Page last updated: 2024-08-05 14:58:42

dopamine agonist

A drug that binds to and activates dopamine receptors.

ChEBI ID: 51065

Members (26)

MemberDefinitionClass
7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralinA tertiary amino compound that consists of 2-amino-7-hydroxytetralin in which the two amino hydrogens are substituted by 2E)-3-iodoallyl and propyl groups. This ligand has uniquely high affinity and selectivity for the D3 receptor.2-{[(2E)-3-iodoprop-2-en-1-yl](propyl)amino}tetralin-7-ol
a 77636An isochromene that is 3,4-dihydroisochromene-5,6-diol bearing additional aminomethyl and 1-adamantyl substituents at positions 1 and 3 respectively (the 1R,3S-diastereomer). Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol
a 77636A hydrochloride salt obtained by mixing equimolar amounts of (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol with hydrochloric acid. Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
amantadine hydrochlorideA hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts.amantadine hydrochloride
apomorphineapomorphine
bromocriptinebromocriptine
cabergolineAn N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.cabergoline
carmoxiroleAn indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.carmoxirole
dihydroergotamineErgotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension.dihydroergotamine
fenoldopamfenoldopam
lisuridelisuride
ly 404039An organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models.LY404039
lysergic acid diethylamideAn ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.lysergic acid diethylamide
mesulergineA member of the class of ergot alkaloids that is known to act on serotonin and dopamine receptors.mesulergine
metergolineAn ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.metergoline
mk 458The hydrochloride salt of naxagolide.naxagolide hydrochloride
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromideA hydrobromide salt prepared from N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonising the behavioral effects of cocaine.N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide
naxagolideAn organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued).naxagolide
pergolideA diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.pergolide
pergolide mesylateA methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.pergolide mesylate
pramipexoleA member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.pramipexole
quinpiroleA pyrazoloquinoline that is (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist.quinpirole
ropiniroleropinirole
sk&f 77434A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, an allyl substituent at position 3 and two hydroxy substituents at positions 7 and 8. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol
sk&f 77434A hydrobromide salt prepared from N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide
sk&f 83959A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a 3-methylphenyl substituent at position 1, a methyl substituent at position 3, a chloro substituent at position 6 and two hydroxy substituents at positions 7 and 8. Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonising the behavioral effects of cocaine.N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol

Research

Studies (27,777)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199014,069 (50.65)18.7374
1990's5,587 (20.11)18.2507
2000's4,181 (15.05)29.6817
2010's3,053 (10.99)24.3611
2020's887 (3.19)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,326 (7.27%)5.53%
Reviews2,266 (7.09%)6.00%
Case Studies2,293 (7.17%)4.05%
Observational37 (0.12%)0.25%
Other25,057 (78.35%)84.16%

Protein Targets (297)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency19.731212
15-lipoxygenase, partialHomo sapiens (human)Potency10.000011
67.9K proteinVaccinia virusPotency9.456222
acetylcholinesteraseHomo sapiens (human)Potency29.6578421
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency35.197416
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency31.622811
AR proteinHomo sapiens (human)Potency25.5107721
aryl hydrocarbon receptorHomo sapiens (human)Potency16.373828
arylsulfatase AHomo sapiens (human)Potency21.255414
ATAD5 protein, partialHomo sapiens (human)Potency25.511226
Ataxin-2Homo sapiens (human)Potency21.3452210
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency11.276727
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency13.819826
beta-2 adrenergic receptorHomo sapiens (human)Potency16.360111
Bloom syndrome protein isoform 1Homo sapiens (human)Potency9.103828
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency47.393612
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency33.491511
caspase-3Cricetulus griseus (Chinese hamster)Potency33.491511
caspase-3Homo sapiens (human)Potency33.491511
Caspase-7Cricetulus griseus (Chinese hamster)Potency33.491511
