Page last updated: 2024-09-27

Eosinophilic Esophagitis

Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.

Synonyms(1)

Synonym
Eosinophilic Esophagitis

Research Excerpts

Overview

ExcerptReference
"Eosinophilic esophagitis is characterized by dense infiltration of the esophageal epithelium with eosinophils, typically accompanied by dysphagia."( Al-Zubeidi, D; Guerin, L; Mitros, F; Rahhal, R; Stumphy, J, 2011)
"Eosinophilic esophagitis is a clinicopathologic disease that can present with a constellation of upper gastrointestinal symptoms and endoscopic findings in conjunction with significant infiltration of the esophageal tissue with eosinophils."( Chehade, M; Lieberman, JA, 2012)
"Eosinophilic esophagitis is increasingly recognized as a cause of dysphagia, and food impaction is often the presenting symptom."( Grim, R; Oosterveen, S; Thimmapuram, J, 2013)
"Eosinophilic esophagitis is characterized by eosinophil-predominant inflammation in the esophagus."( Wu, X; Yu, S; Zhang, S, 2014)
"Eosinophilic esophagitis is characterized by destructive responses of the immune system to environmental allergens, including food, on the human esophagus."( Hakonarson, H; March, M; Sleiman, PMA, 2015)
"Eosinophilic esophagitis is a manifestation of non-IgE-mediated food allergy that most commonly affects the esophagus of males who have other atopic phenomena."( Putnam, PE, 2016)
"Eosinophilic esophagitis is a chronic immunogenic-antigen mediated disease of the esophagus, characterized by symptoms related to esophagus dysfunction, histologically defined by over 15 eosinophil counts seen in high-power microscopic field, without gastroesophageal reflux disease."( Damjanov, D; Jocić, T; Krnetić, Ž; Savić, Ž; Vračarić, V; Živojinov, M, 2017)
"Current eosinophilic esophagitis care requires monitoring with repeat endoscopy and biopsy, which has significant cost, risk, and inconvenience for patients."( Alexander, J; Geno, D; Iyer, V; Johnson, K; Katzka, D; Lennon, R; Pendegraft, R; Ravi, K, 2019)
"Eosinophilic esophagitis is identified by eosinophilic infiltration confirmed on a pathological examination."( Jung, KW; Kim, GH, 2019)

Treatment

ExcerptReference
"Current treatments of eosinophilic esophagitis (EoE), including restrictive diets or glucocorticoids, provide only transient improvement."( Edelman, M; Lai, J; Levine, J; Schuval, SJ, 2012)
"Although most studies on treatments for eosinophilic esophagitis (EoE) have focused on effects in the epithelium, EoE is a transmural disease."( Cheng, E; Huo, X; Park, JY; Souza, RF; Spechler, SJ; Wang, DH; Wilson, KS; Yu, C; Zhang, Q; Zhang, X, 2016)
"Although effective in the treatment of eosinophilic esophagitis (EoE) in children, limited data exist on long-term safety and efficacy of swallowed topical corticosteroids."( Andreae, DA; Andreae, MH; Bagiella, E; Chehade, M; Hanna, MG; Magid, MS; Malerba, S, 2016)
"Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery."( Collins, MH; Dellon, ES; Gupta, SK; Hamdani, M; Hirano, I; Katzka, DA, 2017)
"Topical steroid treatments for eosinophilic esophagitis (EoE) include swallowed fluticasone from a multi-dose inhaler (MDI) or oral viscous budesonide (OVB) slurry, but the 2 have never been compared."( Arrington, A; Baron, JA; Covington, J; Dellon, ES; Galanko, JA; Gebhart, JH; Martin, CF; McGee, SJ; Moist, SE; Shaheen, NJ; Shoyoye, SO; Tylicki, AE; Woosley, JT, 2019)
"No approved medication exists for the treatment of eosinophilic esophagitis (EoE) in the United States, which forces patients to utilize off-label drugs and/or create their own formulations."( Dellon, ES; Ketchem, CJ; Reed, CC; Stefanadis, Z, 2021)
"Mometasone-furoate for Treatment of Eosinophilic Esophagitis - a Randomized Placebo Controlled Study ClinicalTrials."( Bergquist, H; Bove, M; Johansson, L; Larsson, H; Tytor, J, 2021)
"Topical steroids are effective treatments for eosinophilic esophagitis (EoE)."( Comer, GM; Dellon, ES; Eagle, G; Falk, GW; Hirano, I; Knoop, K; Lucendo, AJ; Nezamis, J; Schlag, C; Schoepfer, AM, 2022)
"Topical steroids are commonly used in treatment of eosinophilic esophagitis (EoE), but currently there is lack of data to clarify most effective regimen."( Akambase, JA; Alexander, JA; Geno, D; Johnson, K; Katzka, DA; Lavey, C; Lennon, RJ; Ravi, K; Schupack, DA; Snyder, DL, 2022)

Research

Studies (302)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's225 (74.50)28.8240
2020's77 (25.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrochloric acid0low10
histamine0low10
spermine0low10
2-aminoethoxydiphenyl borate0low10
acetaminophen0low10
albuterol0low10
aspirin0low40
caffeine0low10
verapamil0low10
chloroquine0low10
gabapentin0low10
guaifenesin0low10
hydroxyurea0low10
ketotifen0low10
leflunomide0low10
methyl salicylate0low10
omeprazole0medium192
pantoprazole0low10
pioglitazone0low10
propofol0low20
rabeprazole0low40
prednisolone0low40
prednisone0low40
alanine0low10
allyl isothiocyanate0low10
sucrose0low20
tyrosine0low10
egtazic acid0low10
mannitol0low10
phencyclidine0low10
methylprednisolone0low10
pyrroles0low40
isoxazoles0low10
hydantoins0low10
chenodeoxycholic acid0low10
hematoxylin0low10
eosine yellowish-(ys)0low10
dehydroepiandrosterone sulfate0low10
fluorescein-5-isothiocyanate0low20
technetium0low10
argon0low10
acetylglucosamine0low10
barium sulfate0low40
cromolyn sodium0medium21
phenyl acetate0medium51
triamcinolone0low10
