Periodontal pain is a public health problem derived from different conditions, including periodontal diseases, prosthetic complications, and even extractions performed by dentist." | ( Caballero-Florán, IH; Cortés, H; Del Prado-Audelo, MAL; Figueroa-González, G; Giraldo-Gomez, DM; González-Del Carmen, M; González-Torres, M; Leyva-Gómez, G; Reyes-Hernández, OD; Robles-Kanafany, CM; Sharifi-Rad, J, 2021) |
| "Pain is a common symptom accompanying several clinical conditions and causes serious distress to patients." | ( Cannella, N; Ciccocioppo, R; Guo, Z; Li, H; Qin, D; Shi, F; Wang, Y, 2022) |
| "Pain is similarly reduced for periocular botulinum toxin injections reconstituted with preserved saline compared with unpreserved saline." | ( Hunt, SV; Malhotra, R, 2022) |
| "The pain is associated with ipsilateral autonomic symptoms (most commonly lacrimation, conjunctival injection, nasal congestion or rhinorrhea, ptosis, edema of the eyelid, sweating of the forehead or face, and miosis) and a sense of agitation or restlessness." | ( Bailey, J; Hawks, MK; Malu, OO, 2022) |
| "Pain is a significant concern among older adults with Alzheimer's disease and related dementias (ADRD)." | ( Cheng, Z; Heffner, KL; Kim, Y; Li, Y; Quiñones-Cordero, MM; Wang, J; Yu, F, 2022) |
| "Pain is an integrative phenomenon coupled with dynamic interactions between sensory and contextual processes in the brain, often associated with detectable neurophysiological changes." | ( Chen, D; Guan, C; Kavitha, PT; Loy, FL; Ng, SH; Phua, KS; Tjan, SY; Wang, C; Yang, SY; Zhang, H, 2022) |
| "Pain is a common symptom in patients undergoing cancer treatment." | ( Levoy, K; Meghani, SH; Walker, SL, 2022) |
| "The pain is in part due to irritation of vascular endothelial cells." | ( Chan, P; Chen, CY; Chuang, CM; Leung, YM; Shiao, LR; Wong, KL; Wu, CH; Yen, PS, 2022) |
| "Pain is growing to be a massive health issue across the globe." | ( Lei, F; Yan, Z, 2022) |
| "Pain is also influenced by mesocorticolimbic DA function, but it is not known whether pain or cannabinoid analgesia in adults is altered by early exposure to cannabinoids." | ( Craft, RM; Gogulski, HY, 2022) |
| "Esophageal pain is mediated by sensory nerves, most importantly by the activation of the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor." | ( Alleleyn, AME; Conchillo, JM; Csekő, K; Helyes, Z; Kajtár, B; Keszthelyi, D; Masclee, AAM; Rinsma, NF; Winkens, B, 2022) |
| "In dentistry, pain is a rather inevitable perception that often plagues both the care provider and receiver." | ( Kaarthikeyan, G; Murthykumar, K; Rajasekar, A, 2022) |
| "Dental pain is a common complaint in patients undergoing endodontic treatment." | ( Ramli, R; Sivakumar, D, 2022) |
| "Pain is a significant symptom associated with many musculoskeletal conditions leading to functional impairment and poor quality of life." | ( Hamilton, JA; Lee, KM; Sherlock, JP, 2022) |
| "Pain is the first symptom of acute and chronic inflammation." | ( Almeida, LD; Badenoch, B; Beatriz, A; Cristina Toffoli-Kadri, M; da Silva Gomes, R; da Silva Júnior, EN; da Silveira, IOMF; Fernandes, J; Hortelan, CRW; Janaína de Campos, L; Juliano Oliveira, R; Martins, ACF; Mohammad, J; Moslaves, ISB; Muller, JAI; Okuyama, TT, 2022) |
| "Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual." | ( Abdalla, HB; Basting, RT; Clemente-Napimoga, JT; Napimoga, MH; Trindade da Silva, CA, 2022) |
| "Pain is a global, complex health problem that includes physical, emotional, and social components." | ( Abdel-Fattah, A; Abdel-Monem, AH; Abdelazim, AH; Almrasy, AA; Ramzy, S; Shahin, M, 2022) |
| "Chronic pain is common in older people." | ( Bloomfield, K; Boyd, M; Broad, JB; Calvert, C; Connolly, MJ; Higgins, AM; Hikaka, J; Peri, K; Tatton, A; Wu, Z, 2022) |
| "Pain is commonly reported in people living with myositis." | ( Bhai, S; Bhashyam, A; Filmore, E; Gonzalez Ramos, O; Lubinus, M; Williams, J; Wilson, L, 2022) |
| "Pain is a commonly reported symptom in myositis with variable treatment strategies, including opioid medications." | ( Bhai, S; Bhashyam, A; Filmore, E; Gonzalez Ramos, O; Lubinus, M; Williams, J; Wilson, L, 2022) |
| "Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches." | ( Gable, J; Golovko, MY; Golovko, SA; Gupta, K; Johns, M; Kalyuzhny, AE; Khasabov, SG; Khasabova, IA; Kiven, S; Seybold, VS; Simone, DA, 2023) |
| "Pain is a common symptom that impairs the quality of life for people around the world." | ( Diachkova, E; Grin, M; Korenev, G; Kuznetsov, N; Morozova, N; Noev, A; Pankratov, A; Suvorov, N; Usachev, M; Vasil'ev, Y, 2022) |
| "Pain is a primary driver of action." | ( Coll, MP; Rainville, P; Roy, M; Slimani, H; Vachon-Presseau, É; Wager, TD; Woo, CW, 2022) |
| "Pain is common in hand osteoarthritis (OA) and multiple types may occur." | ( Allaart, CF; Böhringer, S; Boonen, AERCH; Kloppenburg, M; Kortekaas, MC; Kroon, FPB; Niesters, M; Reijnierse, M; Riyazi, N; Rosendaal, FR; Starmans-Kool, M; Turkstra, F; van de Stadt, LA; van der Meulen, C; van Zeben, J, 2022) |
| "Pain is the dominant symptom in hand OA, with an unclear aetiology." | ( Allaart, CF; Böhringer, S; Boonen, AERCH; Kloppenburg, M; Kortekaas, MC; Kroon, FPB; Niesters, M; Reijnierse, M; Riyazi, N; Rosendaal, FR; Starmans-Kool, M; Turkstra, F; van de Stadt, LA; van der Meulen, C; van Zeben, J, 2022) |
| "Itch and pain are both unpleasant, but they are discrete sensations." | ( Kobayashi, K; Noguchi, K; Okubo, M; Saeki, A; Yamanaka, H, 2022) |
| "Pain is the most important symptom in OA, driving medical care, disability, reduced functionality, and decreased quality of life." | ( Arendt Nielsen, L; Beck, C; Hygge Blakeman, K; Liseth Hansen, J; Robinson, R; Rolfson, O; Schepman, P; Wilhelm, S, 2023) |
| "Pain is influenced by various factors, such as fear, anxiety, and memory." | ( Kondo, M; Koyama, Y; Kubo, E; Masui, K; Mitani, O; Nakamura, Y; Okamoto, T; Shimada, S; Sumi, T; Usui, N, 2022) |
| "Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment." | ( Akashi, M; Amano, R; Arimoto, S; Hasegawa, T; Kakei, Y; Kyotani, K; Noda, T; Saito, I; Takeda, D; Yatagai, N, 2022) |
| "Pain is an alarm mechanism to prevent body damage in response to noxious stimuli." | ( Arévalo, JC; Cañada-García, D; Martín-Zanca, D; Sánchez-Sánchez, J; Vicente-García, C, 2023) |
| "Pain is a sensation a humans sense as a protective mechanism against physical injury." | ( Afzal, M; Asaruddin, MR; Khan, MSA; Mahmood, MH; Rahman, HU; Sama, NU, 2022) |
| "Pain is one of the most common concomitant symptoms among cancer patients." | ( Chen, P; Fu, Y; Jia, Y; Li, J; Liu, D; Shou, F; Sun, Y; Wang, Y; Wei, H; Yao, W; Yu, M; Zhang, X; Zheng, R; Zheng, Y; Zhou, J; Zhu, J, 2022) |
| "Procedural pain is a common burden in critical care treatment and the prediction of nociceptive reactions remains challenging." | ( Bublitz, VK; Jurth, C; Lezius, F; Lichtner, G; Schaaf, L; von Dincklage, F; Zimmermann, V, 2022) |
| "This pain is not only distressing to the patient and his or her parents, but often reflects poorly on an otherwise well performed procedure." | ( Opperman, JB; Tshifularo, MI, 2022) |
| "This pain is usually treated with opioids, and most commonly with morphine." | ( Araguz, K; Cunningham, R; Hemphill, A; Hook, MA; Rau, J; Stefanov, A; Weise, L, 2022) |
| "Chronic joint pain is common in patients with osteoarthritis (OA)." | ( Chao, D; Hogan, QH; Pan, B; Tran, H, 2022) |
| "Pain is a major problem in 90% of patients with chronic pancreatitis (CP)." | ( Gopan, A; Jain, SK; Mathias, A; Mishra, P; Poddar, U; Sarma, MS; Srivastava, A; Yachha, SK, 2023) |
| "Pain is one of the most frequent symptoms in cancer patients and has a negative impact on their physical, emotional and functional status, as well as their quality of life (QOL)." | ( Arundorn, T; Dechaphunkul, A; Prisutkul, A; Ruangdam, A; Sathitruangsak, C; Songserm, M, 2022) |
| "Pain is constructed through complex interactions among multiple brain systems, but it remains unclear how functional brain networks are reconfigured over time while experiencing pain." | ( Lee, DH; Lee, JJ; Lee, S; Woo, CW, 2022) |
| "Pain is measured by facial grooming behavior stimulated by capsaicin, the alternation of body weight and food intake was also recorded to reflect the OM pain." | ( Ma, H; Mao, R; Tang, Y; Yan, H; Zhang, Y; Zhao, Y, 2023) |
| "Pain is a major problem that burdens the health and economy of societies worldwide." | ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022) |
| "Although pain is common in osteoarthritis, most people fail to achieve adequate analgesia." | ( Chou, L; Cicuttini, FM; Leaney, AA; Lyttle, JR; Segan, J; Urquhart, DM; Wluka, AE, 2022) |
| "Inflammatory pain is the most important clinical symptom of inflammatory diseases." | ( Chenxi, Z; Hao, Y; Jie, K; Mingpeng, Y; Shiyu, D; Sihan, C; Xiao, T; Xinqiang, Y; Yanlin, Z; Yuanyuan, J; Yumeng, H; Zhipeng, Y, 2022) |
| "Pain is therefore a critical aspect of hemophilia." | ( Buget, MI; Canbolat, N; Dinç, T; Kılıçoğlu, Öİ; Koç, B; Koltka, K; Zulfikar, B, 2022) |
| "Pain is a major non-motor symptom that contributes to impaired quality of life in Parkinson's disease (PD)." | ( Chen, Y; Cheng, O; Cui, J; Li, C; Li, Y; Zhu, D, 2022) |
| "Pain is a private experience, whose assessment relies on subjective self-reporting." | ( Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C, 2022) |
| "Since pain is associated with autonomic arousal, here we used readouts of autonomic activity to assess objectively the arousing effect of somatic stimuli in a human model of hyperalgesia." | ( Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C, 2022) |
| "Acute burn pain is difficult to manage, and poorly managed pain can lead to deleterious consequences such as post-traumatic stress disorder, prolonged recovery, chronic pain and long-term dependence on opioids." | ( Bishop, P; Dedeo, M; Eshraghi, N; Liechty, KL; Ogden, E; Shields, K, 2023) |
| "Pain is a multidimensional construct." | ( Caritis, S; Krans, E; LaSorda, KR; Lim, G; Rosario, BL; Wong, CA, 2023) |
| "Persistent pain is a common and disabling health problem that is often difficult to treat." | ( Blomé, S; Fust, J; Gedin, F; Jensen, K; Lalouni, M; Pontén, M; Raquette, A; Thompson, WH; Vadenmark Lundquist, V, 2022) |
| "Persistent pain is a common and disabling health problem that is often difficult to treat." | ( Blomé, S; Fust, J; Gedin, F; Jensen, K; Lalouni, M; Pontén, M; Raquette, A; Thompson, WH; Vadenmark Lundquist, V, 2022) |
| "BACKGROUNDChronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients." | ( Berger, E; Binshtok, AM; Davidson, E; Edvardson, S; Elpeleg, O; Ghazalin, S; Katz, B; Kfir-Erenfeld, S; Lev, S; Maayan, C; Minke, B; Peters, M; Zaguri, R, 2023) |
| "BACKGROUNDChronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients." | ( Berger, E; Binshtok, AM; Davidson, E; Edvardson, S; Elpeleg, O; Ghazalin, S; Katz, B; Kfir-Erenfeld, S; Lev, S; Maayan, C; Minke, B; Peters, M; Zaguri, R, 2023) |
| "Pain is measured before, during, and after treatment with a visual analog scale (1-10)." | ( Alfaro, K; Alonzo, TA; Bonilla, J; Castle, P; Conzuelo Rodriguez, G; Cremer, M; Felix, JC; Hernández Jovel, DM; Masch, RJ; Murillo, R; Puentes, LO; Qu, X; Soler, M; Sun, J; Wu, S, 2022) |
| "Pain is measured before, during, and after treatment with a visual analog scale (1-10)." | ( Alfaro, K; Alonzo, TA; Bonilla, J; Castle, P; Conzuelo Rodriguez, G; Cremer, M; Felix, JC; Hernández Jovel, DM; Masch, RJ; Murillo, R; Puentes, LO; Qu, X; Soler, M; Sun, J; Wu, S, 2022) |
| "Chronic pain is one of the most critical health issues worldwide." | ( Ballet, S; Cavelier, F; Desgagné, M; Previti, S; Sarret, P; Tourwé, D, 2023) |
| "Pain is the most common presenting symptom in SCD patients with COVID-19." | ( Clarke, K; El Rassi, F; Hall, MAK; McLemore, M; Moussa, M; Shin, YM, 2023) |
