| "Immediate relief of pain is experienced after the solution of local anaesthetic and steroid has been deposited deep within the fleshy portion of the muscle." | ( Wyant, GM, 1979) |
| "Pain is not an electrical impulse derived from tissue injury but an emotional experience arising when a nervous input is interpreted in the light of experience and emotional context as being 'painful'." | ( Marsden, CD, 1979) |
| "This pain is aggravated by exercise, walking downstairs and sharp bending of the knee." | ( Weiser, HI, 1979) |
| "The pain is elicited by exertional ischaemia." | ( Orava, S; Puranen, J, 1979) |
| "Full sedation of pain is achieved in 30 to 40 p." | ( Farcot, JM; Farny, J; Gauthier-Lafaye, P; Haberer, JP; Laugner, B; Schoeffler, P, 1979) |
| "Thus, pain is a non-osmolar factor capable of elevating AVP in conscious man." | ( Fisher, DA; Kendler, KS; Weitzman, RE, 1978) |
| "Pain is defined as the central perception of senses evoked by peripheral sensors." | ( Grabow, L, 1978) |
| "When the ureteral pain is due to hyperperistalsis the drug has promise in the alleviation of pain." | ( Boyarsky, S; Labay, PC, 1978) |
| "Usually such pains are observed in patients with 2 and more cornary arteries affected by the disease." | ( Buslenko, NS; Fitileva, LM; Zingerman, LS, 1975) |
| "Growing pains is a poorly named, nebulous entity that can be diagnosed only by exclusion." | ( Peterson, HA, 1977) |
| "Growing pains are recurrent limb pains peculiar to children." | ( Calabro, JJ; Holgerson, WB; Repice, MM; Wachtel, AE, 1976) |
| "Pain is a common and feared symptom for patients with incurable cancer." | ( Brescia, FJ; Gray, G; Krasnoff, L; Portenoy, RK; Ryan, M, 1992) |
| "Neuropeptides and pain is discussed in relation to tachykinins and their antagonists, cholecystokinin (CCK) and its antagonists and somatostatin." | ( Duggan, AW, 1992) |
| "Pain is the most frequently reported symptom in the health care industry today." | ( Kodiath, A; Kodiath, MF, 1992) |
| "The origin of the pain is uncertain, although mechanisms related to optic nerve or ocular muscle involvement should be considered." | ( de Stoutz, N; Mermoud, A; Safran, AB, 1992) |
| "Shoulder pain is a common problem in hemiplegia." | ( Joynt, RL, 1992) |
| "Some pains are morphine resistant, especially those due to nerve injury." | ( Twycross, RG; Zylicz, Z, 1991) |
| "Acute pain is easy to diagnose, the cause of pain obvious and the treatment logical, chronic pain has a greater psychological component, is difficult to diagnose and treatment is often empirical." | ( Boey, WK, 1991) |
| "The pain is most frequently the characteristic symptom of osteoarthritis of the wrist, however it may appear without an accident (as a part of destructive and systemic disease, damaging the joints) too." | ( Kubatov, M; Renner, A; Viola, T; Zimmermann, I, 1991) |
| "Anterior knee pain is a frequent musculoskeletal complaint affecting all ages, both sexes, athletes, and nonathletes alike." | ( Beaman, DN; Glover, RA; Janda, D; Wojtys, EM, 1990) |
| "Neurogenic pain is defined as pain due to dysfunction of the peripheral or central nervous system, in the absence of nociceptor (nerve terminal) stimulation by trauma or disease." | ( Bowsher, D, 1991) |
| "In addition, when pain is identified, physicians may be apprehensive about the use of strong analgesic drugs and their side effects, so that pain control is poor." | ( Hillier, R, 1990) |
| "Pain is an understudied problem in geriatric medicine and especially among nursing home residents." | ( Ferrell, BA; Ferrell, BR; Osterweil, D, 1990) |
| "Bone pain is the commonest type of pain in cancer patients." | ( Hanks, GW, 1988) |
| "Pain is an important symptom in many of these patients, but it is often either unrelieved or poorly controlled." | ( Coates, G, 1985) |
| "Pain is one of the most feared consequences of cancer." | ( Foley, KM, 1985) |
| "Pain is a frequent problem following recent traumatic spinal cord injury (SCI)." | ( Cremer, SA; Davidoff, G; Maynard, F, 1989) |
| "Deafferentation pain is known usually to be resistant to both narcotic and non-narcotic analgesics." | ( Ghose, K, 1989) |
| "Pain is a sensory and emotional experience and, as such, is always subjective." | ( Helme, RD, 1987) |
| "Pain is probably the only sensation that can be evoked by stimulation of dentin or dental pulp in man." | ( Matthews, B, 1985) |
| "Pain is not solely a fixed neurophysiologic response to a noxious stimulus but a product of the interaction of many variables such as age, cognitive set, personality, ethnic background, and emotional state." | ( Schechter, NL, 1985) |
| "Chronic pain is refractory to most currently marketed regimens." | ( Gershon, S, 1986) |
| "The pain is blocked and its memory erased so that continued, uninterrupted relief is given." | ( Driscoll, CE, 1987) |
| "Pain is a complex somato-psychic experience, and all pains do not respond equally to opioid analgesics." | ( Twycross, RG, 1988) |
| "Chronic pain is a common feature of well-established MS and is usually associated with a myelopathy." | ( Ebers, GC; Foley, KM; Moulin, DE, 1988) |
| "Pain is commonly the initial symptom in peptic ulcer, but the mechanism is controversial." | ( Texter, EC, 1987) |
| "The subject of pain is intimately related to that of mandibular function." | ( Davidson, RM; Mohl, ND, 1987) |
| "Pain is felt in the muscles and joint ligaments whose biological tolerance has been exceeded; this tolerance varies individually and must be genetically determined." | ( Fry, HJ, 1986) |
| "Growing pain is a poorly named, nebulous entity that can be diagnosed only by exclusion." | ( Peterson, H, 1986) |
| "Pain is the most common initial symptom, present in 57 per cent of the cases, followed by sensory disturbances and motor involvement." | ( Arce, CA; Dohrmann, GJ, 1985) |
| "Drug treatment of pain is largely based on clinical experience." | ( Adriaensen, H; van de Walle, J; Vanmeenen, H, 1981) |
| "Pain is the most relevant symptom for many cancer patients, therefore treatment is of great importance." | ( Zimmermann, M, 1982) |
| "Pain is a phenomenon experienced by all forms of life." | ( Nickles, SL; Pressman, AH, 1984) |
| "Chronic pain is recognized to be the most frequent cause of disability in the United States and many industrialized nations today, and is a major cost to society in both work hours lost and medical expenses." | ( Chapman, CR, 1984) |
| "However, chronic pain is poorly understood and, by definition, poorly managed." | ( Fields, HL; Levine, JD, 1984) |
| "Usually, pain is caused by the excitation of nociceptors or of nociceptive afferent fibers." | ( Zimmermann, M, 1981) |
| "Fever and pain are the most common issues in pediatric patient management." | ( Gladtke, E, 1983) |
| "Pain is traditionally measured in analgesic studies by employing verbal descriptors of intensity, but more recently visual analogues of pain intensity have been used and generally provide more sensitive measures of pain intensity." | ( Wallenstein, SL, 1984) |
| "Chronic pain is distinguished from persistent pain and it is proposed that chronic pain involves addiction to the endogenous opioid system." | ( Portnow, JM, 1984) |
| "Chest pain is thus a common problem of adolescence that produces considerable functional impairment not attributable to serious underlying disease." | ( Goodman, BW; Pantell, RH, 1984) |
| "Since pain is a complex psychophysical phenomenon, algesimetry has a lot of inherent problems which are discussed." | ( Handwerker, HO, 1984) |
| "Pain is also the most important of the 3 health status components in explaining medication usage (P less than 0." | ( Anderson, JJ; Kazis, LE; Meenan, RF, 1983) |
| "Disabling shoulder pain is common in those who engage in athletic activities and there is a wide spectrum of causes." | ( Leach, RE; Schepsis, AA, 1983) |
| "When pain is localized to joints, the patient must be carefully evaluated." | ( Weiner, SR, 1983) |
| "Spontaneous pain is also relieved." | ( Loch, MH; Loch, WE; Reiriz, HM; Wenger, AP, 1983) |
| "Calf pain is a common complaint in the primary care setting." | ( Katerndahl, DA, 1980) |
| "If pain is in the trigeminal nerve distribution, local nerve block procedures may provide additional relief." | ( McCann, CF; Scott, RM; Shapshay, SM; Stoelting, I, 1980) |
| "Learned pain is a distinct entity with its own set of symptoms, diagnostic criteria, and treatment methods." | ( Brena, SF; Chapman, SL, 1981) |
| "Pain is a sensory end-point that can be generated by a number of dissimilar processes." | ( Woolf, CJ, 1994) |
| "Visceral pain is an important component of many clinical pain states." | ( Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K, 1995) |
| "Pain is a well known complication of propofol injection." | ( Khoo, ST; Tham, CS, 1995) |
| "The pain is caused mainly by the vehicle." | ( Frenken, LA; Koene, RA; van Lier, HJ, 1994) |
| "Pain is not usually considered a symptom of chronic relapsing demyelinating polyneuropathy." | ( Brunet, DG; Zochodne, DW, 1994) |
| "Pain is among the most prevalent symptoms experienced by cancer patients." | ( Cherny, NI; Portenoy, RK, 1993) |
| "Pain is one of the most common and feared symptoms associated with cancer." | ( Grossman, SA; Staats, PS, 1994) |
| "Chronic central pain is a frequent complication after spinal cord injury." | ( Andreasen, A; Drewes, AM; Poulsen, LH, 1994) |
| "Cancer pain is prevalent and undertreated despite the availability of therapeutic options that, taken together are highly effective, economical and safe." | ( Patt, RB, 1994) |
| "Tourniquet cuff pain is a significant cause of morbidity following regional anaesthesia of the upper limb." | ( Fell, RH; James, NK; Khoo, CT, 1994) |
| "Pain is an important problem for patients with cancer and is particularly important for elderly patients with cancer and their family care givers." | ( Ahn, C; Ferrell, BA; Ferrell, BR; Tran, K, 1994) |
| "Procedure-related pain is a significant problem for many children receiving cytotoxic chemotherapy." | ( Arnold, M; Betcher, DL; Dose, AM; Goh, TS; Loprinzi, CL; MacKellar, DJ; Miser, AW; Niedringhaus, RD; O'Fallon, JR; Simmons, P, 1994) |
| "When pain is manifested, it appears late during the ischemic event." | ( Sylvén, C, 1993) |
| "Pain is a common and complex problem in the geriatric population." | ( Forman, WB; Roche, RJ, 1994) |
| "Since pain is induced proximal to the peripheral nociceptors, the model can be used to test central analgesic properties of i." | ( Björkman, R; Elam, M, 1993) |
| "Dental pain is usually the first sign and can induce misdiagnosis." | ( Eury, J; Gilain, L; Peynegre, R, 1993) |
| "Why anorectal pain is relieved by sitting in a warm-water bath was investigated in 18 healthy volunteers and 28 patients with painful anorectal disease (18 patients with fissures and 10 with hemorrhoids)." | ( Shafik, A, 1993) |
| "Pain is the symptom that patients want addressed." | ( Schnitzer, TJ, 1993) |
| "Incident pain is a major problem for most patients with cancer pain." | ( Jadad, AR; McQuay, HJ, 1994) |
| "Procedural pain is more common than pain related to disease in the management of paediatric cancer." | ( Cavalletto, B; Cooper, MG; Dalla Pozza, L; Kilham, HA; Stevens, MM, 1994) |
| "Pain is difficult and sometimes frustrating to treat, even though new devices and new approaches have been developed in recent years." | ( Labrecque, G; Vanier, MC, 1995) |
| "Although periobital pain is a frequent finding in patients suffering from cluster headaches, to the authors' knowledge this is the first reported case of orbital inflammation with cluster headache." | ( Acquadro, MA; Chen, VN; Rubin, PA, 1996) |
| "Pain is an important symptom in 75 to 80% of noncancer patients in the last year of life." | ( Burt, R; Butler, RN; Foley, KM; Morris, J; Morrison, RS, 1996) |
| "Leg and/or back pain is associated with the intrathecal use of hyperbaric 5% lignocaine." | ( Aromaa, U; Cozanitis, DA; Salmela, L, 1996) |
| "Pain is an important indicator of stress particularly after surgical operation." | ( Cherng, CH; Ho, ST; Wong, CS, 1995) |
| "Pain is a significant health problem, and there is considerable need for clinical and epidemiological research in this topic." | ( Ejlersen, E; Hamburger, H; Hansen, I; Sabroe, S; Sørensen, HT, 1996) |
| "Long-term pain is a common sequela of thoracotomy, occurring in approximately 50% of patients 2 years after thoracic surgery." | ( Jackson, M; Katz, J; Kavanagh, BP; Sandler, AN, 1996) |
| "If chymopapain is used as a first-line treatment, with surgery reserved for the failures, the long-term outcome is good or excellent in 82%." | ( Bradbury, N; Mulholland, RC; Wilson, LF, 1996) |
| "Pain is common among children infected with HIV and can adversely impact on their lives, and its management should be a component of the general care of these patients." | ( Dragisic, K; Hirschfeld, S; Moss, H; Pizzo, PA; Smith, W, 1996) |
| "When pain is the primary indication, the use of adjuvant analgesics is one strategy that must be evaluated in comparison with other potentially analgesic approaches." | ( Portenoy, RK, 1996) |
| "Chronic pain is a significant public health problem and frustrating for everyone affected by it." | ( Clark, MR; Koenig, TW, 1996) |
| "Pain is normally evoked only by stimuli that are sufficiently intense to activate high-threshold A(delta) and C sensory fibres, which relay the signal to the spinal cord." | ( Doubell, TP; Leslie, T; Neumann, S; Woolf, CJ, 1996) |
| "Moderate to severe pain is a common and early symptom of GBS and requires aggressive treatment." | ( Amireh, R; Feasby, TE; Hagen, N; Hahn, A; Moulin, DE, 1997) |
| "The pain is conventionally controllable with moderate to relatively high doses of intravenous morphine." | ( Slart, R; Sorkin, LS; Yaksh, TL; Yu, AL, 1997) |
| "Neuropathic pain is the most common form of opioid-poorly-responsive pain." | ( Forbes, K; Hanks, GW, 1997) |
| "Many pains are controlled by non-addictive procedures ranging from exercise to a variety of analgesic medications." | ( Merskey, H, 1997) |
| "The pain is relieved by sitting or lying down, not by standing and resting as would be seen in arterial insufficiency-induced claudication." | ( Christensen, VM; Funk, JD; Goldman, SM, 1997) |
| "Pain is a well known complication of propofol injection." | ( Bornscheuer, A; Goldmann, R; Kirchner, E, 1997) |
| "Pain is the main reason prompting patients to consult their physicians." | ( Brasseur, L, 1997) |
| "Pain is the major symptom that leads patients to consult their physicians for the treatment of arthritis; therefore, effective pain control is an important goal in the management of this disorder." | ( Lane, NE, 1997) |
| "Because pain is a biopsychosocial phenomenon, psychological and social assessment are essential along with adequate trials of opioid responsiveness." | ( Krames, ES; Olson, K, 1997) |
| "Pain is the most feared symptom for patients diagnosed with cancer." | ( Ahmedzai, S, 1997) |
| "Pain is the most frequent symptom." | ( De Laat, M; Devulder, J; Dumoulin, K; Ghys, L; Rolly, G, 1997) |
| "Physical pain is a major trigger for changes in many homeostatic systems of the body physiology." | ( Andersson, HI; Kandell-Collén, A; Nilsson, PM, 1997) |
| "Pain is a frequent and distressing complaint in patients with multiple sclerosis (MS) and may present a difficult therapeutic problem." | ( Houtchens, MK; Richert, JR; Rose, JW; Sami, A, 1997) |
| "Breast pain is a common, often distressing problem among women." | ( Rodriguez, JL; Steinbrunn, BS; Zera, RT, 1997) |
| "Although pain is the most feared part of the terminal life of many patients with cancer, the intensity and the quality of the pain is all too often only scantly described." | ( Andrén-Sandberg, A; Grahm, AL, 1997) |
| "Breakthrough pain is usually treated with short-acting oral opioids, most of which provide some relief after 15-20 minutes, with peak effects after 30-45 minutes." | ( Busch, M; Cleary, J; Farrar, JT; Nordbrock, E; Rauck, R, 1998) |
| "Subcalcaneal pain is a common complaint presented to the orthopaedist." | ( Geppert, MJ; Mizel, MS, 1998) |
| "The cause of the pains is uncertain but similar symptoms have been reported in subjects with benign intracranial hypertension and may relate to spinal nerve root pouch distension." | ( Gallagher, AC; Trounce, JQ, 1998) |
| "Daily pain is prevalent among nursing home residents with cancer and is often untreated, particularly among older and minority patients." | ( Bernabei, R; Dunlop, R; Gambassi, G; Gatsonis, C; Landi, F; Lapane, K; Lipsitz, L; Mor, V; Steel, K, 1998) |
| "Malignancy-related pain is of similar frequency in children and adolescents as in adults." | ( Döbig, C; Griessnger, N; Likar, R; Sittl, R; Winter, E, 1998) |
| "Pain is a common feature of interstitial cystitis (IC)." | ( Buffington, CA; Wolfe, SA, 1998) |
| ""Breakthrough pain" is a common clinical term that has not been conclusively defined or described." | ( Ellison, NM; Patt, RB, 1998) |
| "Pain is frequent in the course of cancer and can have negative consequences on patients quality of life." | ( Delfosse, MH; Latour, JF; Ranchere, JY; Saltel, P, 1998) |
| "Overall, pain is one of the most common symptoms associated with cancer and often produces greater anticipatory distress than other features of the disease." | ( Roth, SL; Strumpf, M; Zenz, M, 1998) |
| "Thus, pain is exacerbated by measures inhibiting the immigration of opioid-producing cells or, conversely, analgesia might be conveyed by adhesive interactions that recruit those cells to injured tissue." | ( Cabot, PJ; Machelska, H; Mousa, SA; Stein, C; Zhang, Q, 1998) |
| "Pain is the most disturbing symptom of diabetic peripheral neuropathy." | ( Backonja, M; Beydoun, A; Edwards, KR; Fonseca, V; Garofalo, E; Hes, M; LaMoreaux, L; Schwartz, SL, 1998) |
| "Burn-wound pain is severe, inconsistent and underestimated." | ( Joubert, K, 1998) |
| "Growing pains is an accepted medical term, though the pains are not due to growing." | ( Manners, P, 1999) |
| "Chronic pain is an important cause of suffering, disability and loss of productivity within the community." | ( Chambers, WA; Penny, KI; Purves, AM; Smith, BH; Smith, WC, 1999) |
| "Pain is the most common complaint of patients who see rheumatologists." | ( Moreland, LW; St Clair, EW, 1999) |
| "In a minority the pains are debilitating and there is stiffness in movement." | ( Angastiniotis, M; Aristidou, K; Eracleous, E; Kanakas, A; Pavlides, N; Posporis, T; Yerakaris, M, 1998) |
| "The pain is typically felt deeply and diffusely, has an orthostatic component, and is suppressed by the ischemia test." | ( Blumberg, H; Hoffmann, U; Mohadjer, M; Scheremet, R, 1997) |
| "Pain is one of the most common reasons for patients to seek medical care." | ( Longton, WC; Mazonson, PD; Zagari, MJ, 1996) |
| "Pain is the most common symptom of advanced cancer." | ( Levy, MH, 1999) |
| "Severe pain is common." | ( Ferrucci, L; Fried, LP; Guralnik, JM; Ling, S; Lyles, A; Pahor, M; Penninx, BW; Wan, JY, 1999) |
| "The BK-induced pain is abolished or reduced by acetylsalicylate, thus suggesting that acetylsalicylate-sensitive mediators, such as prostaglandins, are involved in its pathogenesis." | ( Chiariello, L; Crea, F; Gaspardone, A; Gioffré, PA; Pellegrino, A; Tomai, F; Versaci, F, 1999) |
| ""Pain is an incredibly complicated pathophysiologic process, as well as a highly individualized experience," says Dr." | ( Zarbock, SF, 1999) |
| "Pain is unique among sensations in that the perceived intensity increases, or sensitizes, during exposure to a strong stimulus." | ( Cesare, P; Dekker, LV; McNaughton, PA; Parker, PJ; Sardini, A, 1999) |
| "Pain is a key issue with these users; however, they are probably not receiving optimal treatment." | ( Busto, UE; Romach, MK; Sellers, EM; Somer, G; Sproule, BA, 1999) |
| "Chronic pain is disabling, and the adverse effects of morphine are also disabling." | ( Cain, CK; Francis, JM; Lindner, MD; Plone, MA, 1999) |
| "Pain is a multidimensional experience." | ( Pourchet, S; Salamagne, MH, 1999) |
| "Breakthrough pain is defined as the transient exacerbation of pain occurring in a patient with otherwise stable, persistent pain." | ( Simmonds, MA, 1999) |
| "Chronic pain is recognised as an important problem in the community but our understanding of the epidemiology of chronic pain remains limited." | ( Chambers, WA; Elliott, AM; Penny, KI; Smith, BH; Smith, WC, 1999) |
| "Chronic pain is a major problem in the community and certain groups within the population are more likely to have chronic pain." | ( Chambers, WA; Elliott, AM; Penny, KI; Smith, BH; Smith, WC, 1999) |
| "The neuropathic pain is specific to inflammation of the nerve because it was absent in animals with the experimental myositis and in those receiving sham-treatment." | ( Bennett, GJ; Eliav, E; Herzberg, U; Ruda, MA, 1999) |
| "When pain is relieved inadequately by opioid analgesics given in a dose that causes intolerable side effects despite routine measures to control them, treatment with the same opioid by an alternative route or with an alternative opioid administered by the same route should be considered." | ( Mercadante, S, 1999) |
| "Persistent pain is the most debilitating sequela and it occurs in at least 15% of individuals over 50 years of age." | ( Gnann, JW; Whitley, RJ, 1999) |
| "Knee and leg pain are the most common symptoms, and physicians working in orthopaedics and traumatology are the first to be consulted." | ( Katthagen, BD; Sistermann, R, 2000) |
| "Significant pain is common but is often undertreated despite available medications and technology." | ( Clasen, ME; Jonas, AP; Whitecar, PS, 2000) |
| "Neuropathic pain is often associated with the appearance of pain in regions not related to the injured nerve." | ( Bian, D; Gardell, LR; Ibrahim, M; Lai, J; Malan, TP; Ossipov, MH; Porreca, F, 2000) |
| "Bone cancer pain is common among cancer patients and can have a devastating effect on their quality of life." | ( Clohisy, DR; Honore, P; Luger, NM; Mach, DB; Mantyh, PW; O'keefe, PF; Ramnaraine, ML; Rogers, SD; Sabino, MA; Schwei, MJ, 2000) |
| "Pain is a ubiquitous component of pediatric illness and injury." | ( Schechter, NL; Zempsky, WT, 2000) |
| "Pain is a disruptive influence on infants in the NICU." | ( Franck, LS; Gibbins, S; Stevens, B, 2000) |
| "Generally, pain is not well controlled in hospitals and steps need to be taken to make pain control more effective." | ( Ravenscroft, P; Schneider, J, 2000) |
| "Neuropathic pain is associated with abnormal tactile and thermal responses that may be extraterritorial to the injured nerve." | ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F, 2000) |
| "Pain is an important symptom of acute damage and chronic inflammatory diseases such as rheumatoid arthritis." | ( Schaible, HG; Vanegas, H, 2000) |
| "Pain is the primary problem targeted for control using the World Health Organization's (WHO) analgesic ladder." | ( Hamann, SR; McDonnell, FJ; Sloan, JW, 2000) |
| "Pain is a subjective phenomenon that we can measure only by indirect methods." | ( Okifuji, A; Turk, DC, 2000) |
| "Neuropathic pain is increased, and the mice show a complete absence of the pharmacological analgesic effects of NPY." | ( Blakeman, KH; Ernfors, P; Hao, JX; Hassani, H; Lucas, G; Naveilhan, P; Thorén, P; Wiesenfeld-Hallin, Z; Xu, XJ, 2001) |
| "Pain is prevalent and undertreated in nursing home residents, despite the existing wide array of effective pharmacological and nonpharmacological treatment modalities." | ( Hanlon, JT; Weiner, DK, 2001) |
| "Perineal pain is one of the most common causes of maternal morbidity in the early puerperium." | ( Alfirevic, Z; Corkill, A; Lavender, T; Walkinshaw, SA, 2001) |
| "Pain is often inadequately treated, although it can be controlled simply in the majority of cases." | ( Bertolaccini, L; Olivero, G, 2000) |
| "Pain is the primary problem targeted for control using the World Health Organization's (WHO) analgesic ladder." | ( Hamann, SR; McDonnell, FJ; Sloan, JW, 2001) |