diltiazem0low10
salmeterol xinafoate0low10
emtricitabine0low10
trazodone hydrochloride0low50
plerixafor0medium11
fluorodeoxyglucose f180low10
trichlorosucrose0low10
alafosfalin0low10
rosiglitazone0low10
bw 245c0low10
allosamidin0low10
egta acetoxymethyl ester0low10
bw a868c0low10
galactosyl-(1-3)galactose0low10
ramatroban0low10
3-bromotyrosine0low10
deflazacort0low10
abacavir0low10
tacrolimus0low10
prostaglandin d20low10
tenofovir0low10
bromochloroacetic acid0medium21
(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide0low10
cotinine0low10
capsaicin0low10
oxazolone0low10
ranitidine0low10
ovalbumin0low100
myelin basic protein0low10
leukotriene a40low10
leukotriene c40low10
alprostadil0low10
dexmedetomidine0low10
fluticasone0medium8214
ono-ae1-3290low10
15-hydroxy-5,8,11,13-eicosatetraenoic acid0low10
barium0low20
involucrin0low10
ciclesonide0low30
chlorhexidine0medium11
s 17430medium84
dexlansoprazole0medium11
tofacitinib0low10
aluminum oxide0low10
fidaxomicin0low10
lactulose0low10
butaprost0low10
vonoprazan0low30
glucagon0low10
calpain0low140
egg white0low10
incb-0184240low10
piperidines0low10
interleukin-80low20
ascorbic acid0low10
dolutegravir0low10
fluticasone propionate, salmeterol xinafoate drug combination0low10
transforming growth factor beta0medium61
rome0medium11
angiogenin0low10

Protein Targets (1,282)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Ferritin light chain5005
ATAD5 protein, partial7007
USP1 protein, partial170017
Microtubule-associated protein tau7007
thyroid stimulating hormone receptor160016
estrogen-related nuclear receptor alpha290029
glucocerebrosidase8008
atrial natriuretic peptide receptor 1 precursor3003
chromobox protein homolog 1150015
mitogen-activated protein kinase 16006
atrial natriuretic peptide receptor 2 precursor4004
ras-related protein Rab-9A4004
serine/threonine-protein kinase mTOR isoform 12002
nuclear receptor ROR-gamma isoform 1120012
DNA polymerase kappa isoform 16006
survival motor neuron protein isoform d8008
lethal factor (plasmid)7007
Transient receptor potential cation channel subfamily V member 10314
Alpha-synuclein3003
Transient receptor potential cation channel subfamily V member 10349
Ataxin-2140014
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, 2-oxoglutarate Oxygenase9009
Chain A, Cruzipain3003
15-lipoxygenase, partial7007
phosphopantetheinyl transferase100010
TDP1 protein260026
aldehyde dehydrogenase 1 family, member A1160016
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1100010
vitamin D3 receptor isoform VDRA8008
thyroid hormone receptor beta isoform a4004
cytochrome P450 3A4 isoform 1190019
histone acetyltransferase KAT2A isoform 1100010
Gamma-aminobutyric acid receptor subunit pi191121
Polyunsaturated fatty acid lipoxygenase ALOX15B9009
Transient receptor potential cation channel subfamily M member 20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Gamma-aminobutyric acid receptor subunit beta-1191121
Gamma-aminobutyric acid receptor subunit delta191121
Gamma-aminobutyric acid receptor subunit gamma-2191121
Gamma-aminobutyric acid receptor subunit alpha-5191121
Gamma-aminobutyric acid receptor subunit alpha-3191121
Gamma-aminobutyric acid receptor subunit gamma-1191121
Gamma-aminobutyric acid receptor subunit alpha-2191121
Gamma-aminobutyric acid receptor subunit alpha-4191121
Gamma-aminobutyric acid receptor subunit gamma-3191121
Gamma-aminobutyric acid receptor subunit alpha-6191121
Histamine H2 receptor110112
Gamma-aminobutyric acid receptor subunit alpha-1192122
Gamma-aminobutyric acid receptor subunit beta-3191121
Gamma-aminobutyric acid receptor subunit beta-2191121
Transient receptor potential cation channel subfamily V member 30001
GABA theta subunit191121
Gamma-aminobutyric acid receptor subunit epsilon191121
Transient receptor potential cation channel subfamily V member 20001
Luciferase100010
cytochrome P450 family 3 subfamily A polypeptide 4240024
cytochrome P450 2D6150015
euchromatic histone-lysine N-methyltransferase 2290029
peripheral myelin protein 22140014
Albumin0033
ATP-dependent translocase ABCB108116
Replicase polyprotein 1ab0415
Replicase polyprotein 1ab0617
Reverse transcriptase/RNaseH 0327
Broad substrate specificity ATP-binding cassette transporter ABCG2010111
RAR-related orphan receptor gamma230023
GLS protein140014
Smad33003
nuclear receptor subfamily 1, group I, member 3170017
progesterone receptor200020
EWS/FLI fusion protein190019
retinoic acid nuclear receptor alpha variant 1200020
retinoid X nuclear receptor alpha180018
estrogen nuclear receptor alpha400040
peroxisome proliferator activated receptor gamma140014
aryl hydrocarbon receptor120012
thyroid hormone receptor beta isoform 2230023
ATP-binding cassette sub-family C member 3025025
Multidrug resistance-associated protein 4026028
Solute carrier family 22 member 60202
Carbonic anhydrase 120204
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0606
Voltage-dependent calcium channel gamma-2 subunit9009
Bile salt export pump033033
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 108011
Carbonic anhydrase 2013119
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20506
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30204
Cytochrome P450 3A4013115
Cytochrome P450 2D60606
Cytochrome P450 2C9 010111
Polyunsaturated fatty acid lipoxygenase ALOX150202
Sulfotransferase 1A1 0001
UDP-glucuronosyltransferase 1-60102