| "Pain is one of the major prehospital symptoms in trauma patients and requires prompt management." | ( Albrecht, R; Fischer, H; Grünenfelder, A; Hossfeld, B; Pietsch, U; Rüst, CA; Wenzel, V, 2023) |
| "Inflammatory pain is part of the body's defense mechanism and plays an important role in the healing process." | ( Ben Akacha, A; Ben Ali, R; Ben Othman, A; El May, MV, 2023) |
| "Pain is one of the most frequent causes for patients to seek medical care." | ( Godínez-Chaparro, B; Mendoza-Pérez, F; Pérez-Ramos, J; Santamaria-Anzures, J, 2023) |
| "As pain is an important factor in EM, optimal analgesia should be sought, which to date has been treated primarily with non-steroidal anti-inflammatory drugs (NSAIDs), metamizole or, in extreme cases, opioids." | ( Guan, Q; Mechsner, S; Sehouli, J; Velho, RV, 2023) |
| "Pain is immediate and severe and there are no clear first aid or definitive treatment recommendations." | ( Jackson, A; Little, M; Ryan, F; Young, R, 2023) |
| "Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular." | ( Sun, CK; Tsai, TH, 2023) |
| "Although treating pain is associated with improved quality of life, most respondents did not support TA use in the ED." | ( Anderson-Quiñones, C; Asbell, P; Tolley, EA; Vestal, R; Zhu, R, 2023) |
| "Relief of ongoing pain is a potent motivator of behavior, directing actions to escape from or reduce potentially harmful stimuli." | ( Becker, S; Desch, S; Flor, H; Schweinhardt, P; Seymour, B, 2023) |
| "Cancerrelated pain is often caused by the tumor itself, especially when the tumor is pressing on nerves." | ( Dash, SR; Kundu, CN, 2023) |
| "Nociplastic pain is a severe health problem, while its mechanisms are still unclear." | ( Chen, L; Feng, Z; Li, X; Mei, X; Pan, Y; Wu, C; Yin, C, 2023) |
| "In mammals, pain is regulated by the combination of an ascending stimulating and descending inhibitory pain pathway." | ( Baek, M; Cho, EH; Jang, W; Kim, C; Oh, M, 2023) |
| "Pain is a significant symptom experienced frequently by individuals with sickle cell disease (SCD)." | ( D'Alton, S; Johnson, M; Kanter, J; Phillips, S; Schlenz, AM, 2023) |
| "Although pain is common, significant local tissue injury does not occur." | ( Cue, K; Gilbert, MB; Greene, SC; Khan, R; Rahimi, J, 2023) |
| "Pain is a common manifestation of several benign and malignant conditions." | ( Bauones, S; Cazzato, RL; Dalili, D; Gangi, A; Gantzer, J; Garnon, J; Koch, G; Kurtz, JE, 2023) |
| "Inflammatory pain is induced by trauma, infection, chemical stimulation, etc." | ( Cao, J; Lu, Y; Qin, Z; Tao, T; Wang, H; Zeng, F; Zhao, C; Zheng, H, 2023) |
| "We argue that pain is not needed to protect the body from damage unless the organism is able to make free choices in action selection." | ( Elwood, RW; Farnsworth, KD, 2023) |
| "Pain is the main symptom of osteoarthritis, which severely reduces the patients' quality of life." | ( Ding, JQ; Liu, L; Sun, X; Xie, M; Yang, HY; Yu, LZ; Zhen, SQ; Zhu, HL, 2023) |
| "Management of pain is a component of 80% of all emergency department (ED) visits, and intravenous (IV) opioids are most commonly used to treat moderate to severe pain." | ( Coleska, A; Dinh, D; Oh, A; Parwani, V; Rothenberg, C; Venkatesh, AK, 2023) |
| "Acute corneal pain is a common complaint that causes significant distress to patients and continues to challenge therapeutic avenues for pain management." | ( Courtney, E; Faktorovich, EG; Kelly, MEM; Lafreniere, JD; Szczesniak, AM, 2023) |
| "Pain is a self-reported, dichotomous measure where participants responded to whether they were often troubled with pain and whether this experience interfered with their ability to carry out daily household chores." | ( Ahmed, W; Javed, NB; Maurya, C; Mohanty, P; Muhammad, T; Pai, M, 2023) |
| "Pain is associated with many circumstances, including inflammatory reactions, which arise from modification of the features of signaling pathways." | ( Ling, X; Wang, W, 2023) |
| "Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions." | ( Almeida, JRGS; Baj, T; Batista, MVA; Coutinho, HDM; de Oliveira, MA; Duarte, MC; Guimarães, AG; Kowalska, G; Kowalski, R; Pina, LTS; Quintans, JSS; Quintans-Júnior, LJ; Santos, LABO; Santos, WBR; Serafini, MR; Trindade, GGG, 2023) |
| "Pain is one of the most frequently reported experiences amongst children with Juvenile Idiopathic Arthritis (JIA); however, the management of JIA pain remains challenging." | ( Brandelli, YN; Chambers, CT; Huber, AM; Mackinnon, SP; Parker, JA; Piccolo, O; Stinson, JN; Wildeboer, EM; Wilson, JP, 2023) |
| "Dental pain is a main clinical problem in the elderly population and its assessment and treatment make special challenges for health care services." | ( Aarab, G; Abbasnejad, M; Esmaeili-Mahani, S; Lobbezoo, F; Raoof, M; Torkzadeh-Mahani, S, 2023) |
| "Pain is the main symptom of osteoarthritis (OA) with approximately 50% of patients reporting moderate-to-severe pain." | ( Auer, DP; Cooper, D; Knaggs, R; Kurien, T; Scammell, BE; Walsh, DA; Zedan, Y, 2023) |
| "Joint pain is one of the most debilitating symptoms of rheumatoid arthritis (RA) and patients frequently rate improvements in pain management as their priority." | ( Agalave, NM; Barbier, J; Bersellini Farinotti, A; Eijkelkamp, N; Grönwall, C; Hunt, MA; Jimenéz-Andrade, JM; Jurczak, A; Klareskog, L; Krock, E; Marchand, F; Martinez-Martinez, A; Raoof, R; Rudjito, R; Sandor, K; Simon, N; Svensson, CI; Vazquez-Mora, JA; Wang, Z, 2023) |
| "Pain is the most common cause of office hysteroscopy (OH) failure." | ( Babczyk, D; Baran, R; Gawron, I; Jach, R; Pietrus, M; Zmaczynski, A, 2023) |
| "Pain is a common experience that can range from mild annoyance to debilitating agony." | ( Al-Alsadoon, L; Al-Saffar, M; Taqa, G, 2023) |
| "Upper lateral hip pain is a common complaint in adults and is referred to as greater trochanteric pain syndrome (GTPS) and is more prevalent among older women." | ( Baker, C; Chan, F; Gonzalez, D; Kohan, L; Naeimi, T; Oakes, D; Ortiz, N; Patel, A; Rosenburg, J; Sayed, D; Schulz, J; Schwechter, E; Sitapara, K; Wahezi, SE; Yee, M; Yerra, S; Yih, C, 2023) |
| "Pain is the key symptom of AOM and central to children's and parents' experience of the illness." | ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023) |
| "Cumulative pain is associated with morbidities, including adverse neurodevelopmental outcomes." | ( Shah, PS; Shah, VS; Torgalkar, R, 2023) |
| "The origin of pain is likely neuropathic." | ( Bugayong, ML; DeVita, MA; Shabbir, M, 2023) |
| "Chronic pain is a worldwide refractory health disease that causes major financial and emotional burdens and that is devastating for individuals and society." | ( Acramel, A; Daulhac, L; Jacquot, Y; Jouffre, B; Mallet, C, 2023) |
| "Musculoskeletal pain is a widely experienced public healthcare issue, especially after traumatic muscle injury." | ( Camponogara, C; da Silva, AM; Dalenogare, DP; de Amorim Ferreira, M; de David Antoniazzi, CT; Dos Santos Stein, C; Ferreira, J; Kudsi, SQ; Meira, GM; Moresco, RN; Oliveira, SM; Silveira, PCL; Trevisan, G; Zaccaron, R, 2023) |
| "Pain is one of common symptoms of PD." | ( Ce, Z; Jiren, Z; Pinyuan, Z; Tian, W; Ting, L; Wenbo, Z; Zhigang, M, 2023) |
| "Pain is subjective, so patient-reported experience with pain and analgesia is essential for healthcare professionals." | ( Eppler, F; Häske, D; Heinemann, N; Schempf, B, 2023) |
| Excerpt | Reference |
|---|
| "For the treatment of mild pain salicylic acid is still unsurpassed." | ( Adler, R, 1975) |
| "1 The treatment of pain of cardiac origin requires a knowledge of the haemodynamic action of the analgesic agents used." | ( Coltart, DJ; Malcolm, AD, 1979) |
| "3 The best choices for treatment of pain are the most potent and long-acting drugs of this group with a wide safety margin." | ( De Castro, J, 1979) |
| "A new treatment for painful neuromas in the hand was used on thirtty-three patients." | ( Eaton, RG; Herndon, JH; Littler, JW, 1976) |
| "A questionnaire concerning the treatment of cancer pain was sent to 10% and 5% random samples of Finnish physicians in 1985 and in 1990, respectively." | ( Vainio, A, 1992) |
| "After 2-weeks' treatment, pain on passive movement of the hip joint was statistically significantly less severe on CR dihydrocodeine than on dextropropoxyphene/paracetamol (p = 0." | ( Costello, F; Eves, MJ; James, IG; Lloyd, RS; Miller, AJ, 1992) |
| "Efficacy has been demonstrated for the treatment of pain in 84% of 322 breast cancer patients and 77% of 444 prostate cancer patients found in a review of the literature." | ( Elgazzar, AH; Kapilivsky, A; Silberstein, EB, 1992) |
| "Strontium-89 has been used for the treatment of painful bony metastases in patients suffering from disseminated adenocarcinoma of the prostate, with a variable proportion of patients obtaining clinically significant reductions in analgesic requirements." | ( Mertens, WC; Porter, AT; Powe, JE; Reid, RH, 1992) |
| "There have been analyzed the results of treatment of the pain syndrome after the traumata of the lower limbs by the IRT method (106 patients), compared the terms and the results of the treatment by the above mentioned methods as well as by the separate acupuncture analgesia and electro-analgesia methods." | ( Bachurin, EP; Medvedev, IP; Tkachuk, VN, 1991) |
| "Naproxen is also effective in treating the pain and associated symptoms of primary or secondary dysmenorrhoea, and decreases excessive blood loss in patients with menorrhagia." | ( Clissold, SP; Todd, PA, 1990) |
| "Although CMZ was useful in treatment of pain, caution should be employed in this disease." | ( Barton, NW; Filling-Katz, MR; Fink, JK; Merrick, HF; Miles, RB; Sokol, J, 1989) |
| "Inadequate treatment of cancer pain with narcotics may stem, in part, from these events." | ( Hill, CS, 1989) |
| "Patients expect treatment for a painful stiff shoulder." | ( Beeney, N; Dacre, JE; Scott, DL, 1989) |
| "Although ASA is important in the treatment of pain in rheumatic diseases, it may contribute to abnormal sleep patterns." | ( Helms, C; Landis, CA; Levine, JD; Robinson, CR, 1989) |
| "They have been of value in treating pain of cancer and spasticity through spinal subarachnoid catheters." | ( Penn, RD, 1985) |
| "The satisfactory treatment of cancer pain requires a variety of practical management strategies." | ( Barnett, JB; Brigden, ML, 1987) |
| "It may be used in the treatment of cancer pain, or in patients with chronic arthritides or other forms of chronic non-cancer pain who require a potent conventional analgesic, as an alternative to the weak opioids or to morphine in low doses." | ( Hanks, GW, 1987) |
| "Successful treatment of pain syndromes is one of the most common and most difficult problems facing family physicians." | ( Stauffer, JD, 1987) |
| "Effect of this treatment on the pain could be evaluated in 16 patients." | ( Chuang, VP; Claghorn, L; Mavligit, G; Patt, YZ; Peters, RE; Wallace, S, 1985) |
| "In patients treated with chymopapain, unrelieved sciatica was the most common cause of clinical treatment failure." | ( Alexander, AH; Burkus, JK; Mitchell, JB, 1988) |
| "If emergency physicians would treat the pain of their patients as they would want it to be treated in themselves or their families, then we will have made great strides as a specialty in mastering the art and science of analgesia." | ( Paris, PM, 1987) |
| "We have utilized 89Sr as palliative treatment for bone pain secondary to metastatic cancer in the skeleton of over 200 patients." | ( Martin, NL; Preston, DF; Robinson, RG; Spicer, JA; Wegst, AV, 1987) |
| "These findings suggest that treatment of pain may reduce morbidity, and thereby may have significant benefits beyond that provided by slowing of the disease process." | ( Basbaum, AI; Dardick, SJ; Levine, JD, 1986) |