| "Osteoarthritis pain is of multifactorial origin, and inflammatory mechanisms play only a partial role." | ( Pavelka, K, 2000) |
| "Pain is a significant problem in many patients with genitourinary malignancy at all stages of disease." | ( Harrison, P, 2001) |
| "Pain is a comprehensive phenomenon which concerns not only physiology, biochemistry and molecular biology but also music, art, religion, philosophy and everyday life." | ( Währborg, P, 2001) |
| "(Breakthrough pain is a transient increase in pain in a patient who has stable, persistent pain treated with opioids." | ( de Wit, R; Enting, RH; Lieverse, PJ; Smitt, PA; van der Rijt, CC; Wilms, EB, 2001) |
| "Although knee pain is the impetus for imaging, ganglion cysts are often incidental findings." | ( Ellen, MI; Gilhool, JJ; Rogers, DP, 2001) |
| "Joint pain is a very common complaint among elderly persons and may lead to functional disability." | ( Al Snih, S; Goodwin, JS; Markides, KS; Ray, L, 2001) |
| "Pinprick pain is mediated primarily by capsaicin-insensitive A-fibre nociceptors, which include high-threshold mechanoreceptors and type I mechano-heat nociceptors." | ( Fuchs, PN; Magerl, W; Meyer, RA; Treede, RD, 2001) |
| "Chronic pain is a widespread, difficult problem facing clinicians." | ( Adams, NJ; Fleming, MF; Mundt, MP; Plane, MB; Saunders, LA; Stauffacher, EA, 2001) |
| "Management of pain is a great problem in patients with cancer." | ( Kuraishi, Y, 2001) |
| "Undertreatment of pain is a persistent clinical problem for patients with cancer." | ( Dohi, S, 2001) |
| "When the cancer pain is classified as neuropathic pain, we should use antidepressants, anticonvulsants, anxiolytics, or/and anti-arrhythmic drug." | ( Morimoto, M, 2001) |
| "Disabling chronic pain is especially devastating among working population and, in many cases, it does not respond to conventional therapies." | ( Arias i Gassol, A; Cerdà Gabaroi, D; Collado Cruz, A; Muñoz-Gómez, J; Torres i Mata, X; Valdés Miyar, M; Vilarrasa, R, 2001) |
| "Pain is the most prominent symptom and clinical finding in osteoarthritis (OA)." | ( Lipman, AG, 2001) |
| "Pain is a significant problem for community-dwelling elders and for elderly persons in residential facilities." | ( Miaskowski, C, 2000) |
| "Pain is a complex phenomenon with a strong affective-emotional component in addition to a sensory-discriminative one." | ( Cruccu, G; Di Legge, S; Di Piero, V; Ferracuti, S; Lenzi, GL; Pantano, P; Sabatini, U; Tombari, D, 2001) |
| "The pain is characterized by a burning or stinging sensation similar to neuropathic pain sensations." | ( Andersen, J; Ehrnrooth, E; Grau, C; Zachariae, R, 2001) |
| "Neuropathic pain is a debilitating chronic syndrome that often arises from injuries to peripheral nerves." | ( Bian, D; Gold, MS; Hunter, JC; Kim, CS; Lai, J; Ossipov, MH; Porreca, F, 2002) |
| "Pain is defined as an unpleasant experience-it is subjective and achieving pain relief is achieving a change in the patient's experience." | ( Lickiss, JN, 2001) |
| "Pain is undertreated in all parts of the world." | ( Heit, HA, 2001) |
| "The 'patient' with pain is a complex individual and the 'drug' is not the same in effect to every patient, regardless of being an opioid analgesic." | ( Mather, LE, 2001) |
| "The management of pain is still a critical issue in the care of patients both with cancer and non-cancer pain." | ( Huang, Y, 2001) |
| "Chronic non-cancer pain is a complex biopsychosocial phenomenon; as such it is unlikely that any one treatment modality will achieve relief." | ( Goucke, CR, 2001) |
| "The assessment of pain is difficult and should include both physiological and behavioural parameters." | ( Schollin, J, 2001) |
| "Intraoperative pain is the main topic that requires improvement." | ( Bech, K; Callesen, T; Kehlet, H, 2001) |
| "Pain is common but is often undertreated in critically ill patients." | ( McCaffery, M; Pasero, C, 2001) |
| "Since pain is an important symptom in arthritis, useful behavioral indices for pain in experimental arthritis animal models are important tools for investigative work on arthritis." | ( Chung, JM; Grady, JJ; Kim, CH; Koo, ST; Lyu, Y; Yu, YC, 2002) |
| "Pain is a feature of many cancers, particularly in the advanced stages at which the palliative care approach to symptom control achieves the best outcomes." | ( Gourlay, GK, 2001) |
| "Pain is an unpleasant sensory and emotional experience usually triggered by stimulation of peripheral nerves and often associated with actual or potential tissue damage." | ( Clare, S; Gati, JS; Matthews, PM; Menon, RS; Ploghaus, A; Smith, S; Tracey, I, 2002) |
| "Although continuous pain is by far less severe than intermittent pain, the treatment is, in both cases, essentially pharmacological relying basically on opioids." | ( Latarjet, J, 2002) |
| "Anticipation of pain is a complex state that may influence the perception of subsequent noxious stimuli." | ( Baraldi, P; Facchin, P; Maieron, M; Nichelli, P; Pagnoni, G; Porro, CA; Serafini, M, 2002) |
| "Pain is often reported as a symptom of CI and it is defined as a subjective experience similar to many other symptoms of CI, making its objectification difficult." | ( Bushnell, MC; Duncan, GH; Rainville, P, 2001) |
| "Cancer pain is a significant problem despite the advent of the World Health Organization's cancer pain guidelines, the US government's cancer pain guidelines, and the Joint Commission's mandate for hospital pain evaluation and treatment." | ( Lordon, SP, 2002) |
| "Pain is a common feature of spasticity and muscle spasms and the reasons for this are discussed in this article." | ( Kadies, M; Ward, AB, 2002) |
| "Loin pain is precipitated in the case of the former and urinary retention in the latter case after consuming alcohol." | ( Arun, CP, 2002) |
| "Fear of block pain is diminished after experiencing the blocking procedure." | ( Koscielniak-Nielsen, ZJ; Rassmussen, H; Rotbøll-Nielsen, P, 2002) |
| "Pain is the major complaint of patients who choose acupuncture treatment." | ( Attele, AS; Dey, L; Guan, X; Lynch, JP; Yuan, CS, 2002) |
| "Pain is very common throughout the world and is an increasing problem in the ageing population." | ( Moore, RA, 2002) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | ( , 2002) |
| "capsaicin-induced pain is acceptable for pharmacological profiling of novel anti-nociceptive agents, with limited number of subjects." | ( Growcott, J; Hughes, A; Macleod, A; Thomas, I, 2002) |
| "Pain is the most feared symptom for patients with advanced cancer." | ( Regaard, A, 2000) |
| "This pain is of short duration and after 3 minutes, the level of pain is independent of the type of device which has been inserted." | ( Goldstuck, ND, 1981) |
| "Pain is associated with myriad medical conditions and affects millions of Americans." | ( Argoff, CE, 2002) |
| "Pain is unnecessary." | ( Li, JM, 2002) |
| "Pain is the cancer related event that is most disruptive to the cancer patient's quality of life." | ( Clohisy, DR; Honore, P; Keyser, CP; Luger, NM; Mach, DB; Mantyh, PW; Pomonis, JD; Rathbun, M; Sabino, MAC; Schwei, MJ; Yaksh, TL, 2002) |
| "Burn-induced pain is often inadequately managed and its mechanisms, both peripheral and central, are poorly understood." | ( Junger, H; Moore, AC; Sorkin, LS, 2002) |
| "Pain is a multi-dimensional process involving the physical, emotional and perceptual integration of noxious information." | ( Blackburn-Munro, G; Blackburn-Munro, R, 2003) |
| "Indeed, chronic pain is often inadequately controlled in patients with cancer and in those with non-cancer chronic pain." | ( Nicholson, B, 2003) |
| "Chronic noncancer pain is common in Canadian adults and has a major social and economic impact." | ( Clark, AJ; Morley-Forster, PK; Moulin, DE; Speechley, M, 2002) |
| "Bone cancer pain is very common, and patients with this type of pain may be difficult to treat." | ( Clohisy, DR; Mantyh, PW, 2003) |
| "Delirium and pain are common following hip fracture." | ( Gilbert, M; Koval, KJ; Magaziner, J; McLaughlin, MA; Morrison, RS; Orosz, G; Siu, AL; Strauss, E, 2003) |
| "Short-lasting pain is induced by gaseous CO(2), while long-lasting pain is induced by a stream of dry air." | ( Hummel, T; Kobal, G; Lötsch, J; Marchl, R; Mohammadian, P, 2003) |
| "Pain is associated with negative affect such as anxiety and depression." | ( Li, W; Neugebauer, V, 2003) |
| "Treating this pain is often difficult, particularly in elderly patients, owing to iatrogenic effects and to interactions with the pre-existing diseases and treatments frequently present in this age group." | ( Chiquet, C; Gain, P; Maugery, J; Michaud, P; Navez, ML; Pascal, J; Thuret, G, 2003) |
| "Bone pain is a common side effect of treatment with filgrastim." | ( Glaspy, J; Green, MD; Hackett, J; Holmes, FA; Kubista, E; Neumann, T, 2003) |
| "Pain is one of the most common reasons for seeking medical attention, and neuropathic pain is among the most common types of pain." | ( Backonja, M; Glanzman, RL, 2003) |
| "Chronic pain is a common problem affecting about half of the general population." | ( Chambers, WA; Elliott, AM; Haetzman, M; Hannaford, P; Smith, BH, 2003) |
| "Chronic severe pain is prevalent among patients in substance abuse treatment, especially MMTP patients." | ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003) |
| "Control of chronic pain is a major health problem." | ( Cheng, JT; Lee, CT; Lin, CR; Lin, MW; Tai, MH; Tan, PH; Yang, LC; You, HL, 2003) |
| "The sense of pain is an important defense mechanism that has evolved in many species, including ours." | ( Stulhofer, M, 2002) |
| "Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain." | ( Aşik, I; Gülay, I; Tulunay, M; Yörükoğlu, D, 2003) |
| "Neuropathic pain is a significant clinical problem." | ( Abdi, S; Borsook, D; DiLorenzo, L; Feroz, N; Kobierski, LA, 2003) |
| "Pain is more than a sensation; it is influenced by emotional, cognitive, and psychosocial factors." | ( Leo, RJ; Pristach, CA; Streltzer, J, 2003) |
| "Abdominal pain is an important component of vaso-occlusive painful crisis and may mimic diseases such as acute appendicitis and cholecystitis." | ( Ahmed, S; Kimpo, M; Mattana, J; Russo, L; Siddiqui, AK; Siddiqui, RK, 2003) |
| "Chronic pain is highly prevalent among older people with arthritis, with depression as its major outcome." | ( Moore, C; Palencia, I; Tak, S; Tsai, PF, 2003) |
| "Because pain is the hallmark symptom of OM, the authors sought to determine whether a simple measure of patient-reported pain was correlated with objective, physician-assessed measures of OM." | ( Cella, D; Fuchs, H; Giles, F; Hurd, D; Martin, PJ; Miller, C; Pulliam, J; Sonis, ST; Wingard, JR, 2003) |
| "Pain is the most common and feared symptom for patients, especially those with cancer." | ( Altunay, H; Hasirci, V; Sendil-Keskin, D; Wise, DL, 2003) |
| "Muscle pain is a major clinical problem but the underlying mechanisms and its pharmacological modulation need further investigation." | ( Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Schulte, H; Segerdahl, M; Sollevi, A, 2003) |
| "Chronic pain is a subjective experience and has not only physical, but also psychological and social dimensions." | ( Benetka, G; Kozek-Langenecker, SA; Kress, HG; Langer, G; Sator-Katzenschlager, SM; Schiesser, AW, 2003) |
| "Biliary pain is commonly reported in household surveys with the presumed cause being gallstones." | ( Shaffer, E, 2003) |
| "Instead, referred pain is most likely a consequence of misinterpretation of the origin of input from the stimulated focal pain area, due to excitation of neurones somewhere along the neuroaxis with projected fields in the referred pain area." | ( Hansson, P; Kosek, E, 2003) |
| "Joint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA." | ( Bianchi, M; Broggini, M, 2003) |
| "Chronic pain is debilitating and can greatly decrease quality of life, not just due to the pain per se, but also because of the depression that can often ensue." | ( Assis, TS; Currie, AJ; Kennedy, C; Rowan, EG, 2003) |
| "Pain is common in these patients." | ( Kowalski, MO; Petrone, S; Seaman, JJ; Small, EJ; Smith, MR, 2003) |
| "Chronic pain is often difficult to treat effectively." | ( Fink, DJ; Glorioso, J; Mata, M, 2003) |
| "Pain is a common symptom at the end of life." | ( Moynihan, TJ, 2003) |
| "Pain is a multidimensional conscious experience including sensory and negative affective components." | ( Minami, M; Nakagawa, T; Satoh, M; Tanimoto, S; Yamauchi, Y, 2003) |
| "Although pain is a cardinal feature of pancreatitis, its pathogenesis is poorly understood and treatment remains difficult." | ( He, ZJ; Micci, MA; Pasricha, PJ; Shenoy, M; Toma, H; Winston, JH; Xiao, SY; Zou, L, 2003) |
| "Pain is a protective mechanism for the body; it occurs whenever any tissues are being damaged, and it causes the individual to react to remove the pain stimulus." | ( Becker, DE, 1996) |
| "Pain is among the most common complaints for which people seek medical care; yet pain is also among the most undertreated patient complaints." | ( Heit, HA, 2003) |
| "Pain is a unique class of sensory experience from the perspective of salience." | ( Davis, KD; Downar, J; Mikulis, DJ, 2003) |
| "Pain is a significant problem in more than 50% of HD patients and is not being effectively managed." | ( Davison, SN, 2003) |
| "Chronic malignant pain is experienced by as many as 80% of patients with cancer." | ( Herdon, CM, 2003) |
| "Because pain is a highly common presenting complaint in the ED, EPs are pivotal players in these controversies." | ( Fishman, S; Papazian, J; Rose, JS; Wilsey, B, 2004) |
| "Inflammatory pain is caused by sensitization of peripheral and central nociceptive neurons." | ( Bär, KJ; Ebersberger, A; Natura, G; Schaible, HG; Telleria-Diaz, A; Teschner, P; Vasquez, E; Vogel, R, 2004) |
| "The induction of pain is also a reliable, measurable phenomenon in animals receiving continuous delivery of opioid." | ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Vanderah, TW, 2001) |
| "Pain is an important but understudied and often overlooked aspect of emergency medical care." | ( Leffler, S; McIntosh, SE, 2004) |
| "Pain is a common symptom in advanced disease." | ( Hall, EJ; Sykes, NP, 2004) |
| "This pain is unpredictable and produces fear and anxiety in patients and family members." | ( Ghooi, RB; Ghooi, SR, 2003) |
| "Pain is a complex problem, for both those who are enduring it and those trying to relieve it." | ( Spencer, M, 2003) |
| "Pain is a common experience of mankind." | ( Brunsch, H; Kasper, SM; Radbruch, L; Sabatowski, R; Schäfer, D, 2004) |
| "Breakthrough pain is normally severe in intensity and has a rapid onset." | ( Bianchi, M; Casuccio, A; Ferrera, P; Mercadante, S; Villari, P, 2004) |
| "Chronic pain is frequently associated with profound alterations of neuronal systems involved in pain processing and should be considered as a real disease state of the nervous system." | ( Braz, J; Cesselin, F; Hamon, M; Meunier, A; Pohl, M, 2004) |
| "Deep muscle pain is often associated with sensory changes in the corresponding dermatome." | ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004) |
| "Opioid therapy for pain is the subject of numerous randomized clinical trials." | ( Chevlen, E, 2004) |
| "Pain is a common reason to attend hospital but it is often inadequately managed." | ( Butcher, D, 2004) |
| "Pain is probably one of the most common cancer symptoms." | ( Mucksavage, JJ; Slavin, KV; Tesoro, EP, 2004) |
| "Geriatric pain is a significant problem in health care, because of multiple disease processes in this aged population their population will increase." | ( Ozyalçin, NS, 2004) |
| "Pain is commonplace in newborn infants." | ( Katz, J; Taddio, A, 2004) |
| "Chronic pain is often complicated by a variety of psychiatric conditions that make it difficult to engage and treat patients." | ( Clark, MR; Treisman, GJ, 2004) |
| "Pain is an unpleasant sensation." | ( Sudhakar, HH; Venkatesh, D, 2003) |
| "That facial pain is associated with neuroplastic changes within the somatic cortical representation of the hand suggests a pain-related topographic cortical reorganisation." | ( Aglioti, SM; Fiaschi, A; Moretto, G; Nicolato, A; Rosso, T; Tinazzi, M; Valeriani, M, 2004) |
| "Pain is frequently encountered in outpatient oncology practice and its management often is inadequate." | ( Chandran, N; Koshy, RC; Kuriakose, R; Mathew, A, 2004) |
| "Neuropathic pain is a prominent feature of CRPS I, and is often refractory to treatment." | ( Kessels, AH; Stomp-van den Berg, SG; van de Vusse, AC; Weber, WE, 2004) |
| "Pain is a common problem in both adults and children with Guillain-Barré Syndrome (GBS)." | ( Boukhris, S; Kabore, R; Lacoste, M; Mabrouk, T; Magy, L; Vallat, JM, 2004) |
| "Cancer pain is a major problem for cancer patients, as about 80 percent patients with advanced cancer declare pain as their main symptom." | ( Skorupskiene, D, 2004) |
| "Visceral pain is one of the most common forms of pain which is poorly understood." | ( Hosseini, AR; Khansefid, N; Sabetkasaie, M; Sadat Ladgevardi, MA; Vala, S, 2004) |
| "Bone pain is a frequent complication of metastatic bone disease, with severe consequences for patient mobility and quality of life." | ( Body, JJ; Heidenreich, A; Ohlmann, C, 2004) |
| "Breakthrough pain is a transitory flare of pain superimposed on an otherwise stable pain pattern in patients treated with opioids." | ( Casuccio, A; Ferrera, P; Mercadante, S; Villari, P, 2004) |
| "Persistent pain is present to some degree throughout the day and primarily is controlled with around-the-clock medication." | ( Palos, G; Rhiner, M; Termini, M, 2004) |
| "Muscle pain is often accompanied by a feeling of muscle fatigue and weakness." | ( Bach, FW; Fuglsang-Frederiksen, A; Jensen, TS; Kasch, H; Qerama, E, 2005) |
| "Pain is one of the presenting symptoms in acute neuroborreliosis." | ( Berthele, A; Tölle, TR, 2004) |
| "Heel pain is one of the most common presenting complaints to the foot and ankle specialist." | ( Burns, PR; Lowery, C; Scanlan, RL; Zgonis, T, 2005) |
| "Long-standing groin pain is a persistent problem that is commonly difficult to rehabilitate." | ( Bennell, KL; Brukner, P; Coburn, P; Cowan, SM; Crossley, KM; Hodges, PW; Schache, AG, 2004) |
| "Neuropathic pain is one of the important microvascular complications of diabetes." | ( Anjaneyulu, M; Chopra, K, 2004) |
| "Because itch and pain are carried by small nerve fibers, abnormal function of these fibers could be an explanation for such phenomena." | ( Chan, YH; Goh, CL; Lee, SS; Yosipovitch, G, 2004) |
| "Itch and pain are common presentations in keloids and are associated with abnormalities in small nerve fiber function, suggesting a small nerve fiber neuropathy." | ( Chan, YH; Goh, CL; Lee, SS; Yosipovitch, G, 2004) |
| "Breast pain is a common symptom in patients attending breast clinics." | ( Gateley, C; Goyal, A; Kubista, E; Leinster, S; Maddox, PR; Mansel, RE; Preece, P; von Fournier, D, 2004) |
| "In elderly persons, pain is a common problem, and analgesic medicines are among the most frequently used drugs." | ( Hartikainen, SA; Louhivuori-Laako, KA; Mäntyselkä, PT; Sulkava, RO, 2005) |
| "Bone cancer pain is usually progressive as the disease advances, and is particularly difficult to treat." | ( Clohisy, DR; Mantyh, PW, 2004) |
| "Cancer-induced bone pain is a major clinical problem for which current treatments lack full efficacy." | ( Dickenson, AH; Donovan-Rodriguez, T; Urch, CE, 2005) |
| "Pain is a determining factor in patient acceptability of outpatient hysteroscopy and is a likely reason for some women to opt to have a hysteroscopy under general anesthesia." | ( Brown, V; Dass, M; Jivraj, S; Panikkar, J, 2004) |
| "Acute pain is a common presentation associated with opioid seeking behaviour." | ( Hulse, GK; Khong, E; Sim, MG, 2004) |
| "Neuropathic pain is a syndrome that affects around 1% of population." | ( Espinoza-Raya, J; Granados-Soto, V; Medina-Santillán, R; Morales-Franco, G; Reyes-García, G, 2004) |
| "Chronic non-cancer pain is a common problem that is often accompanied by psychiatric comorbidity and disability." | ( Bryant, ME; Chelminski, PR; DeWalt, DA; Felix, KM; Ives, TJ; Malone, RM; Miller, TM; Perhac, JS; Pignone, MP; Prakken, SD, 2005) |
| "Leg pain is a common symptom in dialysis patients." | ( Dudler, J; Lobrinus, JA; Revaz, S; So, AK; Theumann, N, 2005) |
| "Evaluation of pain is subjective, and the severity of pain experienced in the control, vehicle-treated eyes was low." | ( Price, FW; Price, MO, 2004) |
| "Orgasmic pain is an infrequently reported but distressing problem for the patients who experience it." | ( Barnas, J; Guhring, P; Mulhall, JP; Parker, M, 2005) |
| "Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research." | ( Caterina, M; Gu, J; MacDermott, AB; Malmberg, A; Neugebauer, V; Yoshimura, M; Zhuo, M, 2005) |
| "Chronic pain is known to affect and to be affected by neuroendocrine and immune mechanisms." | ( Aloisi, AM; Ceccarelli, I; Ietta, F; Lodi, L; Pari, G; Paulesu, L; Vecchi, I, 2005) |
| "Anterior knee pain is one of the most common orthopedic complaints affecting the knee." | ( Horton, P; Propps, M; Ratner, J; Smith, SS; Watson, CJ; Zeigler, DL, 2005) |
| "Injection pain is a well-known adverse effect of propofol which distresses patients." | ( Fujii, Y; Nakayama, M, 2005) |
| "Pain is commonly associated with inflammation." | ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "Pain is intimately linked with action systems that are involved in observational learning and imitation." | ( Aglioti, SM; Avenanti, A; Bueti, D; Galati, G, 2005) |
| "However, chronic pain is associated with physiological and psychosocial complexities that may also explain the results." | ( Henry, ML; Moseley, GL; Sim, DF; Souvlis, T, 2005) |
| "Indeed, phasic pain is often associated with differential or opposing effects to tonic pain in behavioral, lesion, and pharmacological studies." | ( Dolan, RJ; Driver, J; Kalisch, R; Koltzenburg, M; Seymour, B; Stephan, KE; Wiech, K, 2005) |
| "Chronic pain is associated with motor dysfunctions, and stimulation of the motor cortex has been shown to alleviate chronic pain." | ( Polácek, H; Stancák, A; Vrána, J, 2005) |
| "Pain is a cardinal symptom in 70 % of cancer patients." | ( Harzmann, R; Weckermann, D, 2005) |
| "Chronic pain is a frequent cause of suffering and disability that negatively affects patients' quality of life." | ( Calleson, D; Carey, T; Chen, I; Cykert, S; Faselis, C; Genao, I; Kurz, J; Mechaber, AJ; Menon, M; O'Rorke, J; Panda, M; Pasanen, M; Rosenberg, E; Staton, LJ; Wood, J, 2005) |
| "Formalin-induced pain is reduced in sigma-1 (sigma1) receptor knockout mice; therefore, we hypothesized that haloperidol and its metabolites I and II, which have affinity for sigma1 receptors, may modulate formalin-induced pain." | ( Baeyens, JM; Cendán, CM; Portillo-Salido, E; Pujalte, JM, 2005) |
| "Neuropathic pain is a neuropsychiatric condition in which pain is initiated or caused by a primary lesion or dysfunction in the nervous system." | ( Hainline, B, 2005) |
| "Neuropathic pain is characterised by hyperexcitability within nociceptive pathways that manifests behaviourally as allodynia and hyperalgesia and remains difficult to treat with standard analgesics." | ( Blackburn-Munro, G; Nielsen, AN; Pedersen, LH, 2005) |
| "Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, allodynia and hyperalgesia." | ( Castañé, A; Célérier, E; Ledent, C; Maldonado, R; Martín, M; Parmentier, M; Valverde, O, 2006) |
| "Chronic pain is common, and many people suffer from chronic pain conditions involving deep craniofacial tissues such as temporomandibular disorders or fibromyalgia." | ( Cairns, BE; Hu, JW; Lam, DK; Sessle, BJ, 2005) |
| "Pain is still an actual problem in dentistry, and a usage of anaesthetics can be still limited, so new ways of caries treatment are still being searched in order to ease this process both to a patient and a doctor." | ( Balciuniene, I; Juskiene, I; Sabalaite, R, 2005) |