Cellular tumor antigen p53Homo sapiens (human)Potency24.253914
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency19.972227
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency26.081819
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency33.552022
Chain A, Beta-lactamaseEscherichia coli K-12Potency10.041324
Chain A, Ferritin light chainEquus caballus (horse)Potency30.258612
Chain A, HADH2 proteinHomo sapiens (human)Potency12.569422
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency50.118712
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency17.599413
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency24.940413
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency33.723519
Chain B, HADH2 proteinHomo sapiens (human)Potency12.569422
chromobox protein homolog 1Homo sapiens (human)Potency50.7058212
cytochrome P450 2C19 precursorHomo sapiens (human)Potency16.938514
cytochrome P450 2C9 precursorHomo sapiens (human)Potency35.716812
cytochrome P450 2C9, partialHomo sapiens (human)Potency43.113712
cytochrome P450 2D6Homo sapiens (human)Potency7.4020110
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency15.791513
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency13.6804212
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency12.5384210
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency32.277413
D(1A) dopamine receptorHomo sapiens (human)Potency0.9925318
D(1A) dopamine receptorSus scrofa (pig)Potency23.280911
D(3) dopamine receptor isoform eHomo sapiens (human)Potency22.374713
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency29.855411
DNA polymerase betaHomo sapiens (human)Potency50.118711
DNA polymerase eta isoform 1Homo sapiens (human)Potency39.810711
DNA polymerase III, partialBacillus subtilisPotency26.679511
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
DNA polymerase kappa isoform 1Homo sapiens (human)Potency39.985012
dopamine D1 receptorHomo sapiens (human)Potency1.073518
endonuclease IVEscherichia coliPotency25.285512
estrogen nuclear receptor alphaHomo sapiens (human)Potency16.9049927
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency23.710112
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency36.84021023
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency20.1269121
EWS/FLI fusion proteinHomo sapiens (human)Potency19.958144
farnesoid X nuclear receptorHomo sapiens (human)Potency21.998723
flap endonuclease 1Homo sapiens (human)Potency25.008625
Fumarate hydrataseHomo sapiens (human)Potency33.267914
GVesicular stomatitis virusPotency43.113712
GABA theta subunitRattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency13.680316
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency13.680416
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency13.680316
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency13.680316
gemininHomo sapiens (human)Potency17.0201418
GLI family zinc finger 3Homo sapiens (human)Potency26.747528
glp-1 receptor, partialHomo sapiens (human)Potency22.016412
GLS proteinHomo sapiens (human)Potency16.5871215
glucocerebrosidaseHomo sapiens (human)Potency28.796812
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency9.017928
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency20.866212
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency31.373612
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1Homo sapiens (human)Potency25.118911
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency26.121611
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency22.2501212
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency28.183811
histone deacetylase 9 isoform 3Homo sapiens (human)Potency33.491511
Histone H2A.xCricetulus griseus (Chinese hamster)Potency68.916326
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency43.113712
hypothetical protein, conservedTrypanosoma bruceiPotency22.387211
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency26.832511
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency3.981122
IDH1Homo sapiens (human)Potency7.332213
importin subunit beta-1 isoform 1Homo sapiens (human)Potency71.415125
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency43.113714
Integrin alpha-IIbHomo sapiens (human)Potency23.110313
Integrin beta-3Homo sapiens (human)Potency23.110313
Interferon betaHomo sapiens (human)Potency43.113712
lamin isoform A-delta10Homo sapiens (human)Potency16.5577210
lethal factor (plasmid)Bacillus anthracis str. A2012Potency25.118911
LuciferasePhotinus pyralis (common eastern firefly)Potency11.423911
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency40.822733
M-phase phosphoprotein 8Homo sapiens (human)Potency48.389214
Microtubule-associated protein tauHomo sapiens (human)Potency20.6706214
mitogen-activated protein kinase 1Homo sapiens (human)Potency27.285414
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency13.989725
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency29.849636