| "The average treated pain rating, mean patient satisfaction rating, and mean number of days withdrawn from each drug all showed significant differences between prednisone, aspirin, and placebo." | ( Anderson, J; Buchanan, WW; Lee, P; Webb, J, 1973) |
| "Drug treatment of pain is largely based on clinical experience." | ( Adriaensen, H; van de Walle, J; Vanmeenen, H, 1981) |
| "The results showed that both treatments reduced pain severity significantly for all the parameters measured; however, most patients needed additional pain relief." | ( Orö, L, 1984) |
| "The effect of treatment of pain was assessed daily using a visual analogue scale." | ( Høivik, HO; Moe, N, 1983) |
| "Most of the patients treated had pain due to malignant disease." | ( Erskine, WA; Melvill, RL, 1981) |
| "Failure of epidural 2 mg in the treatment of severe pain other than labour." | ( Davenport, HT; Husemeyer, RP; O'Connor, MC, 1980) |
| "During the last three days of each dose treatment, the pain score was determined by the patients and the plasma concentrations of carbamazepine and its epoxide metabolite were measured." | ( Bertilsson, L; Ekbom, K; Rane, A; Tomson, T; Tybring, G, 1980) |
| "The optimal treatment of pain requires an understanding of the mechanisms involved." | ( Woolf, CJ, 1994) |
| "Standard dosing of opioids adequately treats most cancer pain in children; however, a significant group requires more extensive management." | ( Berde, CB; Collins, JJ; Grier, HE; Kinney, HC, 1995) |
| "Complementary drugs to treat pain were used in 13." | ( Calles Gato, MD; Hernández Moreno, J; López de Castro, F; Muñoz González, F; Sánchez del Viso, Y; Sánchez Muñoz, C, 1995) |
| "The pretreatment pain questionnaire was completed by 86 of these patients." | ( Genzen, JR; Skobieranda, FG; Solomon, GD, 1995) |
| "Lidocaine should not be used to treat painful mouth lesions in children until further safety data are available." | ( Druckenbrod, RW; Gonzalez del Rey, J; Wason, S, 1994) |
| "Furthermore, early treatment of painful crisis with this technique may improve oxygenation, a critical factor in the evolution of further sickling." | ( Billett, C; Casella, JF; Dover, G; Tobin, JR; Yaster, M, 1994) |
| "We found that alfentanil pretreatment reduced pain on injection of propofol (P = 0." | ( Bowen, DJ; Fletcher, JE; Seavell, CR, 1994) |
| "The use of morphine in the treatment of cancer pain is widely accepted among people taking care of cancer patients and concerned with pain relief." | ( Lossignol, DA, 1993) |
| "The mean pretreatment pain score, on a scale of 0 to 10 (0 = no pain) was 9." | ( Campbell, JN; Pappagallo, M, 1994) |
| "Newer systemic modalities to treat skeletal pain such as the bisphosphonates or radionuclides may in the future change some of our current approaches." | ( Herrmann, R; Lohri, A, 1996) |
| "It was also effective for the treatment of pain from myocardial ischaemia, ureteric colic and acute trauma." | ( Grond, S; Lehmann, KA; Radbruch, L, 1996) |
| "One patient received only one treatment since her pain symptoms resolved after the first treatment." | ( al Balawi, S; Feinmann, C; Tariq, M, 1996) |
| "Effective treatment of acute pain secondary to surgery and trauma is often a complex and perplexing task." | ( Hellyer, PW, 1997) |
| "Adequate treatment of pain in ICU patients should be an integral part of ICU management, as inadequately treated pain leads to a series of complications that may counteract the success of ICU treatment." | ( Kröll, W; List, WF, 1997) |
| "Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities." | ( Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M, 1998) |
| "Options for treating chronic pain of non-malignant origin are more controversial." | ( Angel, IF; Carey, ME; Gould, HJ, 1998) |
| "After the treatment the mean pain score became 3." | ( Correa, CF; Goes, FC; Marcon, RM; Müller, FS; Pimenta, CA; Teixeira, MJ, 1998) |
| "Adequate treatment of pain in children with cancer is a critical issue, and is of equal importance as discussions concerning chemotherapy, surgery and radiotherapy." | ( Bernard, JL; Buttin, C; Camboulives, J; Coze, C; Fallouh, K; Gentet, JC; Marty, JY; Portas, M, 1998) |
| "A variety of treatments for the pain were ineffective." | ( McGraw, T; Stacey, BR, 1998) |
| "The goal of therapy is to treat chronic pain while minimizing side effects and optimizing the patient's functional status." | ( Leland, JY, 1999) |
| "Successful pharmacologic treatment of cancer pain is founded upon careful assessment and measurement of pain before and during therapy." | ( Jage, J; Weber, M, 1999) |
| "It is indicated in the symptomatic treatment of pain and inflammatory or degenerative arthropathies: osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, abarticular inflammations, posttrauma or postoperative inflammations." | ( Scheen, AJ, 1999) |
| "The most frequent side effect of G-CSF treatment is bone pain, which occurs in over 80 percent of healthy progenitor cell donors." | ( Brown, DM; Froberg, MK; Garg, UC; Geis, M; McCullough, J; Stroncek, DF, 1999) |
| "The choice of analgesic for treating pain due to excessive nociception was greatly facilitated by the introduction of the WHO three-step approach." | ( Bauwens, MC; Giroud, JP; Rouveix, B, 1999) |
| "The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost." | ( Bruera, E; Gagnon, B, 1999) |
| "Pharmacological treatments for pain have come largely from two classes of compounds--the opioids and the nonsteroidal anti-inflammatory drugs (NSAIDs)." | ( Decker, MW; Meyer, MD, 1999) |
| "Adequate treatment of cancer pain remains a significant clinical problem." | ( Blumberg, PM; Iadarola, MJ; Olah, Z; Szabo, T, 1999) |
| "These results identify a target for treating persistent pain and suggest that the small population of SPR-expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain." | ( Allen, BJ; Finke, MP; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Luger, NM; Mantyh, PW; Nichols, ML; Rogers, SD; Simone, DA, 1999) |
| "Apart from short-term effects, untreated pain and stressful stimuli may also have long-term effects, which may later affect their neurological development, including the reaction to pain." | ( Larsson, BA, 1999) |
| "is effective and safe in the treatment of pain and fever in children." | ( Izhar, T, 1999) |
| "For this reason, the treatment of acute pain induced by this pathology is still a clinically important issue." | ( Balestra, V; Monteforte, P; Rovetta, G, 2000) |
| "They can be used alone for the treatment of mild pain or as an adjunct to opioid analgesia." | ( Tobias, JD, 2000) |
| "Unfortunately, the treatment of pain has remained secondary to the diagnosis and treatment of the disease state." | ( Schechter, NL; Zempsky, WT, 2000) |
| "As a treatment for pain EMDR offers a method of facilitating permanent changes in how pain is experienced somatically and emotionally." | ( Grant, M, 2000) |
| "Before and at the end of each treatment period, pain and sensitivity were also assessed by using the McGill Pain Questionnaire, allodynia to touch, brush and cold, wind-up-like pain, and thresholds to mechanical stimuli (pressure and von Frey hair)." | ( Gottrup, H; Jensen, TS; Kristensen, AG; Nikolajsen, L, 2000) |
| "Retrospective analyses of headaches treated during mild pain were performed using data from 3 studies of sumatriptan tablets (protocols S2CM09, S2BT25, and S2BT26)." | ( Cady, RK; Crisp, A; Jones, M; Lipton, RB; McNeal, S; Metz, A; O'Quinn, S; Putnam, DG; Sheftell, F, 2000) |
| "The standard pillar of postoperative treatment of severe pain is the use of opioids." | ( Dahl, V; Raeder, JC, 2000) |
| "Bisphosphonate treatment of painful osseous metastases due to hormone refractory prostate cancer results in a significant pain decrease and a significant decrease in the daily consumption of analgesics in 75% of patients." | ( Engelmann, UH; Heidenreich, A; Hofmann, R, 2001) |
| "In addition to treating the pain per se, attention should be given to prevention of disease progression and exacerbation, as maintaining function is of prime importance." | ( Hanlon, JT; Weiner, DK, 2001) |
| "If untreated, the pain of circumcision causes both short and long term changes in infant behaviours." | ( Taddio, A, 2001) |
| "However, initiating treatment while pain is mild may be more cost-effective than delaying treatment until pain has become moderate to severe." | ( Cady, RK; Kwong, WJ; Lipton, RB; O'Quinn, S; Sheftell, F, 2001) |
| "As well as acute treatment of severe pain, a significant number of respondents reported treating patients prophylactically, and the majority thought that their use of bisphosphonates would increase over the next 2 years." | ( Johnson, IS, 2001) |
| "When treating pain, gender and racial differences were evident only when the role of physician gender was examined, suggesting that male and female physicians may react differently to gender and/or racial cues." | ( Sanders, KN; Sorum, PC; Syat, BL; Weisse, CS, 2001) |
| "Barriers to the treatment of pain are associated with health care providers and the patients themselves." | ( Breitbart, W; Lefkowitz, M; Levin, J, 1995) |
| "Currently, the treatment of bone pain remains palliative at best with systemic therapy (analgesics, hormones, chemotherapy, steroids, and bisphosphonates) as well as local treatments (such as surgery, nerve blocks, and external beam radiation)." | ( Serafini, AN, 2001) |
| "At the end of treatment, pain relief was significantly greater in patients treated with disodium-clodronate." | ( Maggiani, G; Molfetta, L; Monteforte, P; Rovetta, G, 2001) |
| "Undertreatment of pain is a persistent clinical problem for patients with cancer." | ( Dohi, S, 2001) |
| "To examine the treatment of pain in endometriosis by buserelin acetate implants." | ( Choktanasiri, W; Rojanasakul, A, 2001) |
| "The factors contributing to undertreated pain in the clinical setting are considered, as well as the hazards posed by recent failures to address ethically questionable clinical practices." | ( Rich, BA, 1997) |
| "Agents with little activity in the treatment of acute pain, such as antidepressants, antiepileptics, and i." | ( Eisenach, JC; Martin, TJ, 2001) |
| "private practice) and treatment of cancer pain patients during the last three months shows a better result for GPs (84." | ( Bautz, MT; Ensink, FB; Görlitz, A; Hanekop, GG; Voss, MC, 2002) |
| "The magnesium-lignocaine treatment was painful in 52% of patients compared with 8% with lignocaine alone (number-needed-to-harm 2." | ( Glynn, CJ; Tramèr, MR, 2002) |
| "Effective therapies are available to treat pain." | ( Li, JM, 2002) |
| "Bisphosphonate treatment of painful osseous metastases due to HRPCA resulted in a significant pain reduction and a significant decrease of daily consumption of analgesics in 92% of the patients." | ( Elert, A; Heidenreich, A; Hofmann, R, 2002) |
| "Cognitively intact patients with undertreated pain were nine times more likely to develop delirium than patients whose pain was adequately treated." | ( Gilbert, M; Koval, KJ; Magaziner, J; McLaughlin, MA; Morrison, RS; Orosz, G; Siu, AL; Strauss, E, 2003) |
| "Current symptomatic treatments for painful peripheral neuropathy in diabetes have variable efficacy in individual patients." | ( Amin, P; Sturrock, ND, 2003) |
| "Gabapentin was effective in the treatment of painful diabetic neuropathy, postherpetic neuralgia, and other neuropathic pain syndromes." | ( Backonja, M; Glanzman, RL, 2003) |
| "To develop a genetic approach for the treatment of pain, we introduced a recombinant adeno-associated viral (rAAV) vector containing the cDNA for the mu-opioid receptor (muOR) into primary afferent neurons in dorsal root ganglia (DRGs) of rats, which resulted in a long-lasting (>6 months) increase in muOR expression in DRG neurons." | ( Gu, Y; Huang, LY; Li, GW; Wu, P; Xu, GY; Xu, Y, 2003) |