| "Cancer pain is a significant clinical problem because it is the first symptom of disease in 20% to 50% of all cancer patients, and 75% to 90% of patients with advanced or terminal cancer must cope with chronic pain syndromes related to failed treatment and/or tumor progression." | ( Ghilardi, JR; Halvorson, KG; Kubota, K; Lindsay, TH; Mantyh, PW; Sevcik, MA, 2005) |
| "The injection pain is less at the brachial region than the wrist or the hand." | ( Hoka, S; Inamura, M; Isono, M; Kanai, A; Kosaka, Y; Nakano, T; Nomiyama, S; Okamoto, H; Ozawa, A; Ueno, T, 2005) |
| "However, if pain is unmanageable in the outpatient department, we believe that options include hospital admission, using the contained method of application or, in the worst case scenario, cessation of treatment." | ( Budding, T; Oskam, J; Steenvoorde, P, 2005) |
| "Relief of chronic pain is an important clinical problem requiring special care and approaches." | ( Hasirci, V; Keskin, DS; Wise, DL, 2004) |
| "Jaw pain is present in about 19% of patients with RA and OA, and is primarily a marker for a general pain increase and symptom sensitivity problem." | ( Katz, RS; Michaud, K; Wolfe, F, 2005) |
| "Familial rectal pain is a very rare entity that must always be considered as a possible aetiology of any life-threatening event in an infant because of the availability of a very effective treatment." | ( Arbuès, AS; Bednarek, N; Morville, P; Motte, J; Plouin, P; Sabouraud, P, 2005) |
| "Bone cancer pain is mostly associated with an inflammatory response dominated by local activation of osteoclasts and by astrogliosis in the spinal cord." | ( Beitz, A; Eikmeier, L; Fike, JR; Jasmin, L; Ohara, PT; Tien, DA; Vit, JP; Wilcox, GL, 2006) |
| "Chronic pain is common in patients with spinal cord injury (SCI)." | ( Chiodo, A, 2005) |
| "Musculoskeletal pain is a major clinical problem." | ( Grass, S; Graven-Nielsen, T; Schulte, H; Segerdahl, M, 2006) |
| "Pain is one of the most common reasons patients seek dental treatment." | ( Abbott, PV; Hargreaves, K, 2005) |
| "Neuropathic pain is a common and potentially treatable cause of considerable lifelong morbidity." | ( Baillie, JK; Power, I, 2006) |
| "Chronic pain is a major health problem in the United States affecting 50 to 75 million Americans." | ( Ineck, JR; Rule, AM; Wilken, M, 2005) |
| "Breakthrough pain is a transient increase in pain intensity over background pain." | ( Ribeiro, MD; Zeppetella, G, 2006) |
| "Muscle pain is different from cutaneous pain in its characteristics as well as conducting fibers." | ( Ko, SW; Petrovic, MJ; Sluka, KA; Vadakkan, KI; Wang, H; Zastepa, E; Zhuo, M, 2006) |
| "Neuropathic pain is a condition affecting a significant proportion of the world's population." | ( López-Trigo, J; Sancho Rieger, J, 2006) |
| "Pain is among the most frequently reported, bothersome, and disabling symptoms described by patients with osteoarthritis, rheumatoid arthritis, fibromyalgia, and other musculoskeletal conditions." | ( Bathon, J; Bingham, CO; Edwards, RR; Haythornthwaite, JA, 2006) |
| "Joint pain is the clinical feature of OA that most often leads the affected individual to seek medical attention." | ( Brandt, KD; Buckwalter, KA; Mazzuca, SA, 2006) |
| "Chronic pain is a chronic disease and, like diabetes or hypertension, requires chronic concessions and lifestyle modifications." | ( Bloodworth, D, 2006) |
| "Currently, pain is inadequately managed." | ( Bennett, KC; Dunlop, RJ, 2006) |
| "Inflammatory pain is linked to sensitization of sensory proteins at the nociceptive endings whereas pain originating from nerve damage (neuropathic pain) has been linked to changes in axonal ion channels producing ectopic discharge in nociceptors as a source of pain." | ( Schaible, HG; Schmelz, M; Tegeder, I, 2006) |
| "Pain is an unpleasant sensory experience commonly produced by damage to bodily tissues and it is one of the most significant public health problems, because 21." | ( Al Malyan, M; Ashammakhi, N; Becchi, C; Boncinelli, S; Chiellini, F; Nikkola, L; Viitanen, P, 2006) |
| "Both, pruritus and pain are aversive, but clearly distinct sensations originating in the peripheral and central nervous system." | ( Schmelz, M; Ständer, S, 2006) |
| "Pain is the most debilitating symptom in osteoarthritis of the knee (OAK)." | ( Bjordal, JM; Klovning, A; Ljunggren, AE; Slørdal, L, 2007) |
| "Pain is a major quality issue." | ( Degenholtz, H; Fischberg, D; Litke, A; Maroney-Galin, C; Meier, DE; Moore, C; Morrison, RS; Siu, AL, 2006) |
| "When the pain is intractable and the eye has very poor vision and is disfigured, surgical removal of the eye has traditionally been the definitive treatment of choice." | ( Merbs, SL, 2006) |
| "Given that neck pain is very common in primary headache disorders, this convergent excitation may play a role in pain referral from cervical structures." | ( Akerman, S; Bergerot, A; Classey, JD; Goadsby, PJ; Holland, PR; Knight, YE; Lasalandra, MP; Le Doaré, K, 2006) |
| "Although pain is a common patient complaint in emergency departments, many people receive no analgesia." | ( Costello, M; Grammas, M; Heins, A; Heins, JK; Huang, K; Mishra, S, 2006) |
| "Pain is not the most frequent symptom in cancer patients, but it is considered the most serious and threatening symptom." | ( Eriksen, J; Lundorff, LE; Sjøgren, P, 2006) |
| "Neuropathic pain is associated with a number of disease states of diverse aetiology that can share common pathophysiological mechanisms." | ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "Pain is a complicated phenomenon." | ( Collins, JJ; McCulloch, R, 2006) |
| "Neuropathic pain is often a consequence of nerve injury through surgery, bone compression, cancer, diabetes or infection." | ( Inoue, K, 2006) |
| "Pain is usually accompanied by limited mobility of the shoulder and sometimes by swelling of the hand and wrist." | ( Zyluk, A; Zyluk, B, 2006) |
| "Pain is a well-known complication of intravenous administration of propofol, and to find out the optimal method to decrease this pain, we studied 4 methods of delivering propofol." | ( Abu-Ali, HM; Abu-Halaweh, SA; Badran, IZ; Massad, IM, 2006) |
| "Chronic pain is a costly and prevalent problem." | ( Wallace, JM, 2006) |
| "Neuropathic pain is a common symptom in many diseases of the peripheral nervous system." | ( Cornblath, DR; Dühmke, RM; Hollingshead, J, 2006) |
| "Chronic pain is defined as intractable pain caused by abnormal pain transmission or impairment of the pain control system per se." | ( Fujita, S; Futami, S; Kodama, T; Kunitake, A; Nagamachi, S; Nishii, R; Takasaki, M; Tamura, S; Uno, T; Wakamatsu, H; Yano, T, 2006) |
| "Breakthrough pain is well-characterized in cancer patients but not in patients with chronic noncancer pain." | ( Bennett, DS; Brennan, M; Portenoy, RK; Rauck, R; Shoemaker, S; Simon, S; Taylor, D, 2006) |
| "Breakthrough pain is a common problem in patients with cancer, and is associated with significant morbidity among this group of patients." | ( Davies, AN, 2006) |
| "Chronic pain is common after a traumatic brain injury." | ( Drance, E; Gallagher, R; Higginbotham, S, 2006) |
| "Chronic pain is a major problem for the individual and for society." | ( Bountra, C; Schweinhardt, P; Tracey, I, 2006) |
| "Pain is a universal complaint, which needs further investigations for new pain relieving agents." | ( Dashti-Rahmatabadi, MH; Hejazian, SH; Morshedi, A; Rafati, A, 2007) |
| "Joint pain is a primary symptom in knee osteoarthritis (OA), but the effect of pain and pain relief on the knee joint mechanics of walking is not clear." | ( Alkjaer, T; Bliddal, H; Danneskiold-Samsøe, B; Graven-Nielsen, T; Henriksen, M; Lund, H; Simonsen, EB, 2006) |
| "Pain is a complex experience, involving both the physiological responses of the nociceptive system and the processing of that information in brain regions associated with emotion." | ( Desaiah, D; Perahia, DG; Pritchett, YL; Raskin, J, 2006) |
| "Breast pain is a common complaint among lactating women." | ( McKenna, DS; Page, SM, 2006) |
| "Pain is a common and feared problem for those with advanced cancer." | ( Auret, K; Pickstock, S, 2006) |
| "Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system." | ( Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J, 2006) |
| "Chronic neuropathic pain is estimated to affect up to 8% of the world's population; the numerous analgesic compounds currently available are largely ineffective and act through a small number of pharmacological mechanisms." | ( Ellison, M; McIntosh, JM; Olivera, BM; Parker, R; Vincler, M; Wittenauer, S, 2006) |
| "Pain is developed in the trapezius and masseter muscles during repeated isometric contraction." | ( Brodda Jansen, G; Ernberg, M; Hedenberg-Magnusson, B; Kopp, S, 2006) |
| "Pain is a common symptom in many somatic illnesses." | ( Hajak, G, 2006) |
| "Radiation of pain is a perplexing clinical problem." | ( Coghill, RC; Quevedo, AS, 2007) |
| "Pain is the most common discomfort experienced by children with cancer and occurs in almost 89% of patients in an advanced stage of the disease." | ( Barone, G; Chiaretti, A; Lazzareschi, I; Liotti, L; Riccardi, R; Ruggiero, A, 2007) |
| "Pain is a complex human trait." | ( Bhat, SV; Bruera, E; Kaasa, S; Klepstad, P; Rakvåg, T; Reyes-Gibby, CC; Shete, S; Skorpen, F, 2007) |
| "Pain is regarded as a risk factor in pressure ulcer development by contributing to immobility." | ( Baron, C; Fromy, B; Leftheriotis, G; Roquelaure, Y; Saumet, JL; Sigaudo-Roussel, D, 2007) |
| "Neuropathic pain is emerging as a major complication of bortezomib." | ( Burton, AW; Cata, JP; Dougherty, PM; Giralt, S; Villareal, H; Weng, HR, 2007) |
| "Pain is the major reason patients seek medical care." | ( Okuse, K, 2007) |
| "Spontaneous pain is the chief clinical manifestation of peripheral nerve injury; however, a role for I(h) in spontaneous pain has not been described." | ( Ao, H; Brown, SM; Chang, L; Chaplan, SR; Dubin, AE; Higuera, ES; Lee, DH; Luo, L, 2007) |
| "The reason for the pain is assumed to be the aqueous phase of the propofol emulsion." | ( Boulaadass, S; Gräf, G; Mencke, T; Molter, GP; Silomon, M; Soltész, S, 2007) |
| "Testicular pain is rarely caused by medications." | ( Hiatt, WH; Linnebur, SA, 2007) |
| "As severe pain is most common and dreadful symptom in cancer patients, all physicians should learn correct information about opioid analgesics." | ( Kimura, N; Noguchi, T, 2007) |
| "Chronic non-cancer pain is an increasing problem in health care." | ( Blake, S; Ruel, B; Seamark, C; Seamark, D, 2007) |
| "Chronic non-cancer pain is associated with high levels of distress and psychosocial impairment." | ( Blake, S; Ruel, B; Seamark, C; Seamark, D, 2007) |
| "Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain." | ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007) |
| "Treating ischemic pain is often unsatisfactory." | ( Irnich, D; Lang, PM, 2007) |
| "Pain is a common symptom and significant problem for older adults; up to one half of community-dwelling older adults have pain that interferes with normal function." | ( Allman, RM; Bodner, EV; Ritchie, CS; Sawyer, P, 2006) |
| "Breakthrough pain is a prevalent and serious problem in patients with cancer." | ( Farrar, JT; Fisher, K; Hagen, NA; Victorino, C, 2007) |
| "The ejaculatory pain is associated with prostatitis, chronic pelvic pain syndrome, benign prostatic hyperplasia, and ejaculatory duct obstruction; it is also described in patients after procedures like radical prostatectomy." | ( Ilie, CP; Mischianu, DL; Pemberton, RJ, 2007) |
| "Since pain is the main syndrome of dysmenorrhea, the present investigation was carried out to evaluate the analgesic activity of LIG in vivo." | ( Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L, 2007) |
| "Chronic muscle pain is a problem with high prevalence in clinical practice and its pharmacological treatment is difficult." | ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007) |
| "Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes." | ( Aloisi, AM; Bachiocco, V; Bertaccini, A; Ceccarelli, I; Costantino, A; Meriggiola, MC; Stefani, R, 2007) |
| "The assessment of pain is of critical importance for mechanistic studies as well as for the validation of drug targets." | ( Adwanikar, H; Fu, Y; Han, JS; Ji, G; Neugebauer, V, 2007) |
| "Although pain is a frequent feature in patients with cancer, its etiology is still poorly understood." | ( De Hert, S; Deseure, K; Hans, G; Robert, D, 2007) |
| "Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients." | ( Alkjaer, T; Bliddal, H; Danneskiold-Samsøe, B; Graven-Nielsen, T; Henriksen, M; Lund, H; Simonsen, EB, 2007) |
| "Anticipation to pain is thought to increase the suffering of chronic pain patients." | ( Lujan, BJ; Peskett, GD; Rogers, R; Schweinhardt, P; Tracey, I; Wise, RG, 2007) |
| "Pain is a public health disaster." | ( Lipman, AG, 2007) |
| "Although acute pain is frequently reported by patients admitted to the emergency room, it is often insufficiently evaluated by physicians and is thus undertreated." | ( Blanc, C; Buclin, T; Decosterd, I; Givel, JC; Hugli, O; Mouhsine, E; Tamchès, E; Yersin, B, 2007) |
| "Severe acute pain is common in sickle cell disease (SCD)." | ( Adewoye, AH; Ma, Q; McMahon, L; Nolan, V; Steinberg, MH, 2007) |
| "Dyspnea and pain are similarly unpleasant, alarming physical sensations, but studies examining both sensations in combination are lacking." | ( Dahme, B; von Leupoldt, A, 2007) |
| "Background pain is treated with long-acting opioids." | ( Christrup, LL; Hansen, OB; Højsted, J; Jarvig, L; Jensen, NH; Jonsson, T; Olesen, AE; Sjøgren, P; Sonne, NM; Sørensen, JT, 2007) |
| "Pain is the most distressing symptom in patients with breast carcinoma and can occur at all stages of the disease due to the cancer per se as well as due to various diagnostic and treatment modalities." | ( Kumar, S; Saxena, AK, 2007) |
| "Nociceptive cancer pain is characterized by its frequent instability." | ( Binhas, M; Krakowski, I; Marty, J, 2007) |
| "Pain is the most prominent feature of IC and current therapies provide limited relief." | ( Leventhal, L; Piesla, M; Wantuch, C, 2007) |
| "Propofol injection pain is a well-known problem in pediatric anesthesia." | ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007) |
| "Pain is a multistep process that originates in the peripheral nervous system at the site of injury, is transmitted and processed within the central nervous system, and is perceived at the level of the cerebral cortex." | ( Gordon, SM, 2007) |
| "Pain is a major issue for patients suffering from many different types of wounds in particular those with burn injuries." | ( Cleland, H; Wasiak, J, 2007) |
| "Cancer pain is a prevalent and serious public health issue, and more effective treatments are needed." | ( Chary, S; du Souich, P; Fisher, KM; Hagen, NA; Lapointe, B; Moulin, D; Ngoc, AH; Sellers, E, 2007) |
| "Chronic pain is maintained in part by long-lasting neuroplastic changes in synapses and several proteins critical for synaptic plasticity are degraded by the ubiquitin-proteasome system (UPS)." | ( Bakalkin, G; Bazov, I; Ekström, TJ; Gardell, LR; Kowal, J; Ossipov, MH; Porreca, F; Usynin, I; Yakovleva, T, 2007) |
| "Neuropathic pain is notoriously difficult to manage and only a few classes of drugs may provide adequate benefits." | ( Lind, G; Linderoth, B; Schechtmann, G; Winter, J, 2007) |
| "Visceral pain is one of the most common forms of pain and for which new drugs would be welcome." | ( Meymandi, MS; Sepehri, G, 2008) |
| "Pain is experienced by most cancer patients and represents an important issue in the clinical setting." | ( Mystakidou, K; Tsiatas, M; Tsilika, E; Vlahos, L, 2007) |
| "Pain is often considered an expected concomitant of aging, and older patients are considered more sensitive to opioids." | ( Arcuri, E; Mercadante, S, 2007) |
| "Immunization pain is a global public health issue." | ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007) |
| "Pain is a common problem, and has been both under-recognized and under-treated." | ( Chai, MO; Donohoe, P; Edmonds, PM; Higginson, IJ; Murtagh, FE, 2007) |
| "WHO declared that pain is a relevant problem in public health and that opioids are the gold standard therapy for the treatment of moderate to severe pain." | ( Chinellato, A; Giusti, P; Roggeri, D; Saramin, C; Terrazzani, G; Zusso, M, 2007) |
| "Pain is a common symptom experienced by people with osteoarthritis and rheumatoid arthritis and impacts upon mobility and quality of life." | ( While, A; Ying, KN, 2007) |
| "Pain is an unpleasant sensation that originates from ongoing or impending tissue damage." | ( Beaulieu, P; Guindon, J; Walczak, JS, 2007) |
| "Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family." | ( Friedrichsdorf, SJ; Kang, TI, 2007) |
| "clinical pain are summarized." | ( Craft, RM, 2007) |
| "Pain is the insignia of sickle cell disease and the acute painful crisis is the number-one cause of hospital admissions." | ( Ballas, SK, 2007) |
| "As pain is very dynamic, close monitoring is recommended." | ( Jensen, NH; Lundorff, LE, 2007) |
| "Relief of pain is an important issue for nurses." | ( Burke, D; Johnson, H; Newell, R; Parapia, L; Plews, C, 2008) |
| "The treatment of pain is definitely the main priority." | ( Lukas, A, 2007) |
| "The causes of this pain are unknown, but are likely to involve the action of tumour-associated mediators and their receptors." | ( Adriaensen, H; Deseure, K; Hans, G, 2008) |
| "Pain is one of the symptoms that many tumor patients are especially afraid of in the final phase of their illness." | ( Maier, A; Maier, R; Müller-Busch, C, 2008) |
| "Cancer pain is a serious public health issue and more effective treatments are needed." | ( du Souich, P; Dubuc, B; Hagen, NA; Lapointe, B; Love, R; Ngoc, AH; Ong-Lam, M; Walde, D, 2008) |
| "Pain is a common symptom for patients with cancer, and opioids are the treatment of choice for moderate or severe cancer-related pain." | ( du Bois, RM; Gretton, S; Riley, J; Ross, JR; Sato, H; Taegetmeyer, AB; Welsh, KI, 2008) |
| "Breakthrough pain is a common and distinct component of cancer pain that is usually managed with normal release opioids (also known as rescue medication) either before or soon after its onset." | ( Zeppetella, G, 2008) |
| "Pain is experienced by a majority of cancer patients." | ( Kumar, MG; Lin, S, 2007) |
| "Sensitivity to pain is reduced during exercise." | ( Edwards, L; Kavussanu, M; Ring, C, 2008) |
| "Pain is the primary presenting symptom in the vast majority of inflammatory and noninflammatory rheumatic diseases." | ( Crofford, LJ, 2008) |
| "Currently, bone pain is treated primarily by opioid-based therapies, which are frequently accompanied by significant unwanted side effects." | ( Bauss, F; Ghilardi, JR; Halvorson, KG; Koewler, NJ; Mantyh, PW; Sevcik, MA; Sullivan, LJ, 2008) |
| "Pain is a complex experience composed of sensory and emotional components." | ( Minami, M, 2008) |
| "Chronic pain is the main symptom of postmenopausal osteoporosis." | ( Buttgereit, F; Krocker, D; Perka, C; Ullrich, H, 2008) |
| "Cancer pain is generally moderate to severe in intensity and persistent in nature." | ( Macleod, R; William, L, 2008) |
| "Therefore, pain is independent of pathology and inflammation, and histamine receptors represent direct therapeutic targets for pain in IC and other chronic pain conditions." | ( Berry, RE; Bryce, PJ; Guichelaar, LA; Klumpp, DJ; Rudick, CN, 2008) |
| "Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain." | ( Jiang, YQ; Sun, Q; Tu, HY; Wan, Y, 2008) |
| "Chronic abdominal pain is a common gastrointestinal symptom experienced by patients." | ( Price, DD; Verne, NG; Zhou, Q, 2008) |
| "Pain is a common symptom among cancer patients, yet many patients do not receive adequate pain management." | ( Hampshire, MK; Metz, JM; Simone, CB; Vapiwala, N, 2008) |
| "Pain is a problem in critically ill patients." | ( Alfaro, CG; González, PI; Hazaña, FH; Roldán, JM, 2008) |
| "Although sciatic pain is typically self-limiting, pharmacological analgesic therapy forms the mainstay of treatment." | ( Loiero, M; Memeo, A, 2008) |
| "Opioid-refractory pain is distressing because it is notoriously difficult to treat." | ( Haji, AG; Jain, D; Palat, G; Rajagopal, MR; Sharma, S; Singh, C, 2009) |
| "Chronic pain is the most difficult type of pain to treat." | ( DeLeo, JA; Horvath, RJ; Romero-Sandoval, EA, 2008) |
| "Self-reporting of pain is considered to be the primary source of information on pain intensity for older children but a validated observational tool will provide augment information to self-reports during painful procedures." | ( Finnström, B; Kokinsky, E; Nilsson, S, 2008) |
| "Although chronic pain is common, especially in elderly patients, its treatment often remains inadequate." | ( Birklein, F; May, A; Sternberg, S, 2008) |
| "Pain is the most common symptom in the world for which patients seek professional help." | ( Katz, WA, 2008) |
| "Neuropathic pain is challenging to treat, partly because of the systemic side effects of the commonly used medications." | ( Besson, M; Desmeules, J; Piguet, V, 2008) |
| "Chronic pain is now viewed as a biopsychosocial phenomenon, in which biological, psychological, and social factors are at work." | ( Forde, G; Stanos, S, 2007) |
| "Neuropathic pain is a chronic pain condition arising from injury or disease of the peripheral or central nervous system with a substantial impact on quality of life." | ( Finnerup, NB; Jensen, TS, 2007) |
| "Post-inflammatory pain is a poorly understood phenomenon." | ( Eijkelkamp, N; Elsenbruch, S; Heijnen, CJ; Holtmann, G; Kavelaars, A; Schedlowski, M, 2009) |
| "Severe pain is the leading symptom and many patients with ALDS are unable to tolerate compression therapy." | ( Medenica, LJ; Pavlović, MD; Vesić, S; Vuković, J, 2008) |
| "Pain is an experience that affects all aspects of a patient's life and effective pain management with strong opioids may help the patient to focus on the positive aspects of life, decreasing the focus on pain." | ( Cwiek, R; Gasik, R; Lisowska, B, 2008) |
| "Metastatic bone pain is characteristic of cancer pain." | ( Hara, S, 2008) |
| "Breast pain is a common symptom in patients attending breast clinics." | ( Ebrahimi, M; Hashemi, ES; Hooshmand, H; Izadi, S; Kaviani, A; Mehrdad, N; Najafi, M; Yunesian, M, 2008) |
| "Breast pain is a complex symptom that can be relieved significantly with reassurance." | ( Ebrahimi, M; Hashemi, ES; Hooshmand, H; Izadi, S; Kaviani, A; Mehrdad, N; Najafi, M; Yunesian, M, 2008) |
| "Pain is an unpleasant sensory and emotional experience." | ( Deyama, S; Kaneko, S; Katayama, T; Kondoh, N; Minami, M; Nakagawa, T; Yamaguchi, T; Yoshioka, M, 2009) |
| "Intrusive pain is likely to have a serious impact on older people with limited ability to respond to additional stressors." | ( Blyth, FM; Couteur, DGL; Creasey, H; Cumming, RG; Handelsman, DJ; Naganathan, V; Rochat, S; Sambrook, PN; Seibel, MJ; Waite, LM, 2008) |
| "Pain is now the "5th vital sign" and physicians face disciplinary action for failure to adequately relieve pain." | ( Flower, K; Galloway, GP; Mendelson, J; Pletcher, MJ, 2008) |
| "Chronic pain is one of the most frequent and distressing symptoms in patients suffering from bone metastases due to malignant disease." | ( Fischer, M; Kampen, WU, 2008) |
| "Arthritic pain is a common and disabling problem for many older adults." | ( Doherty, JB; Yoon, E, 2008) |
| "Clinically, pain is a complex phenomenon consisting of both sensory and affective aberrations that can persist indefinitely." | ( Cummons, TA; Hummel, M; Lu, P; Whiteside, GT, 2008) |
| "Pain is an important and often under-treated symptom of life-threatening illness." | ( Mathieu, N; Tuna, T, 2008) |
| "Pain is the result of an emotional and sensory experience and preclinical models of OA can thus be useful to better understand the underlying mechanisms of the disease and test new therapeutic options." | ( Dickenson, AH; Ghandehari, J; Vonsy, JL, 2009) |