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency56.234111
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Potency56.234111
neuropeptide S receptor isoform AHomo sapiens (human)Potency31.622811
NFKB1 protein, partialHomo sapiens (human)Potency6.309622
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency7.943311
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency58.047912
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency30.649326
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency30.106511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency21.219727
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency10.000011
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency18.2436310
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency100.000011
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency29.588825
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency19.590414
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency39.418615
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency14.738934
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency14.980323
phosphopantetheinyl transferaseBacillus subtilisPotency50.762317
plasminogen precursorMus musculus (house mouse)Potency5.966512
polyproteinZika virusPotency33.267914
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency8.783413
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency13.324819
pregnane X nuclear receptorHomo sapiens (human)Potency27.525827
progesterone receptorHomo sapiens (human)Potency33.491511
pyruvate kinaseLeishmania mexicana mexicanaPotency12.589322
RAR-related orphan receptor gammaMus musculus (house mouse)Potency21.250524
ras-related protein Rab-9AHomo sapiens (human)Potency101.929012
regulator of G-protein signaling 4Homo sapiens (human)Potency7.574019
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency26.291136
retinoid X nuclear receptor alphaHomo sapiens (human)Potency45.799924
RGS12Homo sapiens (human)Potency25.118911
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency20.290449
SMAD family member 2Homo sapiens (human)Potency8.344612
SMAD family member 3Homo sapiens (human)Potency8.344612
Smad3Homo sapiens (human)Potency35.481311
snurportin-1Homo sapiens (human)Potency71.415125
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency10.974012
survival motor neuron protein isoform dHomo sapiens (human)Potency12.775013
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency22.2632234
thioredoxin glutathione reductaseSchistosoma mansoniPotency29.031012
thioredoxin reductaseRattus norvegicus (Norway rat)Potency14.7909416
ThrombopoietinHomo sapiens (human)Potency10.000024
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency26.3767214
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.008911
thyroid stimulating hormone receptorHomo sapiens (human)Potency40.781149
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency12.962323
transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Potency11.220211
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency10.000011
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency5.966512
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency5.966512
USP1 protein, partialHomo sapiens (human)Potency63.514412
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency20.134023
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency72.547813
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency30.679414
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency20.866212

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)IC500.004111
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC502.551638
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki0.68481215
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.171859
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC502.551638
5-hydroxytryptamine receptor 1BHomo sapiens (human)Ki3.508011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Ki1.617949
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 1DHomo sapiens (human)Ki5.002022
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)Ki0.760022
5-hydroxytryptamine receptor 1EHomo sapiens (human)Ki5.046522
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)Ki0.760022
5-hydroxytryptamine receptor 2AHomo sapiens (human)IC500.012315
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki2.0961812
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Ki0.1390911
5-hydroxytryptamine receptor 2ASus scrofa (pig)Ki0.049011
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC500.017026
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki0.012048
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)Ki0.251646
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC500.170626
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki0.0544510
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Ki0.08151719