| "(1) For the treatment of cancer pain resistant to WHO step I and II analgesics, several oral morphine preparations are available, in immediate-release and sustained-release formulations." | ( , 2003) |
| "On the other hand, untreated severe pain has a high risk potential, since it may reduce both cognitive and psychomotoric performance." | ( Sohn, W, 2003) |
| "Around half of patients in both treatments had a pain intensity <30 mm on VAS at the end of treatment (55% for dexketoprofen and 47% for ketorolac)." | ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| "In patients undergone doxazosin treatment; symptom, pain and quality of life status revealed 32." | ( Burgut, R; Evliyaoğlu, Y, 2002) |
| "(AR) has been used to treat pain and inflammation in Korea." | ( Gao Zhang, C; Kim, SJ; Taek Lim, J, 2003) |
| "Although our ability to treat persistent painful conditions, such as chronic inflammatory and neuropathic pain, has improved in recent years, these conditions are often resistant to currently available therapies, such as opioids or non-steroidal anti-inflammatory drugs." | ( Assis, TS; Currie, AJ; Kennedy, C; Rowan, EG, 2003) |
| "For a modern approach to the treatment of pain, a new form of communication that puts emphasis on the need for empathy with the patient is indispensable." | ( Sohn, W, 2003) |
| "Preterm infants undergoing untreated, repeated painful procedures as part of their early experience are more likely to behave differently to pain as they mature than infants who were born at term and did not experience excessive exogenous pain." | ( Johnston, CC; Walker, CD, 2003) |
| "Using a post treatment global pain assessment, a positive clinical response was observed in 62." | ( Abdel-Rahman, SM; Andre, L; Friesen, CA; Kearns, GL; Neustrom, M; Roberts, CC, 2004) |
| "The use of venlafaxine for treatment of pain associated with MDD or GAD, neuropathic pain, headache, fibromyalgia, and postmastectomy pain syndrome is reviewed." | ( Albano, D; Grothe, DR; Scheckner, B, 2004) |
| "Prevention and treatment of pain is a basic human right, regardless of age, and if the technique of fetal surgery is to progress then a greater understanding of nociception and the stress response is required." | ( White, MC; Wolf, AR, 2004) |
| "Recent studies have demonstrated that untreated pain can have long-term effects on infant pain behaviours months beyond the events, thus, opioid analgesics may have a beneficial role that extends beyond the immediate painful event(s)." | ( Katz, J; Taddio, A, 2004) |
| "A particular problem in the treatment of cancer pain is the suddenly occurring stress and perforation pain." | ( Thoma, R; Winter, E, 2004) |
| "The number needed to treat for 50% pain relief was 3." | ( Bach, FW; Jensen, TS; Svendsen, KB, 2004) |
| "The public health crisis of under treated pain parallels medicine's struggle to adequately classify Pain Medicine as a specialty." | ( Carr, DB; Fishman, SM; Gallagher, RM; Sullivan, LW, 2004) |
| "The effective treatment of severe pain requires a multimodal approach with a thorough knowledge of the pharmacological properties of the individual drugs." | ( Gerber, H, 2004) |
| "Corticosteroids are rarely used in the treatment of pain in the course of GBS, although some authors have pointed out their value for the treatment of neuropathic pain." | ( Boukhris, S; Kabore, R; Lacoste, M; Mabrouk, T; Magy, L; Vallat, JM, 2004) |
| "To examine the prevalence of the undertreatment of pain, particularly among African Americans, and to recommend relevant proactive policy and practice changes to aid in eliminating this health problem." | ( Benjamin, L; Clark, W; Dennis, GC; Keough, K; Leak, WD; Payne, R; Perez, L; Primm, BJ; Smith, D; Sullivan, LW, 2004) |
| "TSE has been used to treat pain and may improve limb blood flow." | ( Simpson, KH; Ward, J, 2004) |
| "A good to very good effect of the treatment on the pain was reported by 45% of the patients, and only 25% reported an unsatisfactory effect." | ( Kohnen, R; Müller, W; Tolk, J, 2004) |
| "Drugs are the mainstay of treatment." | ( Mercadante, S, 2004) |
| "All were already treated for their pain syndrome." | ( Body, JJ; Lossignol, DA; Plehiers, B, 2004) |
| "The evaluated palliative treatments were pain medication only, chemotherapy consisting of mitoxantrone and prednisone, and single- and multifraction radiotherapy (RT)." | ( Konski, A, 2004) |
| "NSAIDs are widely applied to treat cancer pain and are frequently combined with opioids in combination preparations for this purpose." | ( Carr, DB; Goudas, L; Lau, J; McNicol, E; Strassels, SA, 2005) |
| "To improve our treatment of pain in the ED, a fundamental change in attitude toward pain and the control of pain is required." | ( Barton, ED; Fosnocht, DE; Swanson, ER, 2005) |
| "Antidepressants are often used to treat neuropathic pain." | ( Goto, F; Koizuka, S; Nishikawa, K; Obata, H; Saito, S, 2005) |
| "The number needed to treat to prevent pain was 5." | ( Chong, SY; Goh, MH; Tan, KH; Yew, WS, 2005) |
| "Those who dropped out were considered treatment failures." | ( Failde, I; Micó, JA; Muriel, C; Neira, M; Sánchez-Magro, I, 2005) |
| "With respect to the treatment of pain, topical CB1 agonists and CB2 agonists may prove therapeutically useful, and there is evidence that the non-steroidal inflammatory agent indomethacin produces effects secondary to activation of the endocannabinoid system." | ( Fowler, CJ; Holt, S; Jacobsson, SO; Jonsson, KO; Nilsson, O; Tiger, G, 2005) |
| "Historically, children have been undertreated for their pain, and they continue to undergo painful cutaneous procedures without analgesics." | ( Koren, G; Schuh, S; Scolnik, D; Soin, HK; Taddio, A, 2005) |
| "A sufficient treatment of pain requires knowledge of the pathomechanism of pain and of the basics of pain management in cancer patients." | ( Harzmann, R; Weckermann, D, 2005) |
| "Patients further treated in the pain clinic stopped significantly less frequently than patients treated by GPs or other non-specialised physicians (5 versus 23%)." | ( Maier, C; Schaub, C; Willweber-Strumpf, A; Zenz, M, 2005) |
| "The use of morphine for the treatment of pain is sometimes accompanied with side effects such as emesis, constipation and drowsiness." | ( Narita, M; Niikura, K; Ozaki, M; Suzuki, T; Yajima, Y, 2005) |
| "Glucocorticoids have been used to treat neuropathic pain for many years, but the underlying mechanisms are still unknown." | ( Liu, X; Luo, S; Xie, W; Xu, J; Xuan, H; Zhao, X; Zhou, Z, 2006) |
| "One of the most difficult to treat cancer pains is metastatic invasion of the skeleton that can generate ongoing and bone breakthrough pain, which represents one of the most debilitating cancer-related events." | ( Ghilardi, JR; Halvorson, KG; Kubota, K; Lindsay, TH; Mantyh, PW; Sevcik, MA, 2005) |
| "Opioids are increasingly often used to treat muscle pain." | ( Grass, S; Graven-Nielsen, T; Schulte, H; Segerdahl, M, 2006) |
| "Undertreatment of acute pain is suboptimal medical treatment, and patients receiving long-term OAT are at particular risk." | ( Alford, DP; Compton, P; Samet, JH, 2006) |
| "We have used 89SrCl2 for the palliative treatment of painful bone metastases from various malignant diseases." | ( Fang, N; Fu, P; Gao, FT; Gao, HQ; Li, Y; Ma, D; Xu, YS; Yang, HS; Yang, ZJ, 2006) |
| "Compared with no treatment, pain scores were lower in the morphine and tetracaine-morphine groups during skin preparation (mean difference, -0." | ( Lee, C; McNamara, PJ; Parvez, B; Shah, V; Taddio, A; Yip, A, 2006) |
| "When undertreated, pain usually results in serious immune and metabolic upset." | ( Al Malyan, M; Ashammakhi, N; Becchi, C; Boncinelli, S; Chiellini, F; Nikkola, L; Viitanen, P, 2006) |
| "Although PDT is a well-tolerated treatment, pain is the most severe side effect." | ( Hein, R; Kasche, A; Luderschmidt, S; Ring, J, 2006) |
| "Appropriate and timely treatments of painful conditions result in maximum function and the ability to lead active lives and maintain an adequate quality of life." | ( Gassaway, JA; Horn, SD; Smout, RJ; Zorowitz, RD, 2005) |
| "Many barriers exist in treating chronic pain, especially when treating with opioid analgesics." | ( Wallace, JM, 2006) |
| "A greater emphasis on the impact of treatment on pain and healing is warranted both clinically and in research." | ( Briggs, M; Closs, SJ, 2006) |
| "It has been approved for the treatment of pain in diabetic neuropathy." | ( Hajak, G, 2006) |
| "Therefore, an adequate evaluation and treatment of pain is crucial." | ( Baron, C; Fromy, B; Leftheriotis, G; Roquelaure, Y; Saumet, JL; Sigaudo-Roussel, D, 2007) |
| "Opioid treatment of pain has been, and remains, severely hampered because of actual and legal constraints related to addiction risk." | ( Ballantyne, JC, 2006) |
| "Attitudes towards treating the pain of cancer patients and elderly patients are positive." | ( Kalso, E; Niemi-Murola, L; Nieminen, JT; Pöyhiä, R, 2007) |
| "The use of systemic corticosteroids to treat pain in children with arthritis should be avoided." | ( Kimura, Y; Walco, GA, 2007) |
| "Transdermal fentanyl is efficient in treating chronic pain of cancer, and also can relieve the severe pain of mucositis resulted from chemotherapy." | ( Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Lin, XB; Peng, YL; Wang, BF, 2007) |
| "When planning the VSPL in the treatment of pain in patients suffering from chronic pancreatitis, it is necessary to take into consideration the previous chronic use of opioids, as this variable can significantly influence poorer results of this surgical pain management." | ( Kaska, L; Kobiela, J; Kwiecińska, B; Lachinski, AJ; Makarewicz, W; Sledziński, Z; Stanek, A; Stefaniak, T; Vingerhoets, A, 2008) |
| "DM has been found to be useful in the treatment of pain in cancer patients and in the treatment of methotrexate-induced neurotoxicity." | ( Drachtman, R; Siu, A, 2007) |
| "Opioid treated chronic pain patients with insufficient pain relief may benefit from conversion to methadone, as 59% in our analysis achieved better pain relief, while the rotation was generally opioid-saving at the same time." | ( Bendiksen, A; Handberg, G; McGehee, E, 2007) |
| "It is challenge to assess and treat pain in premature infants." | ( Areco, KC; Balda, Rde C; dos Santos, AM; Guinsburg, R; Peres, CA; Serpa, AB, 2007) |
| "In episodes treated with IV-MO, pain intensity decreased from a mean of 6." | ( Casuccio, A; Ferrera, P; Intravaia, G; Mangione, S; Mercadante, S; Villari, P, 2007) |
| "NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e." | ( Berger, TM; Jöhr, M; Ruesch, S, 2007) |
| "Premature infants experience untreated repetitive pain that may alter their brain development." | ( Anand, KJ; Bhutta, AT; Garg, S; Hall, RW; Narsinghani, U; Rovnaghi, CR, 2007) |
| "Strategies for treating arthritic pain are therefore different from those adopted for acute pain." | ( Kidd, BL; Langford, RM; Wodehouse, T, 2007) |
| "has been utilized for treatment of pain and sleep disorders since ancient times." | ( Guy, GW; Robson, PJ; Russo, EB, 2007) |
| "The most common treatment of cancer pain consists of the use of regularly given oral analgesics." | ( Arcuri, E; Mercadante, S, 2007) |
| "The main adverse effect in PDT treatment is pain." | ( Brogaard, HM; Jemec, GB; Lindeburg, KE, 2007) |
| "The model assigned untreated pain scores over 84 days." | ( Díaz, S; Dukes, E; Rejas, J; Rodríguez, MJ; Vera-Llonch, M, 2007) |
| "fentanyl for the treatment of acute pain in children." | ( Biros, MH; Herold, M; Hubbard, D; Kletti, C; Miner, JR, 2007) |
| "To describe the treatment of knee pain in older adults in primary care and to compare reported practice with published evidence." | ( Croft, P; Jinks, C; Jordan, K; Porcheret, M, 2007) |