| "neuropathic pain) is not very satisfactorily managed." | ( Fürst, Z, 2008) |
| "Osteoarthritis pain is a significant problem for our aging population." | ( Bentley, S; Fan, MY; Gardner, G; Sullivan, MD, 2009) |
| "Chronic pain is difficult to diagnose and treat, and is often comorbid with psychiatric conditions." | ( Arnold, LM; Glazer, WM; Jain, R, 2008) |
| "Deficiencies in pain care within the developing world are starting to be realized." | ( Boonyawatanangkool, K; Evans, J; Finley, GA; Forgeron, PA; Jongudomkarn, D; Pairojkul, S; Siripul, P; Sriraj, W; Thienthong, S, 2009) |
| "However, chronic pain is practically useless and leads to psychopathological changes." | ( Murányi, M; Radák, Z, 2008) |
| "Neuropathic pain is a disease caused by a lesion or dysfunction of the nervous system." | ( Barrot, M; Doridot, S; Freund-Mercier, MJ; Hein, L; Petit-Demoulière, N; Tessier, LH; Yalcin, I, 2009) |
| "Pain is associated with swallowing abnormalities in dysphagic patients." | ( Iwata, K; Kitagawa, J; Tsujimura, T; Ueda, K, 2009) |
| "Since pain is permanent, the continuous administration of the analgesic is recommended rather than an on demand administration." | ( Faymonville, ME; Libbrecht, D, 2008) |
| "Pain is a physiological state promoting protective responses to harmful episodes." | ( Cohen, A; Sagron, R; Segal-Hayoun, Y; Somech, E; Zilberberg, N, 2009) |
| "Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood." | ( Andresen, T; Christrup, LL; Olesen, AE; Upton, RN, 2009) |
| "Gout and pain are synonymous, and a study in this issue of the BJP reports a novel anti-nociceptive effect of allopurinol, the drug most commonly used to treat gout." | ( Connor, M, 2009) |
| "Pain is the most common complaint in the medical field and the identification of compounds that can effectively treat painful states without induction of side-effects remains a major challenge in biomedical research." | ( Bonacorso, HG; Cechinel, CA; Dalmolin, GD; Ferreira, J; Gewehr, C; Lourega, RV; Martins, MA; Oliveira, SM; Rubin, MA; Sehnem, RC; Wentz, A; Zanatta, N, 2009) |
| "Chronic noncancer pain is common and use of opioids is increasing." | ( Ballantyne, JC; Chou, R; Fanciullo, GJ; Fine, PG; Miaskowski, C, 2009) |
| "Cancer pain is often labeled as mixed mechanism pain and is not easily classified as exclusively nociceptive or NP." | ( Aielli, F; Casuccio, A; David, F; Ferrera, P; Gebbia, V; Mangione, S; Mercadante, S; Porzio, G; Verna, L, 2009) |
| "Pain is the main acute adverse event during photodynamic therapy of skin lesions." | ( Haedersdal, M; Wiegell, SR; Wulf, HC, 2009) |
| "In inflammation, pain is regulated by a balance of pro- and analgesic mediators." | ( Brack, A; Hackel, D; Labuz, D; Mousa, S; Rittner, HL; Schaefer, M; Schäfer, M; Stein, C; Stolz, A; Voigt, P, 2009) |
| "Pain is a common symptom that patients describe and clinicians have to manage." | ( Bennett, MI; Cawley, D, 2009) |
| "Breakthrough pain is a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain." | ( Zeppetella, G, 2009) |
| "Referred pain is a significant clinical problem, and commonly occurs with pain originating in muscle but not from skin." | ( Gandevia, SC; Henderson, LA; Macefield, VG; Rubin, TK, 2009) |
| "Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids." | ( Imai, T; Inoue, K; Nagata, K; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T, 2009) |
| "Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients." | ( Kim, JS, 2009) |
| "Pain is frequently reported by patients with Parkinson's disease (PD)." | ( Ebersbach, G; Nebe, A, 2009) |
| "Iatrogenic pain is a serious problem, particularly in preterm infants of low gestational age." | ( Büchi, S; Cignacco, E; Hamers, J; Müller, R; Nelle, M; Schütz, N; Stoffel, L; van Lingen, RA; Zimmermann, L, 2009) |
| "Appreciation of pain is subject to the level of CNS lesions because during severe disorders behavioral reaction to pain is certainly reduced." | ( Gadzhieva, NN, 2009) |
| "Moderate to severe pain is commonly experienced by cancer and non-cancer patients." | ( Canneti, A; De Polo, C; Fabrizio Sabato, A; Gatti, A; Gubernari, M; Luzi, M; Mammucari, M; Occhioni, R; Reale, C, 2009) |
| "Multimodal pain is comprised of nociceptive/inflammatory and neuropathic components." | ( Bertini, L; Carucci, A; Gatti, A; Mammucari, M; Occhioni, R; Sabato, AF, 2009) |
| "Although pain is the major stumbling block deterring patients and physicians from choosing this treatment option, it is not the only one." | ( Benohanian, A, 2009) |
| "Pain is the most frequent functional aspect found with cancers." | ( Adoubi, I; Coulibaly, JD; Echimane, KA; Oseni, A; Touré, M, 2009) |
| "Neuropathic pain is often difficult to treat due to a complex pathophysiology." | ( Baron, R; Binder, A; Leijon, G; Mayoral, V; Serpell, M; Steigerwald, I, 2009) |
| "Under-treatment of pain is frequently reported, especially among seniors, with chronic non-cancer pain most likely to be under-treated." | ( Carrie, AG; Grymonpre, RE; Metge, CJ; Sadowski, CA; St John, P, 2009) |
| "Neuropathic pain is still an under-diagnosed and undertreated problem in third world countries." | ( Chatterjee, A; Choudhary, AH; Jain, PN; Sareen, R, 2009) |
| "Pain is frequent and often severe among women with HIV requiring medical management." | ( Anastos, K; Heikes, B; Karim, R; Richardson, JL; Weber, K; Young, M, 2009) |
| "The expectation of pain is created through the use of mild electric shocks to the top of the foot." | ( Berns, GS; Capra, CM; Moore, S; Noussair, C, 2008) |
| "Pain is a frequent complaint of hemodialysis (HD) patients, yet information regarding its causes and frequency is relatively scarce." | ( Bernheim, J; Golan, E; Haggiag, I; Os, P, 2009) |
| "Pain, is a major symptom which often accompanies cancer." | ( Baba-Hamed, N; Chouahnia, K; Des Guetz, G; Luu, M, 2009) |
| "Because persistent pain is frequently associated with psychological and emotional dysfunction, studies of the neural circuits and the molecular mechanisms involved in the affective component of pain may have considerable clinical importance in the treatment of chronic pain." | ( Minami, M, 2009) |
| "Pain is a common cause of disability in osteoarthritis." | ( Bennett, RM; Chappell, AS; Collins, H; Iyengar, S; Li, LC; Liu-Seifert, H; Ossanna, MJ; Skljarevski, V, 2009) |
| "Oesophageal pain is one of the most common reasons for physician consultation and/or seeking medication." | ( Blackshaw, LA; Page, AJ, 2009) |
| "Itch and pain are two distinct sensations." | ( Chen, ZF; Liu, XY; Meng, XL; Sun, YG; Yin, J; Zhao, ZQ, 2009) |
| "The way the pain is induced, assessed and summarized is very important for the sensitivity of the pain models." | ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Olesen, AE; Staahl, C, 2009) |
| "Although pain is a common sensation, it encompasses multiple neurobiologic components, of which NO is only one." | ( Gordh, T; Miclescu, A, 2009) |
| "Knee pain is predominant among osteoarthritis (OA) patients, but the mechanism is poorly understood." | ( Higashi, M; Moriya, H; Nakagawa, K; Ogino, S; Sasho, T; Suzuki, M; Takahashi, K; Yamaguchi, S, 2009) |
| "Pain is a common patient complaint during dermal filler injections." | ( Bank, DE; Boyd, CM; Gold, MH; Murphy, DK; Thomas, JA; Weinkle, SH, 2009) |
| "Pain is one of the most common symptoms in cancer patients." | ( Davis, MP; Lagman, RL; Lasheen, W; Shaheen, PE; Walsh, D, 2009) |
| "Chronic pain is a major clinical problem and opiates are often the only treatment, but they cause significant problems ranging from sedation to deadly respiratory depression." | ( Evans, MS; Jeffry, JA; Parihar, A; Premkumar, LS; Sikand, P; Yu, SQ, 2009) |
| "The presence of leg pain is an independent predictor of a patient's choice for operative over nonoperative care." | ( Berven, S; Bridwell, K; Fu, KM; Glassman, S; Hamill, C; Horton, W; Ondra, S; Schwab, F; Shaffrey, CI; Shainline, M; Smith, JS, 2009) |
| "Pain is known to be processed by a complex neural network (neuromatrix) in the brain." | ( Chen, J; Chen, XF; He, XS; He, Y; Li, H; Liu, MG; Wang, DD; Wang, Y; Yuan, DL; Zhang, FK; Zhao, XY, 2009) |
| "Cancer pain is a referent for disease status and has existential meaning, with the introduction of morphine becoming a metaphor for impending death." | ( Flemming, K, 2010) |
| "Pain is one of the most common reasons for admission to hospital for patients suffering from AIDS." | ( Evers, S; Hahn, K; Husstedt, IW; Kästner, F; Reichelt, D, 2009) |
| "Chronic neuropathic pain is underrecognized and undertreated, yet primary care physicians are uniquely placed on the frontlines of patient management, where they can play a pivotal role in treatment and prevention through diagnosis, therapy, follow-up, and referral." | ( Backonja, MM; Baron, R; Bennett, MI; Bouhassira, D; Cruccu, G; Haanpää, ML; Hansson, PT; Jensen, TS; Kauppila, T; Rice, AS; Smith, BH; Treede, RD, 2009) |
| "Cancer pain is one kind of the most common and severe kinds of chronic pain." | ( Gao, Q; Gu, X; Jin, Y; Ma, Z; Mei, F; Wang, J; Xia, X; Zhang, J; Zhou, X, 2010) |
| "Pain is a major issue after burns even when large doses of opioids are prescribed." | ( Berger, MM; Chiolero, RL; Davadant, M; Koch, N; Maravic, P; Marin, C; Pinget, C; Raffoul, W; Wasserfallen, JB, 2010) |
| "Pain is a complex experience involving extensive interactions between brain and spinal cord processes." | ( Arsenault, M; Piché, M; Rainville, P, 2009) |
| "Intensive pain is difficult to control with standard analgesics." | ( Aleksić-Shihabi, A; Buca, A; Jukić, I; Titlić, M; Tonkić, A, 2009) |
| "Pain is a major symptom in 70% of patients with advanced cancer." | ( Dale, O; Doehring, A; Klepstad, P; Lötsch, J, 2010) |
| "Neuropathic pain is usually persistent and there is no effective treatment." | ( Gao, Y; Li, G; Li, X; Lin, J; Linag, S; Liu, H; Liu, S; Xu, C; Zhang, A; Zhang, Y; Zhong, X, 2010) |
| "(1) Intermittent pain is a major problem in patients with cancer, (2) NBP is a common but under-recognized form of cancer pain, (3) NBP is less defined and controlled than BP, (4) incident NBP accounts for 40% of all incident cancer pain, and (5) variable IP definitions and classifications make comparisons between studies difficult." | ( Davis, M; Lasheen, W; Sarhill, N; Walsh, D, 2010) |
| "Neuropathic pain is regarded as one of the main causes of cancer pain refractory to standard opioid therapy in palliative care." | ( Shimoyama, N; Takahashi, H, 2010) |
| "Neuropathic pain is induced by injury or disease of the nervous system." | ( An, JX; Chu, GY; Guo, XY; He, HX; Tang, Y; Yu, CP, 2009) |
| "Pain is frequently reported and often undertreated in the elderly population." | ( Mort, JR; Schroeder, SD, 2009) |
| "Neuropathic pain is a common problem in clinical practice, affecting patients physically, emotionally, financially, and socially." | ( Moradimehr, A; Shah, TH, 2010) |
| "Neuropathic pain is relatively uncommon in children." | ( Dworkin, RH; Krane, EJ; LeBel, AA; Treede, RD; Walco, GA, 2010) |
| "Pain is among the most frequently reported, bothersome, and disabling symptoms described by patients with rheumatoid arthritis (RA), and the experience of pain is partially shaped by catastrophizing, a set of cognitive and emotional pain-related processes." | ( Bathon, J; Bingham, CO; Campbell, C; Edwards, RR; Giles, J; Haythornthwaite, JA, 2010) |
| "Pain is historically considered a cardinal sign of acute inflammation and a predominant symptom of IOIS." | ( Boothe, KH; Eckermann, DR; Musick, AN; Slagle, AM; Slagle, WS, 2010) |
| "Perineal pain is a common but poorly studied adverse outcome following childbirth." | ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2010) |
| "However, pain is often inadequately managed in elderly people, which undermines quality of life." | ( Finco, G; Lussier, D; Richarz, U, 2010) |
| "Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS)." | ( Kivell, B; Prisinzano, TE, 2010) |
| "Pain is a complex subjective phenomenon that so far cannot be objectively quantified by any standardized procedure." | ( Auffermann, W; Lorenz, J, 2010) |
| "Foot pain is highly prevalent and associated with foot deformity and leg and low back pain." | ( Lundbye-Christensen, S; Mølgaard, C; Simonsen, O, 2010) |
| "Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects." | ( Berta, T; Ji, RR; Liu, T; Park, JY; Serhan, CN; Xu, ZZ; Yang, R; Zhang, L, 2010) |
| "Visceral pain is a significant issue for patients, and the importance of treating pain is underestimated." | ( Bruno, L; Gottardi, M; Liguori, S; Micheletto, G, 2010) |
| "Neuropathic pain is a recognized type of pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue." | ( Cahill, CM; Leung, L, 2010) |
| "Cancer pain is debilitating and has multidimensional consequences." | ( Cheema, B; Davis, MP; Estfan, B; Lagman, RL; Legrand, SB; Riaz, M; Shaheen, PE; Walsh, D, 2010) |
| "Breakthrough pain is defined as transitory flares of pain." | ( Davis, MP, 2010) |
| "Chronic noncancer pain is highly prevalent with associated negative effects on function and quality of life of the individuals involved." | ( Benyamin, R; Datta, S; Manchikanti, L; Smith, H; Vallejo, R, 2010) |
| "Neuropathic pain is difficult to treat." | ( Alkhalaf, A; Bilo, HJ; Kleefstra, N; Mijnhout, GS, 2010) |
| "Pain is a complex and subjective experience that involves not only the transduction of noxious stimuli by nociceptive fibers, but also the cognitive and emotional processing by the brain." | ( Chen, T; Chen, Y; Dang, Y; Lai, J; Xu, M; Yan, C; Zhu, J, 2010) |
| "Pain is the most frequent complication of this haemoglobin disorder." | ( Ahmedzai, SH; Wright, J, 2010) |
| "Neuropathic pain is a highly debilitating chronic pain following damage to peripheral sensory neurons and is often resistant to all treatments currently available, including opioids." | ( Hasegawa, S; Inoue, K; Ishii, S; Kohro, Y; Shimizu, T; Shiratori, M; Tsuda, M, 2010) |
| "The pain is often not completely relieved despite the use of medication." | ( Ortiz, MI, 2010) |
| "Chronic pain is often equated with chronic stress yet the relationship between chronic pain and hypothalamic-pituitary-adrenal (HPA) axis activity is poorly understood." | ( da Silva, L; Jessop, DS; Keogh, E; Osborn, M; Turner-Cobb, JM, 2010) |
| "Neuropathic pain is a common problem following spinal cord injury (SCI)." | ( Ahmed, MM; Hasbargen, T; Kahle, KT; Li, L; Miranpuri, G; Resnick, D; Sun, D, 2010) |
| "Pain is one of the major adverse effects during and after the treatment." | ( Denk, K; Enk, A; Gholam, P; Hartmann, M; Sehr, T, 2010) |
| "Neuropathic pain is a major health issue and is frequently accompanied by allodynia (painful sensations in response to normally non-painful stimulations), and unpleasant paresthesia/dysesthesia, pointing to alterations in sensory pathways normally dedicated to the processing of non-nociceptive information." | ( Bebber, D; Decosterd, I; Gosselin, RD, 2010) |
| "Chronic pain is common and can be devastating to the patient and challenging to the health care provider." | ( Elhwairis, H; Reznich, CB, 2010) |
| "Pain is a significant problem in patients with cancer." | ( Brant, JM, 2010) |
| "Existential pain is more typical of a person uninterested in a transcendent context and may be more challenging to address in the health care context." | ( Balducci, L, 2010) |
| "Pain is a rare symptom in epileptic seizures." | ( Alving, J; Andersen, N; Atkins, MD; Beniczky, S; Dahl, M; Jovanovic, M; Wolf, P, 2011) |
| "Pain is the most common reason for seeking health care in the Western world and is a contributing factor in up to 80% of all emergency department (ED) visits." | ( Ali, S; Beno, S; Drendel, AL; Kircher, J, 2010) |
| "Chronic pain is a serious public health problem and is treated by diverse health care providers." | ( Breuer, B; Cruciani, R; Portenoy, RK, 2010) |
| "Alleviating pain is of high importance for children undergoing chemotherapy." | ( Gerr, H; Grigull, L; Hoy, L; Klein, C; Leonhardt, J; Linderkamp, C; Lüllmann, B; Metzelder, M, 2010) |
| "Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied." | ( Bushnell, MC; Mak, E; Nandhagopal, R; Schulzer, M; Stoessl, AJ; Troiano, AR, 2010) |
| "Pain is often underrecognized and undertreated among older people." | ( Bell, JS; Hartikainen, S; Lihavainen, K; Pokela, N; Sulkava, R, 2010) |
| "Pain is a frequent symptom in clinical practice." | ( Benvenuti-Falger, U; Böhmdorfer, B; Dovjak, P; Gosch, M; Iglseder, B; Lechleitner, M; Otto, R; Roller, RE; Sommeregger, U, 2010) |
| "Pain is a prominent symptom in radiotherapy-induced oral mucositis (OM)." | ( Larsson, B; Ling, IS, 2011) |
| "As pain is still undertreated in pediatric anesthesia, opioids should be used generously but well-considered." | ( Becke, K, 2010) |
| "Pain is a common feature of laminitic pathology and its management is an important component of the treatment regime for this disease." | ( Belknap, JK; Black, SJ; Loftus, JP; Williams, JM, 2010) |
| "Chronic pain is a major problem in primary care." | ( Friessem, CH; Willweber-Strumpf, A; Zenz, MW, 2010) |
| "Pain is a prevalent symptom affecting as many as 50% of community-dwelling older adults." | ( Javier, N; Tomas, M, 2010) |
| "Pain is one of the most prevalent conditions, which limits productivity and diminishes quality of life." | ( Brüning, CA; Nogueira, CW; Prigol, M; Roehrs, JA; Zeni, G, 2010) |
| "Pain is a common, often undertreated problem among patients with palliative needs." | ( Asch, SM; Cohen, A; Goebel, J; Hagenmeier, E; Lanto, A; Lorenz, KA; Meredith, LS; Rubenstein, LV; Sherbourne, CD; Shugarman, LR; Wen, L, 2010) |
| "Even when injection pain is reduced, the use of a premedication regimen clearly has additional value with respect to the patients' experience." | ( Adam, S; Dedic, A; Gommers, D; Van Bommel, J, 2010) |
| "Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment." | ( Dasilva, D; Freedman, SD; Fregni, F; Lenkinski, RE; Pascual-Leone, A; Potvin, K; Wang, X, 2011) |
| "Chronic pain is modeled experimentally through a variety of manipulations of sensory nerves including cutting, crushing, resection, and ligation." | ( Miller, DB; O'Callaghan, JP, 2010) |
| "Pain is an integral part of the defense mechanisms required for survival." | ( Hamet, P; Tremblay, J, 2010) |
| "Inflammatory pain is triggered by activation of pathways leading to the release of mediators such as bradykinin, prostaglandins, interleukins, ATP, growth factors and protons that sensitize peripheral nociceptors." | ( Cato, MJ; Cook, SP; Garsky, VM; Kane, S; Karczewski, J; Leitl, MD; Liang, A; Spencer, RH; Urban, MO, 2010) |
| "Cancer pain is unfortunately very prevalent, with opioids the mainstay of treatment." | ( Trescot, AM, 2010) |
| "Enhanced somatic pains are accompanied by mechanical hyperalgesia and allodynia in FM patients as compared with healthy controls." | ( Staud, R, 2010) |
| "Funicular leg pain is a rare presentation of cervical cord compression." | ( Chan, CK; Cho, JY; Choi, WC; Lee, HY; Lee, SH, 2011) |
| "The perception of pain is subject to powerful influences." | ( Tracey, I, 2010) |
| "Pain is a multidimensional sensory phenomenon that has evolved as a protective method for maintaining homeostasis and facilitating tissue repair." | ( Muir, WW, 2010) |
| "Chronic pain is often a symptom after local anaesthetic-induced nerve injury." | ( Adey-Viscuso, D; Meechan, JG; Renton, T; Yilmaz, Z, 2010) |
| "Chronic pain is not very common in patients who have had their inguinal hernias repaired with titanium-covered polypropylene mesh." | ( Schardey, H; Schopf, S; von Ahnen, M; von Ahnen, T, 2011) |
| " Self-management of pain is a critical component of arthritis care; however, limited mobility can restrict access to resources." | ( Ainscough, JL; Charity, S; Pujol, LA; Trudeau, KJ, 2010) |
| "Growing pains are common among children aged 2-12 years and are characterized by recurrent, self-limited, bilateral lower extremity pain, mostly in the afternoon and evening, and even at night, in an otherwise healthy child." | ( Harel, L, 2010) |
| "Pain is a complex biological phenomenon that encompasses intricate neurophysiological, behavioural, psychosocial and affective components." | ( McDougall, JJ, 2011) |
| "Long-term pain is a debilitating condition that is costly to treat and has a significant impact on patient quality of life." | ( Ahlbeck, K, 2011) |
| "Bone-cancer pain is a common and refractory cancer pain." | ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| "Pain is one of the most common reasons that patients seek treatment from health care professionals, often their primary care providers." | ( Lewis, ET; Trafton, JA, 2011) |
| "Breakthrough pain is a transient exacerbation of pain that occurs either spontaneously or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain." | ( Zeppetella, G, 2011) |
| "Although pain is common among advanced cancer patients, it can be controlled in a large proportion of patients." | ( Azoulay, D; Cialic, R; Jacobs, JM; Mor, EE; Stessman, J, 2011) |
| "Chronic pain is a common and debilitating symptom experienced in the context of numerous other physical and emotional symptoms by many patients with chronic kidney disease (CKD)." | ( Davison, JS; Davison, SN, 2011) |
| "Pain is a complex subjective experience that is shaped by numerous contextual factors." | ( Haggard, P; Kammers, MP; Longo, MR; Mancini, F, 2011) |
| "Central neuropathic pain is a frequent challenging complication after spinal cord injury (SCI), and specific therapeutic approaches remain elusive." | ( Held-Feindt, J; Knerlich-Lukoschus, F; Lucius, R; Mehdorn, HM; von der Ropp-Brenner, B, 2011) |
| "However, PDT pain is multifactorial and choice of photosensitiser is probably not a major pain determining factor." | ( Attili, SK; Dawe, R; Ibbotson, S, 2011) |
| "Pain is one of the most common reasons for seeking medical care and the frequency of prescription of opioid analgesics by both primary care physicians and specialists has increased." | ( Asensio-Samper, JM; De Andrés-Ibáñez, J; Fabregat-Cid, G; López-Alarcón, MD; Villanueva-Pérez, V, 2011) |
| "Pain is a major health concern even though numerous analgesic agents are available." | ( Brosnan, R; Hammock, BD; Hegedus, C; Inceoglu, B; Jinks, SL; Morisseau, C; Rose, T; Schebb, NH; Ulu, A; Wagner, K, 2011) |
| "Local forearm/wrist pain is relatively frequent in this setting, and is not significantly prevented by intra-arterial lidocaine." | ( Agostoni, P; Biondi-Zoccai, GG; Moretti, C; Omedè, P; Romagnoli, E; Sangiorgi, G; Sciuto, F; Sheiban, I, 2011) |
| "Pain is prevalent among people who have cancer, and is one of the most feared and burdensome symptoms." | ( Daher, M, 2011) |
| "Back and knee pain is a widespread health problem and a serious threat to the quality of life (QOL) in middle-aged and older adults, as it frequently accompanies osteoporosis and osteoarthritis." | ( Fujii, Y; Fujita, T; Miyauchi, A; Nakajima, M; Ohue, M; Takagi, Y, 2011) |
| "Pain is one of the major nonmotor symptoms of Parkinson's disease." | ( Bartolo, M; Buscone, S; Martignoni, E; Pacchetti, C; Perrotta, A; Pierelli, F; Sandrini, G; Serrao, M; Tassorelli, C; Tinazzi, M; Zangaglia, R, 2011) |
| "Untreated pain is a major public health problem, but concerns about opioid misuse remain." | ( Buchbinder, R; Howes, F; Winzenberg, TB, 2011) |
| "Pain is among the most common reasons patients seek medical attention, and the care of patients with pain is a significant problem in the United States." | ( McCarberg, BH, 2011) |
| "Cancer pain is generally treated with pharmacological measures, relying on using opioids alone or in combination with adjuvant analgesics." | ( Leppert, W, 2011) |
| "Pain is a major issue for patients with severe burn." | ( Cleland, H; Costello, V; Ferraro, F; Konstantatos, A; Paul, E; Spinks, A; Wasiak, J, 2011) |
| "Pain is both a sensation and an emotional experience, and thus it has been defined as total pain." | ( Aruga, E, 2011) |
| "Chronic pain is a sensory experience that produces suffering and functional impairment and is the result of both sensory input as well as secondary adaptation of the nervous system." | ( Clark, MR; Treisman, GJ, 2011) |