Glutamate receptor 29009
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0204
Carbonic anhydrase 40406
Prostaglandin G/H synthase 10505
Carbonic anhydrase 60305
Carbonic anhydrase 5A, mitochondrial0406
Prostaglandin G/H synthase 20326
Carbonic anhydrase 70305
Nuclear receptor ROR-gamma6006
Cytochrome P450 2J20707
Carbonic anhydrase 906110
Canalicular multispecific organic anion transporter 1023023
Carbonic anhydrase 150204
Carbonic anhydrase 130304
Carbonic anhydrase 140204
Carbonic anhydrase 5B, mitochondrial0305
toxin B0001
Putative glycosyltransferase WbgO0001
Cannabinoid receptor 10202
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0428
Proton-coupled amino acid transporter 10101
Adenosine deaminase0001
Carbonic anhydrase 40002
glp-1 receptor, partial8008
thioredoxin reductase140014
regulator of G-protein signaling 4120012
NPYLR7B0011
arylsulfatase A5005
thyroid stimulating hormone receptor6006
flap endonuclease 17007
Beta-2 adrenergic receptor0426
Beta-1 adrenergic receptor0022
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Beta-3 adrenergic receptor0213
Delta-type opioid receptor0011
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
Beta-2 adrenergic receptor 0013
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Beta-2 adrenergic receptor0123
ATP-dependent phosphofructokinase120012
Chitinase B0101
Endochitinase0101
Endochitinase A10101
Acidic mammalian chitinase0101
acetylcholinesterase100010
AR protein340034
farnesoid X nuclear receptor9009
pregnane X nuclear receptor240024
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a190019
nuclear factor erythroid 2-related factor 2 isoform 1210021
Transient receptor potential cation channel subfamily A member 10012
Macrophage migration inhibitory factor0303
Tyrosine-protein kinase JAK105512
Non-receptor tyrosine-protein kinase TYK205512
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily A member 10011
Transient receptor potential cation channel subfamily M member 80011
glucocorticoid receptor [Homo sapiens]240024
Cellular tumor antigen p53150015
Thromboxane-A synthase 0303
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0213
Nuclear receptor subfamily 4 group A member 20022
Solute carrier organic anion transporter family member 2A10102
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier organic anion transporter family member 2A10103
Solute carrier organic anion transporter family member 2B10102
Solute carrier organic anion transporter family member 3A10001
Chain A, Hyaluronidase, phage associated0101
GLI family zinc finger 3210021
thioredoxin glutathione reductase5005
vitamin D (1,25- dihydroxyvitamin D3) receptor140014
IDH17007
nuclear factor erythroid 2-related factor 2 isoform 28008
lethal(3)malignant brain tumor-like protein 1 isoform I3003
geminin170017
lamin isoform A-delta10200020
Polyphenol oxidase 20102
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0527
Spike glycoprotein121114
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein140014
Chain B, HADH2 protein140014
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
hypothetical protein, conserved2002
peroxisome proliferator-activated receptor delta100010
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 19009
DNA polymerase iota isoform a (long)100010
muscarinic acetylcholine receptor M1100010
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0325
Fatty acid-binding protein, liver0202
Integrin beta-34105
Myeloperoxidase0101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb4105
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10306
Adenosine receptor A2a0307
Substance-P receptor0101
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10314
Sigma non-opioid intracellular receptor 10213
Chain A, Beta-lactamase5005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
muscleblind-like protein 1 isoform 14004
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
v-jun sarcoma virus 17 oncogene homolog (avian)140014
DNA polymerase beta3003
Potassium channel subfamily K member 20011
Glycogen phosphorylase, muscle form0202
Renin0101
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Adenosine receptor A30505
Amine oxidase [flavin-containing] A0404
Acetylcholinesterase0202
Amine oxidase [flavin-containing] B0606
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0325
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0123
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0112
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0102
Phosphodiesterase 0101
Guanine deaminase0101
estrogen receptor 2 (ER beta)110011
67.9K protein6006
transient receptor potential cation channel subfamily V member 12002
Lysine-specific histone demethylase 1A0101
NADH-ubiquinone oxidoreductase chain 10101
Polyunsaturated fatty acid 5-lipoxygenase0303
Cannabinoid receptor 10101
Cannabinoid receptor 2 0101
D(2) dopamine receptor0112
Inositol monophosphatase 14004
Potassium voltage-gated channel subfamily A member 10202
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 40011
Transient receptor potential cation channel subfamily V member 20011
Histamine H1 receptor0527
Angiopoietin-1 receptor0033
Potassium voltage-gated channel subfamily H member 20606
Multidrug and toxin extrusion protein 10303
Histamine H4 receptor0325
SMAD family member 27007
SMAD family member 37007
caspase 7, apoptosis-related cysteine protease5005
caspase-35005