| "Three core treatments for knee pain (written information, exercise and weight loss) were advised to 16%, 46% and 39% of the participants, respectively." | ( Croft, P; Jinks, C; Jordan, K; Porcheret, M, 2007) |
| "Interventions recommended as core treatment for knee pain in older adults were underused-in particular, exercise, weight loss and the provision of written information." | ( Croft, P; Jinks, C; Jordan, K; Porcheret, M, 2007) |
| "This study demonstrates that treatment of painful HIV-associated neuropathy with a single application of NGX-4010, a high-concentration capsaicin patch, was feasible, well tolerated, and associated with significant reduction in pain over the 12 weeks studied." | ( Brown, SJ; Estanislao, L; Sampson, J; Simpson, DM, 2008) |
| "Failure to treat acute pain aggressively may lead to chronic pain syndrome." | ( Ballas, SK, 2007) |
| "Analgesics are required to prevent and treat postpartum pain, but breast-feeding may be contraindicated, because data on milk transfer are very limited." | ( Boissinot, C; Jacqz-Aigrain, E; Michel, J; Popon, M; Serreau, R; Sibony, O; Sobel, A, 2007) |
| "Clinicians treating pain should be familiar with the actions, adverse effects, and individual agents in the group of nonopioid analgesics." | ( Enany, N; Munir, MA; Zhang, JM, 2007) |
| "We assessed the pretreatment pain and discomfort after the intradermal skin injection using a 100-mm visual analogue scale." | ( Chung, SP; Lee, HS; Park, YS; Yoon, WY, 2008) |
| "The under treatment of cancer pain is still a major issue in both oncology and palliative medicine." | ( Cleary, JF, 2007) |
| "It covers identification and treatment of pain and other physical symptoms, psychological, social, and spiritual difficulties." | ( Wieland, T, 2007) |
| "Reports that prior acute morphine treatment and pain could influence tolerance mechanisms were not understood on mechanistic levels and, consequently, were not incorporated into commonly used models of opioid tolerance." | ( Chakrabarti, S; Gintzler, AR, 2008) |
| "After IV cannulation by the treating nurse, the pain of cannulation was measured on a validated 100-mm visual analogue scale or Wong Baker scale." | ( Chipley, J; Chisena, EN; Gupta, N; Singer, AJ; Taira, BR, 2008) |
| "The continued need for opioids to treat pain and their unavoidable link to abuse and addiction create a need for risk mitigation approaches that optimize their risk-benefit ratio." | ( Katz, N, 2008) |
| "The challenge is not in treating pain, but identifying true pain from drug-seeking behaviors." | ( Dewey, CM; Mitchell, AM, 2008) |
| "Increased awareness of how to treat cancer pain is important go give a good treatment offer to all in Norway." | ( Olsen, AS; Ottesen, S, 2008) |
| "Following a transient treatment-related pain increase, pain was reduced; significant improvement was apparent by week 2 and continued throughout the controlled 12-week observation period." | ( Brown, S; Simpson, DM; Tobias, J, 2008) |
| "Amitriptyline is used to treat neuropathic pain in humans." | ( Fredholm, BB; Reid, AR; Sawynok, J, 2008) |
| "Ten patients with symptomatic MM were treated to achieve pain control." | ( Abruzzese, E; Di Maio, M; Iuliano, F; Trawinska, MM, 2008) |
| "Yokuininto was effective in treating burning pain in both lower legs of a 58-year-old woman." | ( Kanai, M; Kawagoe, I; Mitsuhata, H; Tajima, K, 2008) |
| "The undertreatment of pain has increasingly been framed as both a public health problem and a human rights issue." | ( Bell, K; Salmon, A, 2009) |
| "Morphine is widely used to treat chronic pain, however its utility is hindered by the development of tolerance to its analgesic effects." | ( Ko, SW; Quan, J; Shum, F; Wu, LJ; Zhuo, M, 2008) |
| "This is a case report of a CPP treated by a pain physician." | ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009) |
| "The pathophysiology, diagnosis, and treatment of pain and mood disorders are discussed in this video, which features case studies of and expert commentary on patients with diabetic neuropathy, lower back pain, and chronic widespread pain." | ( Arnold, LM; Glazer, WM; Jain, R, 2008) |
| "There was no difference in the treatments used or pain relief achieved between migraine, migrainous, and tension-type headaches." | ( Miner, J; Trainor, A, 2008) |
| "The average treatment levels of pain did not differ, hence, the average mediated effect of treatment on GHRQL was zero." | ( Donaldson, GW; Moinpour, CM; Nakamura, Y, 2009) |
| "This drug may be useful to treat pain syndromes in humans." | ( Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO, 2009) |
| "Patients often treat their pain with over-the-counter NSAIDs." | ( Lysz, T; O'Connor, JP, 2008) |
| "Providers treating pain and co-morbid addiction described ambiguity in all diagnostic and therapeutic decisions." | ( Arnsten, JH; Berg, KM; Karasz, A; Sacajiu, G, 2009) |
| "Across Europe and Israel, treatment of cancer pain is suboptimal." | ( Breivik, H; Cherny, N; Cohen, R; Collett, B; de Conno, F; Dow, L; Filbet, M; Foubert, AJ, 2009) |
| "Under-treatment of pain is frequently reported, especially among seniors, with chronic non-cancer pain most likely to be under-treated." | ( Carrie, AG; Grymonpre, RE; Metge, CJ; Sadowski, CA; St John, P, 2009) |
| "Improvements were comparable between treatments in painful DPN." | ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "We implemented guidelines for treatment of pain in our emergency department (ED) and tracked the major analgesics used in this ED to monitor trends in pain management over a decade." | ( Brill, S; Halpern, P; Hertz, D; Meissner, W; Or, J; Zaslansky, R, 2010) |
| "With this method of treatment, venous pain and phlebitis developed in 14 of 15 cases." | ( Andou, K; Harada, M; Ikeda, T; Ishikawa, M; Kamo, N; Matsui, M; Moriyama, N; Ono, C; Sugimoto, M; Yamamoto, M; Yamaoka, H; Yamaoka, K; Yamauchi, Y, 2009) |
| "To develop better treatments for pain-centered fibromyalgia symptoms, there is still a need for animal models which mimic the features of fibromyalgia patients." | ( Aoki, T; Matsuoka, N; Nagakura, Y; Oe, T, 2009) |
| "Evaluate the efficiency of the treatment of pain by analgesic according to World Health Organization (WHO)." | ( Coulibaly, Y; Dembele, A; Diakite, AA; Dicko-Traore, F; Keita, MM; Sidibe, T; Sylla, M; Togo, B; Traore, B, 2009) |
| "The efficiency of the treatment by painkiller was evaluated at second hour and at the 24 hour." | ( Coulibaly, Y; Dembele, A; Diakite, AA; Dicko-Traore, F; Keita, MM; Sidibe, T; Sylla, M; Togo, B; Traore, B, 2009) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| "The accurate assessment and effective treatment of acute pain in children in the hospital setting is a high priority." | ( Kraemer, FW; Rose, JB, 2009) |
| "When considering opiates as a treatment option, pain clinics should have a heightened suspicion for younger and unemployed patients." | ( Dillingham, TR; González-Fernández, M; Rothfield, L; White, KT, 2009) |
| "speciosa for treating pain and inflammation." | ( Chen, WS; Li, X; Sun, LN; Yang, Q; Yang, YB, 2009) |
| "Opioids have been used to treat chronic pain originating from knee osteoarthritis and the lower back; however, several side effects have been reported." | ( Eguchi, Y; Endo, M; Ohtori, S; Orita, S; Suzuki, M; Takahashi, K; Yamashita, M; Yamashita, T; Yamauchi, K, 2009) |
| "However, effective treatment for such pain is limited and often associated with high placebo effects." | ( Chang, FY; Cheng, CM; Hsieh, JC; Lee, SD; Lu, CL; Lu, HC; Niddam, DM; Wu, YT; Yeh, TC, 2010) |
| "The mean pretreatment pain score was 6." | ( Burgoyne, CC; Giglio, JA; Laskin, DM; Reese, SE; Sima, AP, 2010) |
| "Novel approaches for treating chronic pain are required to address a widely recognized, yet largely underserved and unmet, clinical need." | ( Blagg, J; Hopkins, AL; Naylor, AM; Pojasek, KR, 2010) |
| "The only patient who was treated for flank pain did not complain of pain up to 1-year follow-up." | ( Gamanagatti, S; Mukund, A, 2010) |
| "After JCM-16021 treatment, the pain threshold pressure significantly increased when compared to that before treatment (34." | ( Bian, ZX; Han, QB; Sung, JJ; Xu, HX; Zhang, M, 2010) |
| "Physicians who treat chronic pain must utilize strategies to minimize the risk of developing dependence on opioids, and practitioners treating opioid dependence must employ policies to optimize outcomes." | ( Jan, SA, 2010) |
| "Milnacipran is an effective and safe treatment for pain and other predominant symptoms of FM." | ( Branco, JC; Mainguy, Y; Perrot, S; Zachrisson, O, 2010) |
| "mays husk decoction for the treatment of pain and inflammatory conditions in Nigerian folk medicine." | ( Ibidapo, AJ; Negedu, MN; Oguntoye, SO; Olaniran, SO; Onasanwo, SA; Owoyele, BV; Oyeleke, SA; Sanya, JO; Soladoye, AO, 2010) |
| "To discover analgesics for treating chronic pain 17 novel Schiff's bases, N,N'-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters." | ( Li, C; Peng, L; Peng, S; Wu, J; Wu, Y; Zhao, M; Zheng, M; Zhou, Y, 2010) |
| "Effective treatment of pain improves the overall quality of life." | ( Finco, G; Lussier, D; Richarz, U, 2010) |
| "In the treatment of pain management, physicians employ a variety of drugs, ranging from low-impact to highly potent, and to maximize patient health, urine toxicology analyses can significantly improve the delivery of pain treatment." | ( Chen, IL; Gudin, MT; Kodumudi, V; Ortigosa, E; Vadivelu, N, 2010) |
| "Analgesics currently available for the treatment of pain following ophthalmic surgery or injury are limited by transient effectiveness and undesirable or adverse side effects." | ( Bates, BD; Chan, CC; Iadarola, MJ; Keller, JM; Mannes, AJ; Mitchell, K; Swaim, WD; Yaskovich, R, 2010) |
| "As untreated pain in infancy has both immediate and longer-term negative consequences, such as increased sensitivity and responses to subsequent pain, it is imperative that widespread sustained practice changes are made to reduce the burden of pain." | ( Harrison, D; Stevens, B; Yamada, J, 2010) |
| "MAL was applied 3 h before light treatment." | ( Abuzahra, F; Braathen, LR; Hoff-Lesch, S; Hoffmann, G; Merk, HF; Renn, CN; von Felbert, V, 2010) |
| "Undertreated pain and prescription opioid abuse remain important public health problems." | ( Fine, PG; Webster, LR, 2010) |
| "Eight hours after treatment the mean pain +/- SEM in all locations was reduced significantly (P < ." | ( Denk, K; Enk, A; Gholam, P; Hartmann, M; Sehr, T, 2010) |
| "For the treatment of painful OA flare-ups, the etodolac-paracetamol combination can offer improved clinical outcomes by targeting multiple pain pathways." | ( Ambade, R; Bartakke, G; Chandanwale, A; Chandurkar, N; Pareek, A, 2010) |
| "Although opioids are commonly used to treat pain, dyspnea, and other symptoms at the end of life, little information is available on the safety and efficacy of the use of these medications in terminally ill patients in the home care setting." | ( Bengoechea, I; Gutiérrez, SG; Lopez, JM; Onaindia, MJ; Vrotsou, K, 2010) |
| "Bromfenac was effective in treating pain associated with infectious keratitis and did not delay corneal epithelialization nor cause any corneal adverse events in this group of 25 eyes." | ( Schechter, BA; Trattler, W, 2010) |
| "The frequency, cause and treatment of limb pain were ascertained in a cohort of children at six time points between the ages of 5 and 13 years." | ( Bishop, JL; Emmett, PM; Golding, J; Northstone, K, 2012) |
| "Studies indicate that treatment of acute pain remains suboptimal due to attitudes and educational barriers on the part of both physicians and patients, as well as the intrinsic limitations of available therapies." | ( Sinatra, R, 2010) |
| "Therapies directed toward the treatment of pain should be mechanism based and preventative whenever possible." | ( Muir, WW, 2010) |