| "Chronic pain is prevalent in patients with major depressive disorder (MDD)." | ( Liu, X; Mullins, CD; Wang, J, 2011) |
| "Pain is a common presenting complaint and there is considerable debate regarding the best practice for analgesia in the pre-hospital environment for trauma patients with severe pain." | ( Bernard, S; Cameron, P; Jennings, PA, 2011) |
| "Cancer pain is a distressing result of disease, both primary and metastatic, as well as complications caused by cancer treatment." | ( Cope, DK; Zhao, Z, 2011) |
| "Depression and pain are often diagnosed in the same patients." | ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| "Neuropathic pain is a compilation of somatosensory, cognitive and emotional alterations developing following nerve injuries." | ( Machelska, H, 2011) |
| "Pain is the predominant medical presentation to hospitalists for patients with sickle cell disease (SCD)." | ( Hassell, KL; Jordan, LB; Smith, WR, 2011) |
| "Rib fracture pain is notoriously difficult to manage." | ( Mayberry, JC; Peck, EG; Schreiber, MA; Zink, KA, 2011) |
| "Pain is the leading cause of emergency department visits, hospitalizations, and daily suffering in individuals with sickle cell disease (SCD)." | ( Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ, 2011) |
| "Pain is brought into play by a system which detects and transmits messages signaling pain." | ( de la Brière, A, 2011) |
| "The treatment of pain is an essential component of the clinical and ethical care of infants." | ( Bittle, M; Chang, K; Deluca, J; Hatfield, LA; Polomano, RC, 2011) |
| "Pain is one of the major adverse effects." | ( Denk, K; Enk, A; Gholam, P; Weberschock, T, 2011) |
| "Comparing pain is done in daily life and involves short-term memorizing and attention focusing." | ( Anti, S; Deichmann, R; Felden, L; Lötsch, J; Martin, T; Nöth, U; Oertel, BG; Preibisch, C; Walter, C, 2012) |
| "Evaluation of pain is a critical issue in human pathologies but also in animal experimentation." | ( Charlet, A; Poisbeau, P; Rodeau, JL, 2011) |
| "Pain is an unpleasant sensory perception warning of actual or impending tissue damage." | ( Neil, MJ, 2011) |
| "After the pain is resolved and the examination shows improvement, patients may gradually increase their level of activity." | ( Kapil, N; Patel, DS; Roth, M, 2011) |
| "Neuropathic pain is therefore initiated by HCN2-driven action potential firing in Na(V)1." | ( Berrocoso, EM; Chen, L; Emery, EC; McNaughton, PA; Young, GT, 2011) |
| "Cancer pain is common, occurring in up to 60% of patients and opioid conversion may be required for effective pain management." | ( Kutner, JS; Linnebur, SA; O'Bryant, CL; Yamashita, TE, 2008) |
| "Pain is common among opioid-dependent patients, yet pharmacologic strategies are limited." | ( Anderson, BJ; Herman, DS; Kettavong, M; Stein, MD; Tsui, JI, 2011) |
| "Pain is a public health problem whose management shows a series of deficiencies." | ( Barbosa, CG; Bianchini, KC; Kulkamp, IC, 2008) |
| "Chronic pain is a common neurological disease involving lasting, multifaceted maladaptations ranging from gene modulation to synaptic dysfunction and emotional disorders." | ( Bie, B; Cai, YQ; Pan, ZZ; Zhang, Z; Zou, F, 2011) |
| "Pain is characterized by its multi-dimensional nature, explaining in part why the pharmacokinetic/pharmacodynamic (PK/PD) relationships are not straightforward for analgesics." | ( Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K, 2012) |
| "Pain is still a primary concern in the emergency department." | ( Eslami, V; Farahmand, S; Hajiseyedjavady, H; Saeedi, M; Shahsavarinia, K, 2012) |
| "Pain is among the most frequent and distressing symptoms in terminally-ill cancer and, to date, many patients still experience uncontrolled pain." | ( Bordin, F; D'Addario, ME; Di Miele, D; Fava, A; Ferraccioli, A; Lanzetta, G; Ranucci, A; Rozzi, A; Salerno, M; Scirocchi, R; Terzoli, L, 2011) |
| "Cancer pain is one of the most severe types of chronic pain, and the most common cancer pain is bone cancer pain." | ( Duan, KZ; Mei, YA; Xu, Q; Zhang, XM; Zhang, YQ; Zhao, ZQ, 2012) |
| "The causes of back pain are very different and numerous, but mostly are due to vertebral, mechanical etiology, and rarely because of non vertebral, visceral etiology." | ( Kovac, I, 2011) |
| "Insomnia and limb pain are common problems in dialysis patients." | ( Malaki, M; Moazemi, S; Mortazavi, FS; Shoaran, M, 2012) |
| "Hand and wrist pain is a diagnostic challenge for hand surgeons and radiologists due to the complex anatomy of the involved small structures." | ( Bürkert, A; Huellner, MW; Hug, U; Schleich, FS; Schürch, M; Strobel, K; Veit-Haibach, P; von Wartburg, U, 2012) |
| "Pain is harmful to newborn infants." | ( Huber, JM; Pasek, TA, 2012) |
| "Pain is a global health challenge." | ( Li, JX; Zhang, Y, 2012) |
| "Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraints." | ( Cherubino, P; Fornasari, D; Labianca, R; Sarzi-Puttini, P; Vellucci, R; Zuccaro, SM, 2012) |
| "Whether ongoing pain is present in this model is unknown." | ( Brion, T; Davis, P; Dussor, GO; King, T; Liu, P; Okun, A; Ossipov, MH; Porreca, F; Remeniuk, B; Ren, J; Xie, J, 2012) |
| "Itch and pain are common symptoms in skin disease." | ( Evers, AW; Kraaimaat, FW; Kroeze, S; van de Kerkhof, PC; van Laarhoven, AI; van Riel, PL; Walker, AL; Wilder-Smith, OH, 2012) |
| "Cancer pain is one of the most severe chronic pains." | ( Gu, X; Liu, Y; Ma, Z; Zhang, J; Zhang, R; Zheng, Y, 2012) |
| "Bone cancer pain is difficult to treat and has a strong impact on the quality of life of patients." | ( Guo, F; Hang, LH; Ji, FH; Shao, DH; Wang, LN; Wang, XY; Xu, QN; Yang, JP; Yin, W; Zuo, JL, 2012) |
| "Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician's fear of the adverse effect of analgesia and lack of anesthetist present." | ( Guangyi, W; Guoxia, M; Hongtai, T; Jianqiang, Y; Jijun, Z; Lu, T; Ming, Y; Shichu, X; Wanfang, Z; Wannian, Z; Wen, N; Wenjun, H; Xiaoyan, H; Xiuqiang, M; Xiuying, D; Yinsheng, W; Yuxiang, L; Zhaofan, X, 2012) |
| "The degree of pain is highly variable and adults reports more pain than children." | ( Chapurlat, RD; Gensburger, D; Ghilardi, JR; Jimenez-Andrade, JM; Kelly, M; Mantyh, P, 2012) |
| "Severe pain is defined as rated seven or greater on a 0 to 10 age-appropriate numeric pain scale or equivalent." | ( an Fhailí, S; Barrett, MJ; Cronin, J; Grant, T; Hayden, J; McCoy, S; McMahon, C; Murphy, A; O'Sullivan, R; Wakai, A; Walsh, S, 2012) |
| "Pain is a major issue for patients suffering from many different types of wounds, in particular those with burn injuries." | ( Cleland, H; Danilla, S; Mahar, P; McGuinness, SK; Spinks, A; Wasiak, J, 2012) |
| "Because pain is a very common condition in children, such as after musculoskeletal injuries, many parents ask whether they can alternate over-the-counter analgesics to treat their children's pain." | ( Goldman, RD; Smith, C, 2012) |
| "Pain is associated with skin injections." | ( Al Dabbagh, Z; Al-Aboosi, M; Al-Qarqaz, F; Al-shiyab, D, 2012) |
| "Pain is associated with inhibition of muscle activity in the (painful) agonist and its non-painful antagonists and synergists, especially at higher intensities of muscle contraction." | ( Bank, PJ; Beek, PJ; Marinus, J; Peper, CE; van Hilten, JJ, 2013) |
| "Pain is undertreated and more complex to manage in these patients for a number of reasons, including complex anti-retroviral drug regimens, higher risks of side effects, and higher rates of comorbid psychiatric illness and substance abuse." | ( Krashin, DL; Merrill, JO; Trescot, AM, 2012) |
| "Bone cancer pain is chronic and often difficult to control with opioids." | ( Hasegawa, M; Kanbara, T; Kato, A; Minami, K; Nakamura, A; Narita, M; Nishiyori, A; Suzuki, T; Tomii, T, 2013) |
| "Pain is a common and significant feature of burn injury." | ( Cleland, H; Mahar, PD; Menezes, H; Paul, E; Spinks, AB; Wasiak, J, 2014) |
| "Fear of dental pain is a major barrier to children needing dental care." | ( Anand, P; Ashley, PF; Behbehani, A; Moles, DR; Parekh, S, 2012) |
| "Physical pain is common among individuals seeking treatment for opioid dependence." | ( Cunningham, CO; Fox, AD; Giovanniello, A; Ning, Y; Sohler, NL; Starrels, JL, 2012) |
| "MS-related pain is difficult to treat, since very little is known about the mechanisms underlying its development." | ( Kuner, R; Kurejova, M; Linker, RA; Lu, J; Tappe-Theodor, A; Wirotanseng, LN, 2012) |
| "Arthritis pain is a complex phenomenon involving intricate neurophysiological processing at all levels of the pain pathway." | ( Linton, P; McDougall, JJ, 2012) |
| "Pain is a common symptom in Parkinson's disease (PD) and accounts for substantial morbidity in up to 80 % of patients." | ( Ford, B; Sophie, M, 2012) |
| "Pain is undertreated." | ( Authier, N; Courty, P, 2012) |
| "Relief of pain is rewarding." | ( Ci, S; Eyde, N; Fields, HL; King, T; Navratilova, E; Okun, A; Ossipov, MH; Porreca, F; Qu, C; Xie, JY, 2012) |
| "Pain is present more often in younger individuals and in females and, according to the visual analogue scale (VAS), the intensity of pain is relatively high." | ( Borg, K; Werhagen, L, 2013) |
| "Pain is common in patients with post-polio syndrome." | ( Borg, K; Werhagen, L, 2013) |
| "Pain is a common symptom in multiple sclerosis (MS) and has recently been estimated to be experienced by up to 75 % of patients." | ( Messmer Uccelli, M; Solaro, C; Trabucco, E, 2013) |
| "Propofol injection pain is a frequent and a well-known complaint distressing for the patients." | ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "Pain is a negative emotional experience that is modulated by a variety of psychological factors through different inhibitory systems." | ( Arduino, C; Benedetti, F; Blanchard, C; Thoen, W; Vighetti, S, 2013) |
| "Pain is not a symptom generally associated with thalassaemia." | ( Carson, S; Coates, T; Dinu, B; Eile, J; Gerstenberger, E; Green, S; Haines, D; Martin, M; Mendoza, T; Oliveros, O; Schilling, L; Trachtenberg, F; Vichinsky, E, 2013) |
| "Pain is associated with stimulation of some behaviors (eg, withdrawal reflexes) but depression of many other behaviors (eg, feeding, locomotion, positively reinforced operant behavior)." | ( Carroll, FI; Negus, SS; Rosenberg, MB, 2013) |
| "FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety." | ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013) |
| "Chronic widespread pain is a hallmark of fibromyalgia (FM)." | ( Chang, Y; Decety, J; Do, Y; Han, SW; Kim, SH; Kim, SK; Lee, HJ; Lee, SJ; Nam, EJ; Seo, J; Song, HJ, 2013) |
| "Perineal pain is a common but poorly studied adverse outcome following childbirth." | ( Abalos, E; Chou, D; Gülmezoglu, AM; Gyte, GM, 2013) |
| "Severe pain is associated with a decreased quality of life in patients with cancer." | ( Bennett, MI; Ke, W; Lihua, P; Su, M; Zejun, Z, 2013) |
| "Inflammatory pain is the result of a process that depends on neutrophil migration, cytokines and prostanoids release and oxidative stress." | ( Casagrande, R; Hohmann, MS; Mizokami, SS; Navarro, SA; Serafim, KG; Verri, WA, 2013) |
| "Chronic pain is usually treated with pharmacological measures using opioids alone or in combination with adjuvant analgesics that play an important role in the treatment of pain not fully responsive to opioids administered alone, especially in neuropathic, bone and visceral colicky pain." | ( Krajnik, M; Leppert, W; Wordliczek, J, 2013) |
| "Pain is the most common symptom reported in both the general population and the general medical setting." | ( Huang, X; Ji, JL; Li, C; Luo, YL; Wang, B, 2013) |
| "Pain is common in patients with liver disease, difficult to treat, and poorly understood." | ( Bielefeldt, K; Rogal, SS; Szigethy, E; Winger, D, 2013) |
| "As pain is the main problem associated with endometriosis, LNG-IUS placement is beneficial at the time of surgery when it is diagnosed." | ( Hertweck, P; LaJoie, AS; Loveless, M; Yoost, J, 2013) |
| "Pain is a complex experience composed of sensory and affective components." | ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| "Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment." | ( Atlas, LY; Kross, E; Lindquist, MA; Roy, M; Wager, TD; Woo, CW, 2013) |
| "Back pain is generally experienced to a high extent by patients scheduled for spinal stenosis surgery." | ( Jönsson, B; Sigmundsson, FG; Strömqvist, B, 2013) |
| "Pain is a frequently observed non-motor symptom of patients with Parkinson's disease." | ( Baumann, CR; Baumann-Vogel, H; Imbach, LL; Sürücü, O; Uhl, M, 2013) |
| "Itch and pain are closely related but distinct sensations." | ( Ji, RR; Liu, T, 2013) |
| "Pain is a problem that often has to be addressed in the prehospital setting." | ( Johansson, J; Nordgren, M; Sandström, E; Sjöberg, F; Sjöberg, J; Zetterström, H, 2013) |
| "Pain is the single most common reason why patients seek medical care." | ( Balding, L, 2013) |
| "Pain is common during colonic insufflation required for CT colonography." | ( Boellaard, TN; Eberl, S; Hollmann, MW; Kavaliauskiene, G; Peringa, J; Runge, JH; Schouten, LJ; Stoker, J; Tielbeek, JA; van der Paardt, MP, 2013) |
| "Pain is a ubiquitous yet highly variable experience." | ( Aziz, Q; Brammer, M; Coen, SJ; Droney, J; Farmer, AD; Furlong, PL; Giampietro, VP; Jafari, J; Kano, M; Kishor, J; Knowles, CH; Kumari, V; Lightman, SL; Paine, PA; Riley, J; Rossiter, HE; Shwahdi, M; Williams, SCR; Worthen, SF, 2013) |
| "Pain is experienced by the overwhelming majority of patients during their intensive care unit stay, but it remains an underappreciated problem." | ( Gélinas, C; Hallman, M; Herr, DL; Joffe, AM; Puntillo, K, 2013) |
| "Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it." | ( Longo, G; Osikowicz, M; Ribeiro-da-Silva, A, 2013) |
| "Pain is the major drawback of photodynamic therapy (PDT), an otherwise effective treatment for actinic keratoses (AKs)." | ( Buinauskaite, E; Buinauskiene, J; Valiukeviciene, S; Zalinkevicius, R, 2013) |
| "Chronic pain is thought to be partly caused by a loss of GABAergic inhibition and resultant neuronal hyperactivation in the central pain-modulating system, but the underlying mechanisms for pain-modulating neurons in the brain are unclear." | ( Lu, YG; Pan, ZZ; Wang, W; Wang, X; Zhang, Z, 2013) |
| "Acute pain is one of the main causes of hospital admission in sickle cell disease, with variable intensity and unpredictable onset and duration." | ( Faris, AS; Kausalya, R; Tawfic, QA, 2014) |
| "Pain is the most frequent and distressing symptom in cancer patients." | ( Hosoya, M; Matoba, M; Morita, T; Shima, Y; Yamaguchi, T, 2013) |
| "Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED)." | ( Alesi, A; Antonini, EF; Cordischi, C; Franceschi, F; Giacobelli, D; Iacomini, P; Marsiliani, D; Zuccalà, G, 2013) |
| "Pain is a common symptom associated with cancer and its treatment." | ( Abernethy, AP; Anghelescu, DL; Benedetti, C; Buga, S; Cleeland, C; Deleon-Casasola, OA; Dwyer, M; Eilers, JG; Ferrell, B; Green, M; Janjan, NA; Kamdar, MM; Kumar, R; Levy, MH; Lynch, M; McDowell, RM; Moryl, N; Nesbit, SA; Paice, JA; Rabow, MW; Swarm, RA; Syrjala, KL; Urba, SG; Weinstein, SM, 2013) |
| "Pain is a common and often severe pathological feature of cancers in bone, and is a significant impediment to the maintenance of quality of life of patients living with bone metastases." | ( Seidlitz, EP; Singh, G; Ungard, RG, 2014) |
| "Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment." | ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014) |
| "The level of pain is a major determinant for the outcome of any treatment of these fractures regardless of its location." | ( Cisari, C; Frizzi, L; Gimigliano, F; Gimigliano, R; Iolascon, G; Moretti, A, 2013) |
| "Ischemic pain is complex and poorly understood." | ( Boezaart, AP; Kucera, TJ, 2014) |
| "Pain is relatively infrequent in SCD infants and young children and commonly managed at home." | ( Aertker, L; Brodecki, D; Coleman, C; Dampier, C; Ely, B; Hyslop, T; Kesler, K; Leiby, B; Sendecki, JA; Stuart, M, 2014) |
| "Leg pain is a very common complaint in clinical medicine which deserves thorough investigation." | ( Machetanz, J; Schellong, S; Stelzner, C; Unger, L; Wollina, U, 2013) |
| "Pain is one of the major symptoms of the osteoarthritis (OA)." | ( Belen'kiĭ, DA; Borisenko, OV, 2013) |
| "Acute postoperative pain is not associated with pupillary diameter or PLRA." | ( Guglielminotti, J; Kantor, E; Longrois, D; Montravers, P, 2014) |
| "Pain is a major side effect thereof, and it affects the treatment compliance and acceptance." | ( Barge, J; Glanzmann, T; Salomon, D; van den Bergh, H; Wagnières, G; Zellweger, M, 2013) |
| "Pain is a complex disorder with neurochemical and psychological components contributing to the severity, the persistence, and the difficulty in adequately treating the condition." | ( Bohn, LM; Raehal, KM, 2014) |
| "Chronic pain is frequently treated with our most potent analgesics, the opioids." | ( Sloan, P, 2014) |
| "Greater neonatal pain is associated with higher internalizing behaviours in very preterm infants at 18 months corrected age, but it is unknown whether this relationship persists to school age." | ( Grunau, RE; Ranger, M; Synnes, AR; Vinall, J, 2014) |
| "Pain is one of the most common and distressing elements of suffering related to cancer and cancer treatment." | ( Davis, MP; Fielding, F; Sanford, TM, 2013) |
| "Pain is a significant and alarming symptom of cancer seriously affecting the activity and quality of life of patients." | ( Heigl, P, 2014) |
| "Pain is a prevalent complaint." | ( Gharaei, H; Shadlou, H, 2014) |
| "Bone cancer pain is a major clinical problem and remains difficult to treat." | ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014) |
| "Inflammatory pain is based on stimulation and sensitization of peripheral endings of sensory neurons (nociceptors) by pronociceptive mediators." | ( Denis, CV; Geisslinger, G; Linke, B; Meyer dos Santos, S; Nieswandt, B; Pierre, S; Scholich, K; Stegner, D; Suo, J; Zhang, DD, 2014) |
| "Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus." | ( Gurtskaia, G; Nebieridze, M; Nozadze, I; Tsagareli, MG; Tsiklauri, N, 2014) |
| "Pain is a troublesome non-motor symptom of Parkinson's disease (PD)." | ( Boroojerdi, B; Chaudhuri, KR; Ghys, L; Kassubek, J; Moran, K; Surmann, E; Trenkwalder, C; Zesiewicz, T, 2014) |
| "Acute dental pain is a recognised precipitant of unintentional paracetamol overdose and in a small but significant number of cases this results in hepatotoxicity." | ( Byers, J; Marney, C; Nayyer, NV, 2014) |
| "Leg pain is associated with back pain in 25-65% of all cases and classified as somatic referred pain or radicular pain." | ( Briffa, KN; Hall, TM; Lüdtke, K; Mallwitz, J; Rolke, R; Schäfer, AG; Treede, RD, 2014) |
| "Inflammatory and pain are major areas for drug discovery." | ( Dai, D; Deng, X; Huang, W; Lin, H; Qian, H; Qiu, Q; Wang, J, 2015) |
| "Bone cancer pain is the most severe among cancer pain and is often resistant to current analgesics." | ( Dohi, T; Kanematsu, T; Kitayama, T; Morita, K; Motoyama, N; Shiraishi, S; Uezono, Y, 2014) |
| "Pain is experienced during both the biopsy and the marrow aspiration." | ( Bressel, M; Milner, A; Spruyt, O; Wein, S; Westerman, D, 2014) |
| "Skin reactions and pain are commonly reported side effects of radiation therapy (RT)." | ( Gewandter, JS; Heckler, CE; Morrow, GR; Ryan, JL; Walker, J, 2013) |
| "The assessment of pain is critical for the welfare of horses, in particular when pain is induced by common management procedures such as castration." | ( Canali, E; Dalla Costa, E; Leach, MC; Lebelt, D; Minero, M; Stucke, D, 2014) |
| "How to reduce pain is a fundamental clinical and experimental question." | ( Maravita, A; Romano, D, 2014) |
| "Bone pain is the most notorious adverse effect caused by G-CSFs." | ( Copeland, L; Li, Q; Romeo, C, 2015) |
| "Pain is the most common symptom in patients with advanced cancer and often persists despite treatment." | ( Gough, N; Linch, M; Miah, AB, 2014) |
| "Cancer pain is complex and an understanding of the type of pain, the biology of the particular cancer as well as patient factors must be considered." | ( Gough, N; Linch, M; Miah, AB, 2014) |
| "Chronic pain is a multidimensional experience that not only includes changes in nociception but also impairments in emotional and cognitive functions, not often taken into account in preclinical research." | ( Ardid, D; Etienne, M; Grégoire, S; Marchand, F; Wattiez, AS, 2014) |
| "Chronic pain is an important public health problem that negatively impacts quality of life of affected individuals and exacts an enormous socio-economic cost." | ( Morimura, K; Ossipov, MH; Porreca, F, 2014) |
| "Propofol injection pain is a common and unsolved anaesthesia problem." | ( Jia, Y; Lei, W; Shen, Y; Wu, Q; Zhang, N, 2014) |
| "Propofol injection pain is increased by contact with PVC infusion tubing as a result of an increase in aqueous propofol concentration caused by di(2-ethylhexyl) phthalate leaching into the lipid emulsion." | ( Jia, Y; Lei, W; Shen, Y; Wu, Q; Zhang, N, 2014) |
| "Pain is a multidimensional experience, which includes sensory, cognitive, and affective aspects." | ( Baumkötter, J; Heitmann, H; Ploner, M; Schulz, E; Tiemann, L, 2014) |
| "Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms." | ( Colvin, LA; Currie, GL; Fallon, MT; Macleod, MR; Sena, ES, 2014) |
| "Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido." | ( Binik, YM; Chan, L; Chen, M; Farmer, MA; Foxen-Craft, E; Leja, A; MacIntyre, LC; Mapplebeck, JC; Mogil, JS; Niaki, T; Pfaus, JG; Sukosd, M; Tabry, V; Topham, L, 2014) |
| "The management of pain is an essential aspect of comprehensive cancer care." | ( Ahmed, E; Portenoy, RK, 2014) |
| "Pain is common in advanced malignancy but also prevalent in other non-malignant life-limiting diseases such as advanced heart disease; end stage renal failure and multiple sclerosis." | ( Harris, DG, 2014) |
| "Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome." | ( Aarsland, D; Ballard, C; Corbett, A; Husebo, BS; Sandvik, RK; Seifert, R; Selbaek, G, 2014) |
| "Experimental pain is known to affect neuroplasticity of the motor cortex as well as motor performance, but less is known about neuroplasticity of somatosensory processing in the presence of pain." | ( Dancey, E; Murphy, B; Srbely, J; Yielder, P, 2014) |
| "Hand pain is a major complaint in 80% of the patients with complete brachial plexus palsy; and, in 80% of these patients, the C5 root is ruptured and the C6-T1 roots avulsed from the spinal cord." | ( Bertelli, JA; Ghizoni, MF, 2014) |
| "Pain is the most prominent symptom of vasoocclusion, and hypercoagulability is a well-established pathogenic phenomenon in people with sickle cell disease." | ( Fedorowicz, Z; van Zuuren, EJ, 2014) |
| "Chronic pain is a major neurological disorder that can manifest differently between genders or sexes." | ( McCarson, KE; Ralya, A, 2014) |
| "Assessing pain is an important element of nursing skills." | ( Clavagnier, I, 2014) |
| "Pain is a common and highly debilitating complication for cancer patients significantly compromising their quality of life." | ( Dickenson, AH; Falk, S; Heegaard, A; Mercadante, S; Patel, R, 2015) |
| "Pain is common in head and neck cancer patients." | ( Miyazaki, T; Nishimura, K; Ohno, T; Satou, S; Yoshida, A, 2014) |
| "Neuropathic pain is caused by a variety of phenomena including sustained excitability in sensory neurons that reduces the pain threshold so that pain is produced in the absence of appropriate stimuli." | ( Abdelhak, B; Frietag, C; Menichella, DM; Miller, RJ; Ren, D; Shum, A, 2014) |
| "Pain is a primary symptom driving patients to seek physical therapy, and its attenuation commonly defines a successful outcome." | ( Bishop, MD; Hannibal, KE, 2014) |