Caspase-72002
caspase-32002
Alpha-2A adrenergic receptor08210
Vitamin D3 receptor0112
Alpha-2C adrenergic receptor0426
Retinoic acid receptor RXR-alpha0011
Guanine nucleotide-binding protein G2002
Ileal sodium/bile acid cotransporter0101
TAR DNA-binding protein 433003
Bile acid receptor0011
G-protein coupled bile acid receptor 10022
Bile acid receptor0011
Chain A, JmjC domain-containing histone demethylation protein 3A5005
Chain A, BCL-2-RELATED PROTEIN A10011
acid sphingomyelinase2002
PAX80001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit8008
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)8008
PINK11001
G120012
Parkin3003
heat shock protein 900011
calcineurin A1, putative0011
activating transcription factor 69009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
Histone H2A.x4004
cytochrome P450 2D6 isoform 14004
hepatocyte nuclear factor 4-alpha isoform 20202
cellular tumor antigen p53 isoform a5005
cytochrome P450 2C19 precursor8008
cytochrome P450 2C9 precursor4004
perilipin-50202
perilipin-10202
potassium voltage-gated channel subfamily H member 2 isoform d100010
transcriptional regulator ERG isoform 32002
heat shock protein beta-18008
huntingtin isoform 25005
importin subunit beta-1 isoform 11001
ubiquitin-conjugating enzyme E2 N0101
nuclear factor NF-kappa-B p105 subunit isoform 11001
protein AF-9 isoform a0001
snurportin-11001
melanocortin receptor 40101
CAAX prenyl protease0001
bcl-2-related protein A10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0202
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0001
bcl-2-like protein 11 isoform 10011
Synaptojanin-20101
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0506
Synaptojanin-10101
Solute carrier family 22 member 30304
Glutathione reductase, mitochondrial0203
Interferon beta180018
HLA class I histocompatibility antigen, B alpha chain 120012
72 kDa type IV collagenase0101
Matrix metalloproteinase-90202
Trypanothione reductase0101
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Multidrug and toxin extrusion protein 20202
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 1120012
ATPase family AAA domain-containing protein 58008
Spermine oxidase0101
cytochrome P450 2C9, partial120012
PPM1D protein6006
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0202
Spike glycoprotein0112
Replicase polyprotein 1ab0213
glucose-6-phosphate 1-dehydrogenase isoform b0202
Transmembrane protease serine 20112
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein1102
Histidine-rich protein PFHRP-II0102
Procathepsin L0112
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M50303
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Muscarinic acetylcholine receptor M10505
Ribosyldihydronicotinamide dehydrogenase [quinone]0123
DNA ligase 10101
Muscarinic acetylcholine receptor M30505
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
nuclear receptor subfamily 1, group I, member 28008
GALC protein3003
Neuronal acetylcholine receptor subunit alpha-41113
Cytochrome P450 2A60303
Neuronal acetylcholine receptor subunit beta-21113
Cytochrome P450 2A50101
Alkaline phosphatase, germ cell type0101
G protein-coupled receptor GPR350011
G-protein coupled receptor 350011
G-protein coupled receptor 350011
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Steryl-sulfatase0102
Multidrug resistance-associated protein 1 0215
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30304
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10607
WD repeat-containing protein 50404
Histone-lysine N-methyltransferase 2A0404
NAD(+) hydrolase SARM10202
Cytosolic endo-beta-N-acetylglucosaminidase0404
Alpha-1B adrenergic receptor 0011
Alpha-1B adrenergic receptor0505
Alpha-1A adrenergic receptor0011
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Alpha-1D adrenergic receptor0303
Alpha-1A adrenergic receptor0505
D(1A) dopamine receptor5005
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1D0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
5-hydroxytryptamine receptor 70202
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Chain A, PFV integrase0101
Chain A, PFV integrase0101
Chain A, PFV integrase0101
Fumarate hydratase6006
polyprotein6006
Cytochrome P450 2C80404
Cytochrome P450 2C190405
Integrase 0011
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10101
Vesicular acetylcholine transporter0101
Integrase 0112
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
endonuclease IV1001
peripheral myelin protein 22 isoform 16006
thyrotropin-releasing hormone receptor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Asialoglycoprotein receptor 10112
Rap guanine nucleotide exchange factor 32002
Chain E, Fibrin beta chain0101
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, RNA-directed RNA polymerase NS50101
WRN1001
Mcl-10202
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
alkaline phosphatase, intestinal0011
apical membrane antigen 1, AMA14004
luciferase1001
bromodomain adjacent to zinc finger domain 2B6006
pyruvate kinase2002
CDK50001
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein3003
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
intestinal alkaline phosphatase precursor0011
serine/threonine-protein kinase PLK13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Pyruvate kinase PKM0101
Endothelin receptor type B2002
Endothelin-1 receptor2002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