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)IC505.096834
5-hydroxytryptamine receptor 3AHomo sapiens (human)Ki10.000011
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)Ki1.500011
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)IC505.096834
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)Ki1.500011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC500.204315
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki0.106915
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)IC505.433834
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)Ki1.500011
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 5AHomo sapiens (human)Ki3.339733
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)Ki1.500011
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)Ki1.500011
5-hydroxytryptamine receptor 6Homo sapiens (human)IC500.020815
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 6Homo sapiens (human)Ki1.0603611
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)Ki1.500011
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)IC5020.800012
5-hydroxytryptamine receptor 7Homo sapiens (human)IC500.205022
5-hydroxytryptamine receptor 7Homo sapiens (human)Ki0.175467
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)IC506.795023
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)Ki0.261278
AcetylcholinesteraseHomo sapiens (human)IC501.344011
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki3.000011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC500.366011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki0.363011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC507.750011
Alpha-1A adrenergic receptorHomo sapiens (human)Ki10.000011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki0.001922
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC507.750011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki0.001922
Alpha-1D adrenergic receptorHomo sapiens (human)IC500.349815
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)IC507.750011
Alpha-1D adrenergic receptorHomo sapiens (human)Ki0.172015
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Ki0.001922
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.067715
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)IC500.206013
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.033826
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)Ki1.300012
Alpha-2B adrenergic receptorHomo sapiens (human)IC500.023915
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)IC500.206013
Alpha-2B adrenergic receptorHomo sapiens (human)Ki0.020426
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Ki1.300012
Alpha-2C adrenergic receptorHomo sapiens (human)IC500.426715
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)IC500.206013
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.060426
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)Ki1.300012
Alpha-synucleinHomo sapiens (human)IC5016.300012
Androgen receptorRattus norvegicus (Norway rat)IC502.281011
Androgen receptorRattus norvegicus (Norway rat)Ki1.521011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000014
ATP-dependent translocase ABCB1Homo sapiens (human)Ki281.677524
ATP-dependent translocase ABCB1Mus musculus (house mouse)Ki503.467524
Beta-1 adrenergic receptorHomo sapiens (human)IC501.479512
Beta-1 adrenergic receptorHomo sapiens (human)Ki0.616323
Beta-2 adrenergic receptorHomo sapiens (human)IC500.041011
Beta-2 adrenergic receptorHomo sapiens (human)Ki42.153845
Beta-3 adrenergic receptorHomo sapiens (human)Ki10.000011
Bile salt export pumpHomo sapiens (human)IC50236.062538
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000014
Catechol O-methyltransferaseRattus norvegicus (Norway rat)Ki0.002511
Cytochrome P450 2D6Homo sapiens (human)IC500.138713
Cytochrome P450 3A4Homo sapiens (human)IC503.249624
DBos taurus (cattle)IC500.27241217
DRattus norvegicus (Norway rat)IC501.55931523
DBos taurus (cattle)Ki13.334623
DMus musculus (house mouse)Ki0.140522
DRattus norvegicus (Norway rat)Ki8.59581112
D(1A) dopamine receptorHomo sapiens (human)IC501.039226
D(1A) dopamine receptorHomo sapiens (human)Ki38.19672031
D(1A) dopamine receptorSus scrofa (pig)Ki0.037022
D(1B) dopamine receptorHomo sapiens (human)IC500.025011
D(1B) dopamine receptorRattus norvegicus (Norway rat)IC500.0843813
D(1B) dopamine receptorHomo sapiens (human)Ki3.451733
D(2) dopamine receptorBos taurus (cattle)IC501.01961321
D(2) dopamine receptorHomo sapiens (human)IC501.277148
D(2) dopamine receptorRattus norvegicus (Norway rat)IC500.15411927
D(2) dopamine receptorBos taurus (cattle)Ki0.855556
D(2) dopamine receptorHomo sapiens (human)Ki0.81887599
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki0.37401921
D(3) dopamine receptorHomo sapiens (human)IC500.007426
D(3) dopamine receptorRattus norvegicus (Norway rat)IC500.0843813
D(3) dopamine receptorHomo sapiens (human)Ki0.03524460