| "Pain is the most common complaint in the medical field and the identification of novel compounds that can effectively treat painful states without causing side effects remains a major challenge in biomedical research." | ( Bonacorso, HG; Correa, MS; Ferreira, J; Oliveira, SM; Otuki, MF; Paim, GR; Prudente, AS; Silva, CR; Wentz, AP, 2014) |
| "Severe pain is a common symptom of sickle cell disease (SCD)." | ( Abrahamson, K; Molter, BL, 2015) |
| "Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception." | ( Huang, Y; Lei, W; Lu, B; Sun, J; Xiao, C; Yao, J; Zhang, H, 2014) |
| "Pain is an important health issue that not only negatively affects the HRQOL but also results in fatigue, dyspnea, disturbed sleep, and financial difficulties in cancer patients." | ( Hara, T; Kido, T; Takahashi, M; Yokoyama, T, 2014) |
| "Pain is a common symptom in patients with multiple myeloma (MM)." | ( Ahmedzai, SH; Boland, J; Chopra, L; Engels, Y; Ezaydi, Y; Foster, A; Gethin, A; Green, T; Sloot, S; Snowden, JA; Verhagen, S; Vissers, K, 2015) |
| "Cancer pain is complex, and despite the introduction of the WHO cancer pain ladder, few studies have looked at the prevalence of adjuvant medication use in an inpatient palliative medicine unit." | ( Davis, MP; Gordon, P; Gross, J; Sharma, P; Shinde, S, 2015) |
| "Pain is recognized as a public health problem in the United States, affecting millions of people of all ages (Committee on Advancing Pain Research, Care, and Education Board on Health Sciences Policy, 2011)." | ( Ward, CW, 2015) |
| "Pain is a common occurrence in the oncology population." | ( Faley, B; Gonzalez, R; Howlett, C; Yerram, P, 2016) |
| "Pain is very common in patients with cancer." | ( Bell, RF; Derry, S; Jackson, KC; Strassels, S; Straube, C; Straube, S; Wiffen, PJ, 2014) |
| "Pain is believed to be undertreated in patients with dementia; however, no larger studies have been conducted." | ( Astrup, A; Gasse, C; Jensen-Dahm, C; Mortensen, PB; Waldemar, G, 2015) |
| "Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional." | ( Delgado Rodrigues, RN; Goulart, LI; Prieto Peres, MF, 2014) |
| "Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning." | ( Navratilova, E; Porreca, F, 2014) |
| "Pain is a major issue for people with many different types of wounds, in particular those people with burn injuries." | ( Cleland, H; Danilla, S; Mahar, PD; McGuinness, SK; Spinks, A; Tan, HB; Wasiak, J, 2014) |
| "Pain is the presenting symptom in 20 to 30% of patients with autosomal dominant polycystic kidney disease (ADPKD) and occurs in 50 to 60% of patients at some stage of the disease process, but its frequency increases with age and size of the cysts." | ( Santoro, D; Satta, E, 2014) |
| "Pain is a major problem in all cancer stages." | ( Besse, K; Engels, Y; te Boveldt, N; Vernooij-Dassen, M; Vissers, K, 2015) |
| "Low-back pain is very frequent, especially in active adult population." | ( Massari, L; Osti, R; Pari, C; Salvatori, G, 2015) |
| "Pain is the most common reason a patient sees a physician." | ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| "However, pain is a major side-effect of this therapy." | ( Graf, B; Gruber, M; Hansen, E; Heinlin, J; Horner, C; Karrer, S; Kerscher, C; Klein, A; Koller, M; Landthaler, M; Szeimies, RM; Werner, A; Zeman, F, 2015) |
| "Pain is one of the most terrifying symptoms for cancer patients." | ( Ay, S; Bozcuk, H; Coskun, HS; Goksu, SS; Karasu, G; Ozdogan, M; Savas, B; Soydas, T; Ulukal, E; Uysal, M, 2014) |
| "Pain is the most common reason for presentation to the emergency department (ED)." | ( Marshall, B; Pretorius, A; Searle, J, 2015) |
| "Pain is commonly experienced by patients with cancer, particularly those with advanced disease." | ( Mercadante, S, 2015) |
| "Cancer pain is one of the most important symptoms of malignant disease, which has a major impact on the quality of life of cancer patients." | ( Chandrasena, C; Schug, SA, 2015) |
| "Cancer-related pain is a significant cause of morbidity in those affected by both primary and metastatic disease." | ( Mauck, WD; Moeschler, SM; Rho, RH; Rosenberg, C; Trainor, D, 2014) |
| "Neonatal pain is often undertreated." | ( Mikos, B, 2014) |
| "Since pain is often present in trauma patients, its effect on the indirect measures of hypovolemia needs to be clarified." | ( Hagen, OA; Hisdal, J; Hoff, IE; Høiseth, LØ; Kirkebøen, KA; Landsverk, SA, 2015) |
| "Moderate or severe pain is common among people with advanced cancer and other life-threatening illnesses." | ( Husain, SA; Joranson, DE; Krakauer, EL; Luong, NK; Maurer, MA; Nguyen, TH; Nguyen, TP, 2015) |
| "Pain is often underreported and poorly managed in these patients." | ( Cleeland, CS; Fallowfield, L; Öhrling, K; Patrick, DL; Qian, Y; von Moos, R; Wei, R, 2015) |
| "Pain is a common and significant symptom experienced by children with advanced malignant disease." | ( Collins, JJ; Mherekumombe, MF, 2015) |
| "Cancer pain is a major public health problem worldwide due to the strong impact on the quality of life of patients and side effects of the existing therapeutic options." | ( Alves, Rdos S; Araújo, AA; Bezerra, DP; Guimarães, AG; Menezes, Pdos P; Oliveira, MA; Quintans Júnior, LJ; Serafini, MR, 2015) |
| "Malignant bone pain is caused by stimulation of peripheral pain receptors, termed nociceptors, which reside in the localized tumor microenvironment, including the periosteal and intramedullary bone cavities." | ( Fadl-Alla, BA; Fan, TM; Lezmi, S; Pondenis, HC; Shor, S; Wycislo, KL; Zhang, X, 2015) |
| "Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood." | ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015) |
| "Bone cancer pain is a common symptom in cancer patients with bone metastases and the underlying mechanisms are largely unknown." | ( Dan, QQ; Deng, YJ; He, M; Liu, J; Liu, W; Meng, FF; Wang, TH; Wang, XY; Wei, L; Xia, QJ; Xu, Y; Zhou, FH, 2015) |
| "Thus, vocalizing in pain is not only communicative." | ( Schirmer, A; Swee, G, 2015) |
| "Pain is a distressing non-motor symptom experienced by up to 85% of people with Parkinson's disease (PD), yet it is often untreated." | ( Allen, NE; Canning, CG; Moloney, N; van Vliet, V, 2015) |
| "Pain is one of the most common and distressing symptoms in patients with cancer, with a high prevalence of 90%." | ( Cho, D; Choe, Y; Choi, J; Han, HS; Kim, J; Lee, K; Lee, KH; Lee, SC; Lim, SN; Park, M; Park, S; Ryoo, HM; Yun, J; Zang, DY, 2015) |
| "Pain is a hallmark of sickle cell disease (SCD) and its treatment remains challenging." | ( Ballas, SK; Gupta, K; Gupta, M; Msambichaka, L, 2015) |
| "Pain is a common and debilitating complication for cancer patients significantly compromising their quality of life." | ( Clausen, RP; Dickenson, AH; Falk, S; Frøsig-Jørgensen, M; Heegaard, AM; Schwab, SD, 2015) |
| "OBJECT Back and leg pain are the primary outcomes of adult spinal deformity (ASD) and predict patients' seeking of surgical management." | ( Ames, CP; Clark, AJ; Eastlack, R; Gupta, M; Hart, RA; Hostin, R; Kebaish, K; Kelly, MP; Kim, HJ; Klineberg, E; Lafage, V; Protopsaltis, TS; Rolston, JD; Scheer, JK; Schwab, F; Shaffrey, CI; Smith, JS, 2015) |
| "Pain is one of the most common and distressing symptoms suffered by patients with progression of cancer." | ( Bao, Y; Gao, Y; Hou, W; Hua, B; Kong, X; Li, C; Yang, L; Zheng, H, 2015) |
| "Chronic pain is a common complication of diabetes." | ( Byrne, FM; Chapman, V; Cheetham, S; Vickers, S, 2015) |
| "Pain is one of the most common symptoms in children and young people (CYP) with life-limiting conditions (LLCs) which include a wide range of diagnoses including cancer." | ( Beecham, E; Bluebond-Langner, M; Candy, B; Howard, R; Jones, L; Laddie, J; McCulloch, R; Rees, H; Vickerstaff, V, 2015) |
| "Pain is the most disruptive influence on the quality of prognosis among head and neck squamous cell carcinoma (HNSCC) patients." | ( Chen, Z; Hu, R; Huang, Y; Jiang, H; Jiang, J; Xu, H; Yan, J; Yang, Y; Zhang, Y, 2015) |
| "Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain areas such as the amygdala and the hippocampus." | ( Abzianidze, EB; Gartsukaia, GP; Nebieridze, MI; Nozadze, IR; Tsagareli, MG; Tsiklauri, ND, 2015) |
| "Neuropathic pain is common in peripheral nerve injury and often fails to respond to ordinary medication." | ( Alberch, J; Boadas-Vaello, P; Puig, T; Turrado, C; Verdú, E; Vidal-Sancho, L; Xifró, X, 2015) |
| "Pain is a syndrome of various clinical disorders, which arises from various pathological conditions and which presents significant challenges in both its diagnosis and treatment." | ( Jakubowska, A; Kulig, K; Sałat, K, 2015) |
| "Cancer pain is a multidimensional symptom for which opioids are the mainstay of treatment." | ( Bruera, E; Chisholm, G; Hui, D; Kwon, JH; Liu, D; Park, JC; Seo, L; Tanco, K; Williams, J; Wong, A, 2015) |
| "Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway." | ( Arakawa, N; Fields, HL; Meske, D; Morimura, K; Navratilova, E; Okun, A; Ossipov, M; Porreca, F; Qu, C; Xie, JY, 2015) |
| "Cancer-induced bone pain is described as dull, aching ongoing pain." | ( King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY, 2015) |
| "Pain is a hallmark of almost all bodily ailments and can be modulated by agents, including analgesics and anesthetics that suppress pain signals in the central nervous system." | ( Agrawal, DK; Hambsch, ZJ; Kerfeld, MJ; Kirkpatrick, DR; McEntire, DM; Reisbig, MD; Smith, TA; Youngblood, CF, 2015) |
| "Chronic pain is managed mostly by the daily administration of analgesics." | ( Alexa, T; Marza, A; Tamba, B; Voloseniuc, T, 2015) |
| "Severe pain is associated with a decreased quality of life in patients with cancer." | ( Bennett, MI; Min, S; Peng, L; Wei, K; Zejun, Z, 2015) |
| "The experience of pain is associated with reactivity of both the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis." | ( Kaess, M; Koenig, J; Rinnewitz, L; Warth, M, 2015) |
| "Pre-surgical pain is very disabling and is viewed as biological." | ( Barrett, E; Gallagher, S; Leov, J; Swain, N, 2017) |
| "Post-obturation pain is frustrating to both patients and dentists." | ( Chu, CH; Li, SK; Wong, AW; Zhang, C; Zhang, S; Zhu, X, 2015) |
| "Neuropathic pain is a debilitating condition in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)." | ( Apostolopoulos, V; Duffy, SS; Fivelman, B; Lees, JG; Makker, PG; Moalem-Taylor, G; Perera, CJ, 2015) |
| "Pain is an important and distressing symptom in Parkinson's disease (PD)." | ( Benetin, J; Hanakova, M; Harsany, J; Martinkova, J; Minar, M; Singliarova, H; Valkovic, P, 2015) |
| "Arthritis pain is an important healthcare issue with significant emotional and affective consequences." | ( Ji, G; Neugebauer, V; Thompson, JM, 2015) |
| "The experience of pain is a highly complex and personal experience, characterized by tremendous inter-individual variability." | ( Khan, HS; Stroman, PW, 2015) |
| "Pain is also associated with depression of many behaviors, and drug effects can differ in assays of pain-stimulated versus pain-depressed behavior." | ( Carroll, FI; Freitas, KC; Negus, SS, 2015) |
| "Chronic muscle pain is a significant health problem leading to disability[1]." | ( Gregory, NS; Sluka, KA; Whitley, PE, 2015) |
| "Leg pain is a common condition in athletes as well as in the general population, and has a broad differential diagnosis that includes musculoskeletal, vascular, rheumatologic, and neurologic etiologies." | ( Howe, BM; Lueders, DR; Sellon, JL, 2016) |
| "Dealing with pain is one of the most important issues of medicine." | ( Akkar, OB; Cetin, A; Cetin, M; Gulturk, S; Kula, A, 2016) |
| "On the other hand, pain is a multidimensional experience with sensory-discriminative and motivational-affective components." | ( Hamada, Y; Igarashi, K; Ikegami, D; Kuzumaki, N; Narita, M; Tamura, H; Watanabe, M, 2015) |
| "Pain is the most common complication of orthodontic treatment." | ( Chiniforush, N; Khatami, M; Rakhshan, V; Shariati, M; Sobouti, F, 2015) |
| "Postpartum pain is a frequent condition that negatively affects women's quality of life, interferring with everyday life." | ( Bounous, VE; Costantino, D; Costantino, M; Guaraldi, C, 2015) |
| "Pain is a common non-motor symptom of Parkinson's disease." | ( Chaudhuri, KR; DeCesare, J; Ehret, R; Hopp, M; Krygowska-Wajs, A; Lomax, M; Marti, MJ; Martinez-Martin, P; Oksche, A; Rascol, O; Reimer, K; Sátori, M; Trenkwalder, C; Vališ, M, 2015) |
| "Itch and pain are unpleasant sensations that distress many patients with disease." | ( Chen, L; Dong, Z; Han, H; Tan, T; Wang, W, 2016) |
| "Animal pain is defined by a series of expectations or criteria, one of which is that there should be a physiological stress response associated with noxious stimuli." | ( Adams, L; Elwood, RW, 2015) |
| "Severe pain is a major problem for cancer patients, and pain management often requires the use of opioids." | ( Irawan, C; Setiabudy, R; Sudoyo, AW, 2015) |
| "Pain is a prevalent, and due to the ageing population, increasing medical problem." | ( Nguyen, V; Pergolizzi, JV; Raffa, RB; Taylor, R, 2015) |
| "Pain is a clinical challenge to health care providers who care for hand disorders." | ( Curtin, C, 2016) |
| "Exertional leg pain is a common condition seen in runners and the general population." | ( Finnoff, JT; Rajasekaran, S, 2016) |
| "Pain is the most common cause of failure of outpatient hysteroscopy." | ( Haggag, H; Hassan, A; Wahba, A, 2016) |
| "Pain is common in the elderly population and its prevalence varies according to the studied disease, clinical setting, sex and age." | ( Berglund, J; Rennemark, M; Wranker, LS, 2016) |
| "Pain is common among older adults and there are significant differences between the sexes." | ( Berglund, J; Rennemark, M; Wranker, LS, 2016) |
| "Still nowadays pain is one of the most common disabling conditions and yet it remains too often unsolved." | ( Aricò, G; Parenti, C; Pasquinucci, L; Ronsisvalle, G; Turnaturi, R, 2016) |
| "Pain is an important protective system that alerts organisms to actual or possible tissue damage." | ( Sakai, A; Suzuki, H, 2015) |
| "Lipid-induced pain is also significantly reduced in ASIC3 knockout mice." | ( Breuil, V; Christin, M; Cognard, C; Delaunay, A; Deval, E; Euller-Ziegler, L; Ferreira, T; Ferru-Clément, R; Friend, V; Lingueglia, E; Marra, S; Noel, J; Roux, C; Sebille, S, 2016) |
| "Pain is a hallmark feature of sickle cell disease (SCD)." | ( Gupta, K; Gupta, M; Jahagirdar, B; Lamarre, Y; Mittal, A, 2016) |
| "Pain is controllable, and patients have a right to not experience pain." | ( Dong, Y; Jiang, F; Yu, J; Zhang, B; Zhang, X; Zhou, T; Zhuang, F, 2016) |
| "Pain is best assessed by self-reporting pain scales; but in patients who are unable to communicate, behavioral pain scales seem to have benefit." | ( Stephens, J; Wright, M, 2016) |
| "Chronic spontaneous pain is a clinically relevant non-motor symptom in multiple system atrophy (MSA) and Parkinson's disease (PD)." | ( Eggert, K; Lefaucheur, JP; Möller, JC; Mylius, V; Oertel, WH; Pape, H; Pee, S; Stamelou, M; Teepker, M, 2016) |
| "Pain is a significant public health concern, and current pharmacological treatments have problematic side effects and limited effectiveness." | ( Hillhouse, TM; Negus, SS, 2016) |
| "Pain is a common and highly distressing symptom in pediatric patients with advanced malignancies." | ( Anghelescu, DL; Baker, JN; Ehrentraut, JH; Snaman, JM, 2016) |
| "Pain is common in men undergoing rigid cystoscopy." | ( Du, GZ; Hu, AM; Liu, J; Qiu, Y, 2016) |
| "Pain is sensed, transmitted, and modified by a variety of mediators and receptors." | ( Endo, Y; Fujita, T; Fukumoto, S; Hagiwara, Y; Mizoguchi, H; Sakurada, S; Shima, K; Sugawara, S; Tadano, T; Takahashi, M; Tsuchiya, M; Watanabe, M, 2016) |
| "Pain is an elemental inducer of avoidance." | ( Dayan, P; Dolan, RJ; Eldar, E; Hauser, TU, 2016) |
| "Pain is a frequent symptom among patients in the hospital." | ( Binswanger, IA; Calcaterra, SL; Doyle, R; Drabkin, AD; Frank, JW; Koester, S; Leslie, SE; Reich, JA, 2016) |
| "Addressing pain is a crucial aspect of emergency medicine." | ( Burton, JH; Donato, M; Echternach, JM; Hoppe, JA; Rodgers, JM, 2016) |
| "Chronic pain is one of the most common non-motor symptoms of Parkinson's disease (PD) affecting up to 85% of patients." | ( Gee, LE; Pilitsis, JG; Ramirez-Zamora, A; Shin, DS; Walling, I, 2016) |
| "Injection pain is a frequent and unpleasant side effect of numerous drugs in clinical use, and previous reports have indicated that the ligand gated ion channels transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) can mediate this effect on sensory neurons." | ( Eberhardt, E; Eberhardt, M; Leffler, A; Schillers, F, 2016) |
| "More severe pain is managed with opioids." | ( Ackermann, RJ; Scheetz, A, 2016) |
| "Fear of dental pain is a major barrier to treatment for children who need dental care." | ( Anand, P; Ashley, PF; MacDonald, LC; Moles, DR; Parekh, S, 2016) |
| "Post-procedural pain is frequent after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), and is only partially prevented by treatment selectivity." | ( Allaham, W; Benzakoun, J; Garcia Alba, C; Lagadec, M; Ronot, M; Sibert, A; Vilgrain, V, 2017) |
| "Pain is a serious health problem that impacts the lives of many individuals." | ( Barbosa, C; Cummins, TR, 2016) |
| "Pain is a complex experience involving sensory and affective components." | ( Amano, T; Hara, T; Ide, S; Kaneda, K; Kaneko, T; Minami, M; Ohno, A; Takahashi, D; Yoshioka, M, 2016) |
| "Cancer pain is an important and distressing symptom that tends to increase in frequency and intensity as the cancer advances." | ( Bao, YJ; Hou, W; Hua, BJ; Knaggs, R; Kong, XY; Xia, J; Yang, L, 2016) |
| "Pain is a disease by itself and it's a public health concern of major implication in children, not just because of the emotional component of the child and his family, but also due to the potential morbidity and mortality involving it." | ( Castillo, T; Rodríguez, MC; Villamor, P, 2016) |
| "Pain is often cited as one of the worst features of medical abortion." | ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "Although pain is one of the most common side effects encountered with medical abortion, little is known about optimal pain management for this process." | ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly." | ( Akassoglou, K; Andreska, T; Barde, S; Eriksson, LI; Harkany, T; Hökfelt, TG; Lei, B; Mathew, JP; Terrando, N; Yang, T; Zhang, MD, 2016) |
| "Inflammatory pain is thought to arise from increased transmission from nociceptors and recruitment of 'silent' afferents." | ( Davis, BM; DeBerry, JJ; Saloman, JL; Smith-Edwards, KM; Woodbury, CJ, 2016) |
| "Pain is the most common complaint in the emergency department (ED), and emergency physicians face unique challenges in making opioid-related treatment decisions." | ( Khidir, H; Weiner, SG, 2016) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| "Kidney pain is a common complication in patients with autosomal dominant polycystic kidney disease (ADPKD), and data from the TEMPO 3:4 trial suggested that tolvaptan, a vasopressin V2 receptor antagonist, may have a positive effect on kidney pain in this patient group." | ( Blais, JD; Casteleijn, NF; Chapman, AB; Czerwiec, FS; Devuyst, O; Gansevoort, RT; Higashihara, E; Leliveld, AM; Ouyang, J; Perrone, RD; Torres, VE, 2017) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Pain is necessary to alert us to actual or potential tissue damage." | ( Altruda, F; Bartsch, S; Castori, M; Chiabrando, D; Di Capua, M; di Rocco, M; Gießelmann, S; Grammatico, P; Hübner, CA; Kurth, I; Madeo, A; Silengo, L; Tolosano, E; Ungelenk, M, 2016) |
| "Pain is a significant side effect of disease, surgery and treatments including chemotherapy." | ( Bennett, M, 2016) |
| "Ear pain is central to children's and parents' experience of the illness." | ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016) |
| "We argue that pain is associated with EEG frontal synchrony and caudal asynchrony, leading to the disruption of cortico-cortical connectivity." | ( Choo, HJ; LeBlanc, BW; Levitt, J; Saab, CY; Smith, KA, 2017) |
| "Chronic pain is treated most commonly with opioid analgesics, anti-inflammatory steroids and nonsteroidal anti-inflammatory drugs." | ( Fischer, BD, 2017) |
| "Pain is associated with several conditions, such as inflammation, that result from altered peripheral nerve properties." | ( Hsieh, CL; Huang, CP; Liao, HY; Lin, YW, 2017) |
| "Pain is a common side effect of orthodontic treatment." | ( Atack, NE; Bradley, R; Deacon, S; Ellis, P; Ewings, P; Griffiths, H; House, K; Ireland, AJ; Jordan, A; Moore, MB; Sandy, JR; Scaysbrook, E; Wenger, N; Williams, JC; Worth, V, 2017) |
| "Chronic back pain is one of the most important complications of postmenopausal osteoporosis." | ( Iino, T; Kato, S; Naito, Y; Nakagawa, T; Sudo, A; Wakabayashi, H, 2017) |
| "Cancer pain is difficult to manage in advanced cancer, especially when delirium is present; however, misinterpretation of delirium symptoms as pain cues may inflate pain judgments." | ( Chan, VWS; Gagliese, L; Mah, K; Rodin, RA; Stevens, BJ; Zimmermann, C, 2017) |
| "Pain is fundamentally unpleasant and induces a negative affective state." | ( Almoosawi, N; Engblom, D; Frisch, I; Fritz, M; Jaarola, M; Klawonn, AM; Mirrasekhian, E; Singh, AK; Zajdel, J, 2017) |
| "Pain is the most frequent complaint of burn-injured patients." | ( Eitan, S; Emery, MA; Shawn Bates, ML; Wellman, PJ, 2017) |
| "Pain is a common complaint among postmenopausal women." | ( Evans, HM; Howe, PRC; Wong, RHX, 2017) |
| "Musculoskeletal pain is the most common type of pain in patients with PD." | ( Fu, YT; Huang, JY; Li, J; Liu, CF; Liu, JY; Ma, LJ; Mao, CJ; Wang, Y; Zhang, HJ, 2018) |
| "Pain is one of the most commonly reported symptoms in people living with HIV/AIDS, whether or not they are receiving anti-retroviral therapy." | ( Jelsma, J; Parker, R; Stein, DJ, 2017) |
| "Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time." | ( Coluzzi, F; Fornasari, D; Pergolizzi, J; Romualdi, P, 2017) |
| "Patients with pain are at higher risk of suicide." | ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017) |
| "Pain is a subjective and complex phenomenon." | ( Reddan, MC; Wager, TD, 2018) |
| "Pain is one of the most frequent symptoms in patients with advanced chronic illnesses." | ( Jespersen, BA; Neergaard, MA, 2017) |
| "Pain is a common and distressing symptom of pediatric cancer, as reported by both children and their parents." | ( Barwick, M; Campbell, F; Chambers, CT; Fernandez, CV; Irwin, K; Jibb, LA; Nathan, PC; Parker, JA; Stinson, JN; Tutelman, PR; Witteman, HO, 2018) |
| "Pain is a severe and debilitating complication of metastatic bone cancer." | ( Andersen, L; Appel, CK; Blancheflor Kristensen, S; Ding, M; Falk, S; Gabel-Jensen, C; Gallego-Pedersen, S; Heegaard, AM; Sayilekshmy, M, 2017) |
| "Knee pain is one of the most common symptoms of knee osteoarthritis (OA) that affects the quality of life in the older adults, and identifying the contributing factors of knee pain is important." | ( Chang, CB; Han, HS; Lee, DC; Lee, JY, 2017) |
| "Treat the Pain is supporting governments in Sub-Saharan Africa to reduce needless suffering and improve access to essential pain medicines for patients in pain by supporting the expansion of locally produced, affordable oral morphine solution and expanding basic training in pain assessment and management." | ( O'Brien, M; Plattner, L; Schwartz, A, 2018) |
| "Pain is a frequent non-motor feature in Parkinsonism but mechanistic data on the alteration of pain processing are insufficient to understand the possible causes and to define specifically-targeted treatments." | ( Avenali, M; De Icco, R; Fresia, M; Pacchetti, C; Perrotta, A; Sandrini, G; Serrao, M; Tassorelli, C, 2017) |
| "Pain is an efficient outcome measure for predicting broader patient response in osteoarthritis." | ( Chen, WJ; Gates, DF; Lin, HY; Moore, RA; Peloso, PM; Popmihajlov, Z; Straus, WL, 2016) |