transforming acidic coiled-coil-containing protein 30001
Plasma kallikrein0002
Histamine H2 receptor0527
Histamine H1 receptor0134
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase0103
Carbonic anhydrase0003
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0305
Glutamate receptor ionotropic, NMDA 2B0417
Glutamate receptor ionotropic, NMDA 2C0306
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0104
Carbonic anhydrase0003
Glutamate receptor ionotropic, NMDA 2D0305
Solute carrier family 22 member 10102
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0305
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0305
Histamine H3 receptor0123
Glycogen synthase kinase-3 alpha0123
Glycogen synthase kinase-3 beta0224
Protein cereblon0202
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
NFKB1 protein, partial5005
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10213
Urease subunit alpha0202
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20213
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Gamma-aminobutyric acid receptor subunit alpha-40112
Urease subunit beta0202
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Leukotriene C4 synthase0022
tyrosine-protein kinase Yes3003
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0022
Serine/threonine-protein kinase PLK40022
Serine/threonine-protein kinase 250022
ATP-dependent RNA helicase DDX3X0022
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase RIO30022
Dual specificity mitogen-activated protein kinase kinase 70123
Serine/threonine-protein kinase Chk10123
Inhibitor of nuclear factor kappa-B kinase subunit beta0022
Peripheral plasma membrane protein CASK0022
Aurora kinase A0022
Cyclin-G-associated kinase0123
Serine/threonine-protein kinase DCLK10022
Inhibitor of nuclear factor kappa-B kinase subunit alpha0022
Muscle, skeletal receptor tyrosine-protein kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Mitogen-activated protein kinase 130123
3-phosphoinositide-dependent protein kinase 10022
Mitogen-activated protein kinase kinase kinase 130022
Death-associated protein kinase 30022
Mitogen-activated protein kinase kinase kinase 70022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
NUAK family SNF1-like kinase 10022
Dynamin-like 120 kDa protein, mitochondrial0022
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0022
Tyrosine-protein kinase JAK205411
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20123
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50123
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0022
Serine/threonine-protein kinase PAK 30022
Cyclin-dependent kinase-like 50022
Serine/threonine-protein kinase 17B0022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Cyclin-dependent kinase 140022
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60022
Serine/threonine-protein kinase OSR10022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Serine/threonine-protein kinase Chk20022
Tyrosine-protein kinase ABL10022
RAF proto-oncogene serine/threonine-protein kinase0022
Receptor tyrosine-protein kinase erbB-20123
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Protein kinase C beta type0022
Insulin receptor0123
Tyrosine-protein kinase Lck0123
Tyrosine-protein kinase Fyn0123
Cyclin-dependent kinase 10022
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Macrophage colony-stimulating factor 1 receptor0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Proto-oncogene tyrosine-protein kinase ROS0022
Platelet-derived growth factor receptor beta0022
Tyrosine-protein kinase Fgr0022
Wee1-like protein kinase 20022
Uncharacterized serine/threonine-protein kinase SBK30022
Serine/threonine-protein kinase A-Raf0022
Mast/stem cell growth factor receptor Kit0022
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Insulin receptor-related protein0022
Serine/threonine-protein kinase B-raf0022
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Platelet-derived growth factor receptor alpha0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0123
cAMP-dependent protein kinase catalytic subunit alpha0022
Vascular endothelial growth factor receptor 1 0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Interferon-induced, double-stranded RNA-activated protein kinase0022
Casein kinase II subunit alpha'0022
Serine/threonine-protein kinase MAK0022
Cyclin-dependent kinase 11B0022
Ephrin type-A receptor 10022
Fibroblast growth factor receptor 20022
Receptor tyrosine-protein kinase erbB-30022
Multifunctional protein ADE20022
Fibroblast growth factor receptor 40022
Fibroblast growth factor receptor 30022
cAMP-dependent protein kinase catalytic subunit gamma0022
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10123
Protein kinase C eta type0022
Cyclin-dependent kinase 20123
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Activin receptor type-2A0022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20022
Ephrin type-A receptor 30022
Ephrin type-A receptor 80022
Ephrin type-B receptor 20022
Leukocyte tyrosine kinase receptor0022
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0022
Heme oxygenase 20022
Tyrosine-protein kinase receptor UFO0022
Mitogen-activated protein kinase 40022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0123
RAC-beta serine/threonine-protein kinase0022
G protein-coupled receptor kinase 40022
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40011