| "Oxycodone is widely used for the treatment of cancer pain, but little is known of its pharmacokinetics in cancer pain patients." | ( Andreassen, TN; Bjordal, K; Dale, O; Davies, A; Kaasa, S; Klepstad, P; Lundström, S, 2011) |
| "RCTs of GnRHas as treatment for pain associated with endometriosis versus no treatment, placebo, danazol, intra-uterine progestagens, or other GnRHas were included." | ( Brown, J; Hart, RJ; Pan, A, 2010) |
| "Pediatric neurologists frequently treat acute pain in children." | ( Kraemer, FW, 2010) |
| "In spite of improvements in wound treatment and pain regimens during recent years, the management of burn pain still remains a common problem and a tremendous challenge for clinical staff." | ( Girtler, R; Gustorff, B, 2011) |
| "One tool for treating pain is opioid therapy, and opioid prescriptions have increased dramatically in recent years in the United States." | ( Lewis, ET; Trafton, JA, 2011) |
| "Although opioid analgesics treat more types of pain and are usually more potent than other classes of analgesics, opioids are ineffective for some patients and can cause adverse physiologic or psychiatric effects in others." | ( Fishman, SM, 2011) |
| "Physiopathological mechanisms and treatment of pain remain a significant challenge." | ( Distrutti, E, 2011) |
| "Although opioids can treat pain, prescribers must consider the consequences of iatrogenic or missed addiction diagnoses." | ( Botsko, M; Boverman, J; Egan, JE; Fiellin, DA; Hersh, D; Little, S; Lum, PJ; Mitty, J; Thawley, RE, 2011) |
| "Opioid agonists are the most effective treatment for pain, but their use is limited by side effects, tolerance and fears of addiction and dependence." | ( Christie, MJ; Morgan, MM, 2011) |
| "Negative impacts of untreated pain on patient activities of daily living and public health expenditures, combined with the success of opioid analgesics in treating pain provide a strong rationale for PCPs to learn best practices for pain management." | ( McCarberg, BH, 2011) |
| "Chronic treatment of pain with opiate drugs can lead to analgesic tolerance and drug dependence." | ( Enquist, J; Ferwerda, M; Milan-Lobo, L; Whistler, JL, 2012) |
| "To validate its folk use in the treatment of pain, wood was extracted successively with petroleum ether, chloroform, ethyl acetate, ethanol, and water to produce respective extracts." | ( Bairagi, JH; Mandal, SC; Nirmal, SA; Pal, SC; Patil, AN; Upasani, CD, 2012) |
| "minor improvement, P = 0·007) than PDT-treated skin." | ( Anderson, RR; Haak, CS; Hædersdal, M; Hædesdal, M; Thaysen-Petersen, D; Togsverd-Bo, K; Wulf, HC, 2012) |
| "The consequences of inadequately treated pain are physiological and psychological effects on the patient, as well as socioeconomic implications." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "The pretreatment pain intensity score mean (+ SD) was 8." | ( Ajayi, IO; Akinyemi, OA; Elumelu, TN; Eyelade, OR; Soyannwo, OA, 2012) |
| "Under-treatment of pain remains a major concern in community-dwelling or institutionalized older persons, especially with dementia." | ( Pickering, G, 2012) |
| "crassifolius for the treatment of pain and inflammation." | ( Fang, F; Wang, G; Yang, L; Yu, L; Zhao, J, 2012) |
| "cordifolia was mainly used for treating pain and wounds." | ( Austarheim, I; Diallo, D; Inngjerdingen, KT; Khaledabadi, M; Mahamane, H; Michaelsen, TE; Paulsen, BS; Sanogo, R; Togola, A; Vestrheim, AC, 2012) |
| "For providers who treat pain, this has led to clinical dilemmas as the newly appreciated risks must be balanced with the benefits of treatment, particularly in patients with known substance use disorders." | ( Ballantyne, J; Krashin, D; Murinova, N, 2012) |
| "Improved awareness, assessment, and treatment of pain result in better care and overall patient outcome." | ( Bendo, AA; Lai, LT; Ortiz-Cardona, JR, 2012) |
| "Potential therapeutic targets to treat pain are described." | ( Hargreaves, KM; Henry, MA; Loyd, DR, 2013) |
| "While all have the goal of treating pain while mitigating misuse and abuse, there are different technologies utilized to impart the abuse-deterrent properties." | ( Schaeffer, T, 2012) |
| "The symptomatic treatment of pain associated with spasm of gastrointestinal or genitourinary origin can include the use of spasmolytic agents and/or non-steroidal anti-inflammatory drugs." | ( del Valle-Laisequilla, CF; Flores-Murrieta, FJ; Granados-Soto, V; Reyes-García, G; Rocha-González, HI, 2012) |
| "Radioisotopes have been used for treatment of painful bony metastases." | ( Croke, J; Leung, E; Malone, S; Segal, R, 2012) |
| "Pretreatment and posttreatment pain intensities were quantified by the verbal numeric rating scale (NRS) from 0 to 10." | ( Fowler, M; Kotwal, RS; McGhee, L; McManus, JG; Pennardt, A; Talbot, TS; Wedmore, IS, 2012) |
| "Post hoc analysis showed that the treatment reduced pain scores by -44% (95% CI -57%, -26%) compared with placebo, and it also increased the pressure pain threshold by 39% (95% CI 14%, 54%)." | ( Caumo, W; Custódio de Souza, IC; Fregni, F; Torres, IL; Vidor, LP, 2013) |
| "Further education of physicians who treat chronic pain pharmacologically is warranted." | ( Avram, MJ; Benzon, HA; Benzon, HT; Cox, P; Dean, K; Katz, JA; Kendall, MC; Malik, K, 2013) |
| "Opioid rotation is used to treat uncontrolled pain and/or opioid-related adverse effects." | ( Bruera, E; Frisbee-Hume, S; Kwon, JH; Palla, SL; Pulivarthi, K; Reddy, A; Wang, X; Yennurajalingam, S, 2013) |
| "Of all drug use to treat MS symptoms, treatment for pain accounts for nearly 30 % of total use." | ( Messmer Uccelli, M; Solaro, C; Trabucco, E, 2013) |
| "Historically, fentanyl has been used to treat breakthrough pain because it is a very potent analgesic with a rapid onset and short duration of action." | ( Bruera, E; Hwang, IC; Park, SM, 2014) |
| "Morphine is widely used to treat severe pain in neonatal intensive care unit patients." | ( Anand, KJS; de Graaf, J; Jebbink, LG; Tibboel, D; Valkenburg, AJ; van Dijk, M; van Lingen, RA; Weisglas-Kuperus, N; Wijnberg-Williams, B, 2013) |
| "To effectively treat pain, it must be detected and quantified using a validated assessment tool." | ( Gélinas, C; Hallman, M; Herr, DL; Joffe, AM; Puntillo, K, 2013) |
| "Inadequate treatment of painful conditions in children is a significant and complex problem." | ( Engels, JA; Lin, CW; Ortega, HW; Reid, S; Vander Velden, H, 2013) |
| "Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system." | ( Becker, JA; Filliol, D; Gardon, O; Gaveriaux-Ruff, C; Karchewski, L; Kieffer, BL; Matifas, A; Reiss, D; Weibel, R; Wood, JN, 2013) |
| "The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat." | ( Azevedo, MI; Brito, GA; de Albuquerque Ribeiro, R; Lima-Júnior, RC; Nogueira, RB; Pereira, AF; Rolim, FE; Vale, ML; Wong, DV, 2013) |
| "He was treated for acute pain crisis and community-acquired pneumonia with intravenous fluids, supplemental oxygen, and intravenous levofloxacin." | ( Baber, A; Foy, M; Uprety, D, 2014) |
| "The effectiveness of tramadol in treating pain associated with burns is unclear." | ( Arizpe, HM; Clifford, JL; Fowler, M; Garza, TH; Loyd, DR; Novak, J; Petz, LN; Slater, TM, 2014) |
| "Therefore, new approaches to the treatment of pain states are needed to address these problems." | ( Giri, AK; Hruby, VJ, 2014) |
| "Antidepressant drugs are used in the treatment of pain as an adjuvant or alone." | ( Erkoseoglu, I; Kadioglu, M; Kalyoncu, NI; Kesim, M; Pepeoglu, D; Yanik, MN; Yaris, E, 2014) |
| "Appropriate treatment of pain requires an understanding of the characteristics of pain, including the severity and the nature of the pain-for example, acute versus chronic pain or nociceptive versus neuropathic pain." | ( Nalamachu, S, 2013) |
| "A major concern in the treatment of acute pain/inflammation is the potential for drug-drug interactions resulting from P-gp induction by therapeutic agents co-administered with opioids." | ( Davis, TP; DeMarco, KM; Laracuente, ML; Ronaldson, PT; Sanchez-Covarrubias, L; Slosky, LM; Thompson, BJ; Zhang, Y, 2014) |
| "However, undertreatment of cancer pain has still been reported in Thailand." | ( Harun-Or-Rashid, M; Hirosawa, T; Sakamoto, J; Srisawang, P, 2013) |
| "Gabapentin, commonly used to treat neuropathic pain, produced increased NAc DA in rats with SNL but not in animals with incisional, injury." | ( Becerra, L; Borsook, D; Navratilova, E; Ossipov, MH; Patwardhan, A; Porreca, F; Qu, C; Xie, JY, 2014) |
| "For opioids used to treat cancer pain adverse event incidence rates were 25% for constipation, 23% for somnolence, 21% for nausea, 17% for dry mouth, and 13% for vomiting, anorexia, and dizziness." | ( Derry, S; Moore, RA; Wiffen, PJ, 2014) |
| "The genus Ajuga is used for the treatment of joint pain, gout, and jaundice in traditional Iranian medicine (TIM)." | ( Ardekani, MR; Davoodipoor, AM; Khanavi, M; Sadati, SN; Sharifzadeh, M, 2014) |
| "Opioid analgesics used to treat pain may cause sedation and respiratory depression by themselves." | ( Ward, CW, 2015) |
| "Multiple treatments for painful diabetic peripheral neuropathy are available." | ( Brito, JP; Carranza Leon, BG; Griebeler, ML; Montori, VM; Morey-Vargas, OL; Murad, MH; Phung, OJ; Tsapas, A; Wang, Z, 2014) |
| "Although opioids are used commonly to treat pain, psychiatric symptoms and inflammation also might be treatment targets in this population." | ( Bielefeldt, K; DiMartini, AF; Lotrich, FE; Rogal, SS; Szigethy, E; Wasan, AD; Zickmund, S, 2015) |
| "We used oxycodone hydrochloride to treat a sharp pain resulting from cataplectic cancer in the jejunal tube, but this provided only limited pain relief." | ( Baba, H; Fujimura, Y; Nakahara, O; Ohshima, S, 2015) |
| "The decision to treat pain in the emergency department (ED) is a complex, idiosyncratic process." | ( Armbrecht, E; Chauhan, V; Dalawari, P; Dickason, RM; Ibler, E; Kuehnle, S; Mahoney, D; Mor, A, 2015) |
| "The use of adjunctive treatments for pain may reduce opioid requirements and yield better outcomes." | ( Ballantyne, J; Jumelle, P; Krashin, D; Murinova, N, 2015) |
| "Opioids are used for the treatment of pain." | ( Drewes, AM; Gram, M; Graversen, C; Olesen, AE, 2015) |
| "Continuous morphine infusions (CMIs) treat pain and dyspnea at the end of life (EOL)." | ( Atayee, RS; Ching, A; Edmonds, KP; Lin, KJ; Ma, JD; Revta, C; Roeland, EJ, 2015) |
| "The pharmacological treatment of pain in CIA is strictly associated with the treatment of acute phases and flares of the disease, during which crystals trigger the inflammatory response." | ( Frallonardo, P; Galozzi, P; Lorenzin, M; Oliviero, F; Ortolan, A; Punzi, L; Ramonda, R; Scanu, A, 2015) |
| "Preventive AR786 treatment inhibited pain behaviour development and therapeutic treatment attenuated established pain behaviour." | ( Chapman, V; Mapp, PI; Nwosu, LN; Walsh, DA, 2016) |
| "Estimates of treatment efficacy (pain reduction, occurring in ∼57% of patients on all regimens) and toxicity (major cardiac or gastrointestinal toxicity or fractures, risk ranging from 1." | ( Collins, JE; Hunter, DJ; Jordan, JM; Katz, JN; Losina, E; Paltiel, AD; Smith, SR; Solomon, DH; Suter, LG; Yelin, E, 2016) |
| "The most frequent treatment was painkillers." | ( Berglund, J; Rennemark, M; Wranker, LS, 2016) |
| "One of the key issues in the treatment of pain is to choose the appropriate route and dosage form of analgesics for each individual patient in pain." | ( Kato, Y; Kubota, Y; Shimoyama, M; Shimoyama, N, 2015) |
| "The present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects." | ( Gul, F; Khan, H; Muhammad, N; Raziq, N; Saeed, M; Shahid, M, 2016) |
| "Rational personalized treatment of cancer pain can improve patient quality of life, relieve pain, and help prolong patient survival." | ( Dong, Y; Jiang, F; Yu, J; Zhang, B; Zhang, X; Zhou, T; Zhuang, F, 2016) |