D(3) dopamine receptorRattus norvegicus (Norway rat)Ki0.009867
D(4) dopamine receptorHomo sapiens (human)IC500.025011
D(4) dopamine receptorRattus norvegicus (Norway rat)IC500.0843813
D(4) dopamine receptorHomo sapiens (human)Ki0.03081824
Delta-type opioid receptorHomo sapiens (human)Ki10.000011
E3 ubiquitin-protein ligase Mdm2Homo sapiens (human)IC5010.136733
Endothelin receptor type BHomo sapiens (human)Ki0.007124
Endothelin receptor type BRattus norvegicus (Norway rat)Ki0.007112
Genome polyprotein Zika virusIC5017.320022
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)IC50216.700022
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)IC50216.700022
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)IC50216.700022
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)IC50216.700022
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)IC50216.700022
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)IC50216.700022
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)IC50216.700022
Histamine H1 receptorHomo sapiens (human)IC502.146512
Histamine H1 receptorHomo sapiens (human)Ki0.679723
Histamine H2 receptorHomo sapiens (human)IC501.007512
Histamine H2 receptorHomo sapiens (human)Ki4.617034
Histamine H3 receptorHomo sapiens (human)Ki0.001411
Histamine H4 receptorHomo sapiens (human)Ki10.000011
Lysine-specific demethylase 4EHomo sapiens (human)Ki1.920011
Metabotropic glutamate receptor 2Homo sapiens (human)Ki0.149011
Metabotropic glutamate receptor 3Homo sapiens (human)Ki0.092011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki1.000011
Multidrug and toxin extrusion protein 1Homo sapiens (human)IC502.800011
Multidrug and toxin extrusion protein 2Homo sapiens (human)IC5012.600011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000014
Muscarinic acetylcholine receptor M1Homo sapiens (human)Ki10.000011
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki10.000011
Muscarinic acetylcholine receptor M3Homo sapiens (human)Ki10.000011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC500.120211
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2Ki107.360011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusKi107.360011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC505.192512
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki4.446011
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)Ki0.003211
Sodium-dependent dopamine transporterMacaca fascicularis (crab-eating macaque)Ki0.340011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki0.015034
Sodium-dependent dopamine transporter Homo sapiens (human)IC500.063011
Sodium-dependent dopamine transporter Homo sapiens (human)Ki0.195022
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC500.366011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki0.363011
Sodium-dependent serotonin transporterHomo sapiens (human)IC500.590011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki0.313011
Solute carrier family 22 member 1 Homo sapiens (human)IC5020.800011
Solute carrier family 22 member 2Homo sapiens (human)IC5049.900011
Substance-K receptorHomo sapiens (human)IC504.071011
Substance-K receptorHomo sapiens (human)Ki1.357011
Tryptophan 5-hydroxylase 1Rattus norvegicus (Norway rat)IC500.220011
ubiquitin-conjugating enzyme E2 NHomo sapiens (human)IC5020.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)EC500.009222
5-hydroxytryptamine receptor 1AHomo sapiens (human)Kd0.080212
5-hydroxytryptamine receptor 2AHomo sapiens (human)EC500.151559
5-hydroxytryptamine receptor 2AMus musculus (house mouse)EC5016.113825
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)EC500.009822
5-hydroxytryptamine receptor 2ASus scrofa (pig)EC500.003411
5-hydroxytryptamine receptor 2BHomo sapiens (human)EC500.013011
5-hydroxytryptamine receptor 2CHomo sapiens (human)EC500.609413
Adenosine receptor A2aHomo sapiens (human)EC500.049011
Alpha-1A adrenergic receptorHomo sapiens (human)Kd0.028211
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Kd0.208911
Alpha-1B adrenergic receptorHomo sapiens (human)Kd0.028211
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Kd0.208911
Alpha-1D adrenergic receptorHomo sapiens (human)Kd0.028211
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Kd0.208911
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)Kd0.056211
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Kd0.056211
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)Kd0.056211
DRattus norvegicus (Norway rat)EC500.032622
D(1) dopamine receptorCarassius auratus (goldfish)EC500.008211
D(1A) dopamine receptorHomo sapiens (human)EC501.9591816
D(1A) dopamine receptorHomo sapiens (human)Kd0.354012
D(1B) dopamine receptorHomo sapiens (human)EC500.100012
D(2) dopamine receptorHomo sapiens (human)EC500.26927199
D(2) dopamine receptorRattus norvegicus (Norway rat)EC500.01471214
D(2) dopamine receptorHomo sapiens (human)Kd0.008033