Myosin-100011
Tyrosine-protein kinase receptor Tie-10022
Vascular endothelial growth factor receptor 30022
Vascular endothelial growth factor receptor 20022
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
Serine/threonine-protein kinase receptor R30022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0123
Glycine--tRNA ligase0022
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0123
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0022
Megakaryocyte-associated tyrosine-protein kinase0022
Tyrosine-protein kinase Tec0123
Tyrosine-protein kinase TXK0123
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
Tyrosine-protein kinase ZAP-700022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80123
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 40022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha1012
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20123
Cyclin-dependent kinase 80022
Elongation factor Tu, mitochondrial0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0011
Tyrosine-protein kinase Blk0123
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30123
Cytoplasmic tyrosine-protein kinase BMX0123
cAMP-dependent protein kinase catalytic subunit PRKX0022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Serine/threonine-protein kinase Nek40022
Tyrosine-protein kinase JAK305311
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
Death-associated protein kinase 10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 120123
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
5'-AMP-activated protein kinase catalytic subunit alpha-20022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-B receptor 10022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0023
Oxysterols receptor LXR-beta0101
Adenosine kinase0022
Hormonally up-regulated neu tumor-associated kinase0022
Serine/threonine-protein kinase SIK10022
Receptor-interacting serine/threonine-protein kinase 40022
Ras-related protein Rab-100022
Cell division control protein 2 homolog0022
Actin-related protein 30022
Actin-related protein 20011
Calcium-dependent protein kinase 10022
GTP-binding nuclear protein Ran0022
Casein kinase II subunit alpha0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0022
SRSF protein kinase 20022
Casein kinase I isoform gamma-20022
Mitogen-activated protein kinase kinase kinase 90022
Serine/threonine-protein kinase PknB0022
Cyclin-dependent kinase 30022
Cyclin-dependent kinase-like 10022
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0123
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Protein kinase C epsilon type0022
Dual specificity mitogen-activated protein kinase kinase 10022
Mitogen-activated protein kinase kinase kinase 100022
DNA topoisomerase 2-beta0022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0123
Tyrosine-protein kinase receptor TYRO30022
Cyclin-dependent kinase 180022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Tyrosine-protein kinase ITK/TSK0123
Myotonin-protein kinase0022
Mitogen-activated protein kinase kinase kinase kinase 20022
Mitogen-activated protein kinase kinase kinase 120022
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Serine/threonine-protein kinase PAK 10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
cGMP-dependent protein kinase 20022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Serine/threonine-protein kinase PRP4 homolog0022
Receptor-interacting serine/threonine-protein kinase 10022
Calcium/calmodulin-dependent protein kinase type II subunit beta0022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Calcium/calmodulin-dependent protein kinase type 10022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10011
Serine/threonine-protein kinase D10022
Serine/threonine-protein kinase 380022
Receptor tyrosine-protein kinase erbB-40123
Ribosomal protein S6 kinase alpha-20022
Ephrin type-A receptor 70022
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110123
Serine/threonine-protein kinase STK110022
Rhodopsin kinase GRK10022
NT-3 growth factor receptor0022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140224
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
BDNF/NT-3 growth factors receptor0022
Mitogen-activated protein kinase 60022
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0022
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10123
Myosin light chain kinase 30022
Serine/threonine-protein kinase SBK10022
Mitogen-activated protein kinase kinase kinase 190022
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase TNNI3K0022
Leucine-rich repeat serine/threonine-protein kinase 20022
Serine/threonine-protein kinase MRCK alpha0022
Tyrosine-protein kinase JAK2 0011
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase Nek50022
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30022
Dual serine/threonine and tyrosine protein kinase0022
Mitogen-activated protein kinase kinase kinase 150022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
Serine/threonine-protein kinase tousled-like 20022
Serine/threonine-protein kinase 32C0022
Serine/threonine-protein kinase pim-30022
Serine/threonine-protein kinase VRK20022
Myosin light chain kinase family member 40022
Homeodomain-interacting protein kinase 10022
Calcium/calmodulin-dependent protein kinase type 1D0022
Mitogen-activated protein kinase kinase kinase kinase 30022
Cyclin-dependent kinase-like 30022
