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tricarboxylic acid

An oxoacid containing three carboxy groups.

ChEBI ID: 27093

Members (26)

MemberDefinitionRole
2-methylcitric acid2-methylcitric acid
2'-deoxymugineic acid2'-deoxymugineic acid
aconitic acidA tricarboxylic acid that is prop-1-ene substituted by carboxy groups at positions 1, 2 and 3.aconitic acid
acromelic acid aA pyrrolidinecarboxylic acid that is siolated from the poisonous mushroom Clitocybe amoenolens.acromelic acid A
aurintricarboxylic acidA member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.aurintricarboxylic acid
bongkrekic acidA tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group. It is produced by the bacterium Burkholderia gladioli and implicated in outbreaks of food-borne illness involving coconut and corn-based products in Indonesia and China.bongkrekic acid
citric acid, anhydrousA tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.citric acid
domoic acidAn L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP).domoic acid
glycyrrhizic acidA triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.glycyrrhizinic acid
homocitric acidhomocitric acid
homoisocitric acidhomoisocitric acid
isocitric acidA tricarboxylic acid that is propan-1-ol with a hydrogen at each of the 3 carbon positions replaced by a carboxy group.isocitric acid
nitrilotriacetic acidnitrilotriacetic acid
nopalineAn amino acid opine resulting from the formal reductive condensation of the amino group of L-arginine with the keto group of 2-oxopentanedioic acid.D-nopaline
pqq cofactorA pyrroloquinoline having oxo groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions.pyrroloquinoline quinone
s-(1,2-dicarboxyethyl)cysteineAn L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a 1,2-dicarboxyethyl group. It is a chemical modification which occurs in tissue proteins and formed by a Michael addition of cysteine to fumaric acid.S-(2-succinyl)-L-cysteine
squalestatin 1A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase.zaragozic acid A
staphyloferrin bA siderophore composed from L-2,3-diaminopropionic acid, citric acid, 1,2-diaminoethane and alpha-ketoglutaric acid units.staphyloferrin B
threo-alpha-methylisocitrateA tricarboxylic acid that is butan-2-ol in which a hydrogen from each of positions 2, 3, and 4 has been replaced by carboxy groups.3-hydroxybutane-1,2,3-tricarboxylic acid
trachyspic acidAn oxaspiro compound that is 1,6-dioxaspiro[4.4]non-2-en-4-one substituted by a carboxymethyl group at position 2, carboxy groups at positions 2 and 3, an oxo group at position 9 and a nonyl group at position 8. Isolated from the culture broth of the fungus Talaromyces trachyspermus, it exhibits inhibitory activity against the enzyme heparanase.trachyspic acid
tricarballylic acidA tricarboxylic acid that is glutaric acid in which one of the beta-hydrogens is substituted by a carboxy group.tricarballylic acid
trimellitic acidBenzene substituted at the 1,2, and 4 positions by carboxy groups.trimellitic acid
trimesic acidA tricarboxylic acid that consists of benzene substituted by carboxy groups at positions 1, 3 and 5.benzene-1,3,5-tricarboxylic acid
tris(2-carboxyethyl)phosphineA tertiary phosphine in which phosphane is substituted with three 2-carboxyethyl groups. It is a commonly used reducing agent.TCEP
vibrioferrinA tricarboxylic acid that is citric acid in which the pro-R carboxy group has been esterified with the primary hydroxy group of 2-hydroxy-1-{(2S)-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}-5-oxoproline. It is a siderophore isolated from bacteria closely associated or symbiotic with toxic, bloom-forming dinoflagellates.vibrioferrin
zaragozic acid cA polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase.zaragozic acid C

Research

Studies (17,923)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19903,448 (19.24)18.7374
1990's3,273 (18.26)18.2507
2000's3,822 (21.32)29.6817
2010's5,373 (29.98)24.3611
2020's2,007 (11.20)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials871 (4.60%)5.53%
Reviews802 (4.23%)6.00%
Case Studies535 (2.82%)4.05%
Observational70 (0.37%)0.25%
Other16,669 (87.98%)84.16%