| "Pain is a defense mechanism of the body that entails physiological, anatomical, neurochemical, and psychological changes, and is defined as an unpleasant sensory and emotional experience with potential risk of tissue damage, comprising the leading cause of appointments with Physicians worldwide." | ( Alfaro-Rodríguez, A; Bandala, C; Carrillo-Mora, P; Cortes-Altamirano, JL; Jaime, HB; Olmos-Hernandez, A; Reyes-Long, S, 2018) |
| "Pain is often associated with a more rapid progression of cognitive and functional decline, and behavioral disturbance in dementia." | ( Han, SH; Kim, YS; Lee, J; Moon, Y, 2017) |
| "Neuropathic pain is the most severe and resistant type of pain which has impact on quality of life and behaviour; it most commonly occurs at night causing disturbed sleep." | ( Jawed, I; Kamil, A; Khan, MI; Mahmood, I; Mahmood, R; Sayeed, BZ; Sayeed, FZ; Tariq, T, 2017) |
| "As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs." | ( Molden, E; Solhaug, V, 2017) |
| "Pain is a complex experience with both sensory and affective components." | ( Deyama, S; Ide, S; Kaneda, K; Maruyama, C; Minami, M; Nagano, Y; Yoshioka, M, 2018) |
| "Chronic pain is a major global public health issue causing a severe impact on both the quality of life for sufferers and the wider economy." | ( Aloisi, AM; Bachiocco, V; Bennett, DLH; Bogdanov, YD; Bras, JT; Cox, JJ; Emery, EC; Follenfant, M; Gossage, SJ; Gras, M; Habib, AM; Houlden, H; Humphrey, J; Kolesnikov, A; Komine, Y; Le Cann, K; Li, S; Maniatis, N; Marsili, L; Matsuyama, A; Minett, MS; Okorokov, AL; Panov, KI; Pereira, V; Ponsolles, C; Ramirez, JD; Santana-Varela, S; Sikandar, S; Torres, JM; Wood, JN; Yamamori, T; Yamaoka, K; Zhao, J, 2018) |
| "Trochlear pain is frequently overlooked as published data regarding the clinical characteristic and current treatment are limited." | ( Chanlalit, W; Soodchuen, S; Teeyapant, C, 2018) |
| "Pain is a widely neglected symptom in patients with amyotrophic lateral sclerosis (ALS), even though it may be common and have a significant impact on the quality of life." | ( Aono, H; Hanamitsu, H; Hatta, H; Hirutani, M; Hongo, S; Ishida, N; Kumano, A; Suzuki, R; Takahashi, M; Tuigi, M; Wakasugi, E; Yamamoto, Y; Yamatani, A; Zakoji, N, 2018) |
| "Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage." | ( Gómez, KV; Majdalani, A; Pigliapoco, V; Santos Chocler, G; Yazde Puleio, ML, 2018) |
| "Pain is mediated by primary sensory neurons (nociceptors) that can respond to a variety of thermal, mechanical and chemical signals." | ( Christensen, AD; Cook, AD; Hamilton, JA; McMahon, SB; Tewari, D, 2018) |
| "Pain is a very complex biochemical and electrical process involving sensory part, nerve transmission, and brain perception of pain." | ( Cosic, D; Cosic, I, 2017) |
| "Pain is one of the most common and troublesome non-motor symptoms of Parkinson's disease (PD)." | ( Abbruzzese, G; Antonini, A; Berardelli, A; Chaudhuri, KR; Defazio, G; Ferreira, J; Martinez-Martin, P; Rascol, O; Tinazzi, M; Trenkwalder, C, 2018) |
| "Hunger and pain are two competing signals that individuals must resolve to ensure survival." | ( Alhadeff, AL; Betley, JN; De Jonghe, BC; Guo, C; Hantman, AW; Hernandez, E; Holland, RA; Klima, ML; Phillips, SZ; Su, Z, 2018) |
| "Pain is one of the most prevalent, costly and disabling conditions that reduces quality of life." | ( Anversa, RG; Birmann, PT; Bruning, CA; Lenardão, EJ; Lima, DB; Savegnago, L; Sousa, FSS, 2018) |
| "Pain is one of the common and debilitating health manifestations associated with the majority of diseased conditions, thus making it a serious health concern worldwide." | ( Dhillon, H; Singh, S, 2018) |
| "Although pain is one of the most common afflictions, it is often inadequately managed because the available analgesic options are relatively limited due to insufficient efficacy, unacceptable adverse effects or the potential for misuse or abuse." | ( Ossipov, MH; Pergolizzi, JV; Raffa, RB; Taylor, R, 2018) |
| "Pain is complex, difficult to understand and diagnose, and especially enigmatic to manage." | ( Atkinson, TJ; Bryant, C; Crumb, MW, 2018) |
| "Significant pain is common in patients hospitalized in an internal medicine department, but the pain is mostly short term and pain control is adequate despite the restricted use of opioid therapy during hospitalization." | ( Froom, P; Shimoni, Z; Varon, D, 2018) |
| "Inflammatory pain is a complex and multifactorial disorder." | ( Bouali-Benazzouz, R; Favereaux, A; Landry, M; Tell, G; Zaky, A, 2018) |
| "Pain is the leading reason for seeking health care, and mu opioid receptor agonists continue to be prescribed despite well-documented adverse effects." | ( France, CP; Lu, HY; Minervini, V; Osteicoechea, DC; Padarti, J, 2018) |
| "Pain is a global public health problem because the burden of acute and chronic pain is considerable and is continuously increasing." | ( Jukić, M; Puljak, L, 2018) |
| "Itch and pain are refractory symptoms of many ocular conditions." | ( Davidson, S; Duan, B; Guo, C; Huang, AJW; Huang, CC; Huang, T; Jiang, H; Li, F; Liu, Q; Xiao, M; Yang, W; Yu, G, 2018) |
| "Pain is a prevalent and debilitating symptom of multiple sclerosis (MS); yet, the mechanisms underlying this pain are unknown." | ( Bosma, RL; Cheng, JC; Davis, KD; Hemington, KS; Kim, JA; Oh, J; Osborne, NR; Rogachov, A, 2018) |
| "Pain is prevalent in cancer patients, appearing to be moderate to severe in more than one third of them." | ( Galanos, A; Mystakidou, K; Panagiotou, I; Roumeliotou, A; Symeonidi, M; Tsilika, E, 2018) |
| "Leg pains are more frequent in those with CHD compared with their healthy siblings." | ( Chaudhry, B; Coats, L; Crossland, DS; Hutchinson, S, 2018) |
| "Pain is a common experience for most patients in the intensive care unit (ICU)." | ( Dehcheshmeh, HS; Johnston, TP; Joneidi-Jafari, N; Mojtahedzadeh, M; Panahi, Y; Sahebkar, A, 2018) |
| "Abdominal pain is a relatively common complaint during pregnancy, and a methodical approach should be taken when evaluating LUQ in pregnancy." | ( Chin, JM; Schlueter, RJ; Wong, JW, 2018) |
| "Experiences of pain are not associated with decisions about whether or not to use cannabis." | ( Baruch, YB; Gelkopf, M; Greene, T; Sznitman, S, 2018) |
| "Pain is a highly prevalent problem in older adults and dying patients." | ( Janssen, DJA; Martens, MJM; Schols, JMGA; van den Beuken-van Everdingen, MHJ, 2018) |
| "Pain is the most common complaint for an emergency department (ED) visit, but ED pain management is poor." | ( Aitken, A; Duncan, R; Haase, D; Jones, K; Nguyen, T; Rea, J; Rubinson, L; Tiffany, L; Tran, QK; Tuteja, G, 2018) |
| "Pain is associated with negative emotions such as anxiety, but the underlying neurocircuitry and modulators of the association of pain and anxiety remain unclear." | ( Bouali-Benazzouz, R; Covita, J; Egron, K; Favereaux, A; Fossat, P; Gundlach, AL; Landry, M; López-González, MJ; Ma, S; Roca-Lapirot, O; Trigilio, G, 2019) |
| "Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment." | ( Baudouin, C; Ben-Dhaou, C; Melik Parsadaniantz, S; Ouimet, T; Poras, H; Reaux-Le Goazigo, A; Wurm, M, 2019) |
| "Also, although pain is difficult to assess in this group, the impact on QoL is probably considerable." | ( Achterberg, WP; Caljouw, MAA; Gussekloo, J; Husebo, BS; van Dam, PH, 2018) |
| "Pain is a significant public health problem that needs policy at the national and local level to resolve incidents of insufficient, ineffective, and disparate pain treatment while limiting the risk of inadvertently increasing the use of treatment such as opioids that can result in public harm." | ( Gordon, DB; Gross, J, 2019) |
| "Chronic pain is a massive socieoeconomic burden and is often refractory to treatment." | ( Borgland, SL; Huang, S; Zamponi, GW, 2019) |
| "This severe pain is mostly refractory to palliative analgesic treatment, and the latter was only detected by specific and sensitive outcomes." | ( Beauchamp, G; Blair, J; de Lorimier, LP; Lussier, B; Monteiro, BP; Moreau, M; Pelletier, JP; Troncy, E, 2018) |
| "Nipple pain is the second most common reason for early weaning, exceeded only by the insufficient milk supply." | ( Bolognesi, LFC; Borges, FA; de Barros, NR; Dos Santos, RS; Herculano, RD; Marques, RFC; Miranda, MCR; Norberto, AMQ; Schiavon, JV, 2019) |
| "Pain is a common symptom among patients with cancer, yet pain prevalence and management in older cancer pts." | ( Ahcene-Djaballah, S; Brunello, A; Dadduzio, V; Fiduccia, P; Guglieri, I; Lettiero, A; Lonardi, S; Maruzzo, M; Schiavon, S; Tierno, G; Zagonel, V, 2019) |
| "Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target." | ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019) |
| "Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control." | ( Largent-Milnes, TM; Thompson, AL; Vanderah, TW, 2019) |
| "Prehospital acute pain is a frequent symptom that is often inadequately managed." | ( Christensen, EF; Friesgaard, KD; Giebner, M; Kirkegaard, H; Nikolajsen, L; Rasmussen, CH, 2019) |
| "Chronic pain is a major clinical problem with limited treatment options." | ( Hu, L; Hu, XF; Li, HP; Li, M; Lin, LX; Liu, WT; Pan, HL; Shu, Y; Xiang, HC; Zhang, RY; Zhao, YL; Zhu, H, 2019) |
| "Pain is reported as the most bothersome nonmotor symptom in PD; however, pain remains overlooked and poorly understood." | ( Berzuino, MB; Campos, ACP; Domenici, RA; Fonoff, ET; Hernandes, MS; Maciel, ST; Pagano, RL, 2019) |
| "Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction." | ( Andreassen, KV; Dąbrowska, A; Ding, M; Henriksen, K; Karsdal, MA; Katri, A; Löfvall, H; Thudium, CS, 2019) |
| "Pain is the main cause of disability from arthritis." | ( Blanshan, N; Dorman, C; Frizelle, S; Krug, HE; Mahowald, M, 2019) |
| "Burn pain is one of the worst imaginable pain, associated with considerable morbidity and mortality worldwide." | ( Ali, H; Khalid, S; Khan, A; Khan, S; Kim, YS; Shal, B, 2019) |
| "Pain is an unpleasant side-effect that can be experienced during orthodontic procedures including debonding of fixed appliances." | ( Alharbi, F; Almuzian, M; Alomari, S; Mohammed, H; Rizk, MZ; Ulhaq, A, 2019) |
| "Arthritis pain is heterogeneous - there are trajectories of people whose pain gets better or worse." | ( Ferguson, E; James, RJE; Walsh, DA, 2019) |
| "Chronic pain is commonly accompanied with anxiety disorder, which complicates treatment." | ( Guan, SY; Hu, LN; Liu, A; Liu, SB; Lu, L; Tian, Z; Wang, XS; Yang, LK; Yue, J; Zhang, K; Zhao, MG, 2019) |
| "Mild pain is usually managed quite well with oral acetaminophen or ibuprofen." | ( Harirforoosh, S; Odle, BL; Thigpen, JC, 2019) |
| "Pain is the most ubiquitous and costly disease in society and yet all of our "treatments" have toxicities, especially for prolonged use." | ( Hruby, VJ, 2019) |
| "Pain is a common nonmotor symptom of Parkinson's disease (PD) that remains neglected and misunderstood." | ( Berzuino, MB; Campos, ACP; Fonoff, ET; Hernandes, MS; Pagano, RL, 2019) |
| "Pain is a common complaint among the aging population, particularly among the older residents of nursing homes." | ( Biglarian, A; Foroughan, M; Jafari, Z; Rashedi, V; Shahboulaghi, FM, 2019) |
| "Chronic pain is common among older residents of nursing homes and deteriorates their quality of life." | ( Biglarian, A; Foroughan, M; Jafari, Z; Rashedi, V; Shahboulaghi, FM, 2019) |
| "Pain is a core complaint among rheumatoid arthritis (RA) patients, and persistent pain requires treatment adjustments according to current strategies." | ( Arce-Salinas, CA; Espinosa-Ortega, HF; Ruiz-Medrano, E, 2019) |
| "Pain is a major symptom of patients visiting the emergency department (ED), with up to 42% of ED visits being related to pain (2)." | ( Rui, P; Schappert, SM, 2019) |
| "The way pain is remembered seems to depend on certain factors, including the type of pain or, in other words, its cause, the context, and the meaning it has for the person suffering from it." | ( Bąbel, P; Farley, D; Piszczek, Ł, 2019) |
| "Pain is a natural bioassay for detecting and quantifying biological activities of venoms." | ( Schmidt, JO, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "Chronic pain is a worldwide major health problem and many pain-suffering patients are under opioid based therapy." | ( Agustín-Pavón, C; Campos-Jurado, Y; Granero, L; Hipólito, L; Igual-López, M; Padilla, F; Polache, A; Zornoza, T, 2019) |
| "Chronic pain is associated with altered affective state, stress, anxiety and depression." | ( Abelson, KS; Brønnum Pedersen, T; Hestehave, S; Munro, G, 2019) |
| "Pain is by far the most common diagnosis in cannabis drugs." | ( Broich, K; Cremer-Schaeffer, P; Schmidt-Wolf, G, 2019) |
| "Chronic pain is the most common indication, as health claims data and the accompanying survey show." | ( Gastmeier, K; Häuser, W; Karst, M; Petzke, F; Radbruch, L; Steffen, E, 2019) |
| "Pain is a major primary health care problem." | ( Chen, YH; Hsu, SF; Hung, SY; Lin, JG; Lin, PL; Luo, ST; MacDonald, I; Yang, CT, 2019) |
| "Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients." | ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020) |
| "Pain is a common distressing symptom in children receiving pediatric palliative care." | ( Friedrichsdorf, SJ; Postier, AC, 2019) |
| "Knee pain is often underreported, underestimated and undertreated." | ( Abbas, AA; Chan, CK; Chin, AV; Cumming, RG; Hairi, NN; Jaafar, MH; Kamaruzzaman, SB; Mat, S; Ng, CT; Othman, S; Raja, J; Sockalingam, S; Tan, MP; Tey, NP, 2019) |
| "Neuropathic pain is a chronic pain caused by central and peripheral nerve injury, long-term diabetes or treatment with chemotherapy drugs, and it is dissimilar to other chronic pain conditions." | ( Bán, EG; Brassai, A; Vizi, ES, 2020) |
| "Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear." | ( Cao, X; Cao, Y; Chen, H; Crane, JL; Demehri, S; Deng, R; Dong, X; Guan, Y; Hu, B; Hu, J; Jain, A; Li, Y; Ling, Z; Lu, H; Lyu, X; Ni, S; Pan, D; Qi, H; Skolasky, R; Wan, M; Wang, X; Wu, P; Wu, T; Zhen, G; Zou, X, 2019) |
| "Arthritic pain is the main unpleasant component of rheumatoid arthritis." | ( Anselmo-Franci, JA; Branco, LGS; Carolino, ROG; Mota, CMD; Rodrigues-Santos, C, 2020) |
| "Burn injury pain is a significant public health problem." | ( Eitan, S; Emery, MA, 2020) |
| "These shifts in pain care have led to new pain management strategies that rely on multidisciplinary teams and nonpharmacologic pain treatments." | ( Brummett, B; Higgins, DM; Holtzheimer, P; Martino, S; Mattocks, K; Ngo, T; Reznik, TE; Rosen, MI; Sellinger, J; Semiatin, AM; Stapley, T, 2020) |
| "Pain is a non-motor symptom in Parkinson's disease (PD) which commonly goes underreported." | ( Bruno, V; Farcy, N; Karnik, V; Zamorano, C, 2020) |
| "Although pain is the cardinal symptom of arthritis, which is directly related to function and quality of life, the elucidation of the mechanism underlying the pathogenesis of pain in arthritis has lagged behind other areas, such as inflammation control and regulation of autoimmunity." | ( Hong, JI; Kim, HA; Park, IY, 2020) |
| "pain is one of the most often symptoms experienced by patients with advanced or chronic diseases which can cause a decrease in the quality of life of palliative patients." | ( Abdullah, V; Adli, M; Agung, RA; Elita, D; Irawan, C; Putranto, R; Shatri, H, 2019) |
| "Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN) is the most important mediating mechanism." | ( Cunha, FQ; Cunha, TM; Gomes, FIF, 2020) |
| "However, cancer pain is gradually alleviated about two weeks after radiotherapy." | ( Wang, Y; Xing, L, 2020) |
| "As ongoing pain is one of the main pain symptoms of patients, an animal model that illuminates this problem is highly anticipated." | ( De Clercq, K; Luyten, K; Persoons, E; Pinto, SJPC; Tomassetti, C; Van Bree, R; Van den Eynde, C; Voets, T; Vriens, J, 2020) |
| "Since cancer pain is caused by both tumor and chemotherapy, we assessed the efficacy of drugs from the WHO analgesic ladder for cancer pain relief in a paclitaxel-induced pain syndrome (P-IPS) model." | ( Brusco, I; Ferreira, J; Hausen, BDS; Moresco, RN; Oliveira, SM; Pinheiro, KV; Rigo, FK, 2020) |
| "Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated." | ( Ase, AR; Ribeiro-da-Silva, A; Séguéla, P; Sharif, B, 2020) |
| "Pain is the most common complaint and often thought to be undertreated, which can negatively influence the child's care and increase the risk of posttraumatic stress disorder." | ( Bielsky, A; Goldsmith, A; Meier, M; Moulton, S; Phillips, R; Recicar, J; Shahi, N; Shirek, G; Yaster, M; Zuk, J, 2020) |
| "However, pain is often a prominent symptom in patients with malignant and nonmalignant serious illness and providers have to be adept at balancing effective pain management and safety." | ( Curseen, KA; Grant, Q; Taj, J, 2020) |
| "Although pain is a prevalent nonmotor symptom in Parkinson's disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms." | ( Cao, JL; Gu, W; Luan, Y; Tang, D; Wu, H; Wu, Y; Xiao, C; Zhou, C, 2020) |
| "Pain is a prevalent symptom at the end of life and negatively impacts quality of life." | ( Bush, SH; Hagarty, AM; Lapenskie, J; Talarico, R; Tanuseputro, P, 2020) |
| "Severe pain is defined using a validated pain scale combining pain frequency and intensity: daily pain of severe intensity." | ( Bush, SH; Hagarty, AM; Lapenskie, J; Talarico, R; Tanuseputro, P, 2020) |
| "Pain is a common fear of those contemplating end of life, but severe pain is reported in less than 1 in 5 of our population in the last month of life." | ( Bush, SH; Hagarty, AM; Lapenskie, J; Talarico, R; Tanuseputro, P, 2020) |
| "Propofol injection pain is a very common problem during the induction of general anesthesia." | ( Ji, L; Lan, Y; Sun, W; Wu, Q; Xia, C; Xu, X; Yang, S; Yu, G, 2020) |
| "This definition of pain is cited in a lot of books." | ( Watanabe, K, 2020) |
| "Pain is a global health priority that is challenging to asses." | ( Ahmed, F; Cabot, PJ; Hall, WD; Mueller, JF; O'Brien, JW; Thomas, KV; Tscharke, B, 2020) |
| "Pain is evolutionarily hardwired to signal potential danger and threat." | ( Bingel, U; Elsenbruch, S; Forkmann, K; Schmidt, K, 2020) |
| "Pain is a common and disabling non-motor symptom (NMS) of Parkinson's disease (PD), which occurs through the course of the disease, often unrecognized and undertreated." | ( Bovi, T; Di Vico, IA; Geroin, C; Segatti, A; Squintani, G; Tinazzi, M, 2020) |
| "Pain is one of the main symptoms in 60 to 90 % of cancer patients." | ( Elsner, F; Hiddemann, S; Lampert, A; Neuner, I; Peuckmann-Post, V; Rolke, R; Stingl, J; Weber, S, 2020) |
| "Pain is a major concern associated with conventional photodynamic therapy (C-PDT)." | ( Cao, Y; Shi, L; Wang, P; Wang, X; Zhang, G; Zhang, H; Zhang, Y; Zhou, Z, 2020) |
| "Pain is a common symptom in pediatric patients with cancer, and most patients in palliative care will receive opioids." | ( Marks, A; Quirk, K; Smith, MA; Wright, J, 2020) |
| "Chronic pain is common in adult patients with CF and management presents a formidable challenge to providers." | ( Andrew T, B; Anita, L; Catherine, D; Trina, H; Yaoli, Y; Zubin, M, 2021) |
| "Pain is the most common symptom, and presentation of the disease may depend on which bones are affected, the extent of involvement, and the presence of complications." | ( des Bordes, JK; Rianon, NJ, 2020) |
| "Pathological pain is regulated by a balance between pro-algesic and analgesic mechanisms." | ( Celik, MÖ; Machelska, H, 2020) |
| "Pain is one of the most common and debilitating symptoms of hidradenitis suppurativa (HS)." | ( Borgstrom, M; Fernandez, JM; Hsiao, JL; Orenstein, LAV; Shi, VY; Thompson, AM, 2022) |
| "Pain is one of the most common medical challenges, reducing life quality." | ( Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H, 2020) |
| "Pain is poorly managed in patients with kidney disease." | ( Dember, LM; Jhamb, M; Liebschutz, J; Roy, PJ; Weltman, M, 2020) |
| "Pain is a hallmark of this condition and can be extremely difficult to control." | ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020) |
| "Drugs used to treat pain are associated with adverse effects, increasing the search for new drugs as an alternative treatment for pain." | ( Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH, 2020) |
| "Pain is an unpleasant sensation that has complex and varying causative etiology." | ( Afroz, M; Hasan, MF; Islam, MT; Mubarak, MS; Rouf, R; Sarker, DK; Shilpi, JA; Uddin, SJ, 2021) |
| "Pain is a common symptom among patients with kidney disease." | ( Balkrishnan, R; Han, Y; He, K; Hirth, RA; Hutton, DW; Saran, R; Steffick, DE, 2020) |
| "Pain is a frequent finding in surgical and trauma patients, and effective pain control remains a common challenge in the hospital setting." | ( George, S; Johns, M, 2020) |
| "Although severe pain is a major clinical manifestation of SCD, it remains unknown whether nociception plays a role in SCD pathogenesis." | ( Frenette, PS; Gulinello, M; Xu, C, 2021) |
| "Pain is a serious adverse event which frequently accompanies hematopoietic stem cell transplantation (HSCT)." | ( Gordon, L; Grosshans, N; Mehta, J; Rubin, H; Trifilio, S, 2021) |
| "Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage." | ( Pick, CG; Schreiber, S, 2021) |
| "Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of people on a daily basis." | ( Thyagarajan, B; Wang, M, 2022) |
| "Pain is an unpleasant sensory and emotional experience, often accompanied by the occurrence of a variety of diseases." | ( Li, W; Liao, X; Liu, Y; Su, Y; Wang, Q; Xu, Y; Yu, Y; Zhang, J; Zhang, S; Zhao, M, 2021) |
| "Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients." | ( Čeko, M; Kim, HJ; Kim, SG; Lee, JJ; Lee, SA; Park, BY; Park, H; Roy, M; Wager, TD; Woo, CW, 2021) |
| "Pain is a complex, unpleasant feeling and emotional experience associated with actual or potential tissue damage, and manifests itself in certain autonomous psychological and behavioral responses." | ( Lin, S; Tian, GH; Wang, LY; Wei, XH; Xia, GY; Xia, H, 2020) |
| "Although rectal pain is often not commonly associated with prolapse, it bothers many women and motivates older women to undergo evaluation." | ( Arnow, KD; Gurland, BH; Lee, A; Neshatian, L; Trickey, AW, 2021) |
| "Pain is an immunological response to an infection or inflammation and long-term use of pain management therapy includes the use of Nonsteroidal anti-inflammatory drugs, which is associated with the occurrence of toxicity as well as gastrointestinal bleeding." | ( Gaikwad, NJ; Gaikwad, SS; Patil, ML, 2021) |
| "Chronic pain is conceptualized as a persistent negative shock to lifetime utility that can be treated by pain relief medication." | ( Strulik, H, 2021) |
| "Although pain is a common symptom in the general population, impairments in glucose regulation alone does not seem to increase pain among older individuals." | ( Åström, MJ; Eriksson, JG; Haanpää, M; Kautiainen, H; Salonen, MK; von Bonsdorff, MB, 2021) |
| "Pain is a noxious stimulus caused due to tissue damage and varies from mild to severe." | ( Bhatnagar, A; Hasan, N; Jain, GK; Karwasra, R; Khan, N; Khanna, K; Khanna, S; Kumar, A; Nishad, DK; Popli, H; Rawat, S; Sharma, N, 2021) |
| "Chronic pain is a major global health issue that affects all populations regardless of sex, age, ethnicity/race, or country of origin, leading to persistent physical and emotional distress and to the loss of patients' autonomy and quality of life." | ( Côté, J; Marchand, S; Midavaine, É; Sarret, P, 2021) |
| "Chronic pain is highly comorbid with affective disorders, including major depressive disorder." | ( Donaldson, LF; Lumb, BM; Phelps, CE; Robinson, ES, 2021) |
| "Pain is one of the major symptoms complained about by patients in the prehospital setting, especially in the case of trauma." | ( Albrecht, R; Berger, Y; Grünenfelder, A; Meuli, L; Pietsch, U; Schurter, D; Theiler, L; Wenzel, V, 2021) |
| "Pain is a major comorbidity of sickle cell disease (SCD)." | ( Gupta, K; Mittal, A; Sagi, V; Tran, H, 2021) |