MAP kinase-activated protein kinase 50123
Serine/threonine-protein kinase BRSK20022
Serine/threonine-protein kinase NIM10022
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Serine/threonine-protein kinase ULK20022
Misshapen-like kinase 10022
Serine/threonine-protein kinase DCLK20022
Calcium/calmodulin-dependent protein kinase kinase 10022
Casein kinase I isoform alpha-like0022
Homeodomain-interacting protein kinase 40022
Myosin-IIIa0022
Ankyrin repeat and protein kinase domain-containing protein 10022
Serine/threonine-protein kinase Nek110022
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase BRSK10022
Serine/threonine-protein kinase 350022
Serine/threonine-protein kinase Nek70022
Rhodopsin kinase GRK70022
Serine/threonine-protein kinase 32A0022
Myosin-IIIb0022
ATP-dependent RNA helicase DDX10022
Dual specificity tyrosine-phosphorylation-regulated kinase 20022
Cyclin-dependent kinase-like 20022
Mitogen-activated protein kinase kinase kinase kinase 10022
Serine/threonine-protein kinase Sgk30022
Atypical kinase COQ8B, mitochondrial0022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Calcium/calmodulin-dependent protein kinase type 1G0022
Serine/threonine-protein kinase Nek10022
Cyclin-dependent kinase 150022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
SRSF protein kinase 10022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Serine/threonine-protein kinase RIO10022
MAP kinase-interacting serine/threonine-protein kinase 10022
Serine/threonine-protein kinase RIO20022
Cyclin-dependent kinase 190022
Transient receptor potential cation channel subfamily M member 60022
Testis-specific serine/threonine-protein kinase 10022
Serine/threonine-protein kinase 330022
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
Serine/threonine-protein kinase DCLK30022
NUAK family SNF1-like kinase 20022
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
Myosin light chain kinase 2, skeletal/cardiac muscle0022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
Homeodomain-interacting protein kinase 20022
Tyrosine-protein kinase Srms0022
Homeodomain-interacting protein kinase 30022
Serine/threonine-protein kinase PLK30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
MAP kinase-interacting serine/threonine-protein kinase 20022
Serine/threonine-protein kinase Nek60022
Casein kinase I isoform gamma-10022
Serine/threonine-protein kinase PAK 60022
SNF-related serine/threonine-protein kinase0022
Serine/threonine-protein kinase LATS20022
Serine/threonine-protein kinase 360022
Phenylalanine--tRNA ligase beta subunit0022
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Serine/threonine-protein kinase 32B0022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
Serine/threonine-protein kinase PLK20022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase MARK10022
Serine/threonine-protein kinase pim-20022
Serine/threonine-protein kinase PAK 50022
Serine/threonine-protein kinase 260022
eIF-2-alpha kinase GCN20022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
Phosphatidylinositol 4-kinase beta0022
Histone deacetylase 60101
Serine/threonine-protein kinase 17A0022
STE20/SPS1-related proline-alanine-rich protein kinase0022
Ephrin type-A receptor 60022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10123
Septin-90022
Death-associated protein kinase 20022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase tousled-like 10022
Serine/threonine-protein kinase TAO20022
ALK tyrosine kinase receptor0022
SRSF protein kinase 30022
Serine/threonine-protein kinase ICK0022
Cyclin-dependent kinase 11A0022
Aurora kinase C0022
Calcium/calmodulin-dependent protein kinase type II subunit alpha0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase 38-like0022
Microtubule-associated serine/threonine-protein kinase 10022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Serine/threonine-protein kinase 240022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
5-hydroxytryptamine receptor 40606
Glucose-6-phosphate 1-dehydrogenase0101
5-hydroxytryptamine receptor 1A0505
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40103
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0606
5-hydroxytryptamine receptor 1B0404
D(3) dopamine receptor0808
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B0808
5-hydroxytryptamine receptor 60202
6-phosphogluconate dehydrogenase, decarboxylating0101
alpha-galactosidase1001
NPC intracellular cholesterol transporter 1 precursor2002
phosphoethanolamine/phosphocholine phosphatase isoform 10101
M-phase phosphoprotein 81001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10404
Sodium/potassium-transporting ATPase subunit alpha-1 0303
Sodium/potassium-transporting ATPase subunit beta-10303
Microtubule-associated protein tau0101
Sodium/potassium-transporting ATPase subunit alpha-30303
Sodium/potassium-transporting ATPase subunit beta-20303
Indoleamine 2,3-dioxygenase 10202
Fatty acid synthase0808
Sodium/potassium-transporting ATPase subunit alpha-20303
Sodium/potassium-transporting ATPase subunit beta-30303
Sodium/potassium-transporting ATPase subunit gamma0303
Sodium/potassium-transporting ATPase subunit alpha-40303
Indoleamine 2,3-dioxygenase 20202
matrix metalloproteinase 1, partial0011
Thrombopoietin4004
nonstructural protein 13003
P531001
histone deacetylase 9 isoform 33003
neuropeptide S receptor isoform A1001