| "To investigate the safe and effective treatment for painful venous malformation (VM) in limbs." | ( Huiping, C; Jie, Y; Miao, X; Tianxiang, O; Xiaorong, M; Yan, X; Yingying, H, 2015) |
| "Needed-to-treat was 4." | ( Banerjee, R; Gupta, R; Lakhtakia, S; Murthy, HV; Nageshwar Reddy, D; Pradeep, R; Ramchandani, M; Rao, GV; Talukdar, R; Tandan, M, 2016) |
| "After treatment, pain levels subsided, so that she was better able to tolerate dressing changes, could sleep in her own bed instead of a chair, and started compression therapy." | ( Simon, D, 2016) |
| "Prompt recognition, assessment, and treatment of pain are necessary, especially at the end of life." | ( Anghelescu, DL; Baker, JN; Ehrentraut, JH; Snaman, JM, 2016) |
| "The high efficacy of mydocalm in the treatment of pain syndromes with the muscle spasm has been demonstrated." | ( Baliazin, VA; Barantsevich, ER; Belova, AN; Bogdanov, EI; Danilenko, OA; Gafurov, BG; Galanov, DV; Guekht, AB; Guseinov, SG; Khabirov, FA; Lebedeva, AV; Miakotnykh, VS; Mishchenko, TS; Musaev, SK; Prokopenko, SV; Shprakh, VV; Shyralieva, RK; Skoromets, AA; Spirin, NN; Toktomushev, CT; Volkova, LI, 2015) |
| "Grapiprant treatment improved pain compared to placebo on day 28 (48." | ( Huebner, M; Rausch-Derra, L; Rhodes, L; Wofford, J, 2016) |
| "In response to the challenges of treating pain amid a prescription opioid epidemic, the American College of Emergency Physicians (ACEP) published an evidence-based clinical policy for opioid prescribing in 2012." | ( Barg, FK; Grossestreuer, A; Kilaru, AS; Meisel, ZF; Metlay, JP; Perrone, J; Rhodes, KV; Shofer, FS; Sinnenberg, L, 2016) |
| "To update our guidelines for the treatment of pain in patients with cancer, we performed a systematic review on the use of adjuvant analgesics in pain in cancer." | ( de Graeff, A; Dijkstra, D; Jongen, JL; Mostovaya, I; van den Beuken-van Everdingen, MH; Vissers, KC, 2017) |
| "The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects." | ( Malcangio, M; Pitcher, T; Sousa-Valente, J, 2016) |
| "Methadone offers many advantages for treating cancer pain." | ( Courtemanche, F; Dao, D; Gagné, F; Néron, A; Tremblay, L, 2016) |
| "Pregabalin has been used for the treatment of pain." | ( Kawakami, J; Naito, T; Yagi, T; Yoshikawa, N, 2016) |
| "Although persistent undertreatment of cancer pain is well documented, this study suggests that strategies for earlier pain assessment and initiation of strong opioid treatment in community-based patients with cancer could help to improve pain outcomes." | ( Bennett, MI; Blenkinsopp, A; Mulvey, M; Petty, D; Ziegler, L, 2016) |
| "NSAIDs are commonly prescribed for the treatment of pain and inflammation." | ( Miles, L; Mladsi, D; Odom, D; Ronquest, N; Saag, K, 2016) |
| "Opioids are the cornerstone for the treatment of acute pain in small animal patients." | ( Simon, BT; Steagall, PV, 2017) |
| "Opioids are widely used to treat severe pain." | ( Spahn, V; Stein, C, 2017) |
| "LESW treatment reduced pain behavior and downregulated the NGF expression (33." | ( Chuang, YC; Huang, CC; Lee, WC; Tyagi, P; Wang, HJ, 2017) |
| "Opioids are commonly employed to treat pain but must be approached with caution due to potentially dangerous adverse reactions." | ( Davies, PS, 2017) |
| "Kyphoplasty is frequently used for the treatment of painful osteoporotic fractures." | ( Grafe, I; Kasperk, C; Klein, R; Meeder, PJ; Nawroth, PP; Noeldge, G; Schäfer, MK; Tanner, M; Tetzlaff, R; Weiss, C; Wiedenhöfer, B, 2017) |
| "The use of morphine for treating chronic pain, however, is limited by the development of constipation, respiratory depression, tolerance and dependence." | ( Dasgupta, P; Fritzwanker, S; Günther, T; Kliewer, A; Mann, A; Miess, E; Schulz, S; Steinborn, R, 2018) |
| "Correct identification and treatment of pain in recurrent/progressive stage is crucial to prevent chronification and related changes in neural structures." | ( Coluzzi, F; Fornasari, D; Pergolizzi, J; Romualdi, P, 2017) |
| "However, undertreatment of pain in methadone patients remains a major clinical concern." | ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017) |
| "Kratom was primarily used for self-treatment of pain, mood disorders, and withdrawal symptoms associated with prescription opioid use." | ( Grundmann, O, 2017) |
| "Furthermore, undertreated pain in patients with comorbid substance use disorder poses a major clinical challenge, particularly for patients on opioid replacement therapy." | ( Morón, JA; Wilson-Poe, AR, 2018) |
| "The American Cancer Society's Treat the Pain program partners with governments in low- and middle-income countries to improve access to high-quality essential pain medicines." | ( O'Brien, M; Plattner, L; Schwartz, A, 2018) |
| "Adjuvant drugs used to treat neuropathic pain have not been studied for the treatment of adults with SCD." | ( Golembiewski, J; Molokie, RE; Schlaeger, JM; Suarez, ML; Votta-Velis, G; Wilkie, DJ; Yao, Y, 2017) |
| "The pretreatment Numeric Pain Rating Scale score of 8." | ( Cheng, AL; Lam, SKH; Reeves, KD, 2017) |
| "Nevertheless, undertreatment of pain still occurs and in many cases, staff members believed that the residents were prescribed analgesic treatment when this was not the case." | ( Gustafson, Y; Gustafsson, M; Hemmingsson, ES; Isaksson, U; Karlsson, S; Lövheim, H; Sandman, PO, 2018) |
| "Only 1 patient needed ongoing treatment by a pain medicine specialist." | ( de Jong, MB; de Steenwinkel, M; Hietbrink, F; Houwert, RM; Leenen, LPH; van Heerde, S, 2018) |
| "Adjuvant medications used to treat pain (e." | ( Farland, MZ; Horgas, AL; Marsiske, M; Snigurska, U, 2019) |
| "Opioids were no longer reserved for treatment of acute pain or terminal pain conditions but now were used to treat any pain condition." | ( Burton, MC; Dawson, NL; Rummans, TA, 2018) |
| "The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role." | ( Leppert, W; Malec-Milewska, M; Wordliczek, J; Zajaczkowska, R, 2018) |
| "The use of opioids for the treatment of pain, while largely effective, is limited by detrimental side effects including analgesic tolerance, physical dependence, and euphoria, which may lead to opioid abuse." | ( Anand, JP; Fernandez, TJ; Griggs, NW; Harland, AA; Jutkiewicz, EM; Mosberg, HI; Nastase, AF; Trask, TJ; Traynor, JR, 2018) |
| "Codeine is a first-line treatment for pain and needs to be metabolized into morphine by cytochrome 2D6 to exert its analgesic effect." | ( Bulteau, S; Caillet, P; Cazet, L; Chaslerie, A; Evin, A; Jolliet, P; Kuhn, E; Pivette, J; Spiers, A; Victorri-Vigneau, C, 2018) |
| "Preferences in opioids for the treatment of pain in nondying and dying older patients were recorded, as were the factors that were considered for these preferences." | ( Janssen, DJA; Martens, MJM; Schols, JMGA; van den Beuken-van Everdingen, MHJ, 2018) |
| "Opioids continue to be the mainstay treatment for pain at the end of life, with the prevalence of pain reported in up to 80% of patients and tends to increase as one gets closer toward the end of life." | ( Childers, J; Corbett, M; Gabbard, J; Jordan, A; Mitchell, J; White, P, 2019) |
| "This results in undertreatment of pain in those suffering from dementia." | ( Fischer, T; Hagg-Grün, U; Lukas, A; Mayer, B; Schuler, M, 2019) |
| " The treatment of pain and nipple trauma with HPA lanolin achieved better results than the one with breast milk, based on a 7-day treatment period." | ( de Albuquerque, RS; de Souza, SC; Fernandes, APS; Giesta, RO; Mariani Neto, C; Mondin, B, 2018) |
| "The aggressive treatment of pain with opioids for the last three decades has resulted in an epidemic of opioid use disorder and opioid related mortality." | ( Griggs, CA; Schulz, CJ, 2019) |
| "Un(der)diagnosed and un(der)treated pain is a serious and frequent problem in persons with dementia." | ( Achterberg, WP; Caljouw, MAA; Gussekloo, J; Husebo, BS; van Dam, PH, 2018) |
| "These data support the hypothesis that treating painful LUTS associated with pyuria with long-term antimicrobial courses, despite negative urine culture, is effective." | ( Collins, L; Dehpour, T; Dharmasena, D; Khasriya, R; Kupelian, AS; Malone-Lee, J; Rohn, JL; Swamy, S; Toteva, H, 2019) |
| "The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years." | ( Barbagallo, M; Sacerdote, P, 2019) |
| "The concurrent treatment of pain, depression or anxiety, and occupational injuries are associated with large increases in claim cost and delayed return to work." | ( Artuso, RD; Bernacki, EJ; Hunt, DL; Kalia, N; Leung, N; Tao, XG, 2019) |
| "What does this study add? Treating pain as heterogeneous explained disability better than treating pain as a single entity." | ( Ferguson, E; James, RJE; Walsh, DA, 2019) |
| "First-line medical therapies for treating pain associated with endometriosis mainly consist in combined oral contraceptives and progestins." | ( Barra, F; Ferrero, S; Scala, C, 2019) |
| "First-line treatment for the pain is opioid medications." | ( Anderson, VE; Freiermuth, CE; Gerardo, C; Kleinschmidt, KC; Lavonas, EJ; Rapp-Olsson, M; Sharma, K, 2019) |
| "The most effective treatment of pain in autoimmune and immune-mediated diseases is the treatment of the disease itself." | ( Sütő, G, 2019) |
| "Tramadol is often prescribed to treat pain and is associated physical disability in osteoarthritis (OA)." | ( Bisaillon, J; El Hindi, T; Husni, ME; Jüni, P; Maxwell, LJ; Rutjes, AW; Toupin April, K; Tugwell, P; Vincent, J; Welch, V; Wells, GA, 2019) |
| "Opioid side effects are common when treating chronic pain." | ( Castonguay, V; Chauny, JM; Cournoyer, A; Daoust, R; Lessard, J; Morris, J; Paquet, J; Piette, É; Williamson, D, 2020) |
| "Opioids are often prescribed for treating pain in patients with OA but have questionable benefit-risk profiles." | ( Blauer-Peterson, C; Gandhi, K; Johnson, J; Wei, W, 2019) |
| "Further, opioids were used to treat arthritis pain of patients with incident RA and UA less often than previously reported from other countries." | ( Kautiainen, H; Muilu, P; Puolakka, K; Rantalaiho, V; Virta, LJ, 2020) |
| "Nonetheless, concerns about undertreatment of pain in the late 20th century likely contributed to inappropriate prescribing of opioids." | ( Ashworth, JB; Gerlach, KK; Henningfield, JE; Schnoll, SH; Simone, B, 2019) |
| "The world needs 1867 tonnes ME for treating pain with opioids analgesics at an adequate level (actual use: 365 tonnes or 19." | ( Christensen, AE; Drewes, AM; Olesen, AE; Scholten, W, 2020) |
| "We have found that ginsenoside Rg3 treated the pain phases and decreased the PGE2 in formalin and carrageenan induced models, respectively." | ( Dai, CM; Fu, L; Liu, YR; Shi, SD; Sun, YQ; Wang, S; Zheng, Y, 2019) |
| "Despite the variety of treatment options, pain syndromes are widespread in the population." | ( Yakupov, EZ, 2019) |
| "The pharmacological approaches used to treat arthritic pain are often accompanied by adjuvant drugs or non-pharmacological treatments, showing a constant need in identifying new efficient analgesic drugs." | ( Anselmo-Franci, JA; Branco, LGS; Carolino, ROG; Mota, CMD; Rodrigues-Santos, C, 2020) |
| "Adequate treatment for pain in PD remains challenging, and to date, no clear guidelines for management are available." | ( Bruno, V; Farcy, N; Karnik, V; Zamorano, C, 2020) |
| "However, the treatment of TMD pain is still inadequate." | ( Crawford, J; Liu, S; Ma, Y; Shu, H; Tao, F; Xing, Y, 2020) |
| "Opioid prescriptions for treatment of pain in emergency departments (EDs) are associated with long-term opioid use." | ( Apkarian, AV; Schnitzer, TJ; Smith, BC; Vigotsky, AD, 2020) |
| "Duloxetine proved effective for treating pain in people with Parkinson's disease in a single-arm, open-label study." | ( Ando, R; Iwaki, H; Miyaue, N; Nagai, M; Nishikawa, N; Nomoto, M; Tada, S; Tsujii, T; Yabe, H; Yamanishi, Y, 2020) |