| "Pain is a phenomenon present in the majority of the population, affecting, among others, the elderly, overweight people, and especially recently operated patients, analgesia being necessary." | ( de Andrade, ARB; de Britto Lira Nogueira, MC; de Santana, DP; de Siqueira Ferraz-Carvalho, R; Gibson, VP; Kishishita, J; Leal, LB; Santos-Magalhães, NS, 2021) |
| "Burn pain is known to be excruciating, and while burn care has greatly advanced, treatment for burn-related pain is lacking." | ( Furer, A; Giladi, S; Goder, D; Zilberman, M, 2021) |
| "Pain is one of the cardinal signs accompanying inflammation." | ( Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A, 2021) |
| "Pain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions." | ( Beaudet, N; Bégin-Lavallée, V; Belkouch, M; Dansereau, MA; Longpré, JM; Mélik-Parsadaniantz, S; Midavaine, É; Sarret, P, 2021) |
| "Bumetanide-induced pain is more common than previously described." | ( Brighton, DD; Herges, JR; Herges, LB; Jentzer, JC; Ou, NN, 2021) |
| "Pain is a common side effect of intravenous injection of propofol." | ( Choice, C; Greige, N; Hwang, LK; Larios-Valencia, J; Nash, DW; Pothula, A; Yedlin, A, 2021) |
| "Persistent pain is a prevalent symptom of Parkinson's disease (PD), which is related to the loss of monoamines and neuroinflammation." | ( Assis, DV; Barbosa, GR; Berzuíno, MB; Campos, ACP; Fonoff, ET; Freire, HMRC; Lopes, PS; Pagano, RL, 2021) |
| "Pain is a symptom of ninety percent of human diseases, and pain management is a very important medicinal problem." | ( Laev, SS; Salakhutdinov, NF, 2021) |
| "Pain is a known complication in persons with hemophilia (PWH) as a result of muscle and joint bleeding." | ( Baumann, K; Buckner, T; Curtis, RG; Durben, N; Fritz, R; Humphrey, C; Humphries, TJ; Lambing, AY; Mauer, K; Newman, J; Nichols, CD; Santaella, M; Thibodeaux, CB; Wheat, E; Witkop, M, 2022) |
| "Pain is a core domain of psoriatic arthritis (PsA)." | ( Azevedo, V; Bushmakin, AG; Cappelleri, JC; de Vlam, K; Fallon, L; Fleischmann, R; Mease, PJ; Ogdie, A; Taylor, PC; Woolcott, J, 2021) |
| "Although persistent pain is estimated to affect about 20% of the adult population, current treatments have poor results." | ( Georgoussi, Z; Parenti, C; Pasquinucci, L; Reina, L; Tomarchio, E; Turnaturi, R, 2021) |
| "Pain is a common but often ignored symptom in COVID-19 patients." | ( Sir, E, 2021) |
| "Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptor subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial." | ( Al-Madol, M; Khalefa, BI; Li, L; Mousa, SA; Schäfer, M; Shaqura, M; Treskatsch, S, 2021) |
| "Residual limb pain is common after amputation." | ( Lui, G; Sussman, WI, 2021) |
| "Pain is a complex problem, particularly in underserved populations." | ( Ahmed, E; Chen, J; Dhingra, L; Dieckmann, NF; DiFiglia, S; Ginzburg, R; Nosal, S; Portenoy, R; Rodriguez, S; Schiller, R; Schroff, N; Shuman, S; Teets, R, 2021) |
| "Chronic pain is induced and supported by proinflammatory cytokines, free radicals, and reactive oxygen species creating a self- sustaining vicious circle." | ( Cannavò, L; Di Rosa, G; Gitto, E; Marseglia, L; Perrone, S; Viola, V, 2022) |
| "Pain is currently understood to be an important phenotype that those two neurohormones strongly downregulate." | ( Hwang, SW; Jung, ST; Kim, Y; Lim, JY; Zheng, H, 2021) |
| "Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom." | ( Elisei, L; Galdino, G; Malta, I; Moraes, T; Novaes, R, 2022) |
| "Pain is associated with increased risk for harmful substance use." | ( Burke, C; McKee, SA; Moore, KE; Peltier, MR; Roberts, W; Verplaetse, TL; Zakiniaeiz, Y, 2021) |
| "Bone pain is the primary problem for patients with osteoporosis." | ( Ge, Y; Li, H; Lin, Y; Lin, Z; Tang, B; Tian, Y; Wang, K; Wang, Y; Wu, Y; Zhang, J, 2021) |
| "Pain is common among cirrhosis patients, particularly those hospitalized with acute illness." | ( Auerbach, A; Hohmann, SF; Lai, JC; Rubin, JB; Shui, AM, 2023) |
| "Pain is highly prevalent among older people, and treatment is complicated because of comorbidities and polypharmacy." | ( Gustafsson, M; Lövheim, H; Sjölander, M, 2021) |
| "Pain is a common and debilitating symptom of inflammatory bowel disease (IBD)." | ( Gold, MS; Loeza-Alcocer, E, 2022) |
| "Pain is still an underestimated symptom in CF patients." | ( Brinkmann, F; Dillenhöfer, S; Hoffmann, AT; Lücke, T; Maier, C, 2022) |
| "Pain is one of the most severe concerns in tongue cancer patients." | ( Asano, S; Furukawa, A; Hayashi, Y; Hitomi, S; Iwata, K; Kaneko, T; Koyama, R; Shibuta, I; Shinoda, M; Yonehara, Y, 2021) |
| "Pain is a frequent adverse event during photodynamic therapy, which can limit treatment acceptance." | ( Ag, S; Er, O; Ha, M; Lpf, A; Mb, R; Mmc, M; Mr, G, 2022) |
| "Pain is a physiological response to bodily damage and serves as a warning of potential threat." | ( Contreras, JE; Griffith, TN; Muñoz, MF, 2021) |
| "Pain is one of the most distressing symptoms for patients with advanced cancer." | ( Jarlbæk, L; Rasmussen, SS, 2021) |
| "Periodontal pain is a public health problem derived from different conditions, including periodontal diseases, prosthetic complications, and even extractions performed by dentist." | ( Caballero-Florán, IH; Cortés, H; Del Prado-Audelo, MAL; Figueroa-González, G; Giraldo-Gomez, DM; González-Del Carmen, M; González-Torres, M; Leyva-Gómez, G; Reyes-Hernández, OD; Robles-Kanafany, CM; Sharifi-Rad, J, 2021) |
| "Pain is a common symptom accompanying several clinical conditions and causes serious distress to patients." | ( Cannella, N; Ciccocioppo, R; Guo, Z; Li, H; Qin, D; Shi, F; Wang, Y, 2022) |
| "Pain is similarly reduced for periocular botulinum toxin injections reconstituted with preserved saline compared with unpreserved saline." | ( Hunt, SV; Malhotra, R, 2022) |
| "The pain is associated with ipsilateral autonomic symptoms (most commonly lacrimation, conjunctival injection, nasal congestion or rhinorrhea, ptosis, edema of the eyelid, sweating of the forehead or face, and miosis) and a sense of agitation or restlessness." | ( Bailey, J; Hawks, MK; Malu, OO, 2022) |
| "Pain is a significant concern among older adults with Alzheimer's disease and related dementias (ADRD)." | ( Cheng, Z; Heffner, KL; Kim, Y; Li, Y; Quiñones-Cordero, MM; Wang, J; Yu, F, 2022) |
| "Pain is an integrative phenomenon coupled with dynamic interactions between sensory and contextual processes in the brain, often associated with detectable neurophysiological changes." | ( Chen, D; Guan, C; Kavitha, PT; Loy, FL; Ng, SH; Phua, KS; Tjan, SY; Wang, C; Yang, SY; Zhang, H, 2022) |
| "Pain is a common symptom in patients undergoing cancer treatment." | ( Levoy, K; Meghani, SH; Walker, SL, 2022) |
| "The pain is in part due to irritation of vascular endothelial cells." | ( Chan, P; Chen, CY; Chuang, CM; Leung, YM; Shiao, LR; Wong, KL; Wu, CH; Yen, PS, 2022) |
| "Pain is growing to be a massive health issue across the globe." | ( Lei, F; Yan, Z, 2022) |
| "Pain is also influenced by mesocorticolimbic DA function, but it is not known whether pain or cannabinoid analgesia in adults is altered by early exposure to cannabinoids." | ( Craft, RM; Gogulski, HY, 2022) |
| "Esophageal pain is mediated by sensory nerves, most importantly by the activation of the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor." | ( Alleleyn, AME; Conchillo, JM; Csekő, K; Helyes, Z; Kajtár, B; Keszthelyi, D; Masclee, AAM; Rinsma, NF; Winkens, B, 2022) |
| "In dentistry, pain is a rather inevitable perception that often plagues both the care provider and receiver." | ( Kaarthikeyan, G; Murthykumar, K; Rajasekar, A, 2022) |
| "Dental pain is a common complaint in patients undergoing endodontic treatment." | ( Ramli, R; Sivakumar, D, 2022) |
| "Pain is a significant symptom associated with many musculoskeletal conditions leading to functional impairment and poor quality of life." | ( Hamilton, JA; Lee, KM; Sherlock, JP, 2022) |
| "Pain is the first symptom of acute and chronic inflammation." | ( Almeida, LD; Badenoch, B; Beatriz, A; Cristina Toffoli-Kadri, M; da Silva Gomes, R; da Silva Júnior, EN; da Silveira, IOMF; Fernandes, J; Hortelan, CRW; Janaína de Campos, L; Juliano Oliveira, R; Martins, ACF; Mohammad, J; Moslaves, ISB; Muller, JAI; Okuyama, TT, 2022) |
| "Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual." | ( Abdalla, HB; Basting, RT; Clemente-Napimoga, JT; Napimoga, MH; Trindade da Silva, CA, 2022) |
| "Pain is a global, complex health problem that includes physical, emotional, and social components." | ( Abdel-Fattah, A; Abdel-Monem, AH; Abdelazim, AH; Almrasy, AA; Ramzy, S; Shahin, M, 2022) |
| "Chronic pain is common in older people." | ( Bloomfield, K; Boyd, M; Broad, JB; Calvert, C; Connolly, MJ; Higgins, AM; Hikaka, J; Peri, K; Tatton, A; Wu, Z, 2022) |
| "Pain is commonly reported in people living with myositis." | ( Bhai, S; Bhashyam, A; Filmore, E; Gonzalez Ramos, O; Lubinus, M; Williams, J; Wilson, L, 2022) |
| "Pain is a commonly reported symptom in myositis with variable treatment strategies, including opioid medications." | ( Bhai, S; Bhashyam, A; Filmore, E; Gonzalez Ramos, O; Lubinus, M; Williams, J; Wilson, L, 2022) |
| "Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches." | ( Gable, J; Golovko, MY; Golovko, SA; Gupta, K; Johns, M; Kalyuzhny, AE; Khasabov, SG; Khasabova, IA; Kiven, S; Seybold, VS; Simone, DA, 2023) |
| "Pain is a common symptom that impairs the quality of life for people around the world." | ( Diachkova, E; Grin, M; Korenev, G; Kuznetsov, N; Morozova, N; Noev, A; Pankratov, A; Suvorov, N; Usachev, M; Vasil'ev, Y, 2022) |
| "Pain is a primary driver of action." | ( Coll, MP; Rainville, P; Roy, M; Slimani, H; Vachon-Presseau, É; Wager, TD; Woo, CW, 2022) |
| "Pain is common in hand osteoarthritis (OA) and multiple types may occur." | ( Allaart, CF; Böhringer, S; Boonen, AERCH; Kloppenburg, M; Kortekaas, MC; Kroon, FPB; Niesters, M; Reijnierse, M; Riyazi, N; Rosendaal, FR; Starmans-Kool, M; Turkstra, F; van de Stadt, LA; van der Meulen, C; van Zeben, J, 2022) |
| "Pain is the dominant symptom in hand OA, with an unclear aetiology." | ( Allaart, CF; Böhringer, S; Boonen, AERCH; Kloppenburg, M; Kortekaas, MC; Kroon, FPB; Niesters, M; Reijnierse, M; Riyazi, N; Rosendaal, FR; Starmans-Kool, M; Turkstra, F; van de Stadt, LA; van der Meulen, C; van Zeben, J, 2022) |
| "Itch and pain are both unpleasant, but they are discrete sensations." | ( Kobayashi, K; Noguchi, K; Okubo, M; Saeki, A; Yamanaka, H, 2022) |
| "Pain is the most important symptom in OA, driving medical care, disability, reduced functionality, and decreased quality of life." | ( Arendt Nielsen, L; Beck, C; Hygge Blakeman, K; Liseth Hansen, J; Robinson, R; Rolfson, O; Schepman, P; Wilhelm, S, 2023) |
| "Pain is influenced by various factors, such as fear, anxiety, and memory." | ( Kondo, M; Koyama, Y; Kubo, E; Masui, K; Mitani, O; Nakamura, Y; Okamoto, T; Shimada, S; Sumi, T; Usui, N, 2022) |
| "Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment." | ( Akashi, M; Amano, R; Arimoto, S; Hasegawa, T; Kakei, Y; Kyotani, K; Noda, T; Saito, I; Takeda, D; Yatagai, N, 2022) |
| "Pain is an alarm mechanism to prevent body damage in response to noxious stimuli." | ( Arévalo, JC; Cañada-García, D; Martín-Zanca, D; Sánchez-Sánchez, J; Vicente-García, C, 2023) |
| "Pain is a sensation a humans sense as a protective mechanism against physical injury." | ( Afzal, M; Asaruddin, MR; Khan, MSA; Mahmood, MH; Rahman, HU; Sama, NU, 2022) |
| "Pain is one of the most common concomitant symptoms among cancer patients." | ( Chen, P; Fu, Y; Jia, Y; Li, J; Liu, D; Shou, F; Sun, Y; Wang, Y; Wei, H; Yao, W; Yu, M; Zhang, X; Zheng, R; Zheng, Y; Zhou, J; Zhu, J, 2022) |
| "Procedural pain is a common burden in critical care treatment and the prediction of nociceptive reactions remains challenging." | ( Bublitz, VK; Jurth, C; Lezius, F; Lichtner, G; Schaaf, L; von Dincklage, F; Zimmermann, V, 2022) |
| "This pain is not only distressing to the patient and his or her parents, but often reflects poorly on an otherwise well performed procedure." | ( Opperman, JB; Tshifularo, MI, 2022) |
| "This pain is usually treated with opioids, and most commonly with morphine." | ( Araguz, K; Cunningham, R; Hemphill, A; Hook, MA; Rau, J; Stefanov, A; Weise, L, 2022) |
| "Chronic joint pain is common in patients with osteoarthritis (OA)." | ( Chao, D; Hogan, QH; Pan, B; Tran, H, 2022) |
| "Pain is a major problem in 90% of patients with chronic pancreatitis (CP)." | ( Gopan, A; Jain, SK; Mathias, A; Mishra, P; Poddar, U; Sarma, MS; Srivastava, A; Yachha, SK, 2023) |
| "Pain is one of the most frequent symptoms in cancer patients and has a negative impact on their physical, emotional and functional status, as well as their quality of life (QOL)." | ( Arundorn, T; Dechaphunkul, A; Prisutkul, A; Ruangdam, A; Sathitruangsak, C; Songserm, M, 2022) |
| "Pain is constructed through complex interactions among multiple brain systems, but it remains unclear how functional brain networks are reconfigured over time while experiencing pain." | ( Lee, DH; Lee, JJ; Lee, S; Woo, CW, 2022) |
| "Pain is measured by facial grooming behavior stimulated by capsaicin, the alternation of body weight and food intake was also recorded to reflect the OM pain." | ( Ma, H; Mao, R; Tang, Y; Yan, H; Zhang, Y; Zhao, Y, 2023) |
| "Pain is a major problem that burdens the health and economy of societies worldwide." | ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022) |
| "Although pain is common in osteoarthritis, most people fail to achieve adequate analgesia." | ( Chou, L; Cicuttini, FM; Leaney, AA; Lyttle, JR; Segan, J; Urquhart, DM; Wluka, AE, 2022) |
| "Inflammatory pain is the most important clinical symptom of inflammatory diseases." | ( Chenxi, Z; Hao, Y; Jie, K; Mingpeng, Y; Shiyu, D; Sihan, C; Xiao, T; Xinqiang, Y; Yanlin, Z; Yuanyuan, J; Yumeng, H; Zhipeng, Y, 2022) |
| "Pain is therefore a critical aspect of hemophilia." | ( Buget, MI; Canbolat, N; Dinç, T; Kılıçoğlu, Öİ; Koç, B; Koltka, K; Zulfikar, B, 2022) |
| "Pain is a major non-motor symptom that contributes to impaired quality of life in Parkinson's disease (PD)." | ( Chen, Y; Cheng, O; Cui, J; Li, C; Li, Y; Zhu, D, 2022) |
| "Pain is a private experience, whose assessment relies on subjective self-reporting." | ( Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C, 2022) |
| "Since pain is associated with autonomic arousal, here we used readouts of autonomic activity to assess objectively the arousing effect of somatic stimuli in a human model of hyperalgesia." | ( Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C, 2022) |
| "Acute burn pain is difficult to manage, and poorly managed pain can lead to deleterious consequences such as post-traumatic stress disorder, prolonged recovery, chronic pain and long-term dependence on opioids." | ( Bishop, P; Dedeo, M; Eshraghi, N; Liechty, KL; Ogden, E; Shields, K, 2023) |
| "Pain is a multidimensional construct." | ( Caritis, S; Krans, E; LaSorda, KR; Lim, G; Rosario, BL; Wong, CA, 2023) |
| "Persistent pain is a common and disabling health problem that is often difficult to treat." | ( Blomé, S; Fust, J; Gedin, F; Jensen, K; Lalouni, M; Pontén, M; Raquette, A; Thompson, WH; Vadenmark Lundquist, V, 2022) |
| "Persistent pain is a common and disabling health problem that is often difficult to treat." | ( Blomé, S; Fust, J; Gedin, F; Jensen, K; Lalouni, M; Pontén, M; Raquette, A; Thompson, WH; Vadenmark Lundquist, V, 2022) |
| "BACKGROUNDChronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients." | ( Berger, E; Binshtok, AM; Davidson, E; Edvardson, S; Elpeleg, O; Ghazalin, S; Katz, B; Kfir-Erenfeld, S; Lev, S; Maayan, C; Minke, B; Peters, M; Zaguri, R, 2023) |
| "BACKGROUNDChronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients." | ( Berger, E; Binshtok, AM; Davidson, E; Edvardson, S; Elpeleg, O; Ghazalin, S; Katz, B; Kfir-Erenfeld, S; Lev, S; Maayan, C; Minke, B; Peters, M; Zaguri, R, 2023) |
| "Pain is measured before, during, and after treatment with a visual analog scale (1-10)." | ( Alfaro, K; Alonzo, TA; Bonilla, J; Castle, P; Conzuelo Rodriguez, G; Cremer, M; Felix, JC; Hernández Jovel, DM; Masch, RJ; Murillo, R; Puentes, LO; Qu, X; Soler, M; Sun, J; Wu, S, 2022) |
| "Pain is measured before, during, and after treatment with a visual analog scale (1-10)." | ( Alfaro, K; Alonzo, TA; Bonilla, J; Castle, P; Conzuelo Rodriguez, G; Cremer, M; Felix, JC; Hernández Jovel, DM; Masch, RJ; Murillo, R; Puentes, LO; Qu, X; Soler, M; Sun, J; Wu, S, 2022) |
| "Chronic pain is one of the most critical health issues worldwide." | ( Ballet, S; Cavelier, F; Desgagné, M; Previti, S; Sarret, P; Tourwé, D, 2023) |
| "Pain is the most common presenting symptom in SCD patients with COVID-19." | ( Clarke, K; El Rassi, F; Hall, MAK; McLemore, M; Moussa, M; Shin, YM, 2023) |
| "Pain is one of the major prehospital symptoms in trauma patients and requires prompt management." | ( Albrecht, R; Fischer, H; Grünenfelder, A; Hossfeld, B; Pietsch, U; Rüst, CA; Wenzel, V, 2023) |
| "Inflammatory pain is part of the body's defense mechanism and plays an important role in the healing process." | ( Ben Akacha, A; Ben Ali, R; Ben Othman, A; El May, MV, 2023) |
| "Pain is one of the most frequent causes for patients to seek medical care." | ( Godínez-Chaparro, B; Mendoza-Pérez, F; Pérez-Ramos, J; Santamaria-Anzures, J, 2023) |
| "As pain is an important factor in EM, optimal analgesia should be sought, which to date has been treated primarily with non-steroidal anti-inflammatory drugs (NSAIDs), metamizole or, in extreme cases, opioids." | ( Guan, Q; Mechsner, S; Sehouli, J; Velho, RV, 2023) |
| "Pain is immediate and severe and there are no clear first aid or definitive treatment recommendations." | ( Jackson, A; Little, M; Ryan, F; Young, R, 2023) |
| "Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular." | ( Sun, CK; Tsai, TH, 2023) |
| "Although treating pain is associated with improved quality of life, most respondents did not support TA use in the ED." | ( Anderson-Quiñones, C; Asbell, P; Tolley, EA; Vestal, R; Zhu, R, 2023) |
| "Relief of ongoing pain is a potent motivator of behavior, directing actions to escape from or reduce potentially harmful stimuli." | ( Becker, S; Desch, S; Flor, H; Schweinhardt, P; Seymour, B, 2023) |
| "Cancerrelated pain is often caused by the tumor itself, especially when the tumor is pressing on nerves." | ( Dash, SR; Kundu, CN, 2023) |
| "Nociplastic pain is a severe health problem, while its mechanisms are still unclear." | ( Chen, L; Feng, Z; Li, X; Mei, X; Pan, Y; Wu, C; Yin, C, 2023) |
| "In mammals, pain is regulated by the combination of an ascending stimulating and descending inhibitory pain pathway." | ( Baek, M; Cho, EH; Jang, W; Kim, C; Oh, M, 2023) |
| "Pain is a significant symptom experienced frequently by individuals with sickle cell disease (SCD)." | ( D'Alton, S; Johnson, M; Kanter, J; Phillips, S; Schlenz, AM, 2023) |
| "Although pain is common, significant local tissue injury does not occur." | ( Cue, K; Gilbert, MB; Greene, SC; Khan, R; Rahimi, J, 2023) |
| "Pain is a common manifestation of several benign and malignant conditions." | ( Bauones, S; Cazzato, RL; Dalili, D; Gangi, A; Gantzer, J; Garnon, J; Koch, G; Kurtz, JE, 2023) |
| "Inflammatory pain is induced by trauma, infection, chemical stimulation, etc." | ( Cao, J; Lu, Y; Qin, Z; Tao, T; Wang, H; Zeng, F; Zhao, C; Zheng, H, 2023) |
| "We argue that pain is not needed to protect the body from damage unless the organism is able to make free choices in action selection." | ( Elwood, RW; Farnsworth, KD, 2023) |
| "Pain is the main symptom of osteoarthritis, which severely reduces the patients' quality of life." | ( Ding, JQ; Liu, L; Sun, X; Xie, M; Yang, HY; Yu, LZ; Zhen, SQ; Zhu, HL, 2023) |
| "Management of pain is a component of 80% of all emergency department (ED) visits, and intravenous (IV) opioids are most commonly used to treat moderate to severe pain." | ( Coleska, A; Dinh, D; Oh, A; Parwani, V; Rothenberg, C; Venkatesh, AK, 2023) |
| "Acute corneal pain is a common complaint that causes significant distress to patients and continues to challenge therapeutic avenues for pain management." | ( Courtney, E; Faktorovich, EG; Kelly, MEM; Lafreniere, JD; Szczesniak, AM, 2023) |
| "Pain is a self-reported, dichotomous measure where participants responded to whether they were often troubled with pain and whether this experience interfered with their ability to carry out daily household chores." | ( Ahmed, W; Javed, NB; Maurya, C; Mohanty, P; Muhammad, T; Pai, M, 2023) |
| "Pain is associated with many circumstances, including inflammatory reactions, which arise from modification of the features of signaling pathways." | ( Ling, X; Wang, W, 2023) |
| "Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions." | ( Almeida, JRGS; Baj, T; Batista, MVA; Coutinho, HDM; de Oliveira, MA; Duarte, MC; Guimarães, AG; Kowalska, G; Kowalski, R; Pina, LTS; Quintans, JSS; Quintans-Júnior, LJ; Santos, LABO; Santos, WBR; Serafini, MR; Trindade, GGG, 2023) |
| "Pain is one of the most frequently reported experiences amongst children with Juvenile Idiopathic Arthritis (JIA); however, the management of JIA pain remains challenging." | ( Brandelli, YN; Chambers, CT; Huber, AM; Mackinnon, SP; Parker, JA; Piccolo, O; Stinson, JN; Wildeboer, EM; Wilson, JP, 2023) |
| "Dental pain is a main clinical problem in the elderly population and its assessment and treatment make special challenges for health care services." | ( Aarab, G; Abbasnejad, M; Esmaeili-Mahani, S; Lobbezoo, F; Raoof, M; Torkzadeh-Mahani, S, 2023) |
| "Pain is the main symptom of osteoarthritis (OA) with approximately 50% of patients reporting moderate-to-severe pain." | ( Auer, DP; Cooper, D; Knaggs, R; Kurien, T; Scammell, BE; Walsh, DA; Zedan, Y, 2023) |
| "Joint pain is one of the most debilitating symptoms of rheumatoid arthritis (RA) and patients frequently rate improvements in pain management as their priority." | ( Agalave, NM; Barbier, J; Bersellini Farinotti, A; Eijkelkamp, N; Grönwall, C; Hunt, MA; Jimenéz-Andrade, JM; Jurczak, A; Klareskog, L; Krock, E; Marchand, F; Martinez-Martinez, A; Raoof, R; Rudjito, R; Sandor, K; Simon, N; Svensson, CI; Vazquez-Mora, JA; Wang, Z, 2023) |
| "Pain is the most common cause of office hysteroscopy (OH) failure." | ( Babczyk, D; Baran, R; Gawron, I; Jach, R; Pietrus, M; Zmaczynski, A, 2023) |
| "Pain is a common experience that can range from mild annoyance to debilitating agony." | ( Al-Alsadoon, L; Al-Saffar, M; Taqa, G, 2023) |
| "Upper lateral hip pain is a common complaint in adults and is referred to as greater trochanteric pain syndrome (GTPS) and is more prevalent among older women." | ( Baker, C; Chan, F; Gonzalez, D; Kohan, L; Naeimi, T; Oakes, D; Ortiz, N; Patel, A; Rosenburg, J; Sayed, D; Schulz, J; Schwechter, E; Sitapara, K; Wahezi, SE; Yee, M; Yerra, S; Yih, C, 2023) |
| "Pain is the key symptom of AOM and central to children's and parents' experience of the illness." | ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023) |
| "Cumulative pain is associated with morbidities, including adverse neurodevelopmental outcomes." | ( Shah, PS; Shah, VS; Torgalkar, R, 2023) |
| "The origin of pain is likely neuropathic." | ( Bugayong, ML; DeVita, MA; Shabbir, M, 2023) |
| "Chronic pain is a worldwide refractory health disease that causes major financial and emotional burdens and that is devastating for individuals and society." | ( Acramel, A; Daulhac, L; Jacquot, Y; Jouffre, B; Mallet, C, 2023) |
| "Musculoskeletal pain is a widely experienced public healthcare issue, especially after traumatic muscle injury." | ( Camponogara, C; da Silva, AM; Dalenogare, DP; de Amorim Ferreira, M; de David Antoniazzi, CT; Dos Santos Stein, C; Ferreira, J; Kudsi, SQ; Meira, GM; Moresco, RN; Oliveira, SM; Silveira, PCL; Trevisan, G; Zaccaron, R, 2023) |
| "Pain is one of common symptoms of PD." | ( Ce, Z; Jiren, Z; Pinyuan, Z; Tian, W; Ting, L; Wenbo, Z; Zhigang, M, 2023) |
| "Pain is subjective, so patient-reported experience with pain and analgesia is essential for healthcare professionals." | ( Eppler, F; Häske, D; Heinemann, N; Schempf, B, 2023) |