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Aldo-keto reductase family 1 member B10606
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent dopamine transporter 0404
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Protein-arginine deiminase type-40101
Leukotriene A-4 hydrolase0001
Cysteinyl leukotriene receptor 20112
Cysteinyl leukotriene receptor 10224
beta-2 adrenergic receptor2013
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor011319
Glycine receptor subunit alpha-1010010
Androgen receptor0505
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
Nuclear receptor subfamily 1 group I member 20011
isocitrate dehydrogenase 1, partial1001
Progesterone receptor0315
Substance-K receptor0202
Delta-type opioid receptor0202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Leukotriene C4 synthase0101
Cysteinyl leukotriene receptor 10101
ClpP1001
pyruvate kinase PKM isoform a1001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
UDP-glucuronosyltransferase 2B70102
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
Potassium-transporting ATPase alpha chain 10101
Bombesin receptor subtype-30011
UDP-glucuronosyltransferase 2B10 0101
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 20001
Glutathione S-transferase omega-10101
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0112
Glutamate receptor ionotropic, NMDA 3B0112
Muscarinic acetylcholine receptor M10033
Muscarinic acetylcholine receptor M30033
Muscarinic acetylcholine receptor M40033
Muscarinic acetylcholine receptor M50033
Muscarinic acetylcholine receptor M20033
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Sodium-dependent serotonin transporter0202
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0102
Kappa-type opioid receptor0001
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10213
Glutamate receptor ionotropic, NMDA 2A0213
Glutamate receptor ionotropic, NMDA 2B0224
Glutamate receptor ionotropic, NMDA 2C0112
Glutamate receptor ionotropic, NMDA 3A0112
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
CDGSH iron-sulfur domain-containing protein 10202
Free fatty acid receptor 10022
Peroxisome proliferator-activated receptor gamma0101
Tyrosine-protein phosphatase non-receptor type 10202
Carnitine O-palmitoyltransferase 2, mitochondrial0202
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] A 0202
Peroxisome proliferator-activated receptor alpha0213
Carnitine O-palmitoyltransferase 2, mitochondrial0202
Peroxisome proliferator-activated receptor gamma04410
Peroxisome proliferator-activated receptor gamma0123
Carnitine O-palmitoyltransferase 1, liver isoform0202
Peroxisome proliferator-activated receptor alpha0325
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
CDGSH iron-sulfur domain-containing protein 20202
CDGSH iron-sulfur domain-containing protein 10404
C-X-C chemokine receptor type 40101
Atypical chemokine receptor 30011
C-C chemokine receptor type 20202
C-X-C chemokine receptor type 40204
luciferase0001
Estrogen receptor0303
Glucocorticoid receptor0213
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0325
Androgen receptor0202
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0303
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A80001
Solute carrier organic anion transporter family member 2A10101
Interleukin-50101
Interleukin-50101
Interleukin-5 receptor subunit alpha0101
Insulin-degrading enzyme0101
menin isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Thromboxane A2 receptor 0202
Prostaglandin D2 receptor0202
Acyl-CoA:cholesterol acyltransferase 0101
Neuronal acetylcholine receptor subunit alpha-60101
Prostaglandin D2 receptor 20202
Sphingosine kinase 20202
Sphingosine kinase 10101
Cytochrome P450 3A50112
Catechol O-methyltransferase0011
Cannabinoid receptor 20011
Mu-type opioid receptor0101
Peroxisome proliferator-activated receptor delta0213
ATP-binding cassette sub-family C member 80101
ATP-sensitive inward rectifier potassium channel 110101
Sodium/bile acid cotransporter0101
Thrombin 0011
LMP1 [Human herpesvirus 4]0001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
galanin receptor type 30101
D(1A) dopamine receptor1001
dopamine D1 receptor1001
DNA topoisomerase 2-alpha0112
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
Caspase-20011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Adenylate kinase isoenzyme 10001
Capsid protein 0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80001
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Serine/threonine-protein kinase Sgk10101
Membrane-associated progesterone receptor component 10011
Signal recognition particle receptor subunit alpha0011
Myosin light chain kinase, smooth muscle0011
Ras-related protein Rab-6A0011
Tubulin alpha-1A chain0011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Uncharacterized aarF domain-containing protein kinase 50011
Rab-like protein 30011
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
ATP-dependent RNA helicase DHX300011
Dual specificity testis-specific protein kinase 20011
Long-chain-fatty-acid--CoA ligase 50011
HLA class I histocompatibility antigen, A alpha chain 0011
procathepsin L isoform 1 preproprotein0101
Taste receptor type 2 member 310011
Taste receptor type 2 member 10011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10102
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Chloroquine resistance transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]