| "After a 2-week treatment, pain-related behavior was examined using von Frey filaments." | ( Kato, S; Miyamura, G; Nagao, N; Naito, Y; Sudo, A; Wakabayashi, H, 2020) |
| "Surgical treatment of pain is a logical extension of the original guideline, which is often absent in conversations with patients about treatment options for their pain and consequentially underutilized." | ( McGuire, LS; Slavin, K, 2020) |
| "Drugs used to treat pain are associated with adverse effects, increasing the search for new drugs as an alternative treatment for pain." | ( Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH, 2020) |
| "The current treatment of pain and inflammation with the available therapeutics has a number of major side effects." | ( Afroz, M; Hasan, MF; Islam, MT; Mubarak, MS; Rouf, R; Sarker, DK; Shilpi, JA; Uddin, SJ, 2021) |
| "An observer masked to the treatment assessed pain, pre- and postoperatively, with the Glasgow (GCPS), the Colorado (CPS) pain scales and a Visual Analogue Scale (VAS); additionally, the mechanical thresholds (MT) were measured with the Electronic von Frey Anaesthesiometer (EVF) at four points located near the herniated disc." | ( Adami, C; Machin, H; Taylor-Brown, F, 2020) |
| "Multimodal analgesia effectively treats pain while decreasing adverse effects." | ( George, S; Johns, M, 2020) |
| "Topical resorcinol 15% is a self-treatment for painful hidradenitis suppurativa nodules and abscesses with good results in reducing pain and lesion duration." | ( Barros-Tornay, R; Calleja-Hernández, MÁ; Cameán-Fenández, M; Cordero-Ramos, J; Delgado-Valverde, M; Merino-Bohórquez, V, 2022) |
| "Individuals treated with opioid pain relievers (OPR) develop addiction, which increases their demand for opioids and reduces their welfare and life expectancy through side effects and potential overdose." | ( Strulik, H, 2021) |
| "This study contributes to possible treatments for pain in individuals exposed to early life stress." | ( da Silva, JRT; da Silva, ML; Giusti-Paiva, A; Kalil-Cutti, B; Vieira, JS; Vilela, FC; Vitor-Vieira, F, 2021) |
| "Opioids are often used to treat pain after traumatic injury, but patient education on safe use of opioids is not standard." | ( Claridge, JA; Conrad-Schnetz, KJ; Curfman, ET; Ho, VP; Lemaitre, VC; Tseng, ES; Wise, NL; Young, BT; Zolin, SJ, 2021) |
| "sativa roots are indicated for the treatment of pain, inflammation, fever, among other health problems." | ( Araújo, TCL; Brito, MC; Lima, KSB; Lima, RS; Matos, MHT; Menezes, PMN; Monte, APOD; Neto, JA; Pereira, ECV; Ribeiro, LAA; Rolim, LA; Silva, DS; Silva, FS, 2021) |
| "There is a tendency to undertreat pain and avoid strong opioids for reasons including lack of monitoring equipment, anti-doping concerns and lack of comfort treating paediatric patients with opioids." | ( Bury, G; Doheny, MC, 2022) |
| "Ketoprofen is clinically used to treat osteoporotic pain, while long-term oral administration of ketoprofen can cause some side effects." | ( Ge, Y; Li, H; Lin, Y; Lin, Z; Tang, B; Tian, Y; Wang, K; Wang, Y; Wu, Y; Zhang, J, 2021) |
| "The guideline emphasizes treating pain in the context of each patient's overall condition and not as a separate issue." | ( Cryst, S; Ferrini, R; Hogikyan, R; Ignacio, R; Lester, PE; Levenson, S; Nalls, V; Okoroti, F; Overstreet, NK; Resnick, B, 2021) |
| "Opioids continue to be of use for the treatment of pain." | ( Majumdar, S; Streicher, JM; Varga, BR, 2023) |
| "Although dermatologists treat many painful skin conditions and perform procedures that may require analgesic use, there is a lack of evidence synthesis on opioid use in dermatology." | ( Armstrong, AW; Gutierrez, Y; Jones, ME; Kohn, AH; Pourali, SP; Rajkumar, JR, 2022) |
| "Efforts to find nonopioid regimens for treating knee OA pain should be tailored to patients at high risk for chronic use." | ( Bensen, GP; Katz, JN; Losina, E; Song, S, 2023) |
| "TRPV1 agonists are considered for the treatment of pain and inflammatory diseases." | ( Akman, M; Aliyev, E; Erin, N; Korcum, AF; Tanrıöver, G, 2022) |
| "Opioid analgesics are essential for treating cancer pain." | ( Azuma, K; Fujimiya, T; Hakamata, H; Hamada, H; Igarashi, T; Kawaguchi, T; Kojima, K; Kondo, J; Kotani, A; Mawatari, H; Miura, T; Miyasato, A; Ogura, H; Oyama, Y; Saeki, T; Tanoue, T; Tsuno, T; Yamaguchi, T; Yanaizumi, R, 2022) |
| "After treatment, the pain scores of the three groups decreased, and the scores of mobility, stability, walking ability, and the ability to walk up and down stairs increased." | ( Li, X; Liu, F; Qu, X; Sun, Z; Wang, T, 2022) |
| "The standard class of medication to treat inflammatory pain is the nonsteroidal anti-inflammatory drug (NSAID)." | ( Almeida, LD; Badenoch, B; Beatriz, A; Cristina Toffoli-Kadri, M; da Silva Gomes, R; da Silva Júnior, EN; da Silveira, IOMF; Fernandes, J; Hortelan, CRW; Janaína de Campos, L; Juliano Oliveira, R; Martins, ACF; Mohammad, J; Moslaves, ISB; Muller, JAI; Okuyama, TT, 2022) |
| "How do we treat disabling painful dystonia in PD? In this review, classification and mechanisms of pain and their management in PD especially for dystonia-related pain are described." | ( Kajiyama, Y; Mochizuki, H, 2022) |
| "After treatment, pain and adverse effects were evaluated using a modified Melbourne Pain Scale and the modified short form Glasgow Composite Measure Pain Scale (modified CMPS-SF)." | ( Baek, SJ; Hwang, CY; Kang, YH; Lee, NE; Song, SY, 2022) |
| "Approximately 20% of patients require treatment for pain and disability." | ( Currie, KB; Mackinnon, SE; Tadisina, KK, 2022) |
| "Opioids are used to treat pain, but despite their effectiveness, they possess several side effects such as respiratory depression, tolerance and physical dependence." | ( Gibula-Tarlowska, E; Karkoszka, N; Kedzierska, E; Kotlinska, J; Ziemichod, W, 2022) |
| "Ostenil Plus™ treatment improves pain, function and patient perception of functional ability in PWH and ankle arthropathy." | ( Curry, N; David, J; Mangles, S; Partington, K; Pemberton, S; Taylor, S; Wells, A, 2022) |
| "Although extensive and untreated pain that occurs during a critical developmental window may impair cognition later in life, environmental interventions early in life might promote cognition." | ( Chen, M; Chen, R; Li, X; Ling, R; Min, C; Xia, D, 2022) |
| "2hPF rates were higher for attacks treated when pain was mild vs moderate or severe: ubrogepant 50 mg (47." | ( Adams, AM; Burstein, R; Dodick, DW; Finnegan, M; Goadsby, PJ; Kuang, AW; Lai, J; Lipton, RB; Trugman, JM; Yu, SY, 2022) |
| "However, TRPV1 agonists are useful to treat pain by virtue of their ability to cause Ca 2+ influx and subsequently leading to nerve terminal desensitization." | ( Alexander, B; Baskaran, P; Bennis, J; Gustafson, N; Louis, S; Mohandass, A; Nemenov, MI; Premkumar, LS; Thyagarajan, B, 2023) |
| "It is necessary to treat neonatal pain because it may have short- and long-term adverse effects." | ( Candel-Pau, J; Fàbregas-Mitjans, M; Garcia-Garcia, J; Llufriu-Marquès, RM; López-Vílchez, MÁ; Maya-Enero, S, 2022) |
| "We extracted data on treatment duration, pain, range of motion, skin erythema, hypervascularization, edema, and X-ray findings." | ( Dumusc, A; Durand, S; Durdzińska Timóteo, A, 2022) |
| "Early treatment of pain improves outcomes after injury, while inadequate treatment leads to higher rates of post-traumatic stress disorder (PTSD)." | ( Avital, G; Bader, T; Benov, A; Chen, J; Fridrich, L; Gelikas, S; Glassberg, E; Nadler, R; Nakar, H; Sorkin, A; Tsur, AM, 2022) |
| "Rhus virens is a plant commonly used to treat diabetes or pain in the northern territory of Mexico." | ( Flores-Murrieta, FJ; Gonzalez-Cortazar, M; Herrera-Ruiz, ML; Juárez-Aragón, MC; Molina-Cabrera, J; Montiel-Ruiz, RM; Vargas-Ruiz, R; Zamilpa, A, 2023) |
| "• GNB was approved for treatment of pain in knee osteoarthritis." | ( Aly, H; Elsaman, AM; Hamed, M; Khalifa, A; Ohrndorf, S; Radwan, A, 2023) |
| "Analgesic administration treating painful, acute cellulitis at two hospitals in the Pacific Northwest included opioid and non-opioid medications." | ( Daratha, K; Fitzgerald, C; Mallo, R; Pham, S; Rangel, T; Senger, B, 2023) |
| "However, the mechanisms and treatment of pain in PD have not been well studied." | ( Chen, Y; Cheng, O; Cui, J; Li, C; Li, Y; Zhu, D, 2022) |
| "The only approved treatments for painful crises in many countries are hydroxyurea plus potent analgesics." | ( Abdelhalima, SM; Alshaeri, HK; Elberry, AA; Gamaleldin, MM; Hussein, RRS; Meabed, MH; Mohammad, BA; Murphy, JE, 2022) |
| "Consumptive coagulopathy treatment and pain management are crucial for patients with venous malformations (VMs)." | ( Chen, H; Gu, H; Hu, L; Lin, X; Liu, H; Xu, Z; Yang, X, 2023) |
| "Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc." | ( Baraldi, C; de Pinto, M; Galluzzo, C; Giuggioli, D; Guerzoni, S; Lumetti, F; Parenti, L; Salvarani, C; Spinella, A; Testoni, S, 2023) |
| "The use of opioids to treat pain can increase the risk of long-term opioid dependency and is associated with negative patient outcomes." | ( Cordero Romero, S; Floyd, SB; Garrison, S; Hendry, W; Moschella, PC; NcGarby, S; Walker, K, 2023) |
| "Although treating pain is associated with improved quality of life, most respondents did not support TA use in the ED." | ( Anderson-Quiñones, C; Asbell, P; Tolley, EA; Vestal, R; Zhu, R, 2023) |
| "Post-treatment pain was not recorded in three RBSAV and 28 analgesia-only patients." | ( Graudins, A; Sulaeman, SJ, 2023) |
| "Cannabis has been used for centuries to treat pain." | ( Li, R; Lin, G; Wang, Z; Wen, Y; Zhang, J; Zhang, R; Zhu, Y, 2023) |
| "Cannabis is marketed as a treatment for pain." | ( Barker, W; Bravata, DM; Byers, AL; Keyhani, S; Krebs, EE; Leonard, SJ; Sandbrink, F; Zaman, T, 2023) |
| "Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects." | ( Bell, J; Kachroo, P; Mossali, VM; Siddiqui, K; Zempsky, W, 2023) |
| "Undertreated pain contributes to patient suffering and lack of engagement in cancer-directed therapies." | ( Abrahm, JL; Jones, KF; Meyerson, JL; Skarf, LM, 2023) |
| "The efficacy of acupuncture in treating pain diseases has been recognized in clinical practice, and its mechanism of action has been a hot topic in academic acupuncture research." | ( Cao, WY; He, W; Jing, XH; Qu, ZY; Shi, JT; Su, YS; Wan, HY; Wang, R; Wang, XY; Zhang, XN, 2023) |
| "A significant interaction effect of treatment (painful, non-painful) and outcome (win, loss) was observed on delta oscillation as pain only enhanced the power of win feedback." | ( Li, X; Wang, C; Zheng, H; Zhou, X, 2023) |
| "After the treatment, his pain almost completely disappeared." | ( Chang, MC; Lee, GW; Park, WT, 2023) |
| "Data included cancer diagnosis and treatments, pain severity, prescription opioid characteristics, demographics, and other clinical factors." | ( Chandra, R; Clayburgh, D; Handley, R; Hooker, ER; Knight, SJ; Morasco, BJ; Nugent, SM; Slatore, CG; Winchell, K, 2023) |
| "This may lead to chronicity of the untreated pain contributors as well as causing adverse consequences on quality of life and psychological health." | ( Caprara, F; Cetera, GE; Facchin, F; Merli, CEM; Pesce, E; Vercellini, P; Viganò, P, 2023) |
| "The pre-treatment pain severity of the groups was similar (p = 0." | ( Ak, R; Aykanat, MC; Cimilli Öztürk, T; Kılıç, M; Ustaalioğlu, İ, 2023) |
| "The minimal treatment-related pain and high patient satisfaction makes it a promising treatment for patients with needle-phobia and/or severe pain during needle injections." | ( Bik, L; Elmzoon, I; Prens, EP; van Doorn, MBA; Wolkerstorfer, A, 2023) |
| "Ferric carboxymaltose treatment reduces pain levels and improves the quality of life in women with fibromyalgia." | ( Aydemir, AE; Gürcü, S; Hamarat, H; Kıvanç, BK, 2023) |