D(2) dopamine receptorRattus norvegicus (Norway rat)Kd1.3499430
D(3) dopamine receptorHomo sapiens (human)EC500.01403443
D(3) dopamine receptorRattus norvegicus (Norway rat)EC500.032435
D(3) dopamine receptorHomo sapiens (human)Kd0.000011
D(3) dopamine receptorRattus norvegicus (Norway rat)Kd0.000111
D(4) dopamine receptorHomo sapiens (human)EC500.02852022
D(4) dopamine receptorRattus norvegicus (Norway rat)EC500.004233
Dipeptidyl peptidase 4Homo sapiens (human)EC500.023012
Dipeptidyl peptidase 4Mus musculus (house mouse)EC500.003411
Genome polyprotein Zika virusEC5013.020022
heat shock protein 90Candida albicansEC503.364011
HeparanaseHomo sapiens (human)Kd1,000.000011
Histamine H1 receptorHomo sapiens (human)Kd0.004511
Histamine H2 receptorHomo sapiens (human)EC500.166011
Histamine H2 receptorHomo sapiens (human)Kd0.012211
Histamine H4 receptorHomo sapiens (human)Kd0.016011
Metabotropic glutamate receptor 2Homo sapiens (human)EC500.023411
Metabotropic glutamate receptor 3Homo sapiens (human)EC500.048011
Metabotropic glutamate receptor 5Homo sapiens (human)EC500.001911
Metabotropic glutamate receptor 8Homo sapiens (human)EC5047.773011
Mu-type opioid receptorCavia porcellus (domestic guinea pig)EC500.051011
mu-type opioid receptor isoform MOR-1Homo sapiens (human)EC5092.455726
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)EC500.001714

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)Activity0.010011
5-hydroxytryptamine receptor 1BHomo sapiens (human)Activity0.028011
5-hydroxytryptamine receptor 1DHomo sapiens (human)Activity0.000911
5-hydroxytryptamine receptor 1EHomo sapiens (human)Activity1.659011
5-hydroxytryptamine receptor 2AHomo sapiens (human)Activity0.007111
5-hydroxytryptamine receptor 2BHomo sapiens (human)Activity0.002611
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Activity0.009511
5-hydroxytryptamine receptor 3AHomo sapiens (human)Activity10.000011
5-hydroxytryptamine receptor 4Homo sapiens (human)Activity1.274011
5-hydroxytryptamine receptor 5AHomo sapiens (human)Activity0.562011
5-hydroxytryptamine receptor 6Homo sapiens (human)Activity0.091011
5-hydroxytryptamine receptor 7Homo sapiens (human)Activity0.018011
5-hydroxytryptamine receptor 7Homo sapiens (human)Kb0.011011
5-hydroxytryptamine receptor 7Homo sapiens (human)Kbapp0.016011
Alpha-1A adrenergic receptorHomo sapiens (human)Activity0.030011
Alpha-1B adrenergic receptorHomo sapiens (human)Activity0.123011
Alpha-1D adrenergic receptorHomo sapiens (human)Activity0.091011
Alpha-2A adrenergic receptorHomo sapiens (human)Activity0.031011
Alpha-2B adrenergic receptorHomo sapiens (human)Activity0.041011
Alpha-2C adrenergic receptorHomo sapiens (human)Activity0.030011
DRattus norvegicus (Norway rat)K 0.55.000011
DRattus norvegicus (Norway rat)KL0.021011
D(1A) dopamine receptorHomo sapiens (human)Activity0.009011
D(1A) dopamine receptorHomo sapiens (human)ID500.039011
D(1A) dopamine receptorHomo sapiens (human)KL0.206011
D(1B) dopamine receptorHomo sapiens (human)ID500.039011
D(2) dopamine receptorHomo sapiens (human)Activity0.074011
D(2) dopamine receptorHomo sapiens (human)ID500.039011
D(2) dopamine receptorRattus norvegicus (Norway rat)Intrinsic activity0.095011
D(2) dopamine receptorRattus norvegicus (Norway rat)K 0.51.139422
D(2) dopamine receptorHomo sapiens (human)KL0.166522
D(2) dopamine receptorRattus norvegicus (Norway rat)KL1.000011
D(3) dopamine receptorRattus norvegicus (Norway rat)Activity5.007022
D(3) dopamine receptorHomo sapiens (human)ED500.003711
D(3) dopamine receptorHomo sapiens (human)ID500.039011
D(3) dopamine receptorRattus norvegicus (Norway rat)K 0.50.004511
D(4) dopamine receptorHomo sapiens (human)Activity0.004911
D(4) dopamine receptorHomo sapiens (human)ID500.039011
D(4) dopamine receptorHomo sapiens (human)Intrinsic activity0.100011
Delta-type opioid receptorHomo sapiens (human)Activity0.018911
Histamine H1 receptorHomo sapiens (human)Activity0.098211
Histamine H2 receptorHomo sapiens (human)Activity0.104011
Histamine H4 receptorHomo sapiens (human)Activity0.012711
interferon gamma precursorHomo sapiens (human)AC5039.000011
Kappa-type opioid receptorRattus norvegicus (Norway rat)Activity0.063211
Muscarinic acetylcholine receptor M1Homo sapiens (human)Activity0.001211
Muscarinic acetylcholine receptor M2Homo sapiens (human)Activity0.017711
Muscarinic acetylcholine receptor M3Homo sapiens (human)Activity0.003811
Muscarinic acetylcholine receptor M4Homo sapiens (human)Activity0.036911
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)Activity0.021711
Prostaglandin E2 receptor EP4 subtypeHomo sapiens (human)Activity0.015211
Sodium-dependent noradrenaline transporter Homo sapiens (human)Activity1.132011
Sodium-dependent serotonin transporterHomo sapiens (human)Activity0.089711
Solute carrier family 22 member 1Rattus norvegicus (Norway rat)Km30.000022
Solute carrier family 22 member 2Rattus norvegicus (Norway rat)Km17.000022